SLC4A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemoglobin metabolic process (GO:0020027)9.60844580
2response to methylmercury (GO:0051597)9.02193521
3erythrocyte development (GO:0048821)8.14893712
4tetrapyrrole metabolic process (GO:0033013)7.42781603
5branching involved in labyrinthine layer morphogenesis (GO:0060670)7.35944471
6response to insecticide (GO:0017085)7.28347371
7response to lead ion (GO:0010288)7.08368961
8pigment biosynthetic process (GO:0046148)6.11768919
9erythrocyte differentiation (GO:0030218)5.89696262
10myeloid cell development (GO:0061515)5.63165484
11regulation of response to osmotic stress (GO:0047484)5.32728528
12spindle assembly involved in mitosis (GO:0090307)5.09514146
13pigment metabolic process (GO:0042440)5.06363595
14very-low-density lipoprotein particle assembly (GO:0034379)5.01889993
15response to arsenic-containing substance (GO:0046685)4.91432734
16negative regulation of erythrocyte differentiation (GO:0045647)4.81550987
17glycine transport (GO:0015816)4.64135170
18positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.47733577
19one-carbon compound transport (GO:0019755)4.42579655
20actin filament capping (GO:0051693)4.42322340
21iron ion import (GO:0097286)4.35154001
22mitotic sister chromatid segregation (GO:0000070)4.30329565
23regulation of syncytium formation by plasma membrane fusion (GO:0060142)4.29238320
24plasma lipoprotein particle assembly (GO:0034377)4.22696448
25mitochondrion degradation (GO:0000422)4.21974501
26regulation of cytokine secretion involved in immune response (GO:0002739)4.16664574
27regulation of inositol phosphate biosynthetic process (GO:0010919)4.14462164
28DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.13269642
29centrosome duplication (GO:0051298)4.12149146
30mitochondrion morphogenesis (GO:0070584)4.08820004
31positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.08635199
32microtubule cytoskeleton organization involved in mitosis (GO:1902850)4.05690135
33platelet formation (GO:0030220)4.01039698
34sister chromatid segregation (GO:0000819)4.00512862
35negative regulation of viral entry into host cell (GO:0046597)3.98878545
36L-alpha-amino acid transmembrane transport (GO:1902475)3.95990025
37calcium-mediated signaling using intracellular calcium source (GO:0035584)3.94337255
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.88576382
39embryonic hemopoiesis (GO:0035162)3.86896644
40protein-lipid complex assembly (GO:0065005)3.72202677
41cellular response to arsenic-containing substance (GO:0071243)3.71219362
42regulation of translational termination (GO:0006449)3.68401516
43DNA damage response, signal transduction resulting in transcription (GO:0042772)3.67242475
44negative regulation of Rho protein signal transduction (GO:0035024)3.65654214
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.62351160
46N-terminal protein amino acid acetylation (GO:0006474)3.61241128
47chromatin assembly (GO:0031497)3.59906386
48water-soluble vitamin biosynthetic process (GO:0042364)3.58750232
49CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.56547345
50regulation of DNA endoreduplication (GO:0032875)3.55170368
51cell differentiation involved in embryonic placenta development (GO:0060706)3.54866663
52cofactor biosynthetic process (GO:0051188)3.53010522
53negative regulation of actin filament depolymerization (GO:0030835)3.51663846
54positive regulation of granulocyte differentiation (GO:0030854)3.49927349
55inner cell mass cell proliferation (GO:0001833)3.48928336
56granulocyte differentiation (GO:0030851)3.44811019
57megakaryocyte development (GO:0035855)3.44022726
58microtubule depolymerization (GO:0007019)3.42111420
59mitotic chromosome condensation (GO:0007076)3.42051938
60gas transport (GO:0015669)3.38795109
61mitochondrial fusion (GO:0008053)3.38669217
62preassembly of GPI anchor in ER membrane (GO:0016254)3.34673374
63regulation of cell proliferation involved in kidney development (GO:1901722)3.34034698
64nucleosome assembly (GO:0006334)3.32887067
65heme transport (GO:0015886)3.32454154
66protein localization to chromosome, centromeric region (GO:0071459)3.29020996
67positive regulation of erythrocyte differentiation (GO:0045648)3.26728948
68positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24249727
69positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24249727
70positive regulation of mitotic sister chromatid separation (GO:1901970)3.24249727
71regulation of tight junction assembly (GO:2000810)3.23936968
72regulation of sequestering of triglyceride (GO:0010889)3.22773754
73positive regulation of chromosome segregation (GO:0051984)3.20549349
74cellular response to virus (GO:0098586)3.15135911
75regulation of energy homeostasis (GO:2000505)3.13891677
763-UTR-mediated mRNA stabilization (GO:0070935)3.12556786
77import into cell (GO:0098657)3.12152992
78anterior/posterior axis specification, embryo (GO:0008595)3.04208006
79positive regulation of megakaryocyte differentiation (GO:0045654)3.02850152
80iron ion homeostasis (GO:0055072)3.02309960
81gland morphogenesis (GO:0022612)3.01848966
82protoporphyrinogen IX metabolic process (GO:0046501)22.0681000
83protoporphyrinogen IX biosynthetic process (GO:0006782)20.2426676
84DNA replication-dependent nucleosome organization (GO:0034723)2.99845108
85DNA replication-dependent nucleosome assembly (GO:0006335)2.99845108
86regulation of erythrocyte differentiation (GO:0045646)2.99168780
87prostate gland growth (GO:0060736)2.98970188
88nucleosome organization (GO:0034728)2.98469547
89regulation of viral entry into host cell (GO:0046596)2.97733423
90mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.97729904
91protein localization to kinetochore (GO:0034501)2.96576319
92defense response to fungus (GO:0050832)2.95483162
93ovulation from ovarian follicle (GO:0001542)2.94486949
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.93968507
95antibacterial humoral response (GO:0019731)2.93586276
96disruption of cells of other organism (GO:0044364)2.93310664
97killing of cells of other organism (GO:0031640)2.93310664
98monoubiquitinated protein deubiquitination (GO:0035520)2.92274312
99definitive hemopoiesis (GO:0060216)2.92219461
100T cell lineage commitment (GO:0002360)2.91264591
101cellular response to dexamethasone stimulus (GO:0071549)2.87874537
102regulation of platelet aggregation (GO:0090330)2.85731494
103positive regulation of mitochondrial fission (GO:0090141)2.84629307
104DNA unwinding involved in DNA replication (GO:0006268)2.84182071
105negative regulation of actin filament polymerization (GO:0030837)2.84095016
106DNA replication initiation (GO:0006270)2.79870532
107mucosal immune response (GO:0002385)2.77654123
108regulation of exit from mitosis (GO:0007096)2.77505064
109TOR signaling (GO:0031929)2.77438386
110regulation of glial cell proliferation (GO:0060251)2.75656577
111protein-DNA complex assembly (GO:0065004)2.75636972
112negative regulation of telomerase activity (GO:0051974)2.74775205
113response to dexamethasone (GO:0071548)2.72397967
114protein insertion into membrane (GO:0051205)2.71332839
115positive regulation of fibroblast migration (GO:0010763)2.71190105
116positive regulation of fatty acid oxidation (GO:0046321)2.71105926
117antimicrobial humoral response (GO:0019730)2.70596140
118DNA replication checkpoint (GO:0000076)2.69381337
119positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.69231458
120regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.68081637
121kinetochore organization (GO:0051383)2.65025741
122lipopolysaccharide biosynthetic process (GO:0009103)2.63352684
123organ or tissue specific immune response (GO:0002251)2.60880284
124positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.60656748
125DNA deamination (GO:0045006)2.60334327
126attachment of spindle microtubules to kinetochore (GO:0008608)2.60083829
127innate immune response in mucosa (GO:0002227)2.60044874
128negative regulation of smooth muscle cell differentiation (GO:0051151)2.59860914
129regulation of histone H3-K9 methylation (GO:0051570)2.58596245
130chromatin assembly or disassembly (GO:0006333)2.58024447
131positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.57636971
132protein-DNA complex subunit organization (GO:0071824)2.56179637
133regulation of actin filament depolymerization (GO:0030834)2.53916807
134plasma lipoprotein particle organization (GO:0071827)2.52229269
135meiotic chromosome segregation (GO:0045132)2.50581349
136hemopoiesis (GO:0030097)2.48959625
137response to iron ion (GO:0010039)2.45056456
138protein autoprocessing (GO:0016540)2.41060781
139protein-cofactor linkage (GO:0018065)2.36556568
140regulation of centriole replication (GO:0046599)2.35924558
141protein-lipid complex subunit organization (GO:0071825)2.33908188
142receptor recycling (GO:0001881)2.30139446
143hepatocyte apoptotic process (GO:0097284)2.26982781
144transition metal ion homeostasis (GO:0055076)2.26110202
145lipopolysaccharide metabolic process (GO:0008653)2.24049043
146DNA strand elongation involved in DNA replication (GO:0006271)2.20733008
147positive regulation of Rho protein signal transduction (GO:0035025)2.20650415
148negative regulation of protein polymerization (GO:0032272)2.20541236
149porphyrin-containing compound biosynthetic process (GO:0006779)14.6243506
150heme biosynthetic process (GO:0006783)13.4814610
151tetrapyrrole biosynthetic process (GO:0033014)13.0470922
152porphyrin-containing compound metabolic process (GO:0006778)11.5582649
153oxygen transport (GO:0015671)10.8601641
154erythrocyte maturation (GO:0043249)10.7401527
155heme metabolic process (GO:0042168)10.5493400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.48275950
2STAT6_21828071_ChIP-Seq_BEAS2B_Human6.39740517
3FOXM1_23109430_ChIP-Seq_U2OS_Human6.14902944
4GATA1_22025678_ChIP-Seq_K562_Human5.99516340
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.76894708
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.38022743
7* GATA1_19941826_ChIP-Seq_K562_Human4.96673839
8* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse4.34829755
9* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse4.07183498
10* GATA1_19941827_ChIP-Seq_MEL_Mouse3.82827346
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45549383
12SCL_19346495_ChIP-Seq_HPC-7_Human3.35989973
13* GATA2_19941826_ChIP-Seq_K562_Human2.78085535
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72481845
15GATA1_22383799_ChIP-Seq_G1ME_Mouse2.66318678
16MYC_22102868_ChIP-Seq_BL_Human2.04916854
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83744184
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83394804
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.79674234
20ZNF263_19887448_ChIP-Seq_K562_Human1.79556657
21VDR_21846776_ChIP-Seq_THP-1_Human1.72619222
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70898778
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65165176
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60604846
25* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58469078
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50916702
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49550085
28AR_21909140_ChIP-Seq_LNCAP_Human1.45704618
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41571770
30* NCOR1_26117541_ChIP-Seq_K562_Human1.40674112
31GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37918592
32SOX2_16153702_ChIP-ChIP_HESCs_Human1.34683090
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34614991
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33980988
35* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30862282
36* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26803019
37FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26211344
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24692765
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22875166
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21077413
41MAF_26560356_Chip-Seq_TH1_Human1.20914823
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19818588
43MYB_26560356_Chip-Seq_TH1_Human1.19311020
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19077859
45CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17501474
46KDM2B_26808549_Chip-Seq_DND41_Human1.16157649
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15201862
48TCF7_22412390_ChIP-Seq_EML_Mouse1.12647356
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12357305
50TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12006752
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11758416
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11356975
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11183984
54BCOR_27268052_Chip-Seq_Bcells_Human1.10589391
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.10513733
56UTX_26944678_Chip-Seq_JUKART_Human1.08856068
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07211782
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07075033
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06010755
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05806488
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03357847
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.02908009
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02254484
64GATA3_27048872_Chip-Seq_THYMUS_Human1.01805457
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01791263
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.01270036
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00602483
68CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00567434
69PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99921263
70MYB_26560356_Chip-Seq_TH2_Human0.99415894
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98441762
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97981622
73SRF_21415370_ChIP-Seq_HL-1_Mouse0.96104069
74BCL6_27268052_Chip-Seq_Bcells_Human0.95767099
75* RUNX1_22412390_ChIP-Seq_EML_Mouse0.95469491
76ELK3_25401928_ChIP-Seq_HUVEC_Human0.93862293
77YY1_22570637_ChIP-Seq_MALME-3M_Human0.92271096
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91744081
79* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91351942
80RXR_22158963_ChIP-Seq_LIVER_Mouse0.91348136
81MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91127472
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89436742
83RUNX_20019798_ChIP-Seq_JUKART_Human0.88778027
84IRF1_19129219_ChIP-ChIP_H3396_Human0.88648452
85KDM5A_27292631_Chip-Seq_BREAST_Human0.88604158
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88577310
87VDR_24763502_ChIP-Seq_THP-1_Human0.87904509
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87115687
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86237370
90IRF8_22096565_ChIP-ChIP_GC-B_Human0.85771875
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85178539
92ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85059714
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83853610
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.82118456
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81748409
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81580867
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81368923
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81319333
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80608797
100FOXP3_21729870_ChIP-Seq_TREG_Human0.79913338
101MYC_19030024_ChIP-ChIP_MESCs_Mouse0.79747483
102TFEB_21752829_ChIP-Seq_HELA_Human0.79650056
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77160452
104VDR_23849224_ChIP-Seq_CD4+_Human0.77012609
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76943592
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76666933
107* KDM2B_26808549_Chip-Seq_K562_Human0.76374246
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76032444
109MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75354559
110STAT4_19710469_ChIP-ChIP_TH1__Mouse0.75214158
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74578327
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74467902
113MAF_26560356_Chip-Seq_TH2_Human0.74290038
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.73633769
115NANOG_20526341_ChIP-Seq_ESCs_Human0.73590477
116SPI1_23127762_ChIP-Seq_K562_Human0.73571805
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73360736
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.73310624
119* IRF8_27001747_Chip-Seq_BMDM_Mouse0.71607330
120CIITA_25753668_ChIP-Seq_RAJI_Human0.71570200
121SPI1_23547873_ChIP-Seq_NB4_Human0.71569000
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.70387371
123GATA6_25053715_ChIP-Seq_YYC3_Human0.70312502
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.70228294
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.70188907
126* SA1_27219007_Chip-Seq_ERYTHROID_Human0.69661271
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68934727
128MYC_18358816_ChIP-ChIP_MESCs_Mouse0.67900276
129P68_20966046_ChIP-Seq_HELA_Human0.66769265
130CREB1_15753290_ChIP-ChIP_HEK293T_Human0.65720543
131XRN2_22483619_ChIP-Seq_HELA_Human0.65481118
132CTCF_21964334_Chip-Seq_Bcells_Human0.65106198
133MYC_18555785_ChIP-Seq_MESCs_Mouse0.65011443
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.64961573
135LXR_22292898_ChIP-Seq_THP-1_Human0.64776377
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.63480312
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.62931913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology9.52344746
2MP0005083_abnormal_biliary_tract4.44380699
3* MP0003111_abnormal_nucleus_morphology2.80299692
4MP0001545_abnormal_hematopoietic_system2.39662331
5MP0005397_hematopoietic_system_phenotyp2.39662331
6MP0010094_abnormal_chromosome_stability2.38290659
7MP0003315_abnormal_perineum_morphology2.31812964
8MP0003077_abnormal_cell_cycle2.12644137
9MP0004147_increased_porphyrin_level11.6605711
10* MP0003656_abnormal_erythrocyte_physiolo11.5008815
11* MP0005636_abnormal_mineral_homeostasis1.89584673
12MP0010307_abnormal_tumor_latency1.89266953
13MP0005367_renal/urinary_system_phenotyp1.86191984
14MP0000516_abnormal_urinary_system1.86191984
15MP0003724_increased_susceptibility_to1.85881544
16MP0005670_abnormal_white_adipose1.83280918
17MP0004130_abnormal_muscle_cell1.67495772
18MP0005464_abnormal_platelet_physiology1.63894444
19MP0001849_ear_inflammation1.60341986
20MP0003172_abnormal_lysosome_physiology1.57438399
21MP0003693_abnormal_embryo_hatching1.53098700
22MP0000685_abnormal_immune_system1.52572345
23MP0008775_abnormal_heart_ventricle1.49743546
24MP0000013_abnormal_adipose_tissue1.46319141
25* MP0002398_abnormal_bone_marrow1.40506816
26MP0008057_abnormal_DNA_replication1.35572897
27MP0005501_abnormal_skin_physiology1.29692385
28MP0001915_intracranial_hemorrhage1.29314631
29MP0001485_abnormal_pinna_reflex1.24702325
30MP0001188_hyperpigmentation1.22644899
31MP0002396_abnormal_hematopoietic_system1.21661403
32MP0000350_abnormal_cell_proliferation1.20916200
33* MP0002722_abnormal_immune_system1.19857038
34MP0005174_abnormal_tail_pigmentation1.18627802
35* MP0000689_abnormal_spleen_morphology1.18350093
36MP0004957_abnormal_blastocyst_morpholog1.18137371
37MP0002139_abnormal_hepatobiliary_system1.16194750
38MP0000490_abnormal_crypts_of1.14896668
39* MP0009765_abnormal_xenobiotic_induced1.13537186
40MP0000015_abnormal_ear_pigmentation1.13437681
41MP0005076_abnormal_cell_differentiation1.09697363
42MP0008260_abnormal_autophagy1.07095040
43MP0006036_abnormal_mitochondrial_physio1.06370509
44* MP0002429_abnormal_blood_cell1.05796657
45* MP0009931_abnormal_skin_appearance1.03375101
46MP0005377_hearing/vestibular/ear_phenot0.99487337
47MP0003878_abnormal_ear_physiology0.99487337
48MP0000313_abnormal_cell_death0.98791177
49MP0003300_gastrointestinal_ulcer0.97786473
50MP0009333_abnormal_splenocyte_physiolog0.97718629
51MP0000609_abnormal_liver_physiology0.96224608
52MP0004808_abnormal_hematopoietic_stem0.94451995
53MP0003186_abnormal_redox_activity0.94206023
54MP0002019_abnormal_tumor_incidence0.92725701
55MP0002877_abnormal_melanocyte_morpholog0.91099041
56MP0005075_abnormal_melanosome_morpholog0.90836289
57MP0003705_abnormal_hypodermis_morpholog0.89582725
58MP0008995_early_reproductive_senescence0.88970528
59MP0009379_abnormal_foot_pigmentation0.88960141
60MP0003303_peritoneal_inflammation0.86579434
61MP0002086_abnormal_extraembryonic_tissu0.84656816
62MP0001730_embryonic_growth_arrest0.83498769
63MP0008058_abnormal_DNA_repair0.82464907
64MP0000703_abnormal_thymus_morphology0.81154623
65MP0008873_increased_physiological_sensi0.79503722
66MP0002080_prenatal_lethality0.78685743
67* MP0008770_decreased_survivor_rate0.78520977
68MP0005360_urolithiasis0.77980385
69MP0009764_decreased_sensitivity_to0.77227263
70MP0004885_abnormal_endolymph0.76967857
71MP0003123_paternal_imprinting0.76073615
72MP0003191_abnormal_cellular_cholesterol0.75902289
73MP0003045_fibrosis0.75609731
74MP0001661_extended_life_span0.75468413
75MP0009278_abnormal_bone_marrow0.74911319
76MP0000598_abnormal_liver_morphology0.74064920
77MP0003786_premature_aging0.73930888
78MP0003890_abnormal_embryonic-extraembry0.73474082
79MP0005621_abnormal_cell_physiology0.71328992
80MP0001529_abnormal_vocalization0.71247431
81MP0005671_abnormal_response_to0.70012413
82MP0001697_abnormal_embryo_size0.68543845
83MP0004185_abnormal_adipocyte_glucose0.67699530
84MP0004197_abnormal_fetal_growth/weight/0.67686491
85MP0002009_preneoplasia0.66997834
86MP0002160_abnormal_reproductive_system0.66753740
87MP0002132_abnormal_respiratory_system0.66748505
88MP0005025_abnormal_response_to0.66561792
89MP0000049_abnormal_middle_ear0.65728085
90MP0008877_abnormal_DNA_methylation0.65090742
91MP0002405_respiratory_system_inflammati0.64538284
92MP0000003_abnormal_adipose_tissue0.64374872
93MP0003787_abnormal_imprinting0.64211805
94MP0009672_abnormal_birth_weight0.63265096
95MP0010771_integument_phenotype0.62602211
96MP0005384_cellular_phenotype0.62256470
97MP0000749_muscle_degeneration0.62204247
98MP0009053_abnormal_anal_canal0.61714438
99MP0005085_abnormal_gallbladder_physiolo0.60292313
100MP0001270_distended_abdomen0.60015039
101MP0005380_embryogenesis_phenotype0.59902544
102MP0001672_abnormal_embryogenesis/_devel0.59902544
103MP0010352_gastrointestinal_tract_polyps0.58380755
104MP0003119_abnormal_digestive_system0.57647016
105MP0003984_embryonic_growth_retardation0.57197000
106MP0002088_abnormal_embryonic_growth/wei0.55089702
107MP0002419_abnormal_innate_immunity0.54811542
108MP0000716_abnormal_immune_system0.54668300
109MP0002420_abnormal_adaptive_immunity0.54068854
110MP0003121_genomic_imprinting0.52995196
111MP0006054_spinal_hemorrhage0.52422051
112MP0001819_abnormal_immune_cell0.52156381
113MP0005000_abnormal_immune_tolerance0.51783011
114MP0003566_abnormal_cell_adhesion0.51536201
115MP0001835_abnormal_antigen_presentation0.51325539
116MP0010329_abnormal_lipoprotein_level0.51230728
117MP0001800_abnormal_humoral_immune0.50773489
118MP0004264_abnormal_extraembryonic_tissu0.49322112
119MP0002138_abnormal_hepatobiliary_system0.49254705
120MP0009703_decreased_birth_body0.48759698
121MP0002095_abnormal_skin_pigmentation0.48140670
122MP0003806_abnormal_nucleotide_metabolis0.46905840
123* MP0002135_abnormal_kidney_morphology0.46130391
124MP0001191_abnormal_skin_condition0.45164088
125MP0000465_gastrointestinal_hemorrhage0.44932459
126MP0005387_immune_system_phenotype0.44718776
127MP0001790_abnormal_immune_system0.44718776
128MP0009785_altered_susceptibility_to0.44344355
129MP0000858_altered_metastatic_potential0.43142566
130MP0000537_abnormal_urethra_morphology0.42981461
131MP0002277_abnormal_respiratory_mucosa0.42925514
132MP0008932_abnormal_embryonic_tissue0.42657978
133* MP0009763_increased_sensitivity_to0.42016884
134MP0005220_abnormal_exocrine_pancreas0.41827066
135MP0002970_abnormal_white_adipose0.41744892
136MP0005310_abnormal_salivary_gland0.41225203
137MP0008789_abnormal_olfactory_epithelium0.41041423
138* MP0000266_abnormal_heart_morphology0.40655277
139MP0008007_abnormal_cellular_replicative0.38643687
140MP0002736_abnormal_nociception_after0.38431014
141MP0002166_altered_tumor_susceptibility0.37789470
142MP0005319_abnormal_enzyme/_coenzyme0.36484338
143MP0002083_premature_death0.35346883
144MP0005499_abnormal_olfactory_system0.35120019
145MP0005394_taste/olfaction_phenotype0.35120019

Predicted human phenotypes

RankGene SetZ-score
1Cholelithiasis (HP:0001081)8.11827008
2* Reticulocytosis (HP:0001923)7.39269659
3Abnormal gallbladder morphology (HP:0012437)7.35291036
4Diaphragmatic weakness (HP:0009113)7.22130975
5Insomnia (HP:0100785)5.92065989
6Short 1st metacarpal (HP:0010034)5.71619574
7Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.71619574
8Hypochromic anemia (HP:0001931)5.69180662
9Abnormal hemoglobin (HP:0011902)5.50743666
10* Hyperbilirubinemia (HP:0002904)5.10715584
11Abnormality of the gallbladder (HP:0005264)5.08801798
12Microcytic anemia (HP:0001935)5.03014662
13Abnormality of the 1st metacarpal (HP:0010009)5.01525037
14Toxemia of pregnancy (HP:0100603)4.92863848
15* Acanthocytosis (HP:0001927)4.86426396
16* Abnormality of reticulocytes (HP:0004312)4.82917012
17Cutaneous photosensitivity (HP:0000992)4.70801355
18Abnormal gallbladder physiology (HP:0012438)4.62799784
19Cholecystitis (HP:0001082)4.62799784
20Ileus (HP:0002595)4.14929779
21Ectopic kidney (HP:0000086)4.09414105
22Carpal bone hypoplasia (HP:0001498)4.08541334
23Polycythemia (HP:0001901)4.05825515
24Duplicated collecting system (HP:0000081)3.90018370
25Stenosis of the external auditory canal (HP:0000402)3.77150881
26Abnormality of the renal collecting system (HP:0004742)3.74055652
27* Paralysis (HP:0003470)3.69546317
28Short phalanx of the thumb (HP:0009660)3.62328291
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.53697642
30Abnormal number of erythroid precursors (HP:0012131)3.52926789
31Hepatocellular carcinoma (HP:0001402)3.41855879
32Absent thumb (HP:0009777)3.34997887
33Rectal fistula (HP:0100590)3.30833376
34Rectovaginal fistula (HP:0000143)3.30833376
35Chromsome breakage (HP:0040012)3.25768849
36Hyponatremia (HP:0002902)3.25606874
37Abnormality of cells of the erythroid lineage (HP:0012130)3.22158924
38Intestinal fistula (HP:0100819)3.18522800
39Increased serum ferritin (HP:0003281)3.07867689
40Abnormality of sodium homeostasis (HP:0010931)3.02145298
41Pustule (HP:0200039)3.01652687
42Abnormality of iron homeostasis (HP:0011031)2.97051178
43Confusion (HP:0001289)2.88184790
44Petechiae (HP:0000967)2.87506359
45Urticaria (HP:0001025)2.84758937
46Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.82792625
47Generalized hyperpigmentation (HP:0007440)2.80834971
48Global brain atrophy (HP:0002283)2.78895537
49Abnormality of DNA repair (HP:0003254)2.75976432
50Vaginal fistula (HP:0004320)2.74426884
51Birth length less than 3rd percentile (HP:0003561)2.72450834
52Abnormality of the parathyroid morphology (HP:0011766)2.71950006
53Abnormality of transition element cation homeostasis (HP:0011030)2.69162670
54Rectal prolapse (HP:0002035)2.60269499
55Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.60187381
56Reticulocytopenia (HP:0001896)2.51700267
57Prolonged bleeding time (HP:0003010)2.49499564
58Fused cervical vertebrae (HP:0002949)2.39141010
59Nausea (HP:0002018)2.37537888
60Onycholysis (HP:0001806)2.34847965
61Short hallux (HP:0010109)2.30748738
62Cerebral palsy (HP:0100021)2.23667434
63Gastrointestinal infarctions (HP:0005244)2.21409187
64Short thumb (HP:0009778)2.18557476
65Horseshoe kidney (HP:0000085)2.12892770
66Nonimmune hydrops fetalis (HP:0001790)2.12033512
67Leukocytosis (HP:0001974)2.11460832
68Delusions (HP:0000746)2.09710129
69Aplasia/Hypoplasia of the hallux (HP:0008362)2.08779209
70Short humerus (HP:0005792)2.06989334
71Lower limb hyperreflexia (HP:0002395)2.03124231
72Ureteral duplication (HP:0000073)2.01190703
73Hypertensive crisis (HP:0100735)2.00203512
74Epistaxis (HP:0000421)2.00142252
75Abnormality of the heme biosynthetic pathway (HP:0010472)15.6241091
76* Poikilocytosis (HP:0004447)14.0991392
77Hypochromic microcytic anemia (HP:0004840)11.3384712
78Abnormality of the fingertips (HP:0001211)1.99753002
79Aplasia/Hypoplasia involving the musculature (HP:0001460)1.98120030
80Absent radius (HP:0003974)1.97313602
81Short middle phalanx of the 5th finger (HP:0004220)1.96967078
82Purpura (HP:0000979)1.96778641
83Childhood onset (HP:0011463)1.96137345
84Neoplasm of the oral cavity (HP:0100649)1.94074615
85Abnormality of pyrimidine metabolism (HP:0004353)1.91471322
86Aplasia/hypoplasia of the humerus (HP:0006507)1.91335941
87Abnormality of the columella (HP:0009929)1.89614942
88Reduced subcutaneous adipose tissue (HP:0003758)1.87629193
89Panhypogammaglobulinemia (HP:0003139)1.87259011
90Aplasia involving forearm bones (HP:0009822)1.86048120
91Absent forearm bone (HP:0003953)1.86048120
92Basal cell carcinoma (HP:0002671)1.86031937
93Macrocytic anemia (HP:0001972)1.84349678
94Visual hallucinations (HP:0002367)1.83608749
95Depression (HP:0000716)1.82401498
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80408906
97Increased mean platelet volume (HP:0011877)1.78866421
98Abnormal platelet volume (HP:0011876)1.76946239
99Seborrheic dermatitis (HP:0001051)1.76363089
100Abnormality of the carotid arteries (HP:0005344)1.75477336
101Papilloma (HP:0012740)1.74170347
102Verrucae (HP:0200043)1.74170347
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73906530
104Hypertriglyceridemia (HP:0002155)1.72209567
105Optic nerve coloboma (HP:0000588)1.72133026
106Anal stenosis (HP:0002025)1.70357062
107Thin skin (HP:0000963)1.69608161
108Synostosis of carpal bones (HP:0005048)1.68874948
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.68567011
110Autoimmune thrombocytopenia (HP:0001973)1.68374418
111Cafe-au-lait spot (HP:0000957)1.65729793
112Abnormality of chromosome stability (HP:0003220)1.64858169
113Decreased subcutaneous fat (HP:0001002)1.64321910
114Abnormal delayed hypersensitivity skin test (HP:0002963)1.63435198
115Abnormal blistering of the skin (HP:0008066)1.60902208
116Onion bulb formation (HP:0003383)1.60886932
117Neoplasm of the liver (HP:0002896)1.60500298
118Abnormal platelet function (HP:0011869)1.58868251
119Impaired platelet aggregation (HP:0003540)1.58868251
120Cutaneous melanoma (HP:0012056)1.58520109
121Hypoplastic iliac wings (HP:0002866)1.57441828
122High pitched voice (HP:0001620)1.56712587
123Abnormality of cochlea (HP:0000375)1.55053606
124Prenatal maternal abnormality (HP:0002686)1.54033066
125Meckel diverticulum (HP:0002245)1.50611663
126Broad palm (HP:0001169)1.50403498
127Hematochezia (HP:0002573)1.48629716
128Heterotopia (HP:0002282)1.48591552
129Hemorrhage of the eye (HP:0011885)1.47545042
130Abnormality of the preputium (HP:0100587)1.44710944
131Abnormality of the ileum (HP:0001549)1.44103663
132Bladder carcinoma (HP:0002862)1.43671019
133Bladder neoplasm (HP:0009725)1.43671019
134Small intestinal stenosis (HP:0012848)1.43157441
135Cortical visual impairment (HP:0100704)1.40225456
136Gastrointestinal dysmotility (HP:0002579)1.39210497
137Absent epiphyses (HP:0010577)1.37352125
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.37352125
139Pallor (HP:0000980)1.36218414
140Pancreatic islet-cell hyperplasia (HP:0004510)1.35281103
141Menorrhagia (HP:0000132)1.33013692
142Prominent nose (HP:0000448)1.32605952
143Deep venous thrombosis (HP:0002625)1.31171029
144Progressive microcephaly (HP:0000253)1.29947944
145Erythema (HP:0010783)1.28560278
146Breast hypoplasia (HP:0003187)1.27835883
147Short 5th finger (HP:0009237)1.27302760
148Abdominal pain (HP:0002027)1.26729760
149Thrombophlebitis (HP:0004418)1.26535649
150Hypopigmented skin patches (HP:0001053)1.25307783
151Anxiety (HP:0000739)1.24309659
152Psychosis (HP:0000709)1.23642094
153Lower limb amyotrophy (HP:0007210)1.23469698
154Gingival bleeding (HP:0000225)1.20929623
155Cortical dysplasia (HP:0002539)1.18793336
156Multiple enchondromatosis (HP:0005701)1.18410504
157Abnormality of chromosome segregation (HP:0002916)1.14294420
158Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.13674880
159Back pain (HP:0003418)1.13508104
160Impulsivity (HP:0100710)1.09976961
161Sacral dimple (HP:0000960)1.07014903
162Abnormality of dental color (HP:0011073)1.06749076
163Fragile skin (HP:0001030)1.04824506
164Status epilepticus (HP:0002133)1.04520304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK17.57298641
2TLK14.20779741
3STK43.69623774
4CDC73.57240050
5PRPF4B3.30104147
6CDK123.21678055
7BRSK12.70038517
8EEF2K2.59269357
9ZAK2.31661244
10TAOK22.29877838
11STK102.19463796
12MAP3K102.10817098
13NEK22.03743371
14STK161.91979409
15MAPK111.91181260
16WNK11.89137268
17NME21.83657740
18DYRK31.79733034
19MAP3K31.79342898
20GRK61.77498615
21PIM11.68908346
22RPS6KA51.60191354
23TRPM71.59283730
24MAP3K81.48688209
25VRK11.43640305
26BUB11.39315464
27AURKB1.33004278
28CDK61.32953309
29CDK41.32880554
30CHEK21.31333588
31TRIB31.31101939
32MAPKAPK31.29398874
33MAP3K111.28725273
34TAOK11.27939243
35AURKA1.26714495
36CDK91.22733386
37BRD41.22391137
38MELK1.21725045
39SCYL21.21569205
40RIPK41.16264580
41PKN21.14974942
42MAP2K41.14102037
43CDC42BPA1.10625808
44BLK1.09907496
45STK111.09729232
46MAP4K11.09117791
47GRK11.06838137
48TTK1.03535174
49MAP3K131.00045991
50MAP3K10.99828475
51ERBB20.99171214
52PLK20.96077602
53DYRK1B0.92876901
54CHEK10.91787310
55JAK20.90753455
56RPS6KA60.87739032
57PLK10.87386020
58GRK50.86888118
59TAOK30.86878156
60RPS6KB20.86636888
61BMX0.85815907
62RPS6KC10.84919264
63RPS6KL10.84919264
64MAPKAPK50.81369331
65PRKAA10.80978858
66* SYK0.77638218
67MAP2K20.75824131
68TGFBR20.74266539
69PRKD20.72262244
70CAMK1D0.72227849
71PBK0.71870938
72WEE10.70218201
73MAP2K30.70097035
74SGK30.70061608
75FGR0.68269462
76BRSK20.68227324
77PLK40.67647474
78CDK190.65316211
79ATR0.63883277
80TNK20.63378056
81CSK0.62206860
82STK240.61887751
83STK30.59910513
84MAP2K10.59731333
85PTK2B0.58696650
86* LYN0.57900309
87CDK20.57116710
88MAPKAPK20.55491665
89DAPK20.55084622
90CDK10.54844004
91ZAP700.54795958
92MAP3K50.54748145
93CLK10.53983571
94MAP3K60.53301358
95* ATM0.52962122
96TAF10.52408828
97FLT30.50667657
98MAP2K60.49976357
99BTK0.49113489
100ERN10.48327044
101SGK10.47705925
102TEC0.45808534
103PLK30.43579264
104FES0.43333888
105NEK10.43112764
106RPS6KA20.42739177
107IRAK40.42449441
108IKBKE0.41308491
109LRRK20.39339545
110SIK20.39195008
111MARK20.39047599
112CDK150.38899630
113PRKACG0.37913002
114ABL20.37650040
115MTOR0.37319224
116AKT10.36294069
117PRKAA20.36115636
118DYRK20.35464458
119SGK2230.35352119
120SGK4940.35352119
121CDK11A0.35073585
122GRK70.35071035
123AKT20.34992821
124MAPK140.34427667
125PRKCQ0.34128883
126DYRK1A0.33997011
127MAPK120.33469861
128TYK20.33461393
129CDK70.33096138
130SGK20.32979899
131NEK90.32792871
132RPS6KA10.32665643
133IKBKB0.32318605
134CDK180.32050154
135CHUK0.30893920
136CDK140.30653739
137MAPK30.30216812
138STK380.28446152
139MAPK80.28182468
140FRK0.28002018
141MARK30.27663166
142RPS6KA30.27504073
143HIPK20.27006566
144CAMK1G0.26202533
145PDK10.21762975
146PRKCB0.21298860
147ICK0.20392664

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008609.29471129
2Systemic lupus erythematosus_Homo sapiens_hsa053226.43320768
3Vitamin B6 metabolism_Homo sapiens_hsa007506.38136433
4Alcoholism_Homo sapiens_hsa050343.50449485
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64614940
6Cell cycle_Homo sapiens_hsa041102.61985148
7DNA replication_Homo sapiens_hsa030302.59555471
8African trypanosomiasis_Homo sapiens_hsa051432.11216416
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95925276
10Renin-angiotensin system_Homo sapiens_hsa046141.94607600
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89871073
12ABC transporters_Homo sapiens_hsa020101.80760338
13Viral carcinogenesis_Homo sapiens_hsa052031.77605197
14Renal cell carcinoma_Homo sapiens_hsa052111.67661558
15Hematopoietic cell lineage_Homo sapiens_hsa046401.61209017
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59434203
17Bladder cancer_Homo sapiens_hsa052191.57716553
18Malaria_Homo sapiens_hsa051441.44950495
19Sulfur relay system_Homo sapiens_hsa041221.38039332
20Non-small cell lung cancer_Homo sapiens_hsa052231.37590336
21One carbon pool by folate_Homo sapiens_hsa006701.30879068
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29974430
23Osteoclast differentiation_Homo sapiens_hsa043801.28246020
24Chronic myeloid leukemia_Homo sapiens_hsa052201.21577319
25p53 signaling pathway_Homo sapiens_hsa041151.20922461
26Glycerolipid metabolism_Homo sapiens_hsa005611.11554165
27Mismatch repair_Homo sapiens_hsa034301.06368224
28Nucleotide excision repair_Homo sapiens_hsa034201.05577160
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02799154
30Nitrogen metabolism_Homo sapiens_hsa009100.99422400
31Selenocompound metabolism_Homo sapiens_hsa004500.97677604
32Glycerophospholipid metabolism_Homo sapiens_hsa005640.96548115
33Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94788418
34Base excision repair_Homo sapiens_hsa034100.93681585
35Small cell lung cancer_Homo sapiens_hsa052220.92314223
36Primary immunodeficiency_Homo sapiens_hsa053400.92273747
37Apoptosis_Homo sapiens_hsa042100.87214698
38Pancreatic cancer_Homo sapiens_hsa052120.82727786
39Fanconi anemia pathway_Homo sapiens_hsa034600.82678704
40Asthma_Homo sapiens_hsa053100.79714718
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73031930
42Herpes simplex infection_Homo sapiens_hsa051680.71462626
43T cell receptor signaling pathway_Homo sapiens_hsa046600.71183867
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70981540
45Glioma_Homo sapiens_hsa052140.70851162
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69708388
47Homologous recombination_Homo sapiens_hsa034400.69314749
48mRNA surveillance pathway_Homo sapiens_hsa030150.68672594
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67047815
50Glutathione metabolism_Homo sapiens_hsa004800.66584837
51Oocyte meiosis_Homo sapiens_hsa041140.65064528
52Lysine degradation_Homo sapiens_hsa003100.64811396
53Complement and coagulation cascades_Homo sapiens_hsa046100.64757596
54Prolactin signaling pathway_Homo sapiens_hsa049170.63970501
55Hepatitis B_Homo sapiens_hsa051610.62631499
56Prostate cancer_Homo sapiens_hsa052150.61722967
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.61210526
58Spliceosome_Homo sapiens_hsa030400.59949449
59Dorso-ventral axis formation_Homo sapiens_hsa043200.59186079
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58887402
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58255341
62Leishmaniasis_Homo sapiens_hsa051400.56303565
63Nicotine addiction_Homo sapiens_hsa050330.56287325
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55373521
65HIF-1 signaling pathway_Homo sapiens_hsa040660.54464983
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54236595
67MicroRNAs in cancer_Homo sapiens_hsa052060.53832745
68Tuberculosis_Homo sapiens_hsa051520.53163469
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52722304
70RNA transport_Homo sapiens_hsa030130.51316589
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51289505
72AMPK signaling pathway_Homo sapiens_hsa041520.50198375
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50005538
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49158594
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48248746
76HTLV-I infection_Homo sapiens_hsa051660.46914718
77Fatty acid biosynthesis_Homo sapiens_hsa000610.45250849
78Inositol phosphate metabolism_Homo sapiens_hsa005620.42753510
79Measles_Homo sapiens_hsa051620.42170260
80FoxO signaling pathway_Homo sapiens_hsa040680.41772236
81TNF signaling pathway_Homo sapiens_hsa046680.41410942
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.41188697
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40189861
84Pyruvate metabolism_Homo sapiens_hsa006200.39958284
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39073541
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.38522002
87Notch signaling pathway_Homo sapiens_hsa043300.37813036
88Platelet activation_Homo sapiens_hsa046110.36684412
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.36386237
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.35861546
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35719054
92Bile secretion_Homo sapiens_hsa049760.35329200
93* Collecting duct acid secretion_Homo sapiens_hsa049660.35082261
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34973893
95Melanoma_Homo sapiens_hsa052180.33481153
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32529490
97Choline metabolism in cancer_Homo sapiens_hsa052310.31914728
98Toxoplasmosis_Homo sapiens_hsa051450.29450122
99Thyroid cancer_Homo sapiens_hsa052160.29114648
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29072429
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29059812
102Biosynthesis of amino acids_Homo sapiens_hsa012300.28438388
103Pentose phosphate pathway_Homo sapiens_hsa000300.28006630
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27011995
105Insulin resistance_Homo sapiens_hsa049310.25053386
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24818393
107Influenza A_Homo sapiens_hsa051640.22874868
108Non-homologous end-joining_Homo sapiens_hsa034500.19922973
109Epstein-Barr virus infection_Homo sapiens_hsa051690.17133270
110Antigen processing and presentation_Homo sapiens_hsa046120.17073538
111Hepatitis C_Homo sapiens_hsa051600.16184771
112Carbon metabolism_Homo sapiens_hsa012000.16023491
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.15541889
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15366045
115Pyrimidine metabolism_Homo sapiens_hsa002400.14002785
116Staphylococcus aureus infection_Homo sapiens_hsa051500.13891040
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13615905
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.13199571
119Fat digestion and absorption_Homo sapiens_hsa049750.12726942
120B cell receptor signaling pathway_Homo sapiens_hsa046620.12278113
121Acute myeloid leukemia_Homo sapiens_hsa052210.11241361
122Insulin signaling pathway_Homo sapiens_hsa049100.10966472
123Endocytosis_Homo sapiens_hsa041440.08841111
124Gap junction_Homo sapiens_hsa045400.08341750
125Tryptophan metabolism_Homo sapiens_hsa003800.07083323
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.06942518
127Chemokine signaling pathway_Homo sapiens_hsa040620.06194083
128RNA degradation_Homo sapiens_hsa030180.05627853
129beta-Alanine metabolism_Homo sapiens_hsa004100.05578533
130Arginine biosynthesis_Homo sapiens_hsa002200.05500862
131Type II diabetes mellitus_Homo sapiens_hsa049300.05103648
132Ribosome_Homo sapiens_hsa030100.04806211
133mTOR signaling pathway_Homo sapiens_hsa041500.04144737
134Metabolic pathways_Homo sapiens_hsa011000.04123278
135Regulation of autophagy_Homo sapiens_hsa041400.03866725
136Endometrial cancer_Homo sapiens_hsa052130.03675882
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.02701757

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »