SLC4A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.31209751
2Golgi transport vesicle coating (GO:0048200)5.31209751
3protein retention in ER lumen (GO:0006621)4.07333907
4regulation of glucose import in response to insulin stimulus (GO:2001273)3.83933641
5proline biosynthetic process (GO:0006561)3.71670081
6activation of Rac GTPase activity (GO:0032863)3.68652405
7negative regulation of cell size (GO:0045792)3.62849246
8apoptotic cell clearance (GO:0043277)3.60876964
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.60661251
10planar cell polarity pathway involved in neural tube closure (GO:0090179)3.60613512
11cell-substrate adherens junction assembly (GO:0007045)3.59531141
12focal adhesion assembly (GO:0048041)3.59531141
13apoptotic process involved in morphogenesis (GO:0060561)3.58665681
14protein localization to endosome (GO:0036010)3.49307986
15protein heterotrimerization (GO:0070208)3.46126902
16skin morphogenesis (GO:0043589)3.43997590
17myelin maintenance (GO:0043217)3.43747624
18hemidesmosome assembly (GO:0031581)3.42868844
19cell adhesion mediated by integrin (GO:0033627)3.39251392
20pentose-phosphate shunt (GO:0006098)3.38523425
21glucose 6-phosphate metabolic process (GO:0051156)3.34407161
22regulation of mammary gland epithelial cell proliferation (GO:0033599)3.31718996
23desmosome organization (GO:0002934)3.29263007
24endodermal cell differentiation (GO:0035987)3.27933566
25glucose catabolic process (GO:0006007)3.27571525
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.26981038
27regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.18647307
28virion attachment to host cell (GO:0019062)3.16783293
29adhesion of symbiont to host cell (GO:0044650)3.16783293
30barbed-end actin filament capping (GO:0051016)3.14942702
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.14181404
32mannose metabolic process (GO:0006013)3.13365211
33regulation of translational fidelity (GO:0006450)3.07629534
34negative regulation of fatty acid transport (GO:2000192)3.04782015
35low-density lipoprotein particle clearance (GO:0034383)3.03216293
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.02881216
37growth hormone receptor signaling pathway (GO:0060396)3.01870564
38maternal placenta development (GO:0001893)3.00627849
39adhesion of symbiont to host (GO:0044406)2.94950661
40NADPH regeneration (GO:0006740)2.92552871
41collagen fibril organization (GO:0030199)2.92275854
42cytoskeletal anchoring at plasma membrane (GO:0007016)2.89952062
43chondrocyte proliferation (GO:0035988)2.86426065
44positive regulation of blood vessel endothelial cell migration (GO:0043536)2.84573747
45regulation of cholesterol homeostasis (GO:2000188)2.84356000
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83016880
47branching involved in mammary gland duct morphogenesis (GO:0060444)2.81016343
48mitotic chromosome condensation (GO:0007076)2.80359315
49epithelial cell-cell adhesion (GO:0090136)2.79691098
50cellular response to vitamin (GO:0071295)2.79173741
51stress fiber assembly (GO:0043149)2.79112635
52cell-substrate junction assembly (GO:0007044)2.78814038
53positive regulation of Cdc42 GTPase activity (GO:0043089)2.76696694
54negative regulation of erythrocyte differentiation (GO:0045647)2.75891467
55vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.75358111
56response to laminar fluid shear stress (GO:0034616)2.74736161
57pinocytosis (GO:0006907)2.73567325
58positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72335222
59basement membrane organization (GO:0071711)2.72161618
60endothelial cell morphogenesis (GO:0001886)2.70351135
61positive regulation of p38MAPK cascade (GO:1900745)2.68337858
62positive regulation of receptor recycling (GO:0001921)2.66462945
63cell-cell junction maintenance (GO:0045217)2.66295186
64endothelial cell chemotaxis (GO:0035767)2.63898669
65protein maturation by protein folding (GO:0022417)2.61560117
66establishment of apical/basal cell polarity (GO:0035089)2.60217946
67cellular response to growth hormone stimulus (GO:0071378)2.59865873
68collagen metabolic process (GO:0032963)2.58756701
69extracellular matrix disassembly (GO:0022617)2.58371358
70DNA unwinding involved in DNA replication (GO:0006268)2.57751003
71collagen catabolic process (GO:0030574)2.55280975
72cortical actin cytoskeleton organization (GO:0030866)2.55135832
73multicellular organismal catabolic process (GO:0044243)2.54090236
74proline metabolic process (GO:0006560)2.54069729
75glomerular basement membrane development (GO:0032836)2.53336207
76retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52585681
77cellular protein complex localization (GO:0034629)2.52250168
78protein hydroxylation (GO:0018126)2.52136499
79renal filtration (GO:0097205)2.51883460
80embryonic process involved in female pregnancy (GO:0060136)2.51249264
81cellular response to vitamin D (GO:0071305)2.51013736
82ER-nucleus signaling pathway (GO:0006984)2.50531656
83regulation of apoptotic process involved in morphogenesis (GO:1902337)2.49548122
84multicellular organismal macromolecule metabolic process (GO:0044259)2.48629958
85epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47399196
86regulation of nuclease activity (GO:0032069)2.45949201
87membrane protein ectodomain proteolysis (GO:0006509)2.45498195
88hyaluronan catabolic process (GO:0030214)2.45285301
89regulation of membrane protein ectodomain proteolysis (GO:0051043)2.44529347
90regulation of fatty acid beta-oxidation (GO:0031998)2.44273316
91multicellular organismal metabolic process (GO:0044236)2.43960965
92negative regulation of viral release from host cell (GO:1902187)2.41818859
93endocardial cushion development (GO:0003197)2.39626863
94glomerular visceral epithelial cell development (GO:0072015)2.38261351
95embryonic eye morphogenesis (GO:0048048)2.37705698
96embryo implantation (GO:0007566)2.36522472
97positive regulation of fatty acid beta-oxidation (GO:0032000)2.36512810
98cellular response to unfolded protein (GO:0034620)2.36494207
99regulation of integrin activation (GO:0033623)2.35898950
100regulation of p38MAPK cascade (GO:1900744)2.34354449
101positive regulation of endothelial cell apoptotic process (GO:2000353)2.33950639
102diaphragm development (GO:0060539)2.33845926
103regulation of NFAT protein import into nucleus (GO:0051532)2.33812754
104response to lipoprotein particle (GO:0055094)2.33257618
105alpha-linolenic acid metabolic process (GO:0036109)2.33201219
106endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.33074192
107response to fluid shear stress (GO:0034405)2.32862319
108positive regulation of extracellular matrix organization (GO:1903055)2.32250070
109vesicle coating (GO:0006901)2.32153232
110convergent extension (GO:0060026)2.31748150
111positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.31561932
112adherens junction assembly (GO:0034333)2.31327289
113regulation of cholesterol storage (GO:0010885)2.31235996
114semaphorin-plexin signaling pathway (GO:0071526)2.30916545
115creatine metabolic process (GO:0006600)2.30740653
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.30606186
117receptor catabolic process (GO:0032801)2.30273798
118regulation of histone H3-K27 methylation (GO:0061085)2.30113582
119UV protection (GO:0009650)2.29778933
120apoptotic process involved in development (GO:1902742)2.29020150
121regulation of cholesterol biosynthetic process (GO:0045540)2.28580729
122cellular response to epidermal growth factor stimulus (GO:0071364)2.27701812
123intestinal cholesterol absorption (GO:0030299)2.27614865
124iron ion import (GO:0097286)2.27562142
125positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25760753
126cellular response to nutrient (GO:0031670)2.25030617
127vascular endothelial growth factor signaling pathway (GO:0038084)2.24880640
128regulation of extracellular matrix disassembly (GO:0010715)2.23294233
129activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.23040198
130sulfur amino acid catabolic process (GO:0000098)2.22992860
131mesodermal cell differentiation (GO:0048333)2.22171556
132amyloid precursor protein catabolic process (GO:0042987)2.21996121
133regulation of early endosome to late endosome transport (GO:2000641)2.20646140
134peptidyl-proline hydroxylation (GO:0019511)2.20515196
135negative regulation of smooth muscle cell migration (GO:0014912)2.19265840
136extracellular matrix assembly (GO:0085029)2.18797278
137positive regulation of histone deacetylation (GO:0031065)2.18735951
138actin filament depolymerization (GO:0030042)2.18464183
139glomerular epithelial cell development (GO:0072310)2.18337450
140platelet-derived growth factor receptor signaling pathway (GO:0048008)2.16958596
141intestinal absorption (GO:0050892)2.16658728
142positive regulation of Rho protein signal transduction (GO:0035025)2.16121015
143negative regulation of lipid transport (GO:0032369)2.14617172
144cortical cytoskeleton organization (GO:0030865)2.14488407
145integrin-mediated signaling pathway (GO:0007229)2.13693936
146wound healing, spreading of epidermal cells (GO:0035313)2.12675787
147negative regulation of fibrinolysis (GO:0051918)2.12197679
148cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.12105379
149germ cell migration (GO:0008354)2.11849745
150substrate adhesion-dependent cell spreading (GO:0034446)2.11292430
151branching involved in salivary gland morphogenesis (GO:0060445)2.11154517
152membrane raft organization (GO:0031579)2.07804363
153insulin-like growth factor receptor signaling pathway (GO:0048009)2.07741267
154bundle of His cell to Purkinje myocyte communication (GO:0086069)2.07336705
155positive regulation of osteoblast proliferation (GO:0033690)2.05297382
156positive regulation of nuclease activity (GO:0032075)2.04925400
157regulation of cholesterol metabolic process (GO:0090181)2.04638472
158glomerular filtration (GO:0003094)2.03248557
159endoplasmic reticulum unfolded protein response (GO:0030968)2.02775797
160maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.02059776
161peptidyl-glutamic acid carboxylation (GO:0017187)2.01398110
162protein carboxylation (GO:0018214)2.01398110
163atrioventricular valve morphogenesis (GO:0003181)2.01241930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.05365727
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.36924455
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.27115183
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.87535864
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53929927
6E2F7_22180533_ChIP-Seq_HELA_Human2.52186852
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49858323
8CLOCK_20551151_ChIP-Seq_293T_Human2.44004563
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33148890
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.29206345
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.28001143
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26835201
13MYC_22102868_ChIP-Seq_BL_Human2.25340140
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.21147136
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.18764011
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.18042673
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.17242058
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02506550
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.94332544
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90418878
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.86661137
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85982472
23* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.85496112
24RACK7_27058665_Chip-Seq_MCF-7_Human1.83480392
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.77740416
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77689662
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.76735182
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76520375
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76202562
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74304184
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71596158
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.68846310
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68652602
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64542875
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62330043
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61498013
37LXR_22292898_ChIP-Seq_THP-1_Human1.59121954
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59051783
39* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58743572
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53510263
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53161580
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.52088468
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49493098
44* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47908276
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46011041
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.45927700
47KDM2B_26808549_Chip-Seq_DND41_Human1.45518947
48CDX2_20551321_ChIP-Seq_CACO-2_Human1.45108101
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44242504
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43961813
51SOX2_20726797_ChIP-Seq_SW620_Human1.42491966
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41856292
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41348722
54TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40367383
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39743168
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.39051804
57* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38326017
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38212648
59* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36963386
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35509037
61TBX20_22080862_ChIP-Seq_HEART_Mouse1.35228389
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.35228389
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34642388
64ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34545474
65CJUN_26792858_Chip-Seq_BT549_Human1.34291804
66ATF3_27146783_Chip-Seq_COLON_Human1.34195890
67* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33573411
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33555040
69GATA6_25053715_ChIP-Seq_YYC3_Human1.32920282
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32468421
71* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32457796
72* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32457796
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31632796
74GATA4_25053715_ChIP-Seq_YYC3_Human1.30807027
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30185537
76* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29781382
77NCOR1_26117541_ChIP-Seq_K562_Human1.29669505
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.29308976
79P68_20966046_ChIP-Seq_HELA_Human1.29238833
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.28808820
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28636081
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28455361
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28073037
84* KDM2B_26808549_Chip-Seq_K562_Human1.26856032
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24681489
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23347252
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.23316132
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22743676
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22008717
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21734425
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.20631797
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.20234803
93TP53_22127205_ChIP-Seq_IMR90_Human1.20211648
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20105068
95SMC4_20622854_ChIP-Seq_HELA_Human1.19266629
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.19131802
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18418876
98VDR_21846776_ChIP-Seq_THP-1_Human1.18384198
99MYC_18555785_ChIP-Seq_MESCs_Mouse1.17351572
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17317833
101KLF5_25053715_ChIP-Seq_YYC3_Human1.17122245
102TCF7_22412390_ChIP-Seq_EML_Mouse1.16795492
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15556910
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15452582
105GATA1_19941826_ChIP-Seq_K562_Human1.15185932
106CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14612665
107NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12035566
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11695668
109FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11142928
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10973291
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10251917
112* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10247831
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09481913
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08281865
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08078816
116SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06570543
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04997083
118UBF1/2_26484160_Chip-Seq_HMECs_Human1.03734096
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.03431247
120NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02562553
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02487337
122MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02061971
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01659742
124NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01659742
125CREB1_26743006_Chip-Seq_LNCaP_Human1.01430980
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01060885
127ZNF263_19887448_ChIP-Seq_K562_Human1.00816278
128VDR_24763502_ChIP-Seq_THP-1_Human1.00751311
129MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00274616
130NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99791461
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99523985
132BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99354977
133SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99084369
134AR_21909140_ChIP-Seq_LNCAP_Human0.98155443
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98035795
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97728791
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97680265
138XRN2_22483619_ChIP-Seq_HELA_Human0.97196857
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96835648
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96680998
141SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96168651
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.95675502
143GATA2_19941826_ChIP-Seq_K562_Human0.94778696
144RUNX1_22412390_ChIP-Seq_EML_Mouse0.94406102
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94178759
146MAF_26560356_Chip-Seq_TH1_Human0.93848377
147* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92402531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.24462588
2MP0003705_abnormal_hypodermis_morpholog3.90598731
3MP0005451_abnormal_body_composition3.05625625
4MP0005275_abnormal_skin_tensile2.85404385
5MP0003300_gastrointestinal_ulcer2.77407502
6MP0001958_emphysema2.60138956
7MP0009384_cardiac_valve_regurgitation2.34686567
8MP0003566_abnormal_cell_adhesion2.26883349
9MP0004272_abnormal_basement_membrane2.15332762
10MP0005503_abnormal_tendon_morphology2.09530507
11MP0005623_abnormal_meninges_morphology2.09522673
12MP0006054_spinal_hemorrhage2.07252042
13MP0003279_aneurysm2.06826114
14MP0004858_abnormal_nervous_system2.02525767
15MP0004233_abnormal_muscle_weight1.88589551
16MP0000678_abnormal_parathyroid_gland1.88324897
17MP0009840_abnormal_foam_cell1.82199383
18MP0001849_ear_inflammation1.81600517
19MP0003091_abnormal_cell_migration1.79677318
20MP0002060_abnormal_skin_morphology1.79363519
21MP0008004_abnormal_stomach_pH1.75293724
22MP0002139_abnormal_hepatobiliary_system1.74323258
23MP0008260_abnormal_autophagy1.74230968
24MP0005409_darkened_coat_color1.73455048
25MP0010352_gastrointestinal_tract_polyps1.70912913
26MP0005058_abnormal_lysosome_morphology1.69702748
27MP0003045_fibrosis1.66139898
28MP0005023_abnormal_wound_healing1.65518444
29MP0005360_urolithiasis1.65168148
30MP0003252_abnormal_bile_duct1.61511354
31MP0001666_abnormal_nutrient_absorption1.60745890
32MP0000733_abnormal_muscle_development1.60585223
33MP0000537_abnormal_urethra_morphology1.59436432
34MP0005257_abnormal_intraocular_pressure1.52398292
35MP0002877_abnormal_melanocyte_morpholog1.48496378
36MP0002796_impaired_skin_barrier1.48403433
37MP0010234_abnormal_vibrissa_follicle1.43895127
38MP0003453_abnormal_keratinocyte_physiol1.41729990
39MP0003191_abnormal_cellular_cholesterol1.41464285
40MP0005083_abnormal_biliary_tract1.37733415
41MP0002249_abnormal_larynx_morphology1.36027156
42MP0005377_hearing/vestibular/ear_phenot1.35258196
43MP0003878_abnormal_ear_physiology1.35258196
44MP0000858_altered_metastatic_potential1.33949599
45MP0004185_abnormal_adipocyte_glucose1.33142527
46MP0005501_abnormal_skin_physiology1.31249153
47MP0000003_abnormal_adipose_tissue1.30632393
48MP0003195_calcinosis1.29552310
49MP0002896_abnormal_bone_mineralization1.28969520
50MP0000462_abnormal_digestive_system1.25363875
51MP0000751_myopathy1.23169313
52MP0001243_abnormal_dermal_layer1.22697208
53MP0002933_joint_inflammation1.20978359
54MP0004947_skin_inflammation1.18389538
55MP0002295_abnormal_pulmonary_circulatio1.18055245
56MP0005508_abnormal_skeleton_morphology1.17341664
57MP0001730_embryonic_growth_arrest1.16654173
58MP0003283_abnormal_digestive_organ1.12737188
59MP0002168_other_aberrant_phenotype1.12408395
60MP0000767_abnormal_smooth_muscle1.11323419
61MP0003303_peritoneal_inflammation1.08695983
62MP0005365_abnormal_bile_salt1.07230373
63MP0005375_adipose_tissue_phenotype1.03708000
64MP0005076_abnormal_cell_differentiation1.02815557
65MP0002998_abnormal_bone_remodeling1.02245854
66MP0009278_abnormal_bone_marrow1.01858853
67MP0000013_abnormal_adipose_tissue1.01773865
68MP0005621_abnormal_cell_physiology0.98324494
69MP0004264_abnormal_extraembryonic_tissu0.97668369
70MP0003111_abnormal_nucleus_morphology0.97624713
71MP0005171_absent_coat_pigmentation0.95941354
72MP0000920_abnormal_myelination0.95540103
73MP0001216_abnormal_epidermal_layer0.95359175
74MP0001533_abnormal_skeleton_physiology0.94239216
75MP0003115_abnormal_respiratory_system0.93610447
76MP0000747_muscle_weakness0.92777509
77MP0005085_abnormal_gallbladder_physiolo0.92431674
78MP0010155_abnormal_intestine_physiology0.90420715
79MP0000759_abnormal_skeletal_muscle0.90335777
80MP0005167_abnormal_blood-brain_barrier0.89172119
81MP0010630_abnormal_cardiac_muscle0.88440895
82MP0003942_abnormal_urinary_system0.88412990
83MP0000566_synostosis0.88075651
84MP0002086_abnormal_extraembryonic_tissu0.87829110
85MP0000762_abnormal_tongue_morphology0.86407676
86MP0006138_congestive_heart_failure0.85512066
87MP0009643_abnormal_urine_homeostasis0.85410045
88MP0010030_abnormal_orbit_morphology0.83973544
89MP0010678_abnormal_skin_adnexa0.83734558
90MP0005666_abnormal_adipose_tissue0.83619249
91MP0002080_prenatal_lethality0.83397905
92MP0009780_abnormal_chondrocyte_physiolo0.82124178
93MP0004782_abnormal_surfactant_physiolog0.81679574
94MP0010368_abnormal_lymphatic_system0.80267880
95MP0001299_abnormal_eye_distance/0.80140697
96MP0005390_skeleton_phenotype0.80033262
97MP0000477_abnormal_intestine_morphology0.79920905
98MP0004808_abnormal_hematopoietic_stem0.79796305
99MP0004134_abnormal_chest_morphology0.79735483
100MP0009053_abnormal_anal_canal0.78506937
101MP0010329_abnormal_lipoprotein_level0.78357050
102MP0009672_abnormal_birth_weight0.78326687
103MP0001348_abnormal_lacrimal_gland0.77513724
104MP0003984_embryonic_growth_retardation0.76525543
105MP0003690_abnormal_glial_cell0.75056766
106MP0002115_abnormal_skeleton_extremities0.73957650
107MP0009931_abnormal_skin_appearance0.73924211
108MP0005330_cardiomyopathy0.73338488
109MP0005197_abnormal_uvea_morphology0.73274853
110MP0000350_abnormal_cell_proliferation0.73263856
111MP0003329_amyloid_beta_deposits0.72912111
112MP0003866_abnormal_defecation0.72799211
113MP0006082_CNS_inflammation0.72642541
114MP0002128_abnormal_blood_circulation0.72564887
115MP0005380_embryogenesis_phenotype0.72159664
116MP0001672_abnormal_embryogenesis/_devel0.72159664
117MP0000163_abnormal_cartilage_morphology0.72068653
118MP0002108_abnormal_muscle_morphology0.71761829
119MP0000750_abnormal_muscle_regeneration0.71604739
120MP0001661_extended_life_span0.71433278
121MP0004087_abnormal_muscle_fiber0.71416102
122MP0003385_abnormal_body_wall0.71166088
123MP0001915_intracranial_hemorrhage0.70585546
124MP0003806_abnormal_nucleotide_metabolis0.70110407
125MP0003172_abnormal_lysosome_physiology0.70102515
126MP0002088_abnormal_embryonic_growth/wei0.69805323
127MP0000609_abnormal_liver_physiology0.69714713
128MP0005670_abnormal_white_adipose0.69637743
129MP0003950_abnormal_plasma_membrane0.68751021
130MP0000579_abnormal_nail_morphology0.68739493
131MP0002098_abnormal_vibrissa_morphology0.68610665
132MP0001614_abnormal_blood_vessel0.67697731
133MP0000428_abnormal_craniofacial_morphol0.67624962
134MP0002118_abnormal_lipid_homeostasis0.67506267
135MP0004510_myositis0.67366118
136MP0005381_digestive/alimentary_phenotyp0.67182802
137MP0002166_altered_tumor_susceptibility0.67028627
138MP0002269_muscular_atrophy0.66861192
139MP0003795_abnormal_bone_structure0.66814723
140MP0001873_stomach_inflammation0.66376894
141MP0001879_abnormal_lymphatic_vessel0.66023406
142MP0004130_abnormal_muscle_cell0.65989627
143MP0002089_abnormal_postnatal_growth/wei0.65924545
144MP0005384_cellular_phenotype0.65576584
145MP0000534_abnormal_ureter_morphology0.65373191
146MP0001542_abnormal_bone_strength0.63251272
147MP0008875_abnormal_xenobiotic_pharmacok0.63007179

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.49845418
2Protrusio acetabuli (HP:0003179)4.89790764
3Atrophic scars (HP:0001075)4.03256063
4Cerebral aneurysm (HP:0004944)3.74088240
5Aortic dissection (HP:0002647)3.73639759
6Shallow orbits (HP:0000586)3.68515992
7Broad metatarsal (HP:0001783)3.65455215
8Peritonitis (HP:0002586)3.56247835
9Fragile skin (HP:0001030)3.35280351
10Aortic aneurysm (HP:0004942)3.31484134
11Thin bony cortex (HP:0002753)3.25876876
12Ankle contracture (HP:0006466)3.25555349
13Broad face (HP:0000283)3.09659485
14Bladder diverticulum (HP:0000015)2.91213572
15Achilles tendon contracture (HP:0001771)2.83265553
16Distal upper limb amyotrophy (HP:0007149)2.80304590
17Upper limb amyotrophy (HP:0009129)2.80304590
18Cervical subluxation (HP:0003308)2.79602567
19Neonatal short-limb short stature (HP:0008921)2.79263265
20Osteolytic defects of the hand bones (HP:0009699)2.76076596
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.76076596
22Ulnar bowing (HP:0003031)2.74016143
23Mitral valve prolapse (HP:0001634)2.70255484
24Right ventricular cardiomyopathy (HP:0011663)2.65939564
25Flat acetabular roof (HP:0003180)2.63031275
26Abnormality of the Achilles tendon (HP:0005109)2.59607160
27Stridor (HP:0010307)2.59370203
28Blue sclerae (HP:0000592)2.58633622
29Distal lower limb muscle weakness (HP:0009053)2.54912133
30Dilatation of the ascending aorta (HP:0005111)2.54023988
31Increased connective tissue (HP:0009025)2.53128921
32Soft skin (HP:0000977)2.52251616
33Myocardial infarction (HP:0001658)2.47255379
34Disproportionate tall stature (HP:0001519)2.47141654
35J-shaped sella turcica (HP:0002680)2.44584837
36Wormian bones (HP:0002645)2.42462625
37Mildly elevated creatine phosphokinase (HP:0008180)2.39733222
38Aneurysm (HP:0002617)2.37498185
39Hand muscle atrophy (HP:0009130)2.27512242
40Vertebral compression fractures (HP:0002953)2.26326087
41Insomnia (HP:0100785)2.25578440
42Tibial bowing (HP:0002982)2.23401591
43Asymmetry of the thorax (HP:0001555)2.22155442
44Deep venous thrombosis (HP:0002625)2.19867081
45Turricephaly (HP:0000262)2.17855749
46Genu recurvatum (HP:0002816)2.17851843
47Cardiovascular calcification (HP:0011915)2.16973186
48Scapular winging (HP:0003691)2.16020123
49Trismus (HP:0000211)2.15006210
50Hemorrhage of the eye (HP:0011885)2.12505785
51Type 1 muscle fiber predominance (HP:0003803)2.11718170
52Hyporeflexia of lower limbs (HP:0002600)2.10419346
53Vascular tortuosity (HP:0004948)2.09202448
54Hyperextensible skin (HP:0000974)2.08365475
55Femoral bowing (HP:0002980)2.06583491
56Focal segmental glomerulosclerosis (HP:0000097)2.05172829
57Nuclear cataract (HP:0100018)2.04441111
58Long palpebral fissure (HP:0000637)2.03862555
59Spinal rigidity (HP:0003306)2.02432342
60Ectopia lentis (HP:0001083)2.01685345
61Lower limb amyotrophy (HP:0007210)2.01043578
62Ileus (HP:0002595)1.99584254
63Centrally nucleated skeletal muscle fibers (HP:0003687)1.98551188
64Bowing of the arm (HP:0006488)1.97876819
65Bowed forearm bones (HP:0003956)1.97876819
66Deviation of the hallux (HP:0010051)1.95791119
67Milia (HP:0001056)1.95393521
68Arterial tortuosity (HP:0005116)1.93805158
69Abnormality of dentin (HP:0010299)1.93720635
70Generalized amyotrophy (HP:0003700)1.93293678
71Cholecystitis (HP:0001082)1.92553165
72Abnormal gallbladder physiology (HP:0012438)1.92553165
73Short nail (HP:0001799)1.92103123
74Follicular hyperkeratosis (HP:0007502)1.91224511
75Abnormality of oral frenula (HP:0000190)1.91163996
76Nonimmune hydrops fetalis (HP:0001790)1.90896996
77Hallux valgus (HP:0001822)1.90714641
78Increased variability in muscle fiber diameter (HP:0003557)1.90531462
79Abnormal delivery (HP:0001787)1.89790562
80Mitral regurgitation (HP:0001653)1.88929570
81Alopecia of scalp (HP:0002293)1.88390044
82Vascular calcification (HP:0004934)1.88285478
83Abnormality of the acetabulum (HP:0003170)1.87395259
84Infantile muscular hypotonia (HP:0008947)1.87334326
85Selective tooth agenesis (HP:0001592)1.87233440
86Ankyloglossia (HP:0010296)1.86960694
87Axonal loss (HP:0003447)1.86342030
88Coronal craniosynostosis (HP:0004440)1.86225212
89Renal duplication (HP:0000075)1.86216174
90Advanced eruption of teeth (HP:0006288)1.86065942
91Biconcave vertebral bodies (HP:0004586)1.85735198
92Patellar dislocation (HP:0002999)1.85524884
93Distal lower limb amyotrophy (HP:0008944)1.84888396
94Cupped ribs (HP:0000887)1.84413587
95Natal tooth (HP:0000695)1.82700842
96Abnormal vertebral ossification (HP:0100569)1.80850826
97Elbow flexion contracture (HP:0002987)1.80276381
98Xanthomatosis (HP:0000991)1.77022060
99Hydroxyprolinuria (HP:0003080)1.76344323
100Abnormality of proline metabolism (HP:0010907)1.76344323
101Elfin facies (HP:0004428)1.74358199
102Abnormality of the umbilical cord (HP:0010881)1.74160533
103Premature skin wrinkling (HP:0100678)1.73251699
104Long toe (HP:0010511)1.72931400
105Abnormality of the thoracic spine (HP:0100711)1.72927391
106Buphthalmos (HP:0000557)1.71942940
107Abnormality of liposaccharide metabolism (HP:0010968)1.71759726
108Abnormality of glycosphingolipid metabolism (HP:0004343)1.71759726
109Abnormality of glycolipid metabolism (HP:0010969)1.71759726
110Glomerulosclerosis (HP:0000096)1.71699524
111Abnormality of carpal bone ossification (HP:0006257)1.71034494
112Reticulocytosis (HP:0001923)1.70682626
113Muscle fiber splitting (HP:0003555)1.70502203
114Overriding aorta (HP:0002623)1.69691223
115Wide anterior fontanel (HP:0000260)1.69518937
116Abnormal ossification of hand bones (HP:0005921)1.69286102
117Lymphangioma (HP:0100764)1.68658130
118Coxa vara (HP:0002812)1.67722311
119Camptodactyly of toe (HP:0001836)1.67637813
120Broad distal phalanx of finger (HP:0009836)1.67415946
121Difficulty climbing stairs (HP:0003551)1.67323005
122Abnormal foot bone ossification (HP:0010675)1.67219595
123Increased cerebral lipofuscin (HP:0011813)1.66728416
124Abnormality of the tricuspid valve (HP:0001702)1.66576735
125Abdominal distention (HP:0003270)1.66409262
126Dysostosis multiplex (HP:0000943)1.66343045
127Bowel diverticulosis (HP:0005222)1.65617469
128Obstructive sleep apnea (HP:0002870)1.65134440
129Hyperparathyroidism (HP:0000843)1.63916370
130Hyperacusis (HP:0010780)1.63894021
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.63768407
132Thin ribs (HP:0000883)1.63558008
133Congenital glaucoma (HP:0001087)1.63384513
134Mitral stenosis (HP:0001718)1.62528642
135Urinary glycosaminoglycan excretion (HP:0003541)1.62421294
136Mucopolysacchariduria (HP:0008155)1.62421294
137Abnormality of the peritoneum (HP:0002585)1.62169892
138Spinal cord compression (HP:0002176)1.61839389
139Easy fatigability (HP:0003388)1.61355683
140Joint stiffness (HP:0001387)1.60558010
141Abnormality of the distal phalanges of the toes (HP:0010182)1.59462142
142Back pain (HP:0003418)1.59245367
143Bell-shaped thorax (HP:0001591)1.59093192
144Nephritis (HP:0000123)1.57969732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.40977112
2IRAK33.86660093
3SMG13.12417316
4TTN2.92776775
5EPHB12.92512218
6DDR22.87119316
7ERN12.77205049
8PKN22.66498533
9PTK62.64481845
10PDGFRA2.44121996
11NME22.36186978
12RIPK12.23132096
13SIK12.19497876
14PRPF4B2.10305586
15MET1.91229415
16EEF2K1.79812832
17BMX1.69441686
18LATS11.69350312
19ICK1.68265937
20MST1R1.61645797
21TRPM71.57780216
22PTK21.54099639
23MAP3K101.53425957
24STK391.47175360
25LRRK21.46644489
26TGFBR21.42048686
27FGFR41.40774002
28LATS21.39325188
29MAP2K21.38765489
30EPHB21.37943946
31WNK41.34350584
32PAK41.33683031
33EPHA31.33596706
34LMTK21.29469860
35PAK21.27702764
36WNK11.26416806
37PDGFRB1.23833322
38EPHA21.23341460
39FGFR21.22431215
40CAMK1D1.20144532
41TAOK21.18626092
42MAP2K31.16360660
43CDK121.13983924
44DMPK1.06095025
45IRAK21.03885508
46SCYL21.00530608
47PRKG20.98911085
48CAMK1G0.97108606
49TYRO30.95296410
50MTOR0.95236141
51RPS6KB20.94557364
52TESK10.93798185
53JAK10.93082219
54PRKD10.92455285
55TBK10.91755842
56STK100.91613082
57LIMK10.91265209
58ARAF0.88059915
59MAP3K70.83505024
60FER0.82794374
61RPS6KA20.82162329
62CSK0.81950731
63KSR20.79185134
64FRK0.77961667
65CDK70.77525750
66STK30.77246949
67MYLK0.75154826
68ROCK20.73795466
69MAP3K110.73077358
70TYK20.72032263
71PRKCH0.70703747
72MAPKAPK30.69971534
73DYRK1B0.69715963
74TESK20.69110659
75ERBB40.68103936
76PIK3CA0.67899099
77PAK30.67509464
78CDC42BPA0.67426503
79PIM20.67361687
80MAP3K130.66674102
81NEK90.66488763
82CDK80.66377271
83MAPK110.66298344
84PRKD20.65374504
85FGFR30.65213005
86MAP3K60.64912839
87ROCK10.64619288
88DAPK30.63966152
89JAK30.63948234
90PDPK10.61942011
91IRAK40.61774100
92RET0.60101269
93TAOK10.59856153
94MOS0.59382119
95ILK0.58555267
96GSK3A0.58325043
97CDK60.56826946
98MATK0.56507146
99FGFR10.56010176
100BRAF0.55982934
101PTK2B0.55742478
102FGR0.55538151
103CDK40.55512329
104MARK20.54953736
105MAP2K10.53626024
106RPS6KL10.53342951
107RPS6KC10.53342951
108PRKD30.52102918
109MAP4K10.51454130
110NTRK10.50041443
111PRKAA20.48812949
112MAP3K80.47695586
113MAP3K30.47479515
114INSR0.46794939
115ITK0.45986292
116CHUK0.44517460
117SRC0.44231883
118CSF1R0.43469694
119CSNK1A1L0.43364577
120MAP3K140.42902099
121PKN10.42872560
122OXSR10.42525422
123ZAP700.42378452
124AKT20.41604189
125MAPKAPK20.40599661
126STK380.39677677
127ERBB20.39188260
128CDK90.38626305
129CLK10.38276301
130MAP3K10.37675049
131CAMKK10.36990775
132PIK3CG0.36846061
133ABL10.36595558
134JAK20.35983208
135MAP3K20.35927863
136PAK10.35276099
137PRKCI0.34614444
138ABL20.33473069
139HIPK20.32567124
140MELK0.31713771
141RPS6KA60.31105391
142AURKA0.29734857
143CAMK2G0.25208991

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.33627079
2Sulfur metabolism_Homo sapiens_hsa009202.26556972
3Nitrogen metabolism_Homo sapiens_hsa009102.18582751
4Pentose phosphate pathway_Homo sapiens_hsa000302.07619193
5Fructose and mannose metabolism_Homo sapiens_hsa000511.97699860
6Galactose metabolism_Homo sapiens_hsa000521.79467591
7Focal adhesion_Homo sapiens_hsa045101.74725391
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69208907
9Biosynthesis of amino acids_Homo sapiens_hsa012301.66442925
10Fat digestion and absorption_Homo sapiens_hsa049751.60880220
11Protein digestion and absorption_Homo sapiens_hsa049741.56873383
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53057523
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.51841614
14Fatty acid degradation_Homo sapiens_hsa000711.49597826
15Thyroid cancer_Homo sapiens_hsa052161.48635552
16Amoebiasis_Homo sapiens_hsa051461.47951942
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46955854
18Non-small cell lung cancer_Homo sapiens_hsa052231.46628075
19PPAR signaling pathway_Homo sapiens_hsa033201.35640513
20Bladder cancer_Homo sapiens_hsa052191.34653146
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33249117
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30768173
23Proteoglycans in cancer_Homo sapiens_hsa052051.30633419
24Sulfur relay system_Homo sapiens_hsa041221.29132300
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.25704912
26Fatty acid metabolism_Homo sapiens_hsa012121.24655813
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24498170
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.24132118
29Mineral absorption_Homo sapiens_hsa049781.23672753
30Small cell lung cancer_Homo sapiens_hsa052221.22361415
31Histidine metabolism_Homo sapiens_hsa003401.21026144
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18745624
33Lysosome_Homo sapiens_hsa041421.18581271
34Chronic myeloid leukemia_Homo sapiens_hsa052201.17947456
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17558111
36Insulin signaling pathway_Homo sapiens_hsa049101.16484662
37Lysine degradation_Homo sapiens_hsa003101.15986324
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12603211
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11834642
40N-Glycan biosynthesis_Homo sapiens_hsa005101.09251416
41* Bile secretion_Homo sapiens_hsa049761.08817711
42Adherens junction_Homo sapiens_hsa045201.08578026
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08558868
44Steroid biosynthesis_Homo sapiens_hsa001001.08341028
45Vibrio cholerae infection_Homo sapiens_hsa051101.07605888
46Carbon metabolism_Homo sapiens_hsa012001.07151298
47Complement and coagulation cascades_Homo sapiens_hsa046101.06782272
48mTOR signaling pathway_Homo sapiens_hsa041501.05166695
49Glioma_Homo sapiens_hsa052141.04494362
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02605056
51Tryptophan metabolism_Homo sapiens_hsa003801.01853293
52Tight junction_Homo sapiens_hsa045301.01450798
53AMPK signaling pathway_Homo sapiens_hsa041521.00624755
54Toxoplasmosis_Homo sapiens_hsa051451.00542582
55ABC transporters_Homo sapiens_hsa020100.98963158
56Staphylococcus aureus infection_Homo sapiens_hsa051500.98391147
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98209210
58Vitamin digestion and absorption_Homo sapiens_hsa049770.95417033
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94905500
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93211385
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.91927068
62ErbB signaling pathway_Homo sapiens_hsa040120.90976323
63Fatty acid elongation_Homo sapiens_hsa000620.90667063
64Vitamin B6 metabolism_Homo sapiens_hsa007500.90442722
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90395222
66Insulin resistance_Homo sapiens_hsa049310.88842080
67Caffeine metabolism_Homo sapiens_hsa002320.87978631
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86942793
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86255232
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86237497
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85073886
72Chemical carcinogenesis_Homo sapiens_hsa052040.83936525
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.83912702
74Arginine biosynthesis_Homo sapiens_hsa002200.83711291
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.83406540
76Notch signaling pathway_Homo sapiens_hsa043300.83399493
77Malaria_Homo sapiens_hsa051440.82724696
78Butanoate metabolism_Homo sapiens_hsa006500.81637877
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80844592
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78175203
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78041459
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77695098
83Hepatitis B_Homo sapiens_hsa051610.76688971
84Starch and sucrose metabolism_Homo sapiens_hsa005000.76277602
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74019372
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73773391
87Pancreatic cancer_Homo sapiens_hsa052120.71596984
88DNA replication_Homo sapiens_hsa030300.71182168
89Dilated cardiomyopathy_Homo sapiens_hsa054140.69553850
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69383420
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69173462
92Osteoclast differentiation_Homo sapiens_hsa043800.65989060
93Estrogen signaling pathway_Homo sapiens_hsa049150.65785719
94Prostate cancer_Homo sapiens_hsa052150.65460184
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65303178
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65126237
97MicroRNAs in cancer_Homo sapiens_hsa052060.64950953
98Melanoma_Homo sapiens_hsa052180.64803104
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64712130
100Viral carcinogenesis_Homo sapiens_hsa052030.64155939
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63038767
102HTLV-I infection_Homo sapiens_hsa051660.61626440
103Other glycan degradation_Homo sapiens_hsa005110.61486164
104Glycerolipid metabolism_Homo sapiens_hsa005610.60138927
105Endometrial cancer_Homo sapiens_hsa052130.59976462
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.59593979
107Renal cell carcinoma_Homo sapiens_hsa052110.59461618
108HIF-1 signaling pathway_Homo sapiens_hsa040660.59213381
109Pathways in cancer_Homo sapiens_hsa052000.58940416
110GnRH signaling pathway_Homo sapiens_hsa049120.57796833
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57661243
112Prolactin signaling pathway_Homo sapiens_hsa049170.57403218
113Prion diseases_Homo sapiens_hsa050200.56752758
114Hippo signaling pathway_Homo sapiens_hsa043900.56554737
115Colorectal cancer_Homo sapiens_hsa052100.56372274
116Platelet activation_Homo sapiens_hsa046110.56316110
117Salmonella infection_Homo sapiens_hsa051320.56178059
118Inositol phosphate metabolism_Homo sapiens_hsa005620.55481309
119Shigellosis_Homo sapiens_hsa051310.55366217
120TNF signaling pathway_Homo sapiens_hsa046680.55362513
121Arginine and proline metabolism_Homo sapiens_hsa003300.55055637
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54560203
123Fatty acid biosynthesis_Homo sapiens_hsa000610.54506451
124Sphingolipid metabolism_Homo sapiens_hsa006000.54346639
125Leishmaniasis_Homo sapiens_hsa051400.53548662
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53484525
127Viral myocarditis_Homo sapiens_hsa054160.53370975
128Apoptosis_Homo sapiens_hsa042100.53210811
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53085737
130VEGF signaling pathway_Homo sapiens_hsa043700.52789151
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52350469
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.51562337
133Phenylalanine metabolism_Homo sapiens_hsa003600.51555774
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51415428
135Dorso-ventral axis formation_Homo sapiens_hsa043200.51139724
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.50457379
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50353527
138Endocytosis_Homo sapiens_hsa041440.50338360
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.50268740
140Propanoate metabolism_Homo sapiens_hsa006400.50261053
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50168975
142Peroxisome_Homo sapiens_hsa041460.50085441
143Acute myeloid leukemia_Homo sapiens_hsa052210.49758951
144Choline metabolism in cancer_Homo sapiens_hsa052310.49731210
145Hepatitis C_Homo sapiens_hsa051600.49713744
146Cell cycle_Homo sapiens_hsa041100.48212559
147beta-Alanine metabolism_Homo sapiens_hsa004100.47996119
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47637621
149TGF-beta signaling pathway_Homo sapiens_hsa043500.47501451
150B cell receptor signaling pathway_Homo sapiens_hsa046620.46576433
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42709575

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