SLC4A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.25381404
2synaptic vesicle maturation (GO:0016188)6.07591911
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.90077713
4locomotory exploration behavior (GO:0035641)5.84735738
5synaptic vesicle exocytosis (GO:0016079)5.39368394
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.37862933
7vocalization behavior (GO:0071625)5.21245568
8glutamate secretion (GO:0014047)5.16015972
9regulation of synaptic vesicle exocytosis (GO:2000300)5.01315185
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.93442945
11pyrimidine nucleobase catabolic process (GO:0006208)4.84457349
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.71374988
13protein localization to synapse (GO:0035418)4.69405204
14regulation of glutamate receptor signaling pathway (GO:1900449)4.67914519
15exploration behavior (GO:0035640)4.59902391
16neuron cell-cell adhesion (GO:0007158)4.57524175
17behavioral response to nicotine (GO:0035095)4.51509234
18layer formation in cerebral cortex (GO:0021819)4.50095775
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.49642657
20regulation of synaptic vesicle transport (GO:1902803)4.45790996
21neurotransmitter secretion (GO:0007269)4.41016909
22presynaptic membrane assembly (GO:0097105)4.19985690
23regulation of neuronal synaptic plasticity (GO:0048168)4.18629354
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16265478
25proline transport (GO:0015824)4.11961689
26nucleobase catabolic process (GO:0046113)4.03873375
27presynaptic membrane organization (GO:0097090)4.02243484
28synaptic transmission, glutamatergic (GO:0035249)4.02120370
29gamma-aminobutyric acid transport (GO:0015812)4.01521100
30glutamate receptor signaling pathway (GO:0007215)4.00192928
31neuronal action potential propagation (GO:0019227)3.98897675
32dendritic spine morphogenesis (GO:0060997)3.98573743
33regulation of synapse structural plasticity (GO:0051823)3.94845551
34regulation of vesicle fusion (GO:0031338)3.92514425
35cellular potassium ion homeostasis (GO:0030007)3.91620122
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85185551
37sodium ion export (GO:0071436)3.85141164
38activation of protein kinase A activity (GO:0034199)3.81000778
39neuron-neuron synaptic transmission (GO:0007270)3.78394802
40neuron recognition (GO:0008038)3.75748189
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73422652
42long-term memory (GO:0007616)3.71428400
43neurotransmitter transport (GO:0006836)3.64166678
44synaptic vesicle endocytosis (GO:0048488)3.62524159
45positive regulation of membrane potential (GO:0045838)3.60801869
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.57503087
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.57201708
48cerebellar Purkinje cell differentiation (GO:0021702)3.55199082
49neurotransmitter-gated ion channel clustering (GO:0072578)3.52663036
50dendrite morphogenesis (GO:0048813)3.50724014
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50381321
52regulation of postsynaptic membrane potential (GO:0060078)3.46417707
53axonal fasciculation (GO:0007413)3.46254240
54central nervous system projection neuron axonogenesis (GO:0021952)3.43480777
55transmission of nerve impulse (GO:0019226)3.39424286
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.38339992
57regulation of neurotransmitter secretion (GO:0046928)3.35390602
58regulation of synaptic plasticity (GO:0048167)3.35091053
59startle response (GO:0001964)3.33958425
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.33797340
61neuromuscular process controlling balance (GO:0050885)3.30081261
62regulation of neurotransmitter levels (GO:0001505)3.29975662
63positive regulation of synapse maturation (GO:0090129)3.29560005
64glycine transport (GO:0015816)3.28321104
65regulation of ARF protein signal transduction (GO:0032012)3.27385825
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26155585
67neuromuscular process controlling posture (GO:0050884)3.25600050
68cilium or flagellum-dependent cell motility (GO:0001539)3.25164196
69innervation (GO:0060384)3.23541896
70auditory behavior (GO:0031223)3.21859399
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19337455
72regulation of dendritic spine morphogenesis (GO:0061001)3.19290117
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17394056
74cilium movement (GO:0003341)3.16524075
75long-term synaptic potentiation (GO:0060291)3.15057212
76vesicle transport along microtubule (GO:0047496)3.14649518
77protein localization to cilium (GO:0061512)3.13701234
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.13342019
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13134340
80response to auditory stimulus (GO:0010996)3.12993082
81negative regulation of cytosolic calcium ion concentration (GO:0051481)3.11020858
82membrane hyperpolarization (GO:0060081)3.10620187
83epithelial cilium movement (GO:0003351)3.10434010
84postsynaptic membrane organization (GO:0001941)3.10156667
85central nervous system neuron axonogenesis (GO:0021955)3.09925244
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09690375
87cell communication by electrical coupling (GO:0010644)3.08691385
88regulation of neurotransmitter transport (GO:0051588)3.08188964
89cell migration in hindbrain (GO:0021535)3.08044324
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07931464
91neuromuscular synaptic transmission (GO:0007274)3.07414060
92prepulse inhibition (GO:0060134)3.06436985
93membrane depolarization during action potential (GO:0086010)3.06332968
94central nervous system myelination (GO:0022010)3.05991383
95axon ensheathment in central nervous system (GO:0032291)3.05991383
96negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04837307
97membrane depolarization (GO:0051899)3.04476222
98neuronal action potential (GO:0019228)3.02786548
99nonmotile primary cilium assembly (GO:0035058)3.00753492
100regulation of calcium ion-dependent exocytosis (GO:0017158)3.00172496
101synapse assembly (GO:0007416)2.99738115
102axonemal dynein complex assembly (GO:0070286)2.97682876
103intraspecies interaction between organisms (GO:0051703)2.95426739
104social behavior (GO:0035176)2.95426739
105organelle transport along microtubule (GO:0072384)2.94910323
106positive regulation of neurotransmitter transport (GO:0051590)2.94469075
107positive regulation of neurotransmitter secretion (GO:0001956)2.93528445
108neuronal ion channel clustering (GO:0045161)2.92899064
109regulation of clathrin-mediated endocytosis (GO:2000369)2.92573997
110mating behavior (GO:0007617)2.92232360
111learning (GO:0007612)2.90128571
112response to histamine (GO:0034776)2.89461887
113behavioral fear response (GO:0001662)2.89013905
114behavioral defense response (GO:0002209)2.89013905
115synaptic transmission (GO:0007268)2.88340754
116retinal ganglion cell axon guidance (GO:0031290)2.88149620
117L-amino acid import (GO:0043092)2.87015105
118mechanosensory behavior (GO:0007638)2.86991728
119adult walking behavior (GO:0007628)2.85745573
120cochlea development (GO:0090102)2.85607771
121neuromuscular process (GO:0050905)2.83561952
122regulation of synaptic transmission (GO:0050804)2.83424137
123chemosensory behavior (GO:0007635)2.83290437
124retinal cone cell development (GO:0046549)2.82609605
125protein polyglutamylation (GO:0018095)2.82164693
126establishment of mitochondrion localization (GO:0051654)2.80918659
127regulation of respiratory system process (GO:0044065)2.80641160
128positive regulation of dendritic spine morphogenesis (GO:0061003)2.80469819
129serotonin metabolic process (GO:0042428)2.74525811
130axoneme assembly (GO:0035082)2.74435834
131primary amino compound metabolic process (GO:1901160)2.71877380
132glycosphingolipid biosynthetic process (GO:0006688)2.65822163
133cerebral cortex radially oriented cell migration (GO:0021799)2.64833933
134regulation of cilium movement (GO:0003352)2.62464226
135regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.61123420
136adult behavior (GO:0030534)2.61044813
137retina layer formation (GO:0010842)2.59368711
138spinal cord development (GO:0021510)2.59044418
139cilium organization (GO:0044782)2.58490983
140regulation of microtubule-based movement (GO:0060632)2.58167574
141positive regulation of synapse assembly (GO:0051965)2.57523675
142cilium assembly (GO:0042384)2.56852060
143synapse organization (GO:0050808)2.56541492
144behavioral response to ethanol (GO:0048149)2.55921041
145synaptic transmission, cholinergic (GO:0007271)2.53029132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76098831
2GBX2_23144817_ChIP-Seq_PC3_Human3.10059708
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87506983
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86451145
5REST_21632747_ChIP-Seq_MESCs_Mouse2.72384995
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69896280
7DROSHA_22980978_ChIP-Seq_HELA_Human2.62428704
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47475316
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47475316
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.44986436
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44467285
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40600210
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37618689
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33543404
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.26847249
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24578150
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22018897
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18188111
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17868430
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.17361044
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.14631899
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.14607528
23VDR_22108803_ChIP-Seq_LS180_Human2.14511891
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06792885
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00132421
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98295329
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93544262
28AR_21572438_ChIP-Seq_LNCaP_Human1.91743568
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.86227418
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84193166
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78084133
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.75007132
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72596007
34FUS_26573619_Chip-Seq_HEK293_Human1.68874459
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68135033
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68007926
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63966816
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62523171
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.58184709
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53559044
41IGF1R_20145208_ChIP-Seq_DFB_Human1.50510428
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48786725
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45045191
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44013919
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42916886
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38661567
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.33499594
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33427135
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.33086039
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.31796378
51EWS_26573619_Chip-Seq_HEK293_Human1.29865579
52TAF15_26573619_Chip-Seq_HEK293_Human1.29751036
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28373548
54* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28118018
55* ER_23166858_ChIP-Seq_MCF-7_Human1.28078000
56KDM2B_26808549_Chip-Seq_K562_Human1.27427936
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25992932
58ZNF274_21170338_ChIP-Seq_K562_Hela1.25965947
59STAT3_23295773_ChIP-Seq_U87_Human1.25825226
60BCAT_22108803_ChIP-Seq_LS180_Human1.24836396
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24641700
62CBP_20019798_ChIP-Seq_JUKART_Human1.24641700
63AR_19668381_ChIP-Seq_PC3_Human1.24217286
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23314318
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.22227797
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22218278
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21900957
68P300_19829295_ChIP-Seq_ESCs_Human1.21664918
69AR_25329375_ChIP-Seq_VCAP_Human1.18685044
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.18089893
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.17836153
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14993843
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14369443
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12487421
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11171034
76TCF4_23295773_ChIP-Seq_U87_Human1.11093381
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10966394
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10876768
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.10815457
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.10462097
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10283863
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09182399
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09110324
84AHR_22903824_ChIP-Seq_MCF-7_Human1.08399710
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07686214
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07651081
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05638982
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05527740
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05486258
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05195255
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05090893
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.04395692
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.04341347
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04205730
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.03992494
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03878249
97* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02346603
98* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02346603
99RNF2_27304074_Chip-Seq_NSC_Mouse1.02230367
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.02102387
101SMAD3_21741376_ChIP-Seq_ESCs_Human1.02097003
102IRF1_19129219_ChIP-ChIP_H3396_Human1.01806988
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01711793
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01219722
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00980173
106TCF4_22108803_ChIP-Seq_LS180_Human1.00369991
107* SMAD4_21741376_ChIP-Seq_EPCs_Human1.00243564
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99723796
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99283267
110TAL1_26923725_Chip-Seq_HPCs_Mouse0.99280890
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98373767
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.97687956
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97155486
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96813411
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.96649266
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96566557
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.94070689
118RUNX2_22187159_ChIP-Seq_PCA_Human0.92049846
119TP53_16413492_ChIP-PET_HCT116_Human0.92031642
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91622515
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90060527
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89517715
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88478367
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87343472
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86918998
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86397832
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86243493
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85551457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.49458537
2MP0003880_abnormal_central_pattern4.56515998
3MP0003635_abnormal_synaptic_transmissio4.08906378
4MP0004270_analgesia3.85557905
5MP0009046_muscle_twitch3.29266527
6MP0005423_abnormal_somatic_nervous3.26772590
7MP0009745_abnormal_behavioral_response3.25168951
8MP0002063_abnormal_learning/memory/cond3.23049281
9MP0002064_seizures3.04382956
10MP0002734_abnormal_mechanical_nocicepti2.70274738
11MP0001968_abnormal_touch/_nociception2.69455787
12MP0002572_abnormal_emotion/affect_behav2.67065629
13MP0001486_abnormal_startle_reflex2.52714010
14MP0002272_abnormal_nervous_system2.46131958
15MP0001501_abnormal_sleep_pattern2.27407704
16MP0000778_abnormal_nervous_system2.05350016
17MP0002733_abnormal_thermal_nociception2.04436417
18MP0001440_abnormal_grooming_behavior2.03957764
19MP0004858_abnormal_nervous_system2.01286496
20MP0002735_abnormal_chemical_nociception1.97587593
21MP0002184_abnormal_innervation1.97173923
22MP0005645_abnormal_hypothalamus_physiol1.93836553
23MP0008569_lethality_at_weaning1.93138485
24MP0001970_abnormal_pain_threshold1.92546822
25MP0009780_abnormal_chondrocyte_physiolo1.89611289
26MP0003787_abnormal_imprinting1.89007122
27MP0002067_abnormal_sensory_capabilities1.87363926
28MP0002822_catalepsy1.85118515
29MP0000569_abnormal_digit_pigmentation1.84976657
30MP0003329_amyloid_beta_deposits1.82527349
31MP0002736_abnormal_nociception_after1.82130614
32MP0004811_abnormal_neuron_physiology1.78144033
33MP0001984_abnormal_olfaction1.74229954
34MP0002557_abnormal_social/conspecific_i1.72516430
35MP0004924_abnormal_behavior1.69543776
36MP0005386_behavior/neurological_phenoty1.69543776
37MP0004885_abnormal_endolymph1.62131015
38MP0005646_abnormal_pituitary_gland1.60614959
39MP0000955_abnormal_spinal_cord1.59597632
40MP0002909_abnormal_adrenal_gland1.56921744
41MP0006292_abnormal_olfactory_placode1.54802286
42MP0003879_abnormal_hair_cell1.54605626
43MP0003121_genomic_imprinting1.54428399
44MP0002882_abnormal_neuron_morphology1.53515726
45MP0006276_abnormal_autonomic_nervous1.51181108
46MP0001348_abnormal_lacrimal_gland1.50550242
47MP0004133_heterotaxia1.48574532
48MP0001502_abnormal_circadian_rhythm1.44617412
49MP0002066_abnormal_motor_capabilities/c1.42546451
50MP0004510_myositis1.36277882
51MP0002254_reproductive_system_inflammat1.34632043
52MP0005551_abnormal_eye_electrophysiolog1.34222088
53MP0003633_abnormal_nervous_system1.25313397
54MP0002152_abnormal_brain_morphology1.18389308
55MP0004142_abnormal_muscle_tone1.13605022
56MP0003195_calcinosis1.12285874
57MP0002229_neurodegeneration1.09825622
58MP0003631_nervous_system_phenotype1.08426781
59MP0004043_abnormal_pH_regulation1.05354449
60MP0005499_abnormal_olfactory_system1.04269847
61MP0005394_taste/olfaction_phenotype1.04269847
62MP0002751_abnormal_autonomic_nervous1.03471267
63MP0003122_maternal_imprinting1.02863677
64MP0001905_abnormal_dopamine_level1.02613339
65MP0002837_dystrophic_cardiac_calcinosis0.98400132
66MP0003119_abnormal_digestive_system0.97955565
67MP0008961_abnormal_basal_metabolism0.97490130
68MP0001529_abnormal_vocalization0.96886733
69MP0000026_abnormal_inner_ear0.94610222
70MP0001986_abnormal_taste_sensitivity0.94157771
71MP0005195_abnormal_posterior_eye0.93938591
72MP0000604_amyloidosis0.93895187
73MP0003890_abnormal_embryonic-extraembry0.92689901
74MP0004742_abnormal_vestibular_system0.91648434
75MP0003634_abnormal_glial_cell0.91098120
76MP0002069_abnormal_eating/drinking_beha0.89979244
77MP0000427_abnormal_hair_cycle0.86754025
78MP0003938_abnormal_ear_development0.86463504
79MP0002752_abnormal_somatic_nervous0.86316178
80MP0008874_decreased_physiological_sensi0.86181070
81MP0000566_synostosis0.85798247
82MP0003283_abnormal_digestive_organ0.85548578
83MP0003172_abnormal_lysosome_physiology0.85185828
84MP0006072_abnormal_retinal_apoptosis0.85053665
85MP0010386_abnormal_urinary_bladder0.84096894
86* MP0008872_abnormal_physiological_respon0.82513207
87MP0003136_yellow_coat_color0.82451330
88MP0003632_abnormal_nervous_system0.81344684
89MP0004145_abnormal_muscle_electrophysio0.80694880
90MP0002928_abnormal_bile_duct0.80257128
91MP0002938_white_spotting0.79963808
92MP0008789_abnormal_olfactory_epithelium0.79793136
93MP0003698_abnormal_male_reproductive0.79242676
94MP0000631_abnormal_neuroendocrine_gland0.78297342
95MP0004147_increased_porphyrin_level0.77472770
96MP0001963_abnormal_hearing_physiology0.77396561
97MP0001485_abnormal_pinna_reflex0.77139656
98MP0000383_abnormal_hair_follicle0.75741384
99MP0002638_abnormal_pupillary_reflex0.75354304
100MP0005623_abnormal_meninges_morphology0.75082764
101MP0002090_abnormal_vision0.74017552
102MP0001177_atelectasis0.73841154
103MP0004233_abnormal_muscle_weight0.71182187
104MP0003123_paternal_imprinting0.70622706
105MP0005310_abnormal_salivary_gland0.70301680
106MP0005535_abnormal_body_temperature0.69340879
107MP0000920_abnormal_myelination0.68352462
108MP0003937_abnormal_limbs/digits/tail_de0.68327492
109MP0002653_abnormal_ependyma_morphology0.68033815
110MP0005253_abnormal_eye_physiology0.67634299
111MP0000013_abnormal_adipose_tissue0.67528559
112MP0000751_myopathy0.66377027
113MP0005187_abnormal_penis_morphology0.66099629
114MP0008877_abnormal_DNA_methylation0.66014340
115MP0003861_abnormal_nervous_system0.65709059
116MP0003690_abnormal_glial_cell0.65493048
117MP0001188_hyperpigmentation0.65192676
118MP0001299_abnormal_eye_distance/0.61706509
119MP0004085_abnormal_heartbeat0.60184390
120MP0003075_altered_response_to0.58751162
121MP0002102_abnormal_ear_morphology0.55912691
122MP0010769_abnormal_survival0.55489163
123MP0003137_abnormal_impulse_conducting0.54188391
124MP0002876_abnormal_thyroid_physiology0.54125317

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.51644518
2Myokymia (HP:0002411)6.17785430
3Focal seizures (HP:0007359)5.30230671
4Visual hallucinations (HP:0002367)5.14110226
5Epileptic encephalopathy (HP:0200134)4.54610770
6Progressive cerebellar ataxia (HP:0002073)4.35804193
7Febrile seizures (HP:0002373)4.27885667
8Atonic seizures (HP:0010819)4.27494922
9Supranuclear gaze palsy (HP:0000605)4.13736343
10Absence seizures (HP:0002121)3.81059355
11Action tremor (HP:0002345)3.71585586
12Ankle clonus (HP:0011448)3.66688045
13Generalized tonic-clonic seizures (HP:0002069)3.44682634
14Papilledema (HP:0001085)3.44677841
15Dialeptic seizures (HP:0011146)3.41056912
16Urinary bladder sphincter dysfunction (HP:0002839)3.38102072
17Pancreatic fibrosis (HP:0100732)3.36616800
18Pancreatic cysts (HP:0001737)3.35438731
19Nephronophthisis (HP:0000090)3.32438435
20Molar tooth sign on MRI (HP:0002419)3.32191727
21Abnormality of midbrain morphology (HP:0002418)3.32191727
22Mutism (HP:0002300)3.27308166
23True hermaphroditism (HP:0010459)3.26926450
24Broad-based gait (HP:0002136)3.22636086
25Gaze-evoked nystagmus (HP:0000640)3.18147755
26Genetic anticipation (HP:0003743)3.13699232
27Truncal ataxia (HP:0002078)3.12324807
28Impaired vibration sensation in the lower limbs (HP:0002166)3.09633314
29Poor eye contact (HP:0000817)3.06066521
30Depression (HP:0000716)3.04916535
31Abnormal ciliary motility (HP:0012262)3.04016577
32Dysmetria (HP:0001310)3.02510374
33Abnormal respiratory epithelium morphology (HP:0012253)2.98803304
34Abnormal respiratory motile cilium morphology (HP:0005938)2.98803304
35Postural instability (HP:0002172)2.92808968
36Dysdiadochokinesis (HP:0002075)2.92498743
37Type II lissencephaly (HP:0007260)2.90555941
38Medial flaring of the eyebrow (HP:0010747)2.89859041
39Spastic gait (HP:0002064)2.85109360
40Neurofibrillary tangles (HP:0002185)2.83754617
41Urinary urgency (HP:0000012)2.83463812
42Impaired social interactions (HP:0000735)2.82491963
43Abnormal social behavior (HP:0012433)2.82491963
44Hemiplegia (HP:0002301)2.81963265
45Abnormality of the renal medulla (HP:0100957)2.77194123
46Abnormality of the corticospinal tract (HP:0002492)2.75746160
47Drooling (HP:0002307)2.74421746
48Excessive salivation (HP:0003781)2.74421746
49Abnormal respiratory motile cilium physiology (HP:0012261)2.74010381
50Lissencephaly (HP:0001339)2.73603074
51Hemiparesis (HP:0001269)2.70973617
52Impaired smooth pursuit (HP:0007772)2.70037649
53Cerebral inclusion bodies (HP:0100314)2.69401159
54Abnormality of the lower motor neuron (HP:0002366)2.69330235
55Abnormal eating behavior (HP:0100738)2.64168292
56Chronic hepatic failure (HP:0100626)2.59250238
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.55523320
58Amblyopia (HP:0000646)2.54633556
59Congenital primary aphakia (HP:0007707)2.54078876
60Insomnia (HP:0100785)2.51727515
61Abnormality of binocular vision (HP:0011514)2.51353593
62Diplopia (HP:0000651)2.51353593
63Anxiety (HP:0000739)2.50012453
64Congenital stationary night blindness (HP:0007642)2.49951788
65Intention tremor (HP:0002080)2.49226506
66Hyperventilation (HP:0002883)2.47504885
67Megalencephaly (HP:0001355)2.44773688
68Progressive inability to walk (HP:0002505)2.44754511
69Protruding tongue (HP:0010808)2.43732389
70Cystic liver disease (HP:0006706)2.43705257
71Amyotrophic lateral sclerosis (HP:0007354)2.42852717
72Abnormality of ocular smooth pursuit (HP:0000617)2.40990209
73Genital tract atresia (HP:0001827)2.40162033
74Lower limb muscle weakness (HP:0007340)2.38349626
75Bradykinesia (HP:0002067)2.37817094
76Nephrogenic diabetes insipidus (HP:0009806)2.36756410
77Epileptiform EEG discharges (HP:0011182)2.35299283
78Pachygyria (HP:0001302)2.33061801
79Vaginal atresia (HP:0000148)2.32880418
80EEG with generalized epileptiform discharges (HP:0011198)2.30593781
81Scanning speech (HP:0002168)2.28480906
82Optic nerve hypoplasia (HP:0000609)2.27852949
83Torticollis (HP:0000473)2.25831690
84Stereotypic behavior (HP:0000733)2.24455521
85Limb dystonia (HP:0002451)2.23663112
86Retinal dysplasia (HP:0007973)2.22919054
87Termporal pattern (HP:0011008)2.21924973
88Insidious onset (HP:0003587)2.21924973
89Pheochromocytoma (HP:0002666)2.21426464
90Absent speech (HP:0001344)2.19807209
91Hypsarrhythmia (HP:0002521)2.19351083
92Rhinitis (HP:0012384)2.17202182
93Pointed chin (HP:0000307)2.15492550
94Abnormality of the renal cortex (HP:0011035)2.14080891
95Inappropriate behavior (HP:0000719)2.11971976
96Abnormality of the labia minora (HP:0012880)2.11540770
97Cerebellar dysplasia (HP:0007033)2.10253390
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09542556
99Agitation (HP:0000713)2.09428532
100Dysmetric saccades (HP:0000641)2.08718261
101Clonus (HP:0002169)2.08367440
102Impaired vibratory sensation (HP:0002495)2.03505450
103Focal dystonia (HP:0004373)2.00231884
104Anencephaly (HP:0002323)1.99986803
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.99131573
106Absent/shortened dynein arms (HP:0200106)1.99131573
107Fetal akinesia sequence (HP:0001989)1.98702463
108Generalized myoclonic seizures (HP:0002123)1.96880876
109Ventricular fibrillation (HP:0001663)1.96566479
110Abnormal drinking behavior (HP:0030082)1.96522562
111Polydipsia (HP:0001959)1.96522562
112Degeneration of the lateral corticospinal tracts (HP:0002314)1.96337215
113Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96337215
114Abolished electroretinogram (ERG) (HP:0000550)1.95526520
115Polyphagia (HP:0002591)1.93942620
116Tubular atrophy (HP:0000092)1.93136281
117Sclerocornea (HP:0000647)1.92425351
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91197734
119Central scotoma (HP:0000603)1.90505381
120Gait imbalance (HP:0002141)1.90132687
121Intestinal atresia (HP:0011100)1.89694038
122Akinesia (HP:0002304)1.89162266
123Blue irides (HP:0000635)1.88377288
124Pendular nystagmus (HP:0012043)1.87342639
125Abnormality of salivation (HP:0100755)1.86835896
126Occipital encephalocele (HP:0002085)1.86263410
127Apathy (HP:0000741)1.85794702
128Abnormal rod and cone electroretinograms (HP:0008323)1.85534295
129Inability to walk (HP:0002540)1.84294544
130Poor coordination (HP:0002370)1.84246011
131Neuroendocrine neoplasm (HP:0100634)1.81939450
132Neuronal loss in central nervous system (HP:0002529)1.81626940
133Status epilepticus (HP:0002133)1.80679811
134Postaxial hand polydactyly (HP:0001162)1.80207653
135Specific learning disability (HP:0001328)1.79741491
136Hyperacusis (HP:0010780)1.79349139
137Abnormality of saccadic eye movements (HP:0000570)1.78528179
138Postaxial foot polydactyly (HP:0001830)1.78478826
139Abnormality of macular pigmentation (HP:0008002)1.77248477
140Bony spicule pigmentary retinopathy (HP:0007737)1.76827140
141Narrow forehead (HP:0000341)1.76214255
142Craniofacial dystonia (HP:0012179)1.75735948
143Aqueductal stenosis (HP:0002410)1.75351268
144Elfin facies (HP:0004428)1.74025187
145Spastic tetraplegia (HP:0002510)1.73055546
146Macroorchidism (HP:0000053)1.73041970
147Morphological abnormality of the pyramidal tract (HP:0002062)1.72887726
148Gait ataxia (HP:0002066)1.72804911
149Tubulointerstitial nephritis (HP:0001970)1.72773591
150Hypoplasia of the brainstem (HP:0002365)1.72159015
151Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72159015
152Lower limb amyotrophy (HP:0007210)1.72003992
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.71093896
154Congenital hepatic fibrosis (HP:0002612)1.68181382
155Attenuation of retinal blood vessels (HP:0007843)1.68176477
156Failure to thrive in infancy (HP:0001531)1.67282383
157Hypothermia (HP:0002045)1.64223858
158Oligodactyly (hands) (HP:0001180)1.62748658
159Cutaneous finger syndactyly (HP:0010554)1.61939082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.51978987
2NTRK34.27408835
3MARK14.07715584
4FRK3.47970167
5EPHA43.19096902
6MAP3K43.03953683
7PAK62.68491075
8MINK12.60746355
9NTRK22.53073148
10MAP2K72.37780053
11DAPK22.12233311
12PRKD32.12145057
13KSR22.02734043
14NTRK11.93799689
15MAP3K131.87637549
16MAP2K41.70149812
17DYRK21.67043042
18CAMKK11.65619385
19ZAK1.64966501
20BMPR1B1.64664506
21CDK51.58830487
22ADRBK21.57032221
23MAPK131.49088577
24MAP4K21.47887861
25RIPK41.46847954
26KSR11.45028985
27TLK11.43710728
28MAP3K121.43432943
29TYRO31.37455212
30SIK21.36669464
31TNIK1.36335373
32STK381.35860335
33PNCK1.34340806
34INSRR1.32087388
35GRK51.30897748
36PHKG21.26878677
37PHKG11.26878677
38PLK21.22336332
39BCR1.19443727
40ACVR1B1.19393032
41DAPK11.18757236
42LATS21.15765716
43STK111.14092032
44UHMK11.13831854
45CDK191.13137977
46CASK1.12682934
47GRK11.12163332
48WNK41.11453672
49RET1.10900789
50PRPF4B1.08769482
51MAP3K21.06030483
52PAK31.04337954
53PRKCG1.04021780
54ARAF1.02630643
55FES0.94196643
56FGFR20.93994118
57TRIM280.89427953
58TAOK10.89097699
59CAMK2A0.88585963
60SGK2230.88561016
61SGK4940.88561016
62PKN10.88383209
63MAPK150.87687735
64SGK10.86749791
65ALK0.86262302
66CDK150.84748454
67CDK180.83840560
68DYRK1A0.82358335
69MKNK20.80216967
70STK390.78217007
71CDK140.77953443
72MARK20.75498453
73CSNK1G20.75271072
74CDK11A0.72588414
75RAF10.72350299
76CAMKK20.71800538
77SGK20.71788461
78SCYL20.70937878
79CDC42BPA0.70601249
80PRKCZ0.70575055
81WNK10.70547611
82CAMK10.68683745
83PRKCH0.68645664
84SGK30.67993936
85CSNK1G10.67494726
86BMPR20.67279829
87CSNK1G30.66103357
88CAMK1G0.66016414
89NUAK10.65948960
90CAMK2B0.64848954
91ICK0.60698745
92LMTK20.59679603
93RIPK10.57540988
94MAP3K70.56945791
95CSNK1A1L0.55649461
96MAP3K60.55126581
97OXSR10.54178492
98ERBB20.54012942
99AKT30.53997117
100PDK10.53693312
101RPS6KA30.53028354
102MAPK100.51863190
103PRKCE0.47390056
104ADRBK10.47272157
105FYN0.46365415
106PTK2B0.46157401
107FGR0.45343873
108PRKG10.45306168
109PRKACA0.44740689
110PDPK10.44329154
111MAP3K10.43591450
112TNK20.43476790
113PLK40.42765888
114STK160.42578414
115WNK30.42482145
116EPHB20.41955267
117CCNB10.39807916
118CSNK1D0.38181877
119RPS6KA20.38081914
120PRKCB0.37117617
121CSNK1A10.36244640
122CAMK2G0.34869807
123CAMK2D0.34337986
124ROCK20.34034529
125EPHA30.33931187
126STK38L0.33895923
127VRK10.33429366
128NEK60.33398162
129MAP2K60.33179415
130PRKAA10.33127293
131PINK10.32862300
132MAPK80.32351584
133PRKCA0.31222361
134CAMK40.30028284
135CSNK1E0.29920390
136GSK3B0.29520250
137PRKAA20.28810591
138ERBB30.27782144

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41971468
2Synaptic vesicle cycle_Homo sapiens_hsa047213.03388477
3Olfactory transduction_Homo sapiens_hsa047402.78089121
4GABAergic synapse_Homo sapiens_hsa047272.65718978
5Circadian entrainment_Homo sapiens_hsa047132.56413695
6Glutamatergic synapse_Homo sapiens_hsa047242.53505455
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49216158
8Morphine addiction_Homo sapiens_hsa050322.43611217
9Long-term potentiation_Homo sapiens_hsa047202.36038361
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24300093
11Amphetamine addiction_Homo sapiens_hsa050312.16047966
12Salivary secretion_Homo sapiens_hsa049702.06067057
13Dopaminergic synapse_Homo sapiens_hsa047282.01242083
14Insulin secretion_Homo sapiens_hsa049111.96736580
15Cholinergic synapse_Homo sapiens_hsa047251.89473058
16Gastric acid secretion_Homo sapiens_hsa049711.83889205
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.80601458
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72892335
19Butanoate metabolism_Homo sapiens_hsa006501.71911163
20Taste transduction_Homo sapiens_hsa047421.68823440
21Renin secretion_Homo sapiens_hsa049241.65781083
22Serotonergic synapse_Homo sapiens_hsa047261.64067665
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61331259
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60943789
25Oxytocin signaling pathway_Homo sapiens_hsa049211.59737223
26Long-term depression_Homo sapiens_hsa047301.58277358
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55386686
28Cocaine addiction_Homo sapiens_hsa050301.50861372
29GnRH signaling pathway_Homo sapiens_hsa049121.49852626
30Type II diabetes mellitus_Homo sapiens_hsa049301.37688077
31Phototransduction_Homo sapiens_hsa047441.35283527
32Calcium signaling pathway_Homo sapiens_hsa040201.34604753
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33164251
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32758140
35Gap junction_Homo sapiens_hsa045401.28428752
36cAMP signaling pathway_Homo sapiens_hsa040241.26825967
37Estrogen signaling pathway_Homo sapiens_hsa049151.25186265
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24151178
39Axon guidance_Homo sapiens_hsa043601.17451511
40ErbB signaling pathway_Homo sapiens_hsa040121.12416784
41Linoleic acid metabolism_Homo sapiens_hsa005911.11558536
42Glioma_Homo sapiens_hsa052141.09458748
43Dorso-ventral axis formation_Homo sapiens_hsa043201.08804923
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07817689
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05741659
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02241339
47Ether lipid metabolism_Homo sapiens_hsa005651.01785985
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00413022
49Melanogenesis_Homo sapiens_hsa049161.00301912
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98834587
51Collecting duct acid secretion_Homo sapiens_hsa049660.95059461
52Regulation of autophagy_Homo sapiens_hsa041400.94718676
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.92627073
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90347068
55MAPK signaling pathway_Homo sapiens_hsa040100.88910943
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.87920652
57Oxidative phosphorylation_Homo sapiens_hsa001900.87292748
58Oocyte meiosis_Homo sapiens_hsa041140.87175227
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87032999
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86736110
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84195626
62Pancreatic secretion_Homo sapiens_hsa049720.82119432
63Choline metabolism in cancer_Homo sapiens_hsa052310.81796452
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80348667
65ABC transporters_Homo sapiens_hsa020100.78939947
66Thyroid hormone synthesis_Homo sapiens_hsa049180.77494315
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.76890618
68Dilated cardiomyopathy_Homo sapiens_hsa054140.75144197
69Cardiac muscle contraction_Homo sapiens_hsa042600.75089981
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74762016
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74232922
72VEGF signaling pathway_Homo sapiens_hsa043700.73620116
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71865542
74mTOR signaling pathway_Homo sapiens_hsa041500.70426098
75Nitrogen metabolism_Homo sapiens_hsa009100.69225259
76Ras signaling pathway_Homo sapiens_hsa040140.67475581
77Vibrio cholerae infection_Homo sapiens_hsa051100.67143234
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66359871
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65723122
80Tryptophan metabolism_Homo sapiens_hsa003800.65371720
81Alzheimers disease_Homo sapiens_hsa050100.65279473
82Hedgehog signaling pathway_Homo sapiens_hsa043400.64499170
83Caffeine metabolism_Homo sapiens_hsa002320.63190170
84Ovarian steroidogenesis_Homo sapiens_hsa049130.62883184
85Type I diabetes mellitus_Homo sapiens_hsa049400.61992297
86Huntingtons disease_Homo sapiens_hsa050160.60742575
87Inositol phosphate metabolism_Homo sapiens_hsa005620.60606793
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60136392
89Chemokine signaling pathway_Homo sapiens_hsa040620.59723481
90Endometrial cancer_Homo sapiens_hsa052130.59079166
91Parkinsons disease_Homo sapiens_hsa050120.58288578
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.58218247
93Renal cell carcinoma_Homo sapiens_hsa052110.57418530
94Endocytosis_Homo sapiens_hsa041440.57309108
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57261982
96Hippo signaling pathway_Homo sapiens_hsa043900.56038568
97beta-Alanine metabolism_Homo sapiens_hsa004100.54947677
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54433713
99Circadian rhythm_Homo sapiens_hsa047100.54261549
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53924973
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53491862
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52993039
103Alcoholism_Homo sapiens_hsa050340.52728374
104Histidine metabolism_Homo sapiens_hsa003400.51840641
105Steroid biosynthesis_Homo sapiens_hsa001000.51464905
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51349329
107Selenocompound metabolism_Homo sapiens_hsa004500.51276968
108Glucagon signaling pathway_Homo sapiens_hsa049220.51004981
109Basal transcription factors_Homo sapiens_hsa030220.50942081
110Rap1 signaling pathway_Homo sapiens_hsa040150.50811612
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50420225
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49585031
113Non-small cell lung cancer_Homo sapiens_hsa052230.49137454
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48130874
115Prolactin signaling pathway_Homo sapiens_hsa049170.46679634
116Insulin signaling pathway_Homo sapiens_hsa049100.45206119
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44931186
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44668493
119Colorectal cancer_Homo sapiens_hsa052100.44579593
120Bile secretion_Homo sapiens_hsa049760.44011238
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43770992
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41621490
123Wnt signaling pathway_Homo sapiens_hsa043100.41457756
124Protein export_Homo sapiens_hsa030600.39616588
125Peroxisome_Homo sapiens_hsa041460.39101732
126Fatty acid biosynthesis_Homo sapiens_hsa000610.37780254
127Basal cell carcinoma_Homo sapiens_hsa052170.37374167
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.36286073
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36000221
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34885518
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32630950
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27887103
133T cell receptor signaling pathway_Homo sapiens_hsa046600.27703181
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.27691629

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