SLC4A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.88427127
2male meiosis (GO:0007140)9.86582824
3cell wall macromolecule metabolic process (GO:0044036)9.14757480
4DNA synthesis involved in DNA repair (GO:0000731)8.81242903
5meiotic nuclear division (GO:0007126)8.80720812
6DNA methylation involved in gamete generation (GO:0043046)8.62114642
7urate metabolic process (GO:0046415)8.49593319
8drug transmembrane transport (GO:0006855)8.32067325
9lysine catabolic process (GO:0006554)7.86988008
10lysine metabolic process (GO:0006553)7.86988008
11aminoglycoside antibiotic metabolic process (GO:0030647)7.49219852
12histone H3-K36 demethylation (GO:0070544)7.36875555
13meiotic chromosome segregation (GO:0045132)7.36646309
14positive regulation of chemokine secretion (GO:0090197)7.19784737
15glyoxylate metabolic process (GO:0046487)7.07875360
16signal complex assembly (GO:0007172)7.02211513
17drug transport (GO:0015893)6.98928057
18cysteine metabolic process (GO:0006534)6.66294413
19L-phenylalanine catabolic process (GO:0006559)6.57380228
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.57380228
21L-phenylalanine metabolic process (GO:0006558)6.46807485
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.46807485
23meiotic cell cycle process (GO:1903046)6.42640711
24phosphate ion transport (GO:0006817)6.41748405
25positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc6.40576724
26regulation of chemokine secretion (GO:0090196)6.32301639
27organic cation transport (GO:0015695)6.23018545
28histone H3-K9 demethylation (GO:0033169)6.16815215
29glucosamine-containing compound catabolic process (GO:1901072)6.15877234
30aromatic amino acid family catabolic process (GO:0009074)6.14942782
31production of molecular mediator involved in inflammatory response (GO:0002532)6.11139515
32sister chromatid cohesion (GO:0007062)6.09631423
33homocysteine metabolic process (GO:0050667)6.06508893
34drug catabolic process (GO:0042737)5.93767918
35regulation of histone H3-K9 methylation (GO:0051570)5.90340207
36response to mercury ion (GO:0046689)5.89004992
37reciprocal meiotic recombination (GO:0007131)5.71806550
38reciprocal DNA recombination (GO:0035825)5.71806550
39regulation of meiosis I (GO:0060631)5.67083129
40indole-containing compound catabolic process (GO:0042436)5.66303216
41indolalkylamine catabolic process (GO:0046218)5.66303216
42tryptophan catabolic process (GO:0006569)5.66303216
43sex differentiation (GO:0007548)5.60464765
44phosphate ion transmembrane transport (GO:0035435)5.48732610
45negative regulation of gene silencing (GO:0060969)5.40824266
46serine family amino acid catabolic process (GO:0009071)5.40021591
47aspartate family amino acid catabolic process (GO:0009068)5.38912336
48short-chain fatty acid metabolic process (GO:0046459)5.37173271
49quaternary ammonium group transport (GO:0015697)5.36421420
50tryptophan metabolic process (GO:0006568)5.36355914
51exogenous drug catabolic process (GO:0042738)5.32868600
52amino-acid betaine metabolic process (GO:0006577)5.07370667
53regulation of transcription from RNA polymerase I promoter (GO:0006356)5.07185267
54tricarboxylic acid metabolic process (GO:0072350)5.05015207
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.99360909
56kynurenine metabolic process (GO:0070189)4.93310601
57positive regulation of cellular response to oxidative stress (GO:1900409)4.92241514
58positive regulation of response to oxidative stress (GO:1902884)4.92241514
59serine family amino acid metabolic process (GO:0009069)4.91737369
60cellular modified amino acid catabolic process (GO:0042219)4.89697328
61excretion (GO:0007588)4.81655113
62vitamin D metabolic process (GO:0042359)4.77297054
63growth hormone receptor signaling pathway (GO:0060396)4.71741240
64histone H4-K12 acetylation (GO:0043983)4.70110640
65valine metabolic process (GO:0006573)4.68406769
66sulfur amino acid catabolic process (GO:0000098)4.65525953
67branched-chain amino acid metabolic process (GO:0009081)4.58493301
682-oxoglutarate metabolic process (GO:0006103)4.54442539
69glutamate metabolic process (GO:0006536)4.51684585
70alpha-amino acid catabolic process (GO:1901606)4.49912424
71aromatic amino acid family metabolic process (GO:0009072)4.48919347
72cellular ketone body metabolic process (GO:0046950)4.47470613
73renal absorption (GO:0070293)4.45651965
74cellular amino acid catabolic process (GO:0009063)4.39267115
75negative regulation of inclusion body assembly (GO:0090084)4.38414455
76serine family amino acid biosynthetic process (GO:0009070)4.32788752
77fatty acid beta-oxidation (GO:0006635)4.31897495
78acetyl-CoA metabolic process (GO:0006084)4.30195083
79embryonic body morphogenesis (GO:0010172)4.28708149
80nonribosomal peptide biosynthetic process (GO:0019184)4.20721401
81carnitine metabolic process (GO:0009437)4.17782274
82cellular response to growth hormone stimulus (GO:0071378)4.14821441
83fatty acid oxidation (GO:0019395)4.11364402
84proline metabolic process (GO:0006560)4.09409130
85carnitine transport (GO:0015879)4.08916176
86amino-acid betaine transport (GO:0015838)4.08916176
87branched-chain amino acid catabolic process (GO:0009083)4.08055640
88modified amino acid transport (GO:0072337)4.07222164
89lipid oxidation (GO:0034440)4.03452335
90aldehyde catabolic process (GO:0046185)4.03376299
91cilium or flagellum-dependent cell motility (GO:0001539)4.01512306
92bile acid biosynthetic process (GO:0006699)4.00356213
93gene silencing by RNA (GO:0031047)3.99338267
94indolalkylamine metabolic process (GO:0006586)3.98078954
95fructose metabolic process (GO:0006000)3.97618992
96amino sugar catabolic process (GO:0046348)3.94405634
97regulation of DNA endoreduplication (GO:0032875)3.93599059
98carboxylic acid catabolic process (GO:0046395)3.89888677
99organic acid catabolic process (GO:0016054)3.89888677
100metanephric tubule development (GO:0072170)3.89834653
101metanephric nephron tubule development (GO:0072234)3.89834653
102phosphate ion homeostasis (GO:0055062)3.87669697
103trivalent inorganic anion homeostasis (GO:0072506)3.87669697
104ketone body metabolic process (GO:1902224)3.84921146
105resolution of meiotic recombination intermediates (GO:0000712)3.80123531
106benzene-containing compound metabolic process (GO:0042537)3.79454790
107glutathione biosynthetic process (GO:0006750)3.78166550
108embryonic heart tube development (GO:0035050)3.77615078
109mating behavior (GO:0007617)3.77507495
110ethanol oxidation (GO:0006069)3.76521880
111response to misfolded protein (GO:0051788)3.75140405
112drug metabolic process (GO:0017144)3.74361201
113monocarboxylic acid catabolic process (GO:0072329)3.73846768
114fatty acid catabolic process (GO:0009062)3.73066981
115glucuronate metabolic process (GO:0019585)3.70305236
116uronic acid metabolic process (GO:0006063)3.70305236
117cellular biogenic amine catabolic process (GO:0042402)3.69186730
118amine catabolic process (GO:0009310)3.69186730
119cellular glucuronidation (GO:0052695)3.64545037
120indole-containing compound metabolic process (GO:0042430)3.64408668
121dicarboxylic acid biosynthetic process (GO:0043650)3.64066277
122metanephric nephron epithelium development (GO:0072243)3.62138826
123glycine metabolic process (GO:0006544)3.61356609
124toxin transport (GO:1901998)3.61313664
125positive regulation of meiosis (GO:0045836)3.56019024
126female gamete generation (GO:0007292)3.55501297
127urea metabolic process (GO:0019627)3.53610861
128urea cycle (GO:0000050)3.53610861
129tyrosine metabolic process (GO:0006570)3.53266651
130macroautophagy (GO:0016236)3.51920976
131response to growth hormone (GO:0060416)3.50074762
132reproductive system development (GO:0061458)3.49708939
133mitotic sister chromatid cohesion (GO:0007064)3.49163474
134regulation of NFAT protein import into nucleus (GO:0051532)3.48300448
135dicarboxylic acid metabolic process (GO:0043648)3.48205770
136regulation of cholesterol homeostasis (GO:2000188)3.47785566
137alpha-linolenic acid metabolic process (GO:0036109)3.45135137
138embryonic foregut morphogenesis (GO:0048617)3.44974801
139flavonoid metabolic process (GO:0009812)3.43904388
140body morphogenesis (GO:0010171)3.42322687
141regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.40101992
142small molecule catabolic process (GO:0044282)3.40065511
143glutathione derivative biosynthetic process (GO:1901687)3.39074680
144glutathione derivative metabolic process (GO:1901685)3.39074680
145DNA alkylation (GO:0006305)3.37691601
146DNA methylation (GO:0006306)3.37691601
147mitotic spindle assembly checkpoint (GO:0007094)3.35347520
148nitrogen cycle metabolic process (GO:0071941)3.34876519
149establishment of nucleus localization (GO:0040023)3.34618154
150glutathione metabolic process (GO:0006749)3.34250030
151spindle assembly checkpoint (GO:0071173)3.31876346
152metanephric epithelium development (GO:0072207)3.31620984
153positive regulation of meiotic cell cycle (GO:0051446)3.30127149
154biotin metabolic process (GO:0006768)3.28884972
155protein refolding (GO:0042026)3.26731909
156genitalia morphogenesis (GO:0035112)3.24925780
157misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.23087709
158negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14973644
159negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14973644
160negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14973644
161negative regulation of mitotic sister chromatid separation (GO:2000816)3.14973644
162negative regulation of sister chromatid segregation (GO:0033046)3.14973644
163nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.13994760
164mismatch repair (GO:0006298)3.13895117
165protein localization to chromosome (GO:0034502)3.09936605
166mitotic spindle checkpoint (GO:0071174)3.02514368
167negative regulation of chromosome segregation (GO:0051985)3.00255872
168chromosome organization (GO:0051276)2.92166116
169regulation of microtubule-based movement (GO:0060632)2.91577964
170striatum development (GO:0021756)2.89586344
171regulation of chromatin silencing (GO:0031935)2.88423112
172attachment of spindle microtubules to kinetochore (GO:0008608)2.88271110
173polysaccharide catabolic process (GO:0000272)2.86646614
174spermatid development (GO:0007286)2.82975013
175regulation of nuclear cell cycle DNA replication (GO:0033262)2.81731097
176histone H4-K16 acetylation (GO:0043984)2.77738381
177regulation of mitotic sister chromatid separation (GO:0010965)2.77102341
178regulation of mitotic sister chromatid segregation (GO:0033047)2.77102341
179regulation of sister chromatid segregation (GO:0033045)2.77102341
180spindle checkpoint (GO:0031577)2.76716935
181ncRNA 3-end processing (GO:0043628)2.75535830
182regulation of cilium movement (GO:0003352)2.73702398
183diterpenoid biosynthetic process (GO:0016102)2.69357857
184histone H2A acetylation (GO:0043968)2.69006186
185negative regulation of DNA-dependent DNA replication (GO:2000104)2.65431845
186regulation of response to food (GO:0032095)2.64994205
187nuclear division (GO:0000280)2.64044108
188artery smooth muscle contraction (GO:0014824)2.63363240
189kinetochore organization (GO:0051383)2.62977831
190regulation of meiotic cell cycle (GO:0051445)2.62112801
191male meiosis I (GO:0007141)12.9798495
192synapsis (GO:0007129)12.2445377
193chromosome organization involved in meiosis (GO:0070192)11.1238849
194meiosis I (GO:0007127)10.9623426
195synaptonemal complex assembly (GO:0007130)10.5956488
196synaptonemal complex organization (GO:0070193)10.3975298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.45873572
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.98627515
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.95865649
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.83825697
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.39131032
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.76354033
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.73858428
8SALL1_21062744_ChIP-ChIP_HESCs_Human4.53948649
9EGR1_23403033_ChIP-Seq_LIVER_Mouse4.34583544
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.67461115
11IGF1R_20145208_ChIP-Seq_DFB_Human3.44467419
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.26412079
13ZNF274_21170338_ChIP-Seq_K562_Hela2.99155757
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.81156029
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.79024870
16BCAT_22108803_ChIP-Seq_LS180_Human2.62997402
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.58755111
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.54946396
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.53620850
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45063888
21RNF2_27304074_Chip-Seq_NSC_Mouse2.42962693
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37264089
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18022004
24CLOCK_20551151_ChIP-Seq_293T_Human2.08439540
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.08099927
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07130412
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03804446
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.00395878
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99798361
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98347854
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88549277
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.86169872
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85853248
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.85127252
35TAF15_26573619_Chip-Seq_HEK293_Human1.83031064
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82807543
37ER_23166858_ChIP-Seq_MCF-7_Human1.81742219
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81400528
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.71743093
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66332699
41RUNX1_26923725_Chip-Seq_HPCs_Mouse1.63489202
42FOXH1_21741376_ChIP-Seq_EPCs_Human1.62072648
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.59816163
44HTT_18923047_ChIP-ChIP_STHdh_Human1.59276608
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59054488
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.58722613
47HNF4A_19822575_ChIP-Seq_HepG2_Human1.57557468
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.55460887
49TP53_22573176_ChIP-Seq_HFKS_Human1.55036517
50MYC_19829295_ChIP-Seq_ESCs_Human1.53700507
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.52733899
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52591524
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51931322
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48838262
55GATA3_26560356_Chip-Seq_TH1_Human1.48797989
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.48299565
57FOXA1_21572438_ChIP-Seq_LNCaP_Human1.48107030
58NCOR_22424771_ChIP-Seq_293T_Human1.47340033
59AR_21909140_ChIP-Seq_LNCAP_Human1.45412876
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.43087703
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.42371835
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39786931
63MYC_18940864_ChIP-ChIP_HL60_Human1.39697852
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37251940
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.37224649
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.36528480
67* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35937867
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35607453
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35553578
70GATA4_25053715_ChIP-Seq_YYC3_Human1.34322527
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33336422
72* ERA_21632823_ChIP-Seq_H3396_Human1.32820449
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31984266
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30138427
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28379179
76EGR1_19032775_ChIP-ChIP_M12_Human1.25997745
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24902822
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.23926576
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23345511
80TCF4_23295773_ChIP-Seq_U87_Human1.22210630
81E2F7_22180533_ChIP-Seq_HELA_Human1.22088143
82SOX2_21211035_ChIP-Seq_LN229_Human1.21350239
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20452404
84HOXB7_26014856_ChIP-Seq_BT474_Human1.18587369
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17951346
86* LXR_22292898_ChIP-Seq_THP-1_Human1.17497153
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17053414
88STAT3_23295773_ChIP-Seq_U87_Human1.16871732
89TCF4_22108803_ChIP-Seq_LS180_Human1.15262661
90EWS_26573619_Chip-Seq_HEK293_Human1.15082934
91EZH2_22144423_ChIP-Seq_EOC_Human1.14588328
92RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14403022
93VDR_22108803_ChIP-Seq_LS180_Human1.13704659
94SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13622754
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12631806
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11469025
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.10865736
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10487242
99SMC4_20622854_ChIP-Seq_HELA_Human1.10114677
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09749598
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.09710378
102TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09521966
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.08964186
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07957336
105BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.07571301
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.07111160
107ETV1_20927104_ChIP-Seq_GIST48_Human1.04671391
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03073247
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02243227
110RUNX2_22187159_ChIP-Seq_PCA_Human1.01918521
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.01604496
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.01500666
113FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01276767
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00316884
115TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00268328
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99822792
117RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99615000
118AR_21572438_ChIP-Seq_LNCaP_Human0.99530709
119GABP_19822575_ChIP-Seq_HepG2_Human0.99384441
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99069541
121GATA3_21867929_ChIP-Seq_TH1_Mouse0.98991022
122KDM5A_27292631_Chip-Seq_BREAST_Human0.98620905
123GABP_17652178_ChIP-ChIP_JURKAT_Human0.97609215
124GATA6_25053715_ChIP-Seq_YYC3_Human0.97381097
125CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96754988
126CBX2_27304074_Chip-Seq_ESCs_Mouse0.96712096
127RACK7_27058665_Chip-Seq_MCF-7_Human0.96410068
128FUS_26573619_Chip-Seq_HEK293_Human0.96158562
129STAT1_17558387_ChIP-Seq_HELA_Human0.96156896
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95783103
131AR_25329375_ChIP-Seq_VCAP_Human0.95482876
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93676664
133DCP1A_22483619_ChIP-Seq_HELA_Human0.93132290
134TP53_16413492_ChIP-PET_HCT116_Human0.92683566
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90577995
136P68_20966046_ChIP-Seq_HELA_Human0.90466018
137WDR5_24793694_ChIP-Seq_LNCAP_Human0.90408083
138P300_19829295_ChIP-Seq_ESCs_Human0.90244294
139KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90107396
140KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90107396
141SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84820462
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.83472031
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.83472031
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83404278
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79340484
146FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77905252
147SOX2_20726797_ChIP-Seq_SW620_Human0.75824873
148* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74356579
149* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74239040
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.73676057
151MYC_19915707_ChIP-ChIP_AK7_Human0.73167991
152ZNF263_19887448_ChIP-Seq_K562_Human0.72867162
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71914320
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.71468390
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70911264
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70655836
157NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70399957
158NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70399957
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69635621
160NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68982867
161CDX2_22108803_ChIP-Seq_LS180_Human0.68905226
162FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67697784
163Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65223893
164RXR_22108803_ChIP-Seq_LS180_Human0.64953709
165GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.64219181
166P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.63939576
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.63433033
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.62673700
169GATA1_22025678_ChIP-Seq_K562_Human0.62667558
170EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62599258
171CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.62396341
172CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62114886
173RAC3_21632823_ChIP-Seq_H3396_Human0.61141059
174SOX2_18692474_ChIP-Seq_MEFs_Mouse0.59385713
175AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59366746
176CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.59359781
177* TAF2_19829295_ChIP-Seq_ESCs_Human0.59257820
178GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.59116941
179CSB_26484114_Chip-Seq_FIBROBLAST_Human0.59077053
180CEBPB_22108803_ChIP-Seq_LS180_Human0.58941855
181TP63_23658742_ChIP-Seq_EP156T_Human0.58818327
182GATA2_19941826_ChIP-Seq_K562_Human0.57901539
183AR_20517297_ChIP-Seq_VCAP_Human0.57543049
184EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.56507268
185FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.56187015
186P63_26484246_Chip-Seq_KERATINOCYTES_Human0.55723198
187ESET_19884257_ChIP-Seq_ESCs_Mouse0.55700221
188CTCF_27219007_Chip-Seq_Bcells_Human0.55408080
189NANOG_18692474_ChIP-Seq_MEFs_Mouse0.54672190
190ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.54346423
191GATA1_19941826_ChIP-Seq_K562_Human0.54108607
192TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.53976496
193SOX11_22085726_ChIP-Seq_ESNs_Mouse0.53776845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.51797556
2MP0008877_abnormal_DNA_methylation7.37271711
3MP0002139_abnormal_hepatobiliary_system5.98631308
4MP0004043_abnormal_pH_regulation5.10676799
5MP0005332_abnormal_amino_acid4.61746329
6MP0003195_calcinosis4.60335458
7MP0004019_abnormal_vitamin_homeostasis4.51036634
8MP0005365_abnormal_bile_salt3.95167279
9MP0008875_abnormal_xenobiotic_pharmacok3.87859420
10MP0002210_abnormal_sex_determination3.85663994
11MP0005085_abnormal_gallbladder_physiolo3.81893816
12MP0002160_abnormal_reproductive_system3.77306517
13MP0003136_yellow_coat_color3.55887880
14MP0009643_abnormal_urine_homeostasis3.39681734
15MP0002277_abnormal_respiratory_mucosa3.31595187
16MP0002138_abnormal_hepatobiliary_system3.27669476
17MP0003252_abnormal_bile_duct3.23308117
18MP0001929_abnormal_gametogenesis3.12046666
19MP0001765_abnormal_ion_homeostasis3.00142009
20MP0001145_abnormal_male_reproductive2.89370918
21MP0008995_early_reproductive_senescence2.87049915
22MP0003698_abnormal_male_reproductive2.73917943
23MP0005636_abnormal_mineral_homeostasis2.73419122
24MP0001756_abnormal_urination2.64290738
25MP0003806_abnormal_nucleotide_metabolis2.63887027
26MP0008058_abnormal_DNA_repair2.61291721
27MP0000653_abnormal_sex_gland2.61057033
28MP0000647_abnormal_sebaceous_gland2.58614942
29MP0000383_abnormal_hair_follicle2.51235370
30MP0000678_abnormal_parathyroid_gland2.49197390
31MP0005389_reproductive_system_phenotype2.45080423
32MP0002136_abnormal_kidney_physiology2.43774216
33MP0005409_darkened_coat_color2.35361157
34MP0000427_abnormal_hair_cycle2.30676348
35MP0005174_abnormal_tail_pigmentation2.14973257
36MP0000569_abnormal_digit_pigmentation1.97350712
37MP0003878_abnormal_ear_physiology1.88638611
38MP0005377_hearing/vestibular/ear_phenot1.88638611
39MP0010678_abnormal_skin_adnexa1.88046130
40MP0003119_abnormal_digestive_system1.86132489
41MP0010329_abnormal_lipoprotein_level1.85247976
42MP0003186_abnormal_redox_activity1.83005232
43MP0003943_abnormal_hepatobiliary_system1.81425077
44MP0005451_abnormal_body_composition1.81277355
45MP0010094_abnormal_chromosome_stability1.72934225
46MP0005584_abnormal_enzyme/coenzyme_acti1.71515043
47MP0000015_abnormal_ear_pigmentation1.68881573
48MP0005319_abnormal_enzyme/_coenzyme1.65092504
49MP0001243_abnormal_dermal_layer1.65049351
50MP0001958_emphysema1.63684867
51MP0002095_abnormal_skin_pigmentation1.61067040
52MP0005645_abnormal_hypothalamus_physiol1.52394798
53MP0008961_abnormal_basal_metabolism1.50860369
54MP0001666_abnormal_nutrient_absorption1.50086181
55MP0003011_delayed_dark_adaptation1.48326344
56MP0003786_premature_aging1.45277008
57MP0002736_abnormal_nociception_after1.44527805
58MP0001486_abnormal_startle_reflex1.41369979
59MP0002118_abnormal_lipid_homeostasis1.38682977
60MP0003191_abnormal_cellular_cholesterol1.37438347
61MP0001984_abnormal_olfaction1.36171291
62MP0008007_abnormal_cellular_replicative1.34831659
63MP0001119_abnormal_female_reproductive1.34033307
64MP0001919_abnormal_reproductive_system1.33998510
65MP0001764_abnormal_homeostasis1.33930516
66MP0008260_abnormal_autophagy1.30756628
67MP0009379_abnormal_foot_pigmentation1.29593095
68MP0002161_abnormal_fertility/fecundity1.28938932
69MP0005551_abnormal_eye_electrophysiolog1.28866822
70MP0000538_abnormal_urinary_bladder1.26591878
71MP0005058_abnormal_lysosome_morphology1.25532303
72MP0004885_abnormal_endolymph1.25166740
73MP0005083_abnormal_biliary_tract1.24532964
74MP0000609_abnormal_liver_physiology1.23992935
75MP0008004_abnormal_stomach_pH1.19895876
76MP0006036_abnormal_mitochondrial_physio1.19884472
77MP0003693_abnormal_embryo_hatching1.16215629
78MP0006292_abnormal_olfactory_placode1.13565657
79MP0000230_abnormal_systemic_arterial1.10804859
80MP0003111_abnormal_nucleus_morphology1.10758138
81MP0002168_other_aberrant_phenotype1.09901243
82MP0005084_abnormal_gallbladder_morpholo1.09791056
83MP0003936_abnormal_reproductive_system1.08756194
84MP0002928_abnormal_bile_duct1.07716906
85MP0002876_abnormal_thyroid_physiology1.06262084
86MP0009840_abnormal_foam_cell1.01250647
87MP0003300_gastrointestinal_ulcer0.99271270
88MP0003937_abnormal_limbs/digits/tail_de0.96527657
89MP0004381_abnormal_hair_follicle0.96235406
90MP0005670_abnormal_white_adipose0.95374675
91MP0002163_abnormal_gland_morphology0.95017101
92MP0005535_abnormal_body_temperature0.93382815
93MP0003183_abnormal_peptide_metabolism0.93298904
94MP0009764_decreased_sensitivity_to0.92119126
95MP0003763_abnormal_thymus_physiology0.91833531
96MP0002135_abnormal_kidney_morphology0.91348902
97MP0008789_abnormal_olfactory_epithelium0.91253667
98MP0004808_abnormal_hematopoietic_stem0.89544514
99MP0001968_abnormal_touch/_nociception0.86998005
100MP0002249_abnormal_larynx_morphology0.86296644
101MP0009642_abnormal_blood_homeostasis0.85866399
102MP0005666_abnormal_adipose_tissue0.85110984
103MP0002896_abnormal_bone_mineralization0.83734345
104MP0003699_abnormal_female_reproductive0.83139091
105MP0003453_abnormal_keratinocyte_physiol0.82293583
106MP0004036_abnormal_muscle_relaxation0.81436672
107MP0003077_abnormal_cell_cycle0.80921813
108MP0003638_abnormal_response/metabolism_0.79168104
109MP0002084_abnormal_developmental_patter0.78643865
110MP0000598_abnormal_liver_morphology0.77659948
111MP0005671_abnormal_response_to0.77117000
112MP0001485_abnormal_pinna_reflex0.73695777
113MP0005395_other_phenotype0.72560701
114MP0005220_abnormal_exocrine_pancreas0.72114732
115MP0000358_abnormal_cell_content/0.71262691
116MP0005310_abnormal_salivary_gland0.70028409
117MP0005408_hypopigmentation0.69328937
118MP0004264_abnormal_extraembryonic_tissu0.69321077
119MP0003938_abnormal_ear_development0.69152124
120MP0000013_abnormal_adipose_tissue0.68761473
121MP0010234_abnormal_vibrissa_follicle0.68242714
122MP0008469_abnormal_protein_level0.67665418
123MP0000372_irregular_coat_pigmentation0.67408594
124MP0001661_extended_life_span0.66871489
125MP0002796_impaired_skin_barrier0.62231250
126MP0008057_abnormal_DNA_replication0.59719694
127MP0003705_abnormal_hypodermis_morpholog0.58849073
128MP0010771_integument_phenotype0.58729176
129MP0002078_abnormal_glucose_homeostasis0.58309343
130MP0004147_increased_porphyrin_level0.57928769
131MP0000703_abnormal_thymus_morphology0.57817319
132MP0004233_abnormal_muscle_weight0.57564403
133MP0005253_abnormal_eye_physiology0.57546691
134MP0000604_amyloidosis0.57128919
135MP0005410_abnormal_fertilization0.57065097
136MP0005187_abnormal_penis_morphology0.55678553
137MP0004185_abnormal_adipocyte_glucose0.54150184
138MP0003329_amyloid_beta_deposits0.54093683
139MP0005448_abnormal_energy_balance0.53092251
140MP0004145_abnormal_muscle_electrophysio0.52938559
141MP0003283_abnormal_digestive_organ0.51683102
142MP0002075_abnormal_coat/hair_pigmentati0.51178915
143MP0001191_abnormal_skin_condition0.50564078
144MP0009703_decreased_birth_body0.50444152
145MP0006035_abnormal_mitochondrial_morpho0.49740802
146MP0002089_abnormal_postnatal_growth/wei0.49719302
147MP0005165_increased_susceptibility_to0.48851901
148MP0001216_abnormal_epidermal_layer0.47503662
149MP0005376_homeostasis/metabolism_phenot0.46812805
150MP0003646_muscle_fatigue0.46636907
151MP0003953_abnormal_hormone_level0.46488121
152MP0005499_abnormal_olfactory_system0.45776907
153MP0005394_taste/olfaction_phenotype0.45776907
154MP0003959_abnormal_lean_body0.44376484
155MP0009765_abnormal_xenobiotic_induced0.42682462
156MP0002971_abnormal_brown_adipose0.41126177
157MP0009763_increased_sensitivity_to0.40555600
158MP0005647_abnormal_sex_gland0.40227492
159MP0005501_abnormal_skin_physiology0.39919688
160MP0003075_altered_response_to0.39386563
161MP0003868_abnormal_feces_composition0.38385012
162MP0000747_muscle_weakness0.37967097
163MP0005167_abnormal_blood-brain_barrier0.37773579
164MP0002115_abnormal_skeleton_extremities0.37552403
165MP0009672_abnormal_birth_weight0.36875849
166MP0002069_abnormal_eating/drinking_beha0.36436244
167MP0009053_abnormal_anal_canal0.35329451
168MP0005166_decreased_susceptibility_to0.34359665
169MP0008872_abnormal_physiological_respon0.33723633
170MP0002254_reproductive_system_inflammat0.33425190
171MP0000371_diluted_coat_color0.33415383
172MP0003172_abnormal_lysosome_physiology0.32546790
173MP0002098_abnormal_vibrissa_morphology0.32313903
174MP0001270_distended_abdomen0.31953529
175MP0005266_abnormal_metabolism0.31123514
176MP0000163_abnormal_cartilage_morphology0.30423011
177MP0005375_adipose_tissue_phenotype0.29500552
178MP0002998_abnormal_bone_remodeling0.28771188
179MP0003795_abnormal_bone_structure0.28664140
180MP0004272_abnormal_basement_membrane0.28004989
181MP0004858_abnormal_nervous_system0.27953314

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.63129529
2Hypokalemic alkalosis (HP:0001949)6.85468455
3Metabolic alkalosis (HP:0200114)6.48408412
4Gout (HP:0001997)6.33222112
5Hyperactive renin-angiotensin system (HP:0000841)6.31752338
6Hypomagnesemia (HP:0002917)6.15477729
7Polyuria (HP:0000103)5.90669901
8Abnormal urine output (HP:0012590)5.61145222
9Abnormality of chloride homeostasis (HP:0011422)5.52505228
10Amyotrophic lateral sclerosis (HP:0007354)5.47430348
11Type I transferrin isoform profile (HP:0003642)5.38598389
12Abnormality of glutamine family amino acid metabolism (HP:0010902)5.24958563
13Abnormality of renal excretion (HP:0011036)5.24481550
14Abnormality of magnesium homeostasis (HP:0004921)5.16610670
15Horizontal nystagmus (HP:0000666)5.15485766
16Hyperglycinuria (HP:0003108)5.06930335
17Alkalosis (HP:0001948)4.93509456
18Proximal tubulopathy (HP:0000114)4.91313187
19Abnormal drinking behavior (HP:0030082)4.72673516
20Polydipsia (HP:0001959)4.72673516
21Increased purine levels (HP:0004368)4.60064703
22Hyperuricemia (HP:0002149)4.60064703
23Shoulder girdle muscle weakness (HP:0003547)4.59049909
24Abnormal protein glycosylation (HP:0012346)4.57244052
25Abnormal glycosylation (HP:0012345)4.57244052
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.57244052
27Abnormal protein N-linked glycosylation (HP:0012347)4.57244052
28Abnormality of renin-angiotensin system (HP:0000847)4.53567984
29Tetany (HP:0001281)4.39954632
30Renal salt wasting (HP:0000127)4.37046082
31Abnormality of serine family amino acid metabolism (HP:0010894)4.33298909
32Abnormality of glycine metabolism (HP:0010895)4.33298909
33Abnormality of purine metabolism (HP:0004352)4.30827372
34Hyperaldosteronism (HP:0000859)4.15267231
35Rimmed vacuoles (HP:0003805)4.12487675
36Attenuation of retinal blood vessels (HP:0007843)4.06072967
37Generalized aminoaciduria (HP:0002909)3.93830728
38Abnormality of the lower motor neuron (HP:0002366)3.89846443
39Abnormality of aromatic amino acid family metabolism (HP:0004338)3.89240934
4011 pairs of ribs (HP:0000878)3.83142486
41Volvulus (HP:0002580)3.69558047
42Ketosis (HP:0001946)3.66953729
43Ketoacidosis (HP:0001993)3.65101813
44Degeneration of the lateral corticospinal tracts (HP:0002314)3.55546539
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.55546539
46Abnormality of aspartate family amino acid metabolism (HP:0010899)3.53621129
47Abnormality of nucleobase metabolism (HP:0010932)3.52113830
48Oligodactyly (hands) (HP:0001180)3.47471518
49Hyperglycinemia (HP:0002154)3.43384330
50Hypercalciuria (HP:0002150)3.37594977
51Hydroxyprolinuria (HP:0003080)3.33145630
52Abnormality of proline metabolism (HP:0010907)3.33145630
53Hypokalemia (HP:0002900)3.33124288
54Abnormality of urine glucose concentration (HP:0011016)3.33074178
55Glycosuria (HP:0003076)3.33074178
56Renal tubular acidosis (HP:0001947)3.32666248
57Tubulointerstitial nephritis (HP:0001970)3.30090585
58Gonadotropin excess (HP:0000837)3.27087665
59Hyperammonemia (HP:0001987)3.26965900
60Abnormality of fatty-acid metabolism (HP:0004359)3.23330073
61Upper motor neuron abnormality (HP:0002127)3.20894267
62Atrophy/Degeneration involving motor neurons (HP:0007373)3.13746581
63Delayed CNS myelination (HP:0002188)3.01151518
64Abnormality of sulfur amino acid metabolism (HP:0004339)2.99968210
65Xanthomatosis (HP:0000991)2.99339439
66Azoospermia (HP:0000027)2.97775667
67Hyperphosphaturia (HP:0003109)2.88590103
68Vascular calcification (HP:0004934)2.87031261
69Abnormality of potassium homeostasis (HP:0011042)2.84410026
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.83541610
71Poikiloderma (HP:0001029)2.82861826
72Abnormality of permanent molar morphology (HP:0011071)2.81304214
73Abnormality of the dental root (HP:0006486)2.81304214
74Taurodontia (HP:0000679)2.81304214
75Delayed epiphyseal ossification (HP:0002663)2.77044108
76Intrahepatic cholestasis (HP:0001406)2.76613578
77Rickets (HP:0002748)2.76544566
78Abnormal urine phosphate concentration (HP:0012599)2.72732038
79Nephrolithiasis (HP:0000787)2.71022936
80Nephrocalcinosis (HP:0000121)2.64008880
81Metabolic acidosis (HP:0001942)2.58784219
82Malnutrition (HP:0004395)2.57974639
83Abnormality of molar morphology (HP:0011070)2.57688971
84Abnormality of molar (HP:0011077)2.57688971
85Cardiovascular calcification (HP:0011915)2.54872038
86Hypophosphatemia (HP:0002148)2.54503356
87Large hands (HP:0001176)2.54206732
88Dicarboxylic aciduria (HP:0003215)2.52221965
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52221965
90Osteomalacia (HP:0002749)2.51293562
91Abnormality of the dental pulp (HP:0006479)2.45195457
92Enlarged kidneys (HP:0000105)2.42936482
93Vomiting (HP:0002013)2.42885358
94Abnormality of the corticospinal tract (HP:0002492)2.38608453
95Aplasia/Hypoplasia of the sternum (HP:0006714)2.35517409
96Dehydration (HP:0001944)2.34919613
97Widely patent fontanelles and sutures (HP:0004492)2.34897719
98Metaphyseal cupping (HP:0003021)2.32284431
99Abnormality of the renal medulla (HP:0100957)2.32052093
100Lethargy (HP:0001254)2.31718531
101Deep venous thrombosis (HP:0002625)2.30130866
102Abnormal enzyme/coenzyme activity (HP:0012379)2.28853322
103Diastasis recti (HP:0001540)2.28813865
104Abnormality of DNA repair (HP:0003254)2.27513321
105Status epilepticus (HP:0002133)2.27148499
106Anhidrosis (HP:0000970)2.26464656
107Broad distal phalanx of finger (HP:0009836)2.26062742
108Colon cancer (HP:0003003)2.23452698
109Abnormality of sodium homeostasis (HP:0010931)2.21689486
110Non-midline cleft lip (HP:0100335)2.21554795
111Squamous cell carcinoma (HP:0002860)2.19481629
112Increased nuchal translucency (HP:0010880)2.19241391
113Abnormality of serum amino acid levels (HP:0003112)2.18669165
114Hyponatremia (HP:0002902)2.18355617
115Abnormality of alkaline phosphatase activity (HP:0004379)2.16512331
116Short nail (HP:0001799)2.16297322
117Confusion (HP:0001289)2.16220596
118Hypoglycemic coma (HP:0001325)2.15138657
119Abnormality of the vocal cords (HP:0008777)2.14781024
120Spontaneous abortion (HP:0005268)2.13719530
121Abnormal tarsal ossification (HP:0008369)2.11626234
122Irritability (HP:0000737)2.07078883
123Chondrocalcinosis (HP:0000934)2.06269008
124Renal tubular dysfunction (HP:0000124)2.05304818
125Neonatal onset (HP:0003623)2.03981501
126Hoarse voice (HP:0001609)2.03545165
127Facial shape deformation (HP:0011334)2.01948938
128Potter facies (HP:0002009)2.01948938
129Hepatocellular carcinoma (HP:0001402)1.98954674
130Ectopic kidney (HP:0000086)1.98871366
131Genetic anticipation (HP:0003743)1.98466777
132Abnormal spermatogenesis (HP:0008669)1.98314289
133Entropion (HP:0000621)1.98208052
134Abnormality of Sharpey fibers (HP:0100685)1.95754386
135Abnormality of pyrimidine metabolism (HP:0004353)1.94686748
136Oligodactyly (HP:0012165)1.94681902
137Rhizomelia (HP:0008905)1.94493385
138Abnormality of renal resorption (HP:0011038)1.94269698
139Lymphangioma (HP:0100764)1.92643465
140Poor coordination (HP:0002370)1.92178750
141Spastic diplegia (HP:0001264)1.92007934
142Hypoplastic iliac wings (HP:0002866)1.89308921
143Intellectual disability, moderate (HP:0002342)1.88781370
144Vacuolated lymphocytes (HP:0001922)1.88579007
145Septo-optic dysplasia (HP:0100842)1.88502814
146Glomerulosclerosis (HP:0000096)1.88147800
147Nephrogenic diabetes insipidus (HP:0009806)1.87796827
148Nausea (HP:0002018)1.86755981
149Hypophosphatemic rickets (HP:0004912)1.86459455
150Elevated alkaline phosphatase (HP:0003155)1.85836866
151Adrenal overactivity (HP:0002717)1.82999779
152Bilateral sensorineural hearing impairment (HP:0008619)1.81990349
153Urinary urgency (HP:0000012)1.81530508
154Methylmalonic aciduria (HP:0012120)1.81185762
155Hyperkalemia (HP:0002153)1.81054902
156Abnormality of cochlea (HP:0000375)1.80785259
157Aplasia/Hypoplasia of the nipples (HP:0006709)1.80711643
158Limb-girdle muscle weakness (HP:0003325)1.77631044
159Tubulointerstitial fibrosis (HP:0005576)1.77475730
160Tubular atrophy (HP:0000092)1.73564185
161Nephroblastoma (Wilms tumor) (HP:0002667)1.73555228
162Cystic liver disease (HP:0006706)1.72018572
163Axonal loss (HP:0003447)1.71828596
164Abnormality of the septum pellucidum (HP:0007375)1.69777848
165Neonatal hypoglycemia (HP:0001998)1.69531236
166Lip pit (HP:0100267)1.69326764
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.69205545
168Absent/shortened dynein arms (HP:0200106)1.69205545
169Absent speech (HP:0001344)1.68839023
170Protuberant abdomen (HP:0001538)1.67937603
171Abnormality of the motor neurons (HP:0002450)1.67502872
172Abnormal neuron morphology (HP:0012757)1.67502872
173Hypobetalipoproteinemia (HP:0003563)1.67460494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK49.03039970
2PNCK8.66132860
3OXSR17.36578521
4WNK37.33058047
5STK394.76541137
6MUSK4.40018902
7BCKDK3.68999226
8CSF1R3.53997911
9CAMK1G3.38750941
10FGR3.08757235
11CDK192.73639258
12TESK22.26508748
13STK38L2.23680393
14EPHA21.93094050
15PDGFRB1.79917388
16SGK2231.72341336
17SGK4941.72341336
18WNK11.65187957
19FGFR41.64548930
20NEK11.63360045
21MAP3K101.53379993
22PDK41.53331596
23PDK31.53331596
24CASK1.51076407
25RET1.46045414
26LATS21.43331821
27TAF11.36842025
28MST1R1.31821333
29PLK21.31456792
30MAP3K91.22359270
31PDK21.20940953
32ERN11.17614269
33STK381.07401725
34SIK11.07040221
35EPHB11.02230117
36MAP4K11.02049206
37ADRBK10.99917449
38SGK30.93811949
39SGK20.93598180
40INSRR0.92024778
41PASK0.86075895
42GSK3A0.84768083
43LRRK20.84040521
44MAP3K30.82469597
45PINK10.81345310
46NEK60.80683347
47MST40.79714845
48TIE10.78987547
49MAP3K50.77869321
50ACVR1B0.77816542
51GRK60.77152245
52MAP3K70.73119977
53EGFR0.72608132
54PTK60.69752051
55BUB10.69030776
56MAP3K120.67474110
57DYRK1B0.66075403
58ATR0.64875957
59ABL20.64818682
60NTRK30.64158044
61TAOK20.64052195
62TGFBR20.61286630
63WEE10.59961202
64PTK20.59701568
65MAPK110.59141651
66CAMKK10.58478628
67TRIB30.57299065
68GRK70.57182468
69TTK0.56007869
70PRPF4B0.55380021
71YES10.53657797
72ERBB40.53199396
73RPS6KB10.52516755
74PRKAA10.51810224
75LATS10.50112344
76PLK10.49333233
77PRKAA20.48622359
78SGK10.48601650
79MAP2K40.47990694
80CAMK10.46765485
81MET0.43600787
82PDPK10.42909397
83PAK40.40674889
84TYRO30.40356403
85LIMK10.40151237
86CHEK10.39876316
87PIK3CG0.38914165
88PRKCZ0.37471488
89FER0.36060285
90PAK30.35947043
91TSSK60.35204204
92MAP2K20.35041338
93MAPK150.34384008
94FRK0.33347978
95PKN20.33070228
96MAPK130.33022443
97MINK10.32074842
98RIPK10.31673178
99MAPKAPK30.31400840
100MAP3K140.30817635
101PLK40.30234966
102MAP2K30.30108905
103MARK30.29779129
104PRKACG0.29722449
105IRAK20.28626263
106CDK11A0.28012598
107MAP3K20.26836877
108STK100.26533421
109KDR0.26449989
110CSNK1E0.25961686
111NUAK10.25739155
112PDK10.25194634
113JAK20.25165795
114NTRK10.25016353
115ATM0.24384632
116MELK0.23826547
117TYK20.23266306
118BRSK10.22855619
119MAPK120.22092403
120BRAF0.20805193
121NME10.20201847
122DAPK10.19875818
123ERBB20.19122973
124PRKCI0.19110570
125PTK2B0.18127703
126AURKA0.17667287
127PRKD20.17024997
128DAPK20.16418902
129CDK40.16379997
130MAPK40.16191325
131EPHB20.16119579
132MAPK30.16004882
133PRKCD0.15383156
134BMX0.15302579
135STK110.13711593
136CSK0.13586245
137PRKCA0.13318734
138TXK0.13266302
139PRKACA0.13219215
140AKT20.13209895
141IKBKE0.13198084
142EPHA40.12979963
143MAP3K60.12239758
144KSR10.11677669
145CDK60.11292764
146MYLK0.11000797
147CDK50.10602374
148MTOR0.10375893
149PRKCG0.08819021
150MAP2K10.08787131
151MAP2K60.08544540
152PBK0.08226246
153CSNK1G20.08183687
154PRKCH0.08145758
155NEK20.08015369
156NME20.07748976
157ROCK10.07632008
158IGF1R0.07340729
159CSNK2A10.07262764
160NEK90.07018186
161PRKCQ0.06826286
162MAP3K110.06351308
163INSR0.05945483
164CAMK40.05769471
165PRKD10.05529124
166FGFR20.04581341

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034404.01125419
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.74666636
3Phototransduction_Homo sapiens_hsa047443.44167705
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.21706089
5Butanoate metabolism_Homo sapiens_hsa006503.15564723
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.08249647
7Propanoate metabolism_Homo sapiens_hsa006402.92145773
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.92027460
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84429470
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83060635
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.70222964
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.69813777
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.65603770
14Fanconi anemia pathway_Homo sapiens_hsa034602.62465038
15Mismatch repair_Homo sapiens_hsa034302.62242326
16Fatty acid degradation_Homo sapiens_hsa000712.60854556
17Tryptophan metabolism_Homo sapiens_hsa003802.53227461
18Nucleotide excision repair_Homo sapiens_hsa034202.50687481
19Nitrogen metabolism_Homo sapiens_hsa009102.46746328
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41822171
21Primary bile acid biosynthesis_Homo sapiens_hsa001202.39662276
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37832057
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.32885028
24Peroxisome_Homo sapiens_hsa041462.31347744
25N-Glycan biosynthesis_Homo sapiens_hsa005102.24692037
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.20219663
27Oocyte meiosis_Homo sapiens_hsa041142.09928903
28RNA transport_Homo sapiens_hsa030132.08028507
29Arginine biosynthesis_Homo sapiens_hsa002202.07335463
30Pyruvate metabolism_Homo sapiens_hsa006202.01435768
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00284965
32beta-Alanine metabolism_Homo sapiens_hsa004101.99217909
33RNA degradation_Homo sapiens_hsa030181.93767019
34ErbB signaling pathway_Homo sapiens_hsa040121.87184013
35Cell cycle_Homo sapiens_hsa041101.85273619
36Base excision repair_Homo sapiens_hsa034101.84428637
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84117776
38Fatty acid metabolism_Homo sapiens_hsa012121.82218865
39Taste transduction_Homo sapiens_hsa047421.80708858
40Vitamin digestion and absorption_Homo sapiens_hsa049771.72574245
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.70852423
42Bile secretion_Homo sapiens_hsa049761.68209802
43DNA replication_Homo sapiens_hsa030301.67019082
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65301656
45Sulfur metabolism_Homo sapiens_hsa009201.58779099
46Carbon metabolism_Homo sapiens_hsa012001.58328362
47Basal transcription factors_Homo sapiens_hsa030221.57293132
48mRNA surveillance pathway_Homo sapiens_hsa030151.54770515
49Nicotine addiction_Homo sapiens_hsa050331.53715201
50PPAR signaling pathway_Homo sapiens_hsa033201.53477109
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51565473
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48724700
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47270676
54Histidine metabolism_Homo sapiens_hsa003401.45415400
55Shigellosis_Homo sapiens_hsa051311.45135496
56Collecting duct acid secretion_Homo sapiens_hsa049661.37551981
57Glutathione metabolism_Homo sapiens_hsa004801.36810214
58Phenylalanine metabolism_Homo sapiens_hsa003601.36770624
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36480929
60Linoleic acid metabolism_Homo sapiens_hsa005911.33121487
61Selenocompound metabolism_Homo sapiens_hsa004501.32254021
62Chemical carcinogenesis_Homo sapiens_hsa052041.31656765
63Arginine and proline metabolism_Homo sapiens_hsa003301.31113742
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30681397
65SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27031081
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.24482405
67Starch and sucrose metabolism_Homo sapiens_hsa005001.22551797
68Lysine degradation_Homo sapiens_hsa003101.21746249
69Legionellosis_Homo sapiens_hsa051341.18592012
70Biosynthesis of amino acids_Homo sapiens_hsa012301.18132437
71Drug metabolism - other enzymes_Homo sapiens_hsa009831.15114902
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13246472
73Olfactory transduction_Homo sapiens_hsa047401.12429324
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12247455
75Folate biosynthesis_Homo sapiens_hsa007901.10671052
76Primary immunodeficiency_Homo sapiens_hsa053401.08865890
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08078166
78RNA polymerase_Homo sapiens_hsa030201.06308686
79Retinol metabolism_Homo sapiens_hsa008301.05420366
80Pyrimidine metabolism_Homo sapiens_hsa002401.04990704
81Complement and coagulation cascades_Homo sapiens_hsa046101.03849373
82Cysteine and methionine metabolism_Homo sapiens_hsa002701.01999571
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97755476
84Fatty acid elongation_Homo sapiens_hsa000620.96193330
85Small cell lung cancer_Homo sapiens_hsa052220.93888456
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87775688
87Antigen processing and presentation_Homo sapiens_hsa046120.85742207
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84643418
89Tyrosine metabolism_Homo sapiens_hsa003500.81767939
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80564042
91Protein digestion and absorption_Homo sapiens_hsa049740.79868751
92Mineral absorption_Homo sapiens_hsa049780.79408733
93Glycerolipid metabolism_Homo sapiens_hsa005610.79320352
94Steroid biosynthesis_Homo sapiens_hsa001000.72463501
95ABC transporters_Homo sapiens_hsa020100.71036929
96Salmonella infection_Homo sapiens_hsa051320.69685448
97Huntingtons disease_Homo sapiens_hsa050160.69529304
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68393884
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.66747648
100Epstein-Barr virus infection_Homo sapiens_hsa051690.64798540
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63070457
102Pentose phosphate pathway_Homo sapiens_hsa000300.61988812
103Fructose and mannose metabolism_Homo sapiens_hsa000510.61517299
104Glutamatergic synapse_Homo sapiens_hsa047240.60779489
105Synaptic vesicle cycle_Homo sapiens_hsa047210.60730258
106Hedgehog signaling pathway_Homo sapiens_hsa043400.58736172
107Other glycan degradation_Homo sapiens_hsa005110.58264299
108T cell receptor signaling pathway_Homo sapiens_hsa046600.53284835
109MAPK signaling pathway_Homo sapiens_hsa040100.52555538
110Renin-angiotensin system_Homo sapiens_hsa046140.52197861
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51632395
112Metabolic pathways_Homo sapiens_hsa011000.51035742
113Caffeine metabolism_Homo sapiens_hsa002320.49028917
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.48716793
115Purine metabolism_Homo sapiens_hsa002300.46603213
116Staphylococcus aureus infection_Homo sapiens_hsa051500.45727249
117Sulfur relay system_Homo sapiens_hsa041220.45348055
118Ribosome_Homo sapiens_hsa030100.44483156
119Circadian rhythm_Homo sapiens_hsa047100.44306598
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44257121
121Adherens junction_Homo sapiens_hsa045200.43381073
122Ether lipid metabolism_Homo sapiens_hsa005650.42577615
123Endocytosis_Homo sapiens_hsa041440.42464252
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42185820
125Calcium signaling pathway_Homo sapiens_hsa040200.41053712
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39841891
127VEGF signaling pathway_Homo sapiens_hsa043700.39228078
128Inositol phosphate metabolism_Homo sapiens_hsa005620.39137571
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37494115
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35845121
131Thyroid hormone synthesis_Homo sapiens_hsa049180.33647777
132Fat digestion and absorption_Homo sapiens_hsa049750.32719797
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31747093
134One carbon pool by folate_Homo sapiens_hsa006700.30899289
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.30861878
136mTOR signaling pathway_Homo sapiens_hsa041500.29496658
137Oxidative phosphorylation_Homo sapiens_hsa001900.27874093
138Endometrial cancer_Homo sapiens_hsa052130.26716259
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26148512
140Prostate cancer_Homo sapiens_hsa052150.25442484
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25179526
142Axon guidance_Homo sapiens_hsa043600.24753141
143Insulin signaling pathway_Homo sapiens_hsa049100.24418536
144Proteasome_Homo sapiens_hsa030500.23774031
145Measles_Homo sapiens_hsa051620.22643573
146HTLV-I infection_Homo sapiens_hsa051660.20842655
147Lysosome_Homo sapiens_hsa041420.20771673
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19319731
149Insulin resistance_Homo sapiens_hsa049310.14897288
150Galactose metabolism_Homo sapiens_hsa000520.14791077
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.13762834
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.13350108
153Arachidonic acid metabolism_Homo sapiens_hsa005900.12359454
154Vitamin B6 metabolism_Homo sapiens_hsa007500.10100430
155Gastric acid secretion_Homo sapiens_hsa049710.05709790
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05151262
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02288130
158Glucagon signaling pathway_Homo sapiens_hsa049220.01433335
159Parkinsons disease_Homo sapiens_hsa050120.01191747
160AMPK signaling pathway_Homo sapiens_hsa041520.00061754
161Fatty acid biosynthesis_Homo sapiens_hsa00061-0.1354091
162Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.1332269
163Choline metabolism in cancer_Homo sapiens_hsa05231-0.0972620
164Hepatitis C_Homo sapiens_hsa05160-0.0909536
165Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0847751
166Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0662139
167Regulation of autophagy_Homo sapiens_hsa04140-0.0516650
168Vibrio cholerae infection_Homo sapiens_hsa05110-0.0460506
169Bladder cancer_Homo sapiens_hsa05219-0.0363539

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