SLC50A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.41730891
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57211296
3signal peptide processing (GO:0006465)5.22185536
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.00246435
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00246435
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.77868135
7cotranslational protein targeting to membrane (GO:0006613)4.72250951
8protein targeting to ER (GO:0045047)4.68209006
9response to interferon-beta (GO:0035456)4.65695921
10positive regulation of gamma-delta T cell activation (GO:0046645)4.59267942
11viral transcription (GO:0019083)4.58388182
12protein localization to endoplasmic reticulum (GO:0070972)4.54330574
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.46999242
14antigen processing and presentation of endogenous antigen (GO:0019883)4.46316558
15antigen processing and presentation via MHC class Ib (GO:0002475)4.40835043
16translational termination (GO:0006415)4.34270973
17platelet dense granule organization (GO:0060155)4.29855434
18ribosomal small subunit biogenesis (GO:0042274)4.12581406
19negative regulation of erythrocyte differentiation (GO:0045647)3.89781153
20definitive hemopoiesis (GO:0060216)3.86312518
21rRNA modification (GO:0000154)3.80610126
22regulation of regulatory T cell differentiation (GO:0045589)3.74443969
23mature B cell differentiation involved in immune response (GO:0002313)3.71605991
24ATP synthesis coupled proton transport (GO:0015986)3.69376909
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.69376909
26translational elongation (GO:0006414)3.68769366
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.64877309
28rRNA methylation (GO:0031167)3.59705249
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.59502271
30positive regulation of B cell differentiation (GO:0045579)3.58140218
31lymph node development (GO:0048535)3.57570323
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.50682878
33water-soluble vitamin biosynthetic process (GO:0042364)3.50393284
34protein neddylation (GO:0045116)3.46149563
35proteasome assembly (GO:0043248)3.44971206
36viral life cycle (GO:0019058)3.44633672
37mast cell activation (GO:0045576)3.43967405
38cellular response to interferon-beta (GO:0035458)3.42971388
39regulation of T cell mediated cytotoxicity (GO:0001914)3.41212038
40preassembly of GPI anchor in ER membrane (GO:0016254)3.39483119
41type I interferon signaling pathway (GO:0060337)3.39154193
42cellular response to type I interferon (GO:0071357)3.39154193
43response to type I interferon (GO:0034340)3.38271342
44regulation of gamma-delta T cell differentiation (GO:0045586)3.37228128
45megakaryocyte development (GO:0035855)3.34685415
46mitochondrial respiratory chain complex assembly (GO:0033108)3.34459815
47defense response to protozoan (GO:0042832)3.31159954
48DNA deamination (GO:0045006)3.24555337
49electron transport chain (GO:0022900)3.22654094
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.20969967
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20969967
52positive regulation of prostaglandin secretion (GO:0032308)3.20140340
53respiratory chain complex IV assembly (GO:0008535)3.19632028
54protein targeting to membrane (GO:0006612)3.17818879
55dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.16465938
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16156591
57regulation of B cell differentiation (GO:0045577)3.15990370
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15620831
59response to protozoan (GO:0001562)3.14068584
60regulation of gamma-delta T cell activation (GO:0046643)3.13854438
61response to interleukin-15 (GO:0070672)3.12835929
62nucleoside transmembrane transport (GO:1901642)3.12379087
63cellular protein complex disassembly (GO:0043624)3.12338366
64endosome to melanosome transport (GO:0035646)3.11001818
65endosome to pigment granule transport (GO:0043485)3.11001818
66regulation of cellular amino acid metabolic process (GO:0006521)3.10731517
67positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10563223
68respiratory electron transport chain (GO:0022904)3.10172110
69B cell receptor signaling pathway (GO:0050853)3.06193903
70GDP-mannose metabolic process (GO:0019673)3.04999714
71cellular response to interleukin-15 (GO:0071350)3.04977836
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02699265
73cellular ketone body metabolic process (GO:0046950)2.99866228
74pseudouridine synthesis (GO:0001522)2.99548055
75regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.99501657
76phospholipid scrambling (GO:0017121)2.97199044
77mature B cell differentiation (GO:0002335)2.96547376
78maturation of SSU-rRNA (GO:0030490)2.95325899
79mannosylation (GO:0097502)2.91761348
80purine-containing compound salvage (GO:0043101)2.91155702
81positive regulation of granulocyte differentiation (GO:0030854)2.88679092
82purinergic nucleotide receptor signaling pathway (GO:0035590)2.86737986
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85741231
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85741231
85nucleotide transmembrane transport (GO:1901679)2.85528087
86GPI anchor biosynthetic process (GO:0006506)2.84307524
87regulation of interleukin-12 biosynthetic process (GO:0045075)2.84183001
88response to interferon-alpha (GO:0035455)2.83924367
89C-terminal protein lipidation (GO:0006501)2.83095439
90T cell homeostasis (GO:0043029)2.81532857
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81121428
92regulation of B cell receptor signaling pathway (GO:0050855)2.80240658
93peptidyl-histidine modification (GO:0018202)2.78624796
94regulation of respiratory burst (GO:0060263)2.78258068
95polyketide metabolic process (GO:0030638)2.78059889
96doxorubicin metabolic process (GO:0044598)2.78059889
97daunorubicin metabolic process (GO:0044597)2.78059889
98glutathione derivative metabolic process (GO:1901685)2.77868551
99glutathione derivative biosynthetic process (GO:1901687)2.77868551
100DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77736774
101negative regulation of glycoprotein biosynthetic process (GO:0010561)2.77308885
102nucleotide-sugar biosynthetic process (GO:0009226)2.76254950
103mast cell activation involved in immune response (GO:0002279)2.76205602
104mast cell degranulation (GO:0043303)2.76205602
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75186223
106organelle membrane fusion (GO:0090174)2.74870209
107mitochondrial calcium ion transport (GO:0006851)2.73222537
108regulation of T cell receptor signaling pathway (GO:0050856)2.71195689
109signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71085581
110signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71085581
111signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71085581
112indole-containing compound catabolic process (GO:0042436)2.70810632
113indolalkylamine catabolic process (GO:0046218)2.70810632
114tryptophan catabolic process (GO:0006569)2.70810632
115myeloid dendritic cell activation (GO:0001773)2.68022959
116L-methionine salvage (GO:0071267)2.67396086
117L-methionine biosynthetic process (GO:0071265)2.67396086
118amino acid salvage (GO:0043102)2.67396086
119mitotic cell cycle arrest (GO:0071850)2.66808977
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65623315
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65623315
122cytochrome complex assembly (GO:0017004)2.64627661
123translational initiation (GO:0006413)2.64597035
124autophagic vacuole fusion (GO:0000046)2.64205045
125glutathione biosynthetic process (GO:0006750)2.62886825
126ketone body metabolic process (GO:1902224)2.62405293
127lymphoid progenitor cell differentiation (GO:0002320)2.62021038
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59926348
129mucosal-associated lymphoid tissue development (GO:0048537)2.59902458
130Peyers patch development (GO:0048541)2.59902458
131diol metabolic process (GO:0034311)2.59121003
132negative regulation of nitric oxide biosynthetic process (GO:0045019)2.57896980
133protein complex disassembly (GO:0043241)2.57660268
134signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57120234
135signal transduction involved in DNA damage checkpoint (GO:0072422)2.57120234
136hydrogen ion transmembrane transport (GO:1902600)2.57024935
137secretory granule organization (GO:0033363)2.56255177
138phosphatidylinositol acyl-chain remodeling (GO:0036149)2.55233982
139establishment of protein localization to mitochondrial membrane (GO:0090151)2.54912173
140amine catabolic process (GO:0009310)2.54480599
141cellular biogenic amine catabolic process (GO:0042402)2.54480599
142ubiquinone biosynthetic process (GO:0006744)2.53052424
143negative regulation of viral entry into host cell (GO:0046597)2.52944240
144multicellular organism reproduction (GO:0032504)2.52713623
145behavioral response to nicotine (GO:0035095)2.51794824
146nucleoside diphosphate catabolic process (GO:0009134)2.51642449
147signal transduction involved in cell cycle checkpoint (GO:0072395)2.50732154
148positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.50631063
149NAD biosynthetic process (GO:0009435)2.50242835
150regulation of leukocyte mediated cytotoxicity (GO:0001910)2.50037573
151xenobiotic catabolic process (GO:0042178)2.49374657
152translation (GO:0006412)2.49020763
153purine nucleotide salvage (GO:0032261)2.48204429
154regulation of natural killer cell differentiation (GO:0032823)2.47936321
155protein complex biogenesis (GO:0070271)2.47934171
156cellular response to ATP (GO:0071318)2.47630446
157aromatic amino acid family catabolic process (GO:0009074)2.47365721
158positive regulation of defense response to virus by host (GO:0002230)2.47058212
159fucose catabolic process (GO:0019317)2.46988274
160L-fucose metabolic process (GO:0042354)2.46988274
161L-fucose catabolic process (GO:0042355)2.46988274
162proton transport (GO:0015992)2.46723486
163tRNA modification (GO:0006400)2.46665438
164interferon-gamma-mediated signaling pathway (GO:0060333)2.46589037
165fucosylation (GO:0036065)2.45631489
166regulation of isotype switching to IgG isotypes (GO:0048302)2.45493071
167GTP biosynthetic process (GO:0006183)2.45377747
168regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.44384041
169macromolecular complex disassembly (GO:0032984)2.43847052
170purine nucleoside triphosphate biosynthetic process (GO:0009145)2.43031053
1713-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.42680897
172purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.42680897
173negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.42439963
174negative regulation of ligase activity (GO:0051352)2.42439963
175regulation of prostaglandin secretion (GO:0032306)2.41670695
176sphingosine metabolic process (GO:0006670)2.40902143
177adenosine metabolic process (GO:0046085)2.40391301
178NADH dehydrogenase complex assembly (GO:0010257)2.40198765
179maturation of 5.8S rRNA (GO:0000460)2.40062243
180positive regulation of icosanoid secretion (GO:0032305)2.39988822
181hydrogen transport (GO:0006818)2.39911495
182nonribosomal peptide biosynthetic process (GO:0019184)2.39347250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.94538221
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.06436436
3SCL_19346495_ChIP-Seq_HPC-7_Human3.72048518
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45763221
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.36427552
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.31014993
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20587419
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.12979037
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.11403046
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08951340
11FLI1_20887958_ChIP-Seq_HPC-7_Mouse3.07456911
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97921118
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92493252
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83284715
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.78407487
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72577102
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.66988590
18GATA1_22025678_ChIP-Seq_K562_Human2.66279744
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.62750779
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.51644918
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47969811
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.46335901
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.44671838
24ERG_20887958_ChIP-Seq_HPC-7_Mouse2.44211286
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.41762217
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39426782
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.37782749
28* SPI1_23547873_ChIP-Seq_NB4_Human2.32775832
29EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19074629
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.15171050
31RUNX_20019798_ChIP-Seq_JUKART_Human2.14303673
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.08498697
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.07883066
34MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05976611
35HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03020773
36MYB_26560356_Chip-Seq_TH2_Human2.02370890
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02333385
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98506958
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.89066697
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88355740
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.88257142
42VDR_23849224_ChIP-Seq_CD4+_Human1.85183291
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84867503
44KDM5A_27292631_Chip-Seq_BREAST_Human1.78067071
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.74326313
46VDR_21846776_ChIP-Seq_THP-1_Human1.73834897
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73816917
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73737913
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72689294
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72255161
51GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.71704640
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68597832
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66126442
54MAF_26560356_Chip-Seq_TH1_Human1.65804384
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.64725587
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.63840112
57VDR_24763502_ChIP-Seq_THP-1_Human1.63551432
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63070917
59MYB_26560356_Chip-Seq_TH1_Human1.62672114
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.62357315
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.59535652
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56763125
63* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56459209
64FOXP3_21729870_ChIP-Seq_TREG_Human1.56236328
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53070704
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52674240
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51857601
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.50105946
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49857792
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.48640814
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47399892
72E2F1_20622854_ChIP-Seq_HELA_Human1.46178989
73BCL6_27268052_Chip-Seq_Bcells_Human1.43993730
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43757757
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37914235
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37840693
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35491349
78VDR_22108803_ChIP-Seq_LS180_Human1.35141129
79BCOR_27268052_Chip-Seq_Bcells_Human1.34380305
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33977906
81P300_27268052_Chip-Seq_Bcells_Human1.33691219
82UTX_26944678_Chip-Seq_JUKART_Human1.33553548
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.33182816
84STAT1_20625510_ChIP-Seq_HELA_Human1.32231191
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31653820
86NANOG_20526341_ChIP-Seq_ESCs_Human1.31354165
87ELK1_19687146_ChIP-ChIP_HELA_Human1.31237541
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.30129212
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29996747
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29819541
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28569252
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27951811
93ELF5_23300383_ChIP-Seq_T47D_Human1.25462931
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.23032807
95PHF8_20622854_ChIP-Seq_HELA_Human1.22822908
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.22668847
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21179508
98ERA_21632823_ChIP-Seq_H3396_Human1.20861116
99P68_20966046_ChIP-Seq_HELA_Human1.20094413
100AR_20517297_ChIP-Seq_VCAP_Human1.19583497
101GATA3_26560356_Chip-Seq_TH2_Human1.19376190
102MYC_22102868_ChIP-Seq_BL_Human1.19053801
103GATA3_27048872_Chip-Seq_THYMUS_Human1.18306616
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17717809
105YY1_21170310_ChIP-Seq_MESCs_Mouse1.16382757
106RXR_22158963_ChIP-Seq_LIVER_Mouse1.16348283
107SPI1_23127762_ChIP-Seq_K562_Human1.15983751
108ZNF274_21170338_ChIP-Seq_K562_Hela1.15209329
109ELF1_20517297_ChIP-Seq_JURKAT_Human1.14699553
110CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14508297
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13898741
112E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13806034
113P53_21459846_ChIP-Seq_SAOS-2_Human1.13802541
114GATA4_25053715_ChIP-Seq_YYC3_Human1.13515353
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13388159
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.13388159
117TAF2_19829295_ChIP-Seq_ESCs_Human1.12857604
118ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12112066
119TP53_22573176_ChIP-Seq_HFKS_Human1.10901591
120FOXP1_21924763_ChIP-Seq_HESCs_Human1.10724080
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10151265
122CTCF_20526341_ChIP-Seq_ESCs_Human1.09868406
123ELK1_22589737_ChIP-Seq_MCF10A_Human1.09794121
124MAF_26560356_Chip-Seq_TH2_Human1.09441257
125MYC_18940864_ChIP-ChIP_HL60_Human1.09058717
126CIITA_25753668_ChIP-Seq_RAJI_Human1.08804296
127PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08276017
128IRF1_19129219_ChIP-ChIP_H3396_Human1.07765432
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07427407
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07248864
131RARB_24833708_ChIP-Seq_LIVER_Mouse1.06486706
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06120179
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05222449
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04592242
135SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04089066
136HOXB7_26014856_ChIP-Seq_BT474_Human1.03731302
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02092187
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01900936
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01430481
140GATA6_25053715_ChIP-Seq_YYC3_Human1.01105778
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00798188
142ETS1_22383799_ChIP-Seq_G1ME_Mouse0.99761362
143CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99729139
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.99443109
145TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98119740
146CTCF_26484167_Chip-Seq_Bcells_Mouse0.97915776
147DCP1A_22483619_ChIP-Seq_HELA_Human0.97715716
148XRN2_22483619_ChIP-Seq_HELA_Human0.97516820
149SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97172879
150CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96888110
151BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95592917
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94256897
153HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93110274
154GABP_19822575_ChIP-Seq_HepG2_Human0.90525920
155CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89235447
156PU_27001747_Chip-Seq_BMDM_Mouse0.88546992
157EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83494793
158TTF2_22483619_ChIP-Seq_HELA_Human0.81671249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.27366999
2MP0001835_abnormal_antigen_presentation3.77262114
3MP0005671_abnormal_response_to3.65864821
4MP0003724_increased_susceptibility_to3.40171420
5MP0008875_abnormal_xenobiotic_pharmacok3.26070926
6MP0000685_abnormal_immune_system3.08060926
7MP0009785_altered_susceptibility_to3.05045221
8MP0005083_abnormal_biliary_tract3.00787089
9MP0002396_abnormal_hematopoietic_system2.86777673
10MP0003763_abnormal_thymus_physiology2.86399547
11MP0003195_calcinosis2.71086625
12MP0002148_abnormal_hypersensitivity_rea2.60880135
13MP0001790_abnormal_immune_system2.53216046
14MP0005387_immune_system_phenotype2.53216046
15MP0002166_altered_tumor_susceptibility2.52778019
16MP0001800_abnormal_humoral_immune2.50723591
17MP0005000_abnormal_immune_tolerance2.49753878
18MP0005025_abnormal_response_to2.43976460
19MP0002723_abnormal_immune_serum2.41195199
20MP0002420_abnormal_adaptive_immunity2.37580871
21MP0001819_abnormal_immune_cell2.32521695
22MP0002452_abnormal_antigen_presenting2.31077075
23MP0002254_reproductive_system_inflammat2.24473056
24MP0005075_abnormal_melanosome_morpholog2.21193997
25MP0009379_abnormal_foot_pigmentation2.16827681
26MP0002139_abnormal_hepatobiliary_system2.15574495
27MP0004147_increased_porphyrin_level2.13334830
28MP0003866_abnormal_defecation2.10889856
29MP0003011_delayed_dark_adaptation2.09497173
30MP0002398_abnormal_bone_marrow2.09139401
31MP0005332_abnormal_amino_acid2.08407857
32MP0001873_stomach_inflammation2.02814101
33MP0006054_spinal_hemorrhage1.99451920
34MP0005365_abnormal_bile_salt1.99043957
35MP0002419_abnormal_innate_immunity1.97259779
36MP0005464_abnormal_platelet_physiology1.96804567
37MP0010155_abnormal_intestine_physiology1.95889965
38MP0000465_gastrointestinal_hemorrhage1.95768621
39MP0009333_abnormal_splenocyte_physiolog1.94880512
40MP0003436_decreased_susceptibility_to1.94740910
41MP0000716_abnormal_immune_system1.91925026
42MP0002876_abnormal_thyroid_physiology1.90048921
43MP0004019_abnormal_vitamin_homeostasis1.88639414
44MP0005410_abnormal_fertilization1.88520700
45MP0009840_abnormal_foam_cell1.88147637
46MP0001986_abnormal_taste_sensitivity1.85446982
47MP0003718_maternal_effect1.82215340
48MP0008872_abnormal_physiological_respon1.78895487
49MP0000689_abnormal_spleen_morphology1.77058282
50MP0005174_abnormal_tail_pigmentation1.75515212
51MP0002006_tumorigenesis1.72346418
52MP0003693_abnormal_embryo_hatching1.70451675
53MP0001756_abnormal_urination1.69126310
54MP0004808_abnormal_hematopoietic_stem1.69073573
55MP0002933_joint_inflammation1.67227705
56MP0002429_abnormal_blood_cell1.66443274
57MP0002722_abnormal_immune_system1.63563543
58MP0003136_yellow_coat_color1.61850176
59MP0001764_abnormal_homeostasis1.57101504
60MP0001881_abnormal_mammary_gland1.55613202
61MP0002009_preneoplasia1.55561781
62MP0001919_abnormal_reproductive_system1.51532630
63MP0001845_abnormal_inflammatory_respons1.50991761
64MP0002405_respiratory_system_inflammati1.50965791
65MP0003183_abnormal_peptide_metabolism1.50366919
66MP0005084_abnormal_gallbladder_morpholo1.48391813
67MP0000490_abnormal_crypts_of1.48356581
68MP0005409_darkened_coat_color1.45358317
69MP0003786_premature_aging1.45063418
70MP0001879_abnormal_lymphatic_vessel1.44928910
71MP0002095_abnormal_skin_pigmentation1.44282529
72MP0005085_abnormal_gallbladder_physiolo1.37971220
73MP0001853_heart_inflammation1.37517607
74MP0005397_hematopoietic_system_phenotyp1.36001771
75MP0001545_abnormal_hematopoietic_system1.36001771
76MP0002736_abnormal_nociception_after1.35417382
77MP0005646_abnormal_pituitary_gland1.34307317
78MP0010329_abnormal_lipoprotein_level1.34031876
79MP0002132_abnormal_respiratory_system1.33043674
80MP0006082_CNS_inflammation1.31618775
81MP0005058_abnormal_lysosome_morphology1.31102947
82MP0002138_abnormal_hepatobiliary_system1.30436046
83MP0005645_abnormal_hypothalamus_physiol1.29952851
84MP0001765_abnormal_ion_homeostasis1.29777436
85MP0002837_dystrophic_cardiac_calcinosis1.28197215
86MP0008469_abnormal_protein_level1.28141684
87MP0001968_abnormal_touch/_nociception1.27589643
88MP0001533_abnormal_skeleton_physiology1.26863570
89MP0001661_extended_life_span1.26007661
90MP0000681_abnormal_thyroid_gland1.24765007
91MP0000703_abnormal_thymus_morphology1.23126459
92MP0000538_abnormal_urinary_bladder1.20147152
93MP0005551_abnormal_eye_electrophysiolog1.19347100
94MP0005389_reproductive_system_phenotype1.18791035
95MP0002693_abnormal_pancreas_physiology1.15709201
96MP0002160_abnormal_reproductive_system1.15593639
97MP0000372_irregular_coat_pigmentation1.13866600
98MP0001666_abnormal_nutrient_absorption1.12875239
99MP0008058_abnormal_DNA_repair1.12433769
100MP0000015_abnormal_ear_pigmentation1.10701054
101MP0000678_abnormal_parathyroid_gland1.08573017
102MP0005310_abnormal_salivary_gland1.05244881
103MP0000358_abnormal_cell_content/1.04860607
104MP0006035_abnormal_mitochondrial_morpho1.04860532
105MP0003638_abnormal_response/metabolism_1.04707400
106MP0004381_abnormal_hair_follicle1.03587518
107MP0003943_abnormal_hepatobiliary_system1.03429345
108MP0005319_abnormal_enzyme/_coenzyme1.03120047
109MP0010368_abnormal_lymphatic_system1.02799565
110MP0006072_abnormal_retinal_apoptosis1.00720839
111MP0001905_abnormal_dopamine_level0.99431424
112MP0005584_abnormal_enzyme/coenzyme_acti0.99145514
113MP0000230_abnormal_systemic_arterial0.97933870
114MP0004947_skin_inflammation0.97368261
115MP0001851_eye_inflammation0.95421390
116MP0003186_abnormal_redox_activity0.93237944
117MP0006036_abnormal_mitochondrial_physio0.93145376
118MP0002909_abnormal_adrenal_gland0.92200308
119MP0002118_abnormal_lipid_homeostasis0.91936949
120MP0003279_aneurysm0.90126909
121MP0005501_abnormal_skin_physiology0.90044706
122MP0002277_abnormal_respiratory_mucosa0.88388923
123MP0000609_abnormal_liver_physiology0.88080980
124MP0005647_abnormal_sex_gland0.88068554
125MP0005379_endocrine/exocrine_gland_phen0.86953557
126MP0005360_urolithiasis0.86437629
127MP0000343_altered_response_to0.85156270
128MP0006292_abnormal_olfactory_placode0.84845614
129MP0002136_abnormal_kidney_physiology0.83497751
130MP0002877_abnormal_melanocyte_morpholog0.83268636
131MP0001664_abnormal_digestion0.81854321
132MP0003656_abnormal_erythrocyte_physiolo0.80725723
133MP0009642_abnormal_blood_homeostasis0.80038971
134MP0001188_hyperpigmentation0.79596615
135MP0000613_abnormal_salivary_gland0.78733452
136MP0000427_abnormal_hair_cycle0.78704632
137MP0001944_abnormal_pancreas_morphology0.77486823
138MP0005220_abnormal_exocrine_pancreas0.76598933
139MP0003172_abnormal_lysosome_physiology0.76421234
140MP0005171_absent_coat_pigmentation0.76376190
141MP0001663_abnormal_digestive_system0.75664722
142MP0000013_abnormal_adipose_tissue0.75622757
143MP0002163_abnormal_gland_morphology0.75023873
144MP0009697_abnormal_copulation0.74281894
145MP0003300_gastrointestinal_ulcer0.73924686
146MP0000920_abnormal_myelination0.72401541
147MP0005390_skeleton_phenotype0.71963714
148MP0008004_abnormal_stomach_pH0.68221349
149MP0003828_pulmonary_edema0.67504655
150MP0005636_abnormal_mineral_homeostasis0.66183742
151MP0009764_decreased_sensitivity_to0.65989207
152MP0010386_abnormal_urinary_bladder0.65222311
153MP0003795_abnormal_bone_structure0.64674818
154MP0004043_abnormal_pH_regulation0.64162866
155MP0002998_abnormal_bone_remodeling0.60539087
156MP0000249_abnormal_blood_vessel0.60412939
157MP0004782_abnormal_surfactant_physiolog0.58907331
158MP0009643_abnormal_urine_homeostasis0.58430097

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.52486893
2Chronic otitis media (HP:0000389)4.50765419
3Thrombocytosis (HP:0001894)4.35899322
4Elevated erythrocyte sedimentation rate (HP:0003565)4.34474055
5Type I transferrin isoform profile (HP:0003642)4.26894406
6Abnormality of cells of the erythroid lineage (HP:0012130)4.05062969
7Abnormal number of erythroid precursors (HP:0012131)3.93753013
8Aplastic anemia (HP:0001915)3.91324112
9Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.82157076
10Abnormal protein N-linked glycosylation (HP:0012347)3.82157076
11Abnormal protein glycosylation (HP:0012346)3.82157076
12Abnormal glycosylation (HP:0012345)3.82157076
13Agammaglobulinemia (HP:0004432)3.70259655
14Reduced antithrombin III activity (HP:0001976)3.59217303
15Recurrent bronchitis (HP:0002837)3.58367274
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.50398524
17Abnormality of alanine metabolism (HP:0010916)3.50398524
18Hyperalaninemia (HP:0003348)3.50398524
19Vacuolated lymphocytes (HP:0001922)3.47254492
20Hypothermia (HP:0002045)3.32024744
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.27405303
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.27405303
23Lipid accumulation in hepatocytes (HP:0006561)3.25439515
24Testicular atrophy (HP:0000029)3.24074134
25Increased CSF lactate (HP:0002490)3.19372527
26Congenital stationary night blindness (HP:0007642)3.13964496
27Acute encephalopathy (HP:0006846)3.11792044
28Myositis (HP:0100614)3.11185020
29Petechiae (HP:0000967)3.11104485
30Abnormality of T cell physiology (HP:0011840)3.10816228
31Panhypogammaglobulinemia (HP:0003139)3.02062860
32Abnormal mitochondria in muscle tissue (HP:0008316)2.99742881
33Reticulocytopenia (HP:0001896)2.96979513
34Hepatocellular necrosis (HP:0001404)2.93230285
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.92642373
36Prolonged bleeding time (HP:0003010)2.90512738
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.85713469
38Recurrent abscess formation (HP:0002722)2.85599001
39Abnormality of T cells (HP:0002843)2.84168855
40Recurrent viral infections (HP:0004429)2.76336849
41Cellulitis (HP:0100658)2.72944778
42B lymphocytopenia (HP:0010976)2.72505169
43Abnormality of B cell number (HP:0010975)2.72505169
44Attenuation of retinal blood vessels (HP:0007843)2.71985402
45Hepatic necrosis (HP:0002605)2.70046850
46Gastrointestinal stroma tumor (HP:0100723)2.69692500
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.61508736
48Purpura (HP:0000979)2.61346516
49Progressive macrocephaly (HP:0004481)2.59591904
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59031086
51Increased serum lactate (HP:0002151)2.57029039
52IgG deficiency (HP:0004315)2.56188566
53Meningitis (HP:0001287)2.54174508
54Recurrent bacterial skin infections (HP:0005406)2.48413856
55Abnormality of macrophages (HP:0004311)2.46831337
56Hypoproteinemia (HP:0003075)2.44879139
57Lethargy (HP:0001254)2.44699118
58Hypoplasia of the pons (HP:0012110)2.43680345
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42031089
60T lymphocytopenia (HP:0005403)2.41806979
61Congenital, generalized hypertrichosis (HP:0004540)2.41621421
62Mitochondrial inheritance (HP:0001427)2.40773321
63Methylmalonic aciduria (HP:0012120)2.40115711
64Abnormality of the pons (HP:0007361)2.39779994
65Epistaxis (HP:0000421)2.38943775
66Pallor (HP:0000980)2.38860184
67Lactic acidosis (HP:0003128)2.38465404
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37008757
69Dicarboxylic aciduria (HP:0003215)2.37008757
70Erythema (HP:0010783)2.36269274
71Fatigue (HP:0012378)2.35988849
72Inflammation of the large intestine (HP:0002037)2.33171811
73Abnormality of the nasal mucosa (HP:0000433)2.33075095
74Abnormality of T cell number (HP:0011839)2.32184808
75Lymphopenia (HP:0001888)2.31380202
76Mesangial abnormality (HP:0001966)2.31278841
77Interstitial pulmonary disease (HP:0006530)2.31207337
78Glycosuria (HP:0003076)2.30968581
79Abnormality of urine glucose concentration (HP:0011016)2.30968581
80Pancreatic cysts (HP:0001737)2.30815202
81Neutropenia (HP:0001875)2.30578287
82Ketoacidosis (HP:0001993)2.30222389
83Chronic sinusitis (HP:0011109)2.30167698
84Type 2 muscle fiber atrophy (HP:0003554)2.26657539
85Beaking of vertebral bodies (HP:0004568)2.25936249
86Gastrointestinal inflammation (HP:0004386)2.25878123
87Microretrognathia (HP:0000308)2.25341265
88Patchy hypopigmentation of hair (HP:0011365)2.24330383
89Abnormality of the renal cortex (HP:0011035)2.23629299
90Renal Fanconi syndrome (HP:0001994)2.23610127
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22933088
92Cerebral edema (HP:0002181)2.22211769
93Dyschromatopsia (HP:0007641)2.21728586
943-Methylglutaconic aciduria (HP:0003535)2.21704709
95Molar tooth sign on MRI (HP:0002419)2.21351215
96Abnormality of midbrain morphology (HP:0002418)2.21351215
97Progressive neurologic deterioration (HP:0002344)2.20415986
98Abnormality of renal resorption (HP:0011038)2.16590992
99Nausea (HP:0002018)2.16343201
100Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16284337
101Increased neuronal autofluorescent lipopigment (HP:0002074)2.16121345
102Ketosis (HP:0001946)2.15330564
103Abnormality of cells of the lymphoid lineage (HP:0012140)2.15196904
104Microcytic anemia (HP:0001935)2.14609462
105Spontaneous hematomas (HP:0007420)2.14574396
106Muscle fiber atrophy (HP:0100295)2.14225684
107Recurrent fungal infections (HP:0002841)2.13509306
108Increased intramyocellular lipid droplets (HP:0012240)2.12748829
109Recurrent skin infections (HP:0001581)2.12467243
110Chronic diarrhea (HP:0002028)2.11198741
111Abolished electroretinogram (ERG) (HP:0000550)2.09234758
112Optic disc pallor (HP:0000543)2.07961866
113Tubular atrophy (HP:0000092)2.06054330
114Methylmalonic acidemia (HP:0002912)2.04548935
115Vasculitis (HP:0002633)2.03497087
116Nonprogressive disorder (HP:0003680)2.02788912
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01914064
118Hypergammaglobulinemia (HP:0010702)2.01835165
119Increased muscle lipid content (HP:0009058)2.00914061
120Macrocytic anemia (HP:0001972)2.00781144
121Hypoalbuminemia (HP:0003073)2.00306430
122Abnormal albumin level (HP:0012116)2.00306430
123Absent thumb (HP:0009777)1.98994663
124Pancytopenia (HP:0001876)1.98900945
125Increased IgE level (HP:0003212)1.98662564
126Vertebral compression fractures (HP:0002953)1.98343745
127Large for gestational age (HP:0001520)1.98256253
128Nasal polyposis (HP:0100582)1.97452099
129Exertional dyspnea (HP:0002875)1.97075683
130Bronchitis (HP:0012387)1.96912461
131Increased hepatocellular lipid droplets (HP:0006565)1.94985143
132Thyroiditis (HP:0100646)1.94229288
133Concave nail (HP:0001598)1.93542548
134Respiratory failure (HP:0002878)1.92832350
135Pendular nystagmus (HP:0012043)1.92828954
136Abnormality of liposaccharide metabolism (HP:0010968)1.91845288
137Abnormality of glycosphingolipid metabolism (HP:0004343)1.91845288
138Abnormality of glycolipid metabolism (HP:0010969)1.91845288
139Generalized aminoaciduria (HP:0002909)1.91484299
140Abnormality of serum amino acid levels (HP:0003112)1.91388639
141Abnormality of fatty-acid metabolism (HP:0004359)1.91163487
142White forelock (HP:0002211)1.90841431
14311 pairs of ribs (HP:0000878)1.89581416
144Type II lissencephaly (HP:0007260)1.88764798
145Dysostosis multiplex (HP:0000943)1.88710643
146Acute necrotizing encephalopathy (HP:0006965)1.87531619
147Broad face (HP:0000283)1.86184812
148Episodic fever (HP:0001954)1.86145173
149Chronic mucocutaneous candidiasis (HP:0002728)1.86076095
150Recurrent cutaneous fungal infections (HP:0011370)1.86076095
151Severe combined immunodeficiency (HP:0004430)1.85711601
152Eczematoid dermatitis (HP:0000976)1.85707782
153Epiphyseal stippling (HP:0010655)1.85432592
154Hypophosphatemic rickets (HP:0004912)1.81615720
155Aplasia/hypoplasia of the uterus (HP:0008684)1.81036674
156Hyperammonemia (HP:0001987)1.80868279
157Opisthotonus (HP:0002179)1.80197034
158Renal cortical cysts (HP:0000803)1.77436462
159Decreased central vision (HP:0007663)1.76540734
160Alkalosis (HP:0001948)1.76351403
161Conjunctival hamartoma (HP:0100780)1.76153341
162Progressive microcephaly (HP:0000253)1.75617406
163Abnormality of transition element cation homeostasis (HP:0011030)1.74473867
164Tinnitus (HP:0000360)1.74358341
165Abnormality of vitamin B metabolism (HP:0004340)1.73127243
166Pancreatic fibrosis (HP:0100732)1.72220865
167Exercise intolerance (HP:0003546)1.71909131
168Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71346428
169Metabolic acidosis (HP:0001942)1.70896632
170Brushfield spots (HP:0001088)1.70674223
171Decreased circulating renin level (HP:0003351)1.70469878
172Abnormal biliary tract physiology (HP:0012439)1.70274650
173Bile duct proliferation (HP:0001408)1.70274650
174Birth length less than 3rd percentile (HP:0003561)1.69513383
175Rib fusion (HP:0000902)1.68970247

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.56586302
2MAP4K13.54838866
3VRK23.40947200
4TNIK2.80602659
5NME22.80165338
6FRK2.73808114
7MAP3K122.69992545
8KIT2.67252075
9TXK2.57065671
10WNK42.52617936
11TEC2.48550304
12CDK192.35271778
13FLT32.29758328
14BTK2.28894084
15NLK2.20724857
16EPHA22.17042099
17MUSK2.12677962
18ZAP702.06551321
19IRAK42.04320895
20IKBKE1.99337012
21GRK11.98726727
22MAPKAPK51.94523764
23STK161.93909644
24MYLK1.88547443
25TIE11.86905833
26TBK11.86632498
27MAP3K141.79328905
28MST41.78822746
29JAK31.78476044
30NUAK11.72664431
31EIF2AK11.70765158
32KDR1.68392965
33PIM21.66683791
34ERN11.65255825
35BCKDK1.60515329
36TGFBR21.59290520
37MAPK151.55161394
38SYK1.54809919
39ADRBK21.52144730
40NME11.42876085
41CSF1R1.42010290
42TESK21.36877882
43TYK21.36619684
44MST1R1.35836131
45MAP2K31.35536733
46CAMKK21.30279534
47ITK1.26972912
48TGFBR11.23163432
49IKBKB1.22164091
50TNK21.21613502
51LCK1.18627482
52VRK11.17710065
53EIF2AK31.15939139
54IRAK31.15733703
55PRKCI1.13328682
56BLK1.09730289
57LYN1.08876857
58HIPK21.07405860
59PRKG21.01879630
60ADRBK11.00495226
61BUB10.97308418
62MAP4K20.96916601
63STK390.94169428
64MAP3K130.92355735
65BMPR20.91869443
66CLK10.89506550
67FES0.87736635
68RPS6KB20.87358667
69PASK0.87260332
70JAK10.82905818
71MATK0.81427412
72PBK0.81252560
73TRIM280.80526394
74PINK10.79848387
75FER0.79209503
76LRRK20.79142112
77EPHB10.77442344
78PDK20.75076792
79GRK60.69796503
80ABL20.68697729
81CSNK1G30.68676264
82OXSR10.67536350
83TAF10.66884330
84MARK30.66439483
85CAMK10.66286928
86INSRR0.66029433
87WNK30.65233895
88PIK3CA0.64140898
89NEK10.64011709
90MAPKAPK30.63811942
91EPHA30.61784375
92MAP2K60.60939994
93BMX0.60372774
94RPS6KA40.59226616
95MAP3K110.58698963
96SIK30.58476798
97MET0.58143125
98RIPK40.58034518
99PIK3CG0.56894962
100HCK0.56737892
101PLK30.53486575
102TSSK60.53055216
103ILK0.51701630
104IRAK10.50835639
105BRSK20.50601002
106TAOK30.50172236
107MAPK110.49231356
108TRPM70.49063424
109BMPR1B0.48598069
110ACVR1B0.48544352
111RPS6KA50.47966965
112RPS6KA60.46983883
113CHUK0.46301108
114CSNK1G10.45919666
115PIM10.45707219
116MAP2K10.45218490
117ARAF0.44965453
118WEE10.44076329
119PRKD20.43049237
120MKNK10.42041332
121MAP2K20.42037654
122DYRK20.41543216
123PRKCQ0.41255501
124LIMK10.39479798
125MAP3K10.39439612
126CDK80.38737821
127PTK2B0.37911145
128MAPK40.37793203
129PHKG20.37405446
130PHKG10.37405446
131DAPK10.36742982
132MAP3K30.35859552
133CSNK1A1L0.35175060
134GRK70.35146277
135MAPK120.34478895
136STK100.34216374
137CSNK2A10.34188283
138DAPK30.33807379
139PRKCD0.33139376
140NEK60.32297441
141MAPK30.31950628
142PAK10.31922144
143TLK10.31031384
144RPS6KC10.30940775
145RPS6KL10.30940775
146CSK0.30318648

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.88835973
2Ribosome_Homo sapiens_hsa030104.26239862
3Primary immunodeficiency_Homo sapiens_hsa053403.45470779
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.70737056
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.44724654
6SNARE interactions in vesicular transport_Homo sapiens_hsa041302.20248663
7Other glycan degradation_Homo sapiens_hsa005112.08755036
8Hematopoietic cell lineage_Homo sapiens_hsa046401.81568057
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.81436026
10Nitrogen metabolism_Homo sapiens_hsa009101.80461849
11N-Glycan biosynthesis_Homo sapiens_hsa005101.78964880
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77032002
13DNA replication_Homo sapiens_hsa030301.73209370
14Folate biosynthesis_Homo sapiens_hsa007901.73010510
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72420931
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70224110
17Proteasome_Homo sapiens_hsa030501.67226409
18One carbon pool by folate_Homo sapiens_hsa006701.65925997
19Selenocompound metabolism_Homo sapiens_hsa004501.64702312
20Antigen processing and presentation_Homo sapiens_hsa046121.64650684
21B cell receptor signaling pathway_Homo sapiens_hsa046621.63334586
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63107583
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60409587
24Base excision repair_Homo sapiens_hsa034101.56642690
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.55528992
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52863429
27Leishmaniasis_Homo sapiens_hsa051401.50164785
28Linoleic acid metabolism_Homo sapiens_hsa005911.48061407
29Measles_Homo sapiens_hsa051621.47103649
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.46806676
31Sulfur metabolism_Homo sapiens_hsa009201.44725486
32Oxidative phosphorylation_Homo sapiens_hsa001901.44535199
33Peroxisome_Homo sapiens_hsa041461.40141667
34Glutathione metabolism_Homo sapiens_hsa004801.37922193
35Pyrimidine metabolism_Homo sapiens_hsa002401.36624073
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34823440
37Allograft rejection_Homo sapiens_hsa053301.33412182
38Chemical carcinogenesis_Homo sapiens_hsa052041.33372057
39Parkinsons disease_Homo sapiens_hsa050121.32608684
40RNA polymerase_Homo sapiens_hsa030201.27348785
41Tryptophan metabolism_Homo sapiens_hsa003801.25542373
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24759316
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23632283
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23147949
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21865226
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19566574
47Homologous recombination_Homo sapiens_hsa034401.16590807
48Fructose and mannose metabolism_Homo sapiens_hsa000511.15681694
49Mismatch repair_Homo sapiens_hsa034301.14666300
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.14390541
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.13158877
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12903489
53Caffeine metabolism_Homo sapiens_hsa002321.11912075
54Vitamin digestion and absorption_Homo sapiens_hsa049771.11282883
55Malaria_Homo sapiens_hsa051441.11247742
56Herpes simplex infection_Homo sapiens_hsa051681.07619768
57Butanoate metabolism_Homo sapiens_hsa006501.07586243
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06755756
59Cyanoamino acid metabolism_Homo sapiens_hsa004601.05599543
60Shigellosis_Homo sapiens_hsa051311.01927886
61Rheumatoid arthritis_Homo sapiens_hsa053231.01526312
62Osteoclast differentiation_Homo sapiens_hsa043801.00958581
63Non-homologous end-joining_Homo sapiens_hsa034501.00520598
64Platelet activation_Homo sapiens_hsa046111.00356903
65Pertussis_Homo sapiens_hsa051331.00029275
66Fatty acid elongation_Homo sapiens_hsa000620.98523645
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.96966252
68Fat digestion and absorption_Homo sapiens_hsa049750.96864311
69Alzheimers disease_Homo sapiens_hsa050100.96658730
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96059820
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95097640
72Basal transcription factors_Homo sapiens_hsa030220.94155985
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93630174
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.93593254
75T cell receptor signaling pathway_Homo sapiens_hsa046600.91574743
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89919140
77Ether lipid metabolism_Homo sapiens_hsa005650.89750810
78Lysosome_Homo sapiens_hsa041420.88733088
79Fanconi anemia pathway_Homo sapiens_hsa034600.88564953
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88405399
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85820928
82Mineral absorption_Homo sapiens_hsa049780.85419018
83Purine metabolism_Homo sapiens_hsa002300.84977173
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84708746
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84197734
86Phototransduction_Homo sapiens_hsa047440.83474255
87Retinol metabolism_Homo sapiens_hsa008300.81909753
88Regulation of autophagy_Homo sapiens_hsa041400.81803051
89Legionellosis_Homo sapiens_hsa051340.80721771
90Collecting duct acid secretion_Homo sapiens_hsa049660.80671922
91Galactose metabolism_Homo sapiens_hsa000520.80225226
92Sulfur relay system_Homo sapiens_hsa041220.79510689
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79298151
94Vibrio cholerae infection_Homo sapiens_hsa051100.78110073
95Graft-versus-host disease_Homo sapiens_hsa053320.77942688
96Sphingolipid metabolism_Homo sapiens_hsa006000.77491512
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77261850
98Arachidonic acid metabolism_Homo sapiens_hsa005900.76997539
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.76807053
100Nucleotide excision repair_Homo sapiens_hsa034200.71348258
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71327807
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70309556
103Autoimmune thyroid disease_Homo sapiens_hsa053200.69850649
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69715422
105Acute myeloid leukemia_Homo sapiens_hsa052210.69692418
106Propanoate metabolism_Homo sapiens_hsa006400.69646182
107Steroid biosynthesis_Homo sapiens_hsa001000.69395027
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67178202
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65380779
110Influenza A_Homo sapiens_hsa051640.64658072
111Fatty acid metabolism_Homo sapiens_hsa012120.64350467
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.64222468
113Fatty acid degradation_Homo sapiens_hsa000710.62572292
114Spliceosome_Homo sapiens_hsa030400.60348762
115Toxoplasmosis_Homo sapiens_hsa051450.59524706
116Type I diabetes mellitus_Homo sapiens_hsa049400.58697458
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58123170
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57894626
119RNA degradation_Homo sapiens_hsa030180.55978119
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55475587
121beta-Alanine metabolism_Homo sapiens_hsa004100.54848319
122Hepatitis B_Homo sapiens_hsa051610.54688013
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54629046
124Tuberculosis_Homo sapiens_hsa051520.54452106
125Salmonella infection_Homo sapiens_hsa051320.54109745
126Pyruvate metabolism_Homo sapiens_hsa006200.53289588
127TNF signaling pathway_Homo sapiens_hsa046680.53104364
128Tyrosine metabolism_Homo sapiens_hsa003500.53090733
129Systemic lupus erythematosus_Homo sapiens_hsa053220.51357752
130Huntingtons disease_Homo sapiens_hsa050160.50209660
131Asthma_Homo sapiens_hsa053100.49974587
132Hepatitis C_Homo sapiens_hsa051600.48281477
133Apoptosis_Homo sapiens_hsa042100.46543039
134Glycerolipid metabolism_Homo sapiens_hsa005610.45820658
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44730585
136Thyroid cancer_Homo sapiens_hsa052160.40834336
137Pancreatic secretion_Homo sapiens_hsa049720.39979520
138African trypanosomiasis_Homo sapiens_hsa051430.39782286
139Chemokine signaling pathway_Homo sapiens_hsa040620.39357586
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.37061616
141Epstein-Barr virus infection_Homo sapiens_hsa051690.34781763
142Phagosome_Homo sapiens_hsa041450.33230844
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33163082
144Metabolic pathways_Homo sapiens_hsa011000.30588521
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28677045
146ABC transporters_Homo sapiens_hsa020100.26388630

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