SLC51A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.37719759
2angiotensin maturation (GO:0002003)7.46131801
3intestinal cholesterol absorption (GO:0030299)7.21547876
4drug catabolic process (GO:0042737)6.68064479
5drug transmembrane transport (GO:0006855)6.67442230
6regulation of bile acid biosynthetic process (GO:0070857)6.14269359
7drug transport (GO:0015893)5.86999509
8flavonoid metabolic process (GO:0009812)5.86853431
9actin filament depolymerization (GO:0030042)5.66814568
10epoxygenase P450 pathway (GO:0019373)5.60731251
11urate metabolic process (GO:0046415)5.39487731
12exogenous drug catabolic process (GO:0042738)5.37840789
13modified amino acid transport (GO:0072337)5.26485136
14regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.25883244
15* bile acid and bile salt transport (GO:0015721)5.16006839
16regulation of triglyceride catabolic process (GO:0010896)4.90533148
173-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.77357935
18purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.77357935
19sulfur compound transport (GO:0072348)4.76143322
20bundle of His cell to Purkinje myocyte communication (GO:0086069)4.68225265
21sulfate transmembrane transport (GO:1902358)4.64601129
22glucose 6-phosphate metabolic process (GO:0051156)4.60084679
23virion attachment to host cell (GO:0019062)4.59693191
24adhesion of symbiont to host cell (GO:0044650)4.59693191
25behavioral response to nicotine (GO:0035095)4.57857241
26UDP-N-acetylglucosamine metabolic process (GO:0006047)4.43794727
27alkaloid metabolic process (GO:0009820)4.38052203
28phosphate ion transport (GO:0006817)4.33160658
29indole-containing compound catabolic process (GO:0042436)4.24763634
30indolalkylamine catabolic process (GO:0046218)4.24763634
31tryptophan catabolic process (GO:0006569)4.24763634
32omega-hydroxylase P450 pathway (GO:0097267)4.22041353
33renal absorption (GO:0070293)4.18405882
34homocysteine metabolic process (GO:0050667)4.14669804
35nonribosomal peptide biosynthetic process (GO:0019184)4.10514086
36oxidative demethylation (GO:0070989)4.07881053
37organic cation transport (GO:0015695)4.04765359
38glutathione biosynthetic process (GO:0006750)4.02048151
39arginine metabolic process (GO:0006525)4.00917673
40phosphate ion transmembrane transport (GO:0035435)3.95990715
41high-density lipoprotein particle remodeling (GO:0034375)3.94093400
42peptide catabolic process (GO:0043171)3.93977363
43digestive system process (GO:0022600)3.93109690
44aminoglycoside antibiotic metabolic process (GO:0030647)3.91614727
45response to hepatocyte growth factor (GO:0035728)3.91249300
46cellular response to hepatocyte growth factor stimulus (GO:0035729)3.91249300
47sulfur amino acid catabolic process (GO:0000098)3.87077969
48indolalkylamine metabolic process (GO:0006586)3.82253004
49intestinal epithelial cell development (GO:0060576)3.82223401
50aromatic amino acid family catabolic process (GO:0009074)3.81983809
51calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.81432640
52sulfate transport (GO:0008272)3.80976562
53fructose metabolic process (GO:0006000)3.78652557
54quaternary ammonium group transport (GO:0015697)3.78307205
55oligosaccharide catabolic process (GO:0009313)3.76934237
56vitamin A metabolic process (GO:0006776)3.76897490
57ketone body metabolic process (GO:1902224)3.72341148
58vitamin transport (GO:0051180)3.71894633
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.70514720
60cysteine metabolic process (GO:0006534)3.68287359
61tryptophan metabolic process (GO:0006568)3.67471988
62phenylpropanoid metabolic process (GO:0009698)3.67001367
63cellular glucuronidation (GO:0052695)3.65756559
64glucuronate metabolic process (GO:0019585)3.61497743
65uronic acid metabolic process (GO:0006063)3.61497743
66sulfation (GO:0051923)3.61369352
67phosphate ion homeostasis (GO:0055062)3.61019579
68trivalent inorganic anion homeostasis (GO:0072506)3.61019579
69cytidine metabolic process (GO:0046087)3.60697325
70cytidine catabolic process (GO:0006216)3.60697325
71cytidine deamination (GO:0009972)3.60697325
72bile acid metabolic process (GO:0008206)3.59533786
73drug metabolic process (GO:0017144)3.57462123
74fat-soluble vitamin biosynthetic process (GO:0042362)3.57327976
75neurotransmitter biosynthetic process (GO:0042136)3.55708655
76negative regulation of cholesterol transport (GO:0032375)3.54364198
77negative regulation of sterol transport (GO:0032372)3.54364198
78maintenance of gastrointestinal epithelium (GO:0030277)3.53507106
79diacylglycerol metabolic process (GO:0046339)3.51541259
80adhesion of symbiont to host (GO:0044406)3.50456798
81lysine metabolic process (GO:0006553)3.48920975
82lysine catabolic process (GO:0006554)3.48920975
83serine family amino acid catabolic process (GO:0009071)3.48458137
84regulation of cholesterol homeostasis (GO:2000188)3.48405892
85reverse cholesterol transport (GO:0043691)3.45100821
86bicarbonate transport (GO:0015701)3.44337171
87heme transport (GO:0015886)3.39691191
88hydrogen peroxide catabolic process (GO:0042744)3.38611676
89digestion (GO:0007586)3.37548850
90kynurenine metabolic process (GO:0070189)3.35870285
91fucose catabolic process (GO:0019317)3.34105928
92L-fucose metabolic process (GO:0042354)3.34105928
93L-fucose catabolic process (GO:0042355)3.34105928
94vitamin biosynthetic process (GO:0009110)3.33964781
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.33856505
96L-phenylalanine catabolic process (GO:0006559)3.33856505
97macromolecular complex remodeling (GO:0034367)3.31162548
98plasma lipoprotein particle remodeling (GO:0034369)3.31162548
99protein-lipid complex remodeling (GO:0034368)3.31162548
100glutathione metabolic process (GO:0006749)3.29400213
101carnitine transport (GO:0015879)3.29220964
102amino-acid betaine transport (GO:0015838)3.29220964
103bile acid biosynthetic process (GO:0006699)3.28825358
104ethanol oxidation (GO:0006069)3.28361208
105regulation of guanylate cyclase activity (GO:0031282)3.28319583
106cGMP-mediated signaling (GO:0019934)3.24309763
107excretion (GO:0007588)3.22137635
108positive regulation of glycoprotein biosynthetic process (GO:0010560)3.19560037
109cellular ketone body metabolic process (GO:0046950)3.19036638
110NADH metabolic process (GO:0006734)3.17738621
111lipoprotein metabolic process (GO:0042157)3.17460249
112vitamin D metabolic process (GO:0042359)3.16976347
113positive regulation of fatty acid transport (GO:2000193)3.16099747
114O-glycan processing (GO:0016266)3.15806065
115nucleobase catabolic process (GO:0046113)3.13123465
116triglyceride homeostasis (GO:0070328)3.11433390
117acylglycerol homeostasis (GO:0055090)3.11433390
118transepithelial transport (GO:0070633)3.10693469
119peptide biosynthetic process (GO:0043043)3.10603930
120water-soluble vitamin biosynthetic process (GO:0042364)3.10601587
121antibacterial humoral response (GO:0019731)3.10395628
122phospholipid efflux (GO:0033700)3.10387169
123lipoprotein transport (GO:0042953)3.08755233
124positive regulation of glycoprotein metabolic process (GO:1903020)3.07735865
125amine catabolic process (GO:0009310)3.07541196
126cellular biogenic amine catabolic process (GO:0042402)3.07541196
127thyroid hormone metabolic process (GO:0042403)3.06046553
128aldehyde catabolic process (GO:0046185)3.04831430
129receptor guanylyl cyclase signaling pathway (GO:0007168)3.02822065
130desmosome organization (GO:0002934)3.02665485
131S-adenosylmethionine metabolic process (GO:0046500)3.00848803
132glyoxylate metabolic process (GO:0046487)3.00088227
133positive regulation of icosanoid secretion (GO:0032305)2.99922484
134antimicrobial humoral response (GO:0019730)2.99704214
135very-low-density lipoprotein particle assembly (GO:0034379)2.98308478
136hormone catabolic process (GO:0042447)2.97460128
137phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.97408406
138amino-acid betaine metabolic process (GO:0006577)2.96880318
139regulation of fibrinolysis (GO:0051917)2.95835095
140vitamin transmembrane transport (GO:0035461)2.94934912
141sterol homeostasis (GO:0055092)2.93921522
142killing of cells of other organism (GO:0031640)2.93898478
143disruption of cells of other organism (GO:0044364)2.93898478
144regulation of cholesterol esterification (GO:0010872)2.93095235
145cholesterol efflux (GO:0033344)2.92372680
146glycerol metabolic process (GO:0006071)2.91864563
147pyrimidine ribonucleoside catabolic process (GO:0046133)2.91642776
148glutathione derivative metabolic process (GO:1901685)2.90984348
149glutathione derivative biosynthetic process (GO:1901687)2.90984348
150cholesterol homeostasis (GO:0042632)2.90527655
151amino acid transmembrane transport (GO:0003333)2.89453613
152endocrine process (GO:0050886)2.89054069
153mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.88673781
154detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87111618
155pyrimidine nucleobase catabolic process (GO:0006208)2.84056632
156quinone biosynthetic process (GO:1901663)2.83124077
157epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81273692
158endocrine pancreas development (GO:0031018)2.78855559
159xenobiotic metabolic process (GO:0006805)2.76732685
160ATP synthesis coupled proton transport (GO:0015986)2.76638850
161energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76638850
162kidney morphogenesis (GO:0060993)2.74946798
163aromatic amino acid family metabolic process (GO:0009072)2.74274395
164response to pheromone (GO:0019236)2.74242911
165indole-containing compound metabolic process (GO:0042430)2.72901134
166benzene-containing compound metabolic process (GO:0042537)2.70946106
167positive regulation of lipid catabolic process (GO:0050996)2.69685686
168alanine transport (GO:0032328)2.68510520
169negative regulation of fibrinolysis (GO:0051918)2.66456995
170ethanol metabolic process (GO:0006067)2.65966203
171sequestering of actin monomers (GO:0042989)2.63436506
172positive regulation of fatty acid beta-oxidation (GO:0032000)2.63208484
173erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.62087755
174L-phenylalanine metabolic process (GO:0006558)2.62087755
175positive regulation of guanylate cyclase activity (GO:0031284)2.61508638
176alpha-amino acid catabolic process (GO:1901606)2.58776539
177epithelial cilium movement (GO:0003351)2.58343075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.76521777
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.13608535
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.66976618
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.46403131
5ZNF274_21170338_ChIP-Seq_K562_Hela3.29583497
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.29156102
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.16628227
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.14485025
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.97596649
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.93250150
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.88465063
12GATA4_25053715_ChIP-Seq_YYC3_Human2.78304645
13GATA6_25053715_ChIP-Seq_YYC3_Human2.73907551
14SOX2_20726797_ChIP-Seq_SW620_Human2.68277499
15EZH2_22144423_ChIP-Seq_EOC_Human2.56439507
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46464615
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.45818634
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43600568
19SRY_22984422_ChIP-ChIP_TESTIS_Rat2.30185815
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.25235788
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.15820077
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13881656
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13775988
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13416880
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10617244
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.06087357
27GBX2_23144817_ChIP-Seq_PC3_Human2.02123337
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91720521
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91438260
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90353433
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.89322818
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86682224
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.82748210
34IGF1R_20145208_ChIP-Seq_DFB_Human1.76621057
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72538997
36RACK7_27058665_Chip-Seq_MCF-7_Human1.72057573
37BCAT_22108803_ChIP-Seq_LS180_Human1.71425970
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.70067381
39P300_19829295_ChIP-Seq_ESCs_Human1.68141939
40ER_23166858_ChIP-Seq_MCF-7_Human1.68091575
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67400809
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.65336274
43FUS_26573619_Chip-Seq_HEK293_Human1.64279419
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60711410
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60580176
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60146723
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57873887
48TAF15_26573619_Chip-Seq_HEK293_Human1.55367764
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.52441899
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.51641246
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.51484848
52AR_21909140_ChIP-Seq_LNCAP_Human1.50064773
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47831803
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44914639
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44769946
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44149475
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.44149475
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43319493
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43064268
60KLF5_25053715_ChIP-Seq_YYC3_Human1.42617747
61IRF1_19129219_ChIP-ChIP_H3396_Human1.42466619
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42204828
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.40152114
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39885808
65CBP_20019798_ChIP-Seq_JUKART_Human1.39819455
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39819455
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39700059
68SOX2_19829295_ChIP-Seq_ESCs_Human1.38876005
69NANOG_19829295_ChIP-Seq_ESCs_Human1.38876005
70HNF4A_19822575_ChIP-Seq_HepG2_Human1.38305713
71AR_25329375_ChIP-Seq_VCAP_Human1.38156558
72AR_20517297_ChIP-Seq_VCAP_Human1.37493314
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37462918
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.37370961
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.36739261
76ATF3_27146783_Chip-Seq_COLON_Human1.36230708
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35629008
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35050187
79CLOCK_20551151_ChIP-Seq_293T_Human1.32768970
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32069519
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32005628
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.31734517
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31595123
84NCOR_22424771_ChIP-Seq_293T_Human1.31519096
85REST_21632747_ChIP-Seq_MESCs_Mouse1.31182401
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30733021
87EWS_26573619_Chip-Seq_HEK293_Human1.30636099
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29486992
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29432303
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28999824
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28981859
92GATA3_21878914_ChIP-Seq_MCF-7_Human1.28349489
93TCF4_22108803_ChIP-Seq_LS180_Human1.27723099
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27064242
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26245305
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25954158
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25412675
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25403781
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24402843
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24272924
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23995028
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23686485
103TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23186227
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22735850
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.22409107
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22127234
107GATA2_19941826_ChIP-Seq_K562_Human1.21720350
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20898519
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20884782
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20127639
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20127639
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.18605374
113TP53_22573176_ChIP-Seq_HFKS_Human1.18517080
114AR_21572438_ChIP-Seq_LNCaP_Human1.18146431
115LXR_22292898_ChIP-Seq_THP-1_Human1.18126299
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17592125
117STAT3_23295773_ChIP-Seq_U87_Human1.17009757
118EGR1_19032775_ChIP-ChIP_M12_Human1.16478893
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16379634
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16091736
121MYC_19829295_ChIP-Seq_ESCs_Human1.15805799
122VDR_22108803_ChIP-Seq_LS180_Human1.15620080
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15480519
124AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13602284
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13509072
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13216283
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.12614490
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10608388
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.08722968
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.08688814
131TCF4_23295773_ChIP-Seq_U87_Human1.08680261
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07518847
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06260947
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05926110
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05464402
136SMAD4_21799915_ChIP-Seq_A2780_Human1.04850628
137TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04664970
138CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04178678
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03432498
140RUNX2_22187159_ChIP-Seq_PCA_Human1.03165274
141MYC_18940864_ChIP-ChIP_HL60_Human1.02199274
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01780236
143NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01043023
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00368085
145ERA_21632823_ChIP-Seq_H3396_Human1.00278343
146SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00082958
147CREB1_26743006_Chip-Seq_LNCaP_Human0.99679332
148FOXA2_19822575_ChIP-Seq_HepG2_Human0.99138548
149FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98865514
150KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98805729
151RNF2_27304074_Chip-Seq_NSC_Mouse0.98746423
152EZH2_27294783_Chip-Seq_ESCs_Mouse0.98725929
153EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98572302
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98421839
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97479280
156FOXH1_21741376_ChIP-Seq_EPCs_Human0.97214574
157RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97076206
158AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96267222
159CTCF_27219007_Chip-Seq_Bcells_Human0.94112992
160OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92300570
161SMAD3_21741376_ChIP-Seq_HESCs_Human0.91251351
162TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90363249
163GATA3_24758297_ChIP-Seq_MCF-7_Human0.90322589
164MYC_19915707_ChIP-ChIP_AK7_Human0.89559682
165CDX2_22108803_ChIP-Seq_LS180_Human0.89167998
166JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86353883
167TP63_22573176_ChIP-Seq_HFKS_Human0.85235170
168HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84062251
169UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84054270
170CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83492064
171P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81638593
172SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81364887
173GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80592607
174SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78638685
175GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78257252
176RARA_24833708_ChIP-Seq_LIVER_Mouse0.77896345
177TAF2_19829295_ChIP-Seq_ESCs_Human0.77733889
178GATA1_19941826_ChIP-Seq_K562_Human0.77016472
179ZNF263_19887448_ChIP-Seq_K562_Human0.76913235
180NANOG_20526341_ChIP-Seq_ESCs_Human0.76779108
181NANOG_18692474_ChIP-Seq_MESCs_Mouse0.76038010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.24568535
2MP0010234_abnormal_vibrissa_follicle4.83686277
3MP0001666_abnormal_nutrient_absorption4.31425793
4MP0005377_hearing/vestibular/ear_phenot3.90835358
5MP0003878_abnormal_ear_physiology3.90835358
6MP0003195_calcinosis3.81042102
7MP0002139_abnormal_hepatobiliary_system3.65379904
8MP0004264_abnormal_extraembryonic_tissu3.62138577
9MP0005085_abnormal_gallbladder_physiolo3.50736021
10MP0004019_abnormal_vitamin_homeostasis3.00928047
11MP0002822_catalepsy2.83013693
12MP0004043_abnormal_pH_regulation2.76232184
13MP0008875_abnormal_xenobiotic_pharmacok2.72631967
14MP0003252_abnormal_bile_duct2.53474729
15MP0005365_abnormal_bile_salt2.45139844
16MP0003866_abnormal_defecation2.40657850
17MP0009643_abnormal_urine_homeostasis2.37576823
18MP0000462_abnormal_digestive_system2.33631125
19MP0005332_abnormal_amino_acid2.29144218
20MP0003183_abnormal_peptide_metabolism2.23091363
21MP0003011_delayed_dark_adaptation2.12767185
22MP0000538_abnormal_urinary_bladder2.03079003
23MP0002876_abnormal_thyroid_physiology1.99229502
24MP0001765_abnormal_ion_homeostasis1.96408952
25MP0001873_stomach_inflammation1.96035722
26MP0005084_abnormal_gallbladder_morpholo1.86509854
27MP0001663_abnormal_digestive_system1.85087553
28MP0004147_increased_porphyrin_level1.80738670
29MP0005551_abnormal_eye_electrophysiolog1.76638731
30MP0000566_synostosis1.76411697
31MP0005381_digestive/alimentary_phenotyp1.73576696
32MP0003136_yellow_coat_color1.72820111
33MP0002138_abnormal_hepatobiliary_system1.69899879
34MP0003806_abnormal_nucleotide_metabolis1.65566310
35MP0003191_abnormal_cellular_cholesterol1.63679237
36MP0005636_abnormal_mineral_homeostasis1.63289864
37MP0003283_abnormal_digestive_organ1.61647454
38MP0010155_abnormal_intestine_physiology1.61001372
39MP0001986_abnormal_taste_sensitivity1.59093695
40MP0001664_abnormal_digestion1.58639100
41MP0003315_abnormal_perineum_morphology1.54494111
42MP0010329_abnormal_lipoprotein_level1.51862663
43MP0003300_gastrointestinal_ulcer1.51768204
44MP0000569_abnormal_digit_pigmentation1.48822059
45MP0002102_abnormal_ear_morphology1.47138485
46MP0002136_abnormal_kidney_physiology1.45461201
47MP0000477_abnormal_intestine_morphology1.45219501
48MP0010352_gastrointestinal_tract_polyps1.42644906
49MP0002796_impaired_skin_barrier1.40836670
50MP0009840_abnormal_foam_cell1.38361007
51MP0002638_abnormal_pupillary_reflex1.38024426
52MP0000490_abnormal_crypts_of1.35021203
53MP0002938_white_spotting1.34908768
54MP0000537_abnormal_urethra_morphology1.32288790
55MP0004142_abnormal_muscle_tone1.32078856
56MP0005167_abnormal_blood-brain_barrier1.28611005
57MP0001756_abnormal_urination1.27384520
58MP0003705_abnormal_hypodermis_morpholog1.25246543
59MP0001501_abnormal_sleep_pattern1.22719676
60MP0002653_abnormal_ependyma_morphology1.21916092
61MP0003868_abnormal_feces_composition1.21018236
62MP0004742_abnormal_vestibular_system1.20898639
63MP0004133_heterotaxia1.18056615
64MP0001968_abnormal_touch/_nociception1.13821538
65MP0003718_maternal_effect1.13343229
66MP0001529_abnormal_vocalization1.12198415
67MP0009745_abnormal_behavioral_response1.11469940
68MP0005451_abnormal_body_composition1.11103925
69MP0006072_abnormal_retinal_apoptosis1.09154309
70MP0005646_abnormal_pituitary_gland1.07576807
71MP0002089_abnormal_postnatal_growth/wei1.06315421
72MP0002272_abnormal_nervous_system0.99970015
73MP0005058_abnormal_lysosome_morphology0.98975792
74MP0002736_abnormal_nociception_after0.98231783
75MP0005253_abnormal_eye_physiology0.97369444
76MP0009697_abnormal_copulation0.97110801
77MP0003879_abnormal_hair_cell0.96827732
78MP0002928_abnormal_bile_duct0.94908751
79MP0005174_abnormal_tail_pigmentation0.94807446
80MP0002118_abnormal_lipid_homeostasis0.93864778
81MP0005501_abnormal_skin_physiology0.90594279
82MP0006054_spinal_hemorrhage0.90572064
83MP0005410_abnormal_fertilization0.90244813
84MP0005319_abnormal_enzyme/_coenzyme0.87944914
85MP0006292_abnormal_olfactory_placode0.87016890
86MP0001849_ear_inflammation0.85366958
87MP0000026_abnormal_inner_ear0.85072198
88MP0002557_abnormal_social/conspecific_i0.84751714
89MP0002064_seizures0.83202396
90MP0004924_abnormal_behavior0.82143643
91MP0005386_behavior/neurological_phenoty0.82143643
92MP0005448_abnormal_energy_balance0.82087166
93MP0005584_abnormal_enzyme/coenzyme_acti0.81450790
94MP0001486_abnormal_startle_reflex0.80757234
95MP0001324_abnormal_eye_pigmentation0.80701381
96MP0002837_dystrophic_cardiac_calcinosis0.77756444
97MP0005310_abnormal_salivary_gland0.77245668
98MP0010678_abnormal_skin_adnexa0.76805384
99MP0000427_abnormal_hair_cycle0.76144037
100MP0009764_decreased_sensitivity_to0.76044283
101MP0008877_abnormal_DNA_methylation0.75749580
102MP0000609_abnormal_liver_physiology0.75249063
103MP0009379_abnormal_foot_pigmentation0.74411048
104MP0008872_abnormal_physiological_respon0.73897327
105MP0005195_abnormal_posterior_eye0.73896297
106MP0005535_abnormal_body_temperature0.73004469
107MP0004885_abnormal_endolymph0.72312431
108MP0005666_abnormal_adipose_tissue0.71833674
109MP0010386_abnormal_urinary_bladder0.71735935
110MP0005645_abnormal_hypothalamus_physiol0.71594019
111MP0001905_abnormal_dopamine_level0.70834224
112MP0003880_abnormal_central_pattern0.70573845
113MP0003953_abnormal_hormone_level0.70156111
114MP0000631_abnormal_neuroendocrine_gland0.69921423
115MP0002735_abnormal_chemical_nociception0.68914691
116MP0002733_abnormal_thermal_nociception0.67763544
117MP0002572_abnormal_emotion/affect_behav0.65845593
118MP0002078_abnormal_glucose_homeostasis0.64693063
119MP0001970_abnormal_pain_threshold0.64449948
120MP0003646_muscle_fatigue0.64332817
121MP0003941_abnormal_skin_development0.64091189
122MP0002098_abnormal_vibrissa_morphology0.64053985
123MP0002282_abnormal_trachea_morphology0.64038023
124MP0002067_abnormal_sensory_capabilities0.63675396
125MP0000230_abnormal_systemic_arterial0.61982781
126MP0005166_decreased_susceptibility_to0.61761307
127MP0000470_abnormal_stomach_morphology0.61095444
128MP0009642_abnormal_blood_homeostasis0.60455432
129MP0000678_abnormal_parathyroid_gland0.58595883
130MP0003453_abnormal_keratinocyte_physiol0.58148087
131MP0004947_skin_inflammation0.57538482
132MP0004270_analgesia0.55372766
133MP0001216_abnormal_epidermal_layer0.54766368
134MP0001764_abnormal_homeostasis0.53915275
135MP0004858_abnormal_nervous_system0.51864199
136MP0003638_abnormal_response/metabolism_0.48468939
137MP0005266_abnormal_metabolism0.48194246
138MP0000467_abnormal_esophagus_morphology0.47326318
139MP0001485_abnormal_pinna_reflex0.46165234
140MP0008961_abnormal_basal_metabolism0.45301356
141MP0008873_increased_physiological_sensi0.44046823
142MP0003950_abnormal_plasma_membrane0.43719261
143MP0005367_renal/urinary_system_phenotyp0.42673252
144MP0000516_abnormal_urinary_system0.42673252
145MP0001958_emphysema0.42669042
146MP0006036_abnormal_mitochondrial_physio0.42664541
147MP0004782_abnormal_surfactant_physiolog0.41186679
148MP0004185_abnormal_adipocyte_glucose0.40932414
149MP0002254_reproductive_system_inflammat0.39379999
150MP0004484_altered_response_of0.38059048
151MP0002135_abnormal_kidney_morphology0.36915062
152MP0002896_abnormal_bone_mineralization0.36815561
153MP0005257_abnormal_intraocular_pressure0.35396793
154MP0001845_abnormal_inflammatory_respons0.35072546
155MP0008469_abnormal_protein_level0.34271363
156MP0002277_abnormal_respiratory_mucosa0.33449208

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.03535768
2Ileus (HP:0002595)5.75234182
3Malnutrition (HP:0004395)5.41384724
4Metabolic alkalosis (HP:0200114)5.34519782
5Hyperactive renin-angiotensin system (HP:0000841)4.93009670
6Hydroxyprolinuria (HP:0003080)4.91945282
7Abnormality of proline metabolism (HP:0010907)4.91945282
8Abnormality of chloride homeostasis (HP:0011422)4.43064046
9Hyperglycinuria (HP:0003108)4.37941624
10Proximal tubulopathy (HP:0000114)4.16721956
11Right ventricular cardiomyopathy (HP:0011663)4.10860135
12Gout (HP:0001997)3.83278301
13Glycosuria (HP:0003076)3.79063253
14Abnormality of urine glucose concentration (HP:0011016)3.79063253
15Abnormality of purine metabolism (HP:0004352)3.74166074
16Abnormality of magnesium homeostasis (HP:0004921)3.68669995
17Increased circulating renin level (HP:0000848)3.63369328
18Hypomagnesemia (HP:0002917)3.43503108
19Abnormality of renin-angiotensin system (HP:0000847)3.43072402
20Hyperuricemia (HP:0002149)3.36789158
21Increased purine levels (HP:0004368)3.36789158
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.36350603
23Widely patent fontanelles and sutures (HP:0004492)3.33663684
24Chronic diarrhea (HP:0002028)3.30748696
25Pancreatic cysts (HP:0001737)3.29668396
26Abnormal urine output (HP:0012590)3.24342281
27Abnormality of renal excretion (HP:0011036)3.24190317
28Alkalosis (HP:0001948)3.21057302
29True hermaphroditism (HP:0010459)3.18784357
30Prolonged partial thromboplastin time (HP:0003645)3.18578405
31Abnormality of the renal cortex (HP:0011035)3.15200244
32Abnormality of the vitamin B12 metabolism (HP:0004341)3.13839426
33Hypokalemic alkalosis (HP:0001949)3.13531923
34Abnormality of glycine metabolism (HP:0010895)3.13354283
35Abnormality of serine family amino acid metabolism (HP:0010894)3.13354283
36Hyperphosphaturia (HP:0003109)3.11601290
37Abnormal tarsal ossification (HP:0008369)3.11219440
38Generalized aminoaciduria (HP:0002909)3.08803743
39Nephrolithiasis (HP:0000787)3.08778576
40Dehydration (HP:0001944)3.07701364
41Molar tooth sign on MRI (HP:0002419)2.99749098
42Abnormality of midbrain morphology (HP:0002418)2.99749098
43Congenital stationary night blindness (HP:0007642)2.98348138
44Confusion (HP:0001289)2.98313035
45Abnormality of small intestinal villus morphology (HP:0011472)2.97503491
46Villous atrophy (HP:0011473)2.97503491
47Fat malabsorption (HP:0002630)2.96409690
48Renal cortical cysts (HP:0000803)2.94621975
49Cupped ribs (HP:0000887)2.94017738
50Abdominal distention (HP:0003270)2.93708685
51Polyuria (HP:0000103)2.92703578
52Pancreatic fibrosis (HP:0100732)2.91820012
53Congenital, generalized hypertrichosis (HP:0004540)2.90097655
54Type II lissencephaly (HP:0007260)2.89894795
55Abnormality of vitamin B metabolism (HP:0004340)2.89581800
56Hyperaldosteronism (HP:0000859)2.88242503
57Flat acetabular roof (HP:0003180)2.87141400
58Abnormal urine phosphate concentration (HP:0012599)2.83409264
59Abnormality of nucleobase metabolism (HP:0010932)2.83053537
60Delayed epiphyseal ossification (HP:0002663)2.82656854
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.82242657
62Hyperglycinemia (HP:0002154)2.79415927
63Hyperlipoproteinemia (HP:0010980)2.79311366
64Nephronophthisis (HP:0000090)2.76336625
65Conjugated hyperbilirubinemia (HP:0002908)2.74608723
66Hypercalciuria (HP:0002150)2.71826824
67Hypothermia (HP:0002045)2.67438703
68Intrahepatic cholestasis (HP:0001406)2.66575281
69Absent/shortened dynein arms (HP:0200106)2.65538845
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.65538845
71Acanthocytosis (HP:0001927)2.61056393
72Abnormality of carpal bone ossification (HP:0006257)2.57537789
73Chronic hepatic failure (HP:0100626)2.52468191
74Abnormality of the renal medulla (HP:0100957)2.49961685
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49885004
76Dicarboxylic aciduria (HP:0003215)2.49885004
77Vacuolated lymphocytes (HP:0001922)2.47531045
78Thin bony cortex (HP:0002753)2.46218039
79Hypokalemia (HP:0002900)2.45487668
80Pendular nystagmus (HP:0012043)2.44342413
81Sensorimotor neuropathy (HP:0007141)2.44175861
82Decreased central vision (HP:0007663)2.43224426
83Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42548944
84Hyperventilation (HP:0002883)2.41819675
85Abnormality of fatty-acid metabolism (HP:0004359)2.41776956
86Delayed CNS myelination (HP:0002188)2.40276406
87Attenuation of retinal blood vessels (HP:0007843)2.40074310
88Potter facies (HP:0002009)2.39746220
89Facial shape deformation (HP:0011334)2.39746220
90Bile duct proliferation (HP:0001408)2.39715080
91Abnormal biliary tract physiology (HP:0012439)2.39715080
92Goiter (HP:0000853)2.39557691
93Acute encephalopathy (HP:0006846)2.39499721
94Pigmentary retinal degeneration (HP:0001146)2.38088114
95Nausea (HP:0002018)2.37284354
96Ketoacidosis (HP:0001993)2.36855833
97Abnormality of vitamin metabolism (HP:0100508)2.35878201
98Autoimmune thrombocytopenia (HP:0001973)2.35143533
99Abnormality of aromatic amino acid family metabolism (HP:0004338)2.35008727
100Hypophosphatemia (HP:0002148)2.34228404
101Hypobetalipoproteinemia (HP:0003563)2.33185383
102Deep venous thrombosis (HP:0002625)2.31918818
103Hyperammonemia (HP:0001987)2.28009409
104Tetany (HP:0001281)2.27681057
105Gastrointestinal dysmotility (HP:0002579)2.27387063
106Pustule (HP:0200039)2.26126801
107Large for gestational age (HP:0001520)2.23774507
108Abnormal respiratory epithelium morphology (HP:0012253)2.23386010
109Abnormal respiratory motile cilium morphology (HP:0005938)2.23386010
110Fair hair (HP:0002286)2.22985383
111Epidermoid cyst (HP:0200040)2.22569904
112Abolished electroretinogram (ERG) (HP:0000550)2.22319556
113Complement deficiency (HP:0004431)2.21933758
114Palpitations (HP:0001962)2.20945854
115Polydipsia (HP:0001959)2.13617960
116Abnormal drinking behavior (HP:0030082)2.13617960
117Lethargy (HP:0001254)2.13512980
118Abnormality of serum amino acid levels (HP:0003112)2.11610148
119Metaphyseal cupping (HP:0003021)2.11482809
120Acute necrotizing encephalopathy (HP:0006965)2.11422682
121Abnormal foot bone ossification (HP:0010675)2.11397994
122Ketosis (HP:0001946)2.11357618
123Decreased circulating renin level (HP:0003351)2.09604684
124Hypolipoproteinemia (HP:0010981)2.09125797
125Congenital sensorineural hearing impairment (HP:0008527)2.08782531
126Cystic liver disease (HP:0006706)2.08673199
127Medial flaring of the eyebrow (HP:0010747)2.08426411
128Metabolic acidosis (HP:0001942)2.07705559
129Abnormal ciliary motility (HP:0012262)2.07564409
130Mitochondrial inheritance (HP:0001427)2.05979530
131Hyperparathyroidism (HP:0000843)2.05794634
132Wide cranial sutures (HP:0010537)2.04829686
1333-Methylglutaconic aciduria (HP:0003535)2.03699015
134Tubular atrophy (HP:0000092)2.03195200
135Xanthomatosis (HP:0000991)2.02449855
136Renal salt wasting (HP:0000127)2.02413925
137Late onset (HP:0003584)2.02386785
138Abnormality of the 1st metacarpal (HP:0010009)2.01661766
139Rickets (HP:0002748)1.99960050
140Abnormality of pyrimidine metabolism (HP:0004353)1.99849841
141Optic disc pallor (HP:0000543)1.98402524
142Focal segmental glomerulosclerosis (HP:0000097)1.98379769
143Abnormal rod and cone electroretinograms (HP:0008323)1.96566722
144Abnormality of the costochondral junction (HP:0000919)1.94125728
145Concave nail (HP:0001598)1.93780982
146Stomach cancer (HP:0012126)1.93587279
147Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92661507
148Abnormality of alanine metabolism (HP:0010916)1.92661507
149Hyperalaninemia (HP:0003348)1.92661507
150Abnormal hand bone ossification (HP:0010660)1.92248184
151Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91778881
152Vomiting (HP:0002013)1.91330313
153Cerebral edema (HP:0002181)1.91263310
154Abnormal respiratory motile cilium physiology (HP:0012261)1.88605749
155Chorioretinal atrophy (HP:0000533)1.88531414
156Male pseudohermaphroditism (HP:0000037)1.88511660
157Vascular calcification (HP:0004934)1.88381946
158Abnormal ossification of hand bones (HP:0005921)1.86534824
159Abnormality of potassium homeostasis (HP:0011042)1.86059933
160Abnormal number of erythroid precursors (HP:0012131)1.85430033
161Lipid accumulation in hepatocytes (HP:0006561)1.83779864
162Glomerulosclerosis (HP:0000096)1.82198167
163Cerebellar dysplasia (HP:0007033)1.81885967
164Tongue fasciculations (HP:0001308)1.81882071
165Progressive macrocephaly (HP:0004481)1.81137139
166Increased CSF lactate (HP:0002490)1.80774299
167Hepatic necrosis (HP:0002605)1.79291173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.11119052
2FRK5.17095591
3PIK3CA4.38583609
4MST44.22298247
5INSRR4.05355203
6ACVR1B4.02988417
7NME13.28033762
8ADRBK23.25730706
9WNK43.21766258
10LMTK23.13674418
11MAP2K23.12145284
12MAP3K23.02132892
13GRK62.79690402
14TLK12.64062739
15MAP4K22.49029775
16BMPR1B2.46405807
17ZAK2.41880540
18KSR22.34238372
19PRKG22.26615187
20MAPK152.26392858
21TAOK32.25858637
22RIPK12.17377495
23MYLK2.17299086
24OXSR12.13670016
25PINK12.05480792
26MET1.98064040
27TXK1.91434919
28CASK1.87240711
29PNCK1.83579489
30WNK31.81089339
31MAPK131.71149785
32EPHB21.60789372
33TESK11.59951525
34TNIK1.52425445
35AKT31.50555543
36MUSK1.47457425
37EPHA21.42895394
38PTK61.39163150
39ERN11.37443352
40ADRBK11.34357170
41TAOK11.33509087
42STK391.30223352
43TBK11.28210159
44TESK21.26004658
45MAP2K11.23806972
46VRK11.17674160
47CAMKK21.17627944
48DAPK21.16711896
49DYRK21.13792212
50TGFBR11.09903966
51PRKCI1.09116647
52PRKCG1.07180311
53PTK21.02846711
54TTK1.02145877
55MAP3K81.00988729
56PDK21.00196888
57EPHA40.97353962
58KIT0.97174171
59NTRK30.97143889
60NEK10.95830312
61MAP3K40.92327110
62STK100.92111806
63PIK3CG0.89859369
64STK38L0.89126111
65DDR20.88594800
66MAP3K70.88162932
67GRK70.87293770
68NLK0.86964377
69MARK10.84702083
70EPHB10.84131014
71BRSK20.84126769
72MAP2K60.83413266
73CAMK2D0.83067183
74MATK0.82245925
75MAP3K100.80210668
76NTRK20.79898281
77MAP3K30.77661374
78PRKCE0.77453030
79FGFR20.75672188
80PRKCQ0.74664211
81MAP3K10.73118620
82MAPK110.71463460
83VRK20.70428401
84PAK40.70373070
85PDK30.66791171
86PDK40.66791171
87PIM20.66733632
88PRKACA0.65998090
89NUAK10.65525082
90PDPK10.65245144
91FER0.64632301
92DMPK0.63413169
93PRKCZ0.63282324
94EPHA30.62089961
95IRAK10.62055595
96LIMK10.61311444
97MAP3K110.60123450
98IKBKB0.59347586
99WNK10.58735627
100PRKAA20.58284549
101MAP3K140.58243387
102MKNK20.57636476
103DYRK30.57286131
104RPS6KA50.55949865
105STK240.55546983
106TIE10.55055951
107LRRK20.54929217
108CHUK0.53512217
109PHKG20.50948373
110PHKG10.50948373
111CAMK2A0.49362755
112PRKG10.49183665
113RIPK40.47253280
114BCKDK0.47217635
115IKBKE0.46860696
116DYRK1B0.46725591
117ERBB20.46614028
118WEE10.45631662
119LATS10.44707068
120PASK0.43865533
121MAPKAPK50.42262431
122PLK40.42076571
123ARAF0.42001004
124MAP3K120.41622624
125CSNK1A10.40936463
126STK160.40739343
127PRKAA10.40259914
128IGF1R0.40164593
129SYK0.40029633
130PDK10.38409632
131PRKCA0.38019689
132DYRK1A0.37817009
133CAMK2G0.37576656
134TEC0.37374280
135ERBB30.37006747
136PAK30.36594564
137ITK0.35302113
138MAP2K70.34392177
139PTK2B0.33818247
140MAPKAPK30.31743837
141GRK50.31294844
142CSNK1G20.30736731
143SGK2230.30162525
144SGK4940.30162525
145PRKACB0.28751009
146IRAK40.28023005
147PAK10.26998941
148SRC0.26956162
149GSK3A0.26851167
150STK110.26742777
151LYN0.26588360
152PRKCD0.26272380
153CSK0.25909834
154PRKACG0.25908899
155CAMK2B0.25074746
156CDC42BPA0.24750094
157SGK30.23316938
158MELK0.22307629
159AURKB0.22121873
160OBSCN0.21489922
161ROCK10.20369865
162PIM10.19879889
163ABL20.16731811
164BMX0.15709295
165FGFR40.14773618
166BRAF0.13983563
167GRK10.13869250
168PBK0.12894997
169DAPK30.12844148
170AKT20.12004417

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.02613130
2Sulfur metabolism_Homo sapiens_hsa009203.91591103
3Fat digestion and absorption_Homo sapiens_hsa049753.87319114
4Mineral absorption_Homo sapiens_hsa049783.70382768
5Renin-angiotensin system_Homo sapiens_hsa046143.11873907
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94892882
7Vitamin digestion and absorption_Homo sapiens_hsa049772.82879134
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47239485
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.33231532
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32470918
11* Bile secretion_Homo sapiens_hsa049762.20637562
12Histidine metabolism_Homo sapiens_hsa003402.15274453
13Protein digestion and absorption_Homo sapiens_hsa049742.14632630
14Fructose and mannose metabolism_Homo sapiens_hsa000512.12503901
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03914190
16Butanoate metabolism_Homo sapiens_hsa006501.96322178
17Starch and sucrose metabolism_Homo sapiens_hsa005001.92588755
18Galactose metabolism_Homo sapiens_hsa000521.91362624
19Tryptophan metabolism_Homo sapiens_hsa003801.72548013
20PPAR signaling pathway_Homo sapiens_hsa033201.69295810
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68333554
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62116261
23Glutathione metabolism_Homo sapiens_hsa004801.59865483
24Fatty acid degradation_Homo sapiens_hsa000711.58907852
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56875316
26Pyruvate metabolism_Homo sapiens_hsa006201.55658940
27Complement and coagulation cascades_Homo sapiens_hsa046101.54265258
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.51937899
29Glycerolipid metabolism_Homo sapiens_hsa005611.51740557
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49972354
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44913962
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.41460146
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39168984
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32345934
35Arginine and proline metabolism_Homo sapiens_hsa003301.28699354
36Carbon metabolism_Homo sapiens_hsa012001.20085488
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19415042
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17733758
39beta-Alanine metabolism_Homo sapiens_hsa004101.15143323
40Propanoate metabolism_Homo sapiens_hsa006401.14043000
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13368169
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13137229
43Folate biosynthesis_Homo sapiens_hsa007901.11951029
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11656700
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08923622
46Peroxisome_Homo sapiens_hsa041460.98811727
47Caffeine metabolism_Homo sapiens_hsa002320.97046930
48Phototransduction_Homo sapiens_hsa047440.95790769
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95488594
50Arginine biosynthesis_Homo sapiens_hsa002200.95337661
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91054226
52Linoleic acid metabolism_Homo sapiens_hsa005910.89948317
53Pentose phosphate pathway_Homo sapiens_hsa000300.88637201
54Oxidative phosphorylation_Homo sapiens_hsa001900.87708412
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86528341
56Thyroid hormone synthesis_Homo sapiens_hsa049180.84045192
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.82501398
58Arachidonic acid metabolism_Homo sapiens_hsa005900.80378315
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79597875
60Nicotine addiction_Homo sapiens_hsa050330.76805508
61Tight junction_Homo sapiens_hsa045300.74693484
62Fatty acid metabolism_Homo sapiens_hsa012120.74092161
63Parkinsons disease_Homo sapiens_hsa050120.73597931
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73513635
65Sphingolipid metabolism_Homo sapiens_hsa006000.70617972
66Ribosome_Homo sapiens_hsa030100.64948361
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63745282
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.62211029
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62028624
70Chemical carcinogenesis_Homo sapiens_hsa052040.61946848
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.59784866
72Protein export_Homo sapiens_hsa030600.59528629
73ABC transporters_Homo sapiens_hsa020100.58209728
74Phenylalanine metabolism_Homo sapiens_hsa003600.56688543
75Cardiac muscle contraction_Homo sapiens_hsa042600.56072067
76Staphylococcus aureus infection_Homo sapiens_hsa051500.54119408
77Alzheimers disease_Homo sapiens_hsa050100.53945430
78Steroid biosynthesis_Homo sapiens_hsa001000.51372829
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50232603
80One carbon pool by folate_Homo sapiens_hsa006700.49325393
81Pancreatic secretion_Homo sapiens_hsa049720.48779716
82Metabolic pathways_Homo sapiens_hsa011000.48718629
83Serotonergic synapse_Homo sapiens_hsa047260.48279425
84Other glycan degradation_Homo sapiens_hsa005110.47648953
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.46882618
86Biosynthesis of amino acids_Homo sapiens_hsa012300.46058594
87Fatty acid biosynthesis_Homo sapiens_hsa000610.43254373
88Selenocompound metabolism_Homo sapiens_hsa004500.41338921
89Taste transduction_Homo sapiens_hsa047420.41317337
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41293049
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37651442
92Hepatitis C_Homo sapiens_hsa051600.36103586
93Ovarian steroidogenesis_Homo sapiens_hsa049130.35511785
94Retinol metabolism_Homo sapiens_hsa008300.33803979
95Gastric acid secretion_Homo sapiens_hsa049710.32963581
96Ether lipid metabolism_Homo sapiens_hsa005650.32585694
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32324381
98Thyroid cancer_Homo sapiens_hsa052160.32322817
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30849448
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.30256080
101Collecting duct acid secretion_Homo sapiens_hsa049660.29965336
102Asthma_Homo sapiens_hsa053100.29172923
103Nitrogen metabolism_Homo sapiens_hsa009100.28562199
104Insulin secretion_Homo sapiens_hsa049110.27889300
105Bladder cancer_Homo sapiens_hsa052190.27266092
106Cocaine addiction_Homo sapiens_hsa050300.26849292
107Huntingtons disease_Homo sapiens_hsa050160.24792245
108Salmonella infection_Homo sapiens_hsa051320.24258613
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.23906226
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23176454
111Choline metabolism in cancer_Homo sapiens_hsa052310.22599058
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22045291
113Salivary secretion_Homo sapiens_hsa049700.17313763
114Lysine degradation_Homo sapiens_hsa003100.17116901
115Olfactory transduction_Homo sapiens_hsa047400.16957527
116RNA polymerase_Homo sapiens_hsa030200.14775977
117Morphine addiction_Homo sapiens_hsa050320.14080341
118Sulfur relay system_Homo sapiens_hsa041220.13698894
119Vibrio cholerae infection_Homo sapiens_hsa051100.13653069
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13288927
121Fatty acid elongation_Homo sapiens_hsa000620.11891502
122Regulation of autophagy_Homo sapiens_hsa041400.11522876
123Type II diabetes mellitus_Homo sapiens_hsa049300.10782397
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.10758891
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09844110
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.08578576
127Tyrosine metabolism_Homo sapiens_hsa003500.07986394
128Adherens junction_Homo sapiens_hsa045200.05204434

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