SLC52A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunction, and axial and limb hypotonia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.47834339
2transcription from mitochondrial promoter (GO:0006390)7.70054359
3embryonic process involved in female pregnancy (GO:0060136)7.65021486
4DNA deamination (GO:0045006)7.26323671
5replication fork processing (GO:0031297)6.89590057
6positive regulation of protein homooligomerization (GO:0032464)6.34933385
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.85894601
8Golgi transport vesicle coating (GO:0048200)5.83742264
9COPI coating of Golgi vesicle (GO:0048205)5.83742264
10oxidative demethylation (GO:0070989)5.69409794
11regulation of integrin activation (GO:0033623)5.47762809
12regulation of protein homooligomerization (GO:0032462)5.41937134
13establishment of apical/basal cell polarity (GO:0035089)5.32705014
14mitochondrial DNA metabolic process (GO:0032042)5.30152584
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.90990648
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.90990648
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.84070091
18hemidesmosome assembly (GO:0031581)4.73115060
19poly(A)+ mRNA export from nucleus (GO:0016973)4.69331674
20DNA strand renaturation (GO:0000733)4.66833079
21viral mRNA export from host cell nucleus (GO:0046784)4.64550054
22establishment or maintenance of monopolar cell polarity (GO:0061339)4.62651131
23establishment of monopolar cell polarity (GO:0061162)4.62651131
24mitotic G1 DNA damage checkpoint (GO:0031571)4.62498337
25formation of translation preinitiation complex (GO:0001731)4.57295610
26telomere maintenance via semi-conservative replication (GO:0032201)4.52106473
27negative regulation of JAK-STAT cascade (GO:0046426)4.35655883
28protein maturation by protein folding (GO:0022417)4.29333648
29regulation of translational fidelity (GO:0006450)4.27784015
30base-excision repair (GO:0006284)4.27767297
31desmosome organization (GO:0002934)4.23777653
32activation of Rac GTPase activity (GO:0032863)4.21846587
33glutamine family amino acid biosynthetic process (GO:0009084)4.20150165
34negative regulation of cell cycle arrest (GO:0071157)4.17395348
35mitotic G1/S transition checkpoint (GO:0044819)4.15168379
36mitochondrial RNA metabolic process (GO:0000959)4.09275447
37mRNA cleavage (GO:0006379)4.08933062
38protein localization to endosome (GO:0036010)4.04104418
39G1 DNA damage checkpoint (GO:0044783)4.03711043
40cellular response to ATP (GO:0071318)4.01809686
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.01128492
42retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.99355912
43negative regulation of Ras GTPase activity (GO:0034261)3.99026867
44embryonic placenta development (GO:0001892)3.94765890
45base-excision repair, AP site formation (GO:0006285)3.90316028
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.86622416
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.84187857
48cellular response to zinc ion (GO:0071294)3.75988994
49positive regulation of protein oligomerization (GO:0032461)3.74766742
50trophectodermal cell differentiation (GO:0001829)3.74359546
51positive regulation of developmental pigmentation (GO:0048087)3.72662576
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.72598131
53positive regulation by host of viral transcription (GO:0043923)3.71478586
54GDP-mannose metabolic process (GO:0019673)3.67807885
55DNA strand elongation involved in DNA replication (GO:0006271)3.67197670
56regulation of mammary gland epithelial cell proliferation (GO:0033599)3.63327533
57cell-substrate junction assembly (GO:0007044)3.62394075
58epithelial cell-cell adhesion (GO:0090136)3.62291385
59DNA integration (GO:0015074)3.62177096
60negative regulation of fatty acid biosynthetic process (GO:0045717)3.61937075
61telomere maintenance via recombination (GO:0000722)3.61439687
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60940505
63negative regulation of protein oligomerization (GO:0032460)3.56919209
64spliceosomal tri-snRNP complex assembly (GO:0000244)3.56209902
65double-strand break repair via nonhomologous end joining (GO:0006303)3.50544547
66non-recombinational repair (GO:0000726)3.50544547
67negative regulation of cell size (GO:0045792)3.49922160
68mitotic nuclear envelope reassembly (GO:0007084)3.45925909
69nuclear envelope reassembly (GO:0031468)3.45925909
70DNA strand elongation (GO:0022616)3.44076526
71face development (GO:0060324)3.43659671
72regulation of protein oligomerization (GO:0032459)3.41885073
73skin morphogenesis (GO:0043589)3.39573863
74dosage compensation (GO:0007549)3.39325302
75basement membrane organization (GO:0071711)3.39304858
76histone H4-K12 acetylation (GO:0043983)3.38593349
77regulation of early endosome to late endosome transport (GO:2000641)3.37081569
78termination of RNA polymerase II transcription (GO:0006369)3.35732141
79pyrimidine nucleotide catabolic process (GO:0006244)3.33504368
80pentose-phosphate shunt (GO:0006098)3.32033335
81focal adhesion assembly (GO:0048041)3.31761481
82cell-substrate adherens junction assembly (GO:0007045)3.31761481
83maturation of 5.8S rRNA (GO:0000460)3.31593412
84regulation of sister chromatid cohesion (GO:0007063)3.30625308
85positive regulation of Cdc42 GTPase activity (GO:0043089)3.30589104
86adherens junction assembly (GO:0034333)3.30469202
87glucose catabolic process (GO:0006007)3.30059934
88planar cell polarity pathway involved in neural tube closure (GO:0090179)3.28759734
89meiotic chromosome segregation (GO:0045132)3.27799023
90apoptotic process involved in morphogenesis (GO:0060561)3.27087792
91maternal placenta development (GO:0001893)3.24875021
92DNA topological change (GO:0006265)3.21971923
93barbed-end actin filament capping (GO:0051016)3.21790081
94nodal signaling pathway (GO:0038092)3.20975595
95regulation of double-strand break repair via homologous recombination (GO:0010569)3.20389109
96semaphorin-plexin signaling pathway (GO:0071526)3.11521417
97negative regulation of mRNA processing (GO:0050686)3.10520462
98positive regulation of mitotic sister chromatid separation (GO:1901970)3.07826589
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.07826589
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.07826589
101negative regulation of tumor necrosis factor production (GO:0032720)3.06470966
102regulation of RNA export from nucleus (GO:0046831)3.06054413
103DNA double-strand break processing (GO:0000729)3.05203531
104activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.01264602
105kinetochore assembly (GO:0051382)3.00832303
106positive regulation of DNA repair (GO:0045739)3.00276898
107mitochondrial DNA replication (GO:0006264)2.99379421
108endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.99310915
109intracellular estrogen receptor signaling pathway (GO:0030520)2.99140746
110chaperone mediated protein folding requiring cofactor (GO:0051085)2.98857890
111positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.98698485
112mitotic recombination (GO:0006312)2.98501596
113branching involved in mammary gland duct morphogenesis (GO:0060444)2.98102455
114telomere maintenance via telomere lengthening (GO:0010833)2.96463878
115embryonic camera-type eye development (GO:0031076)2.96208020
116negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.95874516
117labyrinthine layer development (GO:0060711)2.95596613
118anatomical structure regression (GO:0060033)2.95381670
119resolution of meiotic recombination intermediates (GO:0000712)2.92867721
120DNA ligation (GO:0006266)2.92265439
121regulation of double-strand break repair (GO:2000779)2.91690309
122positive regulation of nuclease activity (GO:0032075)2.91523180
123negative regulation of viral release from host cell (GO:1902187)2.91155979
124regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.89731206
125regulation of apoptotic process involved in morphogenesis (GO:1902337)2.89540302
126glial cell migration (GO:0008347)2.88886469
127glucose 6-phosphate metabolic process (GO:0051156)2.88586049
128negative regulation of RNA splicing (GO:0033119)2.87298502
129convergent extension (GO:0060026)2.87218981
130NADPH regeneration (GO:0006740)2.85001776
131amyloid precursor protein catabolic process (GO:0042987)2.84372380
132single strand break repair (GO:0000012)2.83259689
133protein retention in ER lumen (GO:0006621)2.82999345
134regulation of cell size (GO:0008361)2.82516972
135endoplasmic reticulum unfolded protein response (GO:0030968)2.82311516
136mRNA polyadenylation (GO:0006378)2.81085872
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.80257644
138sphingomyelin metabolic process (GO:0006684)2.78897776
139UV protection (GO:0009650)2.77630932
140peptidyl-arginine omega-N-methylation (GO:0035247)2.77022170
141mitotic chromosome condensation (GO:0007076)2.75500818
142pinocytosis (GO:0006907)2.74485299
143regulation of translational termination (GO:0006449)2.71462828
144negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.69884293
145stress fiber assembly (GO:0043149)2.68608269
146regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66441445
147ER-nucleus signaling pathway (GO:0006984)2.63203883
148regulation of nuclease activity (GO:0032069)2.60780362
149regulation of cholesterol biosynthetic process (GO:0045540)2.59483056
150cellular response to unfolded protein (GO:0034620)2.58690449
151endothelial cell chemotaxis (GO:0035767)2.57578516
152atrioventricular valve morphogenesis (GO:0003181)2.56897023
153endothelial cell morphogenesis (GO:0001886)2.56174046
154cytoskeletal anchoring at plasma membrane (GO:0007016)2.55451581
155cell-cell junction maintenance (GO:0045217)2.54854412
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51113869
157nucleobase-containing small molecule interconversion (GO:0015949)2.47967855
158regulation of glucose import in response to insulin stimulus (GO:2001273)2.47047078
159embryo implantation (GO:0007566)2.45274503
160positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.44084138
161cell adhesion mediated by integrin (GO:0033627)2.43622347
162cellular response to topologically incorrect protein (GO:0035967)2.43368847
163apoptotic process involved in development (GO:1902742)2.42606494
164peptidyl-proline hydroxylation (GO:0019511)2.42445668
165regulation of extracellular matrix disassembly (GO:0010715)2.38205770
166DNA unwinding involved in DNA replication (GO:0006268)2.37862304
167decidualization (GO:0046697)2.37046050
168protein complex localization (GO:0031503)2.36530893
169vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.35976501
170membrane protein ectodomain proteolysis (GO:0006509)2.33889567
171virion assembly (GO:0019068)2.33713298
172cellular protein complex localization (GO:0034629)2.33626032
173ncRNA 3-end processing (GO:0043628)2.32662677
174regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.32345644
175positive regulation of keratinocyte differentiation (GO:0045618)2.31535082
176regulation of water loss via skin (GO:0033561)2.31239524
177hyaluronan catabolic process (GO:0030214)2.31100749
178positive regulation of blood vessel endothelial cell migration (GO:0043536)2.31045598
179trophoblast giant cell differentiation (GO:0060707)2.30909692
180NIK/NF-kappaB signaling (GO:0038061)2.30473180
181serine transport (GO:0032329)2.29452291
182positive regulation of receptor recycling (GO:0001921)2.29217867
183positive regulation of pseudopodium assembly (GO:0031274)2.29169552
184proline biosynthetic process (GO:0006561)10.7264492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.29687468
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.36559666
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.96340554
4E2F7_22180533_ChIP-Seq_HELA_Human2.88731480
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.80506362
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77233053
7VDR_21846776_ChIP-Seq_THP-1_Human2.74816610
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65510928
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.55827573
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52959108
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.42687839
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.42687839
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.42687839
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28319097
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26645831
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.19678836
17KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.14163639
18LXR_22292898_ChIP-Seq_THP-1_Human2.01969689
19MYC_22102868_ChIP-Seq_BL_Human1.99392549
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97511078
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86604941
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86580314
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84822063
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84581778
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84309694
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84143020
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.81792683
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.77897327
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.76580319
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76415894
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75928093
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74654707
33PU.1_20513432_ChIP-Seq_Bcells_Mouse1.73785701
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71278392
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65547434
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64444577
37POU5F1_16518401_ChIP-PET_MESCs_Mouse1.61898115
38ATF3_27146783_Chip-Seq_COLON_Human1.57237847
39TCF3_18692474_ChIP-Seq_MESCs_Mouse1.56636229
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.56201676
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55848897
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55073701
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.54757160
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.53597836
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52872589
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51841825
47RACK7_27058665_Chip-Seq_MCF-7_Human1.51181676
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50866766
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49441989
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49383027
51NANOG_21062744_ChIP-ChIP_HESCs_Human1.48356492
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48048020
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.47583987
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.47095930
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46107226
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43815110
57GABP_19822575_ChIP-Seq_HepG2_Human1.42149397
58TCF7_22412390_ChIP-Seq_EML_Mouse1.39697736
59P68_20966046_ChIP-Seq_HELA_Human1.38603413
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38244452
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38061284
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37935963
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37528729
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36109249
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36084332
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.35375471
67DCP1A_22483619_ChIP-Seq_HELA_Human1.34137779
68ZNF263_19887448_ChIP-Seq_K562_Human1.33562922
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32997742
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31820972
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31507641
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30561022
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.28973472
74CLOCK_20551151_ChIP-Seq_293T_Human1.28728531
75KDM2B_26808549_Chip-Seq_DND41_Human1.27642440
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27125566
77POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26795327
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26519385
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26439930
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25944910
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.25570918
82KDM2B_26808549_Chip-Seq_K562_Human1.25090691
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24623534
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24396062
85TP53_22127205_ChIP-Seq_IMR90_Human1.24230586
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23876429
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23565118
88XRN2_22483619_ChIP-Seq_HELA_Human1.23377031
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22636815
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22092067
91SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21465721
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.20589015
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20428293
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19967811
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19937439
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19282929
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19273185
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18898378
99CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18865600
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18141893
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18111645
102KDM5A_27292631_Chip-Seq_BREAST_Human1.17878726
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17522370
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17424206
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17174290
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16760018
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16639982
108ETS1_21867929_ChIP-Seq_TH2_Mouse1.16616892
109* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16254746
110SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14507666
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13180736
112OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12552707
113BCOR_27268052_Chip-Seq_Bcells_Human1.12402635
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12135460
115SMC4_20622854_ChIP-Seq_HELA_Human1.11831699
116CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11582733
117ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10838115
118PHF8_20622854_ChIP-Seq_HELA_Human1.09982428
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.09249605
120VDR_24763502_ChIP-Seq_THP-1_Human1.09240230
121RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09059938
122EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08659914
123NCOR1_26117541_ChIP-Seq_K562_Human1.08632950
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08232709
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.08020557
126SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07583143
127CREB1_26743006_Chip-Seq_LNCaP_Human1.06775781
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06632704
129UBF1/2_26484160_Chip-Seq_HMECs_Human1.06368153
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06310081
131TTF2_22483619_ChIP-Seq_HELA_Human1.05747864
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05030714
133YY1_22570637_ChIP-Seq_MALME-3M_Human1.04677009
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04104687
135STAT1_20625510_ChIP-Seq_HELA_Human1.03878450
136ESR1_21235772_ChIP-Seq_MCF-7_Human1.02964694
137NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02957059
138BCL6_27268052_Chip-Seq_Bcells_Human1.02671083
139CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02523031
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02498636
141SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02004839
142ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01974033
143CTCF_26484167_Chip-Seq_Bcells_Mouse0.99958032
144MAF_26560356_Chip-Seq_TH1_Human0.99814778
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.99753823
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.98389580
147ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97885800
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97587035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.60808068
2MP0003705_abnormal_hypodermis_morpholog4.32558225
3MP0009278_abnormal_bone_marrow4.30837538
4MP0005171_absent_coat_pigmentation4.01826212
5MP0010234_abnormal_vibrissa_follicle3.70058546
6MP0010030_abnormal_orbit_morphology3.47744303
7MP0008438_abnormal_cutaneous_collagen3.31410084
8MP0002877_abnormal_melanocyte_morpholog3.00407345
9MP0003566_abnormal_cell_adhesion2.79852605
10MP0005451_abnormal_body_composition2.75050905
11MP0005174_abnormal_tail_pigmentation2.62808081
12MP0004233_abnormal_muscle_weight2.60120150
13MP0005257_abnormal_intraocular_pressure2.57245795
14MP0008995_early_reproductive_senescence2.53796167
15MP0005397_hematopoietic_system_phenotyp2.49392304
16MP0001545_abnormal_hematopoietic_system2.49392304
17MP0001849_ear_inflammation2.47198983
18MP0003191_abnormal_cellular_cholesterol2.44317034
19MP0004272_abnormal_basement_membrane2.35181815
20MP0002009_preneoplasia2.34625943
21MP0008260_abnormal_autophagy2.30508185
22MP0010094_abnormal_chromosome_stability2.26110050
23MP0004957_abnormal_blastocyst_morpholog2.21409738
24MP0000490_abnormal_crypts_of2.11817480
25MP0004858_abnormal_nervous_system2.10725840
26MP0005058_abnormal_lysosome_morphology2.07043213
27MP0003890_abnormal_embryonic-extraembry1.98366752
28MP0003693_abnormal_embryo_hatching1.97427754
29MP0003786_premature_aging1.96701742
30MP0003283_abnormal_digestive_organ1.95452263
31MP0005075_abnormal_melanosome_morpholog1.94052506
32MP0000015_abnormal_ear_pigmentation1.93307311
33MP0000537_abnormal_urethra_morphology1.91720444
34MP0003111_abnormal_nucleus_morphology1.80171441
35MP0003172_abnormal_lysosome_physiology1.79953376
36MP0004185_abnormal_adipocyte_glucose1.75111000
37MP0005076_abnormal_cell_differentiation1.73687388
38MP0002653_abnormal_ependyma_morphology1.73582095
39MP0003453_abnormal_keratinocyte_physiol1.71124275
40MP0008932_abnormal_embryonic_tissue1.70185533
41MP0000858_altered_metastatic_potential1.67346206
42MP0000462_abnormal_digestive_system1.63633823
43MP0010352_gastrointestinal_tract_polyps1.58749656
44MP0004133_heterotaxia1.57880145
45MP0003119_abnormal_digestive_system1.56559892
46MP0002086_abnormal_extraembryonic_tissu1.56386087
47MP0000371_diluted_coat_color1.54128237
48MP0001697_abnormal_embryo_size1.52965271
49MP0004264_abnormal_extraembryonic_tissu1.52407141
50MP0003091_abnormal_cell_migration1.51787459
51MP0000467_abnormal_esophagus_morphology1.51179652
52MP0001216_abnormal_epidermal_layer1.50394993
53MP0000678_abnormal_parathyroid_gland1.48453442
54MP0003077_abnormal_cell_cycle1.47962542
55MP0002249_abnormal_larynx_morphology1.46161810
56MP0001348_abnormal_lacrimal_gland1.44481256
57MP0002084_abnormal_developmental_patter1.43762500
58MP0006072_abnormal_retinal_apoptosis1.42036941
59MP0001293_anophthalmia1.40651314
60MP0002254_reproductive_system_inflammat1.38085541
61MP0002085_abnormal_embryonic_tissue1.37189254
62MP0009333_abnormal_splenocyte_physiolog1.35869013
63MP0003718_maternal_effect1.34730969
64MP0000685_abnormal_immune_system1.33647493
65MP0004947_skin_inflammation1.33401484
66MP0002282_abnormal_trachea_morphology1.32616349
67MP0000470_abnormal_stomach_morphology1.31665707
68MP0005623_abnormal_meninges_morphology1.31145124
69MP0003656_abnormal_erythrocyte_physiolo1.30503344
70MP0000003_abnormal_adipose_tissue1.28775872
71MP0008058_abnormal_DNA_repair1.28458526
72MP0001672_abnormal_embryogenesis/_devel1.25325769
73MP0005380_embryogenesis_phenotype1.25325769
74MP0002089_abnormal_postnatal_growth/wei1.24019511
75MP0004019_abnormal_vitamin_homeostasis1.22152955
76MP0008877_abnormal_DNA_methylation1.18615033
77MP0003279_aneurysm1.18127709
78MP0002098_abnormal_vibrissa_morphology1.17625216
79MP0010771_integument_phenotype1.17520698
80MP0001730_embryonic_growth_arrest1.16821734
81MP0009840_abnormal_foam_cell1.16202211
82MP0002405_respiratory_system_inflammati1.15518796
83MP0002019_abnormal_tumor_incidence1.15429111
84MP0005085_abnormal_gallbladder_physiolo1.14108907
85MP0002269_muscular_atrophy1.13050130
86MP0000751_myopathy1.12409937
87MP0002396_abnormal_hematopoietic_system1.11402198
88MP0000350_abnormal_cell_proliferation1.11295361
89MP0000579_abnormal_nail_morphology1.09321742
90MP0005360_urolithiasis1.07867618
91MP0004197_abnormal_fetal_growth/weight/1.07469125
92MP0003763_abnormal_thymus_physiology1.06122703
93MP0000733_abnormal_muscle_development1.05337067
94MP0001243_abnormal_dermal_layer1.04981988
95MP0002080_prenatal_lethality1.02792878
96MP0003567_abnormal_fetal_cardiomyocyte1.02092321
97MP0009931_abnormal_skin_appearance1.01822752
98MP0002796_impaired_skin_barrier1.01483214
99MP0000639_abnormal_adrenal_gland1.01394967
100MP0002111_abnormal_tail_morphology0.99938926
101MP0005621_abnormal_cell_physiology0.98989976
102MP0009053_abnormal_anal_canal0.98291492
103MP0005375_adipose_tissue_phenotype0.98265835
104MP0000689_abnormal_spleen_morphology0.97824631
105MP0000477_abnormal_intestine_morphology0.97425180
106MP0000566_synostosis0.96679974
107MP0003866_abnormal_defecation0.96554838
108MP0003984_embryonic_growth_retardation0.95601622
109MP0005508_abnormal_skeleton_morphology0.94982137
110MP0002075_abnormal_coat/hair_pigmentati0.94683064
111MP0006082_CNS_inflammation0.92691611
112MP0004510_myositis0.92327108
113MP0000377_abnormal_hair_follicle0.91285180
114MP0002088_abnormal_embryonic_growth/wei0.91132437
115MP0005365_abnormal_bile_salt0.91053133
116MP0001881_abnormal_mammary_gland0.89921073
117MP0004782_abnormal_surfactant_physiolog0.88762750
118MP0005666_abnormal_adipose_tissue0.88519742
119MP0003123_paternal_imprinting0.88423375
120MP0001958_emphysema0.87779206
121MP0000313_abnormal_cell_death0.87747302
122MP0001873_stomach_inflammation0.86570068
123MP0000767_abnormal_smooth_muscle0.84859171
124MP0003941_abnormal_skin_development0.84538639
125MP0009384_cardiac_valve_regurgitation0.83854219
126MP0003436_decreased_susceptibility_to0.83850478
127MP0003329_amyloid_beta_deposits0.82925367
128MP0002932_abnormal_joint_morphology0.82491866
129MP0005501_abnormal_skin_physiology0.82273086
130MP0009115_abnormal_fat_cell0.81691730
131MP0009672_abnormal_birth_weight0.81264425
132MP0003300_gastrointestinal_ulcer0.80037892
133MP0005409_darkened_coat_color0.79895523
134MP0002896_abnormal_bone_mineralization0.78884706
135MP0002998_abnormal_bone_remodeling0.78810835
136MP0010155_abnormal_intestine_physiology0.78702589
137MP0008007_abnormal_cellular_replicative0.77781644
138MP0003806_abnormal_nucleotide_metabolis0.77365832
139MP0003828_pulmonary_edema0.77197351
140MP0005266_abnormal_metabolism0.77180714
141MP0000750_abnormal_muscle_regeneration0.76810590
142MP0000358_abnormal_cell_content/0.76633201
143MP0002166_altered_tumor_susceptibility0.76532522
144MP0000627_abnormal_mammary_gland0.76333985
145MP0005384_cellular_phenotype0.75615805
146MP0001661_extended_life_span0.74939644
147MP0002722_abnormal_immune_system0.73167950
148MP0001324_abnormal_eye_pigmentation0.73094990
149MP0001186_pigmentation_phenotype0.72568194
150MP0002114_abnormal_axial_skeleton0.72526055
151MP0003448_altered_tumor_morphology0.72351702
152MP0000762_abnormal_tongue_morphology0.71040908
153MP0005390_skeleton_phenotype0.70465753
154MP0002970_abnormal_white_adipose0.70233280
155MP0001340_abnormal_eyelid_morphology0.69960857
156MP0002060_abnormal_skin_morphology0.69743030
157MP0001853_heart_inflammation0.68561287
158MP0000343_altered_response_to0.68464105
159MP0001542_abnormal_bone_strength0.67981396
160MP0005165_increased_susceptibility_to0.67721510
161MP0002398_abnormal_bone_marrow0.67183680
162MP0001145_abnormal_male_reproductive0.66697556
163MP0005023_abnormal_wound_healing0.66273653
164MP0003075_altered_response_to0.65771822
165MP0000703_abnormal_thymus_morphology0.65633911
166MP0003935_abnormal_craniofacial_develop0.64742432
167MP0003045_fibrosis0.64617027
168MP0000534_abnormal_ureter_morphology0.63629272
169MP0003755_abnormal_palate_morphology0.62817417
170MP0005275_abnormal_skin_tensile0.62767367

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)6.08967239
2Concave nail (HP:0001598)5.48804898
3Rib fusion (HP:0000902)5.40292934
4Poikiloderma (HP:0001029)5.15869993
5Premature rupture of membranes (HP:0001788)4.90385562
6Annular pancreas (HP:0001734)4.79649802
7Facial hemangioma (HP:0000329)4.75782965
8Increased IgM level (HP:0003496)4.62720859
9Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.44221178
10Rectovaginal fistula (HP:0000143)4.32293380
11Rectal fistula (HP:0100590)4.32293380
12Ulnar bowing (HP:0003031)4.19731558
13Alopecia of scalp (HP:0002293)4.11395823
14Vaginal fistula (HP:0004320)3.96368994
15Intestinal fistula (HP:0100819)3.94305712
16Turricephaly (HP:0000262)3.93741455
17Short humerus (HP:0005792)3.87350500
18Aplasia/hypoplasia of the humerus (HP:0006507)3.80877352
19Abnormal hemoglobin (HP:0011902)3.70856075
20Albinism (HP:0001022)3.67990876
21Vertebral compression fractures (HP:0002953)3.55693775
22Coronal craniosynostosis (HP:0004440)3.51346189
23Mucopolysacchariduria (HP:0008155)3.46834303
24Urinary glycosaminoglycan excretion (HP:0003541)3.46834303
25Male infertility (HP:0003251)3.46042695
26Hyperacusis (HP:0010780)3.44118568
27Protrusio acetabuli (HP:0003179)3.39571446
28Orthostatic hypotension (HP:0001278)3.37928202
29Hypochromic microcytic anemia (HP:0004840)3.34018803
30Squamous cell carcinoma (HP:0002860)3.30288608
31Abnormality of male internal genitalia (HP:0000022)3.24582259
32Basal cell carcinoma (HP:0002671)3.23902205
33Achilles tendon contracture (HP:0001771)3.23748342
34Absent radius (HP:0003974)3.22209029
35Premature skin wrinkling (HP:0100678)3.21265548
36Distal upper limb amyotrophy (HP:0007149)3.19528526
37Upper limb amyotrophy (HP:0009129)3.19528526
38Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.19497118
39Vertebral hypoplasia (HP:0008417)3.19497118
40Dysostosis multiplex (HP:0000943)3.18102426
41Anteriorly placed anus (HP:0001545)3.17098206
42Fragile skin (HP:0001030)3.11240568
43Abnormality of mucopolysaccharide metabolism (HP:0011020)3.08147935
44Abnormality of polysaccharide metabolism (HP:0011012)3.08147935
45Abnormality of glycosaminoglycan metabolism (HP:0004371)3.08147935
46Diaphragmatic weakness (HP:0009113)3.08072351
47Distal lower limb amyotrophy (HP:0008944)3.07380890
48Atrophic scars (HP:0001075)3.06707527
49Absent forearm bone (HP:0003953)3.02195312
50Aplasia involving forearm bones (HP:0009822)3.02195312
51Absent thumb (HP:0009777)3.01561831
52Dysautonomia (HP:0002459)2.96808794
53Congenital hip dislocation (HP:0001374)2.93369464
54Short nail (HP:0001799)2.92663355
55Large for gestational age (HP:0001520)2.92184695
56Distal lower limb muscle weakness (HP:0009053)2.92139467
57Short chin (HP:0000331)2.91744370
58J-shaped sella turcica (HP:0002680)2.88646285
59Cervical subluxation (HP:0003308)2.88256779
60Joint stiffness (HP:0001387)2.83967231
61Abnormality of the Achilles tendon (HP:0005109)2.81811764
62Increased connective tissue (HP:0009025)2.79939245
63Premature graying of hair (HP:0002216)2.77579738
64Alacrima (HP:0000522)2.76763734
65Patellar aplasia (HP:0006443)2.76020564
66Hypochromic anemia (HP:0001931)2.75238476
67IgA deficiency (HP:0002720)2.72613623
68Aplasia of the musculature (HP:0100854)2.69722801
69Trismus (HP:0000211)2.69347883
70Abnormality of the aortic arch (HP:0012303)2.68434808
71Intestinal atresia (HP:0011100)2.66950270
72Abnormality of the distal phalanges of the toes (HP:0010182)2.65361065
73Broad face (HP:0000283)2.62692745
74Polycythemia (HP:0001901)2.60427298
75Elbow flexion contracture (HP:0002987)2.58693096
76Aplasia/Hypoplasia of the patella (HP:0006498)2.57033910
77Selective tooth agenesis (HP:0001592)2.55332966
78Choanal stenosis (HP:0000452)2.53793225
79Growth hormone excess (HP:0000845)2.51489784
80Spinal rigidity (HP:0003306)2.50960496
81Pancreatic islet-cell hyperplasia (HP:0004510)2.46337317
82Broad alveolar ridges (HP:0000187)2.43949216
83Cheilitis (HP:0100825)2.40956126
84Capillary hemangiomas (HP:0005306)2.40388844
85Bowing of the arm (HP:0006488)2.39748426
86Bowed forearm bones (HP:0003956)2.39748426
87Bifid uvula (HP:0000193)2.36877490
88Axonal loss (HP:0003447)2.36652591
89Ankle contracture (HP:0006466)2.36384556
90Difficulty climbing stairs (HP:0003551)2.35573558
91Flat acetabular roof (HP:0003180)2.35200385
92Hypotrichosis (HP:0001006)2.35126237
93Redundant skin (HP:0001582)2.33263141
94Hand muscle atrophy (HP:0009130)2.32351758
95Long palpebral fissure (HP:0000637)2.32222638
96Muscle fiber atrophy (HP:0100295)2.31861956
97Cerebral aneurysm (HP:0004944)2.31658880
98Abnormality of placental membranes (HP:0011409)2.30789542
99Amniotic constriction ring (HP:0009775)2.30789542
100Mildly elevated creatine phosphokinase (HP:0008180)2.30604732
101Exertional dyspnea (HP:0002875)2.30003821
102Popliteal pterygium (HP:0009756)2.26225796
103Hypoplasia of the radius (HP:0002984)2.24394065
104Stridor (HP:0010307)2.21367782
105Thin bony cortex (HP:0002753)2.20813144
106Blue sclerae (HP:0000592)2.20150162
107Disproportionate tall stature (HP:0001519)2.19921977
108Hamartoma (HP:0010566)2.19127003
109Abnormality of glycolipid metabolism (HP:0010969)2.18908571
110Abnormality of liposaccharide metabolism (HP:0010968)2.18908571
111Abnormality of glycosphingolipid metabolism (HP:0004343)2.18908571
112Breast hypoplasia (HP:0003187)2.17994989
113Shallow orbits (HP:0000586)2.16114855
114Hypotelorism (HP:0000601)2.13963991
115Back pain (HP:0003418)2.13001983
116Volvulus (HP:0002580)2.11819396
117Abnormality of the umbilical cord (HP:0010881)2.11637531
118Natal tooth (HP:0000695)2.11204706
119Amelogenesis imperfecta (HP:0000705)2.11093551
120Acute lymphatic leukemia (HP:0006721)2.09865944
121Rough bone trabeculation (HP:0100670)2.08829899
122Insomnia (HP:0100785)2.08117415
123Type 2 muscle fiber atrophy (HP:0003554)2.06322004
124Vertebral fusion (HP:0002948)2.06174917
125Flattened epiphyses (HP:0003071)2.05763484
126Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05697004
127Bladder diverticulum (HP:0000015)2.04780912
128Gastrointestinal dysmotility (HP:0002579)2.04707662
129Abnormality of dentin (HP:0010299)2.04001840
130Entropion (HP:0000621)2.02734974
131Fragile nails (HP:0001808)2.02699235
132Osteolytic defects of the hand bones (HP:0009699)2.01997505
133Osteolytic defects of the phalanges of the hand (HP:0009771)2.01997505
134Nail dystrophy (HP:0008404)2.01932970
135Colitis (HP:0002583)2.01489995
136Increased cerebral lipofuscin (HP:0011813)1.99010491
137Abnormality of T cell physiology (HP:0011840)1.96555865
138Short 5th finger (HP:0009237)1.96369701
139Biconcave vertebral bodies (HP:0004586)1.94996642
140Mitral regurgitation (HP:0001653)1.93927622
141Pili torti (HP:0003777)1.93417808
142Decreased lacrimation (HP:0000633)1.93314402
143Spinal muscular atrophy (HP:0007269)1.93187596
144Increased number of teeth (HP:0011069)1.91745808
145Lower limb amyotrophy (HP:0007210)1.91503190
146Bilateral sensorineural hearing impairment (HP:0008619)1.89646085
147Abnormality of the thoracic spine (HP:0100711)1.89102923
148Abnormality of the labia minora (HP:0012880)1.88114894
149* Generalized amyotrophy (HP:0003700)1.88103934
150Lower limb hyperreflexia (HP:0002395)1.87955577
151Wormian bones (HP:0002645)1.87556345
152Milia (HP:0001056)1.87139466
153Hyperparathyroidism (HP:0000843)1.86541919
154Metaphyseal cupping (HP:0003021)1.86360301
155Nuclear cataract (HP:0100018)1.85816068
156Increased neuronal autofluorescent lipopigment (HP:0002074)1.84435280
157Hypoplasia of the ulna (HP:0003022)1.82562897
158Genu recurvatum (HP:0002816)1.82293149
159Advanced eruption of teeth (HP:0006288)1.82007418
160Hypercortisolism (HP:0001578)1.81911722
161Asymmetric septal hypertrophy (HP:0001670)1.81751434
162Loss of speech (HP:0002371)1.79827558
163Deviation of the thumb (HP:0009603)1.77693290
164Spinal cord compression (HP:0002176)1.77516699
165Gastrointestinal atresia (HP:0002589)1.76807922
166Congenital glaucoma (HP:0001087)1.76657435
167Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.75405537
168Patellar dislocation (HP:0002999)1.75354739
169Easy fatigability (HP:0003388)1.74779178
170Abdominal distention (HP:0003270)1.74622437
171Bone pain (HP:0002653)1.70680000
172Abnormality of carpal bone ossification (HP:0006257)1.70050380
173Acanthosis nigricans (HP:0000956)1.69951228
174Abnormal trabecular bone morphology (HP:0100671)1.69892012
175Progressive muscle weakness (HP:0003323)1.69464032
176Centrally nucleated skeletal muscle fibers (HP:0003687)1.69432629
177Abnormal ossification of hand bones (HP:0005921)1.69374589
178Nonimmune hydrops fetalis (HP:0001790)1.69236627
179Pterygium (HP:0001059)1.67151144
180Reduced subcutaneous adipose tissue (HP:0003758)1.67130539
181Abnormality of oral frenula (HP:0000190)1.66813726
182Hemorrhage of the eye (HP:0011885)1.66334675
183Coxa vara (HP:0002812)1.65867697
184Broad distal phalanx of finger (HP:0009836)1.65629092
185Abnormal hair laboratory examination (HP:0003328)1.61812864
186Cholecystitis (HP:0001082)1.61212896
187Abnormal gallbladder physiology (HP:0012438)1.61212896
188Ragged-red muscle fibers (HP:0003200)1.60983836
189Abnormality of the acetabulum (HP:0003170)1.59439690
190Overriding aorta (HP:0002623)1.57703802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.94139902
2MAPK154.95951114
3DDR24.59397142
4MAP3K64.36767481
5IRAK34.03994248
6MAP3K113.80995798
7SIK13.79638777
8MST1R3.22829333
9MATK3.05251430
10PIM22.90658385
11PINK12.89379837
12SMG12.79038585
13FGR2.72969733
14TYRO32.63406863
15TESK12.52965123
16PRKD22.39392541
17DAPK12.15544146
18UHMK12.14864756
19BMX2.12393807
20LMTK22.06433714
21CSK2.04290276
22DYRK1B1.88169825
23YES11.87700155
24CDK71.83547726
25TTN1.74453276
26PDGFRA1.71644340
27PKN21.66784158
28PIM11.64768127
29MET1.62569139
30MAP3K101.46914196
31ARAF1.45816073
32TRPM71.36704276
33DYRK31.26373330
34MAPK111.22607557
35RPS6KC11.22158952
36RPS6KL11.22158952
37SCYL21.20528150
38CDK61.20437192
39LIMK11.13768060
40AKT31.13192198
41MAP3K31.12449360
42PTK61.12353660
43LATS21.09752912
44RPS6KA61.08069305
45GSK3A1.05821233
46CHEK21.02483563
47BUB10.97477297
48EPHB10.96387448
49TRIB30.95252899
50TLK10.95113293
51MAP2K30.93734614
52MAPKAPK30.93602420
53ILK0.92168899
54IRAK20.92161713
55FGFR40.89052218
56VRK20.88621904
57HIPK20.88226088
58CDC42BPA0.88134649
59EPHB20.87669655
60TBK10.87414259
61PLK10.86099148
62PHKG10.83930874
63PHKG20.83930874
64NTRK10.81832839
65MAP4K10.80682661
66PRKD30.78028344
67IRAK40.77183406
68ABL20.77158985
69TAOK20.74847673
70BRAF0.70486806
71PRKG20.70172374
72RPS6KA20.69503658
73RPS6KA10.68130834
74KDR0.68086419
75MTOR0.68027071
76RAF10.65122249
77RIPK10.64385355
78SIK30.63288607
79MAP3K10.63031513
80ERBB40.62630088
81STK100.59284733
82LRRK20.59087728
83NEK20.59003883
84MUSK0.58604302
85PRPF4B0.58027574
86WNK30.57727905
87TAOK10.55955672
88LYN0.55712197
89NME20.55703020
90PDPK10.55126219
91PRKAA10.54629917
92RPS6KB20.52479052
93GRK60.50342723
94CDC70.50118007
95ATR0.46710370
96MAPK40.46011086
97CDK20.45340206
98AURKA0.44850356
99CSNK2A10.44109391
100MOS0.43404552
101PBK0.43403834
102MAP3K130.43013459
103EPHA20.41494707
104CSNK1G10.40739602
105PAK20.40456543
106BLK0.40313960
107STK30.40011429
108EGFR0.39965139
109STK380.38628946
110WEE10.38503685
111MAPK30.37796437
112MAP2K20.36594408
113DAPK30.36400443
114KSR20.35810848
115RPS6KA40.35701937
116TESK20.35345551
117CSNK2A20.35128250
118AKT20.33922521
119ERN10.33616955
120CDK40.33573969
121LCK0.32515565
122FLT30.32470732
123CDK120.32279304
124CDK80.31191427
125CHUK0.30323549
126MAP3K90.29187459
127MAPKAPK20.28894277
128MAP3K140.28753699
129MAPK10.28692362
130PAK10.28214603
131EIF2AK10.27323323
132BCKDK0.27016030
133PRKCI0.26811645
134PDGFRB0.26298753
135RPS6KB10.26232115
136ZAP700.26176008
137AURKB0.25555727
138MAP3K80.24885278
139MARK20.24358584
140TNK20.24304310
141ALK0.24235890
142EEF2K0.24099814
143ROCK20.24029034
144DYRK20.23864385
145CAMK2G0.23763387
146PTK20.23719878
147MST40.23703402
148CHEK10.23533182
149PAK40.22876025
150CAMK2B0.22586649

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.06800348
2Mismatch repair_Homo sapiens_hsa034304.78486720
3Base excision repair_Homo sapiens_hsa034104.66355264
4DNA replication_Homo sapiens_hsa030304.24800816
5Other glycan degradation_Homo sapiens_hsa005113.01943533
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.87377595
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43632449
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.36858167
9Nucleotide excision repair_Homo sapiens_hsa034202.34061332
10Sulfur relay system_Homo sapiens_hsa041222.25795710
11Arginine and proline metabolism_Homo sapiens_hsa003302.19804540
12Folate biosynthesis_Homo sapiens_hsa007902.07098313
13Homologous recombination_Homo sapiens_hsa034401.98987059
14Spliceosome_Homo sapiens_hsa030401.96405203
15Ribosome_Homo sapiens_hsa030101.88374543
16RNA transport_Homo sapiens_hsa030131.85010299
17Vibrio cholerae infection_Homo sapiens_hsa051101.72307633
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69531828
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61950540
20Biosynthesis of amino acids_Homo sapiens_hsa012301.61468986
21Notch signaling pathway_Homo sapiens_hsa043301.61454604
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57138985
23mRNA surveillance pathway_Homo sapiens_hsa030151.56159235
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52172956
25p53 signaling pathway_Homo sapiens_hsa041151.50965884
26Fanconi anemia pathway_Homo sapiens_hsa034601.50893464
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42486427
28Cell cycle_Homo sapiens_hsa041101.40694362
29Fatty acid metabolism_Homo sapiens_hsa012121.39967618
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37490507
31Hippo signaling pathway_Homo sapiens_hsa043901.37340196
32Primary immunodeficiency_Homo sapiens_hsa053401.34170344
33Hedgehog signaling pathway_Homo sapiens_hsa043401.33261305
34ECM-receptor interaction_Homo sapiens_hsa045121.32528925
35mTOR signaling pathway_Homo sapiens_hsa041501.31295158
36Focal adhesion_Homo sapiens_hsa045101.30698026
37Circadian rhythm_Homo sapiens_hsa047101.29595134
38Prion diseases_Homo sapiens_hsa050201.25601625
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.22163172
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20186853
41Bladder cancer_Homo sapiens_hsa052191.16743396
42Shigellosis_Homo sapiens_hsa051311.16587484
43Pancreatic cancer_Homo sapiens_hsa052121.16415710
44Proteoglycans in cancer_Homo sapiens_hsa052051.14989977
45Galactose metabolism_Homo sapiens_hsa000521.14354972
46Apoptosis_Homo sapiens_hsa042101.13866551
47Fructose and mannose metabolism_Homo sapiens_hsa000511.10735048
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09745983
49Non-small cell lung cancer_Homo sapiens_hsa052231.07886765
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04336141
51Salmonella infection_Homo sapiens_hsa051321.02953248
52Hepatitis C_Homo sapiens_hsa051600.98964133
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.97402635
54Vitamin B6 metabolism_Homo sapiens_hsa007500.97192772
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96788177
56Adherens junction_Homo sapiens_hsa045200.96641937
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.96440943
58Lysine degradation_Homo sapiens_hsa003100.96148590
59Carbon metabolism_Homo sapiens_hsa012000.94196035
60Endometrial cancer_Homo sapiens_hsa052130.93339818
61TGF-beta signaling pathway_Homo sapiens_hsa043500.90449289
62Glutathione metabolism_Homo sapiens_hsa004800.90307232
63One carbon pool by folate_Homo sapiens_hsa006700.89628928
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88009513
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87352521
66Amoebiasis_Homo sapiens_hsa051460.84173291
67VEGF signaling pathway_Homo sapiens_hsa043700.83551119
68Sphingolipid metabolism_Homo sapiens_hsa006000.83001491
69Endocytosis_Homo sapiens_hsa041440.81354502
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80312900
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.80262866
72Renal cell carcinoma_Homo sapiens_hsa052110.77840451
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77168780
74Proteasome_Homo sapiens_hsa030500.76411385
75RNA polymerase_Homo sapiens_hsa030200.75339028
76TNF signaling pathway_Homo sapiens_hsa046680.74872586
77Pyrimidine metabolism_Homo sapiens_hsa002400.73883260
78Wnt signaling pathway_Homo sapiens_hsa043100.72447556
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72074563
80Glioma_Homo sapiens_hsa052140.70568835
81ErbB signaling pathway_Homo sapiens_hsa040120.68941912
82Basal cell carcinoma_Homo sapiens_hsa052170.68902665
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.67796898
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67413559
85Mineral absorption_Homo sapiens_hsa049780.65713135
86Toxoplasmosis_Homo sapiens_hsa051450.64363307
87Fat digestion and absorption_Homo sapiens_hsa049750.62851469
88Acute myeloid leukemia_Homo sapiens_hsa052210.61982257
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60355977
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60059653
91Thyroid cancer_Homo sapiens_hsa052160.59344007
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58689097
93Legionellosis_Homo sapiens_hsa051340.58394203
94Colorectal cancer_Homo sapiens_hsa052100.57834108
95Steroid biosynthesis_Homo sapiens_hsa001000.55949584
96Prostate cancer_Homo sapiens_hsa052150.55792342
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55146484
98Renin-angiotensin system_Homo sapiens_hsa046140.54982249
99Vitamin digestion and absorption_Homo sapiens_hsa049770.54945793
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53865246
101Sulfur metabolism_Homo sapiens_hsa009200.53340422
102Influenza A_Homo sapiens_hsa051640.52934034
103Arginine biosynthesis_Homo sapiens_hsa002200.52760905
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51853420
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.50935977
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50061996
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49357530
108Oocyte meiosis_Homo sapiens_hsa041140.48969783
109Choline metabolism in cancer_Homo sapiens_hsa052310.48741410
110Chronic myeloid leukemia_Homo sapiens_hsa052200.48678751
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48523389
112Selenocompound metabolism_Homo sapiens_hsa004500.48318492
113Melanoma_Homo sapiens_hsa052180.47886309
114Viral carcinogenesis_Homo sapiens_hsa052030.47761027
115Pathways in cancer_Homo sapiens_hsa052000.46607843
116Herpes simplex infection_Homo sapiens_hsa051680.45987709
117Insulin resistance_Homo sapiens_hsa049310.45934091
118N-Glycan biosynthesis_Homo sapiens_hsa005100.45704035
119Pentose phosphate pathway_Homo sapiens_hsa000300.45635242
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45386173
121Fatty acid elongation_Homo sapiens_hsa000620.44150069
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43668219
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.43125183
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43066717
125MicroRNAs in cancer_Homo sapiens_hsa052060.41963261
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41251300
127Tight junction_Homo sapiens_hsa045300.40833540
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40647262
129Basal transcription factors_Homo sapiens_hsa030220.40284018
130Small cell lung cancer_Homo sapiens_hsa052220.40115272
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35811510
132Epstein-Barr virus infection_Homo sapiens_hsa051690.34128723
133Viral myocarditis_Homo sapiens_hsa054160.34029076
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32472427
135AMPK signaling pathway_Homo sapiens_hsa041520.31559648
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31377059
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.31040341
138RNA degradation_Homo sapiens_hsa030180.30961589
139Lysosome_Homo sapiens_hsa041420.30934746
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28075734
141Glycerolipid metabolism_Homo sapiens_hsa005610.26348674
142B cell receptor signaling pathway_Homo sapiens_hsa046620.26182398
143Hepatitis B_Homo sapiens_hsa051610.23699661
144HTLV-I infection_Homo sapiens_hsa051660.22026313
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.21267695
146Metabolic pathways_Homo sapiens_hsa011000.20218059
147Insulin signaling pathway_Homo sapiens_hsa049100.19665714
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19089270

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