SLC52A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a riboflavin transporter protein that is strongly expressed in the intestine and likely plays a role in intestinal absorption of riboflavin. The protein is predicted to have eleven transmembrane domains and a cell surface localization signal in the C-terminus. Mutations at this locus have been associated with Brown-Vialetto-Van Laere syndrome and Fazio-Londe disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.95489482
2piRNA metabolic process (GO:0034587)5.87344499
3positive regulation of male gonad development (GO:2000020)5.67561787
4regulation of meiosis I (GO:0060631)5.56644034
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.55866879
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.55866879
7regulation of guanylate cyclase activity (GO:0031282)5.54017496
8sex determination (GO:0007530)5.39809566
9antigen processing and presentation of endogenous antigen (GO:0019883)4.98186605
10gonadal mesoderm development (GO:0007506)4.80280076
11regulation of male gonad development (GO:2000018)4.71525672
12synaptonemal complex assembly (GO:0007130)4.62347095
13L-fucose catabolic process (GO:0042355)4.60268583
14fucose catabolic process (GO:0019317)4.60268583
15L-fucose metabolic process (GO:0042354)4.60268583
16positive regulation of guanylate cyclase activity (GO:0031284)4.57788854
17sex differentiation (GO:0007548)4.48910525
18antigen processing and presentation via MHC class Ib (GO:0002475)4.48770978
19negative regulation of metanephros development (GO:0072217)4.34031726
20short-chain fatty acid metabolic process (GO:0046459)4.32746348
21synaptonemal complex organization (GO:0070193)4.29829297
22plasma membrane fusion (GO:0045026)4.27686852
23quinone biosynthetic process (GO:1901663)4.26284720
24male meiosis (GO:0007140)3.96319906
25positive regulation of respiratory burst (GO:0060267)3.93488392
26vitamin transmembrane transport (GO:0035461)3.92974288
27oocyte development (GO:0048599)3.84198518
28flavonoid metabolic process (GO:0009812)3.80338361
29drug transmembrane transport (GO:0006855)3.73029028
30anatomical structure regression (GO:0060033)3.70697492
31poly(A)+ mRNA export from nucleus (GO:0016973)3.70066201
32DNA methylation involved in gamete generation (GO:0043046)3.63039165
33glomerular basement membrane development (GO:0032836)3.62228682
34phosphatidylinositol acyl-chain remodeling (GO:0036149)3.56852044
35regulation of gonadotropin secretion (GO:0032276)3.51939937
36male sex determination (GO:0030238)3.51868737
37epoxygenase P450 pathway (GO:0019373)3.51478654
38angiotensin maturation (GO:0002003)3.50945422
39apoptotic cell clearance (GO:0043277)3.47974198
40adhesion of symbiont to host (GO:0044406)3.40873537
41nucleotide transmembrane transport (GO:1901679)3.39924248
42phosphatidylserine acyl-chain remodeling (GO:0036150)3.32491835
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.32312826
44calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.31628831
45transepithelial transport (GO:0070633)3.29446370
46morphogenesis of an endothelium (GO:0003159)3.29263668
47endothelial tube morphogenesis (GO:0061154)3.29263668
48fucosylation (GO:0036065)3.25511806
49fat-soluble vitamin biosynthetic process (GO:0042362)3.25223620
50drug metabolic process (GO:0017144)3.23869563
51cellular response to interferon-alpha (GO:0035457)3.22554360
52regulation of cGMP biosynthetic process (GO:0030826)3.22124911
53digestion (GO:0007586)3.19132787
54ubiquinone biosynthetic process (GO:0006744)3.18812529
55cellular response to gonadotropin stimulus (GO:0071371)3.18239052
56glucuronate metabolic process (GO:0019585)3.17972990
57uronic acid metabolic process (GO:0006063)3.17972990
58ketone biosynthetic process (GO:0042181)3.17801052
59bundle of His cell to Purkinje myocyte communication (GO:0086069)3.15961476
60cellular glucuronidation (GO:0052695)3.15685852
61negative regulation of epidermal cell differentiation (GO:0045605)3.15378981
62virion attachment to host cell (GO:0019062)3.14378106
63adhesion of symbiont to host cell (GO:0044650)3.14378106
64phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.14359995
65homocysteine metabolic process (GO:0050667)3.12713203
66interferon-gamma secretion (GO:0072643)3.12111201
67arginine metabolic process (GO:0006525)3.11167866
68NADH metabolic process (GO:0006734)3.10662843
69drug transport (GO:0015893)3.10096110
70hypotonic response (GO:0006971)3.07437020
71regulation of bile acid biosynthetic process (GO:0070857)3.06505595
72sulfation (GO:0051923)3.06152637
73natural killer cell differentiation (GO:0001779)3.05951031
74trophectodermal cell differentiation (GO:0001829)3.04196156
75heme transport (GO:0015886)3.02282651
76regulation of water loss via skin (GO:0033561)3.01418626
77cytidine deamination (GO:0009972)3.00746426
78cytidine metabolic process (GO:0046087)3.00746426
79cytidine catabolic process (GO:0006216)3.00746426
80cobalamin metabolic process (GO:0009235)2.99839940
81negative regulation of kidney development (GO:0090185)2.98942224
82cellular response to thyroid hormone stimulus (GO:0097067)2.98046962
83negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.97987168
84cardiac right ventricle morphogenesis (GO:0003215)2.95450880
85* vitamin transport (GO:0051180)2.91764389
86renal system process involved in regulation of blood volume (GO:0001977)2.90951741
87drug catabolic process (GO:0042737)2.90852747
88positive regulation of macrophage cytokine production (GO:0060907)2.90309732
89sulfur compound transport (GO:0072348)2.89991337
90macroautophagy (GO:0016236)2.88929092
91regulation of interleukin-12 biosynthetic process (GO:0045075)2.87296020
92exogenous drug catabolic process (GO:0042738)2.87224956
93intestinal epithelial cell development (GO:0060576)2.86756582
94glomerulus development (GO:0032835)2.86668036
95alkaloid metabolic process (GO:0009820)2.84810642
96hemidesmosome assembly (GO:0031581)2.84770328
97bile acid and bile salt transport (GO:0015721)2.84001937
98quinone metabolic process (GO:1901661)2.83968960
993-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.83464948
100purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.83464948
101glutathione biosynthetic process (GO:0006750)2.83331507
102receptor guanylyl cyclase signaling pathway (GO:0007168)2.83124935
103positive regulation of fatty acid transport (GO:2000193)2.82629670
104ubiquinone metabolic process (GO:0006743)2.82555895
105establishment of skin barrier (GO:0061436)2.79855622
106respiratory chain complex IV assembly (GO:0008535)2.76972509
107glycerol metabolic process (GO:0006071)2.76203054
108positive regulation of icosanoid secretion (GO:0032305)2.75706486
109meiotic nuclear division (GO:0007126)2.73272450
110response to thyroid hormone (GO:0097066)2.72218756
111positive regulation of prostaglandin secretion (GO:0032308)2.71590130
112chromosome organization involved in meiosis (GO:0070192)2.69617673
113sulfate transmembrane transport (GO:1902358)2.69366510
114nonribosomal peptide biosynthetic process (GO:0019184)2.66976805
115intestinal absorption (GO:0050892)2.66092226
116regulation of respiratory burst (GO:0060263)2.66085403
117regulation of systemic arterial blood pressure by hormone (GO:0001990)2.66068772
118regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.66068772
119endocrine process (GO:0050886)2.66068772
120phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.66025220
121positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.66002662
122regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.66002662
123regulation of triglyceride catabolic process (GO:0010896)2.65082178
124negative regulation of epidermis development (GO:0045683)2.64567805
125peptide catabolic process (GO:0043171)2.64372583
126diol metabolic process (GO:0034311)2.63818536
127germ cell migration (GO:0008354)2.63781417
128mannosylation (GO:0097502)2.63546610
129regulation of cell proliferation involved in kidney development (GO:1901722)2.63492385
130hepatocyte apoptotic process (GO:0097284)2.63017434
131negative regulation of meiosis (GO:0045835)2.62188083
132striated muscle atrophy (GO:0014891)2.61700678
133basement membrane organization (GO:0071711)2.61526345
134male meiosis I (GO:0007141)2.61143780
135epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61018276
136proline biosynthetic process (GO:0006561)2.60017476
137embryonic foregut morphogenesis (GO:0048617)2.59796220
138negative regulation of erythrocyte differentiation (GO:0045647)2.58703120
139sphingoid metabolic process (GO:0046519)2.57902196
140DNA deamination (GO:0045006)2.57808082
141fat-soluble vitamin metabolic process (GO:0006775)2.57719887
142GDP-mannose metabolic process (GO:0019673)2.57243757
143regulation of mesenchymal cell apoptotic process (GO:2001053)2.56879160
144phosphatidylcholine acyl-chain remodeling (GO:0036151)2.55673810
145regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.55037048
146regulation of protein glycosylation (GO:0060049)2.54983350
147regulation of cGMP metabolic process (GO:0030823)2.54108802
148epithelial cell-cell adhesion (GO:0090136)2.53973882
149regulation of RIG-I signaling pathway (GO:0039535)2.53971727
150regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.53523937
151alditol metabolic process (GO:0019400)2.52013773
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.51907985
153positive regulation of natural killer cell differentiation (GO:0032825)2.51784742
154phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.51520382
155vitamin A metabolic process (GO:0006776)2.51458022
156positive regulation of antigen processing and presentation (GO:0002579)2.50508390
157histone H4-K12 acetylation (GO:0043983)2.48311898
158surfactant homeostasis (GO:0043129)2.45992519
159modified amino acid transport (GO:0072337)2.45168714
160natural killer cell activation involved in immune response (GO:0002323)2.44610389
161response to misfolded protein (GO:0051788)2.40772859
162negative regulation of macrophage differentiation (GO:0045650)2.40324830
163natural killer cell activation (GO:0030101)2.38891926
164positive regulation of pseudopodium assembly (GO:0031274)2.38890624
165regulation of cardioblast differentiation (GO:0051890)2.37254522
166gene silencing by RNA (GO:0031047)2.36342601
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.33903289
168regulation of MHC class I biosynthetic process (GO:0045343)2.31822076
169desmosome organization (GO:0002934)2.31539180
170regulation of protein import into nucleus, translocation (GO:0033158)2.31512192
171positive regulation of protein import into nucleus, translocation (GO:0033160)2.30999102
172negative regulation of interferon-gamma production (GO:0032689)2.30850246
173regulation of cholesterol storage (GO:0010885)2.29750969
174renal absorption (GO:0070293)2.28717785
175female genitalia development (GO:0030540)2.28585127
176pinocytosis (GO:0006907)2.27883944
177establishment of endothelial barrier (GO:0061028)2.24281434
178histone H4-K8 acetylation (GO:0043982)2.22534921
179histone H4-K5 acetylation (GO:0043981)2.22534921
180oogenesis (GO:0048477)2.21759216
181growth hormone receptor signaling pathway (GO:0060396)2.21714649
182regulation of podosome assembly (GO:0071801)2.20155665
183dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.19187944
184skeletal muscle adaptation (GO:0043501)2.17997853
185Leydig cell differentiation (GO:0033327)2.15602012
186meiosis I (GO:0007127)2.14682878
187glial cell proliferation (GO:0014009)2.14594261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.60558463
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.56232585
3VDR_22108803_ChIP-Seq_LS180_Human3.35906006
4ZNF274_21170338_ChIP-Seq_K562_Hela3.34883788
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.88883625
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.83390135
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.83390135
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.83390135
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.48788537
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.45373144
11ZNF263_19887448_ChIP-Seq_K562_Human2.43223177
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41135565
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.28622913
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20706965
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.19433765
16GATA1_22025678_ChIP-Seq_K562_Human2.18154580
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13868368
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97185889
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94284827
20FOXA1_27270436_Chip-Seq_PROSTATE_Human1.90769621
21FOXA1_25329375_ChIP-Seq_VCAP_Human1.90769621
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86941351
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.85650526
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80680706
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.80296788
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74914148
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.73641583
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70021709
29RACK7_27058665_Chip-Seq_MCF-7_Human1.69667470
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69536471
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.68636758
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.67586827
33CLOCK_20551151_ChIP-Seq_293T_Human1.66717473
34GATA4_25053715_ChIP-Seq_YYC3_Human1.66277806
35HOXB7_26014856_ChIP-Seq_BT474_Human1.66193385
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65193847
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64373587
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64034532
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61521324
40AR_20517297_ChIP-Seq_VCAP_Human1.55694235
41TCF7_22412390_ChIP-Seq_EML_Mouse1.54915738
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53967669
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.53747367
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53069744
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52831833
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.50390512
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49397636
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49345579
49CDX2_22108803_ChIP-Seq_LS180_Human1.49340459
50MAF_26560356_Chip-Seq_TH1_Human1.48709716
51NANOG_20526341_ChIP-Seq_ESCs_Human1.48629450
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.48100383
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47645696
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46877851
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.45662001
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45194721
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.44670342
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44374484
59GATA6_25053715_ChIP-Seq_YYC3_Human1.43857431
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43476922
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42241078
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.39998542
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38808079
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38441272
65TP53_22573176_ChIP-Seq_HFKS_Human1.37823698
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.37453516
67ERA_21632823_ChIP-Seq_H3396_Human1.37119003
68ATF3_27146783_Chip-Seq_COLON_Human1.36948372
69P53_21459846_ChIP-Seq_SAOS-2_Human1.35587541
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34901919
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.34848576
72PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34795370
73FOXH1_21741376_ChIP-Seq_ESCs_Human1.34221413
74NCOR_22424771_ChIP-Seq_293T_Human1.33862599
75P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32969128
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32157579
77OCT4_20526341_ChIP-Seq_ESCs_Human1.30460028
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30211567
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.29484459
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27636766
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27245424
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26185593
83BCAT_22108803_ChIP-Seq_LS180_Human1.26000349
84SOX2_20726797_ChIP-Seq_SW620_Human1.25977264
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.25720862
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23617484
87TCF4_22108803_ChIP-Seq_LS180_Human1.23457333
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.23350196
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22565676
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22258278
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22258278
92LXR_22292898_ChIP-Seq_THP-1_Human1.22205534
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22122317
94NCOR1_26117541_ChIP-Seq_K562_Human1.21916579
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21890370
96IRF8_27001747_Chip-Seq_BMDM_Mouse1.21679196
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.19934716
98MYC_19829295_ChIP-Seq_ESCs_Human1.19209258
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18540853
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18333202
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17652779
102STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17285328
103EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16859241
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16808535
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16261655
106MYB_26560356_Chip-Seq_TH1_Human1.16249046
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16246324
108IRF1_19129219_ChIP-ChIP_H3396_Human1.15776425
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15480124
110MYB_26560356_Chip-Seq_TH2_Human1.14894861
111SOX2_19829295_ChIP-Seq_ESCs_Human1.14508317
112NANOG_19829295_ChIP-Seq_ESCs_Human1.14508317
113TAF2_19829295_ChIP-Seq_ESCs_Human1.14221389
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12964371
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12033416
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11543249
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11051774
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11030962
119KDM2B_26808549_Chip-Seq_DND41_Human1.10984962
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10782690
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10467838
122FOXA1_25552417_ChIP-Seq_VCAP_Human1.10421477
123PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10395665
124JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10215226
125CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09299966
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09116784
127KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09048843
128PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08886681
129GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08605206
130UTX_26944678_Chip-Seq_JUKART_Human1.08014096
131ELF5_23300383_ChIP-Seq_T47D_Human1.07772733
132TP53_22127205_ChIP-Seq_IMR90_Human1.06746515
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06072066
134KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04978544
135RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04261937
136NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04191900
137RXR_22158963_ChIP-Seq_LIVER_Mouse1.03654369
138P300_27268052_Chip-Seq_Bcells_Human1.02580709
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02406314
140CEBPB_22108803_ChIP-Seq_LS180_Human1.02066877
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01616860
142STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01473824
143IGF1R_20145208_ChIP-Seq_DFB_Human1.01418583
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01054667
145BCL6_27268052_Chip-Seq_Bcells_Human0.99591943
146EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99263561
147GATA1_19941826_ChIP-Seq_K562_Human0.98813229
148AR_21909140_ChIP-Seq_LNCAP_Human0.98604275
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97072151
150RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96571978
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95886180
152ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95665361
153ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95580726
154CTCF_20526341_ChIP-Seq_ESCs_Human0.95463188
155P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94739596
156E2F1_20622854_ChIP-Seq_HELA_Human0.94709661
157GATA2_19941826_ChIP-Seq_K562_Human0.94477026
158SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94239844
159VDR_21846776_ChIP-Seq_THP-1_Human0.93782382
160BCOR_27268052_Chip-Seq_Bcells_Human0.93546149
161RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93457813
162GATA3_24758297_ChIP-Seq_MCF-7_Human0.93399647
163CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93272549
164BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93012259
165AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92492237
166OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91809999
167SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91555687
168ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91489941
169FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91308510
170RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91140261
171ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90602729
172PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90600818
173EST1_17652178_ChIP-ChIP_JURKAT_Human0.90165955
174SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90150939
175PHF8_20622854_ChIP-Seq_HELA_Human0.90109879
176PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89795289
177FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89539608
178MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89420066
179KLF5_25053715_ChIP-Seq_YYC3_Human0.89300744
180GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88916000
181CREB1_26743006_Chip-Seq_LNCaP_Human0.88727325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.43921216
2MP0003878_abnormal_ear_physiology4.43921216
3MP0008995_early_reproductive_senescence4.20274751
4MP0005085_abnormal_gallbladder_physiolo3.10581769
5MP0005365_abnormal_bile_salt2.98714697
6MP0010234_abnormal_vibrissa_follicle2.95011093
7MP0008877_abnormal_DNA_methylation2.70945933
8MP0005670_abnormal_white_adipose2.49561232
9MP0003866_abnormal_defecation2.29608562
10MP0008875_abnormal_xenobiotic_pharmacok2.26303413
11MP0001664_abnormal_digestion2.23526326
12MP0006054_spinal_hemorrhage2.23122269
13MP0003786_premature_aging2.20621543
14MP0008872_abnormal_physiological_respon2.19194525
15MP0002876_abnormal_thyroid_physiology2.18547298
16MP0002139_abnormal_hepatobiliary_system2.13805482
17MP0003300_gastrointestinal_ulcer2.13171668
18MP0002796_impaired_skin_barrier2.08605274
19MP0004264_abnormal_extraembryonic_tissu2.07063109
20MP0004043_abnormal_pH_regulation2.06968683
21MP0003724_increased_susceptibility_to2.04586080
22MP0005167_abnormal_blood-brain_barrier2.00772897
23MP0001764_abnormal_homeostasis1.92609029
24MP0002736_abnormal_nociception_after1.76012952
25MP0005360_urolithiasis1.75097648
26MP0004947_skin_inflammation1.74301491
27MP0003718_maternal_effect1.74230098
28MP0004147_increased_porphyrin_level1.73372178
29MP0003806_abnormal_nucleotide_metabolis1.70833314
30MP0010352_gastrointestinal_tract_polyps1.70463627
31MP0002254_reproductive_system_inflammat1.70217937
32MP0001873_stomach_inflammation1.68341631
33MP0001765_abnormal_ion_homeostasis1.67788931
34MP0001958_emphysema1.65717507
35MP0001968_abnormal_touch/_nociception1.64626305
36MP0005332_abnormal_amino_acid1.64449537
37MP0009840_abnormal_foam_cell1.60798100
38MP0003045_fibrosis1.58942813
39MP0001485_abnormal_pinna_reflex1.57695557
40MP0000538_abnormal_urinary_bladder1.55944626
41MP0005367_renal/urinary_system_phenotyp1.54720459
42MP0000516_abnormal_urinary_system1.54720459
43MP0010329_abnormal_lipoprotein_level1.52682844
44MP0005076_abnormal_cell_differentiation1.52226043
45MP0000427_abnormal_hair_cycle1.49468141
46MP0004272_abnormal_basement_membrane1.47861358
47MP0001919_abnormal_reproductive_system1.46729616
48MP0005501_abnormal_skin_physiology1.44486370
49MP0009278_abnormal_bone_marrow1.43833060
50MP0010155_abnormal_intestine_physiology1.40628079
51MP0005310_abnormal_salivary_gland1.39698256
52MP0003705_abnormal_hypodermis_morpholog1.39505842
53MP0005636_abnormal_mineral_homeostasis1.39351296
54MP0005410_abnormal_fertilization1.38766652
55MP0000566_synostosis1.35545498
56MP0005646_abnormal_pituitary_gland1.35332316
57MP0001835_abnormal_antigen_presentation1.35203111
58MP0000537_abnormal_urethra_morphology1.31837605
59MP0003453_abnormal_keratinocyte_physiol1.29051267
60MP0005645_abnormal_hypothalamus_physiol1.27764236
61MP0001727_abnormal_embryo_implantation1.27648968
62MP0003879_abnormal_hair_cell1.26256756
63MP0000685_abnormal_immune_system1.24018788
64MP0001666_abnormal_nutrient_absorption1.22841186
65MP0001188_hyperpigmentation1.21621949
66MP0001216_abnormal_epidermal_layer1.21381669
67MP0003315_abnormal_perineum_morphology1.20731945
68MP0001501_abnormal_sleep_pattern1.20676463
69MP0001661_extended_life_span1.20504402
70MP0004019_abnormal_vitamin_homeostasis1.19137359
71MP0006082_CNS_inflammation1.17815393
72MP0005647_abnormal_sex_gland1.17379176
73MP0003195_calcinosis1.16697418
74MP0002148_abnormal_hypersensitivity_rea1.16491894
75MP0002166_altered_tumor_susceptibility1.15627176
76MP0005397_hematopoietic_system_phenotyp1.15403539
77MP0001545_abnormal_hematopoietic_system1.15403539
78MP0002138_abnormal_hepatobiliary_system1.14729565
79MP0003566_abnormal_cell_adhesion1.13687174
80MP0003828_pulmonary_edema1.13153805
81MP0000490_abnormal_crypts_of1.12435982
82MP0009384_cardiac_valve_regurgitation1.11712348
83MP0002822_catalepsy1.10426113
84MP0004957_abnormal_blastocyst_morpholog1.09964438
85MP0005389_reproductive_system_phenotype1.09887277
86MP0004782_abnormal_surfactant_physiolog1.09871498
87MP0003191_abnormal_cellular_cholesterol1.09785256
88MP0002210_abnormal_sex_determination1.09053024
89MP0003941_abnormal_skin_development1.08720310
90MP0001145_abnormal_male_reproductive1.08666251
91MP0002098_abnormal_vibrissa_morphology1.08334261
92MP0009643_abnormal_urine_homeostasis1.07079371
93MP0010678_abnormal_skin_adnexa1.06534995
94MP0003638_abnormal_response/metabolism_1.05042634
95MP0008004_abnormal_stomach_pH1.04639572
96MP0002136_abnormal_kidney_physiology1.03469255
97MP0002009_preneoplasia1.01693562
98MP0005551_abnormal_eye_electrophysiolog1.00983402
99MP0002006_tumorigenesis0.98157242
100MP0001849_ear_inflammation0.97999936
101MP0001929_abnormal_gametogenesis0.97721338
102MP0003436_decreased_susceptibility_to0.96678389
103MP0004885_abnormal_endolymph0.96409918
104MP0005671_abnormal_response_to0.95585150
105MP0004133_heterotaxia0.95453756
106MP0003183_abnormal_peptide_metabolism0.95112512
107MP0003936_abnormal_reproductive_system0.94632890
108MP0000467_abnormal_esophagus_morphology0.94112882
109MP0001881_abnormal_mammary_gland0.93107574
110MP0003119_abnormal_digestive_system0.93001085
111MP0005025_abnormal_response_to0.92977163
112MP0001851_eye_inflammation0.91536739
113MP0009785_altered_susceptibility_to0.89898280
114MP0002452_abnormal_antigen_presenting0.89590627
115MP0000465_gastrointestinal_hemorrhage0.89070263
116MP0000230_abnormal_systemic_arterial0.88794925
117MP0001756_abnormal_urination0.88654885
118MP0000462_abnormal_digestive_system0.87484116
119MP0002102_abnormal_ear_morphology0.86797712
120MP0000470_abnormal_stomach_morphology0.86537086
121MP0000383_abnormal_hair_follicle0.84798222
122MP0001819_abnormal_immune_cell0.84696606
123MP0000678_abnormal_parathyroid_gland0.82223598
124MP0008057_abnormal_DNA_replication0.81324877
125MP0001663_abnormal_digestive_system0.81124853
126MP0002420_abnormal_adaptive_immunity0.81021956
127MP0002405_respiratory_system_inflammati0.79707687
128MP0000653_abnormal_sex_gland0.79627852
129MP0005058_abnormal_lysosome_morphology0.79615591
130MP0002118_abnormal_lipid_homeostasis0.79604309
131MP0001853_heart_inflammation0.78523476
132MP0000343_altered_response_to0.78424734
133MP0005387_immune_system_phenotype0.77639164
134MP0001790_abnormal_immune_system0.77639164
135MP0003252_abnormal_bile_duct0.77479318
136MP0000477_abnormal_intestine_morphology0.76035342
137MP0009333_abnormal_splenocyte_physiolog0.76001552
138MP0005395_other_phenotype0.75881069
139MP0006138_congestive_heart_failure0.75775821
140MP0009379_abnormal_foot_pigmentation0.75679293
141MP0005464_abnormal_platelet_physiology0.74543878
142MP0003698_abnormal_male_reproductive0.74071701
143MP0005000_abnormal_immune_tolerance0.73774572
144MP0003763_abnormal_thymus_physiology0.73679646
145MP0002086_abnormal_extraembryonic_tissu0.73659637
146MP0003693_abnormal_embryo_hatching0.73054652
147MP0001845_abnormal_inflammatory_respons0.72520042
148MP0002419_abnormal_innate_immunity0.72316693
149MP0000627_abnormal_mammary_gland0.71207451
150MP0005448_abnormal_energy_balance0.71090983
151MP0005319_abnormal_enzyme/_coenzyme0.70433572
152MP0005381_digestive/alimentary_phenotyp0.68078165
153MP0002653_abnormal_ependyma_morphology0.65563563
154MP0005083_abnormal_biliary_tract0.65084467
155MP0002160_abnormal_reproductive_system0.65050397
156MP0004215_abnormal_myocardial_fiber0.63622142
157MP0002272_abnormal_nervous_system0.63360084
158MP0002733_abnormal_thermal_nociception0.63111075
159MP0001986_abnormal_taste_sensitivity0.62389093

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.33850029
2Gonadal dysgenesis (HP:0000133)5.74662629
3Gonadotropin excess (HP:0000837)4.61974273
411 pairs of ribs (HP:0000878)4.43312740
5Hyperglycinuria (HP:0003108)4.33411304
6Metaphyseal cupping (HP:0003021)4.22379335
7Abnormality of the nasal mucosa (HP:0000433)4.07431575
8Mesangial abnormality (HP:0001966)4.06636451
9Azoospermia (HP:0000027)3.72276887
10Abnormality of serine family amino acid metabolism (HP:0010894)3.62674821
11Abnormality of glycine metabolism (HP:0010895)3.62674821
12Decreased circulating renin level (HP:0003351)3.59343288
13Abnormality of the vitamin B12 metabolism (HP:0004341)3.54126250
14Nasal polyposis (HP:0100582)3.48598098
15Abnormality of vitamin B metabolism (HP:0004340)3.45094540
16Autoimmune hemolytic anemia (HP:0001890)3.43559414
17Polycythemia (HP:0001901)3.34449877
18Autoimmune thrombocytopenia (HP:0001973)3.32146391
19Abnormality of chloride homeostasis (HP:0011422)3.30978445
20True hermaphroditism (HP:0010459)3.26253229
21Pustule (HP:0200039)3.22322006
22Amelogenesis imperfecta (HP:0000705)3.20466043
23Abnormality of male internal genitalia (HP:0000022)3.17035275
24Abnormal sex determination (HP:0012244)3.15503085
25Sex reversal (HP:0012245)3.15503085
26Interstitial pulmonary disease (HP:0006530)3.11673016
27Male pseudohermaphroditism (HP:0000037)3.00212950
28Abnormality of renin-angiotensin system (HP:0000847)2.97653910
29Glycosuria (HP:0003076)2.97187304
30Abnormality of urine glucose concentration (HP:0011016)2.97187304
31Abnormal spermatogenesis (HP:0008669)2.92582472
32Hyperglycinemia (HP:0002154)2.86660625
33Hypoplasia of the uterus (HP:0000013)2.86436881
34Germ cell neoplasia (HP:0100728)2.84587295
35Vacuolated lymphocytes (HP:0001922)2.81088447
36Confusion (HP:0001289)2.80736604
37Rectal prolapse (HP:0002035)2.78354806
38Proximal tubulopathy (HP:0000114)2.74694939
39Esophageal varix (HP:0002040)2.73989632
40Abolished electroretinogram (ERG) (HP:0000550)2.68446030
41Missing ribs (HP:0000921)2.65343403
42Ileus (HP:0002595)2.63081037
43Abnormality of the renal cortex (HP:0011035)2.62054586
44Abnormality of vitamin metabolism (HP:0100508)2.58381122
45Dry hair (HP:0011359)2.57343806
46Metabolic alkalosis (HP:0200114)2.55111410
47Hematochezia (HP:0002573)2.54521838
48Renal cortical cysts (HP:0000803)2.53677210
49Gout (HP:0001997)2.52411617
50Testicular neoplasm (HP:0010788)2.50884886
51Right ventricular cardiomyopathy (HP:0011663)2.49835673
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46055373
53Chronic diarrhea (HP:0002028)2.45833277
54Congenital sensorineural hearing impairment (HP:0008527)2.44952774
55Alkalosis (HP:0001948)2.39408132
56Nausea (HP:0002018)2.37410203
57Lethargy (HP:0001254)2.35351100
58Acute encephalopathy (HP:0006846)2.34251934
59Hyperactive renin-angiotensin system (HP:0000841)2.31265023
60Abnormal hair laboratory examination (HP:0003328)2.29411320
61Micronodular cirrhosis (HP:0001413)2.26859123
62Secondary amenorrhea (HP:0000869)2.26366356
63Abnormality of the calcaneus (HP:0008364)2.26242716
64Hyperaldosteronism (HP:0000859)2.25481442
65Dicarboxylic aciduria (HP:0003215)2.25345125
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25345125
67Aortic aneurysm (HP:0004942)2.24653747
68Eczematoid dermatitis (HP:0000976)2.24515379
69Metabolic acidosis (HP:0001942)2.23632547
70Pancreatic cysts (HP:0001737)2.21824148
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21736031
72Osteolytic defects of the hand bones (HP:0009699)2.21512340
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.21512340
74Methylmalonic aciduria (HP:0012120)2.19937696
75Abnormality of macrophages (HP:0004311)2.19086567
76Selective tooth agenesis (HP:0001592)2.17908143
77Increased purine levels (HP:0004368)2.17623348
78Hyperuricemia (HP:0002149)2.17623348
79Congenital, generalized hypertrichosis (HP:0004540)2.16711889
80Myositis (HP:0100614)2.16532551
81Chronic otitis media (HP:0000389)2.16098861
82Focal segmental glomerulosclerosis (HP:0000097)2.15856985
83Fatigue (HP:0012378)2.15793550
84Pendular nystagmus (HP:0012043)2.15312162
85Congenital stationary night blindness (HP:0007642)2.15100885
86Tubular atrophy (HP:0000092)2.13806273
87Milia (HP:0001056)2.13532658
88Abnormal mitochondria in muscle tissue (HP:0008316)2.11697414
89Concave nail (HP:0001598)2.09968961
90Increased cerebral lipofuscin (HP:0011813)2.08618794
91Infertility (HP:0000789)2.08197625
92Tubulointerstitial nephritis (HP:0001970)2.06770274
93Degeneration of anterior horn cells (HP:0002398)2.06646909
94Abnormality of the anterior horn cell (HP:0006802)2.06646909
95Orchitis (HP:0100796)2.06579170
96Abnormality of the distal phalanges of the toes (HP:0010182)2.06574078
97Widely patent fontanelles and sutures (HP:0004492)2.05475968
98Hyperventilation (HP:0002883)2.05083573
99Megaloblastic anemia (HP:0001889)2.02700035
100Increased IgE level (HP:0003212)2.02186438
101Delayed CNS myelination (HP:0002188)2.01529318
102Pigmentary retinal degeneration (HP:0001146)2.00481105
103Aplasia/Hypoplasia of the tibia (HP:0005772)1.99364001
104Short tibia (HP:0005736)1.98079887
105Malnutrition (HP:0004395)1.97877917
106Glomerulosclerosis (HP:0000096)1.97687822
107Hyperammonemia (HP:0001987)1.96911014
108Hepatic necrosis (HP:0002605)1.94410538
109Elevated erythrocyte sedimentation rate (HP:0003565)1.94399654
110Abnormality of serum amino acid levels (HP:0003112)1.93778498
111Spinal muscular atrophy (HP:0007269)1.93733136
112Spontaneous hematomas (HP:0007420)1.90020281
113Generalized aminoaciduria (HP:0002909)1.89633804
114Loss of speech (HP:0002371)1.89179760
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89162361
116Renal salt wasting (HP:0000127)1.88267945
117Acute necrotizing encephalopathy (HP:0006965)1.87417108
118Premature loss of primary teeth (HP:0006323)1.87091905
119Abnormality of proline metabolism (HP:0010907)1.86916373
120Hydroxyprolinuria (HP:0003080)1.86916373
121Nonimmune hydrops fetalis (HP:0001790)1.86345467
122Premature ovarian failure (HP:0008209)1.85982356
123Emphysema (HP:0002097)1.85828888
124Stomach cancer (HP:0012126)1.85216585
125Severe muscular hypotonia (HP:0006829)1.84514319
126Abnormality of the 1st metacarpal (HP:0010009)1.84297861
127Abnormality of dental color (HP:0011073)1.83114592
128Alopecia of scalp (HP:0002293)1.82901968
129Woolly hair (HP:0002224)1.82640108
130IgM deficiency (HP:0002850)1.79161404
131Polyneuropathy (HP:0001271)1.78791060
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.78285824
133Type I transferrin isoform profile (HP:0003642)1.77780437
134Recurrent bronchitis (HP:0002837)1.77613877
135Type II lissencephaly (HP:0007260)1.76653030
136Mitochondrial inheritance (HP:0001427)1.76316709
137Abnormality of sulfur amino acid metabolism (HP:0004339)1.76194121
138Hypotrichosis (HP:0001006)1.75295046
139Vascular calcification (HP:0004934)1.74556639
140Abnormality of renal excretion (HP:0011036)1.74502793
141Molar tooth sign on MRI (HP:0002419)1.74489894
142Abnormality of midbrain morphology (HP:0002418)1.74489894
143Plantar hyperkeratosis (HP:0007556)1.74239675
144Abnormality of the proximal phalanges of the hand (HP:0009834)1.74063358
145Abnormality of the gastric mucosa (HP:0004295)1.74000582
146Colitis (HP:0002583)1.73721291
147Progressive inability to walk (HP:0002505)1.73013583
148Female pseudohermaphroditism (HP:0010458)1.72611324
149Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72220434
150Syncope (HP:0001279)1.71248886
151Tachypnea (HP:0002789)1.71050496
152Curly hair (HP:0002212)1.70791084
153Hypoalbuminemia (HP:0003073)1.70319241
154Abnormal albumin level (HP:0012116)1.70319241
155Abnormal glycosylation (HP:0012345)1.69934337
156Petechiae (HP:0000967)1.69802734
157Gingivitis (HP:0000230)1.69560065
158Anhidrosis (HP:0000970)1.68376266
159Recurrent abscess formation (HP:0002722)1.67248280
160Subacute progressive viral hepatitis (HP:0006572)1.66624855
161Onycholysis (HP:0001806)1.66590851
162IgA deficiency (HP:0002720)1.66343903
163Aplasia/hypoplasia of the uterus (HP:0008684)1.65995982
164Portal hypertension (HP:0001409)1.63281811
165Abnormality of glycolipid metabolism (HP:0010969)1.63128307
166Abnormality of liposaccharide metabolism (HP:0010968)1.63128307
167Abnormality of glycosphingolipid metabolism (HP:0004343)1.63128307
168Fragile nails (HP:0001808)1.62502172
169Thrombocytosis (HP:0001894)1.61330272
170Periodontitis (HP:0000704)1.60819268
171Pili torti (HP:0003777)1.59945612
172Thin bony cortex (HP:0002753)1.57949764
173Ankle contracture (HP:0006466)1.56838886
174Recurrent fungal infections (HP:0002841)1.55310524
175Short humerus (HP:0005792)1.54576988
176Nephritis (HP:0000123)1.54306480
177Hypoplasia of dental enamel (HP:0006297)1.53977990
178Abnormality of the hepatic vasculature (HP:0006707)1.53967977
179Cardiovascular calcification (HP:0011915)1.53316592
180Stage 5 chronic kidney disease (HP:0003774)1.52185947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.29257567
2CDK123.79228745
3MST43.18017373
4TIE13.01043634
5EPHA22.93916446
6OXSR12.63034430
7RIPK12.60399815
8FRK2.60028976
9TYRO32.57116479
10BMPR1B2.42253797
11ERN12.40815060
12ADRBK22.35235839
13INSRR2.22583461
14NME12.18326237
15MAP3K122.17313228
16PTK62.16150698
17STK102.15807526
18PINK12.11909271
19WNK42.05311306
20ZAK2.02654275
21WNK32.00855823
22PAK41.98625349
23EPHB11.93586266
24TRIB31.88147090
25TESK11.87333232
26MAP2K21.86447576
27MAP4K21.82367197
28PDK21.77546044
29KDR1.76302146
30TGFBR21.75413850
31ICK1.70840629
32TBK11.70036082
33TLK11.65340923
34BLK1.59905846
35MATK1.54795760
36TXK1.52815077
37MYLK1.51274089
38MST1R1.47192556
39PDK41.39624233
40PDK31.39624233
41AKT31.38049033
42NEK21.37959184
43MAP4K11.37328934
44NUAK11.35450790
45GRK61.35431080
46JAK31.33743041
47MAP3K141.28428487
48CDK71.25927000
49LRRK21.23186647
50FER1.20482227
51MAP3K31.20007183
52LMTK21.19482962
53PIK3CA1.15610645
54IKBKE1.14284810
55BMX1.12965846
56CDK91.11796870
57CSK1.10354095
58GRK11.08599910
59STK31.07215445
60EEF2K1.07194993
61PHKG21.07132861
62PHKG11.07132861
63MAP3K101.07100000
64MKNK21.04401277
65CHUK1.03523429
66PIM11.03150769
67EPHB21.03108650
68PRKD31.02595663
69TYK21.01904975
70PRKCE1.00091320
71CASK0.97640509
72TSSK60.97316261
73PIM20.96135679
74WNK10.95997868
75MAP2K60.95624592
76PTK20.94884885
77BCKDK0.94811059
78MAP3K20.94637627
79STK38L0.94366119
80RPS6KB20.93821459
81BRSK20.92715272
82CDK60.91292820
83CDK40.91196922
84MARK30.91164542
85TESK20.88957018
86LATS10.87768884
87RIPK40.85548495
88IKBKB0.84571573
89FGFR40.84218715
90VRK20.84192576
91STK240.84148829
92NEK10.80976833
93MAPK130.77792963
94TAOK30.77622436
95NEK90.75065043
96TGFBR10.73842260
97MET0.72022631
98PTK2B0.67874256
99ZAP700.67874086
100IRAK10.67817283
101TRIM280.66613654
102FLT30.66338829
103PRKG20.66102108
104MAPKAPK50.65903400
105CSNK1A10.65882657
106CDK80.65285463
107RPS6KA50.65144631
108MTOR0.64840123
109DAPK20.64704248
110CAMK2D0.62558035
111MAPKAPK30.61357072
112PAK30.61187408
113STK390.60713132
114DYRK1B0.60697841
115MUSK0.58765477
116TTK0.57532214
117PRKAA20.56965915
118PRKCA0.56432526
119ERBB20.56310639
120BRD40.56198627
121DAPK10.55966020
122EIF2AK30.55903361
123TNK20.55288900
124EPHA40.54643269
125RPS6KA40.53947857
126EGFR0.53005244
127TNIK0.52484000
128PRKCZ0.51742290
129ADRBK10.51290129
130KIT0.50976913
131STK40.50158302
132PKN20.50044032
133BMPR20.49597540
134PRKCI0.46022574
135GSK3A0.45033678
136FGFR30.44972184
137PRKCQ0.44084446
138PDGFRA0.43090866
139CSF1R0.41238074
140PRKCD0.40757594
141EPHA30.40293490
142ERBB30.39830965
143EIF2AK10.38934815
144VRK10.38840145
145MAPK150.38447907
146PRKACA0.38196272
147WEE10.37571976
148DYRK20.37549400
149IGF1R0.37000449
150JAK10.35604047
151CAMK2G0.35557080
152MAP3K80.35187335
153PLK10.34417023
154PBK0.34061134
155PAK20.33798427
156BTK0.33732626
157RPS6KA60.33070720
158MAP3K110.33016737
159CAMK2B0.32495040
160CAMK2A0.31986970
161MKNK10.30701637
162MAPKAPK20.29717664
163MAP2K10.28941460
164PRKACG0.27200963
165ITK0.26188327
166JAK20.24732739
167ABL10.24669944

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049783.06956185
2Renin-angiotensin system_Homo sapiens_hsa046142.63686353
3Sulfur metabolism_Homo sapiens_hsa009202.39839631
4Fat digestion and absorption_Homo sapiens_hsa049752.03002408
5Chemical carcinogenesis_Homo sapiens_hsa052041.97961588
6* Vitamin digestion and absorption_Homo sapiens_hsa049771.97903861
7Leukocyte transendothelial migration_Homo sapiens_hsa046701.97633770
8Steroid hormone biosynthesis_Homo sapiens_hsa001401.87189158
9Nitrogen metabolism_Homo sapiens_hsa009101.86807786
10Protein digestion and absorption_Homo sapiens_hsa049741.82778994
11Antigen processing and presentation_Homo sapiens_hsa046121.76541213
12Toxoplasmosis_Homo sapiens_hsa051451.76198765
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74924979
14Caffeine metabolism_Homo sapiens_hsa002321.74501330
15Arginine and proline metabolism_Homo sapiens_hsa003301.72527724
16Leishmaniasis_Homo sapiens_hsa051401.67362695
17Influenza A_Homo sapiens_hsa051641.65536145
18Retinol metabolism_Homo sapiens_hsa008301.64704363
19Propanoate metabolism_Homo sapiens_hsa006401.61571903
20Legionellosis_Homo sapiens_hsa051341.61398612
21Small cell lung cancer_Homo sapiens_hsa052221.58820786
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57356253
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.56210801
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.50057389
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48443248
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46962720
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45437898
28Proteasome_Homo sapiens_hsa030501.44492083
29Glutathione metabolism_Homo sapiens_hsa004801.43851780
30Ether lipid metabolism_Homo sapiens_hsa005651.43769208
31Peroxisome_Homo sapiens_hsa041461.43737714
32Dorso-ventral axis formation_Homo sapiens_hsa043201.41967638
33Folate biosynthesis_Homo sapiens_hsa007901.41743470
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41717598
35Starch and sucrose metabolism_Homo sapiens_hsa005001.41609533
36Fatty acid elongation_Homo sapiens_hsa000621.41186821
37Tryptophan metabolism_Homo sapiens_hsa003801.39826090
38Amoebiasis_Homo sapiens_hsa051461.38924259
39Arginine biosynthesis_Homo sapiens_hsa002201.37923104
40Tight junction_Homo sapiens_hsa045301.36234206
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36078826
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32554887
43Herpes simplex infection_Homo sapiens_hsa051681.31118736
44Salmonella infection_Homo sapiens_hsa051321.28032822
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27347709
46Butanoate metabolism_Homo sapiens_hsa006501.25346311
47Adherens junction_Homo sapiens_hsa045201.24696264
48Other glycan degradation_Homo sapiens_hsa005111.23398986
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.23204899
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22335199
51ECM-receptor interaction_Homo sapiens_hsa045121.18568379
52PPAR signaling pathway_Homo sapiens_hsa033201.17479135
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17411557
54Sulfur relay system_Homo sapiens_hsa041221.16140088
55Notch signaling pathway_Homo sapiens_hsa043301.14509020
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12770720
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10236459
58Histidine metabolism_Homo sapiens_hsa003401.07788407
59Fructose and mannose metabolism_Homo sapiens_hsa000511.06206917
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06167975
61Shigellosis_Homo sapiens_hsa051311.03899379
62Fatty acid biosynthesis_Homo sapiens_hsa000611.01778550
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01132569
64Arachidonic acid metabolism_Homo sapiens_hsa005901.00796406
65Oxidative phosphorylation_Homo sapiens_hsa001901.00242903
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00193957
67Selenocompound metabolism_Homo sapiens_hsa004501.00051122
68Sphingolipid metabolism_Homo sapiens_hsa006000.99268572
69Pertussis_Homo sapiens_hsa051330.99022459
70Viral myocarditis_Homo sapiens_hsa054160.98406846
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98355251
72Apoptosis_Homo sapiens_hsa042100.98099329
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97524441
74Glycerolipid metabolism_Homo sapiens_hsa005610.95539776
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95305032
76Bile secretion_Homo sapiens_hsa049760.94614742
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.93824862
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93724137
79Lysosome_Homo sapiens_hsa041420.93205814
80Focal adhesion_Homo sapiens_hsa045100.91891635
81Hepatitis C_Homo sapiens_hsa051600.91841826
82Measles_Homo sapiens_hsa051620.90432614
83TNF signaling pathway_Homo sapiens_hsa046680.89582795
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87178607
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.87119378
86Phototransduction_Homo sapiens_hsa047440.86218620
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.86116881
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83426471
89Pentose phosphate pathway_Homo sapiens_hsa000300.83287040
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81190470
91Fatty acid metabolism_Homo sapiens_hsa012120.79924562
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79904034
93Metabolic pathways_Homo sapiens_hsa011000.78549863
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.78095319
95TGF-beta signaling pathway_Homo sapiens_hsa043500.77846527
96Protein export_Homo sapiens_hsa030600.77690440
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76056421
98Fatty acid degradation_Homo sapiens_hsa000710.75877829
99Ovarian steroidogenesis_Homo sapiens_hsa049130.75716986
100Lysine degradation_Homo sapiens_hsa003100.74738778
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74108353
102ABC transporters_Homo sapiens_hsa020100.72035021
103Osteoclast differentiation_Homo sapiens_hsa043800.71532582
104Asthma_Homo sapiens_hsa053100.70660473
105Graft-versus-host disease_Homo sapiens_hsa053320.70135444
106Allograft rejection_Homo sapiens_hsa053300.67028377
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66873311
108Parkinsons disease_Homo sapiens_hsa050120.66368158
109VEGF signaling pathway_Homo sapiens_hsa043700.64468277
110Hematopoietic cell lineage_Homo sapiens_hsa046400.63019801
111Galactose metabolism_Homo sapiens_hsa000520.62733465
112p53 signaling pathway_Homo sapiens_hsa041150.62730654
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62611192
114Inositol phosphate metabolism_Homo sapiens_hsa005620.62420712
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62406370
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62179740
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.61827199
118Malaria_Homo sapiens_hsa051440.61354087
119Pyruvate metabolism_Homo sapiens_hsa006200.60936695
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59729716
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58547827
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57365308
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56520072
124Phenylalanine metabolism_Homo sapiens_hsa003600.56345002
125Taste transduction_Homo sapiens_hsa047420.55436795
126Proteoglycans in cancer_Homo sapiens_hsa052050.55227882
127Hippo signaling pathway_Homo sapiens_hsa043900.54905903
128Tuberculosis_Homo sapiens_hsa051520.54760019
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54682845
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54557959
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54127505
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.52875441
133B cell receptor signaling pathway_Homo sapiens_hsa046620.52592911
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52563777
135Thyroid cancer_Homo sapiens_hsa052160.52468625
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51695237
137beta-Alanine metabolism_Homo sapiens_hsa004100.51148548
138Pathways in cancer_Homo sapiens_hsa052000.50439445
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49639521
140Insulin resistance_Homo sapiens_hsa049310.49474699
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48989425
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48779032
143Linoleic acid metabolism_Homo sapiens_hsa005910.48732111
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48375304
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48079263
146Steroid biosynthesis_Homo sapiens_hsa001000.43655344
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.40590390
148Homologous recombination_Homo sapiens_hsa034400.37913192
149Pancreatic secretion_Homo sapiens_hsa049720.36007256
150Huntingtons disease_Homo sapiens_hsa050160.34887342
151N-Glycan biosynthesis_Homo sapiens_hsa005100.34022471
152Tyrosine metabolism_Homo sapiens_hsa003500.32887290
153Collecting duct acid secretion_Homo sapiens_hsa049660.30506810
154Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28782516
155Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28384104
156Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26704060
157Insulin secretion_Homo sapiens_hsa049110.25648366
158Alzheimers disease_Homo sapiens_hsa050100.25521408
159RNA degradation_Homo sapiens_hsa030180.24749658
160Basal transcription factors_Homo sapiens_hsa030220.23826149
161Regulation of autophagy_Homo sapiens_hsa041400.21617164
162Purine metabolism_Homo sapiens_hsa002300.21185602
163Base excision repair_Homo sapiens_hsa034100.17248780

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