SLC5A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)9.74942483
2drug transmembrane transport (GO:0006855)9.72370634
3lysine metabolic process (GO:0006553)9.28032790
4lysine catabolic process (GO:0006554)9.28032790
5aminoglycoside antibiotic metabolic process (GO:0030647)8.79765280
6organic cation transport (GO:0015695)8.78473433
7drug transport (GO:0015893)8.41478913
8phosphate ion transport (GO:0006817)7.51542762
9cysteine metabolic process (GO:0006534)7.05646555
10response to mercury ion (GO:0046689)6.59066275
11excretion (GO:0007588)6.55151118
12positive regulation of gamma-delta T cell activation (GO:0046645)6.51670135
13quaternary ammonium group transport (GO:0015697)6.41969915
14phosphate ion transmembrane transport (GO:0035435)6.37928376
15glyoxylate metabolic process (GO:0046487)6.22753659
16aspartate family amino acid catabolic process (GO:0009068)6.09141073
17renal absorption (GO:0070293)6.01329047
18nonribosomal peptide biosynthetic process (GO:0019184)5.90758928
19vitamin D metabolic process (GO:0042359)5.73455343
20metanephric tubule development (GO:0072170)5.68510284
21metanephric nephron tubule development (GO:0072234)5.68510284
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.62221765
23negative regulation of cell killing (GO:0031342)5.62221765
24tricarboxylic acid metabolic process (GO:0072350)5.61817182
25indole-containing compound catabolic process (GO:0042436)5.61094033
26indolalkylamine catabolic process (GO:0046218)5.61094033
27tryptophan catabolic process (GO:0006569)5.61094033
282-oxoglutarate metabolic process (GO:0006103)5.54680354
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.49287439
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.42617930
31glutathione biosynthetic process (GO:0006750)5.41547508
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.35461266
33short-chain fatty acid metabolic process (GO:0046459)5.28383895
34metanephric nephron epithelium development (GO:0072243)5.23046386
35tryptophan metabolic process (GO:0006568)5.21672874
36aromatic amino acid family catabolic process (GO:0009074)5.19821511
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.15929056
38antigen processing and presentation of endogenous antigen (GO:0019883)5.15634544
39valine metabolic process (GO:0006573)5.13994154
40branched-chain amino acid metabolic process (GO:0009081)5.08988717
41drug catabolic process (GO:0042737)5.05104080
42modified amino acid transport (GO:0072337)5.02337361
43toxin transport (GO:1901998)5.01635414
44regulation of B cell receptor signaling pathway (GO:0050855)4.93057623
45kynurenine metabolic process (GO:0070189)4.91742697
46regulation of gamma-delta T cell differentiation (GO:0045586)4.86760797
47response to phenylpropanoid (GO:0080184)4.86012647
48carnitine transport (GO:0015879)4.83355694
49amino-acid betaine transport (GO:0015838)4.83355694
50regulation of gamma-delta T cell activation (GO:0046643)4.80580850
51homocysteine metabolic process (GO:0050667)4.80152146
52metanephric epithelium development (GO:0072207)4.78148136
53cellular modified amino acid catabolic process (GO:0042219)4.75696899
54positive regulation of granulocyte differentiation (GO:0030854)4.69600983
55polyol transport (GO:0015791)4.64908851
56exogenous drug catabolic process (GO:0042738)4.63905982
57L-phenylalanine metabolic process (GO:0006558)4.62491473
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.62491473
59negative T cell selection (GO:0043383)4.61674830
60phosphate ion homeostasis (GO:0055062)4.58504300
61trivalent inorganic anion homeostasis (GO:0072506)4.58504300
62glutamate metabolic process (GO:0006536)4.56606194
63amino-acid betaine metabolic process (GO:0006577)4.53183871
64serine family amino acid catabolic process (GO:0009071)4.50378436
65negative thymic T cell selection (GO:0045060)4.49043648
66fructose metabolic process (GO:0006000)4.48024330
67acetyl-CoA metabolic process (GO:0006084)4.47308930
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.45986710
69L-phenylalanine catabolic process (GO:0006559)4.45986710
70proline metabolic process (GO:0006560)4.40591846
71nephron tubule development (GO:0072080)4.39016265
72serine family amino acid metabolic process (GO:0009069)4.37956725
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.37509245
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.36338374
75tolerance induction (GO:0002507)4.35655192
76B cell receptor signaling pathway (GO:0050853)4.32368177
77peptide biosynthetic process (GO:0043043)4.32055902
78fatty acid beta-oxidation (GO:0006635)4.31229827
79carnitine metabolic process (GO:0009437)4.27702425
80peptide catabolic process (GO:0043171)4.24405876
81negative regulation of T-helper cell differentiation (GO:0045623)4.23296237
82negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.23296237
83positive T cell selection (GO:0043368)4.21897579
84positive thymic T cell selection (GO:0045059)4.21284376
85cellular ketone body metabolic process (GO:0046950)4.15203925
86fatty acid oxidation (GO:0019395)4.14205529
87positive regulation of isotype switching (GO:0045830)4.12282935
88branched-chain amino acid catabolic process (GO:0009083)4.08996704
89vitamin transport (GO:0051180)4.07878335
90leukocyte aggregation (GO:0070486)4.07049177
91lipid oxidation (GO:0034440)4.06222481
92negative regulation of T cell mediated immunity (GO:0002710)4.05626344
93response to interleukin-15 (GO:0070672)4.04451820
94glycoside metabolic process (GO:0016137)4.01741477
95regulation of regulatory T cell differentiation (GO:0045589)3.96259169
96indolalkylamine metabolic process (GO:0006586)3.92088573
97CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.91091424
98cellular response to interleukin-15 (GO:0071350)3.90321158
99renal tubule development (GO:0061326)3.89501962
100T cell selection (GO:0045058)3.86116789
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.84851580
102aromatic amino acid family metabolic process (GO:0009072)3.84251631
103oligosaccharide catabolic process (GO:0009313)3.82872349
104indole-containing compound metabolic process (GO:0042430)3.81269187
105regulation of alpha-beta T cell proliferation (GO:0046640)3.80268629
106modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.76401819
107positive regulation by organism of defense response of other organism involved in symbiotic interact3.76401819
108modulation by symbiont of host immune response (GO:0052553)3.76401819
109positive regulation by symbiont of host defense response (GO:0052509)3.76401819
110modulation by symbiont of host defense response (GO:0052031)3.76401819
111modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.76401819
112NADH metabolic process (GO:0006734)3.74969501
113surfactant homeostasis (GO:0043129)3.73371028
114regulation of isotype switching to IgG isotypes (GO:0048302)3.73063040
115positive regulation of DNA recombination (GO:0045911)3.72867279
116cellular amino acid catabolic process (GO:0009063)3.71268763
117negative regulation of lymphocyte mediated immunity (GO:0002707)3.71133358
118antigen processing and presentation via MHC class Ib (GO:0002475)3.70841732
119glutathione derivative metabolic process (GO:1901685)3.64621479
120glutathione derivative biosynthetic process (GO:1901687)3.64621479
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.63442945
122nephron epithelium development (GO:0072009)3.62079985
123alpha-amino acid catabolic process (GO:1901606)3.61030906
124thymic T cell selection (GO:0045061)3.60874697
125response to growth hormone (GO:0060416)3.59459238
126benzene-containing compound metabolic process (GO:0042537)3.59199186
127amine catabolic process (GO:0009310)3.57548005
128cellular biogenic amine catabolic process (GO:0042402)3.57548005
129transepithelial transport (GO:0070633)3.57388763
130ketone body metabolic process (GO:1902224)3.56919584
131fatty acid catabolic process (GO:0009062)3.53825200
132serine family amino acid biosynthetic process (GO:0009070)3.53421146
133cellular extravasation (GO:0045123)3.50690750
134biotin metabolic process (GO:0006768)3.50425468
135sulfur amino acid catabolic process (GO:0000098)3.50081153
136regulation of T cell mediated cytotoxicity (GO:0001914)3.49157556
137detection of bacterium (GO:0016045)3.49108099
138regulation of B cell differentiation (GO:0045577)3.48116986
139negative regulation of alpha-beta T cell activation (GO:0046636)3.47076267
140glutathione metabolic process (GO:0006749)3.46378877
141neutrophil activation involved in immune response (GO:0002283)3.45979305
142T cell homeostasis (GO:0043029)3.45202794
143positive regulation of B cell differentiation (GO:0045579)3.44340849
144L-ascorbic acid metabolic process (GO:0019852)3.43564262
145regulation of granulocyte differentiation (GO:0030852)3.39770735
146mast cell activation (GO:0045576)3.39215887
147regulation of natural killer cell mediated immunity (GO:0002715)3.38532414
148regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.38532414
149T cell migration (GO:0072678)3.37429189
150defense response to protozoan (GO:0042832)3.37242692
151carboxylic acid catabolic process (GO:0046395)3.37146320
152organic acid catabolic process (GO:0016054)3.37146320
153activated T cell proliferation (GO:0050798)3.37005488
154sulfur compound transport (GO:0072348)3.36719814
155dicarboxylic acid metabolic process (GO:0043648)3.35786353
156regulation of isotype switching (GO:0045191)3.35552765
157interferon-gamma production (GO:0032609)3.35530675
158positive regulation of T cell mediated cytotoxicity (GO:0001916)3.34151349
159sodium-independent organic anion transport (GO:0043252)3.33478088
160detection of other organism (GO:0098543)3.32830672
161leukocyte degranulation (GO:0043299)3.32226438
162oxaloacetate metabolic process (GO:0006107)3.30093163
163positive regulation of immunoglobulin mediated immune response (GO:0002891)3.29954083
164positive regulation of B cell mediated immunity (GO:0002714)3.29954083
165monocarboxylic acid catabolic process (GO:0072329)3.29352103
166regulation of MHC class II biosynthetic process (GO:0045346)3.28957324
167positive regulation of immunoglobulin production (GO:0002639)3.28789487
168regulation of interferon-beta biosynthetic process (GO:0045357)3.24759962
169negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.24346680
170antigen receptor-mediated signaling pathway (GO:0050851)3.18590502
171positive regulation of alpha-beta T cell proliferation (GO:0046641)3.17162500
172negative regulation of phagocytosis (GO:0050765)3.14022904
173response to protozoan (GO:0001562)3.13960276
174regulation of T cell tolerance induction (GO:0002664)3.11733932
175natural killer cell differentiation (GO:0001779)3.10119939
176negative regulation of leukocyte mediated immunity (GO:0002704)3.09976533
177regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.07624060
178cellular response to exogenous dsRNA (GO:0071360)3.07259705
179mast cell degranulation (GO:0043303)3.07082718
180mast cell activation involved in immune response (GO:0002279)3.07082718
181lymphocyte homeostasis (GO:0002260)3.05356148
182Peyers patch development (GO:0048541)3.03757866
183mucosal-associated lymphoid tissue development (GO:0048537)3.03757866
184NIK/NF-kappaB signaling (GO:0038061)3.03266577
185regulation of leukocyte mediated cytotoxicity (GO:0001910)3.02931016
186regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.00437491
187regulation of alpha-beta T cell activation (GO:0046634)2.99345582
188negative regulation of adaptive immune response (GO:0002820)2.98582198
189myeloid cell activation involved in immune response (GO:0002275)2.96656010
190regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95021456
191germinal center formation (GO:0002467)2.94492138
192alpha-beta T cell differentiation (GO:0046632)2.93129105
193positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.92901162
194B cell homeostasis (GO:0001782)2.92863977
195regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.91620874
196regulation of B cell mediated immunity (GO:0002712)2.91576949
197positive regulation of B cell activation (GO:0050871)2.91314039
198positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89824718
199positive regulation of natural killer cell differentiation (GO:0032825)2.89526536
200macrophage activation involved in immune response (GO:0002281)2.88192865

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.80581192
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.76414455
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.24215654
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.85045534
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.80325988
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.35712016
7PPARA_22158963_ChIP-Seq_LIVER_Mouse4.03836793
8ESR1_21235772_ChIP-Seq_MCF-7_Human3.71083053
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.70130281
10RUNX_20019798_ChIP-Seq_JUKART_Human3.56538234
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.44281189
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03737227
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.99959330
14MYB_26560356_Chip-Seq_TH2_Human2.96164066
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.83005601
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.76146098
17VDR_22108803_ChIP-Seq_LS180_Human2.75425067
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.70157973
19MYC_22102868_ChIP-Seq_BL_Human2.67356246
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.66761292
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.66135810
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63226684
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.60258261
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57227934
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.52148439
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48123703
27TRIM28_21343339_ChIP-Seq_HEK293_Human2.46392831
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.43573339
29* MYB_26560356_Chip-Seq_TH1_Human2.43420506
30MAF_26560356_Chip-Seq_TH1_Human2.40649987
31SCL_19346495_ChIP-Seq_HPC-7_Human2.36299776
32UTX_26944678_Chip-Seq_JUKART_Human2.36021768
33AR_21909140_ChIP-Seq_LNCAP_Human2.35985468
34VDR_21846776_ChIP-Seq_THP-1_Human2.34312873
35RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30678613
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.25334318
37VDR_24763502_ChIP-Seq_THP-1_Human2.24284896
38IRF8_27001747_Chip-Seq_BMDM_Mouse2.22768350
39NOTCH1_21737748_ChIP-Seq_TLL_Human2.19728571
40CLOCK_20551151_ChIP-Seq_293T_Human2.18305119
41* SPI1_23547873_ChIP-Seq_NB4_Human2.12631968
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12009365
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.11688478
44GATA3_27048872_Chip-Seq_THYMUS_Human2.10907500
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09415331
46STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08260991
47CDX2_20551321_ChIP-Seq_CACO-2_Human2.04690988
48GATA3_26560356_Chip-Seq_TH2_Human2.03460238
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98894511
50MAF_26560356_Chip-Seq_TH2_Human1.95545733
51SPI1_23127762_ChIP-Seq_K562_Human1.86736555
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83345371
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.81942939
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78795053
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72526415
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71535556
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70814752
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70386326
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.67360303
60CIITA_25753668_ChIP-Seq_RAJI_Human1.66812938
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66483582
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66086655
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63053026
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61341164
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61302155
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59522615
67GATA4_25053715_ChIP-Seq_YYC3_Human1.58314674
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54818881
69TCF7_22412390_ChIP-Seq_EML_Mouse1.54312300
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54153678
71LXR_22292898_ChIP-Seq_THP-1_Human1.51379663
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51036341
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48978290
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48419863
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46328117
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.45388220
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44988545
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43900717
79EGR1_19032775_ChIP-ChIP_M12_Human1.43135282
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40640268
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40017389
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39996334
83* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38050933
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36207913
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35488026
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33941356
87RACK7_27058665_Chip-Seq_MCF-7_Human1.31027492
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28585878
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27036575
90* FOXA2_19822575_ChIP-Seq_HepG2_Human1.26415900
91KDM2B_26808549_Chip-Seq_DND41_Human1.23611556
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23589746
93GATA1_19941826_ChIP-Seq_K562_Human1.22777741
94GATA6_25053715_ChIP-Seq_YYC3_Human1.22543918
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22467066
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21855624
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.21843980
98BCL6_27268052_Chip-Seq_Bcells_Human1.19999643
99GATA1_22025678_ChIP-Seq_K562_Human1.19831024
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19657490
101RXR_22108803_ChIP-Seq_LS180_Human1.19213336
102SOX2_20726797_ChIP-Seq_SW620_Human1.17915930
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16425699
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16268995
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.15215541
106* BCOR_27268052_Chip-Seq_Bcells_Human1.14980336
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14643396
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12604369
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12358942
110TBX20_22080862_ChIP-Seq_HEART_Mouse1.11619455
111TBX20_22328084_ChIP-Seq_HEART_Mouse1.11619455
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11511403
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11100710
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10760457
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09856737
116IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08699851
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08619707
118GATA1_19941827_ChIP-Seq_MEL_Mouse1.08456883
119PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08314037
120P300_27268052_Chip-Seq_Bcells_Human1.08224059
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07545610
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07427542
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04654967
124EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04360225
125VDR_23849224_ChIP-Seq_CD4+_Human1.03407663
126PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03342861
127ERG_21242973_ChIP-ChIP_JURKAT_Human1.03209372
128FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02277936
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01714413
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01604567
131SMRT_27268052_Chip-Seq_Bcells_Human1.01055083
132CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00782490
133SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00022401
134PU_27001747_Chip-Seq_BMDM_Mouse0.99898162
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99239996
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98570650
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98012851
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97765079
139PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97757676
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97541619
141BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97489329
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94418489
143GATA2_21666600_ChIP-Seq_HMVEC_Human0.94031604
144RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93884122
145FOXP3_21729870_ChIP-Seq_TREG_Human0.91197375
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89989390
147GATA3_26560356_Chip-Seq_TH1_Human0.89317478
148SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89263259
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89038513
150NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88599744
151TP63_23658742_ChIP-Seq_EP156T_Human0.87917370
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86915496
153ELF1_20517297_ChIP-Seq_JURKAT_Human0.86885753
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.86077278
155NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86066334
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85331329
157CDX2_22108803_ChIP-Seq_LS180_Human0.84918260
158VDR_24787735_ChIP-Seq_THP-1_Human0.84288453
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84219764
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84214341
161EP300_21415370_ChIP-Seq_HL-1_Mouse0.83873917
162RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83355974
163* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83317488
164KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82835491
165SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82578112
166CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80761442
167* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80383274
168GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80186780
169NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79303987
170* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79258490
171HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79146930
172* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79101274
173WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79009012
174NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78833669
175RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78270317
176EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77879100
177FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77008093
178GATA2_19941826_ChIP-Seq_K562_Human0.76183410
179MTF2_20144788_ChIP-Seq_MESCs_Mouse0.76162982
180* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75601499
181CJUN_26792858_Chip-Seq_BT549_Human0.75213232
182NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75029064
183NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75029064
184RAC3_21632823_ChIP-Seq_H3396_Human0.74718012
185CREB1_26743006_Chip-Seq_LNCaP_Human0.74273943
186AHR_22903824_ChIP-Seq_MCF-7_Human0.74081434
187CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73912532
188SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72922903
189ARNT_22903824_ChIP-Seq_MCF-7_Human0.70941143
190RUNX1_27514584_Chip-Seq_MCF-7_Human0.69105441
191* SMC4_20622854_ChIP-Seq_HELA_Human0.68275956
192SOX11_22085726_ChIP-Seq_ESNs_Mouse0.67500146
193ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67428122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.08351855
2MP0004043_abnormal_pH_regulation6.29751551
3MP0005332_abnormal_amino_acid4.92954551
4MP0004019_abnormal_vitamin_homeostasis4.92950533
5MP0003195_calcinosis4.84783644
6MP0002139_abnormal_hepatobiliary_system4.23019762
7MP0009643_abnormal_urine_homeostasis4.02452333
8MP0001765_abnormal_ion_homeostasis3.78744473
9MP0002138_abnormal_hepatobiliary_system3.76603769
10MP0005671_abnormal_response_to3.74329219
11MP0003763_abnormal_thymus_physiology3.71366058
12MP0001835_abnormal_antigen_presentation3.67435408
13MP0003436_decreased_susceptibility_to3.49709145
14MP0001756_abnormal_urination3.39093313
15MP0001800_abnormal_humoral_immune3.23976054
16MP0000685_abnormal_immune_system3.09729468
17MP0005636_abnormal_mineral_homeostasis3.09007215
18MP0003878_abnormal_ear_physiology3.03441670
19MP0005377_hearing/vestibular/ear_phenot3.03441670
20MP0002136_abnormal_kidney_physiology3.01836257
21MP0001790_abnormal_immune_system3.00097228
22MP0005387_immune_system_phenotype3.00097228
23MP0005075_abnormal_melanosome_morpholog2.93911305
24MP0005000_abnormal_immune_tolerance2.85648761
25MP0004381_abnormal_hair_follicle2.79907220
26MP0008875_abnormal_xenobiotic_pharmacok2.75171649
27MP0000372_irregular_coat_pigmentation2.65721914
28MP0002723_abnormal_immune_serum2.59738194
29MP0002420_abnormal_adaptive_immunity2.57631489
30MP0001819_abnormal_immune_cell2.53198842
31MP0001873_stomach_inflammation2.51083155
32MP0001958_emphysema2.49720866
33MP0002452_abnormal_antigen_presenting2.45807430
34MP0005365_abnormal_bile_salt2.43673037
35MP0005025_abnormal_response_to2.35132512
36MP0003252_abnormal_bile_duct2.34327355
37MP0000015_abnormal_ear_pigmentation2.28475336
38MP0002419_abnormal_innate_immunity2.28471151
39MP0002398_abnormal_bone_marrow2.13130892
40MP0003303_peritoneal_inflammation2.08332896
41MP0009785_altered_susceptibility_to2.05388474
42MP0000716_abnormal_immune_system2.03838728
43MP0002148_abnormal_hypersensitivity_rea2.03045444
44MP0005085_abnormal_gallbladder_physiolo2.02427199
45MP0000703_abnormal_thymus_morphology1.97440947
46MP0005058_abnormal_lysosome_morphology1.96244707
47MP0008961_abnormal_basal_metabolism1.94607440
48MP0002396_abnormal_hematopoietic_system1.92160086
49MP0000538_abnormal_urinary_bladder1.91326093
50MP0005310_abnormal_salivary_gland1.89666714
51MP0002405_respiratory_system_inflammati1.87251790
52MP0000689_abnormal_spleen_morphology1.85512633
53MP0009333_abnormal_splenocyte_physiolog1.76135996
54MP0002722_abnormal_immune_system1.75930509
55MP0006082_CNS_inflammation1.75799598
56MP0010155_abnormal_intestine_physiology1.70262206
57MP0002429_abnormal_blood_cell1.63433579
58MP0003866_abnormal_defecation1.57473915
59MP0002876_abnormal_thyroid_physiology1.57195323
60MP0004885_abnormal_endolymph1.54840863
61MP0005464_abnormal_platelet_physiology1.54170392
62MP0005584_abnormal_enzyme/coenzyme_acti1.52335502
63MP0003300_gastrointestinal_ulcer1.52123117
64MP0002166_altered_tumor_susceptibility1.51418246
65MP0005451_abnormal_body_composition1.50247541
66MP0001348_abnormal_lacrimal_gland1.50127473
67MP0004947_skin_inflammation1.48633707
68MP0001533_abnormal_skeleton_physiology1.47263390
69MP0005174_abnormal_tail_pigmentation1.46535658
70MP0003191_abnormal_cellular_cholesterol1.43987835
71MP0003186_abnormal_redox_activity1.41951587
72MP0000465_gastrointestinal_hemorrhage1.35220261
73MP0003283_abnormal_digestive_organ1.34794271
74MP0002095_abnormal_skin_pigmentation1.34557968
75MP0002009_preneoplasia1.33623355
76MP0002168_other_aberrant_phenotype1.29958948
77MP0000230_abnormal_systemic_arterial1.29460542
78MP0001986_abnormal_taste_sensitivity1.28641049
79MP0001851_eye_inflammation1.28298772
80MP0005319_abnormal_enzyme/_coenzyme1.24518333
81MP0002132_abnormal_respiratory_system1.20296324
82MP0005670_abnormal_white_adipose1.16918291
83MP0002928_abnormal_bile_duct1.15073387
84MP0002135_abnormal_kidney_morphology1.14242617
85MP0003136_yellow_coat_color1.13573237
86MP0001666_abnormal_nutrient_absorption1.12964742
87MP0005084_abnormal_gallbladder_morpholo1.08160114
88MP0002896_abnormal_bone_mineralization1.07048906
89MP0002933_joint_inflammation1.05524876
90MP0005535_abnormal_body_temperature1.04281663
91MP0001663_abnormal_digestive_system1.03568458
92MP0006036_abnormal_mitochondrial_physio1.01629726
93MP0002796_impaired_skin_barrier1.01580788
94MP0003806_abnormal_nucleotide_metabolis0.98618394
95MP0004264_abnormal_extraembryonic_tissu0.97319575
96MP0002089_abnormal_postnatal_growth/wei0.95799416
97MP0001764_abnormal_homeostasis0.94782947
98MP0010234_abnormal_vibrissa_follicle0.94701749
99MP0003638_abnormal_response/metabolism_0.93232375
100MP0002006_tumorigenesis0.92736765
101MP0003183_abnormal_peptide_metabolism0.91962693
102MP0005666_abnormal_adipose_tissue0.91497928
103MP0008872_abnormal_physiological_respon0.86263894
104MP0002118_abnormal_lipid_homeostasis0.84398662
105MP0001661_extended_life_span0.81301379
106MP0009278_abnormal_bone_marrow0.77442600
107MP0000569_abnormal_digit_pigmentation0.77093780
108MP0003959_abnormal_lean_body0.76935500
109MP0005171_absent_coat_pigmentation0.75907581
110MP0002277_abnormal_respiratory_mucosa0.75804039
111MP0004808_abnormal_hematopoietic_stem0.75746627
112MP0002693_abnormal_pancreas_physiology0.73634713
113MP0005395_other_phenotype0.72754932
114MP0009642_abnormal_blood_homeostasis0.72591415
115MP0002019_abnormal_tumor_incidence0.71637209
116MP0003646_muscle_fatigue0.70849325
117MP0002653_abnormal_ependyma_morphology0.68742443
118MP0000490_abnormal_crypts_of0.68046601
119MP0009764_decreased_sensitivity_to0.67060421
120MP0010329_abnormal_lipoprotein_level0.62766691
121MP0005220_abnormal_exocrine_pancreas0.61966517
122MP0004147_increased_porphyrin_level0.60470410
123MP0003172_abnormal_lysosome_physiology0.59780425
124MP0005501_abnormal_skin_physiology0.58403773
125MP0003045_fibrosis0.58001103
126MP0002075_abnormal_coat/hair_pigmentati0.57676590
127MP0001324_abnormal_eye_pigmentation0.57346107
128MP0008057_abnormal_DNA_replication0.56571152
129MP0000609_abnormal_liver_physiology0.56289918
130MP0000249_abnormal_blood_vessel0.56251254
131MP0005381_digestive/alimentary_phenotyp0.54218934
132MP0002098_abnormal_vibrissa_morphology0.54206719
133MP0003795_abnormal_bone_structure0.54195596
134MP0004858_abnormal_nervous_system0.51404299
135MP0008469_abnormal_protein_level0.50270229
136MP0003879_abnormal_hair_cell0.50160954
137MP0009763_increased_sensitivity_to0.49857352
138MP0009840_abnormal_foam_cell0.49606296
139MP0000534_abnormal_ureter_morphology0.49412412
140MP0002998_abnormal_bone_remodeling0.48682157
141MP0003828_pulmonary_edema0.48506694
142MP0003315_abnormal_perineum_morphology0.48361931
143MP0000747_muscle_weakness0.47860636
144MP0004272_abnormal_basement_membrane0.47493523
145MP0005397_hematopoietic_system_phenotyp0.47454955
146MP0001545_abnormal_hematopoietic_system0.47454955
147MP0003329_amyloid_beta_deposits0.47288792
148MP0002115_abnormal_skeleton_extremities0.47160841
149MP0002078_abnormal_glucose_homeostasis0.46791615
150MP0005166_decreased_susceptibility_to0.46733468
151MP0000371_diluted_coat_color0.44918227
152MP0003953_abnormal_hormone_level0.43288207
153MP0005165_increased_susceptibility_to0.42824699
154MP0002069_abnormal_eating/drinking_beha0.42391851
155MP0000598_abnormal_liver_morphology0.42053090
156MP0005167_abnormal_blood-brain_barrier0.40396259
157MP0004742_abnormal_vestibular_system0.38988763
158MP0005375_adipose_tissue_phenotype0.38079552
159MP0003724_increased_susceptibility_to0.37436513
160MP0001485_abnormal_pinna_reflex0.35477648
161MP0000163_abnormal_cartilage_morphology0.35395308
162MP0006035_abnormal_mitochondrial_morpho0.35089003
163MP0010386_abnormal_urinary_bladder0.34514841
164MP0001177_atelectasis0.32073518
165MP0000678_abnormal_parathyroid_gland0.30809396
166MP0001270_distended_abdomen0.30022193
167MP0003075_altered_response_to0.29196772
168MP0001664_abnormal_digestion0.29064785
169MP0001963_abnormal_hearing_physiology0.27963972
170MP0000367_abnormal_coat/_hair0.27756476
171MP0009780_abnormal_chondrocyte_physiolo0.27706869
172MP0005408_hypopigmentation0.27669369
173MP0001845_abnormal_inflammatory_respons0.26436705
174MP0001731_abnormal_postnatal_growth0.25854078
175MP0004484_altered_response_of0.25834438

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)8.00827118
2Metabolic alkalosis (HP:0200114)7.82925428
3Hypokalemic alkalosis (HP:0001949)7.58055244
4Hypomagnesemia (HP:0002917)7.47027313
5Hyperactive renin-angiotensin system (HP:0000841)7.15602919
6Polyuria (HP:0000103)6.90793342
7Gout (HP:0001997)6.72766151
8Abnormal urine output (HP:0012590)6.55779367
9Abnormality of chloride homeostasis (HP:0011422)6.41499174
10Abnormality of magnesium homeostasis (HP:0004921)6.31810623
11Abnormality of renal excretion (HP:0011036)6.09357602
12Abnormal drinking behavior (HP:0030082)5.65424945
13Polydipsia (HP:0001959)5.65424945
14Panhypogammaglobulinemia (HP:0003139)5.43956976
15Tetany (HP:0001281)5.31680717
16Increased purine levels (HP:0004368)5.22781383
17Hyperuricemia (HP:0002149)5.22781383
18Proximal tubulopathy (HP:0000114)5.19397630
19Abnormal delayed hypersensitivity skin test (HP:0002963)5.16076632
20Renal salt wasting (HP:0000127)5.07716561
21Hyperaldosteronism (HP:0000859)4.97778454
22Abnormality of renin-angiotensin system (HP:0000847)4.97712066
23Hyperglycinuria (HP:0003108)4.82371589
24Alkalosis (HP:0001948)4.81481006
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.73603921
26Stomatitis (HP:0010280)4.59046836
27T lymphocytopenia (HP:0005403)4.42570131
28Eczematoid dermatitis (HP:0000976)4.36090200
29Recurrent fungal infections (HP:0002841)4.35829370
30Abnormality of purine metabolism (HP:0004352)4.33170533
31Elevated erythrocyte sedimentation rate (HP:0003565)4.18528869
32Abnormality of T cell number (HP:0011839)4.09101998
33Recurrent cutaneous fungal infections (HP:0011370)4.09013134
34Chronic mucocutaneous candidiasis (HP:0002728)4.09013134
35Abnormality of T cells (HP:0002843)4.04440561
36Hypercalciuria (HP:0002150)3.99479688
37Abnormality of serine family amino acid metabolism (HP:0010894)3.88427663
38Abnormality of glycine metabolism (HP:0010895)3.88427663
39Hypokalemia (HP:0002900)3.83829738
40Ketoacidosis (HP:0001993)3.82381417
41Myositis (HP:0100614)3.82023180
42Recurrent bacterial skin infections (HP:0005406)3.80439498
43Pustule (HP:0200039)3.79338345
44Renal tubular acidosis (HP:0001947)3.72319948
45Recurrent abscess formation (HP:0002722)3.68130064
46Meningitis (HP:0001287)3.65794255
47Abnormality of T cell physiology (HP:0011840)3.62401043
48IgG deficiency (HP:0004315)3.59401471
49Generalized aminoaciduria (HP:0002909)3.56074583
50Abnormality of B cell number (HP:0010975)3.50009682
51Severe combined immunodeficiency (HP:0004430)3.46464594
52Recurrent viral infections (HP:0004429)3.46006025
53Agammaglobulinemia (HP:0004432)3.44104865
54Encephalitis (HP:0002383)3.44075708
55Recurrent skin infections (HP:0001581)3.35980652
56B lymphocytopenia (HP:0010976)3.26493120
57Ketosis (HP:0001946)3.22454428
58Abnormality of urine glucose concentration (HP:0011016)3.21608871
59Glycosuria (HP:0003076)3.21608871
60Inflammation of the large intestine (HP:0002037)3.20477127
61Ocular albinism (HP:0001107)3.17069167
62Abnormality of potassium homeostasis (HP:0011042)3.14176806
63Gastrointestinal inflammation (HP:0004386)3.11859460
64Optic neuritis (HP:0100653)3.09105056
65Retrobulbar optic neuritis (HP:0100654)3.09105056
66Abnormality of nucleobase metabolism (HP:0010932)3.08464756
67Mediastinal lymphadenopathy (HP:0100721)3.01370450
68Abnormality of fatty-acid metabolism (HP:0004359)2.99143292
69Nephrocalcinosis (HP:0000121)2.97971366
70Abnormality of proline metabolism (HP:0010907)2.97934400
71Hydroxyprolinuria (HP:0003080)2.97934400
72Hypoplasia of the thymus (HP:0000778)2.96508260
73IgM deficiency (HP:0002850)2.96442728
74Increased IgE level (HP:0003212)2.95827363
75Orchitis (HP:0100796)2.91420650
76Hypochromic anemia (HP:0001931)2.91227648
77Hyperphosphaturia (HP:0003109)2.91214724
78Vasculitis (HP:0002633)2.90359195
79Congenital stationary night blindness (HP:0007642)2.89293355
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.86964783
81Hypochromic microcytic anemia (HP:0004840)2.83937185
82Abnormality of macrophages (HP:0004311)2.82684037
83Delayed CNS myelination (HP:0002188)2.81001603
84Prolonged bleeding time (HP:0003010)2.80062671
85Delayed epiphyseal ossification (HP:0002663)2.80054732
86Lymphopenia (HP:0001888)2.77061946
87Recurrent bronchitis (HP:0002837)2.76765130
88Granulocytopenia (HP:0001913)2.74247348
89Colitis (HP:0002583)2.73450112
90Abnormal urine phosphate concentration (HP:0012599)2.72355057
91Combined immunodeficiency (HP:0005387)2.68612594
92Gastrointestinal infarctions (HP:0005244)2.67484275
93Spontaneous hematomas (HP:0007420)2.66873707
94Abnormality of eosinophils (HP:0001879)2.66372247
95Nephrolithiasis (HP:0000787)2.65758443
96Leukocytosis (HP:0001974)2.63664476
97Iris hypopigmentation (HP:0007730)2.63555492
98Viral hepatitis (HP:0006562)2.62289921
99Eosinophilia (HP:0001880)2.62219412
100Autoimmune hemolytic anemia (HP:0001890)2.60553278
101Dehydration (HP:0001944)2.59472566
102Abnormality of sodium homeostasis (HP:0010931)2.58923035
103Obstructive lung disease (HP:0006536)2.58119176
104Chronic obstructive pulmonary disease (HP:0006510)2.58119176
105Thyroiditis (HP:0100646)2.56839308
106IgA deficiency (HP:0002720)2.55186471
107Recurrent gram-negative bacterial infections (HP:0005420)2.54385528
108Gastrointestinal stroma tumor (HP:0100723)2.52370799
109Stomach cancer (HP:0012126)2.48474765
110Abnormality of cells of the lymphoid lineage (HP:0012140)2.47799316
111Hyperglycinemia (HP:0002154)2.46649552
112Hypophosphatemia (HP:0002148)2.45393493
113Pulmonary infiltrates (HP:0002113)2.44558917
114Recurrent sinusitis (HP:0011108)2.41185955
115Papilloma (HP:0012740)2.40150577
116Verrucae (HP:0200043)2.40150577
117Hyponatremia (HP:0002902)2.39960324
118Vacuolated lymphocytes (HP:0001922)2.39635880
119Widely patent fontanelles and sutures (HP:0004492)2.36735136
120Keratoconjunctivitis (HP:0001096)2.36093893
121Chest pain (HP:0100749)2.34728523
122Metaphyseal cupping (HP:0003021)2.32142750
123Rickets (HP:0002748)2.31227810
124Adrenal overactivity (HP:0002717)2.29871730
125Keratoconjunctivitis sicca (HP:0001097)2.28630041
126Vascular calcification (HP:0004934)2.28453763
127Albinism (HP:0001022)2.26486361
128Confusion (HP:0001289)2.25931636
129Abnormality of sulfur amino acid metabolism (HP:0004339)2.25684019
130Potter facies (HP:0002009)2.25374743
131Facial shape deformation (HP:0011334)2.25374743
132Dicarboxylic aciduria (HP:0003215)2.24381824
133Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24381824
134Vomiting (HP:0002013)2.23433414
135Metabolic acidosis (HP:0001942)2.22933844
136Enlarged kidneys (HP:0000105)2.22223782
137Microcytic anemia (HP:0001935)2.21948822
138Hyperammonemia (HP:0001987)2.21668564
139Hemoptysis (HP:0002105)2.18841532
140Renal tubular dysfunction (HP:0000124)2.18767439
141Anorexia (HP:0002039)2.14229947
142Malnutrition (HP:0004395)2.12438852
143Abnormality of the fingertips (HP:0001211)2.10630530
144Cellulitis (HP:0100658)2.10519490
145Tubular atrophy (HP:0000092)2.06904213
146Basal cell carcinoma (HP:0002671)2.06819269
147Chronic otitis media (HP:0000389)2.06292348
148Epistaxis (HP:0000421)2.05219628
149Lymphoma (HP:0002665)2.03785167
150Gingivitis (HP:0000230)2.03385717
151Cardiovascular calcification (HP:0011915)2.02726573
152Urticaria (HP:0001025)2.02673402
153Chronic diarrhea (HP:0002028)2.01994383
154Chondrocalcinosis (HP:0000934)2.01070162
155Autoimmune thrombocytopenia (HP:0001973)1.99154950
156Recurrent lower respiratory tract infections (HP:0002783)1.98410877
157Bilateral sensorineural hearing impairment (HP:0008619)1.98232474
158Abnormality of renal resorption (HP:0011038)1.98012352
159Tubulointerstitial fibrosis (HP:0005576)1.97424795
160Increased IgM level (HP:0003496)1.97244387
161Decreased circulating renin level (HP:0003351)1.97200147
162Abnormality of the prostate (HP:0008775)1.94684715
163Recurrent pneumonia (HP:0006532)1.94009676
164Aplasia/Hypoplasia of the macula (HP:0008059)1.92802480
165Abnormal tarsal ossification (HP:0008369)1.92611448
166Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92208938
167Aplasia/Hypoplasia of the thymus (HP:0010515)1.91366119
168Sepsis (HP:0100806)1.89216200
169Abnormality of Sharpey fibers (HP:0100685)1.88876036
170Abnormal enzyme/coenzyme activity (HP:0012379)1.86462360
171Lethargy (HP:0001254)1.86345388
172Osteomyelitis (HP:0002754)1.85323079
173Methylmalonic aciduria (HP:0012120)1.83779159
174Hypotension (HP:0002615)1.83635007
175Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81666412
176Abnormality of alkaline phosphatase activity (HP:0004379)1.81337045
177Bicornuate uterus (HP:0000813)1.79299897
178Thin bony cortex (HP:0002753)1.78980038
179Nausea (HP:0002018)1.69166001
180Irritability (HP:0000737)1.65353446
181Generalized muscle weakness (HP:0003324)1.65075693
182Abnormality of the costochondral junction (HP:0000919)1.64906820
183Metaphyseal irregularity (HP:0003025)1.64423780
184Lymphangioma (HP:0100764)1.63396331
185Abnormality of carpal bone ossification (HP:0006257)1.60395861
186Glomerulosclerosis (HP:0000096)1.60041363
187Neonatal onset (HP:0003623)1.58507009
188Abnormal eating behavior (HP:0100738)1.54977183
189Tachypnea (HP:0002789)1.53197333
190Axonal loss (HP:0003447)1.51084039
191Metaphyseal dysplasia (HP:0100255)1.46266441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK39.41962738
2WNK47.98260985
3OXSR17.67493251
4ITK6.85677917
5RIPK43.98160316
6STK393.83085930
7TXK3.21469559
8MAP4K22.96889374
9BLK2.71474149
10BCKDK2.64889825
11TNK22.35479033
12STK38L2.31969500
13BTK2.26536906
14CDK122.19057112
15FES2.15446078
16SYK2.08818078
17IRAK42.07645706
18TAOK31.99953011
19PDK21.98282316
20PDK41.87700121
21PDK31.87700121
22ZAP701.87109368
23SGK4941.86834213
24SGK2231.86834213
25TLK11.86221556
26MARK31.80088248
27NEK11.74636626
28MAP3K101.66881484
29WNK11.62997673
30BRD41.59987152
31HCK1.53698949
32TEC1.52126596
33IKBKE1.51665914
34MST1R1.49420982
35LCK1.43412732
36LYN1.41938779
37MST41.37394375
38JAK31.36314403
39KIT1.35703424
40IKBKB1.33118252
41CAMKK21.32570207
42ACVR1B1.30638981
43NLK1.22406592
44STK381.19538473
45TBK11.16401900
46CAMKK11.09710597
47TESK21.07691891
48SGK21.06586696
49FGFR41.06526747
50SIK21.05924902
51SGK31.01697013
52PRPF4B0.99989196
53MAPK70.99691106
54LRRK20.96517517
55JAK10.95642272
56CSF1R0.93953395
57PINK10.93026461
58FGFR30.89206705
59PASK0.83378059
60ERN10.82210187
61HIPK20.81256608
62EPHB10.74239486
63GSK3A0.73705352
64MAP3K30.70096636
65SMG10.69101983
66PIK3CG0.68314333
67CHUK0.67843946
68TGFBR20.67572829
69CDK40.67012888
70GRK60.66371760
71TIE10.63025023
72CDC42BPA0.62969052
73MAP3K10.61958450
74FGR0.60642561
75MELK0.58671837
76MAP3K70.58593089
77SGK10.57339265
78MARK20.55197862
79TAOK10.54716396
80DYRK1B0.54568201
81INSRR0.52888264
82BMPR20.50792187
83PTK20.50371623
84PRKAA10.50250993
85SIK30.50069571
86MAP2K60.48794359
87PDPK10.47965711
88MET0.44917562
89FER0.41422546
90RPS6KA60.40385438
91BMPR1B0.40343957
92PTK60.39200305
93PRKAA20.38699361
94ABL20.37611799
95STK100.37190074
96MAPK110.37157038
97PAK40.35868807
98LATS10.35221562
99TRIB30.35126709
100FGFR20.34921021
101CDK30.33562645
102PDK10.33328183
103MAPK150.33274545
104MAP3K20.32923509
105PAK30.32679882
106NUAK10.32494047
107ADRBK20.32239234
108PRKCI0.32115287
109MAP3K140.32048517
110KSR20.31893488
111RPS6KC10.31231086
112RPS6KL10.31231086
113PRKD20.30464690
114ADRBK10.27789473
115PRKCZ0.26965525
116YES10.26880033
117JAK20.24262187
118STK110.23144887
119PRKCD0.22714174
120NEK90.21909037
121IRAK20.21853214
122NTRK10.20897128
123PRKACG0.20868671
124FRK0.20144891
125PTK2B0.19925990
126RIPK10.16684039
127MAPK120.16351891
128PRKCH0.15293689
129EPHA40.15175601
130IRAK10.14766149
131PRKCA0.14106017
132AKT20.13195396
133ERBB40.11768596
134PIM10.11205776
135PRKACA0.11143698
136MAP2K20.08948354
137MAP3K130.06843773
138MYLK0.06430356
139TGFBR10.06415569
140MINK10.06232148
141INSR0.06021983
142MAP4K10.05611126
143IGF1R0.04860007
144BMX0.04390955
145MAP3K110.03921949
146IRAK30.03913600
147MAP2K30.03577333
148CSNK1A10.03262938
149CAMK40.03121777
150NME20.02785657
151SRC0.02329826
152PRKD30.02078058
153PDGFRA0.01916291
154EPHB20.01892648
155PRKCQ0.01801705
156MATK0.01735991
157CSK0.01570543
158MTOR0.01012332
159ROCK10.00525045
160TYK2-0.0072892
161RPS6KA3-0.0043003
162MAP2K1-0.0015949

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.45534412
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.92779650
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.60628051
4Allograft rejection_Homo sapiens_hsa053303.53233578
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.52893296
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.50330678
7Butanoate metabolism_Homo sapiens_hsa006503.44465296
8Autoimmune thyroid disease_Homo sapiens_hsa053203.23386128
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.22144580
10Intestinal immune network for IgA production_Homo sapiens_hsa046723.17556704
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.14458335
12Propanoate metabolism_Homo sapiens_hsa006403.00017053
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93662402
14Graft-versus-host disease_Homo sapiens_hsa053322.70134385
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57892050
16T cell receptor signaling pathway_Homo sapiens_hsa046602.52006484
17Vitamin digestion and absorption_Homo sapiens_hsa049772.47410758
18Asthma_Homo sapiens_hsa053102.46196727
19Peroxisome_Homo sapiens_hsa041462.45275106
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44860715
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.39781903
22B cell receptor signaling pathway_Homo sapiens_hsa046622.39703403
23Tryptophan metabolism_Homo sapiens_hsa003802.34232158
24Fatty acid degradation_Homo sapiens_hsa000712.28930361
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.19708829
26Osteoclast differentiation_Homo sapiens_hsa043802.14891500
27Pyruvate metabolism_Homo sapiens_hsa006202.12647605
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.12050922
29Collecting duct acid secretion_Homo sapiens_hsa049662.11466840
30Hematopoietic cell lineage_Homo sapiens_hsa046402.10553859
31Leishmaniasis_Homo sapiens_hsa051402.10474379
32Type I diabetes mellitus_Homo sapiens_hsa049402.03030046
33Antigen processing and presentation_Homo sapiens_hsa046121.95059467
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.92435749
35Measles_Homo sapiens_hsa051621.90454242
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.89369102
37Bile secretion_Homo sapiens_hsa049761.84982690
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84342484
39beta-Alanine metabolism_Homo sapiens_hsa004101.83787604
40Staphylococcus aureus infection_Homo sapiens_hsa051501.80511773
41Sulfur metabolism_Homo sapiens_hsa009201.73408198
42Glutathione metabolism_Homo sapiens_hsa004801.69884222
43Fatty acid metabolism_Homo sapiens_hsa012121.68003459
44Carbon metabolism_Homo sapiens_hsa012001.63206611
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61134908
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58226921
47Herpes simplex infection_Homo sapiens_hsa051681.50700078
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.49843594
49Acute myeloid leukemia_Homo sapiens_hsa052211.48986522
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48155807
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47509551
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42678944
53Protein digestion and absorption_Homo sapiens_hsa049741.41675220
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40609819
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40380432
56Lysine degradation_Homo sapiens_hsa003101.37903533
57Arginine biosynthesis_Homo sapiens_hsa002201.37285547
58Tuberculosis_Homo sapiens_hsa051521.34793377
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32083160
60PPAR signaling pathway_Homo sapiens_hsa033201.31334162
61Other glycan degradation_Homo sapiens_hsa005111.31327599
62Toxoplasmosis_Homo sapiens_hsa051451.29634728
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26131220
64Nitrogen metabolism_Homo sapiens_hsa009101.24999144
65Influenza A_Homo sapiens_hsa051641.24747746
66Arginine and proline metabolism_Homo sapiens_hsa003301.23384039
67Chemokine signaling pathway_Homo sapiens_hsa040621.21417493
68Malaria_Homo sapiens_hsa051441.20189369
69Viral myocarditis_Homo sapiens_hsa054161.19308226
70Mineral absorption_Homo sapiens_hsa049781.19043570
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11140482
72Biosynthesis of amino acids_Homo sapiens_hsa012301.10417431
73Selenocompound metabolism_Homo sapiens_hsa004501.10134704
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03810915
75TNF signaling pathway_Homo sapiens_hsa046681.03219109
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02837729
77Non-small cell lung cancer_Homo sapiens_hsa052231.01188853
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01170604
79Starch and sucrose metabolism_Homo sapiens_hsa005001.00893223
80Platelet activation_Homo sapiens_hsa046110.98715458
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.96930170
82African trypanosomiasis_Homo sapiens_hsa051430.96475756
83Epstein-Barr virus infection_Homo sapiens_hsa051690.95844363
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88924485
85Folate biosynthesis_Homo sapiens_hsa007900.88850332
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88652233
87Hepatitis B_Homo sapiens_hsa051610.86543043
88Fructose and mannose metabolism_Homo sapiens_hsa000510.85839001
89FoxO signaling pathway_Homo sapiens_hsa040680.82733200
90Histidine metabolism_Homo sapiens_hsa003400.81723509
91Fatty acid elongation_Homo sapiens_hsa000620.81161670
92Glycerolipid metabolism_Homo sapiens_hsa005610.80575893
93VEGF signaling pathway_Homo sapiens_hsa043700.80517348
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80051698
95Renin-angiotensin system_Homo sapiens_hsa046140.77391297
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76847108
97Lysosome_Homo sapiens_hsa041420.76777781
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76215027
99Linoleic acid metabolism_Homo sapiens_hsa005910.75446875
100Regulation of autophagy_Homo sapiens_hsa041400.73743120
101Phenylalanine metabolism_Homo sapiens_hsa003600.73134564
102Viral carcinogenesis_Homo sapiens_hsa052030.72939954
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.72736824
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71984130
105Dorso-ventral axis formation_Homo sapiens_hsa043200.70419305
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.69844572
107Apoptosis_Homo sapiens_hsa042100.69690466
108Oxidative phosphorylation_Homo sapiens_hsa001900.69426865
109Pancreatic cancer_Homo sapiens_hsa052120.69175691
110Chemical carcinogenesis_Homo sapiens_hsa052040.67721984
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67429381
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67153231
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.64404161
114Colorectal cancer_Homo sapiens_hsa052100.64375673
115Prolactin signaling pathway_Homo sapiens_hsa049170.63420675
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63018939
117Legionellosis_Homo sapiens_hsa051340.62642405
118Renal cell carcinoma_Homo sapiens_hsa052110.61284833
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.60963441
120HTLV-I infection_Homo sapiens_hsa051660.60595134
121Thyroid hormone synthesis_Homo sapiens_hsa049180.58566954
122Systemic lupus erythematosus_Homo sapiens_hsa053220.57846682
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.56494007
124Pentose phosphate pathway_Homo sapiens_hsa000300.54073923
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51221747
126Metabolic pathways_Homo sapiens_hsa011000.51118573
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50391005
128MAPK signaling pathway_Homo sapiens_hsa040100.48870694
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48572470
130Phagosome_Homo sapiens_hsa041450.47925562
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.47820490
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.47597285
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.46895086
134Gastric acid secretion_Homo sapiens_hsa049710.46555105
135Chronic myeloid leukemia_Homo sapiens_hsa052200.45989081
136Prostate cancer_Homo sapiens_hsa052150.45585774
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.42291059
138Endometrial cancer_Homo sapiens_hsa052130.41622465
139RNA polymerase_Homo sapiens_hsa030200.41413441
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41293057
141Retinol metabolism_Homo sapiens_hsa008300.40824220
142Arachidonic acid metabolism_Homo sapiens_hsa005900.39028777
143Shigellosis_Homo sapiens_hsa051310.36605757
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36601143
145Homologous recombination_Homo sapiens_hsa034400.34411665
146Parkinsons disease_Homo sapiens_hsa050120.33929030
147Tyrosine metabolism_Homo sapiens_hsa003500.30718321
148Vibrio cholerae infection_Homo sapiens_hsa051100.29750530
149mTOR signaling pathway_Homo sapiens_hsa041500.28674589
150Caffeine metabolism_Homo sapiens_hsa002320.28206985
151Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27328909
152Endocytosis_Homo sapiens_hsa041440.27274508
153Pertussis_Homo sapiens_hsa051330.26273328
154Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25598675
155ABC transporters_Homo sapiens_hsa020100.25531678
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25310770
157Sulfur relay system_Homo sapiens_hsa041220.25166708
158Sphingolipid metabolism_Homo sapiens_hsa006000.23153639
159Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21515921
160Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20208186
161Choline metabolism in cancer_Homo sapiens_hsa052310.19867980
162Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16419859
163Synaptic vesicle cycle_Homo sapiens_hsa047210.15687204
164Cardiac muscle contraction_Homo sapiens_hsa042600.14860657
165Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12424965
166Insulin resistance_Homo sapiens_hsa049310.11691243
167Alzheimers disease_Homo sapiens_hsa050100.11041301
168Steroid biosynthesis_Homo sapiens_hsa001000.10213924
169Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.08404987
170Adipocytokine signaling pathway_Homo sapiens_hsa049200.07680663
171Hedgehog signaling pathway_Homo sapiens_hsa043400.05028718
172Inositol phosphate metabolism_Homo sapiens_hsa005620.02737957
173Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02397201
174Bladder cancer_Homo sapiens_hsa052190.02229251
175Rheumatoid arthritis_Homo sapiens_hsa053230.00618153
176Huntingtons disease_Homo sapiens_hsa05016-0.0538141
177Glucagon signaling pathway_Homo sapiens_hsa04922-0.0378518
178Galactose metabolism_Homo sapiens_hsa00052-0.0350240
179Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0150352
180AMPK signaling pathway_Homo sapiens_hsa04152-0.0131710
181Hepatitis C_Homo sapiens_hsa05160-0.0045033

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