SLC5A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040]. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-amino acid import (GO:0043092)6.98963876
2modified amino acid transport (GO:0072337)6.96857867
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.88300593
4folic acid transport (GO:0015884)5.88106506
5synaptic vesicle maturation (GO:0016188)5.80988821
6amino acid import (GO:0043090)5.78148948
7sodium ion export (GO:0071436)5.65575654
8glutamate secretion (GO:0014047)5.57641475
9folic acid metabolic process (GO:0046655)5.56219445
10cellular potassium ion homeostasis (GO:0030007)5.55551006
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47386094
12synaptic vesicle exocytosis (GO:0016079)5.21426052
13purine nucleobase biosynthetic process (GO:0009113)5.08436629
14urate metabolic process (GO:0046415)5.01362065
15drug transport (GO:0015893)5.00257739
16drug transmembrane transport (GO:0006855)4.88338689
17serine family amino acid biosynthetic process (GO:0009070)4.87989744
18angiotensin maturation (GO:0002003)4.82804885
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.56311065
20oligosaccharide catabolic process (GO:0009313)4.56079094
21fructose metabolic process (GO:0006000)4.51342726
22intestinal absorption (GO:0050892)4.49198564
23regulation of synaptic vesicle exocytosis (GO:2000300)4.44461938
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.40795038
25vitamin transport (GO:0051180)4.29552373
26glycine transport (GO:0015816)4.28842975
27nucleobase biosynthetic process (GO:0046112)4.28154102
28L-serine metabolic process (GO:0006563)4.24898157
29heme transport (GO:0015886)4.23559714
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.22931608
31neurotransmitter secretion (GO:0007269)4.20032455
32ribosome assembly (GO:0042255)4.15904065
33neuronal ion channel clustering (GO:0045161)4.13474621
34myelin maintenance (GO:0043217)4.12176735
35drug catabolic process (GO:0042737)4.05281643
36cellular sodium ion homeostasis (GO:0006883)4.04531895
37cysteine metabolic process (GO:0006534)3.99870192
38intestinal epithelial cell development (GO:0060576)3.97105531
39regulation of neuronal synaptic plasticity (GO:0048168)3.96566222
40potassium ion import (GO:0010107)3.96329323
41potassium ion homeostasis (GO:0055075)3.95885571
42nonribosomal peptide biosynthetic process (GO:0019184)3.95497445
43NADH metabolic process (GO:0006734)3.94539204
44serine family amino acid metabolic process (GO:0009069)3.93643431
45vitamin transmembrane transport (GO:0035461)3.89371667
46neurotransmitter transport (GO:0006836)3.86858605
47cerebellar granule cell differentiation (GO:0021707)3.85775447
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.85037921
49regulation of synaptic vesicle transport (GO:1902803)3.84575204
50glutathione biosynthetic process (GO:0006750)3.81152102
51polyol transport (GO:0015791)3.78415074
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.72914577
53interferon-gamma secretion (GO:0072643)3.72656669
54phosphate ion transport (GO:0006817)3.68971543
55intestinal cholesterol absorption (GO:0030299)3.68832973
56positive regulation of synapse maturation (GO:0090129)3.67854733
57sulfur compound transport (GO:0072348)3.67695933
58long-chain fatty acid biosynthetic process (GO:0042759)3.62587246
59locomotory exploration behavior (GO:0035641)3.61476855
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.60896565
61neuronal action potential propagation (GO:0019227)3.59810240
62organic cation transport (GO:0015695)3.58692215
63CDP-diacylglycerol metabolic process (GO:0046341)3.58444387
64alditol metabolic process (GO:0019400)3.57696494
65acidic amino acid transport (GO:0015800)3.57008733
66central nervous system myelination (GO:0022010)3.54386363
67axon ensheathment in central nervous system (GO:0032291)3.54386363
68aminoglycoside antibiotic metabolic process (GO:0030647)3.52243609
69cofactor transport (GO:0051181)3.49667449
70sphingomyelin metabolic process (GO:0006684)3.46426589
71phosphate ion homeostasis (GO:0055062)3.45441187
72trivalent inorganic anion homeostasis (GO:0072506)3.45441187
73phosphate ion transmembrane transport (GO:0035435)3.45091391
74serine family amino acid catabolic process (GO:0009071)3.43523360
75excretion (GO:0007588)3.40941282
76regulation of long-term neuronal synaptic plasticity (GO:0048169)3.37713975
77L-methionine salvage (GO:0071267)3.36092655
78L-methionine biosynthetic process (GO:0071265)3.36092655
79amino acid salvage (GO:0043102)3.36092655
80regulation of bile acid biosynthetic process (GO:0070857)3.35760107
81regulation of female receptivity (GO:0045924)3.35306850
82response to mercury ion (GO:0046689)3.34341975
83peptide biosynthetic process (GO:0043043)3.31830347
84positive regulation of dendritic spine development (GO:0060999)3.30295774
85drinking behavior (GO:0042756)3.29698965
86amino sugar catabolic process (GO:0046348)3.29076881
87sulfur amino acid biosynthetic process (GO:0000097)3.27905996
88regulation of ARF protein signal transduction (GO:0032012)3.27009152
89phosphorelay signal transduction system (GO:0000160)3.26863671
90cerebellar Purkinje cell differentiation (GO:0021702)3.26823351
91regulation of synaptic plasticity (GO:0048167)3.25308167
92regulation of guanylate cyclase activity (GO:0031282)3.24547113
93negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24439312
94homocysteine metabolic process (GO:0050667)3.23801227
95L-glutamate transport (GO:0015813)3.23318781
96regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.22512314
97proline transport (GO:0015824)3.22161268
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21865939
99response to phenylpropanoid (GO:0080184)3.21199314
100pantothenate metabolic process (GO:0015939)3.20238051
101neurotransmitter uptake (GO:0001504)3.18801949
102presynaptic membrane organization (GO:0097090)3.18100278
103vocalization behavior (GO:0071625)3.18089203
104regulation of neurotransmitter levels (GO:0001505)3.17342162
105exogenous drug catabolic process (GO:0042738)3.16437841
106glutathione derivative biosynthetic process (GO:1901687)3.16426824
107glutathione derivative metabolic process (GO:1901685)3.16426824
108labyrinthine layer development (GO:0060711)3.16200325
109exploration behavior (GO:0035640)3.15544297
110cholesterol biosynthetic process (GO:0006695)3.13616303
111neuron-neuron synaptic transmission (GO:0007270)3.12768987
112lysine catabolic process (GO:0006554)3.12026679
113lysine metabolic process (GO:0006553)3.12026679
114synaptic transmission, glutamatergic (GO:0035249)3.11739331
115cell communication by electrical coupling (GO:0010644)3.09120003
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08263033
117proteasome assembly (GO:0043248)3.08072339
118myelination (GO:0042552)3.07494602
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06855851
120vitamin D metabolic process (GO:0042359)3.06035124
121regulation of voltage-gated calcium channel activity (GO:1901385)3.04780973
122renal absorption (GO:0070293)3.03175268
123calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.02306490
124glycine metabolic process (GO:0006544)3.01255062
125axon ensheathment (GO:0008366)3.01063727
126ensheathment of neurons (GO:0007272)3.01063727
127glutamate receptor signaling pathway (GO:0007215)3.00833016
128lung-associated mesenchyme development (GO:0060484)2.99727715
129negative regulation of dendrite morphogenesis (GO:0050774)2.99391783
130biotin metabolic process (GO:0006768)2.99102072
131lipoprotein transport (GO:0042953)2.98943835
132long-term synaptic potentiation (GO:0060291)2.97528583
133fatty acid elongation (GO:0030497)2.95929039
134sperm capacitation (GO:0048240)2.94778024
135proline metabolic process (GO:0006560)2.94295917
136neurotransmitter-gated ion channel clustering (GO:0072578)2.93868614
137CDP-diacylglycerol biosynthetic process (GO:0016024)2.93813185
138folic acid-containing compound metabolic process (GO:0006760)2.93745026
139gamma-aminobutyric acid transport (GO:0015812)2.93724005
140aspartate family amino acid catabolic process (GO:0009068)2.93242086
141female mating behavior (GO:0060180)2.92429520
142positive regulation of cellular amine metabolic process (GO:0033240)2.89952547
143regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.89590159
144regulation of glutamate receptor signaling pathway (GO:1900449)2.89577666
145iron coordination entity transport (GO:1901678)2.89534365
146substantia nigra development (GO:0021762)2.89057065
147regulation of dendritic spine morphogenesis (GO:0061001)2.88493547
148presynaptic membrane assembly (GO:0097105)2.88487382
149mitotic metaphase plate congression (GO:0007080)2.88165811
150relaxation of smooth muscle (GO:0044557)2.88140121
151postsynaptic membrane organization (GO:0001941)2.87780139
152branched-chain amino acid catabolic process (GO:0009083)2.87633449
153sulfur amino acid metabolic process (GO:0000096)2.87332427
154positive regulation of membrane potential (GO:0045838)2.86993475
155peptide catabolic process (GO:0043171)2.84571392
156sterol biosynthetic process (GO:0016126)2.84374982
157neuromuscular process controlling balance (GO:0050885)2.84143437
158termination of RNA polymerase III transcription (GO:0006386)2.83547610
159transcription elongation from RNA polymerase III promoter (GO:0006385)2.83547610
160cytoskeletal anchoring at plasma membrane (GO:0007016)2.83404520
161sodium ion homeostasis (GO:0055078)2.82951242
162synaptic vesicle endocytosis (GO:0048488)2.82590078
163regulation of excitatory postsynaptic membrane potential (GO:0060079)2.81944154
164phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.80511431
165creatine metabolic process (GO:0006600)2.80022933
166long-term memory (GO:0007616)2.79859132
167quaternary ammonium group transport (GO:0015697)2.79185642
168regulation of synapse maturation (GO:0090128)2.78974917
169branched-chain amino acid metabolic process (GO:0009081)2.78602169
170positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78056578
171regulation of neurotransmitter secretion (GO:0046928)2.76991226
172C4-dicarboxylate transport (GO:0015740)2.76018760
173cellular response to nitric oxide (GO:0071732)2.75048050
174adult walking behavior (GO:0007628)2.74109235
175formation of translation preinitiation complex (GO:0001731)2.73814342
176glycerol metabolic process (GO:0006071)2.73694485
177virion attachment to host cell (GO:0019062)2.72885708
178adhesion of symbiont to host cell (GO:0044650)2.72885708
179triglyceride biosynthetic process (GO:0019432)2.72101889
180cellular carbohydrate catabolic process (GO:0044275)2.71798697
181positive regulation of dendritic spine morphogenesis (GO:0061003)2.71168129
182positive regulation of guanylate cyclase activity (GO:0031284)2.70769859
183regulation of calcium ion-dependent exocytosis (GO:0017158)2.70719517
184regulation of dendritic spine development (GO:0060998)2.70079044
185layer formation in cerebral cortex (GO:0021819)2.69356358
186cobalamin metabolic process (GO:0009235)2.69170535
187regulation of lipoprotein metabolic process (GO:0050746)2.68636768
188glyoxylate metabolic process (GO:0046487)2.68571135
189regulation of DNA methylation (GO:0044030)2.68551540
190water-soluble vitamin metabolic process (GO:0006767)2.67341989
191neuron cell-cell adhesion (GO:0007158)2.67331684
192anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.66847811
193sulfate transmembrane transport (GO:1902358)2.66616997
194aspartate family amino acid metabolic process (GO:0009066)2.66065429
195water-soluble vitamin biosynthetic process (GO:0042364)2.63968478
196regulation of cellular amino acid metabolic process (GO:0006521)2.61942191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.97157441
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.24605504
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19400950
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18291166
5DROSHA_22980978_ChIP-Seq_HELA_Human3.16764131
6AR_21909140_ChIP-Seq_LNCAP_Human3.14777476
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06124987
8E2F7_22180533_ChIP-Seq_HELA_Human3.03430317
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.88059851
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82065544
11NANOG_18555785_ChIP-Seq_MESCs_Mouse2.81472286
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.65774125
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.59115287
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.56893348
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.56605316
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.51011403
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46959281
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38161362
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38130270
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37994126
21* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35976476
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32238703
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.30558489
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.29476550
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28002363
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27628209
27TP63_17297297_ChIP-ChIP_HaCaT_Human2.23649659
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22797040
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20172000
30MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19727741
31* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.14313461
32GABP_17652178_ChIP-ChIP_JURKAT_Human2.13861239
33TCF3_18692474_ChIP-Seq_MEFs_Mouse2.13786152
34EST1_17652178_ChIP-ChIP_JURKAT_Human2.09892758
35MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06813221
36* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03208024
37YY1_21170310_ChIP-Seq_MESCs_Mouse2.02759015
38STAT3_1855785_ChIP-Seq_MESCs_Mouse2.00128493
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99634002
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.94190529
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93392732
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.91640332
43GBX2_23144817_ChIP-Seq_PC3_Human1.91148494
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91084684
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.88361936
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87903309
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85868864
48* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.84430336
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84106934
50* REST_18959480_ChIP-ChIP_MESCs_Mouse1.79389831
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78999239
52NANOG_18692474_ChIP-Seq_MEFs_Mouse1.78305462
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75020645
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.74971820
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73450061
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71404039
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71404039
58ZNF263_19887448_ChIP-Seq_K562_Human1.70177857
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65245538
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.64708153
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.63988572
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.63524090
63SOX2_18692474_ChIP-Seq_MEFs_Mouse1.63039386
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61898853
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60689517
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60300075
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60300075
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60300075
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58801143
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54676804
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53942980
72VDR_23849224_ChIP-Seq_CD4+_Human1.53543823
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.52648518
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52488559
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50966275
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50917638
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50332449
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47843480
79OCT4_18692474_ChIP-Seq_MEFs_Mouse1.46596386
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.44439661
81* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.44218136
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44098551
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44039450
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.41878673
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40896882
86* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40080596
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37449576
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36700097
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35787927
90XRN2_22483619_ChIP-Seq_HELA_Human1.35291593
91GATA4_25053715_ChIP-Seq_YYC3_Human1.34892422
92* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34760149
93* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.34119035
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32948691
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32405381
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31779204
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30782956
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30583959
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30069163
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28960060
101IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28803072
102* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27561153
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26720861
104GABP_19822575_ChIP-Seq_HepG2_Human1.24845029
105TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.23071817
106* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.22665500
107* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22480054
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21678525
109ESR2_21235772_ChIP-Seq_MCF-7_Human1.21137416
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21044028
111EED_16625203_ChIP-ChIP_MESCs_Mouse1.20421544
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.20242095
113* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19765172
114SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18219713
115* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17624978
116CDX2_20551321_ChIP-Seq_CACO-2_Human1.16214414
117* KAP1_27257070_Chip-Seq_ESCs_Mouse1.15018181
118KDM2B_26808549_Chip-Seq_K562_Human1.14545415
119RXR_22158963_ChIP-Seq_LIVER_Mouse1.13962585
120KDM5A_27292631_Chip-Seq_BREAST_Human1.13252803
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12244652
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11343436
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10939074
124KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10539453
125OCT4_19829295_ChIP-Seq_ESCs_Human1.09531819
126* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09029420
127DCP1A_22483619_ChIP-Seq_HELA_Human1.07885590
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07607716
129TCF4_23295773_ChIP-Seq_U87_Human1.05908809
130GATA6_25053715_ChIP-Seq_YYC3_Human1.05511423
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05279480
132* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05129695
133FOXA2_19822575_ChIP-Seq_HepG2_Human1.04705541
134PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04222303
135FOXP3_21729870_ChIP-Seq_TREG_Human1.04150954
136SMAD4_21799915_ChIP-Seq_A2780_Human1.02762718
137SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02730134
138BP1_19119308_ChIP-ChIP_Hs578T_Human1.02534429
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01698217
140ELK1_22589737_ChIP-Seq_MCF10A_Human1.01465224
141* SOX2_21211035_ChIP-Seq_LN229_Gbm1.01443631
142ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01254819
143* AR_19668381_ChIP-Seq_PC3_Human1.00825174
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00738052
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99873974
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99153747
147TET1_21490601_ChIP-Seq_MESCs_Mouse0.98251942
148EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98145650
149NANOG_21062744_ChIP-ChIP_HESCs_Human0.97426523
150THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97351405
151SOX17_20123909_ChIP-Seq_XEN_Mouse0.97164490
152* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97075520
153NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96957155
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96840547
155KLF4_19829295_ChIP-Seq_ESCs_Human0.96415475
156ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96266993
157ERG_21242973_ChIP-ChIP_JURKAT_Human0.95599720
158VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95416685
159POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95159730
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.94948632
161GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94553602
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.94450139
163FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93741030
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93614641
165SALL1_21062744_ChIP-ChIP_HESCs_Human0.93576933
166CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93553773
167GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92214866
168LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92061202
169PRDM14_20953172_ChIP-Seq_ESCs_Human0.91958140
170AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91943255
171CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91162935
172* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90201179
173ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90079614
174* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89854605
175STAT3_23295773_ChIP-Seq_U87_Human0.89852283
176ATF3_27146783_Chip-Seq_COLON_Human0.89839692
177SMAD3_21741376_ChIP-Seq_EPCs_Human0.89488293
178YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89415820
179KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89336619
180CTCF_27219007_Chip-Seq_Bcells_Human0.87606763
181SMAD_19615063_ChIP-ChIP_OVARY_Human0.86544653
182EP300_21415370_ChIP-Seq_HL-1_Mouse0.86277893
183GF1_26923725_Chip-Seq_HPCs_Mouse0.86220315
184NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85640351
185RING1B_27294783_Chip-Seq_ESCs_Mouse0.85212643
186SMAD3_21741376_ChIP-Seq_HESCs_Human0.83033145
187AHR_22903824_ChIP-Seq_MCF-7_Human0.81912765
188* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81740774
189SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80902121
190RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80003528
191LXR_22292898_ChIP-Seq_THP-1_Human0.78836934
192OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.78551219
193AR_21572438_ChIP-Seq_LNCaP_Human0.77671263
194MYC_19915707_ChIP-ChIP_AK7_Human0.76819371
195LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76212550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.61279084
2MP0009840_abnormal_foam_cell5.46738951
3MP0004859_abnormal_synaptic_plasticity4.89613833
4MP0004270_analgesia4.87745418
5MP0004019_abnormal_vitamin_homeostasis4.33005352
6MP0004043_abnormal_pH_regulation4.06305214
7MP0003880_abnormal_central_pattern3.97875116
8MP0003693_abnormal_embryo_hatching3.76891853
9MP0005332_abnormal_amino_acid3.57956205
10MP0005377_hearing/vestibular/ear_phenot3.45628868
11MP0003878_abnormal_ear_physiology3.45628868
12MP0002064_seizures3.43186094
13MP0003635_abnormal_synaptic_transmissio3.32751211
14MP0002272_abnormal_nervous_system3.22122929
15MP0005423_abnormal_somatic_nervous3.14690760
16MP0003718_maternal_effect3.08180260
17MP0003806_abnormal_nucleotide_metabolis2.99708326
18MP0001486_abnormal_startle_reflex2.96909057
19MP0009745_abnormal_behavioral_response2.71603732
20MP0001666_abnormal_nutrient_absorption2.60051113
21MP0009643_abnormal_urine_homeostasis2.59527742
22MP0002063_abnormal_learning/memory/cond2.54865176
23MP0002734_abnormal_mechanical_nocicepti2.52489155
24MP0008260_abnormal_autophagy2.50406874
25MP0002139_abnormal_hepatobiliary_system2.47409701
26MP0001501_abnormal_sleep_pattern2.42451891
27MP0003195_calcinosis2.41359252
28MP0004957_abnormal_blastocyst_morpholog2.35934575
29MP0008569_lethality_at_weaning2.34414872
30MP0003111_abnormal_nucleus_morphology2.27748651
31MP0001756_abnormal_urination2.18832990
32MP0009046_muscle_twitch2.18681073
33MP0005058_abnormal_lysosome_morphology2.12789260
34MP0002572_abnormal_emotion/affect_behav2.07927513
35MP0001765_abnormal_ion_homeostasis1.98653054
36MP0008875_abnormal_xenobiotic_pharmacok1.96065603
37MP0005451_abnormal_body_composition1.87539430
38MP0001968_abnormal_touch/_nociception1.86579614
39MP0002136_abnormal_kidney_physiology1.80833541
40MP0002735_abnormal_chemical_nociception1.79008800
41MP0004264_abnormal_extraembryonic_tissu1.78143787
42MP0005636_abnormal_mineral_homeostasis1.76080710
43MP0000566_synostosis1.74162921
44MP0003329_amyloid_beta_deposits1.73497887
45MP0003186_abnormal_redox_activity1.72424084
46MP0003950_abnormal_plasma_membrane1.72091238
47MP0004885_abnormal_endolymph1.70880046
48MP0003633_abnormal_nervous_system1.67825664
49MP0009780_abnormal_chondrocyte_physiolo1.61538802
50MP0002067_abnormal_sensory_capabilities1.56069539
51MP0001970_abnormal_pain_threshold1.53640660
52MP0005646_abnormal_pituitary_gland1.50899168
53MP0005395_other_phenotype1.49217911
54MP0001440_abnormal_grooming_behavior1.46733093
55MP0003631_nervous_system_phenotype1.46286046
56MP0003315_abnormal_perineum_morphology1.44081233
57MP0002229_neurodegeneration1.41849184
58MP0002733_abnormal_thermal_nociception1.39775644
59MP0001764_abnormal_homeostasis1.38059011
60MP0002066_abnormal_motor_capabilities/c1.35410344
61MP0005085_abnormal_gallbladder_physiolo1.35091718
62MP0002796_impaired_skin_barrier1.33823332
63MP0000462_abnormal_digestive_system1.33535621
64MP0001661_extended_life_span1.32474524
65MP0009379_abnormal_foot_pigmentation1.31684594
66MP0001502_abnormal_circadian_rhythm1.31656592
67MP0004811_abnormal_neuron_physiology1.28497153
68MP0004924_abnormal_behavior1.27874372
69MP0005386_behavior/neurological_phenoty1.27874372
70MP0003077_abnormal_cell_cycle1.24943604
71MP0010678_abnormal_skin_adnexa1.24476808
72MP0002557_abnormal_social/conspecific_i1.23764588
73MP0005409_darkened_coat_color1.23329758
74MP0001986_abnormal_taste_sensitivity1.22351049
75MP0001730_embryonic_growth_arrest1.21275687
76MP0006035_abnormal_mitochondrial_morpho1.20067853
77MP0001905_abnormal_dopamine_level1.18727818
78MP0008932_abnormal_embryonic_tissue1.18225872
79MP0010329_abnormal_lipoprotein_level1.16529625
80MP0000920_abnormal_myelination1.16398084
81MP0002882_abnormal_neuron_morphology1.14659250
82MP0001984_abnormal_olfaction1.14225677
83MP0003634_abnormal_glial_cell1.13840034
84MP0006036_abnormal_mitochondrial_physio1.13499016
85MP0000778_abnormal_nervous_system1.13175517
86MP0003191_abnormal_cellular_cholesterol1.08929913
87MP0008057_abnormal_DNA_replication1.08508410
88MP0002736_abnormal_nociception_after1.05097556
89MP0006276_abnormal_autonomic_nervous1.04813927
90MP0010094_abnormal_chromosome_stability1.03789664
91MP0001963_abnormal_hearing_physiology1.03724613
92MP0001664_abnormal_digestion1.03666845
93MP0000604_amyloidosis0.99966018
94MP0005551_abnormal_eye_electrophysiolog0.99177207
95MP0005501_abnormal_skin_physiology0.98224532
96MP0002822_catalepsy0.97962795
97MP0008874_decreased_physiological_sensi0.97432563
98MP0002118_abnormal_lipid_homeostasis0.94200608
99MP0005319_abnormal_enzyme/_coenzyme0.93307093
100MP0003938_abnormal_ear_development0.92674507
101MP0003868_abnormal_feces_composition0.92351539
102MP0001177_atelectasis0.92324847
103MP0000955_abnormal_spinal_cord0.91724946
104MP0001485_abnormal_pinna_reflex0.91599654
105MP0005535_abnormal_body_temperature0.91583753
106MP0003183_abnormal_peptide_metabolism0.90498688
107MP0005365_abnormal_bile_salt0.90461108
108MP0004142_abnormal_muscle_tone0.89941670
109MP0008058_abnormal_DNA_repair0.89722535
110MP0000647_abnormal_sebaceous_gland0.89398623
111MP0003786_premature_aging0.87157215
112MP0003866_abnormal_defecation0.84790102
113MP0000383_abnormal_hair_follicle0.84595257
114MP0001529_abnormal_vocalization0.84473874
115MP0008877_abnormal_DNA_methylation0.84348754
116MP0002098_abnormal_vibrissa_morphology0.83918705
117MP0003123_paternal_imprinting0.83164091
118MP0004147_increased_porphyrin_level0.82824954
119MP0001727_abnormal_embryo_implantation0.81739652
120MP0010234_abnormal_vibrissa_follicle0.79631866
121MP0005166_decreased_susceptibility_to0.77969711
122MP0005584_abnormal_enzyme/coenzyme_acti0.77649886
123MP0003252_abnormal_bile_duct0.77292812
124MP0002152_abnormal_brain_morphology0.77100944
125MP0000490_abnormal_crypts_of0.76358556
126MP0001346_abnormal_lacrimal_gland0.75602966
127MP0003787_abnormal_imprinting0.75531545
128MP0003690_abnormal_glial_cell0.75256979
129MP0002069_abnormal_eating/drinking_beha0.74301573
130MP0005167_abnormal_blood-brain_barrier0.74261738
131MP0000377_abnormal_hair_follicle0.72674769
132MP0000747_muscle_weakness0.72237075
133MP0002089_abnormal_postnatal_growth/wei0.71434948
134MP0005084_abnormal_gallbladder_morpholo0.71006795
135MP0005380_embryogenesis_phenotype0.70204061
136MP0001672_abnormal_embryogenesis/_devel0.70204061
137MP0008872_abnormal_physiological_respon0.69619648
138MP0000538_abnormal_urinary_bladder0.69547064
139MP0000537_abnormal_urethra_morphology0.69250818
140MP0005266_abnormal_metabolism0.68638311
141MP0001542_abnormal_bone_strength0.68536663
142MP0000358_abnormal_cell_content/0.67489934
143MP0003941_abnormal_skin_development0.67145737
144MP0002876_abnormal_thyroid_physiology0.66397279
145MP0000609_abnormal_liver_physiology0.65887847
146MP0003656_abnormal_erythrocyte_physiolo0.65824240
147MP0001697_abnormal_embryo_size0.65753689
148MP0003075_altered_response_to0.64706177
149MP0010352_gastrointestinal_tract_polyps0.64702340
150MP0002080_prenatal_lethality0.63761090
151MP0003221_abnormal_cardiomyocyte_apopto0.62875866
152MP0004742_abnormal_vestibular_system0.61483845
153MP0000477_abnormal_intestine_morphology0.61434080
154MP0003632_abnormal_nervous_system0.60766564
155MP0002638_abnormal_pupillary_reflex0.59799492
156MP0003638_abnormal_response/metabolism_0.59217426
157MP0005394_taste/olfaction_phenotype0.59120651
158MP0005499_abnormal_olfactory_system0.59120651
159MP0001188_hyperpigmentation0.58088171
160MP0001293_anophthalmia0.56939116
161MP0005376_homeostasis/metabolism_phenot0.56891450
162MP0001145_abnormal_male_reproductive0.56707584
163MP0003879_abnormal_hair_cell0.55676503
164MP0001216_abnormal_epidermal_layer0.54832798
165MP0002161_abnormal_fertility/fecundity0.54716461
166MP0001958_emphysema0.54365495
167MP0005410_abnormal_fertilization0.54167446
168MP0002085_abnormal_embryonic_tissue0.53267600
169MP0005670_abnormal_white_adipose0.51404766
170MP0002254_reproductive_system_inflammat0.51258605
171MP0009333_abnormal_splenocyte_physiolog0.51105494

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.71221935
2Action tremor (HP:0002345)6.11838948
3Hyperglycinuria (HP:0003108)5.80328938
4Focal motor seizures (HP:0011153)5.39244352
5Increased circulating renin level (HP:0000848)5.19995344
6Abnormality of serine family amino acid metabolism (HP:0010894)5.12865223
7Abnormality of glycine metabolism (HP:0010895)5.12865223
8Metabolic alkalosis (HP:0200114)4.97693567
9Gout (HP:0001997)4.83973485
10Hypokalemic alkalosis (HP:0001949)4.72983208
11Neurofibrillary tangles (HP:0002185)4.70730448
12Supranuclear gaze palsy (HP:0000605)4.51694334
13Scanning speech (HP:0002168)4.49702693
14Febrile seizures (HP:0002373)4.49356367
15Proximal tubulopathy (HP:0000114)4.49355080
16Ankle clonus (HP:0011448)4.48708217
17Focal seizures (HP:0007359)4.42185272
18Hypomagnesemia (HP:0002917)4.39166300
19Atonic seizures (HP:0010819)4.23586645
20Hyperactive renin-angiotensin system (HP:0000841)4.19236133
21Ileus (HP:0002595)4.10268389
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10135807
23Abnormality of chloride homeostasis (HP:0011422)3.96248855
24Abnormality of magnesium homeostasis (HP:0004921)3.94419903
25Abnormal urine output (HP:0012590)3.89319642
26Hyperglycinemia (HP:0002154)3.86737195
27Degeneration of the lateral corticospinal tracts (HP:0002314)3.86441214
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.86441214
29Polyuria (HP:0000103)3.80946522
30Dysmetria (HP:0001310)3.75345404
31Epileptic encephalopathy (HP:0200134)3.72625998
32Renal salt wasting (HP:0000127)3.65581663
33Abnormality of renal excretion (HP:0011036)3.64780238
34Abnormality of the corticospinal tract (HP:0002492)3.61898056
35Abnormality of binocular vision (HP:0011514)3.60225028
36Diplopia (HP:0000651)3.60225028
37Megaloblastic anemia (HP:0001889)3.54407099
38Abnormal eating behavior (HP:0100738)3.48939048
39Spastic gait (HP:0002064)3.48702332
40Progressive cerebellar ataxia (HP:0002073)3.43568645
41Abnormality of urine glucose concentration (HP:0011016)3.39939182
42Glycosuria (HP:0003076)3.39939182
43Cerebral inclusion bodies (HP:0100314)3.37774079
44Breast hypoplasia (HP:0003187)3.34408409
45Dysdiadochokinesis (HP:0002075)3.34355999
46Increased purine levels (HP:0004368)3.33251687
47Hyperuricemia (HP:0002149)3.33251687
48Intention tremor (HP:0002080)3.30008493
49Postural instability (HP:0002172)3.19294303
50Prolonged neonatal jaundice (HP:0006579)3.17298713
51Hyperaldosteronism (HP:0000859)3.16465716
52Cerebral hypomyelination (HP:0006808)3.16224373
53Malnutrition (HP:0004395)2.96319887
54Alkalosis (HP:0001948)2.93758582
55Absence seizures (HP:0002121)2.89004847
56Confusion (HP:0001289)2.84652568
57Dysmetric saccades (HP:0000641)2.84169462
58Abnormality of purine metabolism (HP:0004352)2.82603932
59Urinary bladder sphincter dysfunction (HP:0002839)2.81654707
60Torticollis (HP:0000473)2.79653965
61Truncal ataxia (HP:0002078)2.78706429
62Abnormality of renin-angiotensin system (HP:0000847)2.77916471
63Rough bone trabeculation (HP:0100670)2.77832825
64Impaired vibration sensation in the lower limbs (HP:0002166)2.77754945
65Generalized tonic-clonic seizures (HP:0002069)2.77054712
66Widely patent fontanelles and sutures (HP:0004492)2.76485671
67Mutism (HP:0002300)2.74462768
68Apathy (HP:0000741)2.74255815
69Bundle branch block (HP:0011710)2.73941328
70Peripheral hypomyelination (HP:0007182)2.72102466
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71488102
72Delayed epiphyseal ossification (HP:0002663)2.65470191
73Abnormality of proline metabolism (HP:0010907)2.64118029
74Hydroxyprolinuria (HP:0003080)2.64118029
75Limb dystonia (HP:0002451)2.61433727
76Neuronal loss in central nervous system (HP:0002529)2.60886548
77Abnormal trabecular bone morphology (HP:0100671)2.59978353
78Dialeptic seizures (HP:0011146)2.59836197
79Urinary urgency (HP:0000012)2.57607243
80Spastic paraparesis (HP:0002313)2.55573130
81Methylmalonic aciduria (HP:0012120)2.54723312
82Carpal bone hypoplasia (HP:0001498)2.53230824
83Lethargy (HP:0001254)2.52495800
84Dicarboxylic aciduria (HP:0003215)2.48812809
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48812809
86Segmental peripheral demyelination/remyelination (HP:0003481)2.48436268
87Abnormality of the vitamin B12 metabolism (HP:0004341)2.47959047
88Diminished motivation (HP:0000745)2.47807555
89Clonus (HP:0002169)2.46418317
90CNS demyelination (HP:0007305)2.46393357
91Nausea (HP:0002018)2.46370818
92Abnormal drinking behavior (HP:0030082)2.45655178
93Polydipsia (HP:0001959)2.45655178
94Visual hallucinations (HP:0002367)2.44358318
95Lower limb muscle weakness (HP:0007340)2.44324371
96Tetany (HP:0001281)2.43803020
97Fat malabsorption (HP:0002630)2.43514722
98Postural tremor (HP:0002174)2.43329258
99Abnormality of fatty-acid metabolism (HP:0004359)2.43186989
100Abnormality of serum amino acid levels (HP:0003112)2.41788013
101Choreoathetosis (HP:0001266)2.41587121
102Focal dystonia (HP:0004373)2.41148397
103Rigidity (HP:0002063)2.39822955
104Obstructive sleep apnea (HP:0002870)2.39732362
105Hyperammonemia (HP:0001987)2.38007988
106Ureteral duplication (HP:0000073)2.37220327
107Abnormality of sulfur amino acid metabolism (HP:0004339)2.36164253
108Generalized aminoaciduria (HP:0002909)2.33408591
109Hyperphosphaturia (HP:0003109)2.32625101
110Vacuolated lymphocytes (HP:0001922)2.32050050
111Bradykinesia (HP:0002067)2.31997750
112Abnormality of saccadic eye movements (HP:0000570)2.31219023
113Tetraplegia (HP:0002445)2.31131508
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30332628
115Hypercalciuria (HP:0002150)2.28252844
116Abnormality of nucleobase metabolism (HP:0010932)2.27185821
117Xanthomatosis (HP:0000991)2.25341731
118Status epilepticus (HP:0002133)2.24561906
119Abnormality of vitamin B metabolism (HP:0004340)2.22631630
120Gaze-evoked nystagmus (HP:0000640)2.22275721
121Hemiplegia (HP:0002301)2.21285492
122Abnormal urine phosphate concentration (HP:0012599)2.21212544
123Akinesia (HP:0002304)2.20534152
124Impaired smooth pursuit (HP:0007772)2.19443254
125Birth length less than 3rd percentile (HP:0003561)2.18830996
126Dehydration (HP:0001944)2.18519877
127Abnormality of the umbilical cord (HP:0010881)2.18203248
128Delusions (HP:0000746)2.17293775
129Nephrolithiasis (HP:0000787)2.14630849
130Abnormality of glycolysis (HP:0004366)2.14289198
131Increased serum pyruvate (HP:0003542)2.14289198
132Impaired vibratory sensation (HP:0002495)2.14236782
133Hypobetalipoproteinemia (HP:0003563)2.13131949
134Abnormality of the distal phalanges of the toes (HP:0010182)2.10407436
135Craniofacial dystonia (HP:0012179)2.09846111
136Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07890655
137Memory impairment (HP:0002354)2.07821854
138Irritability (HP:0000737)2.06405563
139Depression (HP:0000716)2.05181107
140Abnormality of the periventricular white matter (HP:0002518)2.02980689
141CNS hypomyelination (HP:0003429)2.02151939
142Abnormality of ocular smooth pursuit (HP:0000617)2.01699928
143Annular pancreas (HP:0001734)2.01397007
144Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00003110
145Stridor (HP:0010307)1.99921629
146Aplasia/Hypoplasia involving the musculature (HP:0001460)1.99911940
147Steatorrhea (HP:0002570)1.99371587
148Hyponatremia (HP:0002902)1.98739802
149Dementia (HP:0000726)1.95363493
150Spastic tetraparesis (HP:0001285)1.94974919
151Abnormality of macrophages (HP:0004311)1.94580803
152Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93227044
153Vomiting (HP:0002013)1.92696813
154Congenital ichthyosiform erythroderma (HP:0007431)1.92644118
155Alacrima (HP:0000522)1.92223880
156Rickets (HP:0002748)1.91865093
157Epileptiform EEG discharges (HP:0011182)1.89805915
158Slow saccadic eye movements (HP:0000514)1.89483608
159Split foot (HP:0001839)1.88020848
160Hypokalemia (HP:0002900)1.86044181
161Hyperparathyroidism (HP:0000843)1.85958975
162Multiple enchondromatosis (HP:0005701)1.85582943
163Papilledema (HP:0001085)1.85058565
164Ventricular fibrillation (HP:0001663)1.84846082
165Death in infancy (HP:0001522)1.84509654
166Metaphyseal cupping (HP:0003021)1.84449244
167Vascular calcification (HP:0004934)1.83715283
168Abnormality of vitamin metabolism (HP:0100508)1.83241135
169Axonal loss (HP:0003447)1.82759619
170Insidious onset (HP:0003587)1.82677157
171Termporal pattern (HP:0011008)1.82677157
172Macrocytic anemia (HP:0001972)1.81011948
173Impulsivity (HP:0100710)1.80983401
174Metabolic acidosis (HP:0001942)1.80729199
175Abnormality of sodium homeostasis (HP:0010931)1.80554635
176Thickened helices (HP:0000391)1.78511284
177Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.78372481
178Athetosis (HP:0002305)1.77541867
179Abnormality of alkaline phosphatase activity (HP:0004379)1.77513035
180Heart block (HP:0012722)1.75932232
181Abnormal enzyme/coenzyme activity (HP:0012379)1.75917517
182Delayed CNS myelination (HP:0002188)1.75586653
183Sleep apnea (HP:0010535)1.73800175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.23569944
2BUB14.88362337
3EPHA44.55252502
4MAP3K94.08639959
5WEE13.96114323
6NTRK33.88846001
7OXSR13.70011348
8UHMK13.34799793
9WNK33.21162625
10PNCK3.09303957
11WNK43.06153538
12MAP3K132.76345201
13STK392.73434668
14PAK62.70196649
15MST42.69733522
16AKT32.62900057
17NTRK22.59521924
18STK162.54454030
19DAPK22.47127083
20TESK22.45589176
21TTK2.28714546
22NEK62.18429204
23EPHB12.13550184
24PRKD32.11933239
25KSR22.10441584
26RIPK11.98120842
27NEK11.97519880
28TSSK61.84374115
29CAMKK11.83780632
30PDK31.79710062
31PDK41.79710062
32PLK41.77360362
33MINK11.74317455
34PDK21.66280530
35EIF2AK11.64562449
36PINK11.63035741
37IRAK31.60904833
38BCKDK1.57692587
39TYRO31.54118975
40CDK51.46255822
41GRK51.45590523
42RIPK41.43220209
43NME11.42893358
44GRK61.42104913
45STK38L1.39004092
46NEK21.31469266
47NTRK11.29875945
48CDK191.29738522
49PKN11.28059358
50MAPKAPK51.24500711
51PRPF4B1.22772345
52PBK1.15704595
53FGFR21.13193845
54MAP2K21.10974894
55PDK11.10073338
56MET1.09942146
57PRKCI1.09365195
58EIF2AK31.09302811
59PLK11.09192900
60CAMK2A1.08557916
61ZAK1.07924603
62PLK21.07604092
63NME21.04467100
64CASK1.02951868
65BRSK21.02002096
66CAMK10.99243089
67PLK30.98762994
68MAP3K80.96961620
69MAPK130.92904277
70CDK150.91348818
71LATS20.89837753
72CAMK2D0.89239470
73BMPR20.89070046
74AURKA0.88558303
75DYRK30.88394870
76MAPK100.85624047
77CDK180.85310461
78SRPK10.84241001
79CDK11A0.82989126
80CHEK20.82846004
81ARAF0.81323093
82CAMKK20.80953353
83SGK4940.78491833
84SGK2230.78491833
85DAPK10.77637668
86KSR10.77319214
87RAF10.76866408
88TNIK0.76785564
89STK110.76119583
90SGK20.75999973
91MAP3K10.75594106
92PAK10.75401210
93PRKCZ0.74736608
94PRKCG0.74727265
95PAK40.73552312
96ROCK20.73110799
97SGK10.72825395
98MARK20.72458087
99AURKB0.72438126
100CDK140.72014945
101BLK0.71446299
102SGK30.68473270
103STK100.67508841
104BRAF0.67104653
105PRKG10.65803297
106DYRK1A0.64899339
107LMTK20.64439863
108MAP3K120.64336560
109TNK20.63200919
110PRKCH0.62041487
111PHKG10.60997820
112PHKG20.60997820
113MST1R0.60907566
114MAPK120.59981674
115RPS6KA30.59542467
116MKNK10.58520165
117DYRK20.56138877
118BCR0.55184907
119MOS0.54868583
120CSNK1G10.54439092
121MARK10.53866267
122PTK20.53156907
123CDK70.51025166
124WNK10.50881330
125MAP3K110.50336658
126PIM20.50105620
127FYN0.50036839
128MAP3K20.49485262
129PRKCA0.48426146
130PAK30.48367671
131IRAK20.47987185
132PRKD10.47448882
133RPS6KA50.46240185
134CAMK40.45446591
135CSNK1E0.44044596
136CSNK1G30.43546293
137CDK40.43214683
138GSK3A0.41699645
139DMPK0.40975176
140CHEK10.40591858
141STK30.40289095
142DAPK30.39150288
143ABL20.39051731
144ACVR1B0.38745014
145ALK0.37581790
146ERBB20.36601924
147CSNK1A10.36020024
148PIM10.35225438
149SRC0.35167234
150RET0.35102738
151PRKG20.34547030
152PRKACA0.34540872
153BRSK10.34410617
154MELK0.32141182
155PDPK10.31224041
156PRKACG0.30938333
157STK380.30905663
158TLK10.30362038
159VRK10.29598892
160CSNK2A10.29484128
161MAP3K30.29082645
162STK40.28406775
163CDK20.27711023
164CSNK1A1L0.27630556
165CSNK2A20.27388339
166FRK0.27309225
167GRK10.25733982
168CAMK2B0.22711886
169CCNB10.22344092
170RPS6KB20.22299187
171CAMK2G0.22030250
172EIF2AK20.22004384
173SCYL20.21409198
174PRKAA10.21242526
175AKT20.20317213

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049773.65766646
2Vitamin B6 metabolism_Homo sapiens_hsa007503.27718128
3Nicotine addiction_Homo sapiens_hsa050333.01033045
4Synaptic vesicle cycle_Homo sapiens_hsa047212.84627454
5Folate biosynthesis_Homo sapiens_hsa007902.64516047
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.58174578
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.54365813
8Renin-angiotensin system_Homo sapiens_hsa046142.49348316
9Mineral absorption_Homo sapiens_hsa049782.46006492
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45803673
11Long-term potentiation_Homo sapiens_hsa047202.34864011
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.34659418
13Proteasome_Homo sapiens_hsa030502.25460358
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25371928
15Fat digestion and absorption_Homo sapiens_hsa049752.20798986
16GABAergic synapse_Homo sapiens_hsa047272.19385078
17Amphetamine addiction_Homo sapiens_hsa050312.16959225
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14465349
19Glutamatergic synapse_Homo sapiens_hsa047242.10211114
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09568359
21Glutathione metabolism_Homo sapiens_hsa004802.07558067
22Morphine addiction_Homo sapiens_hsa050322.07099442
23Insulin secretion_Homo sapiens_hsa049112.05231323
24Circadian entrainment_Homo sapiens_hsa047132.04717289
25Butanoate metabolism_Homo sapiens_hsa006502.03765829
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02993997
27RNA polymerase_Homo sapiens_hsa030201.99155493
28Fructose and mannose metabolism_Homo sapiens_hsa000511.92646355
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92123966
30Steroid biosynthesis_Homo sapiens_hsa001001.87249931
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78906015
32Gastric acid secretion_Homo sapiens_hsa049711.77312240
33Fatty acid elongation_Homo sapiens_hsa000621.76734678
34Arginine and proline metabolism_Homo sapiens_hsa003301.74676052
35Dopaminergic synapse_Homo sapiens_hsa047281.64539603
36Histidine metabolism_Homo sapiens_hsa003401.64239540
37Cocaine addiction_Homo sapiens_hsa050301.63746192
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57660620
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57481016
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57154931
41Propanoate metabolism_Homo sapiens_hsa006401.50135989
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48883015
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45795531
44Pentose phosphate pathway_Homo sapiens_hsa000301.44778136
45Renin secretion_Homo sapiens_hsa049241.43464192
46Salivary secretion_Homo sapiens_hsa049701.43003959
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42217113
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40610000
49Sphingolipid metabolism_Homo sapiens_hsa006001.38969897
50Regulation of autophagy_Homo sapiens_hsa041401.37679996
51Carbon metabolism_Homo sapiens_hsa012001.35321414
52beta-Alanine metabolism_Homo sapiens_hsa004101.35090171
53Cholinergic synapse_Homo sapiens_hsa047251.34938920
54Long-term depression_Homo sapiens_hsa047301.34871082
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32023980
56Galactose metabolism_Homo sapiens_hsa000521.28884626
57Peroxisome_Homo sapiens_hsa041461.27362003
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27128186
59Gap junction_Homo sapiens_hsa045401.25447763
60Glycerophospholipid metabolism_Homo sapiens_hsa005641.23656186
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.23175341
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21923776
63Sulfur metabolism_Homo sapiens_hsa009201.21125192
64Biosynthesis of amino acids_Homo sapiens_hsa012301.19989408
65Serotonergic synapse_Homo sapiens_hsa047261.17431701
66Pancreatic secretion_Homo sapiens_hsa049721.17066373
67Pyrimidine metabolism_Homo sapiens_hsa002401.15059268
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13599184
69DNA replication_Homo sapiens_hsa030301.11851310
70Starch and sucrose metabolism_Homo sapiens_hsa005001.10733002
71Pyruvate metabolism_Homo sapiens_hsa006201.09377003
72Glycerolipid metabolism_Homo sapiens_hsa005611.08446355
73Protein digestion and absorption_Homo sapiens_hsa049741.07252390
74Taste transduction_Homo sapiens_hsa047421.06489297
75Drug metabolism - other enzymes_Homo sapiens_hsa009831.02514601
76RNA transport_Homo sapiens_hsa030131.01956513
77Olfactory transduction_Homo sapiens_hsa047401.01352912
78Calcium signaling pathway_Homo sapiens_hsa040201.00284381
79Arachidonic acid metabolism_Homo sapiens_hsa005900.99942634
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98348904
81Fatty acid degradation_Homo sapiens_hsa000710.98279566
82cAMP signaling pathway_Homo sapiens_hsa040240.97254945
83Collecting duct acid secretion_Homo sapiens_hsa049660.96643475
84Fatty acid metabolism_Homo sapiens_hsa012120.95679145
85Thyroid hormone synthesis_Homo sapiens_hsa049180.95540036
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95270836
87ABC transporters_Homo sapiens_hsa020100.92021403
88Inositol phosphate metabolism_Homo sapiens_hsa005620.91870761
89Mismatch repair_Homo sapiens_hsa034300.91825288
90Oxytocin signaling pathway_Homo sapiens_hsa049210.91545335
91GnRH signaling pathway_Homo sapiens_hsa049120.91523358
92Estrogen signaling pathway_Homo sapiens_hsa049150.90277672
93Bile secretion_Homo sapiens_hsa049760.89978685
94Tryptophan metabolism_Homo sapiens_hsa003800.88418334
95Metabolic pathways_Homo sapiens_hsa011000.87837006
96Oocyte meiosis_Homo sapiens_hsa041140.85660202
97Ether lipid metabolism_Homo sapiens_hsa005650.85600610
98Selenocompound metabolism_Homo sapiens_hsa004500.85318162
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.83016066
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81903296
101Ovarian steroidogenesis_Homo sapiens_hsa049130.81083306
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80100852
103Purine metabolism_Homo sapiens_hsa002300.79444373
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79413708
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75256326
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74811855
107Other glycan degradation_Homo sapiens_hsa005110.73539487
108PPAR signaling pathway_Homo sapiens_hsa033200.73138323
109Fatty acid biosynthesis_Homo sapiens_hsa000610.71482899
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71257859
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70468039
112Nitrogen metabolism_Homo sapiens_hsa009100.68494041
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67849047
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67801443
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66948100
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66158166
117Linoleic acid metabolism_Homo sapiens_hsa005910.64416128
118Lysosome_Homo sapiens_hsa041420.64360409
119Oxidative phosphorylation_Homo sapiens_hsa001900.63770124
120Nucleotide excision repair_Homo sapiens_hsa034200.63148302
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62998456
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62769393
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.62285280
124Dorso-ventral axis formation_Homo sapiens_hsa043200.62051173
125Circadian rhythm_Homo sapiens_hsa047100.57669890
126Prion diseases_Homo sapiens_hsa050200.57613110
127Arginine biosynthesis_Homo sapiens_hsa002200.57590597
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55798394
129Melanogenesis_Homo sapiens_hsa049160.55684580
130Homologous recombination_Homo sapiens_hsa034400.54645024
131Retinol metabolism_Homo sapiens_hsa008300.53234610
132ErbB signaling pathway_Homo sapiens_hsa040120.52743398
133Base excision repair_Homo sapiens_hsa034100.49201513
134Ribosome_Homo sapiens_hsa030100.48713625
135Caffeine metabolism_Homo sapiens_hsa002320.48398434
136One carbon pool by folate_Homo sapiens_hsa006700.46720445
137Glioma_Homo sapiens_hsa052140.46491424
138Cell cycle_Homo sapiens_hsa041100.46268578
139Tight junction_Homo sapiens_hsa045300.45774569
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.45432600
141Rap1 signaling pathway_Homo sapiens_hsa040150.44711854
142Spliceosome_Homo sapiens_hsa030400.44077926
143Sulfur relay system_Homo sapiens_hsa041220.43695253
144Glucagon signaling pathway_Homo sapiens_hsa049220.43536313
145Choline metabolism in cancer_Homo sapiens_hsa052310.41947231
146Ras signaling pathway_Homo sapiens_hsa040140.41831065
147Phenylalanine metabolism_Homo sapiens_hsa003600.41544021
148Parkinsons disease_Homo sapiens_hsa050120.39739278
149Endocytosis_Homo sapiens_hsa041440.39670084
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.39242957
151Vibrio cholerae infection_Homo sapiens_hsa051100.37662335
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33916231
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.33880313
154Chemical carcinogenesis_Homo sapiens_hsa052040.33754029
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33669708
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33466070
157p53 signaling pathway_Homo sapiens_hsa041150.32253842
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32096913
159Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29066635
160Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28583394
161Huntingtons disease_Homo sapiens_hsa050160.28059817

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