SLC5A12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.97702348
2drug transport (GO:0015893)8.71517626
3regulation of guanylate cyclase activity (GO:0031282)8.17190572
4organic cation transport (GO:0015695)8.12039479
5epoxygenase P450 pathway (GO:0019373)8.03049481
6phosphate ion transport (GO:0006817)7.94185520
7lysine metabolic process (GO:0006553)7.87922970
8lysine catabolic process (GO:0006554)7.87922970
9lipoprotein transport (GO:0042953)7.62233168
10drug catabolic process (GO:0042737)7.48837967
11fat-soluble vitamin biosynthetic process (GO:0042362)7.28510584
12regulation of bile acid biosynthetic process (GO:0070857)6.67750112
13quaternary ammonium group transport (GO:0015697)6.52323890
14exogenous drug catabolic process (GO:0042738)6.50392378
15positive regulation of guanylate cyclase activity (GO:0031284)6.45381359
16phosphate ion transmembrane transport (GO:0035435)6.41068382
17vitamin D metabolic process (GO:0042359)6.09861687
18excretion (GO:0007588)6.01076477
19glyoxylate metabolic process (GO:0046487)5.99391234
20response to mercury ion (GO:0046689)5.91828682
21regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.82625292
22endocrine process (GO:0050886)5.82625292
23regulation of systemic arterial blood pressure by hormone (GO:0001990)5.82625292
24hormone catabolic process (GO:0042447)5.78740891
25phosphate ion homeostasis (GO:0055062)5.67500628
26trivalent inorganic anion homeostasis (GO:0072506)5.67500628
27modified amino acid transport (GO:0072337)5.67434966
28renal absorption (GO:0070293)5.66855946
29tricarboxylic acid metabolic process (GO:0072350)5.57097257
30regulation of triglyceride catabolic process (GO:0010896)5.54403708
31cysteine metabolic process (GO:0006534)5.51024479
32toxin transport (GO:1901998)5.44735923
33homocysteine metabolic process (GO:0050667)5.28368740
34regulation of systemic arterial blood pressure (GO:0003073)5.25759517
35cellular glucuronidation (GO:0052695)5.19598790
36metanephric tubule development (GO:0072170)5.19403974
37metanephric nephron tubule development (GO:0072234)5.19403974
38nonribosomal peptide biosynthetic process (GO:0019184)5.10344692
39aspartate family amino acid catabolic process (GO:0009068)5.10005270
40regulation of cGMP biosynthetic process (GO:0030826)5.06978496
41amino-acid betaine transport (GO:0015838)4.90267878
42carnitine transport (GO:0015879)4.90267878
43short-chain fatty acid metabolic process (GO:0046459)4.89843628
44receptor guanylyl cyclase signaling pathway (GO:0007168)4.87080964
45peptide hormone processing (GO:0016486)4.83969819
46glycoside metabolic process (GO:0016137)4.77745929
47metanephric nephron epithelium development (GO:0072243)4.74870876
48oligosaccharide catabolic process (GO:0009313)4.74154093
49very-low-density lipoprotein particle assembly (GO:0034379)4.71836453
50virion attachment to host cell (GO:0019062)4.70585951
51adhesion of symbiont to host cell (GO:0044650)4.70585951
52bile acid and bile salt transport (GO:0015721)4.65703417
53peptide catabolic process (GO:0043171)4.62256194
54glutathione biosynthetic process (GO:0006750)4.61079047
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.59960765
56digestion (GO:0007586)4.59040845
57diacylglycerol metabolic process (GO:0046339)4.49557333
58alkaloid metabolic process (GO:0009820)4.48859282
59renal system process involved in regulation of blood volume (GO:0001977)4.48818789
60proline metabolic process (GO:0006560)4.45959779
61branched-chain amino acid metabolic process (GO:0009081)4.42008787
62flavonoid metabolic process (GO:0009812)4.39907736
63vitamin transmembrane transport (GO:0035461)4.39526921
64regulation of cGMP metabolic process (GO:0030823)4.35819863
65metanephric epithelium development (GO:0072207)4.35213054
66vitamin A metabolic process (GO:0006776)4.33821179
67fat-soluble vitamin metabolic process (GO:0006775)4.31379530
68plasma lipoprotein particle assembly (GO:0034377)4.28667863
69fructose metabolic process (GO:0006000)4.27049778
70indolalkylamine catabolic process (GO:0046218)4.25793539
71tryptophan catabolic process (GO:0006569)4.25793539
72indole-containing compound catabolic process (GO:0042436)4.25793539
73urea cycle (GO:0000050)4.24146233
74amino-acid betaine metabolic process (GO:0006577)4.19992782
75nephron tubule development (GO:0072080)4.18041872
76aromatic amino acid family catabolic process (GO:0009074)4.18004591
77urea metabolic process (GO:0019627)4.14829311
78NADH metabolic process (GO:0006734)4.14776870
79cellular response to nitric oxide (GO:0071732)4.11230431
80cellular modified amino acid catabolic process (GO:0042219)4.10728659
81regulation of cellular extravasation (GO:0002691)4.10302617
82sulfur compound transport (GO:0072348)4.09325524
83tryptophan metabolic process (GO:0006568)4.08566838
84angiotensin maturation (GO:0002003)4.07702025
85drinking behavior (GO:0042756)4.05520488
86polyol transport (GO:0015791)4.01471529
87L-phenylalanine catabolic process (GO:0006559)3.99922796
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.99922796
89vitamin biosynthetic process (GO:0009110)3.99607731
90L-phenylalanine metabolic process (GO:0006558)3.94510877
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.94510877
92valine metabolic process (GO:0006573)3.93655493
93serine family amino acid catabolic process (GO:0009071)3.90963189
94lipoprotein metabolic process (GO:0042157)3.89918950
95fatty acid beta-oxidation (GO:0006635)3.89476748
96peptide biosynthetic process (GO:0043043)3.88643246
97cGMP biosynthetic process (GO:0006182)3.88102081
98response to parathyroid hormone (GO:0071107)3.88003546
99adhesion of symbiont to host (GO:0044406)3.86750796
100carnitine metabolic process (GO:0009437)3.86157710
101positive regulation of cGMP biosynthetic process (GO:0030828)3.84749972
102serine family amino acid metabolic process (GO:0009069)3.77598735
1032-oxoglutarate metabolic process (GO:0006103)3.77128733
104nitrogen cycle metabolic process (GO:0071941)3.75834841
105cellular response to vitamin D (GO:0071305)3.72593708
106vitamin transport (GO:0051180)3.72262546
107renal tubule development (GO:0061326)3.72214034
108bile acid metabolic process (GO:0008206)3.71359934
109protein-lipid complex assembly (GO:0065005)3.70109205
110response to phenylpropanoid (GO:0080184)3.69991375
111actin filament depolymerization (GO:0030042)3.69699744
112L-ascorbic acid metabolic process (GO:0019852)3.67247845
113glycolipid catabolic process (GO:0019377)3.66284961
114transepithelial transport (GO:0070633)3.64484951
115acetyl-CoA metabolic process (GO:0006084)3.64440692
116drug metabolic process (GO:0017144)3.60118123
117branched-chain amino acid catabolic process (GO:0009083)3.58445814
118glycosphingolipid catabolic process (GO:0046479)3.58030945
119glycerol metabolic process (GO:0006071)3.57965058
120phospholipid efflux (GO:0033700)3.57791390
121positive regulation of glycoprotein biosynthetic process (GO:0010560)3.57469611
122fatty acid oxidation (GO:0019395)3.56460826
123heme transport (GO:0015886)3.56332899
124omega-hydroxylase P450 pathway (GO:0097267)3.54878843
125cellular ketone body metabolic process (GO:0046950)3.52709349
126lipid oxidation (GO:0034440)3.49943787
127arginine metabolic process (GO:0006525)3.49868462
128cellular carbohydrate catabolic process (GO:0044275)3.48271500
129regulation of vitamin metabolic process (GO:0030656)3.47536415
130* sodium ion transport (GO:0006814)3.46349363
131sodium-independent organic anion transport (GO:0043252)3.45628484
132quinone biosynthetic process (GO:1901663)3.45116718
133glycosylceramide metabolic process (GO:0006677)3.44114351
134glutamate metabolic process (GO:0006536)3.43473108
135indole-containing compound metabolic process (GO:0042430)3.43434898
136positive regulation of cGMP metabolic process (GO:0030825)3.40945799
137response to growth hormone (GO:0060416)3.40858790
138nephron epithelium development (GO:0072009)3.39873297
139sulfate transmembrane transport (GO:1902358)3.39563485
140glutamine family amino acid biosynthetic process (GO:0009084)3.36775178
141uronic acid metabolic process (GO:0006063)3.36682876
142glucuronate metabolic process (GO:0019585)3.36682876
143maintenance of gastrointestinal epithelium (GO:0030277)3.33166002
144beta-amyloid metabolic process (GO:0050435)3.32489558
145regulation of cholesterol esterification (GO:0010872)3.31793021
146polyol catabolic process (GO:0046174)3.30729496
147cellular response to reactive nitrogen species (GO:1902170)3.30377927
148response to nitric oxide (GO:0071731)3.29971758
149glomerulus development (GO:0032835)3.29254810
150proline transport (GO:0015824)3.25229960
151fatty acid catabolic process (GO:0009062)3.24585021
152intestinal absorption (GO:0050892)3.24545097
153tricarboxylic acid cycle (GO:0006099)3.24499131
154mRNA modification (GO:0016556)3.24327119
155phenol-containing compound catabolic process (GO:0019336)3.24086874
156bicarbonate transport (GO:0015701)3.23461445
157midgut development (GO:0007494)3.23223558
158glutathione metabolic process (GO:0006749)3.23042643
159response to magnesium ion (GO:0032026)3.22672146
160regulation of protein glycosylation (GO:0060049)3.20984909
161cobalamin metabolic process (GO:0009235)3.20306354
162neurotransmitter biosynthetic process (GO:0042136)3.19944343
163cellular amino acid catabolic process (GO:0009063)3.19446752
164nephron epithelium morphogenesis (GO:0072088)3.19419136
165nephron tubule morphogenesis (GO:0072078)3.19419136
166alditol metabolic process (GO:0019400)3.18510567
167phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.18031484
168sphingomyelin metabolic process (GO:0006684)3.17907234
169auditory receptor cell differentiation (GO:0042491)3.16948296
170sodium ion homeostasis (GO:0055078)3.16633502
171cGMP-mediated signaling (GO:0019934)3.15870665
172renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.14949721
173leukotriene metabolic process (GO:0006691)3.14166687
174aminoglycoside antibiotic metabolic process (GO:0030647)10.7008847
175urate metabolic process (GO:0046415)10.1668308
176drug transmembrane transport (GO:0006855)10.0123181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.59214332
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.97763070
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.34264787
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.17029076
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.12971967
6CDX2_20551321_ChIP-Seq_CACO-2_Human2.83462129
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.69614925
8GATA1_22025678_ChIP-Seq_K562_Human2.64826820
9VDR_22108803_ChIP-Seq_LS180_Human2.57897278
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.52638556
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34941749
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.24658349
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19882028
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.04044311
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.82907022
16GATA4_25053715_ChIP-Seq_YYC3_Human1.82036899
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81909760
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80177895
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76995946
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76793135
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.75467828
22AR_21909140_ChIP-Seq_LNCAP_Human1.74655378
23BCAT_22108803_ChIP-Seq_LS180_Human1.73460479
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.70824800
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70571465
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70339264
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64663410
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62650699
29GBX2_23144817_ChIP-Seq_PC3_Human1.62182026
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59772091
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.57105728
32HNF4A_19822575_ChIP-Seq_HepG2_Human1.53529114
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50317155
34SMAD3_21741376_ChIP-Seq_HESCs_Human1.49794033
35PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.48723216
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48065412
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43184034
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42998098
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40329923
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40316880
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36232828
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.32339697
43FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32152883
44FOXA1_25552417_ChIP-Seq_VCAP_Human1.31974666
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31262078
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.30137242
47GATA6_25053715_ChIP-Seq_YYC3_Human1.27927903
48P300_19829295_ChIP-Seq_ESCs_Human1.27058746
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26809278
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26678304
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23972881
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23020939
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21282382
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.20432465
55* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19992191
56SOX2_20726797_ChIP-Seq_SW620_Human1.19087541
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18988398
58RXR_22108803_ChIP-Seq_LS180_Human1.18656130
59CDX2_22108803_ChIP-Seq_LS180_Human1.18578026
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.16698178
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15474833
62EGR1_19032775_ChIP-ChIP_M12_Human1.14908452
63FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13306283
64NANOG_20526341_ChIP-Seq_ESCs_Human1.12365132
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11862822
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11756401
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11637591
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09648056
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09505478
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.09496896
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08675495
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08139210
73CLOCK_20551151_ChIP-Seq_293T_Human1.07848802
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07520114
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06966142
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04841468
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.04840315
78HNFA_21074721_ChIP-Seq_CACO-2_Human1.04725578
79CEBPB_22108803_ChIP-Seq_LS180_Human1.03405578
80NCOR_22424771_ChIP-Seq_293T_Human1.02898647
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02826954
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02397578
83IGF1R_20145208_ChIP-Seq_DFB_Human1.00990323
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00842238
85IRF1_19129219_ChIP-ChIP_H3396_Human0.99967291
86* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99902986
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99278461
88* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98409907
89* FOXA1_25329375_ChIP-Seq_VCAP_Human0.98409907
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97768150
91* CBP_21632823_ChIP-Seq_H3396_Human0.97694223
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97531511
93ETV1_20927104_ChIP-Seq_GIST48_Human0.97283301
94EP300_21415370_ChIP-Seq_HL-1_Mouse0.97215318
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97010281
96* AR_20517297_ChIP-Seq_VCAP_Human0.96798184
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96569218
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95406110
99MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94455927
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.94293316
101TBL1_22424771_ChIP-Seq_293T_Human0.94123675
102PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93550764
103TP63_23658742_ChIP-Seq_EP156T_Human0.93449549
104* NFYA_21822215_ChIP-Seq_K562_Human0.93129975
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92610931
106STAT1_17558387_ChIP-Seq_HELA_Human0.92406084
107SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92275557
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92226943
109FUS_26573619_Chip-Seq_HEK293_Human0.91132410
110AHR_22903824_ChIP-Seq_MCF-7_Human0.89878174
111STAT3_23295773_ChIP-Seq_U87_Human0.89537454
112NFE2_27457419_Chip-Seq_LIVER_Mouse0.88903373
113CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87585675
114DROSHA_22980978_ChIP-Seq_HELA_Human0.87526647
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87500177
116MYC_19829295_ChIP-Seq_ESCs_Human0.87051853
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87008713
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86436811
119* NANOG_19829295_ChIP-Seq_ESCs_Human0.85444414
120* SOX2_19829295_ChIP-Seq_ESCs_Human0.85444414
121SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84840980
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84390428
123FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83615315
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83538088
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82116757
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81785907
127FLI1_27457419_Chip-Seq_LIVER_Mouse0.80452127
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80450878
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.79846393
130TBX20_22328084_ChIP-Seq_HEART_Mouse0.79846393
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.79152533
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79012400
133KDM2B_26808549_Chip-Seq_REH_Human0.78942285
134MYC_19915707_ChIP-ChIP_AK7_Human0.78888629
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.78646347
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78611815
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78322425
138SMAD4_21799915_ChIP-Seq_A2780_Human0.77435783
139TCF4_22108803_ChIP-Seq_LS180_Human0.77261355
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76229873
141GATA2_19941826_ChIP-Seq_K562_Human0.75581371
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75213175
143VDR_24787735_ChIP-Seq_THP-1_Human0.74830845
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.74671280
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74639711
146ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.74230087
147LXR_22292898_ChIP-Seq_THP-1_Human0.74044223
148RNF2_18974828_ChIP-Seq_MESCs_Mouse0.73065720
149EZH2_18974828_ChIP-Seq_MESCs_Mouse0.73065720
150RACK7_27058665_Chip-Seq_MCF-7_Human0.72697200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.04601596
2MP0004043_abnormal_pH_regulation6.70175104
3MP0004019_abnormal_vitamin_homeostasis5.16404840
4MP0005332_abnormal_amino_acid4.55124891
5MP0002139_abnormal_hepatobiliary_system4.20824904
6MP0003195_calcinosis4.09855503
7MP0001765_abnormal_ion_homeostasis3.73166368
8MP0009643_abnormal_urine_homeostasis3.69422182
9MP0002138_abnormal_hepatobiliary_system3.39942322
10MP0003878_abnormal_ear_physiology3.26228682
11MP0005377_hearing/vestibular/ear_phenot3.26228682
12MP0005636_abnormal_mineral_homeostasis3.00015949
13MP0008875_abnormal_xenobiotic_pharmacok2.98941478
14MP0009379_abnormal_foot_pigmentation2.92070167
15MP0003252_abnormal_bile_duct2.90692659
16MP0002136_abnormal_kidney_physiology2.81371218
17MP0001756_abnormal_urination2.77697334
18MP0001958_emphysema2.47727244
19MP0005365_abnormal_bile_salt2.05754174
20MP0005085_abnormal_gallbladder_physiolo2.04461329
21MP0000538_abnormal_urinary_bladder1.98636335
22MP0010155_abnormal_intestine_physiology1.96573811
23MP0003868_abnormal_feces_composition1.89188557
24MP0001666_abnormal_nutrient_absorption1.88766109
25MP0005409_darkened_coat_color1.79352691
26MP0003718_maternal_effect1.77782861
27MP0005084_abnormal_gallbladder_morpholo1.76139281
28MP0008961_abnormal_basal_metabolism1.71099131
29MP0005451_abnormal_body_composition1.65852010
30MP0001501_abnormal_sleep_pattern1.54663514
31MP0001188_hyperpigmentation1.52451343
32MP0005058_abnormal_lysosome_morphology1.46205101
33MP0005584_abnormal_enzyme/coenzyme_acti1.42972619
34MP0004147_increased_porphyrin_level1.42146974
35MP0004264_abnormal_extraembryonic_tissu1.39430544
36MP0003283_abnormal_digestive_organ1.39229712
37MP0002822_catalepsy1.38437623
38MP0004885_abnormal_endolymph1.34734869
39MP0002876_abnormal_thyroid_physiology1.34593102
40MP0003300_gastrointestinal_ulcer1.33866931
41MP0003186_abnormal_redox_activity1.28833396
42MP0004270_analgesia1.28169880
43MP0000490_abnormal_crypts_of1.23083275
44MP0000230_abnormal_systemic_arterial1.20813160
45MP0005319_abnormal_enzyme/_coenzyme1.15112436
46MP0002168_other_aberrant_phenotype1.11507351
47MP0002928_abnormal_bile_duct1.10772800
48MP0000477_abnormal_intestine_morphology1.06612481
49MP0003183_abnormal_peptide_metabolism1.02955911
50MP0001764_abnormal_homeostasis1.02176732
51MP0005448_abnormal_energy_balance1.01150463
52MP0010352_gastrointestinal_tract_polyps1.00296919
53MP0002135_abnormal_kidney_morphology1.00245799
54MP0010329_abnormal_lipoprotein_level0.96556379
55MP0002089_abnormal_postnatal_growth/wei0.95073433
56MP0005535_abnormal_body_temperature0.91878241
57MP0006036_abnormal_mitochondrial_physio0.91129842
58MP0009780_abnormal_chondrocyte_physiolo0.90641381
59MP0010234_abnormal_vibrissa_follicle0.89970218
60MP0002971_abnormal_brown_adipose0.88919294
61MP0002896_abnormal_bone_mineralization0.84008924
62MP0002118_abnormal_lipid_homeostasis0.83035079
63MP0005174_abnormal_tail_pigmentation0.80425608
64MP0003638_abnormal_response/metabolism_0.79970828
65MP0009764_decreased_sensitivity_to0.79634962
66MP0003646_muscle_fatigue0.78240604
67MP0005670_abnormal_white_adipose0.77378606
68MP0009642_abnormal_blood_homeostasis0.73598700
69MP0005395_other_phenotype0.72141571
70MP0009115_abnormal_fat_cell0.71046697
71MP0001664_abnormal_digestion0.70785255
72MP0005666_abnormal_adipose_tissue0.69969522
73MP0010386_abnormal_urinary_bladder0.69649448
74MP0001873_stomach_inflammation0.68738689
75MP0002396_abnormal_hematopoietic_system0.67010135
76MP0003806_abnormal_nucleotide_metabolis0.65811363
77MP0001663_abnormal_digestive_system0.65423667
78MP0003879_abnormal_hair_cell0.64291583
79MP0003191_abnormal_cellular_cholesterol0.63310316
80MP0000678_abnormal_parathyroid_gland0.63087804
81MP0005367_renal/urinary_system_phenotyp0.63001258
82MP0000516_abnormal_urinary_system0.63001258
83MP0000427_abnormal_hair_cycle0.61550605
84MP0004782_abnormal_surfactant_physiolog0.57677524
85MP0005220_abnormal_exocrine_pancreas0.56042956
86MP0005381_digestive/alimentary_phenotyp0.55695247
87MP0000537_abnormal_urethra_morphology0.54673774
88MP0003866_abnormal_defecation0.53053656
89MP0000609_abnormal_liver_physiology0.51986951
90MP0004742_abnormal_vestibular_system0.49697771
91MP0002098_abnormal_vibrissa_morphology0.49549361
92MP0003172_abnormal_lysosome_physiology0.49257854
93MP0000015_abnormal_ear_pigmentation0.49215661
94MP0002796_impaired_skin_barrier0.49102266
95MP0009697_abnormal_copulation0.48590745
96MP0003953_abnormal_hormone_level0.48328475
97MP0000371_diluted_coat_color0.48025264
98MP0002069_abnormal_eating/drinking_beha0.47828264
99MP0005334_abnormal_fat_pad0.47690426
100MP0008469_abnormal_protein_level0.46425771
101MP0002078_abnormal_glucose_homeostasis0.46235728
102MP0001845_abnormal_inflammatory_respons0.45797710
103MP0001485_abnormal_pinna_reflex0.44934230
104MP0004484_altered_response_of0.44446275
105MP0002115_abnormal_skeleton_extremities0.44405135
106MP0002998_abnormal_bone_remodeling0.41712444
107MP0006138_congestive_heart_failure0.41696693
108MP0005376_homeostasis/metabolism_phenot0.40976118
109MP0004215_abnormal_myocardial_fiber0.40873364
110MP0003959_abnormal_lean_body0.40867534
111MP0005501_abnormal_skin_physiology0.40698690
112MP0008775_abnormal_heart_ventricle0.39912006
113MP0005165_increased_susceptibility_to0.39719222
114MP0001963_abnormal_hearing_physiology0.39534885
115MP0001177_atelectasis0.38710200
116MP0000534_abnormal_ureter_morphology0.38515019
117MP0003795_abnormal_bone_structure0.38389150
118MP0005551_abnormal_eye_electrophysiolog0.37494785
119MP0000249_abnormal_blood_vessel0.37417805
120MP0000163_abnormal_cartilage_morphology0.35178550
121MP0000598_abnormal_liver_morphology0.34901323
122MP0005408_hypopigmentation0.34813705
123MP0009840_abnormal_foam_cell0.34614535
124MP0004085_abnormal_heartbeat0.34406577
125MP0005167_abnormal_blood-brain_barrier0.34021949
126MP0002638_abnormal_pupillary_reflex0.33686393
127MP0004858_abnormal_nervous_system0.32938552
128MP0001440_abnormal_grooming_behavior0.31999459
129MP0008872_abnormal_physiological_respon0.30690588
130MP0000462_abnormal_digestive_system0.30475919
131MP0000747_muscle_weakness0.29563301
132MP0005166_decreased_susceptibility_to0.29004934
133MP0002909_abnormal_adrenal_gland0.27820901
134MP0000566_synostosis0.27423061
135MP0005410_abnormal_fertilization0.26574343
136MP0001661_extended_life_span0.25979724
137MP0005310_abnormal_salivary_gland0.25881765
138MP0001731_abnormal_postnatal_growth0.25678988
139MP0000026_abnormal_inner_ear0.25537199

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)8.25305664
2Metabolic alkalosis (HP:0200114)7.26678446
3Hypokalemic alkalosis (HP:0001949)7.25427279
4Hyperactive renin-angiotensin system (HP:0000841)7.12259695
5Hypomagnesemia (HP:0002917)6.93672595
6Polyuria (HP:0000103)6.67426569
7Gout (HP:0001997)6.55378125
8Abnormal urine output (HP:0012590)6.44683550
9Abnormality of chloride homeostasis (HP:0011422)6.33009673
10Abnormality of renal excretion (HP:0011036)6.13166586
11Abnormality of magnesium homeostasis (HP:0004921)5.93197610
12Hypobetalipoproteinemia (HP:0003563)5.72266364
13Abnormality of glutamine family amino acid metabolism (HP:0010902)5.55595951
14Proximal tubulopathy (HP:0000114)5.53700035
15Abnormal drinking behavior (HP:0030082)5.34267219
16Polydipsia (HP:0001959)5.34267219
17Tetany (HP:0001281)4.99728872
18Abnormality of renin-angiotensin system (HP:0000847)4.93947988
19Chronic diarrhea (HP:0002028)4.91742857
20Hyperglycinuria (HP:0003108)4.91295278
21Hyperaldosteronism (HP:0000859)4.75656739
22Alkalosis (HP:0001948)4.75585072
23Increased purine levels (HP:0004368)4.65594931
24Hyperuricemia (HP:0002149)4.65594931
25Renal salt wasting (HP:0000127)4.56848762
26Acanthocytosis (HP:0001927)4.56415134
27Ileus (HP:0002595)4.40692119
28Abnormality of purine metabolism (HP:0004352)4.35036428
29Fat malabsorption (HP:0002630)4.28768789
30Hypercalciuria (HP:0002150)4.17983996
31Abnormality of vitamin metabolism (HP:0100508)4.12889593
32Generalized aminoaciduria (HP:0002909)4.06987981
33Pigmentary retinal degeneration (HP:0001146)4.05917961
34Glycosuria (HP:0003076)3.98020414
35Abnormality of urine glucose concentration (HP:0011016)3.98020414
36Hydroxyprolinuria (HP:0003080)3.97770560
37Abnormality of proline metabolism (HP:0010907)3.97770560
38Abnormality of glycine metabolism (HP:0010895)3.87215353
39Abnormality of serine family amino acid metabolism (HP:0010894)3.87215353
40Hypokalemia (HP:0002900)3.78911101
41Renal tubular acidosis (HP:0001947)3.59752809
42Widely patent fontanelles and sutures (HP:0004492)3.37170036
43Ketoacidosis (HP:0001993)3.37069845
44Megaloblastic anemia (HP:0001889)3.34509158
45Hyperphosphaturia (HP:0003109)3.33600738
46Abnormality of nucleobase metabolism (HP:0010932)3.30964700
47Abnormal urine phosphate concentration (HP:0012599)3.25285098
48Congenital sensorineural hearing impairment (HP:0008527)3.24043452
49Delayed epiphyseal ossification (HP:0002663)3.22696333
50Abnormality of potassium homeostasis (HP:0011042)3.19532667
51Nephrolithiasis (HP:0000787)3.01761448
52Nephrocalcinosis (HP:0000121)2.97124372
53Posterior subcapsular cataract (HP:0007787)2.85354440
54Hypophosphatemia (HP:0002148)2.85283770
55Ketosis (HP:0001946)2.84985527
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.81817811
57Dehydration (HP:0001944)2.81261222
58Xanthomatosis (HP:0000991)2.79516815
59Steatorrhea (HP:0002570)2.78310183
60Hypolipoproteinemia (HP:0010981)2.70702550
61Malnutrition (HP:0004395)2.66660275
62Facial shape deformation (HP:0011334)2.61378209
63Potter facies (HP:0002009)2.61378209
64Abdominal distention (HP:0003270)2.57923658
65Rickets (HP:0002748)2.57605698
66Abnormality of fatty-acid metabolism (HP:0004359)2.56557696
67Chorioretinal atrophy (HP:0000533)2.50716633
68Vascular calcification (HP:0004934)2.48239697
69Epidermoid cyst (HP:0200040)2.45036852
70Focal segmental glomerulosclerosis (HP:0000097)2.39090982
71Confusion (HP:0001289)2.36743775
72Renal tubular dysfunction (HP:0000124)2.35305007
73Thin bony cortex (HP:0002753)2.31917278
74Bilateral sensorineural hearing impairment (HP:0008619)2.30315871
75Metaphyseal cupping (HP:0003021)2.29739244
76Abnormality of sodium homeostasis (HP:0010931)2.29429312
77Abnormality of renal resorption (HP:0011038)2.28778359
78Hyponatremia (HP:0002902)2.27705583
79Enlarged kidneys (HP:0000105)2.26811972
80Hyperglycinemia (HP:0002154)2.24735126
81Metabolic acidosis (HP:0001942)2.23718890
82Abnormality of the costochondral junction (HP:0000919)2.23243011
83Hyperammonemia (HP:0001987)2.20676118
84Delayed CNS myelination (HP:0002188)2.20178432
85Vacuolated lymphocytes (HP:0001922)2.19850253
86Cardiovascular calcification (HP:0011915)2.18352749
87Vomiting (HP:0002013)2.11857783
88Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11753742
89Systemic lupus erythematosus (HP:0002725)2.11457917
90Adrenal overactivity (HP:0002717)2.10534860
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10491355
92Poikilocytosis (HP:0004447)2.10031300
93Abnormality of sulfur amino acid metabolism (HP:0004339)2.07327746
94Abnormal glucose tolerance (HP:0001952)2.06376577
95Abnormal enzyme/coenzyme activity (HP:0012379)2.06348134
96Abnormality of alkaline phosphatase activity (HP:0004379)2.01944168
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01101809
98Dicarboxylic aciduria (HP:0003215)2.01101809
99Metaphyseal irregularity (HP:0003025)1.96078334
100Tubular atrophy (HP:0000092)1.95058864
101Chondrocalcinosis (HP:0000934)1.94967897
102Hypoalbuminemia (HP:0003073)1.93519029
103Abnormal albumin level (HP:0012116)1.93519029
104Hyperventilation (HP:0002883)1.91738803
105Tubulointerstitial fibrosis (HP:0005576)1.91338253
106Subcapsular cataract (HP:0000523)1.91029007
107Wide cranial sutures (HP:0010537)1.89821320
108Protuberant abdomen (HP:0001538)1.88389975
109Abnormality of Sharpey fibers (HP:0100685)1.86702207
110Hypotension (HP:0002615)1.85014003
111Polyphagia (HP:0002591)1.82923115
112Bicornuate uterus (HP:0000813)1.81673850
113Methylmalonic aciduria (HP:0012120)1.81528981
114Nausea (HP:0002018)1.81385102
115Lethargy (HP:0001254)1.80896732
116Villous atrophy (HP:0011473)1.80479076
117Abnormality of small intestinal villus morphology (HP:0011472)1.80479076
118Cerebral palsy (HP:0100021)1.79058806
119Abnormality of the vitamin B12 metabolism (HP:0004341)1.78905750
120Enlarged epiphyses (HP:0010580)1.78322666
121Abnormal eating behavior (HP:0100738)1.77585270
122Abnormal tarsal ossification (HP:0008369)1.76644021
123Hyperparathyroidism (HP:0000843)1.75925363
124Glomerulosclerosis (HP:0000096)1.75372209
125Decreased circulating renin level (HP:0003351)1.67330747
126Abnormality of vitamin B metabolism (HP:0004340)1.65778073
127Elevated alkaline phosphatase (HP:0003155)1.64529596
128Irritability (HP:0000737)1.63501583
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.60847878
130Hypophosphatemic rickets (HP:0004912)1.58897260
131Generalized muscle weakness (HP:0003324)1.57897336
132Sensorimotor neuropathy (HP:0007141)1.56044923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.10138662
2SRC9.07726060
3WNK48.76026211
4WNK38.63639170
5OXSR17.89541739
6STK394.32233322
7STK38L2.44162015
8TNIK2.16225181
9BCKDK2.06216452
10SGK2231.88900506
11SGK4941.88900506
12MST41.88313753
13WNK11.70889807
14EPHA21.65388977
15PDK31.62986468
16PDK41.62986468
17MST1R1.60830213
18MAP3K121.44363812
19NEK11.31987632
20ADRBK21.22623328
21SGK21.22415847
22PDK21.18589208
23STK381.15754362
24SGK31.07701989
25GRK61.05518606
26FRK1.05362762
27DDR21.00297518
28ERBB20.98140685
29EPHA30.92111378
30NLK0.90573057
31INSRR0.87272010
32MATK0.84670903
33BRSK20.84488231
34PIK3CA0.83823323
35STK240.71780407
36TESK20.71347799
37FGFR40.71136687
38MAP3K70.70961952
39MAP2K20.70381740
40BMPR1B0.62840612
41MAP4K20.62132920
42SGK10.61397144
43GSK3A0.60439677
44STK30.60303548
45PINK10.58385984
46AKT30.57636645
47PRKAA10.57151199
48EPHB10.54173584
49DAPK20.53044707
50PRKAA20.52680392
51LRRK20.51730001
52TEC0.51601649
53LATS10.51297409
54TYK20.50914368
55MAP3K20.50107192
56ERBB40.49788158
57PTK20.48907040
58MAP3K140.46777177
59PRKCI0.44839393
60MAP2K60.43611889
61NME10.43530293
62NEK20.43417276
63MAPK110.43299879
64CAMK2D0.42408125
65MAP3K30.42141094
66CDK190.41621001
67PLK40.41593024
68PTK60.40891668
69PDPK10.40091597
70BCR0.39938926
71TIE10.38953637
72DYRK1B0.38289748
73NEK60.36533904
74CAMK2A0.34696758
75STK100.33662082
76MET0.32898687
77IRAK30.32783791
78PRKD20.31504619
79CASK0.31270627
80BMPR20.30867750
81ERN10.30221199
82FER0.29444684
83PRKCZ0.29333665
84PAK40.28629902
85ERBB30.27696485
86PAK30.26999734
87PRKG20.26081346
88MAP4K10.25640442
89MAP3K10.25510181
90LMTK20.25067347
91PDK10.25054418
92PRKCB0.24346682
93PRKG10.23753014
94YES10.22683383
95ABL20.22619595
96MYLK0.21215925
97PRKCD0.20903431
98CAMK2B0.20703935
99STK110.20651417
100MUSK0.20288434
101MAP3K60.20159898
102MAPK150.18902797
103PRKACG0.18627982
104NTRK30.18203494
105AKT20.17998743
106TTK0.17623514
107RIPK10.16933146
108PRKCA0.16679471
109BMX0.15147512
110PRKACA0.14247969
111EPHA40.12716067
112PRKCH0.11326914
113MAP2K40.09861197
114TGFBR20.09527458
115SIK30.09490215
116EPHB20.08800518
117PTK2B0.07573044
118PIM10.07067860
119PRKCE0.06801154
120ROCK10.06672644
121NUAK10.06015566
122GRK10.05266977
123MAP3K130.05098167
124MELK0.05051054
125FGFR30.02932289
126INSR0.02900645
127PIK3CG0.02755138
128NTRK10.02625846
129CSNK1A10.02475584
130ITK0.02120496
131PRKCQ0.02013083
132PRKCG0.01562913
133MAP3K100.01461201
134IGF1R0.00914816
135IRAK10.00865143
136MAP3K90.00753108
137JAK20.00715144
138CSK0.00223328
139ADRBK10.00050895

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.66454360
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44771170
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.38475404
4Butanoate metabolism_Homo sapiens_hsa006503.34400860
5Vitamin digestion and absorption_Homo sapiens_hsa049773.06599584
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.95216511
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91392388
8Propanoate metabolism_Homo sapiens_hsa006402.84813990
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76358872
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72368841
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47935066
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47071828
13Collecting duct acid secretion_Homo sapiens_hsa049662.41393530
14Linoleic acid metabolism_Homo sapiens_hsa005912.26716085
15Peroxisome_Homo sapiens_hsa041462.21794637
16Pyruvate metabolism_Homo sapiens_hsa006202.21587000
17Tryptophan metabolism_Homo sapiens_hsa003802.20260752
18Fatty acid degradation_Homo sapiens_hsa000712.15566412
19Mineral absorption_Homo sapiens_hsa049782.10988450
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97151978
21Renin-angiotensin system_Homo sapiens_hsa046141.88975408
22beta-Alanine metabolism_Homo sapiens_hsa004101.86276346
23Protein digestion and absorption_Homo sapiens_hsa049741.82660530
24Starch and sucrose metabolism_Homo sapiens_hsa005001.78813326
25Bile secretion_Homo sapiens_hsa049761.74331131
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67083003
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61459898
28Sulfur metabolism_Homo sapiens_hsa009201.60851977
29Glutathione metabolism_Homo sapiens_hsa004801.52613226
30Fatty acid metabolism_Homo sapiens_hsa012121.51524368
31Carbon metabolism_Homo sapiens_hsa012001.49348994
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45952717
33Arginine and proline metabolism_Homo sapiens_hsa003301.45672228
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36257646
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35387453
36Lysine degradation_Homo sapiens_hsa003101.28726387
37PPAR signaling pathway_Homo sapiens_hsa033201.28015638
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25322036
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19620865
40Other glycan degradation_Homo sapiens_hsa005111.18697404
41Folate biosynthesis_Homo sapiens_hsa007901.18223648
42Ether lipid metabolism_Homo sapiens_hsa005651.14691470
43Histidine metabolism_Homo sapiens_hsa003401.13304586
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13296549
45Arginine biosynthesis_Homo sapiens_hsa002201.11058397
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07097604
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.06725666
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05844033
49Fat digestion and absorption_Homo sapiens_hsa049750.99928591
50Glycerolipid metabolism_Homo sapiens_hsa005610.99901341
51Fructose and mannose metabolism_Homo sapiens_hsa000510.99509318
52Phenylalanine metabolism_Homo sapiens_hsa003600.90849206
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87807456
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.80391772
55Biosynthesis of amino acids_Homo sapiens_hsa012300.78803562
56Galactose metabolism_Homo sapiens_hsa000520.77567111
57Selenocompound metabolism_Homo sapiens_hsa004500.65648770
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.63168642
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.62670836
60Asthma_Homo sapiens_hsa053100.61518959
61Nitrogen metabolism_Homo sapiens_hsa009100.60504242
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.60364061
63Sphingolipid metabolism_Homo sapiens_hsa006000.58004207
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.57287505
65Retinol metabolism_Homo sapiens_hsa008300.55097780
66Thyroid hormone synthesis_Homo sapiens_hsa049180.54406098
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53229572
68ABC transporters_Homo sapiens_hsa020100.52021159
69Chemical carcinogenesis_Homo sapiens_hsa052040.51738676
70Metabolic pathways_Homo sapiens_hsa011000.51629956
71Fatty acid elongation_Homo sapiens_hsa000620.51621802
72Gastric acid secretion_Homo sapiens_hsa049710.50553442
73Pentose phosphate pathway_Homo sapiens_hsa000300.47983847
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47900052
75Oxidative phosphorylation_Homo sapiens_hsa001900.45782399
76Lysosome_Homo sapiens_hsa041420.45624628
77Fatty acid biosynthesis_Homo sapiens_hsa000610.43411878
78Vibrio cholerae infection_Homo sapiens_hsa051100.40067770
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.38400519
80Synaptic vesicle cycle_Homo sapiens_hsa047210.36745072
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.36370887
82Renin secretion_Homo sapiens_hsa049240.36264487
83Cocaine addiction_Homo sapiens_hsa050300.36100198
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34838405
85Serotonergic synapse_Homo sapiens_hsa047260.33681746
86Arachidonic acid metabolism_Homo sapiens_hsa005900.33227905
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32057457
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29351928
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29016579
90Insulin secretion_Homo sapiens_hsa049110.27266415
91Steroid biosynthesis_Homo sapiens_hsa001000.27247573
92Allograft rejection_Homo sapiens_hsa053300.26497245
93Caffeine metabolism_Homo sapiens_hsa002320.26368433
94Glucagon signaling pathway_Homo sapiens_hsa049220.25105619
95Sulfur relay system_Homo sapiens_hsa041220.24575409
96Choline metabolism in cancer_Homo sapiens_hsa052310.23466796
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23229612
98Autoimmune thyroid disease_Homo sapiens_hsa053200.22911634
99Graft-versus-host disease_Homo sapiens_hsa053320.21775024
100Inositol phosphate metabolism_Homo sapiens_hsa005620.19290290
101Ovarian steroidogenesis_Homo sapiens_hsa049130.15936715
102Amphetamine addiction_Homo sapiens_hsa050310.15589149
103Rheumatoid arthritis_Homo sapiens_hsa053230.13745542
104Tyrosine metabolism_Homo sapiens_hsa003500.10864501
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10251873
106Type I diabetes mellitus_Homo sapiens_hsa049400.09771319
107Parkinsons disease_Homo sapiens_hsa050120.06029443
108Bladder cancer_Homo sapiens_hsa052190.05923189
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.04284960
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.03922369
111Insulin resistance_Homo sapiens_hsa049310.03167858
112Tight junction_Homo sapiens_hsa045300.02893494
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.02320664
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.01896425
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.01290768
116Cardiac muscle contraction_Homo sapiens_hsa04260-0.0911654
117Phagosome_Homo sapiens_hsa04145-0.0796911
118Pancreatic secretion_Homo sapiens_hsa04972-0.0674862
119Alzheimers disease_Homo sapiens_hsa05010-0.0672392
120Cholinergic synapse_Homo sapiens_hsa04725-0.0668222
121Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0645546
122Dopaminergic synapse_Homo sapiens_hsa04728-0.0459775
123Hepatitis C_Homo sapiens_hsa05160-0.0390580
124AMPK signaling pathway_Homo sapiens_hsa04152-0.0381232
125Staphylococcus aureus infection_Homo sapiens_hsa05150-0.0080855

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