SLC5A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to dietary excess (GO:0002021)7.45541415
2sexual reproduction (GO:0019953)6.57148514
3proline transport (GO:0015824)5.39093361
4pigment cell differentiation (GO:0050931)5.31578522
5melanocyte differentiation (GO:0030318)5.27980872
6developmental pigmentation (GO:0048066)4.96192718
7phenol-containing compound biosynthetic process (GO:0046189)4.93225762
8L-serine transport (GO:0015825)4.41126564
9cellular response to nitric oxide (GO:0071732)4.36047828
10secondary metabolic process (GO:0019748)4.24864880
11angiotensin maturation (GO:0002003)4.18805179
12pigment biosynthetic process (GO:0046148)4.00486691
13cellular response to reactive nitrogen species (GO:1902170)3.85345821
14sequestering of extracellular ligand from receptor (GO:0035581)3.82540546
15fat-soluble vitamin biosynthetic process (GO:0042362)3.73449476
16neuroepithelial cell differentiation (GO:0060563)3.71945863
17tyrosine metabolic process (GO:0006570)3.69896320
18phospholipid scrambling (GO:0017121)3.68794590
19serine transport (GO:0032329)3.59036070
20melanosome organization (GO:0032438)3.57970963
21fructose metabolic process (GO:0006000)3.57807095
22signal peptide processing (GO:0006465)3.57138062
23pigment metabolic process (GO:0042440)3.44121066
24glycosylceramide metabolic process (GO:0006677)3.42870622
25regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.41887179
26NADH metabolic process (GO:0006734)3.38313945
27regulation of integrin-mediated signaling pathway (GO:2001044)3.37939224
28alanine transport (GO:0032328)3.36715110
29pigment granule organization (GO:0048753)3.29845021
30negative regulation of activin receptor signaling pathway (GO:0032926)3.27162016
31pigmentation (GO:0043473)3.23715272
32neutral amino acid transport (GO:0015804)3.19649173
33piRNA metabolic process (GO:0034587)3.18130047
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13892874
35cullin deneddylation (GO:0010388)3.12518121
36lipoprotein transport (GO:0042953)3.10011207
37virion attachment to host cell (GO:0019062)3.02846408
38adhesion of symbiont to host cell (GO:0044650)3.02846408
39endosome to pigment granule transport (GO:0043485)2.98710422
40endosome to melanosome transport (GO:0035646)2.98710422
41ketone body metabolic process (GO:1902224)2.97321226
42glutathione derivative metabolic process (GO:1901685)2.92592557
43glutathione derivative biosynthetic process (GO:1901687)2.92592557
44glycosphingolipid catabolic process (GO:0046479)2.92464699
45flavonoid metabolic process (GO:0009812)2.92450643
46very-low-density lipoprotein particle assembly (GO:0034379)2.92352976
47regulation of bile acid biosynthetic process (GO:0070857)2.91176858
48sialylation (GO:0097503)2.88676690
49response to nitric oxide (GO:0071731)2.87890612
50inositol phosphate catabolic process (GO:0071545)2.86103763
51phosphorylated carbohydrate dephosphorylation (GO:0046838)2.83517177
52inositol phosphate dephosphorylation (GO:0046855)2.83517177
53glycolipid catabolic process (GO:0019377)2.80587616
54regulation of mesoderm development (GO:2000380)2.79205522
55adhesion of symbiont to host (GO:0044406)2.75925560
56gluconeogenesis (GO:0006094)2.71335904
57centrosome duplication (GO:0051298)2.69060045
58ceramide catabolic process (GO:0046514)2.63777127
59transepithelial transport (GO:0070633)2.63478723
60polyol catabolic process (GO:0046174)2.62566440
61heme transport (GO:0015886)2.62159889
62regulation of Golgi to plasma membrane protein transport (GO:0042996)2.60833118
63midgut development (GO:0007494)2.58967299
64negative regulation of receptor-mediated endocytosis (GO:0048261)2.58408699
65oxaloacetate metabolic process (GO:0006107)2.54331777
66anterior/posterior axis specification, embryo (GO:0008595)2.54192504
67mRNA modification (GO:0016556)2.53973260
68establishment of melanosome localization (GO:0032401)2.53610545
69vitamin catabolic process (GO:0009111)2.50914828
70fat-soluble vitamin catabolic process (GO:0042363)2.50914828
71epoxygenase P450 pathway (GO:0019373)2.50586794
72positive regulation of glycoprotein metabolic process (GO:1903020)2.49830251
73regulation of guanylate cyclase activity (GO:0031282)2.48476560
74anterior/posterior axis specification (GO:0009948)2.47406996
75columnar/cuboidal epithelial cell differentiation (GO:0002065)2.45974760
76insulin secretion (GO:0030073)2.45888413
77negative regulation of JUN kinase activity (GO:0043508)2.44625014
78L-ascorbic acid metabolic process (GO:0019852)2.44371954
79protein deneddylation (GO:0000338)2.43702915
80melanosome localization (GO:0032400)2.42891281
81melanosome transport (GO:0032402)2.42507214
82positive regulation of protein autophosphorylation (GO:0031954)2.42255600
83hexose biosynthetic process (GO:0019319)2.41462643
84positive regulation of glycoprotein biosynthetic process (GO:0010560)2.38691761
85regulation of superoxide anion generation (GO:0032928)2.36429191
86negative regulation of neurological system process (GO:0031645)2.36421700
87establishment of pigment granule localization (GO:0051905)2.35010037
88positive regulation of DNA-dependent DNA replication (GO:2000105)2.33444769
89regulation of early endosome to late endosome transport (GO:2000641)2.31789626
90zinc ion transport (GO:0006829)2.29912294
91cell migration involved in gastrulation (GO:0042074)2.29198678
92negative regulation of axon extension involved in axon guidance (GO:0048843)2.28875428
93digestion (GO:0007586)2.28045866
94intestinal absorption (GO:0050892)2.26965153
95pigment granule localization (GO:0051875)2.26207585
96glycine transport (GO:0015816)2.25302516
97cellular response to superoxide (GO:0071451)2.24250601
98melanin biosynthetic process (GO:0042438)13.7825832
99melanin metabolic process (GO:0006582)12.4167015
100secondary metabolite biosynthetic process (GO:0044550)11.9805151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.29686284
2POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82254506
3PIAS1_25552417_ChIP-Seq_VCAP_Human2.70249932
4SMAD3_21741376_ChIP-Seq_EPCs_Human2.67114520
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.66106787
6AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.61822472
7P300_19829295_ChIP-Seq_ESCs_Human2.50044206
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47777209
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.36270518
10SMAD3_21741376_ChIP-Seq_HESCs_Human2.24318149
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21016742
12GATA1_22025678_ChIP-Seq_K562_Human2.11866556
13FUS_26573619_Chip-Seq_HEK293_Human2.10828790
14SMAD4_21741376_ChIP-Seq_HESCs_Human2.09905218
15SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.07953312
16AR_21909140_ChIP-Seq_LNCAP_Human2.05978909
17CDX2_20551321_ChIP-Seq_CACO-2_Human1.87038544
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81893578
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76415719
20OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75658756
21BCAT_22108803_ChIP-Seq_LS180_Human1.75081838
22* AR_25329375_ChIP-Seq_VCAP_Human1.74644390
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69579688
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67115104
25NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64982415
26TCF4_22108803_ChIP-Seq_LS180_Human1.64593809
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64017748
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60586611
29AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.58841391
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55613347
31SMAD4_21799915_ChIP-Seq_A2780_Human1.54728937
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52126004
33JUN_21703547_ChIP-Seq_K562_Human1.50616697
34GATA4_25053715_ChIP-Seq_YYC3_Human1.48411986
35RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48112962
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.47755185
37CDX2_22108803_ChIP-Seq_LS180_Human1.44850328
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.44613019
39ZNF274_21170338_ChIP-Seq_K562_Hela1.43602972
40STAT3_23295773_ChIP-Seq_U87_Human1.42485795
41TAF15_26573619_Chip-Seq_HEK293_Human1.40268258
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.35358150
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.34726397
44CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32248420
45FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31157943
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29948600
47* TCF4_23295773_ChIP-Seq_U87_Human1.29513034
48CBP_20019798_ChIP-Seq_JUKART_Human1.28959662
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28959662
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28777236
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28101159
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26755771
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25589799
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25348234
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24241998
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24241998
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.23712243
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23590238
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23526595
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22710992
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22276561
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.20844734
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19636565
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19079183
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.18784071
66ER_23166858_ChIP-Seq_MCF-7_Human1.18479974
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17922850
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17896445
69EWS_26573619_Chip-Seq_HEK293_Human1.15903277
70* SMAD3_21741376_ChIP-Seq_ESCs_Human1.15424933
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15363922
72KDM2B_26808549_Chip-Seq_REH_Human1.14454689
73GBX2_23144817_ChIP-Seq_PC3_Human1.13935451
74E2F7_22180533_ChIP-Seq_HELA_Human1.13502431
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.11097070
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11055907
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10645771
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10119219
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.09912396
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09737989
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07850019
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07505898
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06729872
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06718095
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06149544
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04724271
87EOMES_21245162_ChIP-Seq_HESCs_Human1.04370429
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.03397214
89FOXA1_25552417_ChIP-Seq_VCAP_Human1.01864504
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01057769
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00103435
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99813228
93* MITF_21258399_ChIP-Seq_MELANOMA_Human0.99747816
94RUNX2_22187159_ChIP-Seq_PCA_Human0.98283821
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.98026155
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97888272
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.96838629
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96629670
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.96292951
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95478558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation8.05458630
2MP0005171_absent_coat_pigmentation6.82335851
3MP0003136_yellow_coat_color5.84350586
4MP0005408_hypopigmentation5.17934936
5MP0005075_abnormal_melanosome_morpholog3.86577573
6MP0000015_abnormal_ear_pigmentation3.82017350
7MP0005257_abnormal_intraocular_pressure3.78584500
8MP0004381_abnormal_hair_follicle2.78406906
9MP0002822_catalepsy2.74712097
10MP0002095_abnormal_skin_pigmentation2.72164153
11MP0002938_white_spotting2.70813725
12MP0000371_diluted_coat_color2.58820182
13MP0005409_darkened_coat_color2.35281995
14MP0002877_abnormal_melanocyte_morpholog2.28744592
15MP0005360_urolithiasis2.23789245
16MP0004147_increased_porphyrin_level2.10662165
17MP0003806_abnormal_nucleotide_metabolis2.08107159
18MP0005174_abnormal_tail_pigmentation2.06941630
19MP0008961_abnormal_basal_metabolism2.05071658
20MP0001324_abnormal_eye_pigmentation1.97964488
21MP0003890_abnormal_embryonic-extraembry1.95083315
22MP0002638_abnormal_pupillary_reflex1.86340498
23MP0002075_abnormal_coat/hair_pigmentati1.76415119
24MP0004264_abnormal_extraembryonic_tissu1.73712101
25MP0002102_abnormal_ear_morphology1.56309323
26MP0005085_abnormal_gallbladder_physiolo1.53291095
27MP0001984_abnormal_olfaction1.48784765
28MP0010234_abnormal_vibrissa_follicle1.47899578
29MP0005670_abnormal_white_adipose1.38006868
30MP0001186_pigmentation_phenotype1.33232101
31MP0002090_abnormal_vision1.31753683
32MP0006054_spinal_hemorrhage1.28411019
33MP0005248_abnormal_Harderian_gland1.26705972
34MP0003183_abnormal_peptide_metabolism1.22982484
35MP0001666_abnormal_nutrient_absorption1.18418281
36MP0004272_abnormal_basement_membrane1.17066831
37MP0001502_abnormal_circadian_rhythm1.09813692
38MP0009840_abnormal_foam_cell1.03902551
39MP0005365_abnormal_bile_salt1.03356098
40MP0004270_analgesia0.94089959
41MP0005253_abnormal_eye_physiology0.92711951
42MP0005167_abnormal_blood-brain_barrier0.90684410
43MP0001188_hyperpigmentation0.89863825
44MP0003172_abnormal_lysosome_physiology0.86093595
45MP0008438_abnormal_cutaneous_collagen0.83366841
46MP0005058_abnormal_lysosome_morphology0.82072542
47MP0000538_abnormal_urinary_bladder0.81712100
48MP0000569_abnormal_digit_pigmentation0.79215233
49MP0004019_abnormal_vitamin_homeostasis0.78400413
50MP0009697_abnormal_copulation0.76677404
51MP0003119_abnormal_digestive_system0.76022336
52MP0003718_maternal_effect0.74015142
53MP0000462_abnormal_digestive_system0.73988076
54MP0005266_abnormal_metabolism0.71707287
55MP0006138_congestive_heart_failure0.70915312
56MP0010329_abnormal_lipoprotein_level0.70473436
57MP0005197_abnormal_uvea_morphology0.69111811
58MP0002089_abnormal_postnatal_growth/wei0.68735903
59MP0005551_abnormal_eye_electrophysiolog0.68204541
60MP0002909_abnormal_adrenal_gland0.66034428
61MP0001501_abnormal_sleep_pattern0.63272344
62MP0001485_abnormal_pinna_reflex0.62545057
63MP0005367_renal/urinary_system_phenotyp0.58240620
64MP0000516_abnormal_urinary_system0.58240620
65MP0003195_calcinosis0.57982868
66MP0004924_abnormal_behavior0.57875777
67MP0005386_behavior/neurological_phenoty0.57875777
68MP0003283_abnormal_digestive_organ0.57735541
69MP0003646_muscle_fatigue0.56560520
70MP0000427_abnormal_hair_cycle0.55699812
71MP0002229_neurodegeneration0.55040695
72MP0002736_abnormal_nociception_after0.53469265
73MP0005448_abnormal_energy_balance0.53008061
74MP0001293_anophthalmia0.49137947
75MP0004085_abnormal_heartbeat0.48568219
76MP0000013_abnormal_adipose_tissue0.46837605
77MP0005645_abnormal_hypothalamus_physiol0.45256214
78MP0002734_abnormal_mechanical_nocicepti0.44887265
79MP0002177_abnormal_outer_ear0.42308500
80MP0005499_abnormal_olfactory_system0.41895127
81MP0005394_taste/olfaction_phenotype0.41895127
82MP0010094_abnormal_chromosome_stability0.40699852
83MP0003698_abnormal_male_reproductive0.40595268
84MP0001664_abnormal_digestion0.40444646
85MP0008770_decreased_survivor_rate0.40277243
86MP0004043_abnormal_pH_regulation0.40166328
87MP0003385_abnormal_body_wall0.39891233
88MP0002272_abnormal_nervous_system0.39355398
89MP0010678_abnormal_skin_adnexa0.38646802
90MP0002118_abnormal_lipid_homeostasis0.36075081
91MP0002557_abnormal_social/conspecific_i0.35600373
92MP0005391_vision/eye_phenotype0.35532395
93MP0008932_abnormal_embryonic_tissue0.34983032
94MP0008004_abnormal_stomach_pH0.34231082
95MP0001968_abnormal_touch/_nociception0.33946599
96MP0001764_abnormal_homeostasis0.33771436
97MP0000920_abnormal_myelination0.32637924
98MP0002970_abnormal_white_adipose0.32550565
99MP0000639_abnormal_adrenal_gland0.31615302
100MP0001661_extended_life_span0.28707029

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)9.12958819
2Aplasia/Hypoplasia of the fovea (HP:0008060)9.12958819
3Aplasia/Hypoplasia of the macula (HP:0008059)8.85887147
4Aplasia/Hypoplasia affecting the retina (HP:0008061)8.25032230
5Abnormality of the fovea (HP:0000493)7.83680960
6White forelock (HP:0002211)7.51853027
7Patchy hypopigmentation of hair (HP:0011365)7.01572525
8Blue irides (HP:0000635)6.85214651
9Ocular albinism (HP:0001107)6.40994961
10Iris hypopigmentation (HP:0007730)5.92964929
11Abnormal auditory evoked potentials (HP:0006958)5.03039160
12Hypopigmentation of the fundus (HP:0007894)4.81044262
13Generalized hypopigmentation (HP:0007513)3.64646764
14Heterochromia iridis (HP:0001100)3.62986967
15Congenital sensorineural hearing impairment (HP:0008527)3.52016334
16Bilateral sensorineural hearing impairment (HP:0008619)3.38891378
17Hypobetalipoproteinemia (HP:0003563)3.23494033
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.21059797
19Aplasia/Hypoplasia affecting the fundus (HP:0008057)3.15717643
20Abnormality of the vitamin B12 metabolism (HP:0004341)3.06676995
21Freckling (HP:0001480)3.02461696
22Abnormality of vitamin B metabolism (HP:0004340)2.80150810
23Cutaneous melanoma (HP:0012056)2.80020194
24Hypoplasia of the iris (HP:0007676)2.67016143
25Paraparesis (HP:0002385)2.59997796
26Abnormality of proline metabolism (HP:0010907)2.58464713
27Hydroxyprolinuria (HP:0003080)2.58464713
28Premature graying of hair (HP:0002216)2.40611133
29Abnormality of the fetal cardiovascular system (HP:0010948)2.30806319
30Abnormal umbilical cord blood vessels (HP:0011403)2.30806319
31Single umbilical artery (HP:0001195)2.30806319
32Albinism (HP:0001022)2.22076807
33Intestinal atresia (HP:0011100)2.19770485
34Hypoglycemic seizures (HP:0002173)2.12618700
35Hypolipoproteinemia (HP:0010981)2.11873089
36Spastic paraparesis (HP:0002313)2.04214235
37Acanthocytosis (HP:0001927)2.03347123
38Alacrima (HP:0000522)2.01833900
39Abnormality of vitamin metabolism (HP:0100508)2.01007407
40Methylmalonic aciduria (HP:0012120)2.00302751
41Anal stenosis (HP:0002025)1.99258406
42Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94950424
43Hyperinsulinemic hypoglycemia (HP:0000825)1.94660818
44Fat malabsorption (HP:0002630)1.93890015
45Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93446266
46Methylmalonic acidemia (HP:0002912)1.90157120
47Large for gestational age (HP:0001520)1.88813010
48Abnormality of sulfur amino acid metabolism (HP:0004339)1.86501680
49Decreased lacrimation (HP:0000633)1.86290797
50Synophrys (HP:0000664)1.85654117
51Generalized hypopigmentation of hair (HP:0011358)1.83882274
52J-shaped sella turcica (HP:0002680)1.81329869
53Aqueductal stenosis (HP:0002410)1.80511911
54Hypoglycemic coma (HP:0001325)1.79537779
55Cerebral aneurysm (HP:0004944)1.77502345
56Ileus (HP:0002595)1.76215090
57Amblyopia (HP:0000646)1.75087904
58Pancreatic islet-cell hyperplasia (HP:0004510)1.73849322
59Ulnar claw (HP:0001178)1.73016170
60Symptomatic seizures (HP:0011145)1.72825926
61Pigmentary retinal degeneration (HP:0001146)1.69215848
62Anterior segment dysgenesis (HP:0007700)1.68516729
63Volvulus (HP:0002580)1.66067435
64Protuberant abdomen (HP:0001538)1.64456170
65Cholecystitis (HP:0001082)1.64361840
66Abnormal gallbladder physiology (HP:0012438)1.64361840
67Type I transferrin isoform profile (HP:0003642)1.63278333
68Long clavicles (HP:0000890)1.62278902
69Malnutrition (HP:0004395)1.57648145
70Cerebral hypomyelination (HP:0006808)1.57209097
71Epidermoid cyst (HP:0200040)1.55809984
72Tongue fasciculations (HP:0001308)1.54822537
73Increased neuronal autofluorescent lipopigment (HP:0002074)1.52172752
74Congenital stationary night blindness (HP:0007642)1.50266461
75Abnormality of urine glucose concentration (HP:0011016)1.49182711
76Glycosuria (HP:0003076)1.49182711
77Hypokinesia (HP:0002375)1.49010680
78Hypophosphatemic rickets (HP:0004912)1.48884149
79Megaloblastic anemia (HP:0001889)1.47027896
80Adrenal hypoplasia (HP:0000835)1.45517630
81Abnormality of the nasal septum (HP:0000419)1.45421221
82Abnormality of the anterior chamber (HP:0000593)1.45096905
83Congenital malformation of the right heart (HP:0011723)1.44678961
84Double outlet right ventricle (HP:0001719)1.44678961
85Enlarged kidneys (HP:0000105)1.43857148
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.42337046
87Delusions (HP:0000746)1.40491350
88Ketoacidosis (HP:0001993)1.40336696
89Abnormality of chromosome stability (HP:0003220)1.38192341
90Absent epiphyses (HP:0010577)1.38054249
91Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38054249
92Abnormality of the costochondral junction (HP:0000919)1.37630706
93Abnormality of methionine metabolism (HP:0010901)1.32946154
94Hyperglycinuria (HP:0003108)1.31370816
95Abnormality of vision evoked potentials (HP:0000649)1.31262792
96Peripheral demyelination (HP:0011096)1.30955775
97Abnormality of the sella turcica (HP:0002679)1.30853763
98Increased cerebral lipofuscin (HP:0011813)1.30314024
99Retinal atrophy (HP:0001105)1.28489108
100Hand muscle atrophy (HP:0009130)1.28180021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.76740458
2FRK4.63821240
3TRIM284.28336005
4WEE14.12384719
5PDK23.44324195
6BMPR1B3.00854297
7PRKD32.80727680
8SIK32.20936193
9ERBB32.14246539
10ERBB41.94116768
11PLK41.85628332
12FER1.83227474
13WNK31.73661589
14PLK21.73279814
15MARK31.72210083
16MKNK21.72016246
17TNIK1.70012387
18NEK11.65464598
19TIE11.55948517
20MST1R1.54587189
21FGFR21.53704553
22CSNK1G21.49258302
23CAMK1D1.49225404
24CSNK1G31.42809473
25STK391.38016399
26MST41.38012348
27CSNK1G11.32522814
28PKN21.32343845
29MAPKAPK31.31944014
30BCR1.28479132
31EIF2AK31.25772651
32PRKCH1.23322182
33MKNK11.22177719
34EIF2AK11.21180467
35PRKG21.20656019
36CSNK1A1L1.20523814
37AKT31.14539845
38PRKAA21.10921198
39EPHA41.10011141
40MINK11.04390870
41CAMK1G1.01805242
42MAP3K30.98946877
43MAPK130.98594590
44MAP3K40.91154008
45MAP3K120.80556449
46IRAK20.80547885
47DAPK20.78482114
48IRAK10.78402365
49PLK30.74217934
50BRSK10.72776003
51PINK10.70021750
52NUAK10.69487693
53MET0.69006439
54DMPK0.68924630
55LMTK20.65947364
56ICK0.65464015
57CASK0.65361864
58PTK2B0.63629326
59PRKD20.63217007
60MAP3K20.60443612
61PAK40.58249074
62MAP4K20.58130469
63CDK30.57789527
64MAP3K110.56243054
65CDC70.55226547
66PBK0.55067442
67TGFBR20.53454301
68PRKD10.52967058
69MAP2K70.52773748
70CDK70.52600358
71OXSR10.51847650
72GSK3A0.51345513
73TNK20.50759741
74MATK0.49255315
75CAMK2A0.47503378
76BRSK20.46445432
77ADRBK10.45047971
78STK38L0.43819550
79PRKCE0.41590612
80DAPK10.39513248
81CSNK1A10.37565824
82BRD40.37548969
83ATM0.37517796
84PLK10.37429673
85INSRR0.34521371
86TTK0.32665691
87PRKAA10.32476200
88PRKACB0.30337584
89TGFBR10.30131977
90PAK30.29748486
91LIMK10.26290637
92ROCK10.25471382
93PRKCG0.25273170
94PRKCA0.24907661
95TAOK10.24659299
96CSNK1D0.23040318
97CSNK1E0.22946291
98PRKACA0.22249216
99FGFR10.21178552
100NEK60.20775592

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049773.27304054
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.02562193
3Fatty acid biosynthesis_Homo sapiens_hsa000612.73850639
4Renin-angiotensin system_Homo sapiens_hsa046142.48642677
5Fat digestion and absorption_Homo sapiens_hsa049752.43246116
6Non-homologous end-joining_Homo sapiens_hsa034502.37243251
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11746242
8Starch and sucrose metabolism_Homo sapiens_hsa005002.00950111
9Fatty acid metabolism_Homo sapiens_hsa012122.00573932
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88991217
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87775127
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84609986
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83538312
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.83105004
15Propanoate metabolism_Homo sapiens_hsa006401.81322910
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76684042
17Protein digestion and absorption_Homo sapiens_hsa049741.68604078
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63876661
19Chemical carcinogenesis_Homo sapiens_hsa052041.62665165
20Pyruvate metabolism_Homo sapiens_hsa006201.56366095
21ABC transporters_Homo sapiens_hsa020101.54084603
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53120464
23Butanoate metabolism_Homo sapiens_hsa006501.52311452
24Mineral absorption_Homo sapiens_hsa049781.50679888
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50282207
26Galactose metabolism_Homo sapiens_hsa000521.49363789
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.45659597
28Fatty acid elongation_Homo sapiens_hsa000621.45105028
29Fructose and mannose metabolism_Homo sapiens_hsa000511.44629959
30Caffeine metabolism_Homo sapiens_hsa002321.43770682
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42688876
32Fatty acid degradation_Homo sapiens_hsa000711.41943460
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39257617
34Sphingolipid metabolism_Homo sapiens_hsa006001.34175234
35Tyrosine metabolism_Homo sapiens_hsa003501.33580322
36Collecting duct acid secretion_Homo sapiens_hsa049661.33546255
37N-Glycan biosynthesis_Homo sapiens_hsa005101.32926697
38Bile secretion_Homo sapiens_hsa049761.29764100
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29063800
40Glutathione metabolism_Homo sapiens_hsa004801.24136167
41Tryptophan metabolism_Homo sapiens_hsa003801.19713165
42PPAR signaling pathway_Homo sapiens_hsa033201.19541939
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17380851
44Retinol metabolism_Homo sapiens_hsa008301.15870221
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15649548
46Vibrio cholerae infection_Homo sapiens_hsa051101.15236578
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15048175
48Histidine metabolism_Homo sapiens_hsa003401.12467631
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11751168
50Linoleic acid metabolism_Homo sapiens_hsa005911.10524830
51Peroxisome_Homo sapiens_hsa041461.07620043
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07378226
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07347748
54Protein export_Homo sapiens_hsa030601.05935207
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02967234
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01837445
57Arginine biosynthesis_Homo sapiens_hsa002201.00923154
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96000053
59Arginine and proline metabolism_Homo sapiens_hsa003300.95853409
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93627415
61Lysine degradation_Homo sapiens_hsa003100.88631784
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.80597962
63Melanogenesis_Homo sapiens_hsa049160.75897922
64Folate biosynthesis_Homo sapiens_hsa007900.73323541
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72085613
66Homologous recombination_Homo sapiens_hsa034400.71486693
67Ether lipid metabolism_Homo sapiens_hsa005650.71452487
68Sulfur metabolism_Homo sapiens_hsa009200.68236439
69Synaptic vesicle cycle_Homo sapiens_hsa047210.67712002
70Carbon metabolism_Homo sapiens_hsa012000.67560138
71Metabolic pathways_Homo sapiens_hsa011000.59567162
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.59041707
73Proteasome_Homo sapiens_hsa030500.58149277
74beta-Alanine metabolism_Homo sapiens_hsa004100.57148774
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.55085653
76Glycerolipid metabolism_Homo sapiens_hsa005610.54233703
77Inositol phosphate metabolism_Homo sapiens_hsa005620.53321553
78Insulin secretion_Homo sapiens_hsa049110.49890635
79Pentose phosphate pathway_Homo sapiens_hsa000300.48992165
80Lysosome_Homo sapiens_hsa041420.48642483
81Biosynthesis of amino acids_Homo sapiens_hsa012300.40366079
82Steroid biosynthesis_Homo sapiens_hsa001000.39590969
83Fanconi anemia pathway_Homo sapiens_hsa034600.39408609
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38662715
85Arachidonic acid metabolism_Homo sapiens_hsa005900.36348490
86Oocyte meiosis_Homo sapiens_hsa041140.36305968
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.35124868
88Thyroid hormone synthesis_Homo sapiens_hsa049180.34725477
89Glucagon signaling pathway_Homo sapiens_hsa049220.34411616
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34400563
91Phenylalanine metabolism_Homo sapiens_hsa003600.33267387
92Pancreatic secretion_Homo sapiens_hsa049720.31829099
93Dorso-ventral axis formation_Homo sapiens_hsa043200.31521180
94TGF-beta signaling pathway_Homo sapiens_hsa043500.29221252
95Ovarian steroidogenesis_Homo sapiens_hsa049130.29133988
96Tight junction_Homo sapiens_hsa045300.29111873
97Mismatch repair_Homo sapiens_hsa034300.27355565
98Serotonergic synapse_Homo sapiens_hsa047260.26911228
99Regulation of autophagy_Homo sapiens_hsa041400.26495169
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.25576063

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