SLC5A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* thyroid hormone metabolic process (GO:0042403)8.89670186
2synaptic vesicle exocytosis (GO:0016079)5.36499912
3response to parathyroid hormone (GO:0071107)5.34329436
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.05904679
5glutamate secretion (GO:0014047)5.05324663
6synaptic vesicle maturation (GO:0016188)4.70313908
7vocalization behavior (GO:0071625)4.69561117
8behavioral response to nicotine (GO:0035095)4.68453438
9sulfate transmembrane transport (GO:1902358)4.61516708
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59170319
11regulation of glutamate receptor signaling pathway (GO:1900449)4.46578654
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.46453637
13regulation of synaptic vesicle exocytosis (GO:2000300)4.36786775
14ATP hydrolysis coupled proton transport (GO:0015991)4.24300959
15energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.24300959
16neuron cell-cell adhesion (GO:0007158)4.16621553
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.15710547
18fucose catabolic process (GO:0019317)4.12069043
19L-fucose metabolic process (GO:0042354)4.12069043
20L-fucose catabolic process (GO:0042355)4.12069043
21sulfate transport (GO:0008272)4.10015340
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.05991984
23neurotransmitter secretion (GO:0007269)3.98874206
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94571657
25sodium ion export (GO:0071436)3.93162090
26neuronal action potential propagation (GO:0019227)3.89844346
27locomotory exploration behavior (GO:0035641)3.89643930
28proline transport (GO:0015824)3.85128645
29indolalkylamine metabolic process (GO:0006586)3.77305377
30regulation of synaptic vesicle transport (GO:1902803)3.73177690
31thyroid gland development (GO:0030878)3.67071837
32protein localization to synapse (GO:0035418)3.66764140
33acid secretion (GO:0046717)3.59495235
34cellular potassium ion homeostasis (GO:0030007)3.55991054
35water-soluble vitamin biosynthetic process (GO:0042364)3.54025461
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.52197233
37regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.51977352
38tryptophan metabolic process (GO:0006568)3.50144685
39kynurenine metabolic process (GO:0070189)3.41932436
40tryptophan catabolic process (GO:0006569)3.33784630
41indole-containing compound catabolic process (GO:0042436)3.33784630
42indolalkylamine catabolic process (GO:0046218)3.33784630
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.33338009
44exploration behavior (GO:0035640)3.31745945
45transferrin transport (GO:0033572)3.29879845
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28929231
47neuron-neuron synaptic transmission (GO:0007270)3.28238691
48protein-cofactor linkage (GO:0018065)3.26411082
49neuromuscular process controlling posture (GO:0050884)3.20472616
50neurotransmitter transport (GO:0006836)3.17607530
51regulation of neuronal synaptic plasticity (GO:0048168)3.17444971
52activation of protein kinase A activity (GO:0034199)3.16091921
53synapse assembly (GO:0007416)3.15457053
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.15285545
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14771166
56phosphorelay signal transduction system (GO:0000160)3.14041499
57synaptic transmission, glutamatergic (GO:0035249)3.12943437
58positive regulation of neurotransmitter transport (GO:0051590)3.12830251
59negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.11390589
60DNA deamination (GO:0045006)3.10717922
61cell migration in hindbrain (GO:0021535)3.10674316
62cellular ketone body metabolic process (GO:0046950)3.09643352
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09124505
64trivalent inorganic cation transport (GO:0072512)3.08566324
65ferric iron transport (GO:0015682)3.08566324
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07908642
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.07752241
68NADH dehydrogenase complex assembly (GO:0010257)3.07752241
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07752241
70regulation of neurotransmitter levels (GO:0001505)3.07359950
71glutamate receptor signaling pathway (GO:0007215)3.06239153
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05633674
73protein complex biogenesis (GO:0070271)3.04456817
74negative regulation of telomere maintenance (GO:0032205)3.03969336
75long-term synaptic potentiation (GO:0060291)3.03556010
76negative regulation of dendrite morphogenesis (GO:0050774)3.01982613
77platelet dense granule organization (GO:0060155)3.01947105
78positive regulation of sodium ion transport (GO:0010765)3.00909609
79piRNA metabolic process (GO:0034587)2.99699093
80regulation of long-term neuronal synaptic plasticity (GO:0048169)2.99377297
81response to pheromone (GO:0019236)2.98412891
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96957852
83sulfation (GO:0051923)2.95780140
84regulation of sodium ion transmembrane transporter activity (GO:2000649)2.93455923
85detection of light stimulus involved in sensory perception (GO:0050962)2.93174296
86detection of light stimulus involved in visual perception (GO:0050908)2.93174296
87kidney morphogenesis (GO:0060993)2.93049078
88layer formation in cerebral cortex (GO:0021819)2.92140771
89respiratory chain complex IV assembly (GO:0008535)2.91163264
90regulation of action potential (GO:0098900)2.91093490
91epithelial cilium movement (GO:0003351)2.91049870
92positive regulation of synapse maturation (GO:0090129)2.90117503
93mitochondrial respiratory chain complex assembly (GO:0033108)2.90112777
94preassembly of GPI anchor in ER membrane (GO:0016254)2.88423772
95postsynaptic membrane organization (GO:0001941)2.87503411
96indole-containing compound metabolic process (GO:0042430)2.87380192
97response to histamine (GO:0034776)2.86945513
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85946007
99G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85910211
100neurotransmitter-gated ion channel clustering (GO:0072578)2.84443114
101gamma-aminobutyric acid signaling pathway (GO:0007214)2.84154246
102protein polyglutamylation (GO:0018095)2.84005568
103innervation (GO:0060384)2.83889140
104negative regulation of mast cell activation (GO:0033004)2.83598446
105regulation of synaptic plasticity (GO:0048167)2.82775335
106membrane repolarization during action potential (GO:0086011)2.82076732
107regulation of mesenchymal cell apoptotic process (GO:2001053)2.81845774
108regulation of excitatory postsynaptic membrane potential (GO:0060079)2.81427566
109nephron tubule formation (GO:0072079)2.81138420
110primary amino compound metabolic process (GO:1901160)2.80672941
111neuron recognition (GO:0008038)2.79363521
112neuronal action potential (GO:0019228)2.79301514
113regulation of clathrin-mediated endocytosis (GO:2000369)2.78684422
114pyrimidine nucleobase catabolic process (GO:0006208)2.78621547
115cerebellar Purkinje cell differentiation (GO:0021702)2.78395151
116regulation of postsynaptic membrane potential (GO:0060078)2.78024965
117regulation of synapse structural plasticity (GO:0051823)2.77426277
118maintenance of gastrointestinal epithelium (GO:0030277)2.77023209
119neural tube formation (GO:0001841)2.75767019
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75720610
121regulation of neurotransmitter secretion (GO:0046928)2.74832411
122cell communication by electrical coupling (GO:0010644)2.73869097
123synaptic transmission (GO:0007268)2.72621132
124positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.72613105
125ketone body metabolic process (GO:1902224)2.72497837
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72361689
127regulation of heart rate by cardiac conduction (GO:0086091)2.71963423
128protein K11-linked deubiquitination (GO:0035871)2.71520705
129membrane hyperpolarization (GO:0060081)2.71348617
130membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.71255133
131calcium ion-dependent exocytosis (GO:0017156)2.70988631
132positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70299418
133regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69919280
134axoneme assembly (GO:0035082)2.69695082
135photoreceptor cell development (GO:0042461)2.69344047
136hormone biosynthetic process (GO:0042446)2.69245576
137serotonin metabolic process (GO:0042428)2.67316158
138regulation of vesicle fusion (GO:0031338)2.67225118
139regulation of neurotransmitter transport (GO:0051588)2.67003626
140presynaptic membrane assembly (GO:0097105)2.66960924
141gamma-aminobutyric acid transport (GO:0015812)2.66603775
142positive regulation of membrane potential (GO:0045838)2.66025707
143cell communication involved in cardiac conduction (GO:0086065)2.66013428
144bicarbonate transport (GO:0015701)2.65780754
145negative regulation of hormone metabolic process (GO:0032351)2.65470957
146negative regulation of hormone biosynthetic process (GO:0032353)2.65470957
147positive regulation of digestive system process (GO:0060456)2.65016147
148regulation of nuclear cell cycle DNA replication (GO:0033262)2.64681278
149regulation of synaptic transmission, glutamatergic (GO:0051966)2.64616236
150positive regulation of synaptic transmission (GO:0050806)2.64412695
151negative regulation of microtubule polymerization (GO:0031115)2.64346997
152embryonic epithelial tube formation (GO:0001838)2.63434020
153regulation of sodium ion transmembrane transport (GO:1902305)2.62698436
154synaptic vesicle endocytosis (GO:0048488)2.62407697
155pseudouridine synthesis (GO:0001522)2.61193189
156nucleobase catabolic process (GO:0046113)2.60115598
157behavioral response to ethanol (GO:0048149)2.57034835
158ubiquinone biosynthetic process (GO:0006744)2.56614620
159female gonad development (GO:0008585)2.56151485
160regulation of glucokinase activity (GO:0033131)2.55403611
161regulation of hexokinase activity (GO:1903299)2.55403611
162ubiquinone metabolic process (GO:0006743)2.53859791
163ATP synthesis coupled proton transport (GO:0015986)2.53756423
164energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53756423
165cytochrome complex assembly (GO:0017004)2.52014689
166reflex (GO:0060004)2.51102071
167DNA methylation involved in gamete generation (GO:0043046)2.51017576
168cilium morphogenesis (GO:0060271)2.50082938
169hydrogen peroxide catabolic process (GO:0042744)2.49749577
170negative regulation of DNA-dependent DNA replication (GO:2000104)2.49400679
171mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.49253418
172* phenol-containing compound metabolic process (GO:0018958)2.48880133
173establishment of protein localization to mitochondrial membrane (GO:0090151)2.46721904
174retinal cone cell development (GO:0046549)2.46613891
175regulation of cilium movement (GO:0003352)2.45965468
176somatic hypermutation of immunoglobulin genes (GO:0016446)2.45536273
177somatic diversification of immune receptors via somatic mutation (GO:0002566)2.45536273
178negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45307310
179epithelial tube formation (GO:0072175)2.44886214
180nephron epithelium morphogenesis (GO:0072088)2.44113373
181nephron tubule morphogenesis (GO:0072078)2.44113373
182negative regulation of transcription regulatory region DNA binding (GO:2000678)2.43830994
183mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.43239275
184GPI anchor metabolic process (GO:0006505)2.42845780
185eye photoreceptor cell development (GO:0042462)2.41862467
186sulfur compound transport (GO:0072348)2.39882878
187dopamine transport (GO:0015872)2.39361358
188phosphatidylinositol acyl-chain remodeling (GO:0036149)2.36711829
189negative regulation of metanephros development (GO:0072217)2.36235352
190photoreceptor cell maintenance (GO:0045494)2.35868493
191amine catabolic process (GO:0009310)2.35738313
192cellular biogenic amine catabolic process (GO:0042402)2.35738313
193positive regulation of fatty acid transport (GO:2000193)2.35378172
194* thyroid hormone generation (GO:0006590)10.7565161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.03576112
2GBX2_23144817_ChIP-Seq_PC3_Human3.64605259
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04718462
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93698727
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65770485
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61315262
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.61109062
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.55570067
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54101789
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54101789
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46778218
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42500950
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38906867
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29283059
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28297239
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28260697
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.27216519
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.23446311
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20096545
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15871381
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10815355
22DROSHA_22980978_ChIP-Seq_HELA_Human2.09578892
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07345943
24TAF15_26573619_Chip-Seq_HEK293_Human2.04249501
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.00304110
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.99625732
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.99414353
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.99321999
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99033674
30FUS_26573619_Chip-Seq_HEK293_Human1.96355434
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95597089
32* REST_18959480_ChIP-ChIP_MESCs_Mouse1.91845952
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91477042
34EWS_26573619_Chip-Seq_HEK293_Human1.90444329
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.90264987
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89814735
37IRF1_19129219_ChIP-ChIP_H3396_Human1.88749203
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.87973008
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87805070
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.84291647
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.81576508
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.79791751
43ER_23166858_ChIP-Seq_MCF-7_Human1.79313180
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.79155666
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.77812681
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77407483
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70636116
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70520943
49BCAT_22108803_ChIP-Seq_LS180_Human1.70286233
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69470609
51AR_21572438_ChIP-Seq_LNCaP_Human1.67783588
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63506695
53* TP53_22573176_ChIP-Seq_HFKS_Human1.61553449
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58133597
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57394577
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.57039690
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56485404
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53304117
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52525241
60SMAD4_21799915_ChIP-Seq_A2780_Human1.48115220
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48028401
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46390431
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45892995
64AHR_22903824_ChIP-Seq_MCF-7_Human1.40912152
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40781030
66CBP_20019798_ChIP-Seq_JUKART_Human1.40781030
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39989071
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39382773
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39299134
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.38806867
71MYC_18940864_ChIP-ChIP_HL60_Human1.38369192
72* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37898657
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36784379
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36423695
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36094147
76SOX2_19829295_ChIP-Seq_ESCs_Human1.35739764
77NANOG_19829295_ChIP-Seq_ESCs_Human1.35739764
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35423454
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33933166
80VDR_22108803_ChIP-Seq_LS180_Human1.33161358
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32910942
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32910942
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.29885649
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.29579205
85ZNF274_21170338_ChIP-Seq_K562_Hela1.28594741
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28575579
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27830443
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27828328
89FOXA1_25329375_ChIP-Seq_VCAP_Human1.27828328
90* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26628925
91TCF4_23295773_ChIP-Seq_U87_Human1.24927687
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24711325
93TCF4_22108803_ChIP-Seq_LS180_Human1.24322383
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.21692693
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21240589
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.20601351
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19546984
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19407499
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.18979327
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17882261
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16893341
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.15580509
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.14712613
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14310391
105VDR_23849224_ChIP-Seq_CD4+_Human1.14182025
106EP300_21415370_ChIP-Seq_HL-1_Mouse1.13932363
107IGF1R_20145208_ChIP-Seq_DFB_Human1.13858184
108HOXB7_26014856_ChIP-Seq_BT474_Human1.13502105
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.12410941
110KLF5_25053715_ChIP-Seq_YYC3_Human1.12235459
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12103843
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.11147584
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10493103
114P300_19829295_ChIP-Seq_ESCs_Human1.10473654
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10469837
116AR_20517297_ChIP-Seq_VCAP_Human1.10360906
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.10102148
118NCOR_22424771_ChIP-Seq_293T_Human1.09968108
119AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09628352
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09565262
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.07940103
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07627791
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07295096
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05974968
125ELK1_19687146_ChIP-ChIP_HELA_Human1.05908443
126AR_25329375_ChIP-Seq_VCAP_Human1.05783534
127AR_19668381_ChIP-Seq_PC3_Human1.05734698
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05518416
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.05451035
130YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05215727
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04541722
132EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03677311
133RING1B_27294783_Chip-Seq_NPCs_Mouse1.02672653
134WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02331606
135P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02308920
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01878625
137FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01537017
138PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00704138
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99825857
140STAT3_23295773_ChIP-Seq_U87_Human0.99038428
141NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96163945
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95672980
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95654688
144SMAD3_21741376_ChIP-Seq_HESCs_Human0.95013503
145SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94166959
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93757079
147RNF2_27304074_Chip-Seq_NSC_Mouse0.93712976
148SMAD4_21741376_ChIP-Seq_HESCs_Human0.93234614
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93015043
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92032515
151MYC_19829295_ChIP-Seq_ESCs_Human0.91701635
152CDX2_22108803_ChIP-Seq_LS180_Human0.91510324
153EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91431775
154POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90877526
155SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90552675
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.90248573
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.89681361
158CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89448652
159NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89225640
160FOXH1_21741376_ChIP-Seq_EPCs_Human0.88950772
161ERA_21632823_ChIP-Seq_H3396_Human0.88786233
162TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88087620
163TP53_16413492_ChIP-PET_HCT116_Human0.87769506
164* KDM2B_26808549_Chip-Seq_K562_Human0.86937366
165TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86935612
166* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86863782
167* CTCF_27219007_Chip-Seq_Bcells_Human0.86218033
168RXR_22108803_ChIP-Seq_LS180_Human0.85118548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH6.96994574
2MP0004859_abnormal_synaptic_plasticity4.51152060
3MP0003880_abnormal_central_pattern3.47905008
4MP0004270_analgesia3.41990473
5MP0003635_abnormal_synaptic_transmissio3.23662424
6MP0000681_abnormal_thyroid_gland2.84595455
7MP0002064_seizures2.77822873
8MP0001485_abnormal_pinna_reflex2.73711497
9MP0009745_abnormal_behavioral_response2.73530976
10MP0001664_abnormal_digestion2.73398182
11MP0001968_abnormal_touch/_nociception2.69045220
12MP0002735_abnormal_chemical_nociception2.65729554
13MP0009046_muscle_twitch2.62783602
14MP0002063_abnormal_learning/memory/cond2.61724003
15MP0002736_abnormal_nociception_after2.54775387
16MP0002734_abnormal_mechanical_nocicepti2.52119689
17MP0002572_abnormal_emotion/affect_behav2.36521484
18MP0002272_abnormal_nervous_system2.34848541
19MP0004858_abnormal_nervous_system2.33376819
20MP0005551_abnormal_eye_electrophysiolog2.21602464
21MP0008875_abnormal_xenobiotic_pharmacok2.15740314
22MP0001440_abnormal_grooming_behavior2.15049144
23MP0006292_abnormal_olfactory_placode2.12029977
24MP0001986_abnormal_taste_sensitivity2.11710703
25MP0006276_abnormal_autonomic_nervous2.10455473
26MP0002102_abnormal_ear_morphology2.10350878
27MP0003122_maternal_imprinting2.10028161
28MP0000678_abnormal_parathyroid_gland2.08685122
29MP0004742_abnormal_vestibular_system2.07067265
30MP0001501_abnormal_sleep_pattern1.97321407
31MP0003195_calcinosis1.87707124
32MP0009780_abnormal_chondrocyte_physiolo1.85129529
33MP0001970_abnormal_pain_threshold1.78952250
34MP0000569_abnormal_digit_pigmentation1.78592624
35MP0004043_abnormal_pH_regulation1.78474598
36MP0000631_abnormal_neuroendocrine_gland1.78179398
37MP0003136_yellow_coat_color1.76174537
38MP0002733_abnormal_thermal_nociception1.71248289
39MP0000372_irregular_coat_pigmentation1.71070613
40MP0002876_abnormal_thyroid_physiology1.66195001
41MP0006072_abnormal_retinal_apoptosis1.65973126
42MP0001486_abnormal_startle_reflex1.64880596
43MP0001529_abnormal_vocalization1.57922980
44MP0002067_abnormal_sensory_capabilities1.56086550
45MP0002822_catalepsy1.54497095
46MP0010234_abnormal_vibrissa_follicle1.50840513
47MP0002638_abnormal_pupillary_reflex1.47128592
48MP0008569_lethality_at_weaning1.45916324
49MP0005423_abnormal_somatic_nervous1.42899313
50MP0003787_abnormal_imprinting1.41309218
51MP0004133_heterotaxia1.40663638
52MP0000470_abnormal_stomach_morphology1.38484503
53MP0003879_abnormal_hair_cell1.36912451
54MP0004811_abnormal_neuron_physiology1.36292604
55MP0002557_abnormal_social/conspecific_i1.35969924
56MP0004147_increased_porphyrin_level1.35317983
57MP0002909_abnormal_adrenal_gland1.34101391
58MP0005253_abnormal_eye_physiology1.33603301
59MP0004924_abnormal_behavior1.33329371
60MP0005386_behavior/neurological_phenoty1.33329371
61MP0002138_abnormal_hepatobiliary_system1.31367793
62MP0005084_abnormal_gallbladder_morpholo1.31314551
63MP0003123_paternal_imprinting1.28843109
64MP0002184_abnormal_innervation1.26538208
65MP0004142_abnormal_muscle_tone1.25014790
66MP0000026_abnormal_inner_ear1.23385511
67MP0004484_altered_response_of1.22571876
68MP0003329_amyloid_beta_deposits1.22027496
69MP0003646_muscle_fatigue1.18962086
70MP0003718_maternal_effect1.17050929
71MP0000427_abnormal_hair_cycle1.16575541
72MP0001873_stomach_inflammation1.15183621
73MP0002938_white_spotting1.13670784
74MP0003011_delayed_dark_adaptation1.12487110
75MP0005389_reproductive_system_phenotype1.09799216
76MP0010678_abnormal_skin_adnexa1.08321710
77MP0002928_abnormal_bile_duct1.04613845
78MP0002066_abnormal_motor_capabilities/c1.04417002
79MP0002160_abnormal_reproductive_system1.04358348
80MP0000955_abnormal_spinal_cord1.03284204
81MP0002163_abnormal_gland_morphology1.02555696
82MP0003938_abnormal_ear_development1.02377106
83MP0004233_abnormal_muscle_weight1.02126270
84MP0005645_abnormal_hypothalamus_physiol1.02045899
85MP0008995_early_reproductive_senescence1.02005671
86MP0003890_abnormal_embryonic-extraembry1.00215416
87MP0002882_abnormal_neuron_morphology0.97928598
88MP0008872_abnormal_physiological_respon0.97866247
89MP0000049_abnormal_middle_ear0.97256874
90MP0001663_abnormal_digestive_system0.96433832
91MP0005646_abnormal_pituitary_gland0.96282089
92MP0003698_abnormal_male_reproductive0.95191279
93MP0000778_abnormal_nervous_system0.94663507
94MP0002837_dystrophic_cardiac_calcinosis0.94211998
95MP0005165_increased_susceptibility_to0.94088946
96MP0005174_abnormal_tail_pigmentation0.93103334
97MP0001905_abnormal_dopamine_level0.92483556
98MP0003567_abnormal_fetal_cardiomyocyte0.92132155
99MP0001919_abnormal_reproductive_system0.91750067
100MP0001502_abnormal_circadian_rhythm0.91306761
101MP0000751_myopathy0.90705659
102MP0002752_abnormal_somatic_nervous0.88867661
103MP0005381_digestive/alimentary_phenotyp0.88492883
104MP0005195_abnormal_posterior_eye0.87934651
105MP0000383_abnormal_hair_follicle0.87775889
106MP0005379_endocrine/exocrine_gland_phen0.87699114
107MP0008961_abnormal_basal_metabolism0.87167369
108MP0002234_abnormal_pharynx_morphology0.85676417
109MP0003937_abnormal_limbs/digits/tail_de0.85302796
110MP0002254_reproductive_system_inflammat0.82874276
111MP0006035_abnormal_mitochondrial_morpho0.82795432
112MP0001188_hyperpigmentation0.82185577
113MP0002751_abnormal_autonomic_nervous0.82037204
114MP0002210_abnormal_sex_determination0.81513645
115MP0001929_abnormal_gametogenesis0.81023512
116MP0008058_abnormal_DNA_repair0.80767428
117MP0002152_abnormal_brain_morphology0.79614362
118MP0003119_abnormal_digestive_system0.79216570
119MP0003633_abnormal_nervous_system0.78908709
120MP0005410_abnormal_fertilization0.78833433
121MP0000534_abnormal_ureter_morphology0.78233819
122MP0005171_absent_coat_pigmentation0.77627836
123MP0004036_abnormal_muscle_relaxation0.77594625
124MP0002069_abnormal_eating/drinking_beha0.76986590
125MP0001293_anophthalmia0.76405143
126MP0004145_abnormal_muscle_electrophysio0.75970611
127MP0000653_abnormal_sex_gland0.75434314
128MP0003137_abnormal_impulse_conducting0.74911678
129MP0001984_abnormal_olfaction0.74459372
130MP0000462_abnormal_digestive_system0.74291081
131MP0003075_altered_response_to0.74165856
132MP0005377_hearing/vestibular/ear_phenot0.73927527
133MP0000537_abnormal_urethra_morphology0.73876745
134MP0001963_abnormal_hearing_physiology0.73209896
135MP0003121_genomic_imprinting0.73006538
136MP0002332_abnormal_exercise_endurance0.71233376
137MP0004264_abnormal_extraembryonic_tissu0.70073445
138MP0003631_nervous_system_phenotype0.69848653
139MP0003283_abnormal_digestive_organ0.68785864
140MP0004084_abnormal_cardiac_muscle0.67471458
141MP0005535_abnormal_body_temperature0.67373667
142MP0008874_decreased_physiological_sensi0.65244096
143MP0002653_abnormal_ependyma_morphology0.63344076
144MP0003638_abnormal_response/metabolism_0.62258450
145MP0004885_abnormal_endolymph0.60411663
146MP0008877_abnormal_DNA_methylation0.60290784
147MP0005167_abnormal_blood-brain_barrier0.60026874
148MP0000013_abnormal_adipose_tissue0.57359066
149MP0001881_abnormal_mammary_gland0.56473973
150MP0002229_neurodegeneration0.56114550
151MP0003953_abnormal_hormone_level0.56108191
152MP0005623_abnormal_meninges_morphology0.54947763
153MP0005499_abnormal_olfactory_system0.53848176
154MP0005394_taste/olfaction_phenotype0.53848176

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)6.38617854
2Focal motor seizures (HP:0011153)5.99099711
3* Goiter (HP:0000853)5.79811829
4Myokymia (HP:0002411)5.56542902
5Congenital sensorineural hearing impairment (HP:0008527)4.46247130
6Focal seizures (HP:0007359)4.25532899
7Atonic seizures (HP:0010819)4.07388302
8Hypothermia (HP:0002045)4.06052744
9Pancreatic cysts (HP:0001737)4.03848431
10Thyroid-stimulating hormone excess (HP:0002925)3.79938604
11Visual hallucinations (HP:0002367)3.72125690
12Epileptic encephalopathy (HP:0200134)3.71569137
13Pancreatic fibrosis (HP:0100732)3.66565063
14Molar tooth sign on MRI (HP:0002419)3.50505375
15Abnormality of midbrain morphology (HP:0002418)3.50505375
16True hermaphroditism (HP:0010459)3.48498511
17* Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)3.46069765
18Congenital stationary night blindness (HP:0007642)3.42525693
19Abnormal hair laboratory examination (HP:0003328)3.37250744
20Febrile seizures (HP:0002373)3.33675431
21Pheochromocytoma (HP:0002666)3.32595301
22Absence seizures (HP:0002121)3.31266011
23Type II lissencephaly (HP:0007260)3.27829007
24Impaired vibration sensation in the lower limbs (HP:0002166)3.24816838
25Progressive cerebellar ataxia (HP:0002073)3.21484601
26Hyperphosphatemia (HP:0002905)3.19183905
27Generalized tonic-clonic seizures (HP:0002069)3.17226276
28Abnormality of cochlea (HP:0000375)3.14986216
29Oligomenorrhea (HP:0000876)3.12023089
30Onycholysis (HP:0001806)3.08168306
31Nephronophthisis (HP:0000090)3.07215738
32Abnormality of the labia minora (HP:0012880)3.07120419
33Neuroendocrine neoplasm (HP:0100634)2.84866408
34Pendular nystagmus (HP:0012043)2.80918591
35Dialeptic seizures (HP:0011146)2.79128436
36Small epiphyses (HP:0010585)2.78476834
37Action tremor (HP:0002345)2.77810708
38Abolished electroretinogram (ERG) (HP:0000550)2.73593268
39Morphological abnormality of the inner ear (HP:0011390)2.71885029
40Medial flaring of the eyebrow (HP:0010747)2.67778223
41Concave nail (HP:0001598)2.67114041
42Abnormality of the renal cortex (HP:0011035)2.66322231
43Attenuation of retinal blood vessels (HP:0007843)2.63963502
44Abnormality of the renal medulla (HP:0100957)2.60893047
45Anxiety (HP:0000739)2.59061987
46Abnormal eating behavior (HP:0100738)2.55953341
47Tetany (HP:0001281)2.55612767
48Chronic hepatic failure (HP:0100626)2.52662811
49Failure to thrive in infancy (HP:0001531)2.50627306
50Ventricular fibrillation (HP:0001663)2.47264155
51Resting tremor (HP:0002322)2.45241587
52Diplopia (HP:0000651)2.44999864
53Abnormality of binocular vision (HP:0011514)2.44999864
54Insidious onset (HP:0003587)2.43092407
55Termporal pattern (HP:0011008)2.43092407
56Thyroid carcinoma (HP:0002890)2.42389510
57Broad-based gait (HP:0002136)2.40883418
58Dysdiadochokinesis (HP:0002075)2.40748818
59Hyperventilation (HP:0002883)2.38902602
60Abnormality of the lower motor neuron (HP:0002366)2.38572727
61Tubular atrophy (HP:0000092)2.36827205
62Abnormal rod and cone electroretinograms (HP:0008323)2.36667745
63Irregular epiphyses (HP:0010582)2.36565244
64Polyphagia (HP:0002591)2.35699295
65Polydipsia (HP:0001959)2.35000778
66Abnormal drinking behavior (HP:0030082)2.35000778
67Ankle clonus (HP:0011448)2.34483409
68Cystic liver disease (HP:0006706)2.33527633
69Dysmetria (HP:0001310)2.32864594
70Large for gestational age (HP:0001520)2.31420968
71Abnormality of pain sensation (HP:0010832)2.30220572
72Impaired pain sensation (HP:0007328)2.30220572
73Congenital, generalized hypertrichosis (HP:0004540)2.29805924
743-Methylglutaconic aciduria (HP:0003535)2.29617595
75Urinary urgency (HP:0000012)2.29315408
76Keratoconus (HP:0000563)2.28093284
77Increased corneal curvature (HP:0100692)2.28093284
78Lissencephaly (HP:0001339)2.28063817
79Fetal akinesia sequence (HP:0001989)2.27163741
80Hypoventilation (HP:0002791)2.26862557
81Abnormal hair whorl (HP:0010721)2.26554930
82Amblyopia (HP:0000646)2.23986838
83Supranuclear gaze palsy (HP:0000605)2.22968204
84Sleep apnea (HP:0010535)2.22659117
85Depression (HP:0000716)2.22139421
86Decreased circulating renin level (HP:0003351)2.22121803
87Right ventricular cardiomyopathy (HP:0011663)2.21605278
88Poor suck (HP:0002033)2.21089623
89Progressive inability to walk (HP:0002505)2.20943319
90Abnormal biliary tract physiology (HP:0012439)2.19148881
91Bile duct proliferation (HP:0001408)2.19148881
92Abnormality of alanine metabolism (HP:0010916)2.17926114
93Hyperalaninemia (HP:0003348)2.17926114
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17926114
95Cerebellar dysplasia (HP:0007033)2.16284977
96Abnormality of the vocal cords (HP:0008777)2.15456470
97Hyperglycinuria (HP:0003108)2.14081153
98Delayed epiphyseal ossification (HP:0002663)2.13188833
99Absent/shortened dynein arms (HP:0200106)2.13185231
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.13185231
101Hemiplegia (HP:0002301)2.11535470
102Neoplasm of the peripheral nervous system (HP:0100007)2.11263624
103Mitochondrial inheritance (HP:0001427)2.11052056
104Hyperthyroidism (HP:0000836)2.10753926
105Sclerocornea (HP:0000647)2.10159601
106Gait imbalance (HP:0002141)2.07101692
107Truncal ataxia (HP:0002078)2.05057391
108Increased CSF lactate (HP:0002490)2.05048128
109Impaired social interactions (HP:0000735)2.03450208
110Abnormal social behavior (HP:0012433)2.03450208
111Labial hypoplasia (HP:0000066)2.03018309
112Postural instability (HP:0002172)2.02730731
113Decreased central vision (HP:0007663)2.00226880
114Acute encephalopathy (HP:0006846)2.00115653
115Urinary bladder sphincter dysfunction (HP:0002839)2.00070389
116Abnormality of the pons (HP:0007361)1.99692719
117Stomach cancer (HP:0012126)1.98555810
118Bronchomalacia (HP:0002780)1.97717453
119Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95508143
120Hypoparathyroidism (HP:0000829)1.95088859
121Chorioretinal atrophy (HP:0000533)1.94648557
122Congenital primary aphakia (HP:0007707)1.94400207
123Aplasia/hypoplasia of the uterus (HP:0008684)1.94021066
124Bradykinesia (HP:0002067)1.92040520
125Severe muscular hypotonia (HP:0006829)1.91737541
126Renal cortical cysts (HP:0000803)1.90569841
127Hypoplasia of the pons (HP:0012110)1.90010227
128Bilateral microphthalmos (HP:0007633)1.89999009
129Drooling (HP:0002307)1.89140403
130Excessive salivation (HP:0003781)1.89140403
131Poor eye contact (HP:0000817)1.88838942
132Polyuria (HP:0000103)1.88600368
133Scanning speech (HP:0002168)1.88596133
134Hepatocellular necrosis (HP:0001404)1.87467568
135Shoulder girdle muscle weakness (HP:0003547)1.86814836
136Nephrogenic diabetes insipidus (HP:0009806)1.86746662
137Inability to walk (HP:0002540)1.86693702
138Progressive macrocephaly (HP:0004481)1.86553323
139Anencephaly (HP:0002323)1.86487362
140Narrow nasal bridge (HP:0000446)1.86023554
141Optic disc pallor (HP:0000543)1.85729519
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85405415
143Furrowed tongue (HP:0000221)1.85248438
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.84427332
145Neuronal loss in central nervous system (HP:0002529)1.84232242
146Specific learning disability (HP:0001328)1.83554811
147Hyperglycinemia (HP:0002154)1.83249865
148Generalized hypotonia (HP:0001290)1.81895061
149Impaired vibratory sensation (HP:0002495)1.81631403
150* Hypothyroidism (HP:0000821)1.80769195
151Spastic gait (HP:0002064)1.80601729
152Ulnar claw (HP:0001178)1.80179066
153Abnormal respiratory epithelium morphology (HP:0012253)1.80131536
154Abnormal respiratory motile cilium morphology (HP:0005938)1.80131536
155Hypoplastic female external genitalia (HP:0012815)1.79960166
156Congenital hepatic fibrosis (HP:0002612)1.79648270
157Lipid accumulation in hepatocytes (HP:0006561)1.78211044
158Methylmalonic acidemia (HP:0002912)1.77921225
159Hemiparesis (HP:0001269)1.77227350
160Male pseudohermaphroditism (HP:0000037)1.76555181
161Syncope (HP:0001279)1.76219735
162Gaze-evoked nystagmus (HP:0000640)1.75991033
163Abnormality of the corticospinal tract (HP:0002492)1.74831287
164Genital tract atresia (HP:0001827)1.74571087
165Abnormality of glycine metabolism (HP:0010895)1.74448148
166Abnormality of serine family amino acid metabolism (HP:0010894)1.74448148
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74385096
168Bony spicule pigmentary retinopathy (HP:0007737)1.72756990
169Aplasia/Hypoplasia of the tongue (HP:0010295)1.72704418
170Hepatic necrosis (HP:0002605)1.72653523
171Curly hair (HP:0002212)1.70071547
172Agitation (HP:0000713)1.68585629
173Epileptiform EEG discharges (HP:0011182)1.68295858
174Focal dystonia (HP:0004373)1.67394488
175Genetic anticipation (HP:0003743)1.65590463
176Incomplete penetrance (HP:0003829)1.65547331
177Abnormal mitochondria in muscle tissue (HP:0008316)1.65371306
178Rapidly progressive (HP:0003678)1.65008522
179Acute necrotizing encephalopathy (HP:0006965)1.64561354
180Psychosis (HP:0000709)1.64543939
181Torticollis (HP:0000473)1.64070529
182Anosmia (HP:0000458)1.64005862
183* Constipation (HP:0002019)1.63240655
184Hypercortisolism (HP:0001578)1.62842797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.78005535
2MAP3K123.95918693
3NTRK33.84235659
4CASK3.54736336
5MAP3K93.48801830
6ADRBK23.42238860
7MAP3K43.19758112
8ZAK3.04297464
9WNK32.91024631
10BMPR1B2.76904288
11ERBB42.64142512
12MINK12.56458865
13GRK12.52744793
14PINK12.49064046
15MAP2K72.38314464
16DAPK22.37721026
17TLK12.37663388
18MAP4K22.36416024
19CDK192.20689468
20AKT32.18853924
21NUAK12.18794325
22MAP2K42.17635062
23EPHA42.11683142
24WNK42.05138209
25DAPK12.04832141
26KSR22.02668540
27ACVR1B1.99063920
28MST41.89792983
29TXK1.77352519
30TAOK31.73489213
31EPHA21.58417075
32NEK11.57772407
33DYRK21.57023007
34NTRK11.53219247
35LATS21.52706290
36TSSK61.52551247
37VRK11.52292767
38PNCK1.51079004
39MAP3K21.50292436
40GRK51.48051118
41RIPK41.47986453
42PLK21.42968535
43TNIK1.42796041
44OXSR11.37612977
45PAK61.34729062
46INSRR1.34480254
47BCKDK1.32872245
48MKNK21.28768613
49FER1.27481068
50TRIM281.27022174
51ARAF1.25724403
52PDK41.24849003
53PDK31.24849003
54MAP2K11.23262178
55KSR11.19370260
56NME11.17805768
57MYLK1.17331280
58PRKCG1.16439401
59LMTK21.15337775
60CDK51.10994925
61TIE11.08274987
62MARK11.05854583
63BCR1.01445808
64CSNK1G20.99652532
65DAPK30.96961229
66CAMK2B0.95659818
67GRK70.95312538
68PRKD30.90374964
69CAMK2A0.89913642
70RET0.89902527
71NTRK20.89394548
72PAK30.89116685
73EIF2AK30.88223432
74STK390.88014380
75TGFBR10.87707964
76TYRO30.86940549
77VRK20.86669231
78TAF10.84971557
79STK380.80227539
80CSNK1G10.79810328
81EPHA30.79764139
82PLK30.78766780
83CAMKK20.76380305
84CAMK10.75857963
85CDK140.74864141
86PDK20.74634676
87ROCK20.74499420
88UHMK10.73310132
89CAMK2G0.72236587
90FGFR20.71161451
91RPS6KA20.71095250
92ALK0.71004778
93CSNK1G30.70238055
94CAMK2D0.69308061
95CDK180.67910015
96CAMKK10.67472579
97SIK30.65897862
98ADRBK10.64373372
99MAPK150.63182185
100MKNK10.62653051
101MAPK130.62305881
102TAOK10.62190523
103PKN10.61717415
104CDK150.61562195
105TEC0.60996015
106MAP2K60.60019207
107IKBKB0.59929522
108LIMK10.59902670
109PRKCI0.58814484
110CSNK1A10.58384719
111PTK2B0.58212654
112RPS6KA50.58038558
113CSNK1A1L0.57502173
114PRKCZ0.57293650
115PHKG10.56750720
116PHKG20.56750720
117PLK40.56503514
118ERBB30.56097184
119CAMK1G0.54655775
120MAP3K10.53337795
121PIK3CA0.52121830
122PRKCQ0.52033543
123SGK4940.50742021
124SGK2230.50742021
125TESK10.50702044
126CDK11A0.50698495
127PDPK10.50164665
128PRPF4B0.49475132
129MST1R0.49224329
130PRKACA0.48658906
131BRAF0.47870242
132STK38L0.47534337
133BRSK20.47189071
134PTK20.47107756
135PDK10.46683478
136PRKCE0.46319447
137DDR20.45721237
138STK160.44977519
139CHUK0.44750022
140CSNK1E0.43406247
141PLK10.42260061
142ROCK10.41471776
143SGK10.41155349
144FES0.39952772
145MAPKAPK30.39153357
146MAP2K20.39011683
147MAPKAPK50.38887405
148EIF2AK20.38665264
149PAK40.38350775
150SGK20.37421622
151SRC0.37393959
152CSNK1D0.37121541
153DYRK1A0.36619520
154ERBB20.35528039
155NLK0.34537283
156MUSK0.33146546
157TNK20.33135844
158STK110.32779053
159PRKCA0.32591180
160FGFR10.31981454
161CHEK20.31709091
162SGK30.31599618
163ATR0.31412130
164PRKG10.31176662
165STK30.31096827
166PRKAA10.29997234

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.14795509
2Synaptic vesicle cycle_Homo sapiens_hsa047213.59009459
3Gastric acid secretion_Homo sapiens_hsa049713.25284353
4Nicotine addiction_Homo sapiens_hsa050332.81391161
5Linoleic acid metabolism_Homo sapiens_hsa005912.47953169
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.45395656
7Selenocompound metabolism_Homo sapiens_hsa004502.42349062
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39938200
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31690215
10Caffeine metabolism_Homo sapiens_hsa002322.21383349
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15106859
12Olfactory transduction_Homo sapiens_hsa047402.11997384
13Long-term potentiation_Homo sapiens_hsa047202.10318485
14Vibrio cholerae infection_Homo sapiens_hsa051102.08700729
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08144069
16Autoimmune thyroid disease_Homo sapiens_hsa053202.04256949
17GABAergic synapse_Homo sapiens_hsa047272.04229759
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02935652
19* Thyroid hormone synthesis_Homo sapiens_hsa049182.00713453
20Tryptophan metabolism_Homo sapiens_hsa003801.99319670
21Salivary secretion_Homo sapiens_hsa049701.95387379
22RNA polymerase_Homo sapiens_hsa030201.94978830
23Protein export_Homo sapiens_hsa030601.94647351
24Butanoate metabolism_Homo sapiens_hsa006501.94188620
25Circadian entrainment_Homo sapiens_hsa047131.93347546
26Amphetamine addiction_Homo sapiens_hsa050311.92346272
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.87116207
28Basal transcription factors_Homo sapiens_hsa030221.83479160
29Ether lipid metabolism_Homo sapiens_hsa005651.81037787
30Oxidative phosphorylation_Homo sapiens_hsa001901.77612888
31Glutamatergic synapse_Homo sapiens_hsa047241.75756480
32Morphine addiction_Homo sapiens_hsa050321.75105518
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.72547372
34Dopaminergic synapse_Homo sapiens_hsa047281.69009583
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60283065
36Taste transduction_Homo sapiens_hsa047421.59094434
37Insulin secretion_Homo sapiens_hsa049111.59080706
38Homologous recombination_Homo sapiens_hsa034401.48813323
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45818619
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42419702
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34411164
42Renin secretion_Homo sapiens_hsa049241.33844669
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33688126
44Cholinergic synapse_Homo sapiens_hsa047251.32749922
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31890194
46Long-term depression_Homo sapiens_hsa047301.31084833
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28349406
48Propanoate metabolism_Homo sapiens_hsa006401.27577541
49Fanconi anemia pathway_Homo sapiens_hsa034601.26147303
50Serotonergic synapse_Homo sapiens_hsa047261.25871996
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25411990
52Calcium signaling pathway_Homo sapiens_hsa040201.20799294
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.20186311
54Peroxisome_Homo sapiens_hsa041461.18994526
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18823936
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18802278
57Gap junction_Homo sapiens_hsa045401.18609090
58Cocaine addiction_Homo sapiens_hsa050301.18478872
59Melanogenesis_Homo sapiens_hsa049161.17936998
60Oxytocin signaling pathway_Homo sapiens_hsa049211.17362238
61GnRH signaling pathway_Homo sapiens_hsa049121.12526516
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09414444
63Cardiac muscle contraction_Homo sapiens_hsa042601.08588695
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08185477
65Arachidonic acid metabolism_Homo sapiens_hsa005901.08049718
66Fat digestion and absorption_Homo sapiens_hsa049751.06951246
67RNA degradation_Homo sapiens_hsa030181.05874927
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05476719
69Regulation of autophagy_Homo sapiens_hsa041401.05332305
70Intestinal immune network for IgA production_Homo sapiens_hsa046721.01015238
71Chemical carcinogenesis_Homo sapiens_hsa052041.00597166
72Histidine metabolism_Homo sapiens_hsa003401.00585072
73Pyruvate metabolism_Homo sapiens_hsa006200.97725113
74Estrogen signaling pathway_Homo sapiens_hsa049150.97459150
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92922967
76Alzheimers disease_Homo sapiens_hsa050100.92190708
77Proteasome_Homo sapiens_hsa030500.92059633
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91034313
79cAMP signaling pathway_Homo sapiens_hsa040240.90448139
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.88223925
81Parkinsons disease_Homo sapiens_hsa050120.87968072
82Vitamin digestion and absorption_Homo sapiens_hsa049770.85373193
83Pancreatic secretion_Homo sapiens_hsa049720.84714531
84Glycerolipid metabolism_Homo sapiens_hsa005610.83963511
85Oocyte meiosis_Homo sapiens_hsa041140.81754403
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81399658
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81128512
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.80035809
89ErbB signaling pathway_Homo sapiens_hsa040120.79456462
90Glioma_Homo sapiens_hsa052140.78743301
91Retinol metabolism_Homo sapiens_hsa008300.78470041
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77490396
93One carbon pool by folate_Homo sapiens_hsa006700.76617770
94beta-Alanine metabolism_Homo sapiens_hsa004100.75189814
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74023594
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73060347
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72470174
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71382279
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70837878
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69924010
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68585222
102Metabolic pathways_Homo sapiens_hsa011000.68355607
103ABC transporters_Homo sapiens_hsa020100.68268372
104Primary immunodeficiency_Homo sapiens_hsa053400.65420008
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65240404
106Tight junction_Homo sapiens_hsa045300.63694666
107Steroid biosynthesis_Homo sapiens_hsa001000.63456105
108Ovarian steroidogenesis_Homo sapiens_hsa049130.62182723
109Ribosome_Homo sapiens_hsa030100.61875850
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61724744
111Purine metabolism_Homo sapiens_hsa002300.61576337
112Huntingtons disease_Homo sapiens_hsa050160.61570454
113Nitrogen metabolism_Homo sapiens_hsa009100.61107204
114Glucagon signaling pathway_Homo sapiens_hsa049220.60880021
115Mineral absorption_Homo sapiens_hsa049780.59283395
116Tyrosine metabolism_Homo sapiens_hsa003500.59164546
117Asthma_Homo sapiens_hsa053100.59042258
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58595340
119Bile secretion_Homo sapiens_hsa049760.58221157
120Hedgehog signaling pathway_Homo sapiens_hsa043400.58044285
121Axon guidance_Homo sapiens_hsa043600.57243109
122Type II diabetes mellitus_Homo sapiens_hsa049300.56964998
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56060270
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53999193
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53348370
126Rheumatoid arthritis_Homo sapiens_hsa053230.53294178
127Phagosome_Homo sapiens_hsa041450.53116830
128Ras signaling pathway_Homo sapiens_hsa040140.53115549
129Fatty acid biosynthesis_Homo sapiens_hsa000610.52670267
130Phototransduction_Homo sapiens_hsa047440.52370562
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.51382534
132Rap1 signaling pathway_Homo sapiens_hsa040150.49681536
133Hippo signaling pathway_Homo sapiens_hsa043900.49420433
134Dorso-ventral axis formation_Homo sapiens_hsa043200.49203264
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48795401
136Thyroid cancer_Homo sapiens_hsa052160.48434442
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47976571
138MAPK signaling pathway_Homo sapiens_hsa040100.47783166
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47535984
140Dilated cardiomyopathy_Homo sapiens_hsa054140.47352190
141Melanoma_Homo sapiens_hsa052180.46636910
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.45689308
143VEGF signaling pathway_Homo sapiens_hsa043700.43129553
144Non-homologous end-joining_Homo sapiens_hsa034500.41477772
145Fatty acid degradation_Homo sapiens_hsa000710.41385517
146Pyrimidine metabolism_Homo sapiens_hsa002400.40584845
147Glutathione metabolism_Homo sapiens_hsa004800.40375103
148Renal cell carcinoma_Homo sapiens_hsa052110.39856115
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39515233
150Circadian rhythm_Homo sapiens_hsa047100.39375485
151Sulfur metabolism_Homo sapiens_hsa009200.37604097
152Arginine and proline metabolism_Homo sapiens_hsa003300.37521286
153Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36513640
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36124636
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36111386
156RNA transport_Homo sapiens_hsa030130.35363574
157mTOR signaling pathway_Homo sapiens_hsa041500.35332075
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.34948677
159Arginine biosynthesis_Homo sapiens_hsa002200.34933565
160Choline metabolism in cancer_Homo sapiens_hsa052310.33945386
161Insulin signaling pathway_Homo sapiens_hsa049100.33729993
162Central carbon metabolism in cancer_Homo sapiens_hsa052300.33482967
163Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33061340
164Basal cell carcinoma_Homo sapiens_hsa052170.29800155

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