SLC5A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)9.19827759
2nucleobase catabolic process (GO:0046113)7.22037119
3establishment of nucleus localization (GO:0040023)6.86248662
4neuron projection extension involved in neuron projection guidance (GO:1902284)6.51102934
5axon extension involved in axon guidance (GO:0048846)6.51102934
6cell migration in hindbrain (GO:0021535)5.36697124
7locomotory exploration behavior (GO:0035641)5.28727646
8neuron cell-cell adhesion (GO:0007158)5.08783194
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.02520614
10cranial nerve morphogenesis (GO:0021602)4.97888951
11synaptic vesicle maturation (GO:0016188)4.94328677
12vocalization behavior (GO:0071625)4.78050845
13* neurotransmitter secretion (GO:0007269)4.73620622
14axon extension (GO:0048675)4.65815233
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.57506356
16thyroid gland development (GO:0030878)4.49076740
17retinal ganglion cell axon guidance (GO:0031290)4.47945434
18axon cargo transport (GO:0008088)4.43682356
19urinary tract smooth muscle contraction (GO:0014848)4.43078233
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35337026
21regulation of NFAT protein import into nucleus (GO:0051532)4.35165563
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.33595688
23central nervous system projection neuron axonogenesis (GO:0021952)4.32812872
24neurofilament cytoskeleton organization (GO:0060052)4.30465656
25intermediate filament cytoskeleton organization (GO:0045104)4.22341584
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.21001297
27negative chemotaxis (GO:0050919)4.20527507
28regulation of glutamate receptor signaling pathway (GO:1900449)4.19455897
29synaptic vesicle exocytosis (GO:0016079)4.13523474
30exploration behavior (GO:0035640)4.11545449
31central nervous system neuron axonogenesis (GO:0021955)4.08442479
32peristalsis (GO:0030432)4.08203497
33intermediate filament-based process (GO:0045103)4.07719561
34regulation of synaptic vesicle exocytosis (GO:2000300)4.03924376
35respiratory system process (GO:0003016)3.99626782
36regulation of synapse structural plasticity (GO:0051823)3.96876475
37neuronal action potential propagation (GO:0019227)3.95790900
38prepulse inhibition (GO:0060134)3.95232643
39nucleus localization (GO:0051647)3.94800289
40facial nerve structural organization (GO:0021612)3.91099221
41establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.90309952
42mitochondrion transport along microtubule (GO:0047497)3.90309952
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88712267
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.83385666
45establishment of mitochondrion localization (GO:0051654)3.82745872
46neuron projection extension (GO:1990138)3.81453533
47negative regulation of axon extension (GO:0030517)3.81035945
48ganglion development (GO:0061548)3.80054541
49ionotropic glutamate receptor signaling pathway (GO:0035235)3.76706557
50activation of protein kinase A activity (GO:0034199)3.76124942
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75658592
52positive regulation of fibroblast migration (GO:0010763)3.72647387
53intermediate filament organization (GO:0045109)3.68312141
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.65613745
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.64675344
56startle response (GO:0001964)3.64351643
57negative regulation of axon guidance (GO:1902668)3.62778500
58protein localization to synapse (GO:0035418)3.62559913
59glycine transport (GO:0015816)3.60129715
60regulation of axon guidance (GO:1902667)3.59281647
61regulation of long-term neuronal synaptic plasticity (GO:0048169)3.58765861
62synaptic transmission, dopaminergic (GO:0001963)3.57529132
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.57392678
64neuron recognition (GO:0008038)3.57333669
65neurotransmitter-gated ion channel clustering (GO:0072578)3.56183899
66neuron-neuron synaptic transmission (GO:0007270)3.56031497
67* neurotransmitter transport (GO:0006836)3.54763469
68cranial nerve structural organization (GO:0021604)3.53717743
69regulation of neuronal synaptic plasticity (GO:0048168)3.53374674
70transmission of nerve impulse (GO:0019226)3.52832733
71dendritic spine morphogenesis (GO:0060997)3.52061548
72neuromuscular process controlling posture (GO:0050884)3.51143254
73* regulation of neurotransmitter levels (GO:0001505)3.50876089
74axon regeneration (GO:0031103)3.49927056
75regulation of synaptic vesicle transport (GO:1902803)3.46251695
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.44845367
77regulation of axon extension (GO:0030516)3.42497643
78neuromuscular process controlling balance (GO:0050885)3.40766799
79gamma-aminobutyric acid transport (GO:0015812)3.39964880
80regulation of protein kinase A signaling (GO:0010738)3.35945122
81dendrite morphogenesis (GO:0048813)3.35222856
82glutamate receptor signaling pathway (GO:0007215)3.34333278
83striatum development (GO:0021756)3.33783949
84adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.31468765
85membrane hyperpolarization (GO:0060081)3.30963257
86response to auditory stimulus (GO:0010996)3.30952780
87layer formation in cerebral cortex (GO:0021819)3.28699658
88glutamate secretion (GO:0014047)3.26982288
89neurotransmitter catabolic process (GO:0042135)3.24751603
90synaptic vesicle docking involved in exocytosis (GO:0016081)3.24703752
91motor neuron axon guidance (GO:0008045)3.24167188
92auditory behavior (GO:0031223)3.22591342
93regulation of synaptic transmission, glutamatergic (GO:0051966)3.21177035
94neuronal ion channel clustering (GO:0045161)3.20279401
95axonal fasciculation (GO:0007413)3.20257484
96adult walking behavior (GO:0007628)3.19359969
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.18972545
98proline transport (GO:0015824)3.16787482
99endothelial cell differentiation (GO:0045446)3.16068772
100anterograde axon cargo transport (GO:0008089)3.14300642
101positive regulation of axonogenesis (GO:0050772)3.12979699
102axon development (GO:0061564)3.12941524
103regulation of female receptivity (GO:0045924)3.12880492
104regulation of extent of cell growth (GO:0061387)3.12879920
105negative regulation of axonogenesis (GO:0050771)3.11969302
106regulation of axon extension involved in axon guidance (GO:0048841)3.11475542
107negative regulation of microtubule polymerization (GO:0031115)3.09824628
108presynaptic membrane assembly (GO:0097105)3.09562062
109dopamine receptor signaling pathway (GO:0007212)3.09304217
110negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08293512
111presynaptic membrane organization (GO:0097090)3.08046182
112innervation (GO:0060384)3.07204205
113heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)3.07082916
114postsynaptic membrane organization (GO:0001941)3.06608910
115apical protein localization (GO:0045176)3.06485299
116regulation of chemokine-mediated signaling pathway (GO:0070099)3.05950226
117negative regulation of amino acid transport (GO:0051956)3.05573195
118amino acid import (GO:0043090)3.05329263
119neuromuscular process (GO:0050905)3.04643382
120regulation of respiratory system process (GO:0044065)3.03098812
121synaptic transmission, glutamatergic (GO:0035249)3.02505090
122regulation of axonogenesis (GO:0050770)3.02412502
123lateral sprouting from an epithelium (GO:0060601)3.01831155
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00712324
125mesenchymal-epithelial cell signaling (GO:0060638)3.00437938
126positive regulation of axon extension (GO:0045773)2.99041010
127behavioral response to nicotine (GO:0035095)2.97903609
128regulation of vesicle fusion (GO:0031338)2.96665744
129peripheral nervous system neuron development (GO:0048935)2.95959636
130regulation of dendritic spine morphogenesis (GO:0061001)2.95176838
131regulation of glutamate secretion (GO:0014048)2.94240813
132regulation of neurotransmitter uptake (GO:0051580)2.94172456
133respiratory tube development (GO:0030323)2.93357849
134long-term synaptic potentiation (GO:0060291)2.90665189
135regulation of synaptic transmission, GABAergic (GO:0032228)2.90511119
136regulation of dopamine secretion (GO:0014059)2.89747433
137regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.88562391
138regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.88562391
139positive regulation of neurotransmitter transport (GO:0051590)2.88171816
140behavioral fear response (GO:0001662)2.87561273
141behavioral defense response (GO:0002209)2.87561273
142* neuromuscular synaptic transmission (GO:0007274)2.86654569
143regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85455514
144cAMP catabolic process (GO:0006198)2.84869537
145synapse assembly (GO:0007416)2.83194233
146regulation of postsynaptic membrane potential (GO:0060078)2.81469984
147neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.81365575
148positive regulation of synaptic transmission (GO:0050806)2.81000599
149regulation of respiratory gaseous exchange (GO:0043576)2.80983294
150long-term memory (GO:0007616)2.80389170
151synapse organization (GO:0050808)2.80304516
152positive regulation of membrane potential (GO:0045838)2.78949720
153regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.78305480
154positive regulation of synapse assembly (GO:0051965)2.77837637
155female mating behavior (GO:0060180)2.75036498
156negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74818884
157behavioral response to cocaine (GO:0048148)2.74199139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.15712699
2GBX2_23144817_ChIP-Seq_PC3_Human3.40270903
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23214986
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20947702
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11810259
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.96952194
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.96952194
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83292690
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.82586230
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.75189858
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.70762750
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64512187
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62112649
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50239038
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49204585
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.44564670
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.39806988
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33234958
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29664374
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.29300583
21REST_21632747_ChIP-Seq_MESCs_Mouse2.27000392
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.21838957
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.21631709
24DROSHA_22980978_ChIP-Seq_HELA_Human2.20669281
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.19724275
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.19724275
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.19724275
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10253868
29AR_21572438_ChIP-Seq_LNCaP_Human2.04644522
30TAF15_26573619_Chip-Seq_HEK293_Human2.04564510
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02801249
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94609472
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93691753
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92990183
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.89320827
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82643489
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75046671
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64395480
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63738857
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.61753558
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59242166
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58772886
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54714449
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53952869
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.49958183
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46727186
47OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.45119895
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42133617
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.41140871
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38802410
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.36743099
52P300_19829295_ChIP-Seq_ESCs_Human1.33538465
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31817641
54* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31580368
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31439293
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30484657
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29402825
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29349081
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.27093545
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.25960301
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.25278863
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.24007967
63ZNF274_21170338_ChIP-Seq_K562_Hela1.23915194
64CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22482388
65AR_25329375_ChIP-Seq_VCAP_Human1.20538091
66* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20394482
67RNF2_27304074_Chip-Seq_NSC_Mouse1.19819797
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.19797314
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18997671
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18904428
71AR_19668381_ChIP-Seq_PC3_Human1.16712052
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16385730
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16096584
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15994723
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14202627
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.12770120
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12628413
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11918999
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11161154
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11087389
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10923932
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10163356
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10045250
84STAT3_23295773_ChIP-Seq_U87_Human1.07942412
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.05216144
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04870250
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03656595
88* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03486473
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.03087479
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02913435
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02209916
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01087479
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.01043758
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00950788
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00852606
96AHR_22903824_ChIP-Seq_MCF-7_Human1.00388753
97FUS_26573619_Chip-Seq_HEK293_Human0.99562997
98* RUNX2_22187159_ChIP-Seq_PCA_Human0.99383427
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98751031
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98649437
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98415068
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98359986
103GATA1_26923725_Chip-Seq_HPCs_Mouse0.97448560
104TP53_20018659_ChIP-ChIP_R1E_Mouse0.97339735
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96592724
106IGF1R_20145208_ChIP-Seq_DFB_Human0.94462918
107TCF4_23295773_ChIP-Seq_U87_Human0.94274751
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94050970
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93960620
110ER_23166858_ChIP-Seq_MCF-7_Human0.93237623
111JUN_21703547_ChIP-Seq_K562_Human0.92886722
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92644798
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.92321916
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.92210858
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92112184
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91782213
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91436698
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91436698
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91216303
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91029414
121TP53_18474530_ChIP-ChIP_U2OS_Human0.90930138
122POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90893504
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90803767
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90714139
125TP53_16413492_ChIP-PET_HCT116_Human0.90043289
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.89285537
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.89065745
128SALL1_21062744_ChIP-ChIP_HESCs_Human0.86864440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.69387052
2MP0003880_abnormal_central_pattern4.04355496
3MP0002822_catalepsy3.94082928
4* MP0003635_abnormal_synaptic_transmissio3.69948766
5MP0009745_abnormal_behavioral_response3.30009860
6MP0005423_abnormal_somatic_nervous3.01070512
7MP0002064_seizures2.98397176
8MP0002063_abnormal_learning/memory/cond2.86098678
9MP0009046_muscle_twitch2.68145399
10MP0004142_abnormal_muscle_tone2.67800080
11MP0002272_abnormal_nervous_system2.59248445
12MP0001486_abnormal_startle_reflex2.50766632
13MP0002572_abnormal_emotion/affect_behav2.43435248
14MP0004270_analgesia2.41324721
15MP0001501_abnormal_sleep_pattern2.35340416
16MP0002909_abnormal_adrenal_gland2.29253334
17MP0001529_abnormal_vocalization2.27244962
18MP0002249_abnormal_larynx_morphology2.19461943
19MP0001968_abnormal_touch/_nociception2.18240228
20MP0003122_maternal_imprinting2.09959927
21MP0006276_abnormal_autonomic_nervous1.98088368
22* MP0002184_abnormal_innervation1.97522359
23MP0000013_abnormal_adipose_tissue1.97411711
24MP0001348_abnormal_lacrimal_gland1.92756324
25MP0009780_abnormal_chondrocyte_physiolo1.91012091
26* MP0000955_abnormal_spinal_cord1.87145460
27MP0005409_darkened_coat_color1.86540124
28MP0002751_abnormal_autonomic_nervous1.76862260
29* MP0002734_abnormal_mechanical_nocicepti1.73944286
30MP0002557_abnormal_social/conspecific_i1.69095023
31MP0001440_abnormal_grooming_behavior1.64719880
32MP0005623_abnormal_meninges_morphology1.62379150
33MP0002733_abnormal_thermal_nociception1.61523979
34* MP0001970_abnormal_pain_threshold1.61068328
35MP0002067_abnormal_sensory_capabilities1.58292323
36MP0004782_abnormal_surfactant_physiolog1.57781777
37MP0008438_abnormal_cutaneous_collagen1.57404379
38MP0004811_abnormal_neuron_physiology1.57142940
39MP0005386_behavior/neurological_phenoty1.54305037
40MP0004924_abnormal_behavior1.54305037
41MP0002736_abnormal_nociception_after1.52360452
42MP0008569_lethality_at_weaning1.51522760
43MP0005248_abnormal_Harderian_gland1.51110511
44MP0000778_abnormal_nervous_system1.48933251
45MP0005646_abnormal_pituitary_gland1.44038598
46MP0000569_abnormal_digit_pigmentation1.42134532
47MP0000537_abnormal_urethra_morphology1.40244946
48MP0000579_abnormal_nail_morphology1.40156718
49MP0003787_abnormal_imprinting1.39559469
50MP0003283_abnormal_digestive_organ1.38066375
51* MP0002882_abnormal_neuron_morphology1.33098997
52MP0001177_atelectasis1.31136537
53MP0002932_abnormal_joint_morphology1.30658952
54MP0002066_abnormal_motor_capabilities/c1.29716749
55MP0001299_abnormal_eye_distance/1.29560787
56MP0004885_abnormal_endolymph1.27673608
57MP0002332_abnormal_exercise_endurance1.23811385
58MP0003861_abnormal_nervous_system1.23215773
59MP0003938_abnormal_ear_development1.20785988
60MP0002928_abnormal_bile_duct1.20678267
61MP0001188_hyperpigmentation1.19820593
62MP0003329_amyloid_beta_deposits1.19630031
63MP0001346_abnormal_lacrimal_gland1.17492685
64MP0004858_abnormal_nervous_system1.15158722
65MP0003942_abnormal_urinary_system1.13912250
66MP0003011_delayed_dark_adaptation1.13017150
67MP0003633_abnormal_nervous_system1.12651423
68MP0000751_myopathy1.10364015
69MP0005503_abnormal_tendon_morphology1.10109052
70MP0002114_abnormal_axial_skeleton1.09914621
71MP0002108_abnormal_muscle_morphology1.09904999
72MP0005171_absent_coat_pigmentation1.09041888
73MP0000631_abnormal_neuroendocrine_gland1.08180159
74MP0000681_abnormal_thyroid_gland1.08061549
75MP0003690_abnormal_glial_cell1.07240789
76MP0000534_abnormal_ureter_morphology1.04518597
77* MP0002081_perinatal_lethality1.04240558
78MP0002735_abnormal_chemical_nociception1.03822332
79MP0005645_abnormal_hypothalamus_physiol1.03607536
80MP0000003_abnormal_adipose_tissue1.03106431
81MP0001984_abnormal_olfaction1.02149475
82MP0001905_abnormal_dopamine_level1.01517311
83MP0000538_abnormal_urinary_bladder1.00584819
84MP0000462_abnormal_digestive_system0.99212008
85MP0003385_abnormal_body_wall0.99115860
86MP0010386_abnormal_urinary_bladder0.98872937
87MP0001664_abnormal_digestion0.98457185
88MP0002638_abnormal_pupillary_reflex0.97536727
89MP0003634_abnormal_glial_cell0.96086930
90MP0002102_abnormal_ear_morphology0.95834518
91MP0003879_abnormal_hair_cell0.95744501
92MP0009053_abnormal_anal_canal0.93220202
93MP0003631_nervous_system_phenotype0.90713328
94MP0002152_abnormal_brain_morphology0.89206248
95MP0005187_abnormal_penis_morphology0.89002691
96MP0002876_abnormal_thyroid_physiology0.87723213
97MP0005275_abnormal_skin_tensile0.87575037
98MP0002090_abnormal_vision0.86780023
99MP0002282_abnormal_trachea_morphology0.86604302
100MP0002837_dystrophic_cardiac_calcinosis0.85431965
101* MP0002752_abnormal_somatic_nervous0.85209627
102MP0004085_abnormal_heartbeat0.85144867
103MP0002082_postnatal_lethality0.84841598
104MP0010770_preweaning_lethality0.84841598
105MP0002177_abnormal_outer_ear0.84356066
106MP0005257_abnormal_intraocular_pressure0.82864235
107MP0002069_abnormal_eating/drinking_beha0.82651328
108MP0004742_abnormal_vestibular_system0.82392430
109MP0003119_abnormal_digestive_system0.82087235
110MP0008874_decreased_physiological_sensi0.81487585
111MP0003632_abnormal_nervous_system0.79925432
112MP0000920_abnormal_myelination0.78504509
113MP0004130_abnormal_muscle_cell0.76242876
114MP0004134_abnormal_chest_morphology0.75989860
115MP0004145_abnormal_muscle_electrophysio0.75239290
116MP0002116_abnormal_craniofacial_bone0.75089830
117* MP0001943_abnormal_respiration0.74798826
118MP0010769_abnormal_survival0.74453903
119MP0008004_abnormal_stomach_pH0.71827548
120MP0002127_abnormal_cardiovascular_syste0.71098218
121MP0005551_abnormal_eye_electrophysiolog0.70887605
122MP0002229_neurodegeneration0.70461181
123MP0010768_mortality/aging0.70431845
124MP0000026_abnormal_inner_ear0.70176907
125MP0000467_abnormal_esophagus_morphology0.69046344
126MP0001502_abnormal_circadian_rhythm0.67853228
127MP0005535_abnormal_body_temperature0.67704887
128MP0004233_abnormal_muscle_weight0.67362467
129MP0003121_genomic_imprinting0.66984026
130MP0009250_abnormal_appendicular_skeleto0.66360884
131MP0008961_abnormal_basal_metabolism0.61587682
132MP0001963_abnormal_hearing_physiology0.61285461
133MP0004272_abnormal_basement_membrane0.60407722
134MP0008872_abnormal_physiological_respon0.59440442
135MP0005499_abnormal_olfactory_system0.59194207
136MP0005394_taste/olfaction_phenotype0.59194207
137MP0004215_abnormal_myocardial_fiber0.59021839
138MP0001958_emphysema0.58227201
139MP0003123_paternal_imprinting0.57775429

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.62652647
2Ulnar claw (HP:0001178)6.10470305
3Focal motor seizures (HP:0011153)5.69345925
4Focal seizures (HP:0007359)5.03670988
5Atonic seizures (HP:0010819)4.40045375
6Aqueductal stenosis (HP:0002410)4.33711726
7Segmental peripheral demyelination/remyelination (HP:0003481)4.03377184
8Febrile seizures (HP:0002373)3.65577776
9Partial agenesis of the corpus callosum (HP:0001338)3.55317517
10Supranuclear gaze palsy (HP:0000605)3.51880755
11Cortical dysplasia (HP:0002539)3.49340149
12Morphological abnormality of the pyramidal tract (HP:0002062)3.43773653
13Poor suck (HP:0002033)3.35504238
14Torticollis (HP:0000473)3.32119851
15Abnormal eating behavior (HP:0100738)3.24875674
16Abnormality of the musculature of the hand (HP:0001421)3.20515910
17Generalized hypotonia (HP:0001290)3.16798988
18Pheochromocytoma (HP:0002666)3.16500157
19Progressive cerebellar ataxia (HP:0002073)3.15894843
20Epileptic encephalopathy (HP:0200134)3.15794010
21Generalized tonic-clonic seizures (HP:0002069)3.13782001
22Ankle clonus (HP:0011448)3.09690987
23Action tremor (HP:0002345)3.08785529
24Absence seizures (HP:0002121)3.06886090
25Dysdiadochokinesis (HP:0002075)3.04820386
26Absent septum pellucidum (HP:0001331)2.97497147
27Neurofibrillary tangles (HP:0002185)2.97463251
28Pachygyria (HP:0001302)2.97156145
29Aplasia/Hypoplasia of the brainstem (HP:0007362)2.95362152
30Hypoplasia of the brainstem (HP:0002365)2.95362152
31Anxiety (HP:0000739)2.90221499
32Visual hallucinations (HP:0002367)2.83492336
33Steppage gait (HP:0003376)2.82851067
34Resting tremor (HP:0002322)2.77685253
35Dialeptic seizures (HP:0011146)2.77164385
36Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.76292535
37Amyotrophic lateral sclerosis (HP:0007354)2.75136471
38Craniofacial dystonia (HP:0012179)2.72540394
39Hypoventilation (HP:0002791)2.72339066
40Abnormality of the septum pellucidum (HP:0007375)2.72012486
41Neuroendocrine neoplasm (HP:0100634)2.71793119
42Gait imbalance (HP:0002141)2.68748916
43Focal dystonia (HP:0004373)2.67940835
44Onion bulb formation (HP:0003383)2.63794864
45Hyperventilation (HP:0002883)2.62430699
46Decreased motor nerve conduction velocity (HP:0003431)2.60880827
47Lissencephaly (HP:0001339)2.58228962
48Depression (HP:0000716)2.57576429
49Microglossia (HP:0000171)2.51912171
50Hyperthyroidism (HP:0000836)2.49705053
51Amblyopia (HP:0000646)2.48803077
52Mutism (HP:0002300)2.47922271
53Abnormality of the foot musculature (HP:0001436)2.46045801
54Polyphagia (HP:0002591)2.46008744
55Impaired vibration sensation in the lower limbs (HP:0002166)2.45507270
56Limb dystonia (HP:0002451)2.45223742
57Failure to thrive in infancy (HP:0001531)2.44700486
58Broad-based gait (HP:0002136)2.44229011
59Urinary urgency (HP:0000012)2.43265744
60Foot dorsiflexor weakness (HP:0009027)2.41959503
61Impaired social interactions (HP:0000735)2.40656728
62Abnormal social behavior (HP:0012433)2.40656728
63Oligomenorrhea (HP:0000876)2.39688604
64Premature rupture of membranes (HP:0001788)2.39251543
65Adducted thumb (HP:0001181)2.38598608
66Dysmetria (HP:0001310)2.38240818
67Neoplasm of the peripheral nervous system (HP:0100007)2.36879590
68Postural instability (HP:0002172)2.29539268
69Cerebral inclusion bodies (HP:0100314)2.29180598
70Exotropia (HP:0000577)2.29085285
71Abnormality of salivation (HP:0100755)2.26148771
72Poor eye contact (HP:0000817)2.24829378
73Spastic paraplegia (HP:0001258)2.19556263
74Increased variability in muscle fiber diameter (HP:0003557)2.19113612
75Paraplegia (HP:0010550)2.18210898
76Buphthalmos (HP:0000557)2.16829647
77Protrusio acetabuli (HP:0003179)2.16625549
78Lower limb amyotrophy (HP:0007210)2.13488029
79Hypercortisolism (HP:0001578)2.11910436
80Spastic gait (HP:0002064)2.11220785
81Excessive salivation (HP:0003781)2.10506802
82Drooling (HP:0002307)2.10506802
83Akinesia (HP:0002304)2.08125196
84Insidious onset (HP:0003587)2.07197688
85Termporal pattern (HP:0011008)2.07197688
86Intention tremor (HP:0002080)2.05965002
87Truncal ataxia (HP:0002078)2.05904437
88Abnormality of the lower motor neuron (HP:0002366)2.05005703
89Urinary bladder sphincter dysfunction (HP:0002839)2.04237889
90Sacral dimple (HP:0000960)2.04116380
91Morphological abnormality of the middle ear (HP:0008609)2.03208397
92Ankyloglossia (HP:0010296)2.02563463
93Narrow nasal bridge (HP:0000446)2.02078783
94EEG with generalized epileptiform discharges (HP:0011198)1.99700109
95Abnormality of the corticospinal tract (HP:0002492)1.99306724
96Hypsarrhythmia (HP:0002521)1.99266336
97Epileptiform EEG discharges (HP:0011182)1.98203552
98Absent speech (HP:0001344)1.95663389
99Myelomeningocele (HP:0002475)1.95372280
100Inappropriate behavior (HP:0000719)1.95367343
101Papilledema (HP:0001085)1.93944144
102Pointed chin (HP:0000307)1.93256037
103Hemiplegia (HP:0002301)1.92482799
104Lower limb muscle weakness (HP:0007340)1.92145247
105Spastic tetraplegia (HP:0002510)1.90390385
106Macroorchidism (HP:0000053)1.89954495
107Hammertoe (HP:0001765)1.89909357
108Scanning speech (HP:0002168)1.89808737
109Abnormality of pain sensation (HP:0010832)1.89471734
110Impaired pain sensation (HP:0007328)1.89471734
111Genetic anticipation (HP:0003743)1.88434272
112Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.86109986
113Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83834197
114Degeneration of the lateral corticospinal tracts (HP:0002314)1.83834197
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83214604
116Midline defect of the nose (HP:0004122)1.83010398
117Abnormality of the calcaneus (HP:0008364)1.82857201
118Gaze-evoked nystagmus (HP:0000640)1.82382070
119Apathy (HP:0000741)1.81210824
120Annular pancreas (HP:0001734)1.80471996
121Bradykinesia (HP:0002067)1.78697911
122Incomplete penetrance (HP:0003829)1.78594657
123Agitation (HP:0000713)1.75906930
124Hyperacusis (HP:0010780)1.75380044
125Abnormality of binocular vision (HP:0011514)1.75303924
126Diplopia (HP:0000651)1.75303924
127Spastic tetraparesis (HP:0001285)1.75055161
128Delayed gross motor development (HP:0002194)1.74626863
129Postural tremor (HP:0002174)1.74411148
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74155572
131Septo-optic dysplasia (HP:0100842)1.73915120
132Hypoplasia of the corpus callosum (HP:0002079)1.73771393
133Blue irides (HP:0000635)1.73418603
134Fetal akinesia sequence (HP:0001989)1.72226562
135Ventricular fibrillation (HP:0001663)1.72036409
136Bladder diverticulum (HP:0000015)1.71944965
137Bowel diverticulosis (HP:0005222)1.71913760
138Distal sensory impairment (HP:0002936)1.71855412
139Megalencephaly (HP:0001355)1.70867172
140Striae distensae (HP:0001065)1.70751115
141Prolonged QT interval (HP:0001657)1.69634096
142Abnormal EKG (HP:0003115)1.68897698
143Polymicrogyria (HP:0002126)1.68545294
144Vaginal atresia (HP:0000148)1.67945200
145Aplasia involving bones of the extremities (HP:0009825)1.67553219
146Aplasia involving bones of the upper limbs (HP:0009823)1.67553219
147Aplasia of the phalanges of the hand (HP:0009802)1.67553219
148Overgrowth (HP:0001548)1.67508857
149Gait ataxia (HP:0002066)1.63404164
150Clonus (HP:0002169)1.63194695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.89008381
2NTRK33.86100169
3EPHA43.83381372
4MINK13.60258886
5CASK3.12546714
6DYRK22.90247948
7FES2.87532499
8TYRO32.84942225
9MAP3K42.71558457
10MAP3K92.55331373
11MAP3K122.36515801
12NTRK22.03765890
13MAP2K72.03620120
14TRIM281.87007349
15MAP2K41.80247024
16TNIK1.65337687
17MAPK131.60088617
18BCR1.60054332
19NTRK11.54885190
20PAK61.52112238
21PRKCG1.51676357
22CAMKK11.47398716
23SIK21.46356185
24KSR21.45719215
25LIMK11.44170205
26CDK51.35778714
27LMTK21.28432942
28PRKD31.26120179
29LATS21.26037313
30PHKG21.25145656
31PHKG11.25145656
32UHMK11.24805369
33DAPK21.24262575
34WNK11.23774245
35PAK31.22560573
36STK381.17995847
37GRK51.14491781
38PRKCE1.13642660
39DDR21.11011248
40PLK21.08669857
41CAMK2A1.08416855
42PRKCH1.07586129
43CAMK1G1.07329956
44TNK21.01679511
45KSR10.97347554
46DYRK1A0.96391061
47MAP3K20.94274789
48CAMK2G0.93877556
49SGK2230.93033590
50SGK4940.93033590
51MKNK20.92900752
52RET0.87866995
53IRAK20.84393784
54PINK10.83467590
55PDGFRA0.81770635
56MAP3K60.81526113
57GRK70.81457541
58ADRBK10.80681074
59CDK140.78724869
60BMPR1B0.78245257
61FER0.77891604
62PRKCZ0.76954326
63ROCK10.76784822
64MAP2K10.74351107
65MARK20.74150382
66NEK10.73765631
67TAF10.72911073
68ALK0.72300432
69PDGFRB0.68636264
70CSF1R0.67492915
71SGK20.67459089
72ERBB30.67081399
73MAPK150.66744146
74DAPK10.66692698
75CDK150.66666708
76EPHB20.66504186
77SGK30.65803460
78CDK180.65533739
79WNK30.65356173
80MKNK10.64890325
81CAMK2B0.64657540
82CDC42BPA0.64405203
83FGFR20.63238219
84FYN0.63224272
85CSNK1E0.62642271
86PNCK0.60801961
87ROCK20.60088206
88CAMKK20.59618640
89STK240.58306728
90CSNK1A1L0.57303982
91INSRR0.56743025
92RPS6KA30.54758359
93STK110.53900041
94MAPK40.53745095
95RIPK40.53733259
96CAMK2D0.53592049
97CDK11A0.53032698
98CSNK1G30.52729780
99TGFBR10.52293214
100IRAK10.52163702
101ADRBK20.51928693
102AKT30.50915499
103CSNK1G20.50304052
104SIK10.49806354
105SGK10.48586350
106PRKCB0.47628812
107PASK0.47188842
108CAMK10.46624125
109TRIB30.46245953
110RPS6KB10.46168092
111ERBB20.45729833
112SIK30.44939731
113CDK190.44528224
114MAPK90.43871938
115CSNK1G10.43693208
116TAOK10.42876060
117EEF2K0.42430711
118MAPK100.41705948
119FRK0.40050538
120PDPK10.39993569
121SCYL20.39437501
122SRC0.38168293
123RPS6KA20.38144834
124PKN10.37773665
125EIF2AK20.37169337
126ICK0.36416022
127PRKACB0.36193398
128MAPK80.35908303
129INSR0.35312315
130PIK3CA0.34873961
131EPHA30.34547678
132PRKACA0.34532226
133DYRK1B0.34406660
134PRKG10.32363927
135MAP3K50.31558149
136ILK0.30868070
137CAMK1D0.30599328
138RIPK10.30559502
139TESK10.28846054
140PRKAA10.28830849
141NME10.27990168
142PRKDC0.27955508
143CSNK1D0.25104774
144GSK3B0.22662068

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.33863364
2Nicotine addiction_Homo sapiens_hsa050332.96782931
3Olfactory transduction_Homo sapiens_hsa047402.71475024
4GABAergic synapse_Homo sapiens_hsa047272.57198440
5Morphine addiction_Homo sapiens_hsa050322.36564495
6Circadian entrainment_Homo sapiens_hsa047132.28293966
7* Cholinergic synapse_Homo sapiens_hsa047252.23133647
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15171308
9Glutamatergic synapse_Homo sapiens_hsa047242.08494565
10Dopaminergic synapse_Homo sapiens_hsa047281.99867047
11Long-term potentiation_Homo sapiens_hsa047201.97690500
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.95395405
13Amphetamine addiction_Homo sapiens_hsa050311.93364071
14Cocaine addiction_Homo sapiens_hsa050301.90791129
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84514577
16Salivary secretion_Homo sapiens_hsa049701.81026427
17Renin secretion_Homo sapiens_hsa049241.75262538
18Long-term depression_Homo sapiens_hsa047301.63575398
19Gap junction_Homo sapiens_hsa045401.59759908
20Gastric acid secretion_Homo sapiens_hsa049711.58009884
21Insulin secretion_Homo sapiens_hsa049111.54560222
22Serotonergic synapse_Homo sapiens_hsa047261.52086516
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50355594
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50246822
25Collecting duct acid secretion_Homo sapiens_hsa049661.49570358
26Steroid biosynthesis_Homo sapiens_hsa001001.49035486
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41729202
28Calcium signaling pathway_Homo sapiens_hsa040201.38861892
29Oxytocin signaling pathway_Homo sapiens_hsa049211.30367152
30Taste transduction_Homo sapiens_hsa047421.30246581
31Hedgehog signaling pathway_Homo sapiens_hsa043401.29430622
32Nitrogen metabolism_Homo sapiens_hsa009101.26698833
33Axon guidance_Homo sapiens_hsa043601.26492864
34Prolactin signaling pathway_Homo sapiens_hsa049171.24302246
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20337836
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19742436
37GnRH signaling pathway_Homo sapiens_hsa049121.19629262
38Cardiac muscle contraction_Homo sapiens_hsa042601.19544428
39Vibrio cholerae infection_Homo sapiens_hsa051101.19153305
40Parkinsons disease_Homo sapiens_hsa050121.18063904
41cAMP signaling pathway_Homo sapiens_hsa040241.16868082
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16427555
43Oxidative phosphorylation_Homo sapiens_hsa001901.15468682
44Fatty acid biosynthesis_Homo sapiens_hsa000611.13419389
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08473502
46Glioma_Homo sapiens_hsa052141.06163832
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04421022
48Endometrial cancer_Homo sapiens_hsa052131.03392077
49Colorectal cancer_Homo sapiens_hsa052101.02503823
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99877525
51Dilated cardiomyopathy_Homo sapiens_hsa054140.99550035
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.99065938
53Alzheimers disease_Homo sapiens_hsa050100.99037183
54Type II diabetes mellitus_Homo sapiens_hsa049300.95104461
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94599062
56Estrogen signaling pathway_Homo sapiens_hsa049150.93237647
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.92551698
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92172256
59Prion diseases_Homo sapiens_hsa050200.91963083
60Phototransduction_Homo sapiens_hsa047440.90702978
61Butanoate metabolism_Homo sapiens_hsa006500.90490337
62Hippo signaling pathway_Homo sapiens_hsa043900.89471579
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89150022
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.87984986
65VEGF signaling pathway_Homo sapiens_hsa043700.86395628
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85378052
67Melanogenesis_Homo sapiens_hsa049160.84307388
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84109423
69ErbB signaling pathway_Homo sapiens_hsa040120.77506183
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73512205
71Tight junction_Homo sapiens_hsa045300.72852936
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72771525
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72496525
74Ether lipid metabolism_Homo sapiens_hsa005650.72138441
75Rap1 signaling pathway_Homo sapiens_hsa040150.68466086
76Thyroid hormone synthesis_Homo sapiens_hsa049180.68367210
77Oocyte meiosis_Homo sapiens_hsa041140.67665954
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67341228
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65567400
80Ovarian steroidogenesis_Homo sapiens_hsa049130.65450199
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65408092
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64644031
83Basal cell carcinoma_Homo sapiens_hsa052170.64205396
84Huntingtons disease_Homo sapiens_hsa050160.61620943
85AMPK signaling pathway_Homo sapiens_hsa041520.59567839
86Ras signaling pathway_Homo sapiens_hsa040140.58916280
87Dorso-ventral axis formation_Homo sapiens_hsa043200.58743628
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58588068
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58075531
90Melanoma_Homo sapiens_hsa052180.57219376
91Alcoholism_Homo sapiens_hsa050340.56867272
92Chronic myeloid leukemia_Homo sapiens_hsa052200.56543874
93Type I diabetes mellitus_Homo sapiens_hsa049400.55919138
94mTOR signaling pathway_Homo sapiens_hsa041500.55346347
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55203913
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55049752
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54558981
98* Choline metabolism in cancer_Homo sapiens_hsa052310.54443112
99Circadian rhythm_Homo sapiens_hsa047100.54259835
100TGF-beta signaling pathway_Homo sapiens_hsa043500.53895966
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53583328
102Phagosome_Homo sapiens_hsa041450.53176219
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50566063
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50102381
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.49865921
106Renal cell carcinoma_Homo sapiens_hsa052110.48712328
107MAPK signaling pathway_Homo sapiens_hsa040100.48577456
108Focal adhesion_Homo sapiens_hsa045100.48189888
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48092005
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.47701537
111Pancreatic secretion_Homo sapiens_hsa049720.47162287
112Platelet activation_Homo sapiens_hsa046110.46820418
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46254707
114Glucagon signaling pathway_Homo sapiens_hsa049220.45901258
115Insulin signaling pathway_Homo sapiens_hsa049100.45868288
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45807554
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45159919
118mRNA surveillance pathway_Homo sapiens_hsa030150.45014269
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44449725
120Endocytosis_Homo sapiens_hsa041440.41215917
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38865281
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38334906
123ECM-receptor interaction_Homo sapiens_hsa045120.37701299
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36841958
125Bile secretion_Homo sapiens_hsa049760.36521192
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36402439
127Wnt signaling pathway_Homo sapiens_hsa043100.35007656

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