SLC5A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.49483112
2thyroid hormone generation (GO:0006590)9.34229046
3epithelial cilium movement (GO:0003351)9.01708849
4drug transmembrane transport (GO:0006855)8.74382393
5motile cilium assembly (GO:0044458)8.47040881
6urate metabolic process (GO:0046415)8.43164326
7thyroid hormone metabolic process (GO:0042403)8.13841508
8axoneme assembly (GO:0035082)7.71046628
9drug transport (GO:0015893)7.48409522
10aminoglycoside antibiotic metabolic process (GO:0030647)7.27933816
11phosphate ion transport (GO:0006817)6.79777303
12organic cation transport (GO:0015695)6.51040667
13drug catabolic process (GO:0042737)6.42542714
14exogenous drug catabolic process (GO:0042738)6.06885191
15lysine metabolic process (GO:0006553)6.05877801
16lysine catabolic process (GO:0006554)6.05877801
17phosphate ion transmembrane transport (GO:0035435)5.99060364
18vitamin transmembrane transport (GO:0035461)5.81192821
19diterpenoid biosynthetic process (GO:0016102)5.66272524
20one-carbon compound transport (GO:0019755)5.50361511
21quaternary ammonium group transport (GO:0015697)5.39951674
22excretion (GO:0007588)5.33896317
23primary alcohol catabolic process (GO:0034310)5.29876896
24cysteine metabolic process (GO:0006534)5.20844230
25renal absorption (GO:0070293)5.20168203
26ethanol metabolic process (GO:0006067)5.05758927
27nonribosomal peptide biosynthetic process (GO:0019184)4.93957455
28left/right axis specification (GO:0070986)4.87359131
29vitamin D metabolic process (GO:0042359)4.74587475
30modified amino acid transport (GO:0072337)4.69615499
31left/right pattern formation (GO:0060972)4.62781109
32short-chain fatty acid metabolic process (GO:0046459)4.59448453
33glutathione biosynthetic process (GO:0006750)4.48927534
34regulation of cilium movement (GO:0003352)4.48263728
35negative regulation of T cell differentiation in thymus (GO:0033085)4.45878067
36glyoxylate metabolic process (GO:0046487)4.43642726
37homocysteine metabolic process (GO:0050667)4.42213543
38phosphate ion homeostasis (GO:0055062)4.41461253
39trivalent inorganic anion homeostasis (GO:0072506)4.41461253
40toxin transport (GO:1901998)4.40434920
41ventricular system development (GO:0021591)4.39682105
42response to mercury ion (GO:0046689)4.35588015
43carnitine transport (GO:0015879)4.24995834
44amino-acid betaine transport (GO:0015838)4.24995834
45microtubule bundle formation (GO:0001578)4.24866076
46peptide catabolic process (GO:0043171)4.23773557
47cilium organization (GO:0044782)4.15631322
48tricarboxylic acid metabolic process (GO:0072350)4.08693904
49sulfur compound transport (GO:0072348)4.05469037
50sulfate transmembrane transport (GO:1902358)4.01928726
51cilium assembly (GO:0042384)3.98267477
52pyrimidine-containing compound transmembrane transport (GO:0072531)3.94224774
53intraciliary transport (GO:0042073)3.90974584
54glucuronate metabolic process (GO:0019585)3.90309154
55uronic acid metabolic process (GO:0006063)3.90309154
56ethanol oxidation (GO:0006069)3.86602351
57bundle of His cell to Purkinje myocyte communication (GO:0086069)3.83385664
58terpenoid biosynthetic process (GO:0016114)3.82687357
59fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.79413454
60regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.77287986
61aspartate family amino acid catabolic process (GO:0009068)3.76808551
62amino-acid betaine metabolic process (GO:0006577)3.75943019
63negative regulation of humoral immune response (GO:0002921)3.72573875
64branched-chain amino acid metabolic process (GO:0009081)3.71193763
65carnitine metabolic process (GO:0009437)3.70688030
66fatty acid beta-oxidation (GO:0006635)3.67990801
67sulfur amino acid catabolic process (GO:0000098)3.67982732
68cellular glucuronidation (GO:0052695)3.66022383
69valine metabolic process (GO:0006573)3.63954495
70peptide biosynthetic process (GO:0043043)3.63800514
71metanephric nephron tubule development (GO:0072234)3.60822408
72metanephric tubule development (GO:0072170)3.60822408
73calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.53377643
74glomerular epithelial cell development (GO:0072310)3.53316173
75glycoside metabolic process (GO:0016137)3.53182111
76protein localization to cilium (GO:0061512)3.52745363
77response to phenylpropanoid (GO:0080184)3.51757090
78flavonoid metabolic process (GO:0009812)3.50419444
79retinoic acid metabolic process (GO:0042573)3.48660658
80regulation of bile acid biosynthetic process (GO:0070857)3.48429537
81vitamin transport (GO:0051180)3.48244299
82nephron tubule formation (GO:0072079)3.46456322
83fatty acid oxidation (GO:0019395)3.43723183
84fructose metabolic process (GO:0006000)3.42895060
85cellular modified amino acid catabolic process (GO:0042219)3.41385785
86thyroid gland development (GO:0030878)3.40733538
87multicellular organismal water homeostasis (GO:0050891)3.38001807
88lipid oxidation (GO:0034440)3.36560505
89beta-amyloid metabolic process (GO:0050435)3.34198468
90response to growth hormone (GO:0060416)3.33362020
91cellular response to vitamin D (GO:0071305)3.31589230
92transepithelial transport (GO:0070633)3.31053715
93desmosome organization (GO:0002934)3.31048253
94intestinal epithelial cell development (GO:0060576)3.30367810
95metanephric nephron epithelium development (GO:0072243)3.29937242
96positive regulation of digestive system process (GO:0060456)3.29476832
97cellular component assembly involved in morphogenesis (GO:0010927)3.28974035
98retinol metabolic process (GO:0042572)3.27401366
99response to xenobiotic stimulus (GO:0009410)3.25542670
100purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.25430011
1013-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.25430011
102UDP-N-acetylglucosamine metabolic process (GO:0006047)3.24884135
103oligosaccharide catabolic process (GO:0009313)3.23073170
104nephron tubule development (GO:0072080)3.22646330
105indole-containing compound catabolic process (GO:0042436)3.21332119
106indolalkylamine catabolic process (GO:0046218)3.21332119
107tryptophan catabolic process (GO:0006569)3.21332119
108regulation of cholesterol homeostasis (GO:2000188)3.20377163
109glutathione metabolic process (GO:0006749)3.20318087
110polyol transport (GO:0015791)3.19682474
111cellular ketone body metabolic process (GO:0046950)3.19037045
112sulfate transport (GO:0008272)3.18595597
113negative regulation of B cell mediated immunity (GO:0002713)3.17596166
114negative regulation of immunoglobulin mediated immune response (GO:0002890)3.17596166
115sodium-independent organic anion transport (GO:0043252)3.17474594
116hemidesmosome assembly (GO:0031581)3.16652020
117benzene-containing compound metabolic process (GO:0042537)3.15334968
118primary alcohol metabolic process (GO:0034308)3.13871959
119regulation of apoptotic process involved in morphogenesis (GO:1902337)3.12477746
120actin filament depolymerization (GO:0030042)3.10641440
1212-oxoglutarate metabolic process (GO:0006103)3.10526420
122keratinocyte development (GO:0003334)3.07996590
123O-glycan processing (GO:0016266)3.07761716
124aromatic amino acid family catabolic process (GO:0009074)3.07464286
125cilium morphogenesis (GO:0060271)3.07096628
126tryptophan metabolic process (GO:0006568)3.06042696
127hydrogen peroxide catabolic process (GO:0042744)3.05536763
128intestinal absorption (GO:0050892)3.04413077
129arginine catabolic process (GO:0006527)3.04356849
130acetyl-CoA metabolic process (GO:0006084)3.04271148
131negative regulation of JUN kinase activity (GO:0043508)3.04261523
132glutathione derivative metabolic process (GO:1901685)3.03771166
133glutathione derivative biosynthetic process (GO:1901687)3.03771166
134centriole assembly (GO:0098534)3.03424672
135erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00796375
136L-phenylalanine metabolic process (GO:0006558)3.00796375
137fatty acid catabolic process (GO:0009062)3.00518192
138lateral ventricle development (GO:0021670)3.00038214
139water homeostasis (GO:0030104)2.99907082
140branched-chain amino acid catabolic process (GO:0009083)2.99654054
141serine family amino acid metabolic process (GO:0009069)2.97383212
142metanephric epithelium development (GO:0072207)2.97376312
143drug metabolic process (GO:0017144)2.96510373
144proline metabolic process (GO:0006560)2.95153316
145cell projection assembly (GO:0030031)2.94971034
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.94603940
147L-phenylalanine catabolic process (GO:0006559)2.91766447
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91766447
149neurotransmitter biosynthetic process (GO:0042136)2.91301067
150regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.91032624
151phosphatidylethanolamine biosynthetic process (GO:0006646)2.90813963
152regulation of germinal center formation (GO:0002634)2.85971045
153photoreceptor cell maintenance (GO:0045494)2.81134978
154microtubule-based movement (GO:0007018)2.79358624
155nitric oxide biosynthetic process (GO:0006809)2.77175092
156regulation of apoptotic cell clearance (GO:2000425)2.75104408
157hormone biosynthetic process (GO:0042446)2.75077877
158phosphatidylethanolamine metabolic process (GO:0046337)2.74908664
159oligosaccharide biosynthetic process (GO:0009312)2.74766769
160regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.74704524
161regulation of microtubule-based movement (GO:0060632)2.74447396
162regulation of interleukin-5 production (GO:0032674)2.73146159
163L-ascorbic acid metabolic process (GO:0019852)2.71063185
164regulation of collateral sprouting (GO:0048670)2.70006975
165polyol catabolic process (GO:0046174)2.63203155
166long-chain fatty acid biosynthetic process (GO:0042759)2.63038255
167sperm motility (GO:0030317)2.59504058
168iron ion import (GO:0097286)2.56937968
169regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.54560998
170intra-S DNA damage checkpoint (GO:0031573)2.53549323
171lung epithelium development (GO:0060428)2.50526090
172cytoplasmic microtubule organization (GO:0031122)2.47204161
173retinal metabolic process (GO:0042574)2.44096267
174phenol-containing compound catabolic process (GO:0019336)2.41407659
175regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.39161995
176sphingomyelin metabolic process (GO:0006684)2.38752653
177tolerance induction (GO:0002507)2.36716554
178hydrogen peroxide metabolic process (GO:0042743)2.35474198
179regulation of guanylate cyclase activity (GO:0031282)2.35362093
180axonemal dynein complex assembly (GO:0070286)13.1279442
181cilium or flagellum-dependent cell motility (GO:0001539)12.4824669
182cilium movement (GO:0003341)10.7603200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.63507541
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.53842097
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.32776702
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.27207234
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.21988710
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.02919810
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.97646914
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.88322083
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77499431
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.60963106
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.51179550
12STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.38693591
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35991289
14GATA4_25053715_ChIP-Seq_YYC3_Human2.25077939
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19141994
16SOX2_20726797_ChIP-Seq_SW620_Human2.14499285
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10690717
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09885207
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02734555
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99497742
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96836707
22GATA6_25053715_ChIP-Seq_YYC3_Human1.95868555
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.95719478
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91306847
25ER_23166858_ChIP-Seq_MCF-7_Human1.87006805
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86430256
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85411050
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83742847
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80631113
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80192874
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77828624
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75693333
33ZNF274_21170338_ChIP-Seq_K562_Hela1.71597148
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70648852
35CLOCK_20551151_ChIP-Seq_293T_Human1.68696621
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65486028
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65389122
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62094586
39SMAD4_21799915_ChIP-Seq_A2780_Human1.59601879
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.58367421
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57916431
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56946049
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55386629
44GBX2_23144817_ChIP-Seq_PC3_Human1.54422181
45VDR_22108803_ChIP-Seq_LS180_Human1.53735187
46* RACK7_27058665_Chip-Seq_MCF-7_Human1.53303517
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.51330911
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50421547
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.49961957
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47551316
51STAT3_23295773_ChIP-Seq_U87_Human1.45715397
52* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44782958
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39732542
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39506973
55AR_21572438_ChIP-Seq_LNCaP_Human1.38529097
56TP53_18474530_ChIP-ChIP_U2OS_Human1.38376868
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38141141
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36445261
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36104570
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33970791
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32906327
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31028056
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30880129
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30853314
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30740389
66* AR_25329375_ChIP-Seq_VCAP_Human1.30496228
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29826529
68FUS_26573619_Chip-Seq_HEK293_Human1.29450325
69P300_19829295_ChIP-Seq_ESCs_Human1.29238744
70KLF5_25053715_ChIP-Seq_YYC3_Human1.27510847
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27262989
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26392042
73ZNF263_19887448_ChIP-Seq_K562_Human1.25807924
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25755058
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.25546619
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.25505284
77* TCF4_22108803_ChIP-Seq_LS180_Human1.25230711
78TCF4_23295773_ChIP-Seq_U87_Human1.24522959
79AHR_22903824_ChIP-Seq_MCF-7_Human1.23870195
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.23704712
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22100353
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22028913
83CBP_20019798_ChIP-Seq_JUKART_Human1.22028913
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21125098
85* AR_21909140_ChIP-Seq_LNCAP_Human1.20927325
86TP53_16413492_ChIP-PET_HCT116_Human1.19485371
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17705384
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.17461179
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.17176594
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17062741
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16893143
92TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15916489
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.15238486
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15030326
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14391758
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.14178929
97TAF15_26573619_Chip-Seq_HEK293_Human1.13914580
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13232313
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.13190580
100HNF4A_19822575_ChIP-Seq_HepG2_Human1.12934018
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12664961
102ETV1_20927104_ChIP-Seq_GIST48_Human1.12561281
103PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12407033
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12102792
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.12070912
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.09341969
107P53_22387025_ChIP-Seq_ESCs_Mouse1.09165867
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09089934
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09089934
110RUNX2_22187159_ChIP-Seq_PCA_Human1.08844053
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08410448
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08410448
113* PRDM14_20953172_ChIP-Seq_ESCs_Human1.07566906
114TP63_23658742_ChIP-Seq_EP156T_Human1.07512186
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07382337
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07012966
117RXR_22108803_ChIP-Seq_LS180_Human1.05584922
118HOXB7_26014856_ChIP-Seq_BT474_Human1.05126924
119CDX2_22108803_ChIP-Seq_LS180_Human1.04471423
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.04197580
121GATA3_24758297_ChIP-Seq_MCF-7_Human1.04141542
122* PIAS1_25552417_ChIP-Seq_VCAP_Human1.03764502
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.03373142
124EGR1_19032775_ChIP-ChIP_M12_Human1.03199672
125ATF3_27146783_Chip-Seq_COLON_Human1.03000775
126EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02797929
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.01680141
128FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00788309
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00775928
130SMAD_19615063_ChIP-ChIP_OVARY_Human1.00455398
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99733078
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98615842
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98384230
134TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98127363
135CJUN_26792858_Chip-Seq_BT549_Human0.97496077
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97338620
137GATA2_19941826_ChIP-Seq_K562_Human0.96540281
138DROSHA_22980978_ChIP-Seq_HELA_Human0.95686868
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94993274
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.94563665
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93717247
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92342081
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92342081
144LXR_22292898_ChIP-Seq_THP-1_Human0.92093489
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87744546
146* TBX20_22080862_ChIP-Seq_HEART_Mouse0.86742292
147* TBX20_22328084_ChIP-Seq_HEART_Mouse0.86742292
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.86512558
149TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84458492
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84448420
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84425404
152VDR_24787735_ChIP-Seq_THP-1_Human0.84106205
153EP300_21415370_ChIP-Seq_HL-1_Mouse0.82454831
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80441494
155ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79422870
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.79334027
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77678055
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.76073269
159BCAT_22108803_ChIP-Seq_LS180_Human0.73099439
160GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73037139
161WT1_25993318_ChIP-Seq_PODOCYTE_Human0.72913351
162ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.72553152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.94177253
2MP0010234_abnormal_vibrissa_follicle4.90543256
3MP0004043_abnormal_pH_regulation4.74648682
4MP0004019_abnormal_vitamin_homeostasis4.02122924
5MP0003878_abnormal_ear_physiology3.81044390
6MP0005377_hearing/vestibular/ear_phenot3.81044390
7MP0000681_abnormal_thyroid_gland3.56199820
8MP0005332_abnormal_amino_acid3.38327374
9MP0001765_abnormal_ion_homeostasis3.21783512
10MP0008875_abnormal_xenobiotic_pharmacok3.17568749
11MP0002139_abnormal_hepatobiliary_system3.14810917
12* MP0009643_abnormal_urine_homeostasis3.08144250
13MP0002138_abnormal_hepatobiliary_system3.07276807
14MP0001501_abnormal_sleep_pattern2.96899499
15MP0002653_abnormal_ependyma_morphology2.86387675
16MP0004264_abnormal_extraembryonic_tissu2.80979109
17MP0003195_calcinosis2.80912928
18MP0005083_abnormal_biliary_tract2.52380951
19MP0002277_abnormal_respiratory_mucosa2.49996740
20MP0005636_abnormal_mineral_homeostasis2.45566511
21MP0005085_abnormal_gallbladder_physiolo2.42961329
22MP0002796_impaired_skin_barrier2.36659923
23MP0002136_abnormal_kidney_physiology2.32958148
24MP0005365_abnormal_bile_salt2.26565459
25MP0001756_abnormal_urination2.23095215
26MP0001984_abnormal_olfaction2.20791361
27MP0003183_abnormal_peptide_metabolism2.18719565
28MP0003252_abnormal_bile_duct2.16131344
29MP0001666_abnormal_nutrient_absorption2.13503419
30MP0003300_gastrointestinal_ulcer2.12961163
31MP0000538_abnormal_urinary_bladder2.04979729
32MP0004782_abnormal_surfactant_physiolog2.02133206
33MP0002160_abnormal_reproductive_system1.98302277
34MP0001958_emphysema1.83081639
35MP0002876_abnormal_thyroid_physiology1.70208556
36MP0005451_abnormal_body_composition1.68237016
37MP0003283_abnormal_digestive_organ1.64484441
38MP0001502_abnormal_circadian_rhythm1.63559088
39MP0000613_abnormal_salivary_gland1.56639692
40MP0002254_reproductive_system_inflammat1.54806880
41MP0010678_abnormal_skin_adnexa1.49995602
42MP0002909_abnormal_adrenal_gland1.49212062
43MP0004885_abnormal_endolymph1.49016536
44MP0005501_abnormal_skin_physiology1.48858351
45MP0002098_abnormal_vibrissa_morphology1.48520714
46MP0002282_abnormal_trachea_morphology1.39177722
47MP0008004_abnormal_stomach_pH1.38284876
48MP0008872_abnormal_physiological_respon1.38211658
49MP0003866_abnormal_defecation1.34314224
50MP0005058_abnormal_lysosome_morphology1.33838081
51MP0000427_abnormal_hair_cycle1.33358051
52MP0003950_abnormal_plasma_membrane1.31426914
53MP0005646_abnormal_pituitary_gland1.30146031
54MP0002638_abnormal_pupillary_reflex1.29749631
55MP0005551_abnormal_eye_electrophysiolog1.26823920
56MP0005503_abnormal_tendon_morphology1.24404589
57MP0004147_increased_porphyrin_level1.23186303
58MP0002896_abnormal_bone_mineralization1.21171701
59MP0005408_hypopigmentation1.21155051
60MP0002132_abnormal_respiratory_system1.18235853
61MP0001873_stomach_inflammation1.18153644
62MP0001764_abnormal_homeostasis1.17467952
63MP0001663_abnormal_digestive_system1.17249467
64MP0005389_reproductive_system_phenotype1.15835381
65MP0001879_abnormal_lymphatic_vessel1.13013070
66* MP0005310_abnormal_salivary_gland1.12787861
67MP0003868_abnormal_feces_composition1.10946134
68MP0000462_abnormal_digestive_system1.10406775
69MP0004742_abnormal_vestibular_system1.10052160
70MP0005381_digestive/alimentary_phenotyp1.08730780
71MP0005395_other_phenotype1.08543730
72MP0005584_abnormal_enzyme/coenzyme_acti1.08078591
73MP0003705_abnormal_hypodermis_morpholog1.04893058
74MP0000579_abnormal_nail_morphology1.03257370
75MP0009384_cardiac_valve_regurgitation1.03025960
76MP0005084_abnormal_gallbladder_morpholo1.01420212
77MP0000377_abnormal_hair_follicle0.99157384
78MP0010155_abnormal_intestine_physiology0.98132421
79MP0005319_abnormal_enzyme/_coenzyme0.98086187
80MP0004215_abnormal_myocardial_fiber0.97095540
81MP0003191_abnormal_cellular_cholesterol0.96361710
82MP0005275_abnormal_skin_tensile0.95859600
83MP0001216_abnormal_epidermal_layer0.93712635
84MP0005248_abnormal_Harderian_gland0.92956176
85MP0003186_abnormal_redox_activity0.91921799
86MP0001849_ear_inflammation0.91734092
87MP0008961_abnormal_basal_metabolism0.91574348
88MP0005167_abnormal_blood-brain_barrier0.91120958
89MP0002168_other_aberrant_phenotype0.90683897
90MP0000762_abnormal_tongue_morphology0.88640899
91MP0000372_irregular_coat_pigmentation0.86279666
92MP0010352_gastrointestinal_tract_polyps0.85206951
93MP0001790_abnormal_immune_system0.84741370
94MP0005387_immune_system_phenotype0.84741370
95MP0003806_abnormal_nucleotide_metabolis0.84075667
96MP0002822_catalepsy0.83735896
97MP0000537_abnormal_urethra_morphology0.82832568
98MP0002135_abnormal_kidney_morphology0.82722276
99MP0001270_distended_abdomen0.82660578
100MP0010329_abnormal_lipoprotein_level0.81194104
101MP0000465_gastrointestinal_hemorrhage0.80205016
102MP0003453_abnormal_keratinocyte_physiol0.78795698
103MP0000477_abnormal_intestine_morphology0.78703008
104MP0003566_abnormal_cell_adhesion0.78654528
105MP0000230_abnormal_systemic_arterial0.78118175
106MP0002166_altered_tumor_susceptibility0.77184662
107MP0005666_abnormal_adipose_tissue0.77026243
108MP0002089_abnormal_postnatal_growth/wei0.76133673
109MP0002734_abnormal_mechanical_nocicepti0.75964038
110MP0003938_abnormal_ear_development0.75357584
111MP0001664_abnormal_digestion0.75077661
112MP0004133_heterotaxia0.74854648
113MP0002118_abnormal_lipid_homeostasis0.73575379
114MP0001919_abnormal_reproductive_system0.72941969
115MP0003329_amyloid_beta_deposits0.72532323
116MP0005499_abnormal_olfactory_system0.71161773
117MP0005394_taste/olfaction_phenotype0.71161773
118MP0003953_abnormal_hormone_level0.71126147
119MP0001346_abnormal_lacrimal_gland0.71043576
120MP0000026_abnormal_inner_ear0.70518611
121MP0002735_abnormal_chemical_nociception0.69665095
122MP0002229_neurodegeneration0.69047047
123MP0003943_abnormal_hepatobiliary_system0.68294147
124MP0002090_abnormal_vision0.65837934
125MP0002108_abnormal_muscle_morphology0.65582305
126MP0005166_decreased_susceptibility_to0.65497567
127MP0002060_abnormal_skin_morphology0.65428880
128MP0000467_abnormal_esophagus_morphology0.64038362
129MP0008775_abnormal_heart_ventricle0.64032720
130MP0010771_integument_phenotype0.63485557
131MP0000383_abnormal_hair_follicle0.63323340
132MP0001485_abnormal_pinna_reflex0.63215470
133MP0001881_abnormal_mammary_gland0.63149829
134MP0003941_abnormal_skin_development0.63034202
135MP0003724_increased_susceptibility_to0.62375884
136MP0010386_abnormal_urinary_bladder0.61955104
137MP0003315_abnormal_perineum_morphology0.61704805
138MP0005645_abnormal_hypothalamus_physiol0.61490615
139MP0003045_fibrosis0.61339459
140MP0004272_abnormal_basement_membrane0.61335486
141MP0002133_abnormal_respiratory_system0.61302027
142MP0005388_respiratory_system_phenotype0.61302027
143MP0008789_abnormal_olfactory_epithelium0.60858191
144MP0003698_abnormal_male_reproductive0.60490413
145MP0003890_abnormal_embryonic-extraembry0.59727753
146MP0005220_abnormal_exocrine_pancreas0.59665945
147MP0002736_abnormal_nociception_after0.59436033
148MP0002928_abnormal_bile_duct0.59042831
149MP0009780_abnormal_chondrocyte_physiolo0.58634936
150MP0006054_spinal_hemorrhage0.58127406
151MP0000609_abnormal_liver_physiology0.57538702
152MP0003638_abnormal_response/metabolism_0.57144969
153MP0000678_abnormal_parathyroid_gland0.55956055
154MP0000163_abnormal_cartilage_morphology0.52317822
155MP0004484_altered_response_of0.51969213
156MP0004947_skin_inflammation0.51440819
157MP0009642_abnormal_blood_homeostasis0.51152814
158MP0003795_abnormal_bone_structure0.51024833
159MP0002009_preneoplasia0.51022981
160MP0009764_decreased_sensitivity_to0.50883282

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.08584454
2Abnormal ciliary motility (HP:0012262)8.90269956
3Abnormal respiratory motile cilium morphology (HP:0005938)8.79747708
4Abnormal respiratory epithelium morphology (HP:0012253)8.79747708
5Absent/shortened dynein arms (HP:0200106)8.72095723
6Dynein arm defect of respiratory motile cilia (HP:0012255)8.72095723
7Rhinitis (HP:0012384)8.71776126
8Metabolic alkalosis (HP:0200114)7.19584915
9Hyperactive renin-angiotensin system (HP:0000841)7.14596066
10Chronic bronchitis (HP:0004469)7.02475221
11Increased circulating renin level (HP:0000848)6.73420963
12Bronchiectasis (HP:0002110)6.48312790
13Abnormality of chloride homeostasis (HP:0011422)6.21013087
14Hypokalemic alkalosis (HP:0001949)6.18704542
15Hypomagnesemia (HP:0002917)6.06756003
16Gout (HP:0001997)5.87527040
17Polyuria (HP:0000103)5.25648769
18Abnormality of magnesium homeostasis (HP:0004921)5.25293804
19Nasal polyposis (HP:0100582)5.21152732
20Abnormality of glutamine family amino acid metabolism (HP:0010902)5.07176421
21Abnormality of renal excretion (HP:0011036)5.03169553
22Abnormal urine output (HP:0012590)5.02342191
23Abnormality of renin-angiotensin system (HP:0000847)4.80954301
24Proximal tubulopathy (HP:0000114)4.66290195
25Tetany (HP:0001281)4.61226821
26Hyperaldosteronism (HP:0000859)4.51017628
27Bronchitis (HP:0012387)4.47302976
28Abnormality of the nasal mucosa (HP:0000433)4.35366867
29Hyperglycinuria (HP:0003108)4.30457357
30Increased purine levels (HP:0004368)4.29235262
31Hyperuricemia (HP:0002149)4.29235262
32Alkalosis (HP:0001948)4.28136601
33Polydipsia (HP:0001959)4.14684187
34Abnormal drinking behavior (HP:0030082)4.14684187
35Renal salt wasting (HP:0000127)4.10407854
36Abnormality of purine metabolism (HP:0004352)4.02955600
37Chronic sinusitis (HP:0011109)3.95897510
38Goiter (HP:0000853)3.79402440
39Abnormality of proline metabolism (HP:0010907)3.61436175
40Hydroxyprolinuria (HP:0003080)3.61436175
41Renal tubular acidosis (HP:0001947)3.61385121
42Recurrent sinusitis (HP:0011108)3.60358193
43Hypokalemia (HP:0002900)3.51296393
44Hypercalciuria (HP:0002150)3.49808730
45Abnormality of serine family amino acid metabolism (HP:0010894)3.31193361
46Abnormality of glycine metabolism (HP:0010895)3.31193361
47Pancreatic cysts (HP:0001737)3.30442439
48Pancreatic fibrosis (HP:0100732)3.28999294
49True hermaphroditism (HP:0010459)3.22076789
50Infertility (HP:0000789)3.14143365
51Generalized aminoaciduria (HP:0002909)3.13151846
52Glycosuria (HP:0003076)3.12998662
53Abnormality of urine glucose concentration (HP:0011016)3.12998662
54Chronic hepatic failure (HP:0100626)3.11008367
55Delayed epiphyseal ossification (HP:0002663)3.10684090
56Dehydration (HP:0001944)3.08827960
57Ketoacidosis (HP:0001993)3.06129227
58Congenital sensorineural hearing impairment (HP:0008527)3.04614424
59Abnormal tarsal ossification (HP:0008369)3.02673435
60Recurrent otitis media (HP:0000403)3.02062615
61Right ventricular cardiomyopathy (HP:0011663)2.97133722
62Abnormality of potassium homeostasis (HP:0011042)2.94010135
63Thyroid-stimulating hormone excess (HP:0002925)2.92220781
64Widely patent fontanelles and sutures (HP:0004492)2.88580392
65Abnormality of midbrain morphology (HP:0002418)2.85088271
66Molar tooth sign on MRI (HP:0002419)2.85088271
67Nephrolithiasis (HP:0000787)2.85031843
68Malnutrition (HP:0004395)2.84385557
69Abnormality of nucleobase metabolism (HP:0010932)2.81717096
70Vascular calcification (HP:0004934)2.81446345
71Nephronophthisis (HP:0000090)2.73237128
72Chronic otitis media (HP:0000389)2.72626632
73Recurrent bronchitis (HP:0002837)2.71872058
74Hyperphosphaturia (HP:0003109)2.70148716
75Cystic liver disease (HP:0006706)2.66713670
76Thin bony cortex (HP:0002753)2.64555059
77Abnormality of the renal medulla (HP:0100957)2.64261995
78Occipital encephalocele (HP:0002085)2.63227767
79Abnormal urine phosphate concentration (HP:0012599)2.61162650
80Flat acetabular roof (HP:0003180)2.60021696
81Vacuolated lymphocytes (HP:0001922)2.56289984
82Rickets (HP:0002748)2.54738293
83Cardiovascular calcification (HP:0011915)2.52490095
84Abnormality of aspartate family amino acid metabolism (HP:0010899)2.50029719
85Nephrocalcinosis (HP:0000121)2.48923882
86Abnormality of carpal bone ossification (HP:0006257)2.48338682
87Onycholysis (HP:0001806)2.45995387
88Hypophosphatemia (HP:0002148)2.44999211
89Male infertility (HP:0003251)2.43647456
90Ketosis (HP:0001946)2.39591687
91Ileus (HP:0002595)2.35064600
92Tubular atrophy (HP:0000092)2.34718861
93Abnormality of the renal cortex (HP:0011035)2.29089884
94Abnormality of fatty-acid metabolism (HP:0004359)2.28942536
95Adrenal overactivity (HP:0002717)2.28130530
96Facial shape deformation (HP:0011334)2.26847227
97Potter facies (HP:0002009)2.26847227
98Medial flaring of the eyebrow (HP:0010747)2.25296809
99Abnormality of sodium homeostasis (HP:0010931)2.23631511
100Metaphyseal irregularity (HP:0003025)2.21265155
101Bilateral sensorineural hearing impairment (HP:0008619)2.20370704
102Pili torti (HP:0003777)2.18794595
103Confusion (HP:0001289)2.17925701
104Hyponatremia (HP:0002902)2.17267448
105Congenital hepatic fibrosis (HP:0002612)2.14131810
106Tubulointerstitial nephritis (HP:0001970)2.13552989
107Hyperkalemia (HP:0002153)2.12935037
108Enlarged epiphyses (HP:0010580)2.09531922
109Metaphyseal cupping (HP:0003021)2.08667741
110Abnormal foot bone ossification (HP:0010675)2.07969664
111Abnormal enzyme/coenzyme activity (HP:0012379)2.06704976
112Abnormality of the costochondral junction (HP:0000919)2.05900181
113Decreased circulating renin level (HP:0003351)2.05077992
114Thyroid carcinoma (HP:0002890)2.04977198
115Hyperammonemia (HP:0001987)2.04419289
116Abnormality of alkaline phosphatase activity (HP:0004379)2.04251150
117Renal tubular dysfunction (HP:0000124)2.03370284
118Glomerulosclerosis (HP:0000096)2.01852030
119Hypothermia (HP:0002045)2.01794114
120Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4138617
121Male pseudohermaphroditism (HP:0000037)1.99929114
122Furrowed tongue (HP:0000221)1.99660155
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98619318
124Dicarboxylic aciduria (HP:0003215)1.98619318
125Neonatal short-limb short stature (HP:0008921)1.97768940
126Delayed CNS myelination (HP:0002188)1.97434415
127Postaxial foot polydactyly (HP:0001830)1.95438135
128Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.94903818
129Lip pit (HP:0100267)1.94416967
130Abnormal ossification of hand bones (HP:0005921)1.94165840
131Gait imbalance (HP:0002141)1.93530132
132Hyperglycinemia (HP:0002154)1.92574030
133Abnormal hand bone ossification (HP:0010660)1.92409474
134Abnormality of renal resorption (HP:0011038)1.92284771
135Abnormality of sulfur amino acid metabolism (HP:0004339)1.89596289
136Metabolic acidosis (HP:0001942)1.88730513
137Congenital primary aphakia (HP:0007707)1.88613596
138Tubulointerstitial fibrosis (HP:0005576)1.84950948
139Abnormality of macular pigmentation (HP:0008002)1.84351686
140Abdominal distention (HP:0003270)1.83301343
141Abnormality of the middle phalanges of the toes (HP:0010183)1.81706786
142Atelectasis (HP:0100750)1.78448267
143Advanced eruption of teeth (HP:0006288)1.77546799
144Milia (HP:0001056)1.77268844
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.76318064
146Vomiting (HP:0002013)1.75830374
147Focal segmental glomerulosclerosis (HP:0000097)1.74684923
148Protuberant abdomen (HP:0001538)1.74523031
149Hyperphosphatemia (HP:0002905)1.74266701
150Nephropathy (HP:0000112)1.73113194
151Anencephaly (HP:0002323)1.72442504
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.72080261
153Nephrogenic diabetes insipidus (HP:0009806)1.69599581
154Enlarged kidneys (HP:0000105)1.68995340
155Bicornuate uterus (HP:0000813)1.68927974
156Bell-shaped thorax (HP:0001591)1.67657470
157Ventricular fibrillation (HP:0001663)1.57362547
158Decreased central vision (HP:0007663)1.55049922
159Vaginal atresia (HP:0000148)1.53142060
160Absent rod-and cone-mediated responses on ERG (HP:0007688)1.52569473
161Genital tract atresia (HP:0001827)1.51698529
162Hypoplastic labia majora (HP:0000059)1.47760139
163Cone-rod dystrophy (HP:0000548)1.46966703
164Tubulointerstitial abnormality (HP:0001969)1.42109210
165Oculomotor apraxia (HP:0000657)1.40343368
166Postaxial hand polydactyly (HP:0001162)1.39492165
167Abnormality of the dental root (HP:0006486)1.39336185
168Taurodontia (HP:0000679)1.39336185
169Abnormality of permanent molar morphology (HP:0011071)1.39336185
170Aplasia of the musculature (HP:0100854)1.38341342
171Sclerocornea (HP:0000647)1.38101251
172Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.38091528
173Poor coordination (HP:0002370)1.37776046
174Hand muscle atrophy (HP:0009130)1.36705150
175Abnormal rod and cone electroretinograms (HP:0008323)1.33863883
176Abnormal hair laboratory examination (HP:0003328)1.33366910
177Stage 5 chronic kidney disease (HP:0003774)1.33127462
178Amelogenesis imperfecta (HP:0000705)1.31017197
179Abnormality of the dental pulp (HP:0006479)1.30485273
180Hyperventilation (HP:0002883)1.28842914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.94651181
2OXSR16.10717422
3WNK35.88716259
4MAPK155.34667043
5STK394.13656316
6MST1R3.86078450
7MST43.73601357
8BRSK23.09255093
9FRK2.69837566
10CAMKK22.51542811
11STK38L2.07358464
12FER2.00427971
13EPHA21.86007983
14ACVR1B1.84846261
15EPHB11.83752628
16STK241.80676850
17MAPK131.64054336
18BCKDK1.64051489
19EIF2AK31.59311501
20PDK41.55957495
21PDK31.55957495
22LATS11.47969114
23MAP3K121.47092445
24WNK11.43809585
25PIK3CA1.43339031
26MET1.43199843
27ERBB31.42939346
28PTK61.37878152
29BMPR1B1.35359654
30NEK11.35230872
31LMTK21.33694648
32PDK21.25687377
33NEK61.24686426
34RIPK11.15583493
35SGK2231.15094054
36SGK4941.15094054
37FGFR41.14495018
38PTK21.13162583
39LRRK21.10254914
40EPHB21.09507022
41MAP2K21.08755905
42MAP3K21.08178475
43MAP4K21.06379025
44MAP3K71.05733593
45NME11.02358738
46ERN11.01628784
47PTK2B0.99177527
48CAMKK10.97118214
49ADRBK20.94588191
50GRK60.94500811
51STK380.94324913
52EEF2K0.92361013
53PNCK0.91621942
54EPHA30.84600624
55RPS6KB20.81869820
56PAK30.80663163
57IRAK10.80528980
58PAK40.79553725
59MAP3K30.79180033
60TESK10.78860656
61PRKD30.78472133
62STK100.77301221
63SGK30.76935811
64MYLK0.76629576
65PRKCI0.74776141
66DMPK0.73838735
67PINK10.68854555
68PRKCQ0.68642699
69DYRK1B0.67610538
70RPS6KB10.65928403
71PRKG20.65920576
72TEC0.65084762
73MATK0.64657297
74SIK10.64021428
75GSK3A0.63343771
76ERBB20.60833199
77ADRBK10.60640225
78BMX0.59848786
79SGK20.59605836
80PRKAA20.57311517
81CHUK0.56460405
82MAP2K10.55230801
83CASK0.54870633
84TLK10.54549081
85FGFR20.53357003
86NLK0.53241011
87TRIM280.52794579
88MAP3K140.51801755
89TIE10.50644918
90MUSK0.49043711
91PRKAA10.48948112
92TTK0.48730008
93JAK10.48429128
94IKBKE0.47031426
95PDPK10.46480106
96MAPK110.44843730
97GRK10.43427070
98BRSK10.41321485
99RET0.40713158
100SGK10.40329112
101STK30.40176001
102IKBKB0.38809464
103ABL10.38563512
104INSRR0.38227732
105DDR20.36809037
106TGFBR20.34980640
107CAMK2A0.34748088
108HIPK20.34193383
109TNK20.33160767
110PRKACA0.32212824
111MKNK20.32021763
112TAOK10.31687579
113MAPKAPK30.30481980
114MAPKAPK50.29794096
115YES10.29318201
116MELK0.28756874
117MAP3K100.27703778
118PHKG20.27640787
119PHKG10.27640787
120EGFR0.27152800
121ROCK10.26517593
122IGF1R0.26050022
123TYK20.25443058
124PDK10.24466419
125SRC0.22320530
126NUAK10.21511445
127MAP3K10.21491139
128TRPM70.20549606
129IRAK30.20409455
130BCR0.19872007
131FGFR30.19819329
132RIPK40.19639085
133PRKCA0.19143902
134ERBB40.17966392
135JAK20.17606400
136PRKCD0.17567538
137ITK0.17459798
138TRIB30.17438646
139CDK60.16952518
140CAMK2D0.16676479
141PRKCZ0.16586182
142ABL20.16303537
143KSR20.15829593
144NME20.14370437
145CSNK1A10.13469884
146MAP3K80.12853567
147CSK0.12039212
148PRKACG0.11973923
149INSR0.11814331
150PRKCE0.10887432
151CAMK2G0.10492450
152PIK3CG0.10378607
153MAP3K90.09873522
154AKT30.09140543

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.60898208
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.37054246
3Butanoate metabolism_Homo sapiens_hsa006503.34356662
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29387673
5Pentose and glucuronate interconversions_Homo sapiens_hsa000403.13034291
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.10007051
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76219571
8Linoleic acid metabolism_Homo sapiens_hsa005912.64855646
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56590287
10Mineral absorption_Homo sapiens_hsa049782.51241500
11Propanoate metabolism_Homo sapiens_hsa006402.39563907
12Vitamin digestion and absorption_Homo sapiens_hsa049772.39287338
13Autoimmune thyroid disease_Homo sapiens_hsa053202.37695369
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18293096
15Fatty acid degradation_Homo sapiens_hsa000712.00537213
16Bile secretion_Homo sapiens_hsa049761.98797223
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.95511748
18Tryptophan metabolism_Homo sapiens_hsa003801.94581650
19Collecting duct acid secretion_Homo sapiens_hsa049661.94508402
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88499297
21Pyruvate metabolism_Homo sapiens_hsa006201.84985575
22Peroxisome_Homo sapiens_hsa041461.84619916
23beta-Alanine metabolism_Homo sapiens_hsa004101.81786398
24Histidine metabolism_Homo sapiens_hsa003401.80693779
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80227925
26Circadian rhythm_Homo sapiens_hsa047101.76749897
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72825728
28Protein digestion and absorption_Homo sapiens_hsa049741.70177499
29Glutathione metabolism_Homo sapiens_hsa004801.65676572
30Renin-angiotensin system_Homo sapiens_hsa046141.47531940
31Fatty acid metabolism_Homo sapiens_hsa012121.38411302
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34436612
33Starch and sucrose metabolism_Homo sapiens_hsa005001.33629206
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30853196
35PPAR signaling pathway_Homo sapiens_hsa033201.28113858
36Arginine and proline metabolism_Homo sapiens_hsa003301.27705531
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27326163
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20653172
39Carbon metabolism_Homo sapiens_hsa012001.16410613
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15827726
41Glycerolipid metabolism_Homo sapiens_hsa005611.08164824
42Fructose and mannose metabolism_Homo sapiens_hsa000511.07304808
43Asthma_Homo sapiens_hsa053101.05077400
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04865877
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04032944
46Other glycan degradation_Homo sapiens_hsa005111.01608529
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.97943560
48Phenylalanine metabolism_Homo sapiens_hsa003600.95058472
49Thyroid hormone synthesis_Homo sapiens_hsa049180.94767738
50Regulation of autophagy_Homo sapiens_hsa041400.94021660
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93488367
52Lysine degradation_Homo sapiens_hsa003100.92470599
53Phototransduction_Homo sapiens_hsa047440.92197103
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90883147
55Huntingtons disease_Homo sapiens_hsa050160.90496569
56Caffeine metabolism_Homo sapiens_hsa002320.84386296
57Selenocompound metabolism_Homo sapiens_hsa004500.84099836
58Fat digestion and absorption_Homo sapiens_hsa049750.84095816
59Ether lipid metabolism_Homo sapiens_hsa005650.83289249
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83008449
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82374192
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79780607
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.77459186
64Arginine biosynthesis_Homo sapiens_hsa002200.76683808
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76012291
66Chemical carcinogenesis_Homo sapiens_hsa052040.75908919
67Folate biosynthesis_Homo sapiens_hsa007900.74874868
68Allograft rejection_Homo sapiens_hsa053300.73144779
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.72997719
70Graft-versus-host disease_Homo sapiens_hsa053320.72808340
71Sulfur relay system_Homo sapiens_hsa041220.72554111
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70997676
73Vibrio cholerae infection_Homo sapiens_hsa051100.67976933
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67726394
75Type I diabetes mellitus_Homo sapiens_hsa049400.66805887
76Gastric acid secretion_Homo sapiens_hsa049710.65341329
77Olfactory transduction_Homo sapiens_hsa047400.63330781
78Taste transduction_Homo sapiens_hsa047420.63179059
79ABC transporters_Homo sapiens_hsa020100.60569051
80Galactose metabolism_Homo sapiens_hsa000520.59344749
81Arachidonic acid metabolism_Homo sapiens_hsa005900.56970529
82Tight junction_Homo sapiens_hsa045300.56665471
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.55863638
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55702100
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54412303
86Fatty acid biosynthesis_Homo sapiens_hsa000610.53401539
87Sphingolipid metabolism_Homo sapiens_hsa006000.53131150
88Serotonergic synapse_Homo sapiens_hsa047260.52488333
89Calcium signaling pathway_Homo sapiens_hsa040200.52152840
90Retinol metabolism_Homo sapiens_hsa008300.52088670
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51183917
92Lysosome_Homo sapiens_hsa041420.47992136
93Staphylococcus aureus infection_Homo sapiens_hsa051500.44971399
94Metabolic pathways_Homo sapiens_hsa011000.44452112
95Dorso-ventral axis formation_Homo sapiens_hsa043200.42649979
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41682040
97Renin secretion_Homo sapiens_hsa049240.41477414
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.41270660
99Complement and coagulation cascades_Homo sapiens_hsa046100.40693487
100Ovarian steroidogenesis_Homo sapiens_hsa049130.39942251
101Pentose phosphate pathway_Homo sapiens_hsa000300.39542691
102Biosynthesis of amino acids_Homo sapiens_hsa012300.38884276
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37588107
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.36019274
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35272416
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.35134491
107Antigen processing and presentation_Homo sapiens_hsa046120.34623620
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.34078995
109Adherens junction_Homo sapiens_hsa045200.33811194
110Fatty acid elongation_Homo sapiens_hsa000620.33766036
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33332842
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33086905
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.32740739
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32410347
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.31649401
116Bladder cancer_Homo sapiens_hsa052190.31008663
117Pancreatic secretion_Homo sapiens_hsa049720.30929483
118ECM-receptor interaction_Homo sapiens_hsa045120.30740913
119Protein export_Homo sapiens_hsa030600.24673129
120Choline metabolism in cancer_Homo sapiens_hsa052310.23659818
121cAMP signaling pathway_Homo sapiens_hsa040240.23076088
122Steroid biosynthesis_Homo sapiens_hsa001000.22858111
123Hepatitis C_Homo sapiens_hsa051600.22166579
124Oxidative phosphorylation_Homo sapiens_hsa001900.20842195
125Insulin resistance_Homo sapiens_hsa049310.20529934
126Tyrosine metabolism_Homo sapiens_hsa003500.20312395
127Salivary secretion_Homo sapiens_hsa049700.19467367
128Glutamatergic synapse_Homo sapiens_hsa047240.19019796
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.17965240
130Cocaine addiction_Homo sapiens_hsa050300.17236968
131Inositol phosphate metabolism_Homo sapiens_hsa005620.16998603
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15868572
133Nitrogen metabolism_Homo sapiens_hsa009100.15490529
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13698531
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12880672
136Amoebiasis_Homo sapiens_hsa051460.12632073
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10134336

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