ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome condensation (GO:0030261)	9.69697187
2	DNA packaging (GO:0006323)	9.37705896
3	sperm capacitation (GO:0048240)	8.85984722
4	response to pheromone (GO:0019236)	8.64765369
5	plasma membrane fusion (GO:0045026)	7.87213808
6	spermatid development (GO:0007286)	7.86654908
7	single strand break repair (GO:0000012)	7.77245465
8	microtubule depolymerization (GO:0007019)	7.61502383
9	spermatid nucleus differentiation (GO:0007289)	7.56432130
10	sperm-egg recognition (GO:0035036)	7.18506587
11	binding of sperm to zona pellucida (GO:0007339)	7.00653706
12	negative regulation of inclusion body assembly (GO:0090084)	6.99882194
13	sexual reproduction (GO:0019953)	6.96661024
14	microtubule polymerization or depolymerization (GO:0031109)	6.15301568
15	rRNA methylation (GO:0031167)	6.14528040
16	calcium ion-dependent exocytosis (GO:0017156)	5.98672158
17	reproduction (GO:0000003)	5.97165393
18	multicellular organism reproduction (GO:0032504)	5.90364552
19	spermatogenesis (GO:0007283)	5.85378953
20	male gamete generation (GO:0048232)	5.83578224
21	cell-cell recognition (GO:0009988)	5.83328077
22	protein polyglutamylation (GO:0018095)	5.77242499
23	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.72898989
24	protein targeting to Golgi (GO:0000042)	5.41205988
25	gamete generation (GO:0007276)	5.36423387
26	microtubule severing (GO:0051013)	5.34497148
27	histone H3-K9 demethylation (GO:0033169)	5.23590986
28	phosphatidylethanolamine metabolic process (GO:0046337)	5.22291685
29	establishment of protein localization to Golgi (GO:0072600)	5.16427212
30	axonemal dynein complex assembly (GO:0070286)	5.15525972
31	rRNA modification (GO:0000154)	5.06350408
32	male meiosis I (GO:0007141)	5.03595942
33	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.03217120
34	positive regulation of Rab GTPase activity (GO:0032851)	4.92605420
35	regulation of Rab GTPase activity (GO:0032313)	4.92605420
36	centriole replication (GO:0007099)	4.88345956
37	regulation of inclusion body assembly (GO:0090083)	4.87546914
38	piRNA metabolic process (GO:0034587)	4.76986640
39	cellular ketone body metabolic process (GO:0046950)	4.74098749
40	germ cell development (GO:0007281)	4.73344092
41	chromatin silencing (GO:0006342)	4.71941359
42	DNA methylation involved in gamete generation (GO:0043046)	4.68000986
43	regulation of cilium movement (GO:0003352)	4.60040366
44	motile cilium assembly (GO:0044458)	4.51836667
45	centriole assembly (GO:0098534)	4.49313297
46	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.46193619
47	nucleus organization (GO:0006997)	4.36144045
48	regulation of transcription involved in cell fate commitment (GO:0060850)	4.34740092
49	multicellular organismal reproductive process (GO:0048609)	4.31893350
50	male meiosis (GO:0007140)	4.31573024
51	single fertilization (GO:0007338)	4.29516602
52	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.26969222
53	ketone body metabolic process (GO:1902224)	4.16798056
54	fertilization (GO:0009566)	4.11822526
55	regulation of centriole replication (GO:0046599)	3.98603930
56	protein localization to Golgi apparatus (GO:0034067)	3.94761151
57	negative regulation of Rho protein signal transduction (GO:0035024)	3.89691703
58	meiosis I (GO:0007127)	3.88037763
59	cilium or flagellum-dependent cell motility (GO:0001539)	3.81220508
60	cell wall macromolecule catabolic process (GO:0016998)	3.75685711
61	chromosome organization involved in meiosis (GO:0070192)	3.73634621
62	coenzyme catabolic process (GO:0009109)	3.73131529
63	synaptonemal complex assembly (GO:0007130)	3.72554844
64	synapsis (GO:0007129)	3.71839669
65	regulation of microtubule-based movement (GO:0060632)	3.71647782
66	RNA destabilization (GO:0050779)	3.66623537
67	cell wall macromolecule metabolic process (GO:0044036)	3.64141118
68	nucleosome disassembly (GO:0006337)	3.56660353
69	protein-DNA complex disassembly (GO:0032986)	3.56660353
70	meiotic nuclear division (GO:0007126)	3.54551551
71	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.52139339
72	cranial nerve morphogenesis (GO:0021602)	3.49974702
73	peptidyl-threonine dephosphorylation (GO:0035970)	3.41419226
74	DNA conformation change (GO:0071103)	3.37752883
75	organic cation transport (GO:0015695)	3.33791901
76	regulation of somitogenesis (GO:0014807)	3.32504754
77	glycerol ether metabolic process (GO:0006662)	3.32098302
78	cerebral cortex neuron differentiation (GO:0021895)	3.28110994
79	response to acidic pH (GO:0010447)	3.28034053
80	synaptonemal complex organization (GO:0070193)	3.26876255
81	negative regulation of gene expression, epigenetic (GO:0045814)	3.25987006
82	negative regulation of histone methylation (GO:0031061)	3.19449661
83	seminiferous tubule development (GO:0072520)	3.14754577
84	protein depolymerization (GO:0051261)	3.09309876
85	metanephric mesenchyme development (GO:0072075)	3.07344146
86	homeostasis of number of cells within a tissue (GO:0048873)	3.07146050
87	cellular response to pH (GO:0071467)	3.05389378
88	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.04638922
89	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.04638922
90	musculoskeletal movement (GO:0050881)	3.03875947
91	multicellular organismal movement (GO:0050879)	3.03875947
92	polyamine biosynthetic process (GO:0006596)	3.03503585
93	ether metabolic process (GO:0018904)	3.03099582
94	coronary vasculature morphogenesis (GO:0060977)	3.01739579
95	multicellular organismal development (GO:0007275)	2.98442037
96	epithelial cilium movement (GO:0003351)	2.97794242
97	regulation of interleukin-13 production (GO:0032656)	2.89579443
98	acrosome reaction (GO:0007340)	11.5851037
99	sperm motility (GO:0030317)	10.4999760
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.4594577

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.85607328
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.83844264
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.10688065
4	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.61802465
5	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.26092472
6	ERA_21632823_ChIP-Seq_H3396_Human	2.24831397
7	SMC4_20622854_ChIP-Seq_HELA_Human	2.22291727
8	P68_20966046_ChIP-Seq_HELA_Human	2.17669538
9	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.14705397
10	CTCF_27219007_Chip-Seq_Bcells_Human	2.14518094
11	YY1_22570637_ChIP-Seq_MALME-3M_Human	2.13812850
12	E2F1_20622854_ChIP-Seq_HELA_Human	2.05264492
13	LXR_22292898_ChIP-Seq_THP-1_Human	2.03966984
14	BCL6_27268052_Chip-Seq_Bcells_Human	2.03344374
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.02529539
16	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.02529539
17	RAC3_21632823_ChIP-Seq_H3396_Human	2.00380337
18	PHF8_20622854_ChIP-Seq_HELA_Human	1.99020679
19	BCOR_27268052_Chip-Seq_Bcells_Human	1.97645998
20	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.97435660
21	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.97065637
22	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.90873242
23	TP63_22573176_ChIP-Seq_HFKS_Human	1.79288702
24	NANOG_20526341_ChIP-Seq_ESCs_Human	1.77011926
25	CTCF_20526341_ChIP-Seq_ESCs_Human	1.74061588
26	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.73347234
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.68235369
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68235369
29	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.65496876
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64900361
31	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.63458256
32	MYC_19829295_ChIP-Seq_ESCs_Human	1.56800940
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.56774797
34	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.55791145
35	P300_27268052_Chip-Seq_Bcells_Human	1.55351236
36	OCT4_20526341_ChIP-Seq_ESCs_Human	1.55331871
37	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.53955530
38	* WDR5_24793694_ChIP-Seq_LNCAP_Human	1.53457259
39	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.50625397
40	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.50166812
41	SA1_27219007_Chip-Seq_Bcells_Human	1.47696690
42	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.46334208
43	DROSHA_22980978_ChIP-Seq_HELA_Human	1.45200412
44	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42612739
45	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.41840744
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40643260
47	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.40018672
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.37339032
49	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.32530823
50	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.31552955
51	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.30221626
52	RBPJ_21746931_ChIP-Seq_IB4_Human	1.30092061
53	FUS_26573619_Chip-Seq_HEK293_Human	1.28531226
54	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27907954
55	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.26307255
56	ETV1_20927104_ChIP-Seq_GIST48_Human	1.25036008
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.22552213
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21992670
59	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.21878038
60	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21817103
61	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.21284176
62	P53_21459846_ChIP-Seq_SAOS-2_Human	1.21014853
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19619635
64	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.17974558
65	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.17528113
66	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.16650097
67	CTCF_21964334_Chip-Seq_Bcells_Human	1.15440164
68	OCT4_19829295_ChIP-Seq_ESCs_Human	1.13581123
69	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13512107
70	SOX11_22085726_ChIP-Seq_ESNs_Mouse	1.13436794
71	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13375198
72	NFYB_21822215_ChIP-Seq_K562_Human	1.13184032
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12911774
74	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.12671965
75	CEBPB_22108803_ChIP-Seq_LS180_Human	1.12329908
76	PHF8_20622853_ChIP-Seq_HELA_Human	1.11767940
77	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.10655333
78	ERG_20517297_ChIP-Seq_VCAP_Human	1.10080581
79	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.10035457
80	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.09053248
81	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.08041866
82	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.06670259
83	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.05119159
84	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.04828835
85	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04593307
86	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02847049
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02641182
88	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02124732
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01932311
90	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01578073
91	TBL1_22424771_ChIP-Seq_293T_Human	1.01492532
92	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	1.00369505
93	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.00081512
94	* KLF5_25053715_ChIP-Seq_YYC3_Human	0.99876140
95	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.99837724
96	AR_25329375_ChIP-Seq_VCAP_Human	0.99703892
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99555601
98	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.98215216
99	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.98093626
100	KLF4_19829295_ChIP-Seq_ESCs_Human	0.98030611

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	4.81834908
2	MP0003878_abnormal_ear_physiology	4.63007413
3	MP0005377_hearing/vestibular/ear_phenot	4.63007413
4	MP0001929_abnormal_gametogenesis	4.32046328
5	MP0005670_abnormal_white_adipose	4.15928191
6	MP0000678_abnormal_parathyroid_gland	3.95455225
7	MP0001348_abnormal_lacrimal_gland	3.23097182
8	MP0002161_abnormal_fertility/fecundity	2.75444461
9	MP0002210_abnormal_sex_determination	2.60550864
10	MP0008877_abnormal_DNA_methylation	2.49508546
11	MP0003646_muscle_fatigue	2.33454105
12	MP0003718_maternal_effect	2.29880061
13	MP0002249_abnormal_larynx_morphology	2.26344651
14	MP0001145_abnormal_male_reproductive	2.03685127
15	MP0005451_abnormal_body_composition	2.02071701
16	MP0005410_abnormal_fertilization	11.6565752
17	MP0002132_abnormal_respiratory_system	1.90195890
18	MP0000653_abnormal_sex_gland	1.88650272
19	MP0002234_abnormal_pharynx_morphology	1.63247968
20	MP0009053_abnormal_anal_canal	1.50592180
21	MP0002282_abnormal_trachea_morphology	1.49323800
22	MP0003011_delayed_dark_adaptation	1.37728868
23	MP0004233_abnormal_muscle_weight	1.36239671
24	MP0000534_abnormal_ureter_morphology	1.33873435
25	MP0002822_catalepsy	1.33792654
26	MP0005423_abnormal_somatic_nervous	1.23785835
27	MP0002127_abnormal_cardiovascular_syste	1.18137821
28	MP0005666_abnormal_adipose_tissue	1.11005627
29	MP0001485_abnormal_pinna_reflex	1.09586463
30	MP0005379_endocrine/exocrine_gland_phen	1.04618395
31	MP0005310_abnormal_salivary_gland	1.00817808
32	MP0005248_abnormal_Harderian_gland	0.99449470
33	MP0000003_abnormal_adipose_tissue	0.99378745
34	MP0003077_abnormal_cell_cycle	0.97810371
35	MP0005375_adipose_tissue_phenotype	0.97144719
36	MP0003119_abnormal_digestive_system	0.96940834
37	MP0001765_abnormal_ion_homeostasis	0.96280548
38	MP0000681_abnormal_thyroid_gland	0.91620590
39	MP0000049_abnormal_middle_ear	0.91306005
40	MP0003879_abnormal_hair_cell	0.91002292
41	MP0005395_other_phenotype	0.90465469
42	MP0004510_myositis	0.89757491
43	MP0000026_abnormal_inner_ear	0.86047486
44	MP0001486_abnormal_startle_reflex	0.84873751
45	MP0008995_early_reproductive_senescence	0.84560912
46	MP0003693_abnormal_embryo_hatching	0.82204238
47	MP0000955_abnormal_spinal_cord	0.81802586
48	MP0003699_abnormal_female_reproductive	0.80232672
49	MP0004742_abnormal_vestibular_system	0.79643723
50	MP0001963_abnormal_hearing_physiology	0.79364741
51	MP0000566_synostosis	0.78136187
52	MP0004036_abnormal_muscle_relaxation	0.74435659
53	MP0002735_abnormal_chemical_nociception	0.74227733
54	MP0000733_abnormal_muscle_development	0.72237919
55	MP0009115_abnormal_fat_cell	0.71269464
56	MP0004957_abnormal_blastocyst_morpholog	0.69719744
57	MP0000467_abnormal_esophagus_morphology	0.68550500
58	MP0001299_abnormal_eye_distance/	0.66283018
59	MP0008789_abnormal_olfactory_epithelium	0.65257846
60	MP0002229_neurodegeneration	0.64927414
61	MP0003115_abnormal_respiratory_system	0.61561739
62	MP0004085_abnormal_heartbeat	0.61432900
63	MP0001879_abnormal_lymphatic_vessel	0.61312148
64	MP0005409_darkened_coat_color	0.59713922
65	MP0005636_abnormal_mineral_homeostasis	0.59153659
66	MP0001666_abnormal_nutrient_absorption	0.58361656
67	MP0008569_lethality_at_weaning	0.56671361
68	MP0004859_abnormal_synaptic_plasticity	0.56583728
69	MP0002269_muscular_atrophy	0.55305368
70	MP0003936_abnormal_reproductive_system	0.54490763
71	MP0001968_abnormal_touch/_nociception	0.54118919
72	MP0001119_abnormal_female_reproductive	0.52227953
73	MP0003942_abnormal_urinary_system	0.52203466
74	MP0005083_abnormal_biliary_tract	0.51321894
75	MP0010307_abnormal_tumor_latency	0.51243754
76	MP0002138_abnormal_hepatobiliary_system	0.48571951
77	MP0002160_abnormal_reproductive_system	0.48001916
78	MP0002085_abnormal_embryonic_tissue	0.47778426
79	MP0002067_abnormal_sensory_capabilities	0.44543611
80	MP0003861_abnormal_nervous_system	0.43851418
81	MP0000613_abnormal_salivary_gland	0.43615009
82	MP0005367_renal/urinary_system_phenotyp	0.41974339
83	MP0000516_abnormal_urinary_system	0.41974339
84	MP0008770_decreased_survivor_rate	0.41183244
85	MP0002932_abnormal_joint_morphology	0.40986842
86	MP0000470_abnormal_stomach_morphology	0.40401448
87	MP0003385_abnormal_body_wall	0.39333190
88	MP0001270_distended_abdomen	0.38067594
89	MP0000749_muscle_degeneration	0.37939516
90	MP0000313_abnormal_cell_death	0.37617615
91	MP0002108_abnormal_muscle_morphology	0.36379578
92	MP0004484_altered_response_of	0.36097606
93	MP0005408_hypopigmentation	0.34756251
94	MP0002109_abnormal_limb_morphology	0.34702317
95	MP0002733_abnormal_thermal_nociception	0.34575586
96	MP0002971_abnormal_brown_adipose	0.32675397
97	MP0005167_abnormal_blood-brain_barrier	0.32575410
98	MP0009697_abnormal_copulation	0.32210707
99	MP0002114_abnormal_axial_skeleton	0.31801801
100	MP0005623_abnormal_meninges_morphology	0.31436433

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.64875659
2	Asymmetric septal hypertrophy (HP:0001670)	5.04105716
3	Bell-shaped thorax (HP:0001591)	4.97093912
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.84906776
5	Absent/shortened dynein arms (HP:0200106)	4.84906776
6	Hypoplastic ischia (HP:0003175)	4.63524316
7	Resting tremor (HP:0002322)	4.63210512
8	Hyperkalemia (HP:0002153)	4.47897257
9	Bony spicule pigmentary retinopathy (HP:0007737)	4.42500326
10	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.42316661
11	Male infertility (HP:0003251)	4.36944083
12	Attenuation of retinal blood vessels (HP:0007843)	4.24154492
13	Tubulointerstitial nephritis (HP:0001970)	4.14515930
14	Abnormality of the ischium (HP:0003174)	4.01761240
15	Azoospermia (HP:0000027)	3.95568731
16	Enlarged epiphyses (HP:0010580)	3.89360543
17	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.88828290
18	Infertility (HP:0000789)	3.86807782
19	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.81715258
20	Abnormal spermatogenesis (HP:0008669)	3.66106421
21	Potter facies (HP:0002009)	3.65348674
22	Facial shape deformation (HP:0011334)	3.65348674
23	Nasal polyposis (HP:0100582)	3.50841622
24	Abnormal ciliary motility (HP:0012262)	3.50136075
25	Abnormal respiratory motile cilium physiology (HP:0012261)	3.37234984
26	Abnormal respiratory motile cilium morphology (HP:0005938)	3.32630736
27	Abnormal respiratory epithelium morphology (HP:0012253)	3.32630736
28	Abnormal rod and cone electroretinograms (HP:0008323)	3.23216193
29	Abnormality of macular pigmentation (HP:0008002)	3.21841713
30	Unilateral renal agenesis (HP:0000122)	3.17191801
31	Impulsivity (HP:0100710)	3.02199549
32	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	3.00685027
33	Absent epiphyses (HP:0010577)	3.00685027
34	Abnormality of the aortic arch (HP:0012303)	2.97859258
35	Flattened epiphyses (HP:0003071)	2.85813884
36	Chronic hepatic failure (HP:0100626)	2.83918960
37	Double outlet right ventricle (HP:0001719)	2.75874327
38	Congenital malformation of the right heart (HP:0011723)	2.75874327
39	Abnormality of the nasal mucosa (HP:0000433)	2.73830043
40	Horizontal nystagmus (HP:0000666)	2.73368480
41	Cone-rod dystrophy (HP:0000548)	2.68827318
42	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.67950796
43	Postural instability (HP:0002172)	2.67763627
44	Epiphyseal dysplasia (HP:0002656)	2.64247814
45	Bowel incontinence (HP:0002607)	2.64170221
46	Hyperthyroidism (HP:0000836)	2.59260083
47	Abnormality of the costochondral junction (HP:0000919)	2.55869751
48	Atelectasis (HP:0100750)	2.55166259
49	Renal dysplasia (HP:0000110)	2.53779704
50	Truncal obesity (HP:0001956)	2.50956702
51	Ventricular tachycardia (HP:0004756)	2.46157242
52	Peripheral hypomyelination (HP:0007182)	2.45503467
53	Abnormality of the parathyroid morphology (HP:0011766)	2.45331026
54	Abnormal large intestine physiology (HP:0012700)	2.43787333
55	Hypoplasia of the thymus (HP:0000778)	2.43070430
56	Abnormality of potassium homeostasis (HP:0011042)	2.37588610
57	Hypoparathyroidism (HP:0000829)	2.36736316
58	Generalized aminoaciduria (HP:0002909)	2.33540416
59	Osteomalacia (HP:0002749)	2.32662790
60	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.27935830
61	Flat capital femoral epiphysis (HP:0003370)	2.27237575
62	Progressive sensorineural hearing impairment (HP:0000408)	2.26641597
63	Abnormal urine output (HP:0012590)	2.25679176
64	Stage 5 chronic kidney disease (HP:0003774)	2.25621911
65	Protuberant abdomen (HP:0001538)	2.23728651
66	Hypoalphalipoproteinemia (HP:0003233)	2.21269489
67	Abnormality of the pubic bones (HP:0003172)	2.18261683
68	Spastic paraparesis (HP:0002313)	2.12862342
69	Hyponatremia (HP:0002902)	2.12165680
70	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	2.10576768
71	Abnormality of femoral epiphyses (HP:0006499)	2.10576768
72	Nephronophthisis (HP:0000090)	2.08245345
73	Widely patent fontanelles and sutures (HP:0004492)	2.05079165
74	Truncus arteriosus (HP:0001660)	2.04840939
75	Amelogenesis imperfecta (HP:0000705)	2.04185873
76	Vertebral clefting (HP:0008428)	2.02485318
77	Abnormality of the femoral head (HP:0003368)	2.01293598
78	Menstrual irregularities (HP:0000858)	1.98205695
79	Abnormality of renal excretion (HP:0011036)	1.95942132
80	Abnormal ventriculo-arterial connection (HP:0011563)	1.93677580
81	Transposition of the great arteries (HP:0001669)	1.93677580
82	Abnormal connection of the cardiac segments (HP:0011545)	1.93677580
83	Short ribs (HP:0000773)	1.93004775
84	Insulin-resistant diabetes mellitus (HP:0000831)	1.89718552
85	Upper limb muscle weakness (HP:0003484)	1.88507267
86	Hand muscle atrophy (HP:0009130)	1.83504508
87	Rhabdomyolysis (HP:0003201)	1.80823608
88	Delayed epiphyseal ossification (HP:0002663)	1.80701315
89	Obsessive-compulsive behavior (HP:0000722)	1.79255941
90	Abnormality of chloride homeostasis (HP:0011422)	1.78922353
91	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.77608531
92	Abnormality of the renal medulla (HP:0100957)	1.77300410
93	Mixed hearing impairment (HP:0000410)	1.77037115
94	Underdeveloped nasal alae (HP:0000430)	1.76601454
95	Hypophosphatemic rickets (HP:0004912)	1.76441566
96	Renovascular hypertension (HP:0100817)	1.76021493
97	Abnormality of dental color (HP:0011073)	1.75679546
98	Glossoptosis (HP:0000162)	1.74703520
99	Recurrent corneal erosions (HP:0000495)	1.74135060
100	Sandal gap (HP:0001852)	1.73733275

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.22216196
2	TESK1	5.80380424
3	DDR2	5.22636539
4	PNCK	4.89375473
5	CAMK1G	2.96567417
6	STK38	2.87166305
7	INSRR	2.81913824
8	MST1R	2.72995804
9	CDK12	2.68480722
10	MAP4K2	2.63988579
11	PLK2	2.58618039
12	BRD4	2.36902524
13	MAPK15	2.34181986
14	PRKD3	2.27850818
15	MET	2.23046552
16	WNK1	2.02390542
17	STK38L	1.88116112
18	PTK2B	1.65336808
19	PDPK1	1.59104509
20	CDK7	1.56624552
21	KSR2	1.55219901
22	PDK1	1.31405803
23	LATS2	1.22928994
24	MAP3K2	1.10608667
25	MAP3K9	1.08281685
26	DYRK1B	1.05557918
27	NEK6	0.99136818
28	CAMK1D	0.92806348
29	AKT3	0.91311881
30	PIK3CG	0.90307223
31	BRAF	0.83871462
32	BMX	0.81972801
33	SIK2	0.80439215
34	TYRO3	0.79404634
35	CDK19	0.78709711
36	MAP2K2	0.73296056
37	WNK4	0.73103687
38	MTOR	0.70320856
39	LATS1	0.65976965
40	CDK4	0.64690979
41	MAP3K8	0.62046005
42	CHEK1	0.61950139
43	RPS6KA2	0.60192102
44	PRKAA2	0.59456997
45	PRKG2	0.57886946
46	RPS6KA1	0.57206767
47	ROCK1	0.56317395
48	MAP3K13	0.55997391
49	CDK2	0.55814984
50	TRIB3	0.55530715
51	LMTK2	0.54268966
52	UHMK1	0.53978936
53	CDK1	0.52296873
54	ICK	0.50611956
55	PRKG1	0.49068124
56	GSK3B	0.46822711
57	EEF2K	0.45268858
58	MAP3K1	0.44631234
59	RIPK1	0.44150680
60	MAP3K11	0.42816217
61	MAPK1	0.41865885
62	TESK2	0.39857548
63	CDK3	0.38763270
64	RPS6KL1	0.38163948
65	RPS6KC1	0.38163948
66	RET	0.37403518
67	OXSR1	0.37309971
68	ARAF	0.36863025
69	CAMK1	0.35558059
70	SGK1	0.34626566
71	MAPK8	0.32100954
72	RPS6KA6	0.31030142
73	MAPK14	0.27669440
74	NEK2	0.27666440
75	MAPK10	0.26001942
76	MAPK11	0.24105106
77	MARK2	0.23306344
78	STK39	0.22442398
79	DYRK3	0.21472808
80	NTRK3	0.20176622
81	PDGFRB	0.20044637
82	MUSK	0.19725990
83	BRSK1	0.19716297
84	PRKCZ	0.19611006
85	CDK11A	0.18989269
86	EPHA2	0.18852743
87	PTK2	0.18804099
88	PRKAA1	0.18683608
89	AKT1	0.18046346
90	SGK494	0.15597366
91	SGK223	0.15597366
92	PDGFRA	0.14960021
93	CAMK4	0.13812477
94	PLK1	0.13581279
95	TRPM7	0.13369331
96	MAP2K1	0.11570303
97	FGR	0.10671499
98	PHKG1	0.07962142
99	PHKG2	0.07962142
100	AURKA	0.07756812

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.08160479
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.85148667
3	Olfactory transduction_Homo sapiens_hsa04740	3.17015708
4	RNA transport_Homo sapiens_hsa03013	2.28296140
5	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.08681806
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.08417754
7	Butanoate metabolism_Homo sapiens_hsa00650	1.99351063
8	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.83361327
9	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.81206076
10	Arginine and proline metabolism_Homo sapiens_hsa00330	1.76774268
11	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.75936854
12	Type II diabetes mellitus_Homo sapiens_hsa04930	1.69316454
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.68302805
14	Phenylalanine metabolism_Homo sapiens_hsa00360	1.63046806
15	Taste transduction_Homo sapiens_hsa04742	1.57719278
16	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.52976906
17	Protein digestion and absorption_Homo sapiens_hsa04974	1.49879466
18	Fatty acid metabolism_Homo sapiens_hsa01212	1.49741617
19	Oocyte meiosis_Homo sapiens_hsa04114	1.46860543
20	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.44552423
21	Fatty acid degradation_Homo sapiens_hsa00071	1.43088941
22	mRNA surveillance pathway_Homo sapiens_hsa03015	1.40747221
23	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.39060173
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.29259685
25	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.26268173
26	Endocytosis_Homo sapiens_hsa04144	1.25243703
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.19302282
28	Antigen processing and presentation_Homo sapiens_hsa04612	1.17823244
29	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.11073595
30	VEGF signaling pathway_Homo sapiens_hsa04370	1.09409376
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.02182848
32	Acute myeloid leukemia_Homo sapiens_hsa05221	1.01392268
33	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.97522651
34	Viral myocarditis_Homo sapiens_hsa05416	0.94623212
35	Selenocompound metabolism_Homo sapiens_hsa00450	0.94400672
36	Estrogen signaling pathway_Homo sapiens_hsa04915	0.92177525
37	Sulfur relay system_Homo sapiens_hsa04122	0.87487212
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.82589933
39	Renin-angiotensin system_Homo sapiens_hsa04614	0.80934727
40	Type I diabetes mellitus_Homo sapiens_hsa04940	0.78151610
41	Allograft rejection_Homo sapiens_hsa05330	0.77600694
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.77448445
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.77373776
44	ABC transporters_Homo sapiens_hsa02010	0.76508440
45	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.75874235
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.75133319
47	Lysine degradation_Homo sapiens_hsa00310	0.73593468
48	Influenza A_Homo sapiens_hsa05164	0.73369371
49	PPAR signaling pathway_Homo sapiens_hsa03320	0.73175864
50	Basal transcription factors_Homo sapiens_hsa03022	0.69339679
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64206967
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.63287192
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.61642750
54	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.61614048
55	Insulin signaling pathway_Homo sapiens_hsa04910	0.60618561
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.60593327
57	Tight junction_Homo sapiens_hsa04530	0.60410673
58	ErbB signaling pathway_Homo sapiens_hsa04012	0.60221248
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.59410609
60	MAPK signaling pathway_Homo sapiens_hsa04010	0.56661863
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55779969
62	Viral carcinogenesis_Homo sapiens_hsa05203	0.55260223
63	Adherens junction_Homo sapiens_hsa04520	0.53990473
64	mTOR signaling pathway_Homo sapiens_hsa04150	0.52652954
65	cAMP signaling pathway_Homo sapiens_hsa04024	0.52347549
66	Salivary secretion_Homo sapiens_hsa04970	0.51311176
67	Prolactin signaling pathway_Homo sapiens_hsa04917	0.48401754
68	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.48236273
69	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47064114
70	ECM-receptor interaction_Homo sapiens_hsa04512	0.46843143
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.45718057
72	Purine metabolism_Homo sapiens_hsa00230	0.45482794
73	Cell cycle_Homo sapiens_hsa04110	0.43713987
74	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.43668534
75	Phototransduction_Homo sapiens_hsa04744	0.43261016
76	Choline metabolism in cancer_Homo sapiens_hsa05231	0.42002949
77	Prostate cancer_Homo sapiens_hsa05215	0.41549951
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41523909
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.39831133
80	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38875464
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.37476646
82	Insulin resistance_Homo sapiens_hsa04931	0.37277431
83	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.37203562
84	Bile secretion_Homo sapiens_hsa04976	0.36717917
85	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.34951556
86	Carbon metabolism_Homo sapiens_hsa01200	0.34261872
87	Base excision repair_Homo sapiens_hsa03410	0.33264659
88	Pancreatic secretion_Homo sapiens_hsa04972	0.31782120
89	Circadian rhythm_Homo sapiens_hsa04710	0.31059597
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.30753815
91	Retinol metabolism_Homo sapiens_hsa00830	0.30717045
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.28393228
93	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.27012710
94	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.25313038
95	Non-small cell lung cancer_Homo sapiens_hsa05223	0.24497506
96	Focal adhesion_Homo sapiens_hsa04510	0.24384219
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.22926370
98	Glucagon signaling pathway_Homo sapiens_hsa04922	0.22675941
99	Notch signaling pathway_Homo sapiens_hsa04330	0.21253090
100	Bladder cancer_Homo sapiens_hsa05219	0.21200436

SLC6A10P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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