SLC6A12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.33815211
2L-phenylalanine catabolic process (GO:0006559)7.33815211
3L-phenylalanine metabolic process (GO:0006558)6.99975484
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.99975484
5aromatic amino acid family catabolic process (GO:0009074)6.65228791
6epoxygenase P450 pathway (GO:0019373)6.49353298
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.24879751
8tryptophan catabolic process (GO:0006569)6.04286540
9indole-containing compound catabolic process (GO:0042436)6.04286540
10indolalkylamine catabolic process (GO:0046218)6.04286540
11omega-hydroxylase P450 pathway (GO:0097267)6.00875181
12kynurenine metabolic process (GO:0070189)5.92086111
13exogenous drug catabolic process (GO:0042738)5.78894551
14bile acid biosynthetic process (GO:0006699)5.74206284
15tryptophan metabolic process (GO:0006568)5.69781730
16urea metabolic process (GO:0019627)5.55554578
17urea cycle (GO:0000050)5.55554578
18glyoxylate metabolic process (GO:0046487)5.52133339
19high-density lipoprotein particle remodeling (GO:0034375)5.51590007
20negative regulation of fibrinolysis (GO:0051918)5.48688467
21regulation of protein activation cascade (GO:2000257)5.44142694
22protein carboxylation (GO:0018214)5.42225918
23peptidyl-glutamic acid carboxylation (GO:0017187)5.42225918
24alpha-linolenic acid metabolic process (GO:0036109)5.40811767
25regulation of fibrinolysis (GO:0051917)5.28012100
26cysteine metabolic process (GO:0006534)5.26426571
27sulfur amino acid catabolic process (GO:0000098)5.19357440
28complement activation, alternative pathway (GO:0006957)5.13162359
29regulation of complement activation (GO:0030449)5.12591488
30nitrogen cycle metabolic process (GO:0071941)5.10226934
31serine family amino acid catabolic process (GO:0009071)4.93849313
32bile acid metabolic process (GO:0008206)4.92918081
33reverse cholesterol transport (GO:0043691)4.81369982
34aromatic amino acid family metabolic process (GO:0009072)4.80995824
35regulation of cholesterol esterification (GO:0010872)4.78185864
36macromolecular complex remodeling (GO:0034367)4.72892296
37plasma lipoprotein particle remodeling (GO:0034369)4.72892296
38protein-lipid complex remodeling (GO:0034368)4.72892296
39regulation of triglyceride catabolic process (GO:0010896)4.69501363
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.68080130
41tyrosine metabolic process (GO:0006570)4.67143752
42homocysteine metabolic process (GO:0050667)4.62391543
43triglyceride homeostasis (GO:0070328)4.52492008
44acylglycerol homeostasis (GO:0055090)4.52492008
45plasma lipoprotein particle clearance (GO:0034381)4.51272077
46phospholipid efflux (GO:0033700)4.48602062
47negative regulation of cholesterol transport (GO:0032375)4.48571999
48negative regulation of sterol transport (GO:0032372)4.48571999
49alpha-amino acid catabolic process (GO:1901606)4.46600740
50amino-acid betaine metabolic process (GO:0006577)4.40560705
51lysine metabolic process (GO:0006553)4.38722221
52lysine catabolic process (GO:0006554)4.38722221
53cellular glucuronidation (GO:0052695)4.34855381
54bile acid and bile salt transport (GO:0015721)4.28781552
55indolalkylamine metabolic process (GO:0006586)4.26657405
56fibrinolysis (GO:0042730)4.24182911
57drug metabolic process (GO:0017144)4.23737676
58cellular biogenic amine catabolic process (GO:0042402)4.23228747
59amine catabolic process (GO:0009310)4.23228747
60cholesterol efflux (GO:0033344)4.20382459
61cellular ketone body metabolic process (GO:0046950)4.20252688
62glycine metabolic process (GO:0006544)4.20208991
63negative regulation of protein activation cascade (GO:2000258)4.19731175
64imidazole-containing compound metabolic process (GO:0052803)4.19158849
65aldehyde catabolic process (GO:0046185)4.15887763
66coenzyme catabolic process (GO:0009109)4.13006832
67cellular amino acid catabolic process (GO:0009063)4.09710725
68benzene-containing compound metabolic process (GO:0042537)4.08953507
69blood coagulation, intrinsic pathway (GO:0007597)4.07889374
70ethanol metabolic process (GO:0006067)4.07424657
71glutamate metabolic process (GO:0006536)4.07147425
72serine family amino acid metabolic process (GO:0009069)3.99994190
73low-density lipoprotein particle remodeling (GO:0034374)3.98903095
74plasma lipoprotein particle assembly (GO:0034377)3.94252681
75cellular modified amino acid catabolic process (GO:0042219)3.93780371
76arginine metabolic process (GO:0006525)3.93450608
77response to mercury ion (GO:0046689)3.93081641
78glucuronate metabolic process (GO:0019585)3.91947716
79uronic acid metabolic process (GO:0006063)3.91947716
80dicarboxylic acid biosynthetic process (GO:0043650)3.91812398
81sodium-independent organic anion transport (GO:0043252)3.87964680
82ethanol oxidation (GO:0006069)3.86110163
83drug catabolic process (GO:0042737)3.85378898
84serine family amino acid biosynthetic process (GO:0009070)3.84321963
85cofactor catabolic process (GO:0051187)3.77609712
86positive regulation of triglyceride lipase activity (GO:0061365)3.76789028
87positive regulation of lipoprotein lipase activity (GO:0051006)3.76789028
88protein activation cascade (GO:0072376)3.76697177
89oxidative demethylation (GO:0070989)3.72119096
90complement activation, classical pathway (GO:0006958)3.70532466
91complement activation (GO:0006956)3.69756976
92cholesterol homeostasis (GO:0042632)3.68238394
93phospholipid homeostasis (GO:0055091)3.67983685
94positive regulation of lipid catabolic process (GO:0050996)3.67902085
95very-low-density lipoprotein particle assembly (GO:0034379)3.66217664
96* gamma-aminobutyric acid transport (GO:0015812)3.65238344
97sterol homeostasis (GO:0055092)3.62707940
98ketone body metabolic process (GO:1902224)3.62433769
99plasma lipoprotein particle organization (GO:0071827)3.61783448
100negative regulation of lipase activity (GO:0060192)3.59104861
101opsonization (GO:0008228)3.58064689
102organic acid catabolic process (GO:0016054)3.57575107
103carboxylic acid catabolic process (GO:0046395)3.57575107
104protein-lipid complex assembly (GO:0065005)3.54740229
105NAD biosynthetic process (GO:0009435)3.53609174
106regulation of cholesterol homeostasis (GO:2000188)3.51709655
107regulation of bile acid biosynthetic process (GO:0070857)3.51608718
108acute-phase response (GO:0006953)3.51454718
109phenylpropanoid metabolic process (GO:0009698)3.50594933
110regulation of humoral immune response (GO:0002920)3.50386673
111nicotinamide nucleotide biosynthetic process (GO:0019359)3.49560168
112regulation of plasminogen activation (GO:0010755)3.47546145
113S-adenosylmethionine metabolic process (GO:0046500)3.31558858
114negative regulation of blood coagulation (GO:0030195)3.30613947
115negative regulation of hemostasis (GO:1900047)3.30613947
116alkaloid metabolic process (GO:0009820)3.28446872
117disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.15695884
118killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.15695884
119steroid catabolic process (GO:0006706)3.07025087
120negative regulation of complement activation (GO:0045916)3.02668615
121positive regulation of blood coagulation (GO:0030194)3.02666740
122positive regulation of hemostasis (GO:1900048)3.02666740
123positive regulation of fatty acid biosynthetic process (GO:0045723)2.98788499
124negative regulation of coagulation (GO:0050819)2.98619977
125hydrogen peroxide biosynthetic process (GO:0050665)2.93611013
126positive regulation of coagulation (GO:0050820)2.92660046
127fat-soluble vitamin biosynthetic process (GO:0042362)2.89838045
128negative regulation of wound healing (GO:0061045)2.81719021
129cytolysis (GO:0019835)2.78206354
130indole-containing compound metabolic process (GO:0042430)2.77885657
131acute inflammatory response (GO:0002526)2.73302790
132regulation of acute inflammatory response (GO:0002673)2.72874691
133heme transport (GO:0015886)2.72422095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.15991013
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.98577527
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.89302552
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.33068832
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.08231788
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.00836690
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.69873062
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89515789
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.86090511
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.22390035
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5797999
12* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.96122732
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95284676
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89537514
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89264684
16DROSHA_22980978_ChIP-Seq_HELA_Human1.63659410
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.58098769
18CLOCK_20551151_ChIP-Seq_293T_Human1.57714681
19* FOXA2_19822575_ChIP-Seq_HepG2_Human1.51130520
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49419768
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46254318
22HTT_18923047_ChIP-ChIP_STHdh_Human1.45222983
23GATA1_22025678_ChIP-Seq_K562_Human1.44718041
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39667377
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39363972
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37809711
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37280064
28* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33187989
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20501307
30RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20366162
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17835719
32REST_21632747_ChIP-Seq_MESCs_Mouse1.16348610
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15579367
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14233503
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11672970
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11611063
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07449135
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06065781
39VDR_24787735_ChIP-Seq_THP-1_Human1.05452065
40* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05115968
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04661114
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02189723
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01431718
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00253322
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96676474
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96442816
47ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95105678
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94263097
49IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93983666
50* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92809512
51REST_18959480_ChIP-ChIP_MESCs_Mouse0.92045807
52ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90372418
53SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89991170
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88412714
55ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88301203
56* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87538142
57EZH2_27294783_Chip-Seq_ESCs_Mouse0.87310204
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.86992296
59GATA4_25053715_ChIP-Seq_YYC3_Human0.85750197
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84690074
61GATA2_21666600_ChIP-Seq_HMVEC_Human0.84411014
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82759831
63CTCF_20526341_ChIP-Seq_ESCs_Human0.81384655
64GBX2_23144817_ChIP-Seq_PC3_Human0.81288654
65RUNX_20019798_ChIP-Seq_JUKART_Human0.81097898
66OCT4_20526341_ChIP-Seq_ESCs_Human0.80377951
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79753227
68NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79753227
69* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79544130
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78924459
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78583270
72SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78092092
73BCL6_27268052_Chip-Seq_Bcells_Human0.77739576
74MYC_19829295_ChIP-Seq_ESCs_Human0.77454450
75SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77403708
76SPI1_23127762_ChIP-Seq_K562_Human0.76220939
77ESR2_21235772_ChIP-Seq_MCF-7_Human0.76078380
78KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75602845
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.75524210
80RAC3_21632823_ChIP-Seq_H3396_Human0.74700724
81SA1_27219007_Chip-Seq_Bcells_Human0.74586411
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74063097
83BCOR_27268052_Chip-Seq_Bcells_Human0.73631237
84JARID2_20064375_ChIP-Seq_MESCs_Mouse0.73449984
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.73345811
86RARA_24833708_ChIP-Seq_LIVER_Mouse0.72711454
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72621369
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72443441
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.70956742
90SMC4_20622854_ChIP-Seq_HELA_Human0.70801917
91JARID2_20075857_ChIP-Seq_MESCs_Mouse0.70132445
92EZH2_22144423_ChIP-Seq_EOC_Human0.69971123
93SCL_19346495_ChIP-Seq_HPC-7_Human0.69759994
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.69738336
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69637273
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.69520174
97OCT4_19829295_ChIP-Seq_ESCs_Human0.69196891
98BCAT_22108803_ChIP-Seq_LS180_Human0.69035576
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68941860
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68393180
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67179480
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66761213
103SOX2_19829295_ChIP-Seq_ESCs_Human0.66609254
104NANOG_19829295_ChIP-Seq_ESCs_Human0.66609254
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66210232
106FOXH1_21741376_ChIP-Seq_EPCs_Human0.65825348
107IRF8_27001747_Chip-Seq_BMDM_Mouse0.64970465
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.64679031
109IRF8_21731497_ChIP-ChIP_J774_Mouse0.63642598
110RARB_24833708_ChIP-Seq_LIVER_Mouse0.62997796
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62709755
112LXR_22292898_ChIP-Seq_THP-1_Human0.60442227
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60115798
114ZNF263_19887448_ChIP-Seq_K562_Human0.59067670
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.57833377
116CEBPB_22108803_ChIP-Seq_LS180_Human0.57181643
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.56646722
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55118010
119MYC_19915707_ChIP-ChIP_AK7_Human0.53360502
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53153777
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52354925
122AR_20517297_ChIP-Seq_VCAP_Human0.51795484
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.51709948
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.51538793
125GATA1_19941826_ChIP-Seq_K562_Human0.51040414
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50869956
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49677813
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.49652581
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.49469393
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48369903
131* EGR1_19032775_ChIP-ChIP_M12_Human0.48262437
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47445298
133STAT1_17558387_ChIP-Seq_HELA_Human0.47214612
134SOX2_20726797_ChIP-Seq_SW620_Human0.47163718
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46661830
136CBP_21632823_ChIP-Seq_H3396_Human0.46434934
137GATA2_19941826_ChIP-Seq_K562_Human0.46013599
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.45950468
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45596646
140* ESET_19884257_ChIP-Seq_ESCs_Mouse0.45489843
141P53_21459846_ChIP-Seq_SAOS-2_Human0.44842531
142FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.44045955
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43976555
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.43288653
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42859328
146GATA6_25053715_ChIP-Seq_YYC3_Human0.42296151
147CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.41823472
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.41611187
149* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.40748378
150* TAF2_19829295_ChIP-Seq_ESCs_Human0.40008518
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39967197
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.39935408
153CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.39361725
154PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.39293354
155CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.38488072
156TRIM28_21343339_ChIP-Seq_HEK293_Human0.37947712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.06618439
2MP0005360_urolithiasis7.34598865
3MP0005085_abnormal_gallbladder_physiolo6.19908223
4MP0005365_abnormal_bile_salt5.88812544
5MP0008875_abnormal_xenobiotic_pharmacok5.01391389
6MP0003806_abnormal_nucleotide_metabolis4.15527500
7MP0003252_abnormal_bile_duct3.73888333
8MP0010329_abnormal_lipoprotein_level3.52777364
9MP0009840_abnormal_foam_cell3.52291725
10MP0003195_calcinosis3.10258765
11MP0005083_abnormal_biliary_tract3.04827720
12MP0005332_abnormal_amino_acid2.68891593
13MP0003191_abnormal_cellular_cholesterol2.45786046
14MP0001666_abnormal_nutrient_absorption2.45590815
15MP0000609_abnormal_liver_physiology2.14446049
16MP0004019_abnormal_vitamin_homeostasis2.04637581
17MP0002118_abnormal_lipid_homeostasis2.04540910
18MP0002138_abnormal_hepatobiliary_system1.90922959
19MP0005319_abnormal_enzyme/_coenzyme1.86267455
20MP0003868_abnormal_feces_composition1.75660039
21MP0003879_abnormal_hair_cell1.72649469
22MP0003303_peritoneal_inflammation1.70656060
23MP0001764_abnormal_homeostasis1.62736867
24MP0005584_abnormal_enzyme/coenzyme_acti1.58471739
25MP0009697_abnormal_copulation1.57415379
26MP0005451_abnormal_body_composition1.48192613
27MP0003186_abnormal_redox_activity1.40913970
28MP0004043_abnormal_pH_regulation1.39948783
29MP0003011_delayed_dark_adaptation1.39671192
30MP0003656_abnormal_erythrocyte_physiolo1.39201489
31MP0000604_amyloidosis1.33563856
32MP0001501_abnormal_sleep_pattern1.33000972
33MP0000920_abnormal_myelination1.28794764
34MP0003183_abnormal_peptide_metabolism1.28441352
35MP0002148_abnormal_hypersensitivity_rea1.28331203
36MP0009764_decreased_sensitivity_to1.27302150
37MP0009643_abnormal_urine_homeostasis1.27042904
38MP0004859_abnormal_synaptic_plasticity1.22530563
39MP0009745_abnormal_behavioral_response1.21162792
40MP0002064_seizures1.20656569
41MP0001835_abnormal_antigen_presentation1.20175495
42MP0003705_abnormal_hypodermis_morpholog1.19312723
43MP0000598_abnormal_liver_morphology1.18496682
44MP0002254_reproductive_system_inflammat1.10445176
45MP0002132_abnormal_respiratory_system1.09492592
46MP0009763_increased_sensitivity_to1.09350304
47MP0008469_abnormal_protein_level1.06586049
48MP0005671_abnormal_response_to1.02772761
49MP0005647_abnormal_sex_gland1.02303260
50MP0003633_abnormal_nervous_system1.01934651
51MP0000685_abnormal_immune_system0.98805685
52MP0001986_abnormal_taste_sensitivity0.97959660
53MP0010386_abnormal_urinary_bladder0.95906334
54MP0005000_abnormal_immune_tolerance0.94523511
55MP0005636_abnormal_mineral_homeostasis0.94180553
56MP0001486_abnormal_startle_reflex0.91918860
57MP0005387_immune_system_phenotype0.90760475
58MP0001790_abnormal_immune_system0.90760475
59MP0005646_abnormal_pituitary_gland0.90422931
60MP0010368_abnormal_lymphatic_system0.88847316
61MP0009642_abnormal_blood_homeostasis0.88609526
62MP0003436_decreased_susceptibility_to0.87281028
63MP0005376_homeostasis/metabolism_phenot0.85377692
64MP0005408_hypopigmentation0.84631559
65MP0003631_nervous_system_phenotype0.83692952
66MP0003880_abnormal_central_pattern0.82269224
67MP0002063_abnormal_learning/memory/cond0.80951143
68MP0001800_abnormal_humoral_immune0.80917862
69MP0003635_abnormal_synaptic_transmissio0.79755014
70MP0002723_abnormal_immune_serum0.79681897
71MP0009765_abnormal_xenobiotic_induced0.79352713
72MP0005464_abnormal_platelet_physiology0.77317249
73MP0002572_abnormal_emotion/affect_behav0.75524493
74MP0004270_analgesia0.75148899
75MP0005670_abnormal_white_adipose0.74991189
76MP0002272_abnormal_nervous_system0.74905689
77MP0003690_abnormal_glial_cell0.74761100
78MP0003632_abnormal_nervous_system0.72541856
79MP0006082_CNS_inflammation0.72367592
80MP0002078_abnormal_glucose_homeostasis0.72000241
81MP0005058_abnormal_lysosome_morphology0.71755691
82MP0006036_abnormal_mitochondrial_physio0.71617586
83MP0008569_lethality_at_weaning0.70653227
84MP0003724_increased_susceptibility_to0.69032433
85MP0002971_abnormal_brown_adipose0.68821994
86MP0004130_abnormal_muscle_cell0.67508924
87MP0002452_abnormal_antigen_presenting0.67410893
88MP0005535_abnormal_body_temperature0.67157707
89MP0001756_abnormal_urination0.66313999
90MP0005084_abnormal_gallbladder_morpholo0.65922073
91MP0001440_abnormal_grooming_behavior0.65131504
92MP0002876_abnormal_thyroid_physiology0.65063932
93MP0005423_abnormal_somatic_nervous0.64964693
94MP0005334_abnormal_fat_pad0.64577945
95MP0009046_muscle_twitch0.63964772
96MP0005266_abnormal_metabolism0.63554421
97MP0002837_dystrophic_cardiac_calcinosis0.61525630
98MP0003075_altered_response_to0.60581042
99MP0005220_abnormal_exocrine_pancreas0.59777303
100MP0000639_abnormal_adrenal_gland0.59456017
101MP0005397_hematopoietic_system_phenotyp0.58687231
102MP0001661_extended_life_span0.57938507
103MP0003329_amyloid_beta_deposits0.57742510
104MP0009053_abnormal_anal_canal0.55492733
105MP0002136_abnormal_kidney_physiology0.54916466
106MP0005166_decreased_susceptibility_to0.53983878
107MP0009785_altered_susceptibility_to0.53524924
108MP0004782_abnormal_surfactant_physiolog0.51008509
109MP0005164_abnormal_response_to0.50473915
110MP0008873_increased_physiological_sensi0.50047715
111MP0005448_abnormal_energy_balance0.49869935
112MP0003638_abnormal_response/metabolism_0.49215010
113MP0001845_abnormal_inflammatory_respons0.47674633
114MP0005395_other_phenotype0.46579572
115MP0005167_abnormal_blood-brain_barrier0.46101600
116MP0002419_abnormal_innate_immunity0.45995568
117MP0006035_abnormal_mitochondrial_morpho0.45856614
118MP0008874_decreased_physiological_sensi0.45652827
119MP0000249_abnormal_blood_vessel0.45532229
120MP0004883_abnormal_blood_vessel0.43461133
121MP0001853_heart_inflammation0.42251227
122MP0001533_abnormal_skeleton_physiology0.40040706
123MP0003718_maternal_effect0.39316645
124MP0005248_abnormal_Harderian_gland0.37065856
125MP0005025_abnormal_response_to0.36949574
126MP0003953_abnormal_hormone_level0.36504404
127MP0005666_abnormal_adipose_tissue0.34973069
128MP0001243_abnormal_dermal_layer0.34913068
129MP0002090_abnormal_vision0.33569603
130MP0009115_abnormal_fat_cell0.33046128
131MP0002168_other_aberrant_phenotype0.32688812
132MP0003172_abnormal_lysosome_physiology0.31716965
133MP0002928_abnormal_bile_duct0.31566857
134MP0004947_skin_inflammation0.30945458
135MP0000230_abnormal_systemic_arterial0.29776395
136MP0001542_abnormal_bone_strength0.28769378
137MP0005023_abnormal_wound_healing0.28340896
138MP0008872_abnormal_physiological_respon0.27547255

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.30203800
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.23301050
3Intrahepatic cholestasis (HP:0001406)7.10392039
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.51505465
5Prolonged partial thromboplastin time (HP:0003645)6.46520714
6Hypobetalipoproteinemia (HP:0003563)6.22890643
7Xanthomatosis (HP:0000991)6.22367185
8Hyperlipoproteinemia (HP:0010980)5.54561955
9Complement deficiency (HP:0004431)5.09127481
10Joint hemorrhage (HP:0005261)4.89975360
11Hypolipoproteinemia (HP:0010981)4.74542938
12Abnormality of the common coagulation pathway (HP:0010990)4.51840158
13Hyperammonemia (HP:0001987)4.39964019
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.32445653
15Epidermoid cyst (HP:0200040)4.30163576
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.25422994
17Hypoalphalipoproteinemia (HP:0003233)4.22674394
18Abnormality of methionine metabolism (HP:0010901)4.20770215
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.18038526
20Hyperglycinemia (HP:0002154)4.09109698
21Fat malabsorption (HP:0002630)4.02143826
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.00670079
23Ketosis (HP:0001946)3.99108960
24Abnormality of the intrinsic pathway (HP:0010989)3.80188973
25Abnormality of complement system (HP:0005339)3.77008824
26Conjugated hyperbilirubinemia (HP:0002908)3.69908918
27Abnormality of pyrimidine metabolism (HP:0004353)3.69753805
28Hyperglycinuria (HP:0003108)3.64407736
29Hypoglycemic coma (HP:0001325)3.64046153
30Abnormality of serine family amino acid metabolism (HP:0010894)3.63455588
31Abnormality of glycine metabolism (HP:0010895)3.63455588
32Increased circulating renin level (HP:0000848)3.61426865
33Hypercholesterolemia (HP:0003124)3.57814903
34Systemic lupus erythematosus (HP:0002725)3.44894215
35Increased serum ferritin (HP:0003281)3.33725159
36Abnormality of fatty-acid metabolism (HP:0004359)3.28181018
37Hyperbilirubinemia (HP:0002904)3.25248791
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22292962
39Metabolic alkalosis (HP:0200114)3.21960897
40Myocardial infarction (HP:0001658)3.17957469
41Abnormality of macrophages (HP:0004311)3.14112512
42Steatorrhea (HP:0002570)3.06164501
43Hypokalemic alkalosis (HP:0001949)3.05582392
44Abnormality of nucleobase metabolism (HP:0010932)3.03346365
45Spontaneous abortion (HP:0005268)2.94905407
46Delayed CNS myelination (HP:0002188)2.93288797
47Hepatocellular carcinoma (HP:0001402)2.93217663
48Abnormality of serum amino acid levels (HP:0003112)2.87508765
49Recurrent gram-negative bacterial infections (HP:0005420)2.85428911
50Abnormality of liposaccharide metabolism (HP:0010968)2.76219771
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.76219771
52Abnormality of glycolipid metabolism (HP:0010969)2.76219771
53Ketoacidosis (HP:0001993)2.72542144
54Skin nodule (HP:0200036)2.70737929
55Abnormality of purine metabolism (HP:0004352)2.70142645
56Vascular calcification (HP:0004934)2.69006167
57Optic neuritis (HP:0100653)2.63419314
58Retrobulbar optic neuritis (HP:0100654)2.63419314
59Hypochromic microcytic anemia (HP:0004840)2.63253144
60Metabolic acidosis (HP:0001942)2.60841427
61Purpura (HP:0000979)2.57495532
62Hypomagnesemia (HP:0002917)2.57152865
63Glomerulonephritis (HP:0000099)2.55941868
64Gingival bleeding (HP:0000225)2.55155889
65Mitral stenosis (HP:0001718)2.54591855
66Orchitis (HP:0100796)2.51763420
67Gastrointestinal infarctions (HP:0005244)2.44008636
68Spastic diplegia (HP:0001264)2.42456607
69Lethargy (HP:0001254)2.42039309
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39390882
71Dicarboxylic aciduria (HP:0003215)2.39390882
72Amyloidosis (HP:0011034)2.39343280
73Cardiovascular calcification (HP:0011915)2.38579983
74Abnormal gallbladder morphology (HP:0012437)2.37995053
75Myositis (HP:0100614)2.35973903
76Acanthocytosis (HP:0001927)2.35001721
77Gangrene (HP:0100758)2.32621667
78Esophageal varix (HP:0002040)2.31482437
79Menorrhagia (HP:0000132)2.31101165
80Cholelithiasis (HP:0001081)2.30651846
81Hypoglycemic seizures (HP:0002173)2.29553078
82Irritability (HP:0000737)2.27949414
83Gout (HP:0001997)2.27860172
84Abnormal urine output (HP:0012590)2.26909540
85Recurrent abscess formation (HP:0002722)2.26742287
86Neonatal onset (HP:0003623)2.25965088
87Cholecystitis (HP:0001082)2.21938040
88Abnormal gallbladder physiology (HP:0012438)2.21938040
89Cerebral edema (HP:0002181)2.20581022
90Hydroxyprolinuria (HP:0003080)2.20155718
91Abnormality of proline metabolism (HP:0010907)2.20155718
92Sensorimotor neuropathy (HP:0007141)2.19892775
93Malnutrition (HP:0004395)2.18895205
94Myokymia (HP:0002411)2.13303658
95Pancreatitis (HP:0001733)2.12764189
96Thrombophlebitis (HP:0004418)2.11931779
97Polyuria (HP:0000103)2.11563241
98Increased cerebral lipofuscin (HP:0011813)2.10280247
99Neurofibrillary tangles (HP:0002185)2.07359186
100Hemorrhage of the eye (HP:0011885)2.04853162
101Opisthotonus (HP:0002179)2.03838818
102Vomiting (HP:0002013)2.03563803
103Abnormality of binocular vision (HP:0011514)2.02401461
104Diplopia (HP:0000651)2.02401461
105Enlarged kidneys (HP:0000105)2.01007068
106Dysostosis multiplex (HP:0000943)2.00872656
107Abnormality of iron homeostasis (HP:0011031)2.00720346
108Abnormality of magnesium homeostasis (HP:0004921)2.00555231
109Fair hair (HP:0002286)1.98821261
110Abnormal cartilage morphology (HP:0002763)1.98372980
111Generalized aminoaciduria (HP:0002909)1.97320173
112Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97262099
113Abnormality of polysaccharide metabolism (HP:0011012)1.97262099
114Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97262099
115Abnormality of transition element cation homeostasis (HP:0011030)1.96009975
116Brushfield spots (HP:0001088)1.95583329
117Vacuolated lymphocytes (HP:0001922)1.93718047
118Mucopolysacchariduria (HP:0008155)1.92708518
119Urinary glycosaminoglycan excretion (HP:0003541)1.92708518
120Joint swelling (HP:0001386)1.92294185
121Abnormality of renal excretion (HP:0011036)1.92029035
122Abnormality of the gallbladder (HP:0005264)1.90617188
123Nephritis (HP:0000123)1.90227397
124Late onset (HP:0003584)1.89328353
125Alkalosis (HP:0001948)1.88703731
126Poikilocytosis (HP:0004447)1.87893084
127Recurrent bacterial skin infections (HP:0005406)1.87258149
128Abnormality of the periventricular white matter (HP:0002518)1.85806353
129Anorexia (HP:0002039)1.84142233
130Hyperactive renin-angiotensin system (HP:0000841)1.83874310
131Hypophosphatemic rickets (HP:0004912)1.83533112
132Eczematoid dermatitis (HP:0000976)1.83135125
133Facial shape deformation (HP:0011334)1.83068948
134Potter facies (HP:0002009)1.83068948
135Rickets (HP:0002748)1.82666235
136Hyperaldosteronism (HP:0000859)1.82244207
137Abnormal enzyme/coenzyme activity (HP:0012379)1.81283999
138Hyperphosphaturia (HP:0003109)1.80497933
139Increased neuronal autofluorescent lipopigment (HP:0002074)1.77369153
140Osteomalacia (HP:0002749)1.75767785
141Hyperinsulinemic hypoglycemia (HP:0000825)1.75435002
142Nausea (HP:0002018)1.74579609
143Elevated hepatic transaminases (HP:0002910)1.74226404
144Protuberant abdomen (HP:0001538)1.73408825
145Stomatitis (HP:0010280)1.73350513
146Pulmonary embolism (HP:0002204)1.73248857
147Tetany (HP:0001281)1.72581103
148Reticulocytosis (HP:0001923)1.72420950
149Epistaxis (HP:0000421)1.69851702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.38409129
2ERN14.80876438
3FGFR44.29426187
4SIK14.28885243
5WNK33.13378715
6TAOK32.89217546
7RIPK42.71482886
8OXSR12.68718999
9NTRK32.66071688
10ERBB42.56882273
11MST1R2.47783301
12PKN22.35661667
13INSRR2.34881042
14EPHA42.11636122
15TYK22.06958087
16MAP3K122.02862157
17TRIB31.86902615
18MAP2K41.85330843
19TBK11.82489299
20ABL21.76973367
21FLT31.73409516
22GRK71.70427649
23PIK3CG1.67736044
24MAP3K141.66771430
25PAK61.65496513
26ADRBK21.60717678
27MAPK111.59472369
28NEK91.56369551
29TNK21.48609302
30PTK61.47070965
31CAMKK11.46656296
32LATS11.42447641
33MAP3K31.39210431
34PBK1.37065062
35IRAK31.34130613
36DAPK21.33587264
37FGR1.32880692
38KDR1.28571850
39MAP2K31.28113667
40SGK4941.26840948
41SGK2231.26840948
42JAK11.22803473
43JAK21.22299347
44MATK1.21488283
45NTRK21.20335874
46CAMKK21.16401128
47FES1.14460145
48TXK1.08166363
49UHMK11.06181095
50IKBKE1.02469284
51SYK1.01927631
52MAP3K71.01594293
53FGFR21.01121763
54MAPK40.96846304
55BMX0.96560389
56MAPK130.96115266
57EPHB10.95835442
58MAP3K110.95743115
59CSK0.95171176
60STK38L0.94355769
61STK380.93500775
62GRK60.89951761
63FRK0.89824789
64BLK0.89689982
65PRKAA20.89068976
66MAPK120.87952888
67BMPR20.87435110
68STK110.87232162
69MET0.86537472
70PRKCZ0.85542952
71MAP4K20.84449587
72ERBB20.82834222
73PRPF4B0.80941876
74KSR20.80402493
75PINK10.78345158
76MAP3K20.76474288
77MAP3K130.75301241
78PAK30.74855778
79PDPK10.74049731
80MAP3K100.73743058
81CDK60.73584111
82DAPK10.72085780
83DDR20.70889246
84PRKACG0.70085308
85SGK10.69190594
86TGFBR20.68454109
87EPHA30.66513887
88IRAK40.66124806
89CSF1R0.65892602
90KIT0.64945818
91MARK10.64900465
92GSK3A0.62069060
93DYRK1B0.59226818
94TYRO30.58883726
95TIE10.58773822
96MINK10.58161180
97TAOK20.57883629
98SGK30.56816324
99MAP3K50.55847386
100PRKG10.55430393
101WNK40.54734857
102CDC42BPA0.54723260
103GRK50.54132073
104CDK50.54021770
105LCK0.53811052
106YES10.53717484
107IKBKB0.53522482
108FGFR30.51979798
109IGF1R0.51630295
110ARAF0.51562306
111MAPK70.51540668
112AKT20.51339900
113CAMK2G0.51009528
114CAMK10.50025378
115PRKCQ0.49803416
116CAMK1D0.49415338
117DYRK1A0.49258548
118PRKAA10.48967797
119PRKD30.48717132
120PRKCA0.48209922
121PDK10.46711994
122ZAP700.46119480
123EGFR0.46105715
124MAP4K10.45358642
125PTK20.44191760
126MAP2K60.41318083
127NME20.41177657
128MAP2K10.40414400
129GRK10.40343226
130MAPK150.39883182
131MAP2K20.39533461
132CSNK1G10.36174646
133CHUK0.35403258
134RIPK10.35041785
135STK30.34990275
136SGK20.34841241
137RET0.34558811
138ABL10.32850224
139JAK30.31568665
140MAP3K10.31460004
141PKN10.29952166
142LYN0.29661155
143CDK40.29245274
144PRKCD0.27766399
145FGFR10.25770166
146PRKG20.25394542
147PDK20.24229046
148IRAK20.24076102
149PRKCG0.23741930
150MTOR0.23733224

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.47808672
2Nitrogen metabolism_Homo sapiens_hsa009103.55976685
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.42993289
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.42887945
5Arginine biosynthesis_Homo sapiens_hsa002203.08941367
6Complement and coagulation cascades_Homo sapiens_hsa046102.92764278
7Tryptophan metabolism_Homo sapiens_hsa003802.70975038
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63774995
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52012152
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47692031
11Fatty acid degradation_Homo sapiens_hsa000712.39629856
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36793788
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26988175
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13728228
15Peroxisome_Homo sapiens_hsa041462.04712743
16Staphylococcus aureus infection_Homo sapiens_hsa051502.03085245
17Histidine metabolism_Homo sapiens_hsa003402.02227196
18Butanoate metabolism_Homo sapiens_hsa006502.00310695
19Steroid hormone biosynthesis_Homo sapiens_hsa001402.00286375
20Chemical carcinogenesis_Homo sapiens_hsa052041.99322584
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95069374
22Caffeine metabolism_Homo sapiens_hsa002321.90748931
23PPAR signaling pathway_Homo sapiens_hsa033201.84762630
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79171064
25Propanoate metabolism_Homo sapiens_hsa006401.78819291
26Retinol metabolism_Homo sapiens_hsa008301.72244145
27Fatty acid metabolism_Homo sapiens_hsa012121.70856823
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69504555
29beta-Alanine metabolism_Homo sapiens_hsa004101.66229462
30Selenocompound metabolism_Homo sapiens_hsa004501.59434277
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56842982
32Phenylalanine metabolism_Homo sapiens_hsa003601.55752486
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47031828
34Bile secretion_Homo sapiens_hsa049761.46422341
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46043456
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41454043
37Tyrosine metabolism_Homo sapiens_hsa003501.38534237
38Sulfur metabolism_Homo sapiens_hsa009201.34681890
39Starch and sucrose metabolism_Homo sapiens_hsa005001.32111997
40Steroid biosynthesis_Homo sapiens_hsa001001.27098777
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.23943540
42Pyruvate metabolism_Homo sapiens_hsa006201.23803889
43Fatty acid elongation_Homo sapiens_hsa000621.23239345
44Folate biosynthesis_Homo sapiens_hsa007901.16906422
45Fat digestion and absorption_Homo sapiens_hsa049751.16626857
46ABC transporters_Homo sapiens_hsa020101.15174315
47Biosynthesis of amino acids_Homo sapiens_hsa012301.13804836
48Carbon metabolism_Homo sapiens_hsa012001.06565391
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03423602
50Arginine and proline metabolism_Homo sapiens_hsa003301.01606258
51Sulfur relay system_Homo sapiens_hsa041220.93828601
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92552074
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.91314556
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89135997
55Collecting duct acid secretion_Homo sapiens_hsa049660.86377237
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.85874494
57Vitamin digestion and absorption_Homo sapiens_hsa049770.85377631
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82114185
59Allograft rejection_Homo sapiens_hsa053300.79043589
60Vitamin B6 metabolism_Homo sapiens_hsa007500.78900300
61Lysine degradation_Homo sapiens_hsa003100.73547316
62Other glycan degradation_Homo sapiens_hsa005110.71419631
63One carbon pool by folate_Homo sapiens_hsa006700.69695956
64Glutathione metabolism_Homo sapiens_hsa004800.68670943
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65340256
66Glycerolipid metabolism_Homo sapiens_hsa005610.63060649
67GABAergic synapse_Homo sapiens_hsa047270.60328813
68Pentose phosphate pathway_Homo sapiens_hsa000300.59480180
69Type I diabetes mellitus_Homo sapiens_hsa049400.58760131
70Synaptic vesicle cycle_Homo sapiens_hsa047210.56686492
71Graft-versus-host disease_Homo sapiens_hsa053320.56678245
72Rheumatoid arthritis_Homo sapiens_hsa053230.55913739
73Autoimmune thyroid disease_Homo sapiens_hsa053200.55644282
74Leishmaniasis_Homo sapiens_hsa051400.54247445
75Fatty acid biosynthesis_Homo sapiens_hsa000610.48152430
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46736873
77Mineral absorption_Homo sapiens_hsa049780.44910770
78Metabolic pathways_Homo sapiens_hsa011000.44039280
79Prion diseases_Homo sapiens_hsa050200.42331727
80Morphine addiction_Homo sapiens_hsa050320.36800164
81Osteoclast differentiation_Homo sapiens_hsa043800.36065516
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.34393125
83Tuberculosis_Homo sapiens_hsa051520.34329228
84Asthma_Homo sapiens_hsa053100.33830508
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33249975
86Nicotine addiction_Homo sapiens_hsa050330.32631185
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32572705
88Linoleic acid metabolism_Homo sapiens_hsa005910.31951698
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29132810
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28510717
91Galactose metabolism_Homo sapiens_hsa000520.28476790
92Phagosome_Homo sapiens_hsa041450.26293867
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.24254711
94Serotonergic synapse_Homo sapiens_hsa047260.23996160
95Insulin resistance_Homo sapiens_hsa049310.22205462
96Fructose and mannose metabolism_Homo sapiens_hsa000510.21408481
97Toxoplasmosis_Homo sapiens_hsa051450.19356835
98Glutamatergic synapse_Homo sapiens_hsa047240.15523105
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15040976
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14740165
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.14516472
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14466027
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.13896043
104Insulin secretion_Homo sapiens_hsa049110.13516640
105Antigen processing and presentation_Homo sapiens_hsa046120.13282845
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12053982
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.11958409
108Chemokine signaling pathway_Homo sapiens_hsa040620.11726950
109Glucagon signaling pathway_Homo sapiens_hsa049220.00491199
110Renin-angiotensin system_Homo sapiens_hsa04614-0.1645720
111Insulin signaling pathway_Homo sapiens_hsa04910-0.1580617
112Hepatitis C_Homo sapiens_hsa05160-0.1500962
113Amoebiasis_Homo sapiens_hsa05146-0.1475157
114Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1462336
115Malaria_Homo sapiens_hsa05144-0.1274118
116Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1271362
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1255970
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1246507
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1179643
120Legionellosis_Homo sapiens_hsa05134-0.1067534
121Regulation of autophagy_Homo sapiens_hsa04140-0.1038710
122Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0634616
123Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0617507
124Pertussis_Homo sapiens_hsa05133-0.0599123
125Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0561862
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0529892
127AMPK signaling pathway_Homo sapiens_hsa04152-0.0479599
128Lysosome_Homo sapiens_hsa04142-0.0363351
129African trypanosomiasis_Homo sapiens_hsa05143-0.0130348
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0006760

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