SLC6A13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.45506363
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.45506363
3L-phenylalanine metabolic process (GO:0006558)7.14066597
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.14066597
5aromatic amino acid family catabolic process (GO:0009074)6.80680052
6vitamin A metabolic process (GO:0006776)6.30230137
7indole-containing compound catabolic process (GO:0042436)6.23468166
8indolalkylamine catabolic process (GO:0046218)6.23468166
9tryptophan catabolic process (GO:0006569)6.23468166
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.14456071
11kynurenine metabolic process (GO:0070189)6.06650002
12tryptophan metabolic process (GO:0006568)5.89330821
13glyoxylate metabolic process (GO:0046487)5.84004240
14bile acid biosynthetic process (GO:0006699)5.83721674
15omega-hydroxylase P450 pathway (GO:0097267)5.55770565
16cysteine metabolic process (GO:0006534)5.55110615
17alpha-linolenic acid metabolic process (GO:0036109)5.52963898
18urea metabolic process (GO:0019627)5.46171465
19urea cycle (GO:0000050)5.46171465
20exogenous drug catabolic process (GO:0042738)5.44341483
21negative regulation of fibrinolysis (GO:0051918)5.39894315
22high-density lipoprotein particle remodeling (GO:0034375)5.34134889
23sulfur amino acid catabolic process (GO:0000098)5.31796205
24glial cell proliferation (GO:0014009)5.29440300
25complement activation, alternative pathway (GO:0006957)5.27273733
26regulation of protein activation cascade (GO:2000257)5.23027668
27regulation of fibrinolysis (GO:0051917)5.17856834
28peptidyl-glutamic acid carboxylation (GO:0017187)5.17174612
29protein carboxylation (GO:0018214)5.17174612
30serine family amino acid catabolic process (GO:0009071)5.09941327
31nitrogen cycle metabolic process (GO:0071941)5.02509128
32response to mercury ion (GO:0046689)5.01350531
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.01156525
34bile acid metabolic process (GO:0008206)4.97107604
35aromatic amino acid family metabolic process (GO:0009072)4.96706302
36regulation of complement activation (GO:0030449)4.90281176
37lysine metabolic process (GO:0006553)4.88128300
38lysine catabolic process (GO:0006554)4.88128300
39homocysteine metabolic process (GO:0050667)4.78853413
40regulation of cholesterol esterification (GO:0010872)4.75680388
41tyrosine metabolic process (GO:0006570)4.74094205
42regulation of triglyceride catabolic process (GO:0010896)4.73288261
43reverse cholesterol transport (GO:0043691)4.68276424
44amino-acid betaine metabolic process (GO:0006577)4.66273998
45protein-lipid complex remodeling (GO:0034368)4.63905561
46macromolecular complex remodeling (GO:0034367)4.63905561
47plasma lipoprotein particle remodeling (GO:0034369)4.63905561
48alpha-amino acid catabolic process (GO:1901606)4.62560301
49triglyceride homeostasis (GO:0070328)4.48146104
50acylglycerol homeostasis (GO:0055090)4.48146104
51negative regulation of sterol transport (GO:0032372)4.45327599
52negative regulation of cholesterol transport (GO:0032375)4.45327599
53phospholipid efflux (GO:0033700)4.42748901
54indolalkylamine metabolic process (GO:0006586)4.42381486
55cellular ketone body metabolic process (GO:0046950)4.42354315
56glutamate metabolic process (GO:0006536)4.34012392
57drug metabolic process (GO:0017144)4.33846411
58plasma lipoprotein particle clearance (GO:0034381)4.31524872
59amine catabolic process (GO:0009310)4.30441974
60cellular biogenic amine catabolic process (GO:0042402)4.30441974
61cellular amino acid catabolic process (GO:0009063)4.28236249
62glycine metabolic process (GO:0006544)4.26810259
63* gamma-aminobutyric acid transport (GO:0015812)4.23554810
64histone H3-K9 demethylation (GO:0033169)4.22056660
65bile acid and bile salt transport (GO:0015721)4.21188117
66serine family amino acid metabolic process (GO:0009069)4.20946151
67coenzyme catabolic process (GO:0009109)4.19124264
68cellular modified amino acid catabolic process (GO:0042219)4.16256000
69benzene-containing compound metabolic process (GO:0042537)4.13867886
70imidazole-containing compound metabolic process (GO:0052803)4.13157815
71ethanol oxidation (GO:0006069)4.09991566
72metanephric nephron tubule development (GO:0072234)4.07308020
73metanephric tubule development (GO:0072170)4.07308020
74cellular glucuronidation (GO:0052695)4.05288245
75serine family amino acid biosynthetic process (GO:0009070)4.03598133
76cholesterol efflux (GO:0033344)4.02108139
77drug catabolic process (GO:0042737)3.98098696
78dicarboxylic acid biosynthetic process (GO:0043650)3.96509612
79low-density lipoprotein particle remodeling (GO:0034374)3.95290373
80plasma lipoprotein particle assembly (GO:0034377)3.93282171
81oxidative demethylation (GO:0070989)3.93159717
82aldehyde catabolic process (GO:0046185)3.93005864
83short-chain fatty acid metabolic process (GO:0046459)3.90917225
84fibrinolysis (GO:0042730)3.89968496
85metanephric nephron epithelium development (GO:0072243)3.89709781
86urate metabolic process (GO:0046415)3.89631846
87arginine metabolic process (GO:0006525)3.88525360
88protein-chromophore linkage (GO:0018298)3.85604675
89ketone body metabolic process (GO:1902224)3.82572274
90organic acid catabolic process (GO:0016054)3.77967306
91carboxylic acid catabolic process (GO:0046395)3.77967306
92sodium-independent organic anion transport (GO:0043252)3.77530904
93acetyl-CoA metabolic process (GO:0006084)3.76282536
94epoxygenase P450 pathway (GO:0019373)3.73747995
95metanephric epithelium development (GO:0072207)3.72227861
96positive regulation of lipid catabolic process (GO:0050996)3.71589322
97phospholipid homeostasis (GO:0055091)3.71039826
98blood coagulation, intrinsic pathway (GO:0007597)3.70482428
99drug transmembrane transport (GO:0006855)3.70355126
100positive regulation of lipoprotein lipase activity (GO:0051006)3.68373238
101positive regulation of triglyceride lipase activity (GO:0061365)3.68373238
102S-adenosylmethionine metabolic process (GO:0046500)3.67220612
103cholesterol homeostasis (GO:0042632)3.66013984
104cytolysis (GO:0019835)3.65612855
105cofactor catabolic process (GO:0051187)3.63858901
106very-low-density lipoprotein particle assembly (GO:0034379)3.63782516
107mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.63287977
108glucuronate metabolic process (GO:0019585)3.62318608
109uronic acid metabolic process (GO:0006063)3.62318608
110sterol homeostasis (GO:0055092)3.60556685
1112-oxoglutarate metabolic process (GO:0006103)3.60121129
112complement activation (GO:0006956)3.59087644
113regulation of cholesterol homeostasis (GO:2000188)3.57872712
114complement activation, classical pathway (GO:0006958)3.57674368
115protein activation cascade (GO:0072376)3.57482257
116negative regulation of lipase activity (GO:0060192)3.56639609
117aspartate family amino acid catabolic process (GO:0009068)3.55620096
118neurotransmitter catabolic process (GO:0042135)3.55608942
119regulation of plasminogen activation (GO:0010755)3.53238244
120opsonization (GO:0008228)3.48144248
121cell volume homeostasis (GO:0006884)3.43042301
122organic cation transport (GO:0015695)3.42985998
123regulation of apoptotic cell clearance (GO:2000425)3.37325462
124phosphate ion transport (GO:0006817)3.36330149
125peripheral nervous system axon ensheathment (GO:0032292)3.34236248
126myelination in peripheral nervous system (GO:0022011)3.34236248
127ethanol metabolic process (GO:0006067)3.34235728
128negative regulation of metanephros development (GO:0072217)3.32988407
129quaternary ammonium group transport (GO:0015697)3.32282271
130negative regulation of protein activation cascade (GO:2000258)3.30291860
131regulation of humoral immune response (GO:0002920)3.06460214
132drug transport (GO:0015893)3.01442448
133positive regulation of p38MAPK cascade (GO:1900745)2.96956180
134fat-soluble vitamin metabolic process (GO:0006775)2.96892534
135phenylpropanoid metabolic process (GO:0009698)2.95207292
136positive regulation of cellular amine metabolic process (GO:0033240)2.94808895
137cellular hyperosmotic response (GO:0071474)2.93365357
138negative regulation of complement activation (GO:0045916)2.92792951
139carnitine metabolic process (GO:0009437)2.92511407
140phosphate ion transmembrane transport (GO:0035435)2.91634557
141detection of light stimulus involved in sensory perception (GO:0050962)2.89764002
142detection of light stimulus involved in visual perception (GO:0050908)2.89764002
143xenobiotic catabolic process (GO:0042178)2.89231127
144regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.86014232
145retinal metabolic process (GO:0042574)2.83451519
146regulation of p38MAPK cascade (GO:1900744)2.83266219
147regulation of apoptotic process involved in morphogenesis (GO:1902337)2.81069788
148nephron tubule development (GO:0072080)2.74927537
149flavonoid metabolic process (GO:0009812)2.74481610
150xenobiotic metabolic process (GO:0006805)2.73260206
151disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.71347413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.31335481
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13128961
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.77684622
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.42532762
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.16117392
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.15148213
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.97868201
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.93413339
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93380415
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.97082356
11DROSHA_22980978_ChIP-Seq_HELA_Human2.33659236
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30440987
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16106460
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.11476386
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00844147
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8121855
17GBX2_23144817_ChIP-Seq_PC3_Human1.97344453
18CLOCK_20551151_ChIP-Seq_293T_Human1.69062694
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63224479
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61907155
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.61145197
22GATA1_22025678_ChIP-Seq_K562_Human1.60940693
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.60474500
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50298021
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50298021
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44251893
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43493099
28* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42142352
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.39696666
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38781580
31HTT_18923047_ChIP-ChIP_STHdh_Human1.38631186
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38088387
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36120245
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.35936636
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35466516
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35258665
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25628385
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24686462
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22727585
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22186951
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20335600
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16950010
43* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15746999
44ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11827618
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11583842
46IGF1R_20145208_ChIP-Seq_DFB_Human1.10940111
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10202995
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.07410721
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06865558
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04305724
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03987061
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03252231
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.01639532
54CTCF_27219007_Chip-Seq_Bcells_Human1.00976941
55RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99081037
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98750450
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98619248
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95749538
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94230178
60STAT3_23295773_ChIP-Seq_U87_Human0.94138296
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93045724
62REST_21632747_ChIP-Seq_MESCs_Mouse0.92297882
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91786957
64AHR_22903824_ChIP-Seq_MCF-7_Human0.91005205
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90522363
66SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89845722
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89532689
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89484258
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89406412
70SMAD4_21741376_ChIP-Seq_HESCs_Human0.88379891
71GF1_26923725_Chip-Seq_HPCs_Mouse0.86660803
72GATA4_25053715_ChIP-Seq_YYC3_Human0.86565473
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85482677
74RARB_27405468_Chip-Seq_BRAIN_Mouse0.85229501
75TCF4_23295773_ChIP-Seq_U87_Human0.85172071
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83425022
77SMAD4_21799915_ChIP-Seq_A2780_Human0.83289940
78AR_19668381_ChIP-Seq_PC3_Human0.83145067
79* SMC4_20622854_ChIP-Seq_HELA_Human0.83111097
80P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82641844
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82007839
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81953103
83PHF8_20622853_ChIP-Seq_HELA_Human0.81743817
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81538638
85EP300_21415370_ChIP-Seq_HL-1_Mouse0.81045894
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80984185
87HNFA_21074721_ChIP-Seq_CACO-2_Human0.80934930
88TBL1_22424771_ChIP-Seq_293T_Human0.80614382
89OCT4_19829295_ChIP-Seq_ESCs_Human0.80470389
90KLF4_19829295_ChIP-Seq_ESCs_Human0.80364913
91RING1B_27294783_Chip-Seq_ESCs_Mouse0.80208067
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80021678
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79668536
94ZNF263_19887448_ChIP-Seq_K562_Human0.79615258
95ESR2_21235772_ChIP-Seq_MCF-7_Human0.79260957
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79188577
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78622866
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78039602
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77768046
100ETV1_20927104_ChIP-Seq_GIST48_Human0.77300657
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77270945
102CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76879926
103SMAD4_21741376_ChIP-Seq_EPCs_Human0.76138831
104REST_18959480_ChIP-ChIP_MESCs_Mouse0.75573442
105NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75411730
106NFYA_21822215_ChIP-Seq_K562_Human0.75237000
107* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.74469886
108AR_21572438_ChIP-Seq_LNCaP_Human0.74467609
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.74261835
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73840823
111* SOX2_21211035_ChIP-Seq_LN229_Gbm0.73627728
112PIAS1_25552417_ChIP-Seq_VCAP_Human0.73516482
113SMC3_22415368_ChIP-Seq_MEFs_Mouse0.73493914
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72819861
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71715488
116RARA_24833708_ChIP-Seq_LIVER_Mouse0.71656501
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67546351
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65658502
119LXR_22292898_ChIP-Seq_THP-1_Human0.65432379
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65375454
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64931947
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64194643
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64194643
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.60116503
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60107962
126* RARB_24833708_ChIP-Seq_LIVER_Mouse0.59698247
127EGR1_19032775_ChIP-ChIP_M12_Human0.59270206
128GATA1_19941826_ChIP-Seq_K562_Human0.58789310
129CEBPB_22108803_ChIP-Seq_LS180_Human0.56912278
130AR_20517297_ChIP-Seq_VCAP_Human0.56129410
131MYC_19915707_ChIP-ChIP_AK7_Human0.55959845
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55188844
133GATA2_19941826_ChIP-Seq_K562_Human0.54661325
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.54080652
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54047670
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.52065875
137ESET_19884257_ChIP-Seq_ESCs_Mouse0.51208107
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.51104738
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.50832676
140PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49512615
141STAT1_17558387_ChIP-Seq_HELA_Human0.48708840
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.47481700
143P53_21459846_ChIP-Seq_SAOS-2_Human0.46788537
144* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46453779
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.46299862
146* CBP_21632823_ChIP-Seq_H3396_Human0.45097856
147TAF2_19829295_ChIP-Seq_ESCs_Human0.44711163
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43829982
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.43587959
150PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.41898183
151E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.41738411
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.41061421
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41012748
154GATA6_25053715_ChIP-Seq_YYC3_Human0.40182145
155EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.38360435
156SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37468018
157* MYC_27129775_Chip-Seq_CORNEA_Mouse0.36133899
158CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36007505
159ERG_21242973_ChIP-ChIP_JURKAT_Human0.35668988
160TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.35361177
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.35105587
162SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.34996476
163* FOXH1_21741376_ChIP-Seq_EPCs_Human0.34833004
164SOX2_20726797_ChIP-Seq_SW620_Human0.34011425
165FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.33588527
166RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.33362568
167GATA3_24758297_ChIP-Seq_MCF-7_Human0.32907439
168SPI1_26923725_Chip-Seq_HPCs_Mouse0.32734712
169GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.32619324
170BCAT_22108803_ChIP-Seq_LS180_Human0.32379212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.18034161
2MP0005360_urolithiasis7.67872482
3MP0005085_abnormal_gallbladder_physiolo6.16807782
4MP0005365_abnormal_bile_salt6.03089975
5MP0008875_abnormal_xenobiotic_pharmacok4.99397401
6MP0003879_abnormal_hair_cell4.64823346
7MP0003806_abnormal_nucleotide_metabolis4.14332305
8MP0003252_abnormal_bile_duct3.76064781
9MP0010329_abnormal_lipoprotein_level3.56632941
10MP0003195_calcinosis3.36283261
11MP0009840_abnormal_foam_cell3.20861727
12MP0005377_hearing/vestibular/ear_phenot3.10479084
13MP0003878_abnormal_ear_physiology3.10479084
14MP0005332_abnormal_amino_acid2.98787391
15MP0005083_abnormal_biliary_tract2.80569633
16MP0001666_abnormal_nutrient_absorption2.48923762
17MP0005423_abnormal_somatic_nervous2.47670331
18MP0001986_abnormal_taste_sensitivity2.46245222
19MP0003191_abnormal_cellular_cholesterol2.37613798
20MP0004019_abnormal_vitamin_homeostasis2.33326030
21MP0000609_abnormal_liver_physiology2.13039976
22MP0002118_abnormal_lipid_homeostasis2.10539093
23MP0001501_abnormal_sleep_pattern2.09343422
24MP0002735_abnormal_chemical_nociception2.02923002
25MP0002138_abnormal_hepatobiliary_system2.00287078
26MP0002653_abnormal_ependyma_morphology1.85451556
27MP0005319_abnormal_enzyme/_coenzyme1.83307500
28MP0003868_abnormal_feces_composition1.75088433
29MP0001764_abnormal_homeostasis1.72871468
30MP0005551_abnormal_eye_electrophysiolog1.71949022
31MP0005584_abnormal_enzyme/coenzyme_acti1.63606531
32MP0003183_abnormal_peptide_metabolism1.56068460
33MP0001324_abnormal_eye_pigmentation1.50601776
34MP0009697_abnormal_copulation1.46533267
35MP0009643_abnormal_urine_homeostasis1.46492665
36MP0001485_abnormal_pinna_reflex1.43519841
37MP0003011_delayed_dark_adaptation1.37540672
38MP0003186_abnormal_redox_activity1.36383115
39MP0005451_abnormal_body_composition1.32519037
40MP0005253_abnormal_eye_physiology1.29895141
41MP0003656_abnormal_erythrocyte_physiolo1.26700684
42MP0004859_abnormal_synaptic_plasticity1.20205629
43MP0000598_abnormal_liver_morphology1.18264618
44MP0002272_abnormal_nervous_system1.17573545
45MP0001879_abnormal_lymphatic_vessel1.16251479
46MP0000920_abnormal_myelination1.10919049
47MP0005636_abnormal_mineral_homeostasis1.09745429
48MP0000604_amyloidosis1.07931591
49MP0005647_abnormal_sex_gland1.07297143
50MP0009764_decreased_sensitivity_to1.06980500
51MP0005670_abnormal_white_adipose1.06525658
52MP0002229_neurodegeneration1.05836853
53MP0003705_abnormal_hypodermis_morpholog1.05392985
54MP0001486_abnormal_startle_reflex1.05073903
55MP0009763_increased_sensitivity_to1.03839712
56MP0003959_abnormal_lean_body0.95809533
57MP0008469_abnormal_protein_level0.93594033
58MP0002254_reproductive_system_inflammat0.92270655
59MP0005187_abnormal_penis_morphology0.92173778
60MP0010386_abnormal_urinary_bladder0.91534246
61MP0009642_abnormal_blood_homeostasis0.89835181
62MP0002090_abnormal_vision0.89643159
63MP0009745_abnormal_behavioral_response0.86737970
64MP0002249_abnormal_larynx_morphology0.84695448
65MP0006036_abnormal_mitochondrial_physio0.84578709
66MP0002876_abnormal_thyroid_physiology0.84410048
67MP0003633_abnormal_nervous_system0.83972738
68MP0003631_nervous_system_phenotype0.82734983
69MP0003690_abnormal_glial_cell0.81225828
70MP0004130_abnormal_muscle_cell0.81169911
71MP0003634_abnormal_glial_cell0.80956496
72MP0005376_homeostasis/metabolism_phenot0.80557555
73MP0009765_abnormal_xenobiotic_induced0.78754528
74MP0010368_abnormal_lymphatic_system0.78454828
75MP0005408_hypopigmentation0.78412801
76MP0002557_abnormal_social/conspecific_i0.77462399
77MP0001756_abnormal_urination0.76763809
78MP0002078_abnormal_glucose_homeostasis0.75270198
79MP0005535_abnormal_body_temperature0.74962049
80MP0001440_abnormal_grooming_behavior0.74706126
81MP0002971_abnormal_brown_adipose0.74373790
82MP0005084_abnormal_gallbladder_morpholo0.73939415
83MP0001661_extended_life_span0.72509405
84MP0003632_abnormal_nervous_system0.72119589
85MP0005464_abnormal_platelet_physiology0.71966338
86MP0008569_lethality_at_weaning0.70181047
87MP0005334_abnormal_fat_pad0.68800872
88MP0002063_abnormal_learning/memory/cond0.68437015
89MP0002638_abnormal_pupillary_reflex0.67687614
90MP0005391_vision/eye_phenotype0.66749898
91MP0002136_abnormal_kidney_physiology0.66369359
92MP0001963_abnormal_hearing_physiology0.65435333
93MP0002572_abnormal_emotion/affect_behav0.65025408
94MP0002736_abnormal_nociception_after0.64622706
95MP0005220_abnormal_exocrine_pancreas0.64569207
96MP0000013_abnormal_adipose_tissue0.62849174
97MP0001348_abnormal_lacrimal_gland0.62818767
98MP0005623_abnormal_meninges_morphology0.62751495
99MP0005195_abnormal_posterior_eye0.62665816
100MP0000747_muscle_weakness0.62615018
101MP0003329_amyloid_beta_deposits0.62505090
102MP0004233_abnormal_muscle_weight0.60546136
103MP0005266_abnormal_metabolism0.60441536
104MP0002067_abnormal_sensory_capabilities0.59773331
105MP0002064_seizures0.59710816
106MP0003724_increased_susceptibility_to0.59554303
107MP0000639_abnormal_adrenal_gland0.59510614
108MP0002332_abnormal_exercise_endurance0.59131925
109MP0005257_abnormal_intraocular_pressure0.57557240
110MP0002282_abnormal_trachea_morphology0.57352362
111MP0000026_abnormal_inner_ear0.57004162
112MP0001968_abnormal_touch/_nociception0.56936140
113MP0001970_abnormal_pain_threshold0.56405862
114MP0002132_abnormal_respiratory_system0.55306508
115MP0006035_abnormal_mitochondrial_morpho0.54844413
116MP0004742_abnormal_vestibular_system0.53510083
117MP0009046_muscle_twitch0.53494631
118MP0009053_abnormal_anal_canal0.51199412
119MP0005395_other_phenotype0.50780278
120MP0005666_abnormal_adipose_tissue0.50427134
121MP0005058_abnormal_lysosome_morphology0.49529884
122MP0005448_abnormal_energy_balance0.48180339
123MP0008873_increased_physiological_sensi0.46819920
124MP0003638_abnormal_response/metabolism_0.46134119
125MP0003436_decreased_susceptibility_to0.45454957
126MP0008874_decreased_physiological_sensi0.44924878
127MP0002928_abnormal_bile_duct0.44870167
128MP0002168_other_aberrant_phenotype0.43803036
129MP0003075_altered_response_to0.42396534
130MP0001853_heart_inflammation0.41041717
131MP0003953_abnormal_hormone_level0.40815502
132MP0005167_abnormal_blood-brain_barrier0.40241639
133MP0004043_abnormal_pH_regulation0.39608878
134MP0004782_abnormal_surfactant_physiolog0.38761696
135MP0001765_abnormal_ion_homeostasis0.37538321
136MP0004381_abnormal_hair_follicle0.36603694
137MP0001845_abnormal_inflammatory_respons0.36563738
138MP0005166_decreased_susceptibility_to0.36315151
139MP0000230_abnormal_systemic_arterial0.36136843
140MP0009115_abnormal_fat_cell0.36030559
141MP0006082_CNS_inflammation0.35610986
142MP0008872_abnormal_physiological_respon0.35237913
143MP0002837_dystrophic_cardiac_calcinosis0.34697300
144MP0000249_abnormal_blood_vessel0.34469495
145MP0003718_maternal_effect0.33977250
146MP0002135_abnormal_kidney_morphology0.33919634
147MP0004264_abnormal_extraembryonic_tissu0.33373789
148MP0002970_abnormal_white_adipose0.33165790
149MP0002796_impaired_skin_barrier0.32632352
150MP0004883_abnormal_blood_vessel0.32574726
151MP0002822_catalepsy0.32403434
152MP0009672_abnormal_birth_weight0.31953993
153MP0005164_abnormal_response_to0.30832629
154MP0000579_abnormal_nail_morphology0.30616843
155MP0001243_abnormal_dermal_layer0.28331311

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.14134825
2Deep venous thrombosis (HP:0002625)7.10366463
3Intrahepatic cholestasis (HP:0001406)7.05638252
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.37124247
5Prolonged partial thromboplastin time (HP:0003645)6.21637076
6Xanthomatosis (HP:0000991)6.19579748
7Hypobetalipoproteinemia (HP:0003563)5.96667399
8Hyperlipoproteinemia (HP:0010980)5.49022845
9Nuclear cataract (HP:0100018)5.32250222
10Complement deficiency (HP:0004431)5.22430124
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.93101876
12Increased circulating renin level (HP:0000848)4.89241496
13Joint hemorrhage (HP:0005261)4.72856739
14Hyperammonemia (HP:0001987)4.65848980
15Hypolipoproteinemia (HP:0010981)4.57555611
16Hyperglycinemia (HP:0002154)4.50936308
17Facial shape deformation (HP:0011334)4.47244601
18Potter facies (HP:0002009)4.47244601
19Ketosis (HP:0001946)4.35566834
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33499160
21Hyperglycinuria (HP:0003108)4.31753896
22Epidermoid cyst (HP:0200040)4.27522507
23Abnormality of the common coagulation pathway (HP:0010990)4.26169597
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.22371195
25Abnormality of sulfur amino acid metabolism (HP:0004339)4.22036495
26Metabolic alkalosis (HP:0200114)4.20383397
27Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18340829
28Abnormality of glycine metabolism (HP:0010895)4.17842453
29Abnormality of serine family amino acid metabolism (HP:0010894)4.17842453
30Abnormality of methionine metabolism (HP:0010901)4.12157008
31Hypoalphalipoproteinemia (HP:0003233)4.10343046
32Hypomagnesemia (HP:0002917)4.09192741
33Decreased electroretinogram (ERG) amplitude (HP:0000654)4.03335544
34Fat malabsorption (HP:0002630)3.97401221
35Hypokalemic alkalosis (HP:0001949)3.93265704
36Hypoglycemic coma (HP:0001325)3.79658807
37Abnormality of complement system (HP:0005339)3.77508892
38Polyuria (HP:0000103)3.72181376
39Abnormality of pyrimidine metabolism (HP:0004353)3.64342712
40Abnormal urine output (HP:0012590)3.59782910
41Abnormality of the intrinsic pathway (HP:0010989)3.54826251
42Abnormality of fatty-acid metabolism (HP:0004359)3.50575500
43Hypercholesterolemia (HP:0003124)3.49842802
44Conjugated hyperbilirubinemia (HP:0002908)3.44759020
45Hyperactive renin-angiotensin system (HP:0000841)3.36331885
46Abnormality of magnesium homeostasis (HP:0004921)3.36200788
47Polydipsia (HP:0001959)3.34038638
48Abnormal drinking behavior (HP:0030082)3.34038638
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33211736
50Hyperbilirubinemia (HP:0002904)3.30274907
51Delayed CNS myelination (HP:0002188)3.26785706
52Ketoacidosis (HP:0001993)3.19492756
53Abnormality of renal excretion (HP:0011036)3.17466699
54Abnormality of nucleobase metabolism (HP:0010932)3.16521553
55Tubular atrophy (HP:0000092)3.14092984
56Abnormality of serum amino acid levels (HP:0003112)3.10219963
57Myocardial infarction (HP:0001658)3.10066587
58Abnormality of chloride homeostasis (HP:0011422)3.08593819
59Hepatocellular carcinoma (HP:0001402)3.03356085
60Steatorrhea (HP:0002570)3.00208024
61Segmental peripheral demyelination/remyelination (HP:0003481)2.99138158
62Abnormality of purine metabolism (HP:0004352)2.92610973
63Chronic hepatic failure (HP:0100626)2.91348319
64Focal segmental glomerulosclerosis (HP:0000097)2.90792189
65Gout (HP:0001997)2.89722702
66Abnormal ciliary motility (HP:0012262)2.88995876
67Decreased central vision (HP:0007663)2.88973341
68Macular degeneration (HP:0000608)2.88566782
69Abnormality of macular pigmentation (HP:0008002)2.86042747
70Metabolic acidosis (HP:0001942)2.85774381
71Abnormal respiratory motile cilium physiology (HP:0012261)2.85235656
72Vascular calcification (HP:0004934)2.82178352
73Spontaneous abortion (HP:0005268)2.80878660
74Choroideremia (HP:0001139)2.77416134
75Hyperaldosteronism (HP:0000859)2.75621838
76Congenital stationary night blindness (HP:0007642)2.73728240
77Action tremor (HP:0002345)2.70942419
78Myokymia (HP:0002411)2.70760709
79Systemic lupus erythematosus (HP:0002725)2.70677546
80Hypochromic microcytic anemia (HP:0004840)2.69215019
81Scotoma (HP:0000575)2.68937273
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68807580
83Dicarboxylic aciduria (HP:0003215)2.68807580
84Ulnar claw (HP:0001178)2.66820924
85Skin nodule (HP:0200036)2.64017538
86Lethargy (HP:0001254)2.63640056
87Osteomalacia (HP:0002749)2.61192052
88Attenuation of retinal blood vessels (HP:0007843)2.59942936
89Renal salt wasting (HP:0000127)2.58175666
90Rhinitis (HP:0012384)2.56616462
91Zonular cataract (HP:0010920)2.54724806
92Cardiovascular calcification (HP:0011915)2.50078116
93Acanthocytosis (HP:0001927)2.46224715
94Glomerulonephritis (HP:0000099)2.44816332
95Spastic diplegia (HP:0001264)2.42796510
96Bony spicule pigmentary retinopathy (HP:0007737)2.41807733
97Occipital encephalocele (HP:0002085)2.40813403
98Neonatal onset (HP:0003623)2.37760282
99Mitral stenosis (HP:0001718)2.37067514
100Metaphyseal dysplasia (HP:0100255)2.36477851
101Glomerulosclerosis (HP:0000096)2.35766229
102Irritability (HP:0000737)2.33625980
103Hypoglycemic seizures (HP:0002173)2.33381136
104Recurrent gram-negative bacterial infections (HP:0005420)2.33210490
105Polar cataract (HP:0010696)2.32030398
106Abnormal gallbladder morphology (HP:0012437)2.30053603
107Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27899843
108Cerebral edema (HP:0002181)2.27678328
109Malnutrition (HP:0004395)2.26094046
110Generalized aminoaciduria (HP:0002909)2.26086841
111Sensorimotor neuropathy (HP:0007141)2.25677658
112Cholelithiasis (HP:0001081)2.25477744
113Enlarged kidneys (HP:0000105)2.21810985
114Pancreatitis (HP:0001733)2.19441276
115Abnormal biliary tract physiology (HP:0012439)2.18283588
116Bile duct proliferation (HP:0001408)2.18283588
117Amyloidosis (HP:0011034)2.18261856
118Alkalosis (HP:0001948)2.17205140
119Gingival bleeding (HP:0000225)2.16970697
120Menorrhagia (HP:0000132)2.16701708
121Vomiting (HP:0002013)2.15702508
122Esophageal varix (HP:0002040)2.15070924
123Abnormal gallbladder physiology (HP:0012438)2.15031123
124Cholecystitis (HP:0001082)2.15031123
125Late onset (HP:0003584)2.13553860
126Rickets (HP:0002748)2.13457420
127Hypophosphatemic rickets (HP:0004912)2.10719762
128Hyperphosphaturia (HP:0003109)2.10562530
129Dynein arm defect of respiratory motile cilia (HP:0012255)2.09052372
130Absent/shortened dynein arms (HP:0200106)2.09052372
131Abnormality of the fingertips (HP:0001211)2.08304233
132Nephritis (HP:0000123)2.07571366
133Hemorrhage of the eye (HP:0011885)2.06889675
134Abnormality of iron homeostasis (HP:0011031)2.05973772
135Thrombophlebitis (HP:0004418)2.05560017
136Proximal tubulopathy (HP:0000114)2.04444548
137Brushfield spots (HP:0001088)2.04417035
138Abnormality of renin-angiotensin system (HP:0000847)2.03862032
139Increased purine levels (HP:0004368)2.03807193
140Hyperuricemia (HP:0002149)2.03807193
141Chorioretinal atrophy (HP:0000533)2.02047580
142Nasal polyposis (HP:0100582)2.01175907
143Abnormality of transition element cation homeostasis (HP:0011030)2.01164682
144Termporal pattern (HP:0011008)1.99557509
145Insidious onset (HP:0003587)1.99557509
146Abnormality of proline metabolism (HP:0010907)1.98369638
147Hydroxyprolinuria (HP:0003080)1.98369638
148Recurrent sinusitis (HP:0011108)1.98027243
149Opisthotonus (HP:0002179)1.97457714
150Hypokalemia (HP:0002900)1.97200239
151Bilateral sensorineural hearing impairment (HP:0008619)1.96743666
152Tubulointerstitial fibrosis (HP:0005576)1.94123663
153Abnormality of the nasal mucosa (HP:0000433)1.93998874
154Abnormal cartilage morphology (HP:0002763)1.93584045
155Poikilocytosis (HP:0004447)1.92925104
156Abnormality of the gallbladder (HP:0005264)1.89885860
157Abnormality of urine glucose concentration (HP:0011016)1.89811009
158Glycosuria (HP:0003076)1.89811009
159Portal hypertension (HP:0001409)1.85648054
160Stage 5 chronic kidney disease (HP:0003774)1.85449899
161Elevated hepatic transaminases (HP:0002910)1.84355017
162Genetic anticipation (HP:0003743)1.84237842
163Peripheral hypomyelination (HP:0007182)1.84234766
164Abnormal enzyme/coenzyme activity (HP:0012379)1.84161008
165Confusion (HP:0001289)1.82483826
166Hyperinsulinemic hypoglycemia (HP:0000825)1.81781883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.26865074
2FGFR44.51728486
3SIK14.50165810
4ERN13.95417035
5NTRK33.36090560
6TAOK32.97890296
7CDK122.88502108
8STK382.77160428
9INSRR2.60810167
10ERBB42.55768348
11EPHA42.30006024
12BRD42.18948956
13PDK22.12575738
14PKN22.08237938
15TRIB32.07609907
16MST1R2.05470794
17MAP2K41.99770726
18MAPK111.87688249
19TYK21.86452805
20FLT31.72553077
21PIK3CG1.61125852
22CAMK1G1.60127439
23CAMK1D1.58246612
24PTK61.47274327
25PRKAA21.46407736
26KDR1.40270062
27ABL21.39617454
28DAPK21.39559382
29PTK2B1.36264686
30GRK61.32643790
31NTRK21.29972135
32JAK21.29022868
33MAP3K71.28033692
34PRKD31.27510478
35FER1.26720065
36NEK91.26232647
37STK391.25673137
38FGFR21.20547988
39MAP2K31.07926589
40TBK11.07432979
41MARK11.05943566
42MAPK41.03026753
43NEK61.02191113
44PINK11.01857240
45JAK11.00758515
46DYRK1A1.00147630
47FRK0.98412925
48MAP3K140.97840799
49LATS10.96557533
50EPHB10.91779998
51ERBB20.91195015
52MAP3K100.89304789
53PRKCZ0.87478626
54MAPK120.87360494
55SGK10.85849581
56CSK0.84077364
57PRKACG0.82866596
58SGK30.82599489
59TIE10.82435621
60WNK30.79888524
61CASK0.78170995
62FGR0.77332583
63CAMKK10.74586784
64PHKG20.74146928
65PHKG10.74146928
66PRKAA10.73906996
67DYRK1B0.73797302
68MAP3K130.73089018
69TGFBR20.72721716
70GSK3A0.72602600
71CDK60.72442477
72MET0.72212487
73MAP3K30.70808164
74CDK50.69018948
75CAMK2G0.68833020
76MAPKAPK30.68042823
77MAP4K10.66690757
78MAP2K60.66432968
79ARAF0.65282357
80LATS20.63784494
81MAPK150.63422430
82ITK0.63149588
83IKBKE0.63090897
84STK38L0.62720656
85CSF1R0.62624416
86NTRK10.62614921
87FGFR30.62418725
88MAP3K110.62306115
89SGK20.61342324
90EPHA30.58233086
91PAK60.57915434
92CDK90.57348556
93IRAK30.57263409
94PRKCQ0.56870439
95PTK20.55185942
96SGK2230.54636742
97SGK4940.54636742
98MAPK70.54065683
99PRKACA0.53644735
100PDPK10.52346956
101RIPK10.52232366
102CAMK40.49769481
103IGF1R0.47550957
104PLK20.47343897
105CSNK1G10.46956362
106CDK40.46000351
107MAPK100.45617775
108KSR20.42735506
109FES0.41474826
110MAP3K90.41473940
111RPS6KA20.40763414
112PRKCG0.40279480
113RPS6KA30.40278700
114WNK40.40088242
115MARK20.38457981
116OXSR10.38441357
117PDK10.38321425
118TYRO30.37094126
119PKN10.36768059
120AKT20.35253187
121GRK50.35207650
122GRK10.33574614
123MAP2K10.33431264
124MTOR0.33219017
125SIK20.33172500
126PIK3CA0.32598178
127RET0.32262549
128JAK30.32085519
129ADRBK10.31822748
130MAPK130.31821246
131MAP3K60.31689417
132DDR20.31213867
133MELK0.31093824
134TAOK20.31053754
135ROCK10.31005892
136EGFR0.30863326
137EPHB20.30642946
138MAP3K50.30020457
139MAP2K20.29962003
140PRKCA0.29879226
141MUSK0.29629104
142UHMK10.29000536
143BLK0.28625421
144CAMK2A0.28007351
145PRKD10.27834547
146LRRK20.26981554
147SRC0.26556970
148BTK0.26010146
149PDK40.25662588
150PDK30.25662588
151PRKCH0.25653403
152MAPK30.25357263
153BMX0.24550953

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39863716
2Nitrogen metabolism_Homo sapiens_hsa009103.84447110
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32849222
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23003592
5Arginine biosynthesis_Homo sapiens_hsa002203.02714995
6Tryptophan metabolism_Homo sapiens_hsa003802.72464217
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71092584
8Complement and coagulation cascades_Homo sapiens_hsa046102.70103064
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62963885
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52666159
11Fatty acid degradation_Homo sapiens_hsa000712.50658959
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46239908
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26256965
14Butanoate metabolism_Homo sapiens_hsa006502.18684893
15Peroxisome_Homo sapiens_hsa041462.11832559
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07923752
17Propanoate metabolism_Homo sapiens_hsa006402.03291895
18Chemical carcinogenesis_Homo sapiens_hsa052041.92938683
19PPAR signaling pathway_Homo sapiens_hsa033201.90671793
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90222760
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.87128798
22Histidine metabolism_Homo sapiens_hsa003401.85186950
23Fatty acid metabolism_Homo sapiens_hsa012121.85106116
24Staphylococcus aureus infection_Homo sapiens_hsa051501.79552031
25beta-Alanine metabolism_Homo sapiens_hsa004101.74412494
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70616314
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.68959462
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67994521
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63504754
30Retinol metabolism_Homo sapiens_hsa008301.62732630
31Caffeine metabolism_Homo sapiens_hsa002321.62244515
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61296309
33Selenocompound metabolism_Homo sapiens_hsa004501.59489955
34Bile secretion_Homo sapiens_hsa049761.53183558
35Phenylalanine metabolism_Homo sapiens_hsa003601.49119658
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41884246
37Pyruvate metabolism_Homo sapiens_hsa006201.40847582
38Tyrosine metabolism_Homo sapiens_hsa003501.36554568
39Fatty acid elongation_Homo sapiens_hsa000621.30520864
40Sulfur metabolism_Homo sapiens_hsa009201.30243059
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29207063
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.26914254
43Biosynthesis of amino acids_Homo sapiens_hsa012301.18676703
44ABC transporters_Homo sapiens_hsa020101.18123733
45Folate biosynthesis_Homo sapiens_hsa007901.17515904
46Carbon metabolism_Homo sapiens_hsa012001.16471086
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.15723457
48Fat digestion and absorption_Homo sapiens_hsa049751.09732109
49Steroid biosynthesis_Homo sapiens_hsa001001.09670319
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09000568
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07908530
52Phototransduction_Homo sapiens_hsa047441.06116374
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96864584
54Vitamin digestion and absorption_Homo sapiens_hsa049770.96350581
55Sulfur relay system_Homo sapiens_hsa041220.96342320
56Arginine and proline metabolism_Homo sapiens_hsa003300.94935401
57Vitamin B6 metabolism_Homo sapiens_hsa007500.93133396
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91382104
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.90905320
60Lysine degradation_Homo sapiens_hsa003100.86398406
61Glycerolipid metabolism_Homo sapiens_hsa005610.73686695
62Glutathione metabolism_Homo sapiens_hsa004800.72751779
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70044426
64One carbon pool by folate_Homo sapiens_hsa006700.69454967
65Pentose phosphate pathway_Homo sapiens_hsa000300.62150257
66Fatty acid biosynthesis_Homo sapiens_hsa000610.56183969
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56096461
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55736278
69Nicotine addiction_Homo sapiens_hsa050330.54478541
70Circadian rhythm_Homo sapiens_hsa047100.46857019
71Metabolic pathways_Homo sapiens_hsa011000.44914223
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40729045
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38036976
74Collecting duct acid secretion_Homo sapiens_hsa049660.36011204
75Synaptic vesicle cycle_Homo sapiens_hsa047210.32235037
76Prion diseases_Homo sapiens_hsa050200.30294474
77* GABAergic synapse_Homo sapiens_hsa047270.27253539
78Fructose and mannose metabolism_Homo sapiens_hsa000510.26448424
79Pertussis_Homo sapiens_hsa051330.25218580
80Galactose metabolism_Homo sapiens_hsa000520.24576371
81Insulin resistance_Homo sapiens_hsa049310.24311483
82Gastric acid secretion_Homo sapiens_hsa049710.24137877
83Amphetamine addiction_Homo sapiens_hsa050310.23938996
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.23849897
85Cocaine addiction_Homo sapiens_hsa050300.23040610
86Glutamatergic synapse_Homo sapiens_hsa047240.21095078
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20413210
88Insulin secretion_Homo sapiens_hsa049110.19682090
89Morphine addiction_Homo sapiens_hsa050320.19574121
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18977538
91Other glycan degradation_Homo sapiens_hsa005110.18796375
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15639587
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.14351778
94Linoleic acid metabolism_Homo sapiens_hsa005910.14026412
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.14020338
96Serotonergic synapse_Homo sapiens_hsa047260.13220402
97Circadian entrainment_Homo sapiens_hsa047130.12271712
98cAMP signaling pathway_Homo sapiens_hsa040240.12174587
99HIF-1 signaling pathway_Homo sapiens_hsa040660.11650415
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10792232
101Glucagon signaling pathway_Homo sapiens_hsa049220.07538826
102AMPK signaling pathway_Homo sapiens_hsa041520.03920895
103Mineral absorption_Homo sapiens_hsa04978-0.2383659
104Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2376448
105Lysosome_Homo sapiens_hsa04142-0.2298601
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2025364
107Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1995128
108Amoebiasis_Homo sapiens_hsa05146-0.1882907
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1819649
110Protein digestion and absorption_Homo sapiens_hsa04974-0.1760547
111Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1662114
112Hepatitis C_Homo sapiens_hsa05160-0.1610823
113Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1388600
114Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1368058
115Regulation of autophagy_Homo sapiens_hsa04140-0.1346524
116Renin-angiotensin system_Homo sapiens_hsa04614-0.1289585
117Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1275339
118Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1102796
119Insulin signaling pathway_Homo sapiens_hsa04910-0.1077277
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1046304
121African trypanosomiasis_Homo sapiens_hsa05143-0.0856024
122Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0745793
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0490325

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