SLC6A16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome assembly (GO:0001675)9.77049606
2cell wall macromolecule metabolic process (GO:0044036)9.53324634
3cell wall macromolecule catabolic process (GO:0016998)9.53324634
4multicellular organism reproduction (GO:0032504)9.33743363
5binding of sperm to zona pellucida (GO:0007339)9.14516344
6axonemal dynein complex assembly (GO:0070286)9.07247136
7cell-cell recognition (GO:0009988)8.94270653
8epithelial cilium movement (GO:0003351)8.75836861
9spermatid development (GO:0007286)8.52136102
10plasma membrane fusion (GO:0045026)8.45685155
11motile cilium assembly (GO:0044458)8.34425676
12piRNA metabolic process (GO:0034587)8.06691733
13reproduction (GO:0000003)7.91421201
14regulation of cilium movement (GO:0003352)7.70835618
15cilium movement (GO:0003341)7.48780664
16male meiosis (GO:0007140)7.25556698
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.04472129
18synaptonemal complex organization (GO:0070193)6.98579021
19sperm capacitation (GO:0048240)6.93460816
20synaptonemal complex assembly (GO:0007130)6.75901340
21single fertilization (GO:0007338)6.36293543
22negative regulation of inclusion body assembly (GO:0090084)6.12379104
23organic cation transport (GO:0015695)5.81403534
24spermatogenesis (GO:0007283)5.60081261
25male gamete generation (GO:0048232)5.57838998
26fertilization (GO:0009566)5.50338797
27regulation of inclusion body assembly (GO:0090083)5.25009209
28gamete generation (GO:0007276)5.10536013
29calcium ion-dependent exocytosis (GO:0017156)5.08283889
30male meiosis I (GO:0007141)5.03478029
31ventricular system development (GO:0021591)4.91319719
32DNA methylation involved in gamete generation (GO:0043046)4.83528706
33microtubule depolymerization (GO:0007019)4.80932592
34germ cell development (GO:0007281)4.72856276
35regulation of microtubule-based movement (GO:0060632)4.70361004
36behavioral response to nicotine (GO:0035095)4.66855597
37chromosome organization involved in meiosis (GO:0070192)4.66132643
38cellular process involved in reproduction in multicellular organism (GO:0022412)4.65489624
39microtubule severing (GO:0051013)4.58563288
40seminiferous tubule development (GO:0072520)4.46006055
41cell recognition (GO:0008037)4.45974185
42response to pheromone (GO:0019236)4.30421743
43left/right pattern formation (GO:0060972)4.20931745
44retinal cone cell development (GO:0046549)4.19372185
45cellular ketone body metabolic process (GO:0046950)4.13492827
46amino-acid betaine transport (GO:0015838)4.12130748
47carnitine transport (GO:0015879)4.12130748
48meiotic nuclear division (GO:0007126)4.11105923
49carnitine transmembrane transport (GO:1902603)4.09206493
50multicellular organismal reproductive process (GO:0048609)4.03035275
51meiosis I (GO:0007127)4.00972872
52protein localization to cilium (GO:0061512)3.82194433
53glycerol ether metabolic process (GO:0006662)3.78856049
54chaperone-mediated protein complex assembly (GO:0051131)3.75042435
55spermatid nucleus differentiation (GO:0007289)3.66944448
56ketone body metabolic process (GO:1902224)3.61388814
57platelet dense granule organization (GO:0060155)3.58710718
58cilium assembly (GO:0042384)3.57887225
59protein polyglutamylation (GO:0018095)3.52424314
60alditol metabolic process (GO:0019400)3.49469851
61ether metabolic process (GO:0018904)3.48415493
62chromosome condensation (GO:0030261)3.45782966
63cilium morphogenesis (GO:0060271)3.45481288
64peptidyl-glutamic acid modification (GO:0018200)3.43363480
65peptidyl-histidine modification (GO:0018202)3.39679350
66preassembly of GPI anchor in ER membrane (GO:0016254)3.36988574
67centriole replication (GO:0007099)3.35443693
68somite development (GO:0061053)3.35262865
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33408862
70genitalia morphogenesis (GO:0035112)3.31657727
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.31371441
72NADH dehydrogenase complex assembly (GO:0010257)3.31371441
73mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31371441
74DNA packaging (GO:0006323)3.29658734
75protein complex biogenesis (GO:0070271)3.25337152
76meiotic cell cycle (GO:0051321)3.22748945
77glycolytic process (GO:0006096)3.21794598
78multicellular organismal development (GO:0007275)3.15429513
79resolution of meiotic recombination intermediates (GO:0000712)3.15390672
80nonmotile primary cilium assembly (GO:0035058)3.13097921
81photoreceptor cell maintenance (GO:0045494)3.10074886
82glycerol metabolic process (GO:0006071)3.07778162
83mitochondrial respiratory chain complex assembly (GO:0033108)3.03531773
84synapsis (GO:0007129)3.03263668
85quaternary ammonium group transport (GO:0015697)3.02848241
86indolalkylamine metabolic process (GO:0006586)3.01730815
87microtubule bundle formation (GO:0001578)2.98268147
88respiratory chain complex IV assembly (GO:0008535)2.95401629
89lactate metabolic process (GO:0006089)2.95096186
90negative regulation of mast cell activation (GO:0033004)2.95089610
91left/right axis specification (GO:0070986)2.94606642
92negative regulation of organelle assembly (GO:1902116)2.94200269
93sexual reproduction (GO:0019953)2.93293634
94establishment of protein localization to Golgi (GO:0072600)2.92653556
95neural tube formation (GO:0001841)2.92109897
96indole-containing compound catabolic process (GO:0042436)2.91170402
97indolalkylamine catabolic process (GO:0046218)2.91170402
98tryptophan catabolic process (GO:0006569)2.91170402
99L-fucose catabolic process (GO:0042355)2.89712990
100fucose catabolic process (GO:0019317)2.89712990
101L-fucose metabolic process (GO:0042354)2.89712990
102GPI anchor metabolic process (GO:0006505)2.87782996
103aspartate family amino acid catabolic process (GO:0009068)2.85838360
104protein targeting to Golgi (GO:0000042)2.83464543
105positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.82273789
106microtubule-based movement (GO:0007018)2.81613643
107DNA deamination (GO:0045006)2.80363433
108cellular component assembly involved in morphogenesis (GO:0010927)2.78792025
109pyrimidine nucleobase catabolic process (GO:0006208)2.78198877
110negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77936059
111smoothened signaling pathway (GO:0007224)2.77370727
112urea cycle (GO:0000050)2.75275462
113urea metabolic process (GO:0019627)2.75275462
114protein refolding (GO:0042026)2.74749945
115cell proliferation in forebrain (GO:0021846)2.74099417
116fructose metabolic process (GO:0006000)2.72286680
117polyol catabolic process (GO:0046174)2.71122793
118gene silencing by RNA (GO:0031047)2.69135371
119retinal rod cell development (GO:0046548)2.69123385
120amino-acid betaine metabolic process (GO:0006577)2.69045038
121forebrain morphogenesis (GO:0048853)2.67921243
122regulation of meiosis I (GO:0060631)2.67198836
123single strand break repair (GO:0000012)2.66601634
124centriole assembly (GO:0098534)2.65829956
125photoreceptor cell development (GO:0042461)2.63710485
126transmission of nerve impulse (GO:0019226)2.63376170
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63169849
128L-phenylalanine catabolic process (GO:0006559)2.61430901
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.61430901
130nucleoside diphosphate phosphorylation (GO:0006165)2.59034956
131meiotic cell cycle process (GO:1903046)2.58335468
132GPI anchor biosynthetic process (GO:0006506)2.58325887
133cornea development in camera-type eye (GO:0061303)2.57716559
134cilium organization (GO:0044782)2.56686151
135monoubiquitinated protein deubiquitination (GO:0035520)2.56663623
136carnitine metabolic process (GO:0009437)2.56105919
137intraciliary transport (GO:0042073)2.55737901
138inositol phosphate dephosphorylation (GO:0046855)2.55595773
139phosphorylated carbohydrate dephosphorylation (GO:0046838)2.55595773
140tricarboxylic acid cycle (GO:0006099)2.54087409
141inositol phosphate catabolic process (GO:0071545)2.53841389
142regulation of translation, ncRNA-mediated (GO:0045974)2.53777665
143negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53777665
144negative regulation of translation, ncRNA-mediated (GO:0040033)2.53777665
145axoneme assembly (GO:0035082)2.53644497
146substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.53538947
147substrate-independent telencephalic tangential migration (GO:0021826)2.53538947
148cytochrome complex assembly (GO:0017004)2.53492297
149reciprocal meiotic recombination (GO:0007131)2.52116817
150reciprocal DNA recombination (GO:0035825)2.52116817
151nitrogen cycle metabolic process (GO:0071941)2.49881850
152alpha-linolenic acid metabolic process (GO:0036109)2.49418812
153meiotic chromosome segregation (GO:0045132)2.49015668
154amine catabolic process (GO:0009310)2.48554436
155cellular biogenic amine catabolic process (GO:0042402)2.48554436
156protein localization to Golgi apparatus (GO:0034067)2.47880282
157retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47515694
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.46802214
159exogenous drug catabolic process (GO:0042738)2.46775737
160positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.46281288
161erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.46150800
162L-phenylalanine metabolic process (GO:0006558)2.46150800
163microtubule polymerization or depolymerization (GO:0031109)2.45717678
164carnitine shuttle (GO:0006853)2.45461187
165pyruvate metabolic process (GO:0006090)2.44535876
166sperm motility (GO:0030317)12.0295599
167cilium or flagellum-dependent cell motility (GO:0001539)11.0450508
168fusion of sperm to egg plasma membrane (GO:0007342)10.8648930
169acrosome reaction (GO:0007340)10.7161642
170sperm-egg recognition (GO:0035036)10.0239727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.65543029
2EZH2_22144423_ChIP-Seq_EOC_Human5.24608413
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.32173657
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.81147391
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.76055866
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52652960
7FUS_26573619_Chip-Seq_HEK293_Human2.46079951
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44430696
9VDR_22108803_ChIP-Seq_LS180_Human2.29754659
10GBX2_23144817_ChIP-Seq_PC3_Human2.29020866
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28918751
12IGF1R_20145208_ChIP-Seq_DFB_Human2.25799972
13ZNF274_21170338_ChIP-Seq_K562_Hela2.05881256
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04401995
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96585230
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94631181
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.92452529
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89598271
19P300_19829295_ChIP-Seq_ESCs_Human1.88539567
20ER_23166858_ChIP-Seq_MCF-7_Human1.84371988
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82370073
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.81095901
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.79444967
24EWS_26573619_Chip-Seq_HEK293_Human1.79238149
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79184917
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74723242
27CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.73171420
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.70076414
29IRF1_19129219_ChIP-ChIP_H3396_Human1.68242879
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.66017166
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64425300
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64091322
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60277532
34REST_21632747_ChIP-Seq_MESCs_Mouse1.59553498
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58683426
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.58058145
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.54166580
38KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53941915
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.53526250
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51992012
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50653693
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50275355
43STAT1_17558387_ChIP-Seq_HELA_Human1.50141252
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49727537
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49497043
46MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49195895
47BCAT_22108803_ChIP-Seq_LS180_Human1.48910041
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48902299
49SMAD4_21799915_ChIP-Seq_A2780_Human1.48077434
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46698372
51* TP53_22573176_ChIP-Seq_HFKS_Human1.46009278
52FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45457924
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44407579
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44403341
55STAT3_23295773_ChIP-Seq_U87_Human1.44394891
56AR_25329375_ChIP-Seq_VCAP_Human1.43280135
57CBP_20019798_ChIP-Seq_JUKART_Human1.41895017
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41895017
59NANOG_19829295_ChIP-Seq_ESCs_Human1.38877119
60SOX2_19829295_ChIP-Seq_ESCs_Human1.38877119
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38245093
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37626752
63TCF4_23295773_ChIP-Seq_U87_Human1.37609775
64RNF2_27304074_Chip-Seq_NSC_Mouse1.36442904
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36105081
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.35692288
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.35563061
68TAF15_26573619_Chip-Seq_HEK293_Human1.35457343
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34882083
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34849112
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31177692
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31159590
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30736355
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30522678
75LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30047759
76KDM2B_26808549_Chip-Seq_REH_Human1.30020198
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29575523
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29079518
79MYC_18940864_ChIP-ChIP_HL60_Human1.28882648
80NANOG_20526341_ChIP-Seq_ESCs_Human1.28847780
81WDR5_24793694_ChIP-Seq_LNCAP_Human1.28751190
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28712470
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28319385
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.27963097
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.26211584
86GATA3_21867929_ChIP-Seq_CD8_Mouse1.25043603
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24277474
88GABP_17652178_ChIP-ChIP_JURKAT_Human1.23391079
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22862457
90RUNX2_22187159_ChIP-Seq_PCA_Human1.22078963
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.21453708
92GATA3_21878914_ChIP-Seq_MCF-7_Human1.20429114
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.20357446
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20357446
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.20285928
96P53_21459846_ChIP-Seq_SAOS-2_Human1.19962110
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18119104
98SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16841319
99TCF4_22108803_ChIP-Seq_LS180_Human1.16255879
100NCOR_22424771_ChIP-Seq_293T_Human1.16011588
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15853334
102AR_20517297_ChIP-Seq_VCAP_Human1.15485554
103AR_21572438_ChIP-Seq_LNCaP_Human1.15214709
104RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14455210
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13955786
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13640763
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13282488
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.12867714
109GATA3_21867929_ChIP-Seq_TH1_Mouse1.12156596
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12031614
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12031614
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09537899
113FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09357558
114ERA_21632823_ChIP-Seq_H3396_Human1.07120120
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07111414
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.06751080
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06152883
118HOXB7_26014856_ChIP-Seq_BT474_Human1.05955137
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05306115
120ESET_19884257_ChIP-Seq_ESCs_Mouse1.03509574
121TAF2_19829295_ChIP-Seq_ESCs_Human1.03365109
122FOXH1_21741376_ChIP-Seq_EPCs_Human1.02794817
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.02153865
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01871154
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.01828890
126RARA_24833708_ChIP-Seq_LIVER_Mouse1.01694881
127MYC_27129775_Chip-Seq_CORNEA_Mouse1.01446991
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00655769
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00253224
130SPI1_26923725_Chip-Seq_HPCs_Mouse0.99605062
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99167446
132EST1_17652178_ChIP-ChIP_JURKAT_Human0.98298506
133RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98186306
134SMRT_27268052_Chip-Seq_Bcells_Human0.97704597
135EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97628344
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97372828
137* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97220824
138GF1_26923725_Chip-Seq_HPCs_Mouse0.94711306
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93767026
140RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93652773
141SOX2_21211035_ChIP-Seq_LN229_Human0.93298600
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.93116591
143EZH2_27294783_Chip-Seq_ESCs_Mouse0.92347916
144CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92083298
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.91831138
146OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90422745
147DROSHA_22980978_ChIP-Seq_HELA_Human0.90283691
148NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89805018
149ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89799630
150OCT4_18555785_Chip-Seq_ESCs_Mouse0.89739562
151* ERG_20517297_ChIP-Seq_VCAP_Human0.88651125
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88602452
153CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87799704
154CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87289617
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86920990
156MYC_19829295_ChIP-Seq_ESCs_Human0.86121712
157P53_22387025_ChIP-Seq_ESCs_Mouse0.85880222
158CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84746672
159YY1_22570637_ChIP-Seq_MALME-3M_Human0.84414901
160SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83909270
161CTCF_27219007_Chip-Seq_Bcells_Human0.83451075
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.82955942
163ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82698443
164P300_18555785_Chip-Seq_ESCs_Mouse0.82662445
165TET1_21451524_ChIP-Seq_MESCs_Mouse0.82509058
166ELF1_20517297_ChIP-Seq_JURKAT_Human0.82079828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.01911298
2MP0001929_abnormal_gametogenesis4.48389733
3MP0006292_abnormal_olfactory_placode3.82498524
4MP0008877_abnormal_DNA_methylation3.81443716
5MP0002139_abnormal_hepatobiliary_system3.45485561
6MP0002161_abnormal_fertility/fecundity2.76120669
7MP0002210_abnormal_sex_determination2.76040566
8MP0005360_urolithiasis2.74461757
9MP0005085_abnormal_gallbladder_physiolo2.69593015
10MP0005365_abnormal_bile_salt2.55560950
11MP0002653_abnormal_ependyma_morphology2.53486688
12MP0001986_abnormal_taste_sensitivity2.45317327
13MP0003646_muscle_fatigue2.43957618
14MP0005670_abnormal_white_adipose2.42409392
15MP0001145_abnormal_male_reproductive2.36642275
16MP0008875_abnormal_xenobiotic_pharmacok2.34163108
17MP0002102_abnormal_ear_morphology2.13389243
18MP0002928_abnormal_bile_duct2.08262127
19MP0005623_abnormal_meninges_morphology2.06377764
20MP0008789_abnormal_olfactory_epithelium2.06303212
21MP0000653_abnormal_sex_gland2.05229549
22MP0002163_abnormal_gland_morphology2.04158818
23MP0003787_abnormal_imprinting2.02849713
24MP0005410_abnormal_fertilization13.4739643
25MP0002638_abnormal_pupillary_reflex1.99720391
26MP0009046_muscle_twitch1.91675385
27MP0000372_irregular_coat_pigmentation1.85842209
28MP0009379_abnormal_foot_pigmentation1.82265845
29MP0005253_abnormal_eye_physiology1.80882357
30MP0005379_endocrine/exocrine_gland_phen1.77977619
31MP0005423_abnormal_somatic_nervous1.71186490
32MP0005084_abnormal_gallbladder_morpholo1.71118610
33MP0006072_abnormal_retinal_apoptosis1.71011500
34MP0003718_maternal_effect1.60874687
35MP0003136_yellow_coat_color1.59211979
36MP0002837_dystrophic_cardiac_calcinosis1.58622278
37MP0005394_taste/olfaction_phenotype1.56783866
38MP0005499_abnormal_olfactory_system1.56783866
39MP0000631_abnormal_neuroendocrine_gland1.56617058
40MP0001485_abnormal_pinna_reflex1.54389359
41MP0002938_white_spotting1.53532365
42MP0003806_abnormal_nucleotide_metabolis1.48227178
43MP0005645_abnormal_hypothalamus_physiol1.46176706
44MP0004233_abnormal_muscle_weight1.43168012
45MP0010329_abnormal_lipoprotein_level1.39597198
46MP0003252_abnormal_bile_duct1.38742977
47MP0004133_heterotaxia1.38178742
48MP0005174_abnormal_tail_pigmentation1.38171724
49MP0003122_maternal_imprinting1.33997478
50MP0005646_abnormal_pituitary_gland1.33324273
51MP0002160_abnormal_reproductive_system1.31944792
52MP0003121_genomic_imprinting1.31559711
53MP0003329_amyloid_beta_deposits1.28406110
54MP0003880_abnormal_central_pattern1.19429447
55MP0002132_abnormal_respiratory_system1.15348600
56MP0006036_abnormal_mitochondrial_physio1.15002089
57MP0000778_abnormal_nervous_system1.14563127
58MP0001293_anophthalmia1.14377068
59MP0000427_abnormal_hair_cycle1.13708562
60MP0000049_abnormal_middle_ear1.12584356
61MP0003195_calcinosis1.11655867
62MP0005195_abnormal_posterior_eye1.11286361
63MP0005647_abnormal_sex_gland1.09933747
64MP0004142_abnormal_muscle_tone1.08292239
65MP0001984_abnormal_olfaction1.07508982
66MP0002557_abnormal_social/conspecific_i1.06114322
67MP0000026_abnormal_inner_ear1.05542103
68MP0005332_abnormal_amino_acid1.04524776
69MP0008872_abnormal_physiological_respon1.03278571
70MP0006035_abnormal_mitochondrial_morpho0.98775055
71MP0001764_abnormal_homeostasis0.98241409
72MP0004036_abnormal_muscle_relaxation0.98201338
73MP0005391_vision/eye_phenotype0.97625081
74MP0002282_abnormal_trachea_morphology0.97380015
75MP0001765_abnormal_ion_homeostasis0.96421997
76MP0002118_abnormal_lipid_homeostasis0.96265833
77MP0002752_abnormal_somatic_nervous0.95819155
78MP0002095_abnormal_skin_pigmentation0.95304066
79MP0003938_abnormal_ear_development0.94958534
80MP0002735_abnormal_chemical_nociception0.94002547
81MP0002138_abnormal_hepatobiliary_system0.92435855
82MP0001905_abnormal_dopamine_level0.91698666
83MP0000751_myopathy0.90701457
84MP0002751_abnormal_autonomic_nervous0.89831672
85MP0004130_abnormal_muscle_cell0.89254040
86MP0002733_abnormal_thermal_nociception0.88607163
87MP0002909_abnormal_adrenal_gland0.88013369
88MP0000604_amyloidosis0.87674527
89MP0002277_abnormal_respiratory_mucosa0.87617560
90MP0004019_abnormal_vitamin_homeostasis0.87230016
91MP0001970_abnormal_pain_threshold0.86774861
92MP0001963_abnormal_hearing_physiology0.85748893
93MP0005083_abnormal_biliary_tract0.84968598
94MP0004742_abnormal_vestibular_system0.84805556
95MP0003119_abnormal_digestive_system0.82445239
96MP0002184_abnormal_innervation0.81891352
97MP0001502_abnormal_circadian_rhythm0.81280347
98MP0005319_abnormal_enzyme/_coenzyme0.81238657
99MP0002269_muscular_atrophy0.78444541
100MP0008058_abnormal_DNA_repair0.78209393
101MP0001324_abnormal_eye_pigmentation0.77336544
102MP0009840_abnormal_foam_cell0.77175206
103MP0000015_abnormal_ear_pigmentation0.75925250
104MP0003937_abnormal_limbs/digits/tail_de0.75059864
105MP0005584_abnormal_enzyme/coenzyme_acti0.75002381
106MP0003011_delayed_dark_adaptation0.72082195
107MP0005636_abnormal_mineral_homeostasis0.71462069
108MP0000609_abnormal_liver_physiology0.71292723
109MP0002233_abnormal_nose_morphology0.70833703
110MP0002822_catalepsy0.67033636
111MP0003635_abnormal_synaptic_transmissio0.66388652
112MP0001968_abnormal_touch/_nociception0.65554925
113MP0001529_abnormal_vocalization0.64934093
114MP0005266_abnormal_metabolism0.63607636
115MP0000358_abnormal_cell_content/0.63220413
116MP0002736_abnormal_nociception_after0.62883956
117MP0009745_abnormal_behavioral_response0.60960377
118MP0002064_seizures0.60469090
119MP0002572_abnormal_emotion/affect_behav0.60220924
120MP0005666_abnormal_adipose_tissue0.58474869
121MP0002971_abnormal_brown_adipose0.57804812
122MP0002272_abnormal_nervous_system0.57751259
123MP0005535_abnormal_body_temperature0.57493414
124MP0001440_abnormal_grooming_behavior0.57177599
125MP0002063_abnormal_learning/memory/cond0.55929991
126MP0004084_abnormal_cardiac_muscle0.55869669
127MP0004270_analgesia0.54819660
128MP0004215_abnormal_myocardial_fiber0.54085950
129MP0006276_abnormal_autonomic_nervous0.52840517
130MP0001666_abnormal_nutrient_absorption0.52551684
131MP0003633_abnormal_nervous_system0.51610551
132MP0005389_reproductive_system_phenotype0.51184196
133MP0003868_abnormal_feces_composition0.48609342
134MP0003115_abnormal_respiratory_system0.47921492
135MP0005551_abnormal_eye_electrophysiolog0.47800281
136MP0006138_congestive_heart_failure0.47796060
137MP0005451_abnormal_body_composition0.46360665
138MP0002876_abnormal_thyroid_physiology0.46041288
139MP0005376_homeostasis/metabolism_phenot0.45550159
140MP0001486_abnormal_startle_reflex0.44914483
141MP0002067_abnormal_sensory_capabilities0.42883031
142MP0003631_nervous_system_phenotype0.42424130
143MP0002234_abnormal_pharynx_morphology0.40602386
144MP0002229_neurodegeneration0.40132834
145MP0005330_cardiomyopathy0.39925107
146MP0003699_abnormal_female_reproductive0.39654831
147MP0004085_abnormal_heartbeat0.38212683
148MP0004087_abnormal_muscle_fiber0.37717723
149MP0003950_abnormal_plasma_membrane0.37469878
150MP0002078_abnormal_glucose_homeostasis0.36753218
151MP0004043_abnormal_pH_regulation0.36571104
152MP0004145_abnormal_muscle_electrophysio0.36503637
153MP0002332_abnormal_exercise_endurance0.36501118
154MP0003879_abnormal_hair_cell0.36363250
155MP0009115_abnormal_fat_cell0.35393532
156MP0003878_abnormal_ear_physiology0.34291550
157MP0005377_hearing/vestibular/ear_phenot0.34291550
158MP0001727_abnormal_embryo_implantation0.34141692
159MP0003191_abnormal_cellular_cholesterol0.32920342
160MP0008995_early_reproductive_senescence0.32895472

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.47985941
2Abnormal respiratory epithelium morphology (HP:0012253)8.03642926
3Abnormal respiratory motile cilium morphology (HP:0005938)8.03642926
4Rhinitis (HP:0012384)7.02140178
5Abnormal ciliary motility (HP:0012262)6.71481988
6Chronic bronchitis (HP:0004469)6.43303987
7Infertility (HP:0000789)6.36787184
8Nasal polyposis (HP:0100582)5.64240390
9Chronic hepatic failure (HP:0100626)4.70899512
10Abnormality of the nasal mucosa (HP:0000433)4.66882754
11Pancreatic cysts (HP:0001737)4.52847416
12Pancreatic fibrosis (HP:0100732)4.30249163
13Nephronophthisis (HP:0000090)3.97821060
14True hermaphroditism (HP:0010459)3.92203055
15Bronchitis (HP:0012387)3.87395905
16Bronchiectasis (HP:0002110)3.85900279
17Male infertility (HP:0003251)3.79518374
18Abnormal rod and cone electroretinograms (HP:0008323)3.23723990
19Cystic liver disease (HP:0006706)3.17885576
20Abnormal gallbladder physiology (HP:0012438)3.16893744
21Cholecystitis (HP:0001082)3.16893744
22Congenital stationary night blindness (HP:0007642)3.09443055
23Absent rod-and cone-mediated responses on ERG (HP:0007688)3.07991189
24Abnormal spermatogenesis (HP:0008669)3.07209690
25Abnormality of the lower motor neuron (HP:0002366)3.03109451
26Recurrent otitis media (HP:0000403)2.94417707
27Abnormality of the renal medulla (HP:0100957)2.88709346
28Bony spicule pigmentary retinopathy (HP:0007737)2.77869795
29Type II lissencephaly (HP:0007260)2.72463847
30Anencephaly (HP:0002323)2.69138431
31Recurrent sinusitis (HP:0011108)2.66629779
32Gonadotropin excess (HP:0000837)2.66301680
33Occipital encephalocele (HP:0002085)2.64532743
34Gait imbalance (HP:0002141)2.60268472
35Attenuation of retinal blood vessels (HP:0007843)2.59196592
36Congenital primary aphakia (HP:0007707)2.53101280
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.52152873
38Sclerocornea (HP:0000647)2.50762133
39Tubulointerstitial nephritis (HP:0001970)2.49754601
40Impulsivity (HP:0100710)2.43848917
41Nephrogenic diabetes insipidus (HP:0009806)2.40250745
42Molar tooth sign on MRI (HP:0002419)2.30404931
43Abnormality of midbrain morphology (HP:0002418)2.30404931
44Azoospermia (HP:0000027)2.29363521
45Tubulointerstitial abnormality (HP:0001969)2.29274925
46Spastic tetraparesis (HP:0001285)2.25467001
47Genital tract atresia (HP:0001827)2.19845882
48Vaginal atresia (HP:0000148)2.17403819
49Tubular atrophy (HP:0000092)2.17063405
50Recurrent bronchitis (HP:0002837)2.16790518
51Abolished electroretinogram (ERG) (HP:0000550)2.16134182
52Medial flaring of the eyebrow (HP:0010747)2.15875738
53Cerebellar dysplasia (HP:0007033)2.15106155
54Abnormality of macular pigmentation (HP:0008002)2.08558012
55Acute necrotizing encephalopathy (HP:0006965)2.08094247
56Severe visual impairment (HP:0001141)2.07956465
57Deep venous thrombosis (HP:0002625)2.06526267
58Male pseudohermaphroditism (HP:0000037)2.06410763
59Mitochondrial inheritance (HP:0001427)2.05174806
60Supernumerary spleens (HP:0009799)2.03920396
61Polyuria (HP:0000103)2.02108860
62Myoglobinuria (HP:0002913)2.00864681
63Postaxial hand polydactyly (HP:0001162)2.00045718
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2596370
65Dynein arm defect of respiratory motile cilia (HP:0012255)11.7723863
66Absent/shortened dynein arms (HP:0200106)11.7723863
67Amyotrophic lateral sclerosis (HP:0007354)1.99930507
68Lissencephaly (HP:0001339)1.99580002
69Pendular nystagmus (HP:0012043)1.99079847
70Bile duct proliferation (HP:0001408)1.98827276
71Abnormal biliary tract physiology (HP:0012439)1.98827276
72Increased CSF lactate (HP:0002490)1.95540298
73Exercise-induced myalgia (HP:0003738)1.94842534
74Lipid accumulation in hepatocytes (HP:0006561)1.94720191
75Poor coordination (HP:0002370)1.93989724
76Tubulointerstitial fibrosis (HP:0005576)1.92937222
77Neurofibrillary tangles (HP:0002185)1.91708420
78Hypercholesterolemia (HP:0003124)1.91438874
79Abnormality of the labia minora (HP:0012880)1.90897232
80Oligodactyly (hands) (HP:0001180)1.90003305
81Impaired proprioception (HP:0010831)1.88531962
82Optic nerve hypoplasia (HP:0000609)1.87699421
83Hypobetalipoproteinemia (HP:0003563)1.87232972
84Preaxial hand polydactyly (HP:0001177)1.87039029
85Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86730382
86Hepatocellular necrosis (HP:0001404)1.86001166
87Intrahepatic cholestasis (HP:0001406)1.85613999
88Progressive cerebellar ataxia (HP:0002073)1.85571097
89Hemorrhage of the eye (HP:0011885)1.84089696
90Acute encephalopathy (HP:0006846)1.83976067
91Multicystic kidney dysplasia (HP:0000003)1.83923654
92Colon cancer (HP:0003003)1.81496288
93Abnormal mitochondria in muscle tissue (HP:0008316)1.80084135
94Congenital hepatic fibrosis (HP:0002612)1.78881288
95Progressive macrocephaly (HP:0004481)1.78457828
96Renal cortical cysts (HP:0000803)1.78207270
97Intestinal atresia (HP:0011100)1.76682801
98Retinitis pigmentosa (HP:0000510)1.76489962
99Hepatic necrosis (HP:0002605)1.74300034
100Bundle branch block (HP:0011710)1.73941733
101Hypoalphalipoproteinemia (HP:0003233)1.73651741
102Aplasia/Hypoplasia of the spleen (HP:0010451)1.72558600
103Ketosis (HP:0001946)1.72501032
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72175051
105Abnormality of the renal cortex (HP:0011035)1.72079684
106Furrowed tongue (HP:0000221)1.71962437
107Narrow forehead (HP:0000341)1.70988198
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.70730088
109Oculomotor apraxia (HP:0000657)1.70112821
110Optic disc pallor (HP:0000543)1.68837266
111Upper motor neuron abnormality (HP:0002127)1.68756608
112Dandy-Walker malformation (HP:0001305)1.68274954
113Postaxial foot polydactyly (HP:0001830)1.67530021
114Hyperglycinemia (HP:0002154)1.67428410
115Abnormality of monocarboxylic acid metabolism (HP:0010996)1.67044520
116Abnormal urine output (HP:0012590)1.66805145
117Holoprosencephaly (HP:0001360)1.66667733
118Constricted visual fields (HP:0001133)1.66494422
119Hypolipoproteinemia (HP:0010981)1.66378817
120Hyperlipoproteinemia (HP:0010980)1.66349477
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66031201
122Febrile seizures (HP:0002373)1.65948707
123Xanthomatosis (HP:0000991)1.65688745
124Complement deficiency (HP:0004431)1.65102894
125Cerebral inclusion bodies (HP:0100314)1.65061960
126Rhabdomyolysis (HP:0003201)1.63737122
1273-Methylglutaconic aciduria (HP:0003535)1.62941315
128Aganglionic megacolon (HP:0002251)1.62932157
129Anophthalmia (HP:0000528)1.62528700
130Stage 5 chronic kidney disease (HP:0003774)1.60225967
131Prominent nasal bridge (HP:0000426)1.60190696
132Prolonged partial thromboplastin time (HP:0003645)1.59856555
133Renal Fanconi syndrome (HP:0001994)1.59474295
134Dyskinesia (HP:0100660)1.59371264
135Decreased central vision (HP:0007663)1.57546266
136Global brain atrophy (HP:0002283)1.54912835
137Abnormality of saccadic eye movements (HP:0000570)1.53045875
138Vascular calcification (HP:0004934)1.52830389
139Abnormal drinking behavior (HP:0030082)1.52807475
140Polydipsia (HP:0001959)1.52807475
141Hemiparesis (HP:0001269)1.51702920
142Fibular hypoplasia (HP:0003038)1.51239141
143Exercise-induced muscle cramps (HP:0003710)1.50534008
144Decreased electroretinogram (ERG) amplitude (HP:0000654)1.49926564
145Dyschromatopsia (HP:0007641)1.47611219
146Short ribs (HP:0000773)1.46011353
147Hyporeflexia of lower limbs (HP:0002600)1.44401162
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.42505770
149Impaired vibration sensation in the lower limbs (HP:0002166)1.42115942
150Retinal atrophy (HP:0001105)1.39679584
151Asymmetric septal hypertrophy (HP:0001670)1.37896255
152Hyperammonemia (HP:0001987)1.37345676
153Spontaneous abortion (HP:0005268)1.36773257
154Heterotopia (HP:0002282)1.36389550
155Choroideremia (HP:0001139)1.35930402
156Bell-shaped thorax (HP:0001591)1.35562859
157Abnormality of renal excretion (HP:0011036)1.34673175
158Status epilepticus (HP:0002133)1.34574736
159Epidermoid cyst (HP:0200040)1.33258129
160Cardiovascular calcification (HP:0011915)1.32837863
161Abnormality of vision evoked potentials (HP:0000649)1.31308942
162Abnormality of ocular smooth pursuit (HP:0000617)1.30400038
163Focal motor seizures (HP:0011153)1.29979145
164Impaired vibratory sensation (HP:0002495)1.27914031
165Cerebral edema (HP:0002181)1.26721207
166Renal dysplasia (HP:0000110)1.25061913
167Hyperinsulinemic hypoglycemia (HP:0000825)1.24657233
168Pachygyria (HP:0001302)1.23713887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.31282815
2PDK38.31282815
3PDK25.30511912
4TESK15.20612271
5PRKD34.49125219
6ICK3.97381049
7FRK3.81267167
8ADRBK23.15303919
9TIE12.93647941
10PNCK2.86438357
11NUAK12.67194875
12WNK32.54620849
13WNK42.48681414
14ZAK2.40781675
15PTK2B2.34020968
16MAP4K22.31601449
17STK392.31573042
18PLK42.02524767
19GRK12.01697510
20STK381.99956646
21DYRK21.93109625
22TXK1.57663935
23MAPK131.56908704
24BRSK21.47363105
25NEK21.27156712
26PDK11.14622800
27MKNK21.13468964
28TRIM281.13147574
29NME11.05797918
30MAP3K131.05679635
31PLK21.04164222
32DYRK1B1.02411896
33CSNK1G21.02081082
34TGFBR11.01455529
35WNK10.99974751
36MAP3K40.99640953
37TEC0.96960429
38TYRO30.93721027
39CSNK1G10.93441341
40VRK10.93207168
41ADRBK10.93105384
42TLK10.90383875
43FGFR20.89955421
44PINK10.86238828
45TAOK30.84927338
46CASK0.84574412
47MAP2K40.83905845
48ACVR1B0.83513972
49IKBKE0.82941146
50MAPK150.81349759
51CSNK1G30.79723964
52LMTK20.77551241
53CSNK1A1L0.75422318
54SIK20.72532493
55PDPK10.72340620
56STK160.72239445
57PRKCE0.71676190
58ITK0.70871017
59MAP2K70.70578999
60BCKDK0.70519739
61BCR0.68591830
62NTRK20.67491862
63NLK0.67002683
64MST40.66640764
65CAMKK20.66400676
66STK38L0.65557991
67GRK70.61611807
68MUSK0.60418772
69CAMK10.60013604
70RPS6KA50.59486795
71PRKCI0.59179180
72TAF10.58496248
73JAK30.58167068
74PRKCG0.58056772
75CAMK1G0.57962881
76STK30.56228150
77CCNB10.53932446
78TNIK0.52722229
79BRD40.52692504
80MAP3K70.51667649
81TNK20.50835803
82VRK20.50690397
83STK240.48603925
84PLK10.47258994
85TTK0.47184020
86WEE10.46662964
87MYLK0.46513138
88NTRK30.45994192
89BLK0.45920484
90MKNK10.45356759
91IKBKB0.44046299
92DYRK30.43758763
93SGK20.43657014
94LIMK10.39955369
95MARK30.39496937
96SGK4940.39298005
97SGK2230.39298005
98MAP2K60.38749562
99DYRK1A0.38641025
100CDK30.38402689
101CHUK0.37712199
102PRKAA10.33117421
103PAK60.31397302
104PASK0.31050352
105LATS20.30695170
106ERBB40.29439475
107IRAK20.29105309
108CAMK2A0.28876796
109IRAK10.28658312
110MTOR0.28321147
111MINK10.28210886
112CHEK10.27312686
113CAMKK10.26622114
114EPHA40.26347263
115CHEK20.25385368
116PAK10.25321600
117MAP3K120.24974868
118PRKCZ0.24822794
119AKT30.23468386
120MAP3K50.22838517
121STK110.22747636
122PHKG20.22672887
123PHKG10.22672887
124RIPK40.21348125
125TAOK10.20139362
126BRAF0.19956892
127PRKACG0.18557237
128RPS6KB10.17179170
129PRKCQ0.16764638
130MARK10.16376121
131GRK50.16070016
132ATM0.14862073
133MAP3K10.13841735
134EEF2K0.12292107
135PRKG10.12189325
136CAMK2G0.11684888
137PAK20.11572341
138CDC70.11224305
139PRKACB0.10884127
140DAPK20.10760553
141MARK20.10550202
142MAP3K90.10512861
143PRKACA0.09444463
144TTN0.08918242
145RPS6KA30.07657708
146CDK150.07463153
147PRKCB0.05856691
148PRKCA0.05696824
149CDK180.05153543
150INSRR0.05132509
151BMPR1B0.04597170
152PAK30.04006156
153GSK3B0.03974194
154OXSR10.03634183
155CAMK2D0.03210548
156EPHB10.03001056
157CSNK1E0.02753615
158CDK50.02727518
159CDK140.02607435
160NTRK10.02580021
161CDK11A0.02164440
162MAPK80.01771056
163RPS6KA10.01515021

Predicted pathways (KEGG)

RankGene SetZ-score
1Pyruvate metabolism_Homo sapiens_hsa006203.48867030
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14802117
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.14767826
4Propanoate metabolism_Homo sapiens_hsa006403.13695822
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.07737514
6Vitamin B6 metabolism_Homo sapiens_hsa007502.84337138
7Fatty acid biosynthesis_Homo sapiens_hsa000612.63226442
8Phototransduction_Homo sapiens_hsa047442.46808683
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.45515448
10Fatty acid degradation_Homo sapiens_hsa000712.37350050
11PPAR signaling pathway_Homo sapiens_hsa033202.13526743
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13250417
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09697593
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08233925
15Fatty acid metabolism_Homo sapiens_hsa012122.06876564
16Ribosome_Homo sapiens_hsa030102.04582724
17Carbon metabolism_Homo sapiens_hsa012002.00386754
18Fanconi anemia pathway_Homo sapiens_hsa034601.95814696
19Nitrogen metabolism_Homo sapiens_hsa009101.94070688
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92199607
21Homologous recombination_Homo sapiens_hsa034401.88541089
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.85388082
23Glucagon signaling pathway_Homo sapiens_hsa049221.82751515
24Selenocompound metabolism_Homo sapiens_hsa004501.79221941
25Arginine biosynthesis_Homo sapiens_hsa002201.77044138
26Protein export_Homo sapiens_hsa030601.69275745
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66350794
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66154287
29Olfactory transduction_Homo sapiens_hsa047401.61194211
30Linoleic acid metabolism_Homo sapiens_hsa005911.61091861
31Biosynthesis of amino acids_Homo sapiens_hsa012301.59608935
32RNA polymerase_Homo sapiens_hsa030201.56584189
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56565729
34Huntingtons disease_Homo sapiens_hsa050161.50979106
35Pentose phosphate pathway_Homo sapiens_hsa000301.48115858
36RNA degradation_Homo sapiens_hsa030181.46854627
37Glycerolipid metabolism_Homo sapiens_hsa005611.44741074
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42863454
39Fat digestion and absorption_Homo sapiens_hsa049751.39541779
40Butanoate metabolism_Homo sapiens_hsa006501.39127437
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.39083397
42Cardiac muscle contraction_Homo sapiens_hsa042601.37473374
43Bile secretion_Homo sapiens_hsa049761.36355187
44Regulation of autophagy_Homo sapiens_hsa041401.34992948
45Chemical carcinogenesis_Homo sapiens_hsa052041.32481388
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30897954
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30168306
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29694018
49Arachidonic acid metabolism_Homo sapiens_hsa005901.25584759
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25119617
51Complement and coagulation cascades_Homo sapiens_hsa046101.24451171
52Tryptophan metabolism_Homo sapiens_hsa003801.23146916
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.20397711
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19331633
55Peroxisome_Homo sapiens_hsa041461.18862641
56Dorso-ventral axis formation_Homo sapiens_hsa043201.18287299
57Fructose and mannose metabolism_Homo sapiens_hsa000511.16999323
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16051755
59Asthma_Homo sapiens_hsa053101.14715954
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13756684
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.13316669
62Steroid biosynthesis_Homo sapiens_hsa001001.12755039
63Glycerophospholipid metabolism_Homo sapiens_hsa005641.12620643
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10434565
65Primary immunodeficiency_Homo sapiens_hsa053401.10233523
66Oxidative phosphorylation_Homo sapiens_hsa001901.08748009
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05777334
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03067949
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00898322
70Amphetamine addiction_Homo sapiens_hsa050311.00200002
71Fatty acid elongation_Homo sapiens_hsa000620.95837742
72Collecting duct acid secretion_Homo sapiens_hsa049660.94962339
73Phenylalanine metabolism_Homo sapiens_hsa003600.93669753
74Morphine addiction_Homo sapiens_hsa050320.92585349
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92215547
76ABC transporters_Homo sapiens_hsa020100.91625854
77Retinol metabolism_Homo sapiens_hsa008300.84472337
78Hedgehog signaling pathway_Homo sapiens_hsa043400.83795501
79Autoimmune thyroid disease_Homo sapiens_hsa053200.82913185
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.81464649
81Allograft rejection_Homo sapiens_hsa053300.80951217
82Sulfur metabolism_Homo sapiens_hsa009200.80138173
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79805029
84beta-Alanine metabolism_Homo sapiens_hsa004100.78971002
85Serotonergic synapse_Homo sapiens_hsa047260.78418581
86Synaptic vesicle cycle_Homo sapiens_hsa047210.75597122
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75017621
88Graft-versus-host disease_Homo sapiens_hsa053320.74942674
89Renin secretion_Homo sapiens_hsa049240.74842226
90Parkinsons disease_Homo sapiens_hsa050120.74816792
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73658191
92Oocyte meiosis_Homo sapiens_hsa041140.73482851
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72468938
94Nicotine addiction_Homo sapiens_hsa050330.70049742
95One carbon pool by folate_Homo sapiens_hsa006700.69354688
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69116541
97Type I diabetes mellitus_Homo sapiens_hsa049400.67321357
98GABAergic synapse_Homo sapiens_hsa047270.66602153
99Glutathione metabolism_Homo sapiens_hsa004800.66584069
100Alzheimers disease_Homo sapiens_hsa050100.64721707
101Ovarian steroidogenesis_Homo sapiens_hsa049130.63949514
102Tyrosine metabolism_Homo sapiens_hsa003500.63302554
103Basal transcription factors_Homo sapiens_hsa030220.62716375
104Glutamatergic synapse_Homo sapiens_hsa047240.62233398
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61987238
106Basal cell carcinoma_Homo sapiens_hsa052170.61274182
107Starch and sucrose metabolism_Homo sapiens_hsa005000.61070875
108Histidine metabolism_Homo sapiens_hsa003400.59687173
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59228553
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58517728
111Metabolic pathways_Homo sapiens_hsa011000.57971158
112Long-term potentiation_Homo sapiens_hsa047200.54932422
113Non-homologous end-joining_Homo sapiens_hsa034500.53272434
114Purine metabolism_Homo sapiens_hsa002300.52661587
115Ether lipid metabolism_Homo sapiens_hsa005650.52611377
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.51311315
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48015139
118Insulin secretion_Homo sapiens_hsa049110.47908043
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46857768
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.46102907
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42447088
122Salivary secretion_Homo sapiens_hsa049700.42296606
123Caffeine metabolism_Homo sapiens_hsa002320.41812665
124RNA transport_Homo sapiens_hsa030130.41184498
125Taste transduction_Homo sapiens_hsa047420.39208834
126Arginine and proline metabolism_Homo sapiens_hsa003300.39065457
127Lysine degradation_Homo sapiens_hsa003100.38622218
128Nucleotide excision repair_Homo sapiens_hsa034200.38530239
129Mineral absorption_Homo sapiens_hsa049780.38208608
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38103636
131Sulfur relay system_Homo sapiens_hsa041220.37510118
132Pyrimidine metabolism_Homo sapiens_hsa002400.35976307
133AMPK signaling pathway_Homo sapiens_hsa041520.35722908
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34742899
135Calcium signaling pathway_Homo sapiens_hsa040200.34657037
136Estrogen signaling pathway_Homo sapiens_hsa049150.34027103
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33622229
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33300356
139Mismatch repair_Homo sapiens_hsa034300.32604188
140Cholinergic synapse_Homo sapiens_hsa047250.31985337
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31528044
142Dopaminergic synapse_Homo sapiens_hsa047280.31415975
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.29637619
144Thyroid hormone synthesis_Homo sapiens_hsa049180.26312884
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26045060
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25533062
147Staphylococcus aureus infection_Homo sapiens_hsa051500.24417895
148Circadian entrainment_Homo sapiens_hsa047130.23146886
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23085976
150Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22368922

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