SLC6A19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.37354806
2angiotensin maturation (GO:0002003)9.24297328
3intestinal cholesterol absorption (GO:0030299)8.63545151
4regulation of guanylate cyclase activity (GO:0031282)8.08074961
5drug catabolic process (GO:0042737)6.99031640
6epoxygenase P450 pathway (GO:0019373)6.95963530
7drug transmembrane transport (GO:0006855)6.93106025
8fat-soluble vitamin biosynthetic process (GO:0042362)6.90694414
9drug transport (GO:0015893)6.46605597
10modified amino acid transport (GO:0072337)6.33857233
11regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.29448330
12positive regulation of guanylate cyclase activity (GO:0031284)6.24115840
13urate metabolic process (GO:0046415)5.90810472
14adhesion of symbiont to host cell (GO:0044650)5.81927543
15virion attachment to host cell (GO:0019062)5.81927543
16aminoglycoside antibiotic metabolic process (GO:0030647)5.33687464
17very-low-density lipoprotein particle assembly (GO:0034379)5.22909283
18regulation of systemic arterial blood pressure (GO:0003073)5.13705312
19actin filament depolymerization (GO:0030042)5.12207637
20flavonoid metabolic process (GO:0009812)5.10181339
21lysine catabolic process (GO:0006554)5.07212499
22lysine metabolic process (GO:0006553)5.07212499
23regulation of cellular extravasation (GO:0002691)5.04926991
24vitamin A metabolic process (GO:0006776)5.03396373
25peptide catabolic process (GO:0043171)4.90216288
26regulation of cGMP biosynthetic process (GO:0030826)4.89599152
27exogenous drug catabolic process (GO:0042738)4.85977738
28organic cation transport (GO:0015695)4.85107729
29renal absorption (GO:0070293)4.77178099
30receptor guanylyl cyclase signaling pathway (GO:0007168)4.71758607
31adhesion of symbiont to host (GO:0044406)4.67372803
32phosphate ion transport (GO:0006817)4.64873551
33oligosaccharide catabolic process (GO:0009313)4.50531595
34urea cycle (GO:0000050)4.47910515
35polyol transport (GO:0015791)4.45106105
36sulfur compound transport (GO:0072348)4.36552063
37cellular response to nitric oxide (GO:0071732)4.35471417
38renal system process involved in regulation of blood volume (GO:0001977)4.34011982
39urea metabolic process (GO:0019627)4.28906310
403-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.25756721
41purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.25756721
42excretion (GO:0007588)4.23102311
43bile acid and bile salt transport (GO:0015721)4.21791527
44cellular glucuronidation (GO:0052695)4.21669423
45regulation of bile acid biosynthetic process (GO:0070857)4.18015694
46glucuronate metabolic process (GO:0019585)4.17828830
47uronic acid metabolic process (GO:0006063)4.17828830
48cysteine metabolic process (GO:0006534)4.13904766
49nonribosomal peptide biosynthetic process (GO:0019184)4.13596450
50glycolipid catabolic process (GO:0019377)4.12087615
51NADH metabolic process (GO:0006734)4.10443528
52homocysteine metabolic process (GO:0050667)4.08520747
53vitamin transmembrane transport (GO:0035461)4.08233745
54glycosphingolipid catabolic process (GO:0046479)4.06454741
55regulation of cGMP metabolic process (GO:0030823)4.06318079
56quaternary ammonium group transport (GO:0015697)4.03216017
57regulation of vitamin metabolic process (GO:0030656)3.97974934
58digestive system process (GO:0022600)3.97962656
59hormone catabolic process (GO:0042447)3.97604867
60antibacterial humoral response (GO:0019731)3.96257625
61nitrogen cycle metabolic process (GO:0071941)3.96222028
62glucose 6-phosphate metabolic process (GO:0051156)3.95937584
63sulfate transmembrane transport (GO:1902358)3.94639078
64glutathione biosynthetic process (GO:0006750)3.90396781
65fructose metabolic process (GO:0006000)3.89716369
66antimicrobial humoral response (GO:0019730)3.86064415
67trivalent inorganic anion homeostasis (GO:0072506)3.85052284
68phosphate ion homeostasis (GO:0055062)3.85052284
69phosphate ion transmembrane transport (GO:0035435)3.82802548
70diacylglycerol metabolic process (GO:0046339)3.81418168
71vitamin D metabolic process (GO:0042359)3.79571046
72response to nitric oxide (GO:0071731)3.79173053
73lipoprotein metabolic process (GO:0042157)3.78863147
74alkaloid metabolic process (GO:0009820)3.78687562
75peptide hormone processing (GO:0016486)3.77254145
76phospholipid efflux (GO:0033700)3.75228869
77transepithelial transport (GO:0070633)3.73453823
78fat-soluble vitamin metabolic process (GO:0006775)3.72808060
79response to phenylpropanoid (GO:0080184)3.70048913
80positive regulation of lipoprotein lipase activity (GO:0051006)3.69925635
81positive regulation of triglyceride lipase activity (GO:0061365)3.69925635
82cellular response to reactive nitrogen species (GO:1902170)3.68459032
83digestion (GO:0007586)3.65972856
84positive regulation of pseudopodium assembly (GO:0031274)3.65760074
85maintenance of gastrointestinal epithelium (GO:0030277)3.63900987
86negative regulation of cholesterol transport (GO:0032375)3.61929988
87negative regulation of sterol transport (GO:0032372)3.61929988
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.61349034
89positive regulation of cGMP biosynthetic process (GO:0030828)3.59486589
90cellular carbohydrate catabolic process (GO:0044275)3.58915400
91regulation of triglyceride catabolic process (GO:0010896)3.56661082
92positive regulation of glycoprotein biosynthetic process (GO:0010560)3.54823205
93regulation of cholesterol homeostasis (GO:2000188)3.52545482
94glutamine family amino acid biosynthetic process (GO:0009084)3.51236497
95plasma lipoprotein particle assembly (GO:0034377)3.51178595
96regulation of cholesterol esterification (GO:0010872)3.49845589
97drug metabolic process (GO:0017144)3.48776882
98cellular response to hepatocyte growth factor stimulus (GO:0035729)3.47824820
99response to hepatocyte growth factor (GO:0035728)3.47824820
100negative regulation of digestive system process (GO:0060457)3.47589293
101bicarbonate transport (GO:0015701)3.47374176
102lipoprotein transport (GO:0042953)3.46920930
103fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.46135330
104response to mercury ion (GO:0046689)3.45497352
105drinking behavior (GO:0042756)3.45466690
106tricarboxylic acid metabolic process (GO:0072350)3.44836393
107phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.44188735
108vitamin biosynthetic process (GO:0009110)3.43997333
109cGMP biosynthetic process (GO:0006182)3.43881442
110peptide biosynthetic process (GO:0043043)3.41200193
111protein-lipid complex assembly (GO:0065005)3.40364103
112glycerol metabolic process (GO:0006071)3.40104117
113vitamin transport (GO:0051180)3.39015183
114nucleoside diphosphate biosynthetic process (GO:0009133)3.37715390
115carnitine transport (GO:0015879)3.35711751
116amino-acid betaine transport (GO:0015838)3.35711751
117cobalamin metabolic process (GO:0009235)3.34604906
118glyoxylate metabolic process (GO:0046487)3.32768637
119cGMP-mediated signaling (GO:0019934)3.32674858
120alditol metabolic process (GO:0019400)3.28909788
121arginine metabolic process (GO:0006525)3.27200330
122ceramide catabolic process (GO:0046514)3.27064333
123regulation of pseudopodium assembly (GO:0031272)3.27044080
124sterol homeostasis (GO:0055092)3.26936769
125aspartate family amino acid catabolic process (GO:0009068)3.26673325
126sphingomyelin metabolic process (GO:0006684)3.24424053
127beta-amyloid metabolic process (GO:0050435)3.22580901
128sexual reproduction (GO:0019953)3.22310358
129cholesterol homeostasis (GO:0042632)3.21081892
130glycosylceramide metabolic process (GO:0006677)3.20412352
131bile acid metabolic process (GO:0008206)3.19834237
132positive regulation of glycoprotein metabolic process (GO:1903020)3.19786377
133hydrogen peroxide catabolic process (GO:0042744)3.16539533
134sphingolipid catabolic process (GO:0030149)3.16246178
135positive regulation of lipid catabolic process (GO:0050996)3.16103930
136toxin transport (GO:1901998)3.15281221
137L-ascorbic acid metabolic process (GO:0019852)3.14570614
138regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.13194354
139endocrine process (GO:0050886)3.13194354
140regulation of systemic arterial blood pressure by hormone (GO:0001990)3.13194354
141sulfate transport (GO:0008272)3.12181803
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11529050
143positive regulation of cGMP metabolic process (GO:0030825)3.11265173
144renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.11041050
145midgut development (GO:0007494)3.09891015
146cholesterol efflux (GO:0033344)3.08932614
147short-chain fatty acid metabolic process (GO:0046459)3.08875367
148leukotriene metabolic process (GO:0006691)3.07579514
149amino acid transmembrane transport (GO:0003333)3.06314290
150mRNA modification (GO:0016556)3.04604024
151response to hydroperoxide (GO:0033194)3.04120312
152membrane lipid catabolic process (GO:0046466)3.03173068
153glutathione derivative metabolic process (GO:1901685)3.02373393
154glutathione derivative biosynthetic process (GO:1901687)3.02373393
155sodium ion transport (GO:0006814)3.01203862
156regulation of digestive system process (GO:0044058)3.00883494
157cytidine catabolic process (GO:0006216)3.00448902
158cytidine deamination (GO:0009972)3.00448902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.81944336
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.28757410
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.13159935
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.36955683
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.32362195
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.22959915
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.09596695
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.06787944
9SOX2_27498859_Chip-Seq_STOMACH_Mouse2.96218057
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.62940976
11* GATA4_25053715_ChIP-Seq_YYC3_Human2.59355642
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.57466872
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.47056108
14GATA6_25053715_ChIP-Seq_YYC3_Human2.23924340
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.10641915
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.08733809
17SOX2_20726797_ChIP-Seq_SW620_Human2.08560602
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04789738
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92322299
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.85061134
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.79851156
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71691172
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66713955
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63812879
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58571567
26CLOCK_20551151_ChIP-Seq_293T_Human1.56856273
27VDR_22108803_ChIP-Seq_LS180_Human1.56533214
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.55586520
29HNF4A_19822575_ChIP-Seq_HepG2_Human1.46165657
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42981125
31RACK7_27058665_Chip-Seq_MCF-7_Human1.40765635
32BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.39796787
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39259205
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37968912
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37763696
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37733180
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33790866
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.32407373
39* GATA2_19941826_ChIP-Seq_K562_Human1.31478474
40EGR1_19032775_ChIP-ChIP_M12_Human1.28732506
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28682508
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28066648
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.26562029
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.25100520
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24659683
46LXR_22292898_ChIP-Seq_THP-1_Human1.24239299
47SA1_27219007_Chip-Seq_Bcells_Human1.21682110
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.21332532
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19272020
50* BCOR_27268052_Chip-Seq_Bcells_Human1.16133590
51* BCL6_27268052_Chip-Seq_Bcells_Human1.13382659
52* KLF5_25053715_ChIP-Seq_YYC3_Human1.13079797
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12451921
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12288653
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12009842
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.11920539
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07955892
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07481580
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07101060
60ZNF263_19887448_ChIP-Seq_K562_Human1.06839096
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06125322
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05370452
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05278982
64* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04931322
65ATF3_27146783_Chip-Seq_COLON_Human1.03783786
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03572953
67SMAD3_21741376_ChIP-Seq_HESCs_Human1.02844826
68* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02046835
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01420726
70AR_21909140_ChIP-Seq_LNCAP_Human1.00627019
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00025781
72CREB1_26743006_Chip-Seq_LNCaP_Human0.99355312
73RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98707755
74NANOG_20526341_ChIP-Seq_ESCs_Human0.98577125
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98210714
76* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98098589
77ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98051149
78* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93948780
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93306946
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93114088
81DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93059788
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87976735
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87724392
84* TP63_23658742_ChIP-Seq_EP156T_Human0.87721523
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87421381
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86959343
87FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86285359
88CTCF_27219007_Chip-Seq_Bcells_Human0.85224157
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84620874
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84536822
91P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83610412
92GATA1_22025678_ChIP-Seq_K562_Human0.83172436
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83071642
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.82949246
95CEBPB_22108803_ChIP-Seq_LS180_Human0.82927993
96* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82836948
97* VDR_24763502_ChIP-Seq_THP-1_Human0.82297505
98* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82280910
99FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81724491
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81658002
101TP63_22573176_ChIP-Seq_HFKS_Human0.81066703
102STAT1_20625510_ChIP-Seq_HELA_Human0.80183007
103CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80077233
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79869546
105SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79071599
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78870336
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78455112
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77515361
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.77485854
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76187017
111GATA3_24758297_ChIP-Seq_MCF-7_Human0.75986234
112* CDX2_22108803_ChIP-Seq_LS180_Human0.75842737
113MYC_19915707_ChIP-ChIP_AK7_Human0.74791629
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73751327
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72408417
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70750119
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.70566568
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70508967
119CJUN_26792858_Chip-Seq_BT549_Human0.69796274
120EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.69718119
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68560380
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68445926
123TAF2_19829295_ChIP-Seq_ESCs_Human0.67782011
124* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67482346
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67144010
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.67070938
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.67051732
128* GATA1_19941826_ChIP-Seq_K562_Human0.66908723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.62793613
2MP0001666_abnormal_nutrient_absorption4.61953587
3MP0002139_abnormal_hepatobiliary_system4.16899001
4MP0009379_abnormal_foot_pigmentation3.82413965
5MP0004019_abnormal_vitamin_homeostasis3.66206872
6MP0003252_abnormal_bile_duct3.36315443
7MP0003183_abnormal_peptide_metabolism3.19772487
8MP0008875_abnormal_xenobiotic_pharmacok3.08150567
9MP0005332_abnormal_amino_acid3.03252120
10MP0005085_abnormal_gallbladder_physiolo2.88325569
11MP0010234_abnormal_vibrissa_follicle2.80317212
12MP0009643_abnormal_urine_homeostasis2.67812711
13MP0003878_abnormal_ear_physiology2.65888861
14MP0005377_hearing/vestibular/ear_phenot2.65888861
15MP0009840_abnormal_foam_cell2.63071875
16MP0004264_abnormal_extraembryonic_tissu2.62146930
17MP0001765_abnormal_ion_homeostasis2.36132520
18MP0005409_darkened_coat_color2.20554550
19MP0005365_abnormal_bile_salt2.15250963
20MP0000538_abnormal_urinary_bladder2.04739820
21MP0010329_abnormal_lipoprotein_level2.00755793
22MP0005360_urolithiasis10.7070791
23MP0005084_abnormal_gallbladder_morpholo1.97195324
24MP0005636_abnormal_mineral_homeostasis1.93675677
25MP0002136_abnormal_kidney_physiology1.89398448
26MP0004147_increased_porphyrin_level1.88675435
27MP0003866_abnormal_defecation1.78647596
28MP0003868_abnormal_feces_composition1.73516184
29MP0001756_abnormal_urination1.72933233
30MP0000462_abnormal_digestive_system1.71961654
31MP0003195_calcinosis1.66105072
32MP0003300_gastrointestinal_ulcer1.63128334
33MP0002138_abnormal_hepatobiliary_system1.60463361
34MP0005670_abnormal_white_adipose1.56980814
35MP0002876_abnormal_thyroid_physiology1.55706984
36MP0001188_hyperpigmentation1.49015162
37MP0003191_abnormal_cellular_cholesterol1.34422223
38MP0005451_abnormal_body_composition1.30197991
39MP0003718_maternal_effect1.29982826
40MP0002796_impaired_skin_barrier1.28782962
41MP0002089_abnormal_postnatal_growth/wei1.21524216
42MP0001663_abnormal_digestive_system1.20687845
43MP0001664_abnormal_digestion1.15471805
44MP0005381_digestive/alimentary_phenotyp1.15246236
45MP0002822_catalepsy1.10574018
46MP0002118_abnormal_lipid_homeostasis1.06554023
47MP0001501_abnormal_sleep_pattern1.04835875
48MP0008961_abnormal_basal_metabolism1.04403737
49MP0005584_abnormal_enzyme/coenzyme_acti1.04119841
50MP0004782_abnormal_surfactant_physiolog1.02660039
51MP0003283_abnormal_digestive_organ1.02052850
52MP0010155_abnormal_intestine_physiology0.97343989
53MP0003806_abnormal_nucleotide_metabolis0.97169131
54MP0005319_abnormal_enzyme/_coenzyme0.93508745
55MP0005448_abnormal_energy_balance0.93312628
56MP0000609_abnormal_liver_physiology0.92280235
57MP0003705_abnormal_hypodermis_morpholog0.91816159
58MP0000477_abnormal_intestine_morphology0.90447893
59MP0000537_abnormal_urethra_morphology0.90429802
60MP0001958_emphysema0.89259094
61MP0000230_abnormal_systemic_arterial0.87482930
62MP0005501_abnormal_skin_physiology0.86395817
63MP0002254_reproductive_system_inflammat0.84766971
64MP0004885_abnormal_endolymph0.82890859
65MP0001764_abnormal_homeostasis0.82131206
66MP0009780_abnormal_chondrocyte_physiolo0.81553118
67MP0001873_stomach_inflammation0.80923233
68MP0002396_abnormal_hematopoietic_system0.80262550
69MP0005058_abnormal_lysosome_morphology0.79460714
70MP0006054_spinal_hemorrhage0.74573830
71MP0009642_abnormal_blood_homeostasis0.73264709
72MP0002098_abnormal_vibrissa_morphology0.72808559
73MP0003638_abnormal_response/metabolism_0.70451599
74MP0001849_ear_inflammation0.70274596
75MP0003879_abnormal_hair_cell0.69551196
76MP0009697_abnormal_copulation0.68977650
77MP0004947_skin_inflammation0.68255177
78MP0009785_altered_susceptibility_to0.67706529
79MP0010352_gastrointestinal_tract_polyps0.63359186
80MP0004270_analgesia0.61171306
81MP0000490_abnormal_crypts_of0.60632957
82MP0002166_altered_tumor_susceptibility0.59722951
83MP0001485_abnormal_pinna_reflex0.59649028
84MP0005167_abnormal_blood-brain_barrier0.59202536
85MP0005174_abnormal_tail_pigmentation0.59134212
86MP0000678_abnormal_parathyroid_gland0.57762988
87MP0004858_abnormal_nervous_system0.57255810
88MP0002135_abnormal_kidney_morphology0.57072509
89MP0000249_abnormal_blood_vessel0.56974709
90MP0000467_abnormal_esophagus_morphology0.56815160
91MP0005535_abnormal_body_temperature0.55731989
92MP0005334_abnormal_fat_pad0.55207816
93MP0008260_abnormal_autophagy0.54707270
94MP0000465_gastrointestinal_hemorrhage0.54069091
95MP0003724_increased_susceptibility_to0.53903866
96MP0005666_abnormal_adipose_tissue0.53596240
97MP0005025_abnormal_response_to0.53273828
98MP0000015_abnormal_ear_pigmentation0.53085579
99MP0009764_decreased_sensitivity_to0.52705524
100MP0002078_abnormal_glucose_homeostasis0.52367301
101MP0001835_abnormal_antigen_presentation0.52277417
102MP0008872_abnormal_physiological_respon0.51991847
103MP0006138_congestive_heart_failure0.51861596
104MP0003436_decreased_susceptibility_to0.51390290
105MP0009333_abnormal_splenocyte_physiolog0.50331945
106MP0005266_abnormal_metabolism0.50047715
107MP0010678_abnormal_skin_adnexa0.49373971
108MP0001881_abnormal_mammary_gland0.48632980
109MP0002896_abnormal_bone_mineralization0.48501760
110MP0008004_abnormal_stomach_pH0.47951348
111MP0003303_peritoneal_inflammation0.47554736
112MP0005310_abnormal_salivary_gland0.47158890
113MP0005166_decreased_susceptibility_to0.47018711
114MP0003329_amyloid_beta_deposits0.46292043
115MP0006082_CNS_inflammation0.44870691
116MP0001191_abnormal_skin_condition0.44176138
117MP0003953_abnormal_hormone_level0.44142960
118MP0000566_synostosis0.43388050
119MP0009765_abnormal_xenobiotic_induced0.42934408
120MP0001216_abnormal_epidermal_layer0.42533901
121MP0008469_abnormal_protein_level0.42327865
122MP0006036_abnormal_mitochondrial_physio0.40393504
123MP0002971_abnormal_brown_adipose0.40062347
124MP0009115_abnormal_fat_cell0.39176563
125MP0000604_amyloidosis0.38542526
126MP0000377_abnormal_hair_follicle0.37467402
127MP0000598_abnormal_liver_morphology0.37080291
128MP0005376_homeostasis/metabolism_phenot0.36437485
129MP0001845_abnormal_inflammatory_respons0.35628585
130MP0003315_abnormal_perineum_morphology0.33649287

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.25993710
2Hyperactive renin-angiotensin system (HP:0000841)6.12664727
3Metabolic alkalosis (HP:0200114)6.01227167
4* Abnormality of glutamine family amino acid metabolism (HP:0010902)5.73001708
5Hypokalemic alkalosis (HP:0001949)5.65313590
6Abnormality of chloride homeostasis (HP:0011422)5.52967275
7Abnormal urine output (HP:0012590)5.29037046
8Hypomagnesemia (HP:0002917)5.20312169
9Abnormality of renal excretion (HP:0011036)4.97580294
10Abnormality of magnesium homeostasis (HP:0004921)4.96865872
11Gout (HP:0001997)4.96761248
12Polyuria (HP:0000103)4.93000485
13Proximal tubulopathy (HP:0000114)4.61697570
14Malnutrition (HP:0004395)4.51924235
15Ileus (HP:0002595)4.51621080
16Autoimmune thrombocytopenia (HP:0001973)4.47784080
17Abnormality of purine metabolism (HP:0004352)4.41916664
18Abnormality of urine glucose concentration (HP:0011016)4.36093404
19Glycosuria (HP:0003076)4.36093404
20Abnormality of renin-angiotensin system (HP:0000847)4.07364866
21Polydipsia (HP:0001959)3.97933121
22Abnormal drinking behavior (HP:0030082)3.97933121
23Systemic lupus erythematosus (HP:0002725)3.94789953
24Hyperuricemia (HP:0002149)3.90128624
25Increased purine levels (HP:0004368)3.90128624
26Alkalosis (HP:0001948)3.85987757
27Hyperaldosteronism (HP:0000859)3.85677319
28Widely patent fontanelles and sutures (HP:0004492)3.78895280
29Tetany (HP:0001281)3.64943409
30Acanthocytosis (HP:0001927)3.53763260
31Hyperphosphaturia (HP:0003109)3.50299086
32Renal salt wasting (HP:0000127)3.47525186
33Generalized aminoaciduria (HP:0002909)3.41774230
34Hypercalciuria (HP:0002150)3.41240440
35Hypobetalipoproteinemia (HP:0003563)3.41091324
36Dehydration (HP:0001944)3.35565807
37Abnormality of nucleobase metabolism (HP:0010932)3.34625020
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.30653637
39Decreased circulating renin level (HP:0003351)3.22472477
40Abnormal urine phosphate concentration (HP:0012599)3.22002333
41Ketoacidosis (HP:0001993)3.20765759
42Hypokalemia (HP:0002900)3.19850126
43Potter facies (HP:0002009)3.17940529
44Facial shape deformation (HP:0011334)3.17940529
45Conjugated hyperbilirubinemia (HP:0002908)3.16599176
46Steatorrhea (HP:0002570)3.15700641
47Congenital sensorineural hearing impairment (HP:0008527)3.14364610
48Posterior subcapsular cataract (HP:0007787)3.11999922
49* Nephrolithiasis (HP:0000787)3.03222918
50Hyperparathyroidism (HP:0000843)2.91606760
51Hypophosphatemia (HP:0002148)2.83800900
52* Hyperglycinuria (HP:0003108)2.79127007
53Enlarged epiphyses (HP:0010580)2.77866031
54Autoimmune hemolytic anemia (HP:0001890)2.76262795
55Renal tubular acidosis (HP:0001947)2.74821310
56Confusion (HP:0001289)2.74092440
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.72175406
58Delayed epiphyseal ossification (HP:0002663)2.71001626
59Cupped ribs (HP:0000887)2.66550727
60Villous atrophy (HP:0011473)2.61496600
61Abnormality of small intestinal villus morphology (HP:0011472)2.61496600
62Abnormality of potassium homeostasis (HP:0011042)2.61246537
63Focal segmental glomerulosclerosis (HP:0000097)2.60058175
64Metabolic acidosis (HP:0001942)2.60030318
65Chronic diarrhea (HP:0002028)2.56213439
66Eczematoid dermatitis (HP:0000976)2.56170235
67Abnormality of the vitamin B12 metabolism (HP:0004341)2.55751329
68Fat malabsorption (HP:0002630)2.52691329
69Xanthomatosis (HP:0000991)2.48981894
70Hemorrhage of the eye (HP:0011885)2.46482811
71Abnormality of fatty-acid metabolism (HP:0004359)2.45621817
72Abnormality of the costochondral junction (HP:0000919)2.45413469
73Thin bony cortex (HP:0002753)2.44244063
74Ketosis (HP:0001946)2.43215127
75Abnormality of vitamin B metabolism (HP:0004340)2.36530110
76Abdominal distention (HP:0003270)2.35637412
77B lymphocytopenia (HP:0010976)2.34628698
78Abnormality of B cell number (HP:0010975)2.34628698
79Subcapsular cataract (HP:0000523)2.32846200
80Epidermoid cyst (HP:0200040)2.32501522
81Hyperammonemia (HP:0001987)2.32086302
82Increased IgE level (HP:0003212)2.28046552
83Hyperphosphatemia (HP:0002905)2.24243099
84Wide cranial sutures (HP:0010537)2.22290282
85Cerebral palsy (HP:0100021)2.22143273
86Right ventricular cardiomyopathy (HP:0011663)2.21444244
87Vascular calcification (HP:0004934)2.20954381
88Pigmentary retinal degeneration (HP:0001146)2.20469305
89Protuberant abdomen (HP:0001538)2.20149199
90Rickets (HP:0002748)2.19797561
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.19593404
92* Abnormality of glycine metabolism (HP:0010895)2.17638907
93* Abnormality of serine family amino acid metabolism (HP:0010894)2.17638907
94Gastrointestinal dysmotility (HP:0002579)2.17269777
95Abnormal tarsal ossification (HP:0008369)2.15300061
96Severe combined immunodeficiency (HP:0004430)2.13170838
97Metaphyseal cupping (HP:0003021)2.12835395
98Pancreatitis (HP:0001733)2.10653051
99Nausea (HP:0002018)2.10440269
100Vacuolated lymphocytes (HP:0001922)2.07314828
101Adrenal overactivity (HP:0002717)2.06773068
102Hypotension (HP:0002615)2.05168494
103Mesangial abnormality (HP:0001966)2.04852072
104Nephrocalcinosis (HP:0000121)2.02751859
105Irritability (HP:0000737)2.00651221
106Multiple lipomas (HP:0001012)2.00469190
107Dicarboxylic aciduria (HP:0003215)1.99758481
108Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99758481
109Vomiting (HP:0002013)1.98426844
110Poikilocytosis (HP:0004447)1.96373011
111Renal tubular dysfunction (HP:0000124)1.96077499
112Growth hormone excess (HP:0000845)1.94459453
113Hypolipoproteinemia (HP:0010981)1.93829856
114Abnormal glucose tolerance (HP:0001952)1.93627897
115Cardiovascular calcification (HP:0011915)1.93529251
116Abnormality of sodium homeostasis (HP:0010931)1.92073012
117Glomerulosclerosis (HP:0000096)1.91885083
118Hyponatremia (HP:0002902)1.91056552
119Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91051777
120Paresthesia (HP:0003401)1.91040026
121Abnormality of alkaline phosphatase activity (HP:0004379)1.90425782
122Combined immunodeficiency (HP:0005387)1.90234109
123Bilateral sensorineural hearing impairment (HP:0008619)1.89476358
124Abnormality of pyrimidine metabolism (HP:0004353)1.87654010
125Hypocalcemia (HP:0002901)1.86250985
126Thyroiditis (HP:0100646)1.85235253
127Glomerulonephritis (HP:0000099)1.85136870
128Abnormal enzyme/coenzyme activity (HP:0012379)1.85000512
129* Hydroxyprolinuria (HP:0003080)1.83345774
130* Abnormality of proline metabolism (HP:0010907)1.83345774
131Megaloblastic anemia (HP:0001889)1.83229379
132Late onset (HP:0003584)1.82058458
133Abnormality of vitamin metabolism (HP:0100508)1.81850331
134Abnormality of complement system (HP:0005339)1.81417730
135Hypoalbuminemia (HP:0003073)1.80416975
136Abnormal albumin level (HP:0012116)1.80416975
137Segmental peripheral demyelination/remyelination (HP:0003481)1.80028705
138White forelock (HP:0002211)1.79933442
139Patchy hypopigmentation of hair (HP:0011365)1.75546276
140Symptomatic seizures (HP:0011145)1.73760344
141Complement deficiency (HP:0004431)1.71984451
142Nephritis (HP:0000123)1.70454612
143Lethargy (HP:0001254)1.68359733
144Metaphyseal irregularity (HP:0003025)1.68333986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.41559626
2WNK46.17255062
3WNK35.35634786
4OXSR15.10994079
5MST45.00983726
6FRK4.63545561
7MST1R3.36193168
8GRK63.06962381
9STK393.01170878
10LMTK22.41913127
11NME12.19948852
12MAP3K21.92105109
13AKT31.89097181
14PRKG21.86291059
15PTK61.79089038
16MAP3K101.70384171
17ERN11.67475397
18RIPK11.62334389
19EPHA31.55006070
20PRPF4B1.48283868
21MAP2K21.41620906
22TNIK1.40287661
23EPHA21.32489238
24STK101.29700142
25MAP3K121.24388998
26EPHA41.21862775
27PDK21.18485726
28EPHB11.15185474
29PDK31.15111150
30PDK41.15111150
31MAP3K71.12998117
32MET1.08451153
33STK38L1.06538842
34WNK11.03856176
35PTK21.03235867
36FGFR30.99311527
37NUAK10.96774688
38PRKCI0.96607916
39BCKDK0.96095769
40LRRK20.95286209
41STK240.95252298
42SGK4940.90202392
43SGK2230.90202392
44MAP3K30.87401187
45FGFR40.86984306
46EPHB20.85548909
47NLK0.83050752
48CDC42BPA0.80309776
49TESK20.80031363
50FER0.79524249
51TAOK10.78872078
52NEK10.76980623
53LATS10.75905594
54INSRR0.73032570
55SGK30.72579420
56TESK10.71913134
57PRKAA20.70830666
58PIK3CA0.69884396
59DYRK1B0.67317092
60ITK0.64494916
61MAPK110.63162573
62BMX0.58113849
63PDPK10.57526722
64PAK40.56372987
65KSR20.56142139
66BMPR20.55127456
67MAP4K10.54487742
68PRKAA10.53499938
69GSK3A0.52955221
70IRAK10.52262482
71MAP3K110.50590322
72RIPK40.49355522
73MAP2K60.47925616
74MATK0.47476314
75STK380.47442896
76RET0.45140828
77JAK10.44199813
78SCYL20.44193959
79PAK30.44096495
80ERBB20.43471644
81MAP3K80.43384511
82TAOK30.42658718
83MYLK0.42086257
84DAPK20.41520977
85PDK10.41398899
86YES10.41264091
87TBK10.40216847
88MAP3K10.39577324
89CSF1R0.37931847
90SGK20.37891185
91CAMK2D0.36965364
92CASK0.36842331
93MAP2K10.36314386
94IKBKE0.35543136
95CSK0.34335830
96TYK20.34197235
97CDK60.34152786
98DDR20.33650863
99ABL20.32798316
100BTK0.32690555
101MELK0.31093757
102IRAK30.30713584
103CAMK2G0.30586687
104ZAP700.29968203
105TRIB30.29795217
106MAPK150.29622226
107SYK0.29602529
108CAMK2B0.28613186
109NEK60.28501471
110SMG10.27669019
111PRKCD0.26595134
112PRKACG0.26572124
113PRKCA0.26259108
114TEC0.25654516
115PRKCQ0.24528778
116SRC0.23143088
117TTK0.21596010
118LYN0.21344175
119RPS6KA20.20948930
120CDK190.20364160
121STK110.19646052
122JAK20.19482618
123ICK0.18864705
124JAK30.18467792
125MAPKAPK20.18098402
126LCK0.17352978
127PIM20.15785360
128GRK10.15684238
129PRKD20.15103753
130MAP3K140.15069976
131CSNK1A10.14974827
132SGK10.14854030
133FYN0.14248535
134PRKCZ0.13663412
135NTRK10.11918399
136INSR0.11419580
137PDGFRA0.11302191
138ROCK10.10471224
139PIM10.09671622
140ERBB40.08830584

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.23899536
2Vitamin digestion and absorption_Homo sapiens_hsa049774.02534572
3Renin-angiotensin system_Homo sapiens_hsa046143.90836405
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.22038072
5* Mineral absorption_Homo sapiens_hsa049783.05256498
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.91694094
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.69166832
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.48891438
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.47633004
10Bile secretion_Homo sapiens_hsa049762.33942081
11Starch and sucrose metabolism_Homo sapiens_hsa005002.33735404
12* Protein digestion and absorption_Homo sapiens_hsa049742.18498178
13Sulfur metabolism_Homo sapiens_hsa009202.17515350
14Folate biosynthesis_Homo sapiens_hsa007902.00488034
15Galactose metabolism_Homo sapiens_hsa000521.97871836
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92262098
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87519453
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86023688
19Caffeine metabolism_Homo sapiens_hsa002321.85875333
20Butanoate metabolism_Homo sapiens_hsa006501.84625096
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.84278934
22Tryptophan metabolism_Homo sapiens_hsa003801.84027972
23Fatty acid degradation_Homo sapiens_hsa000711.67927010
24Glutathione metabolism_Homo sapiens_hsa004801.64814447
25Fructose and mannose metabolism_Homo sapiens_hsa000511.59608342
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59250371
27PPAR signaling pathway_Homo sapiens_hsa033201.59126247
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59105755
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57645304
30Histidine metabolism_Homo sapiens_hsa003401.55004242
31Pyruvate metabolism_Homo sapiens_hsa006201.47954352
32Propanoate metabolism_Homo sapiens_hsa006401.39952350
33Glycerolipid metabolism_Homo sapiens_hsa005611.39038943
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34717785
35Peroxisome_Homo sapiens_hsa041461.33398828
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30925075
37Arginine and proline metabolism_Homo sapiens_hsa003301.20876595
38Arginine biosynthesis_Homo sapiens_hsa002201.16161956
39beta-Alanine metabolism_Homo sapiens_hsa004101.14798488
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14651613
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12622288
42Carbon metabolism_Homo sapiens_hsa012001.10931934
43Sphingolipid metabolism_Homo sapiens_hsa006001.10835811
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06122686
45Collecting duct acid secretion_Homo sapiens_hsa049661.01404477
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01332567
47Asthma_Homo sapiens_hsa053100.98656744
48Fatty acid metabolism_Homo sapiens_hsa012120.95210326
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90139748
50Thyroid hormone synthesis_Homo sapiens_hsa049180.86796431
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85453557
52ABC transporters_Homo sapiens_hsa020100.84272917
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74558886
54Lysine degradation_Homo sapiens_hsa003100.73245094
55Allograft rejection_Homo sapiens_hsa053300.71388381
56Nitrogen metabolism_Homo sapiens_hsa009100.70743119
57Autoimmune thyroid disease_Homo sapiens_hsa053200.66933986
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65915755
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65364116
60Graft-versus-host disease_Homo sapiens_hsa053320.62338495
61Pentose phosphate pathway_Homo sapiens_hsa000300.60905306
62Other glycan degradation_Homo sapiens_hsa005110.58743177
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.58534716
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57943150
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54363923
66Staphylococcus aureus infection_Homo sapiens_hsa051500.53248380
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53147705
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51314731
69Biosynthesis of amino acids_Homo sapiens_hsa012300.51127491
70Selenocompound metabolism_Homo sapiens_hsa004500.50300188
71Phenylalanine metabolism_Homo sapiens_hsa003600.50141567
72Arachidonic acid metabolism_Homo sapiens_hsa005900.48612430
73Gastric acid secretion_Homo sapiens_hsa049710.47585346
74Type I diabetes mellitus_Homo sapiens_hsa049400.45439406
75Chemical carcinogenesis_Homo sapiens_hsa052040.45267485
76Retinol metabolism_Homo sapiens_hsa008300.43290148
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41537595
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.40929720
79Fatty acid biosynthesis_Homo sapiens_hsa000610.39348924
80Renin secretion_Homo sapiens_hsa049240.39100973
81Metabolic pathways_Homo sapiens_hsa011000.38318696
82Tyrosine metabolism_Homo sapiens_hsa003500.36353337
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.34182248
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32677700
85Pancreatic secretion_Homo sapiens_hsa049720.28950005
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28495312
87Antigen processing and presentation_Homo sapiens_hsa046120.28174876
88Cocaine addiction_Homo sapiens_hsa050300.26762427
89Fatty acid elongation_Homo sapiens_hsa000620.26363097
90Sulfur relay system_Homo sapiens_hsa041220.24618795
91Glucagon signaling pathway_Homo sapiens_hsa049220.22743101
92Tight junction_Homo sapiens_hsa045300.22349630
93Vibrio cholerae infection_Homo sapiens_hsa051100.22294825
94Leishmaniasis_Homo sapiens_hsa051400.21789974
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21484611
96Type II diabetes mellitus_Homo sapiens_hsa049300.21480604
97Steroid biosynthesis_Homo sapiens_hsa001000.20697189
98Choline metabolism in cancer_Homo sapiens_hsa052310.19906545
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.18209830
100Hepatitis C_Homo sapiens_hsa051600.16642537
101Insulin resistance_Homo sapiens_hsa049310.16114815
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.15632544
103Linoleic acid metabolism_Homo sapiens_hsa005910.15479575
104Bladder cancer_Homo sapiens_hsa052190.15331233
105Inositol phosphate metabolism_Homo sapiens_hsa005620.14352015
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11348634
107Amphetamine addiction_Homo sapiens_hsa050310.10107635
108Hematopoietic cell lineage_Homo sapiens_hsa046400.08687900
109Lysosome_Homo sapiens_hsa041420.07317153
110Insulin secretion_Homo sapiens_hsa049110.06908860
111AMPK signaling pathway_Homo sapiens_hsa041520.06902812
112Viral myocarditis_Homo sapiens_hsa054160.05678997
113Serotonergic synapse_Homo sapiens_hsa047260.05583276
114Pertussis_Homo sapiens_hsa051330.05487814
115African trypanosomiasis_Homo sapiens_hsa051430.04760469
116Toxoplasmosis_Homo sapiens_hsa051450.04170124
117GnRH signaling pathway_Homo sapiens_hsa049120.04021291
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03626916
119Oxidative phosphorylation_Homo sapiens_hsa001900.03227791
120Ether lipid metabolism_Homo sapiens_hsa005650.03221481
121Primary immunodeficiency_Homo sapiens_hsa053400.02351027
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.01737193
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.01099908
124Thyroid cancer_Homo sapiens_hsa052160.00527195
125Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0230631
126Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0212339
127Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0169948
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0002885

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