SLC6A20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)5.95444864
2regulation of guanylate cyclase activity (GO:0031282)5.67818068
3epoxygenase P450 pathway (GO:0019373)4.81730786
4positive regulation of guanylate cyclase activity (GO:0031284)4.59721300
5intestinal absorption (GO:0050892)4.33407185
6drug catabolic process (GO:0042737)4.33406427
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.28210839
8fucose catabolic process (GO:0019317)4.24137581
9L-fucose metabolic process (GO:0042354)4.24137581
10L-fucose catabolic process (GO:0042355)4.24137581
11fat-soluble vitamin biosynthetic process (GO:0042362)4.19428250
12flavonoid metabolic process (GO:0009812)4.08933484
13drug metabolic process (GO:0017144)4.05287093
14exogenous drug catabolic process (GO:0042738)3.95184111
15alkaloid metabolic process (GO:0009820)3.93742096
16regulation of triglyceride catabolic process (GO:0010896)3.88777340
17regulation of bile acid biosynthetic process (GO:0070857)3.73171139
18regulation of cGMP biosynthetic process (GO:0030826)3.72839152
19sulfation (GO:0051923)3.71549699
20indolalkylamine metabolic process (GO:0006586)3.69400413
21vitamin A metabolic process (GO:0006776)3.66549512
22transepithelial transport (GO:0070633)3.65585251
23cellular glucuronidation (GO:0052695)3.65253515
24uronic acid metabolic process (GO:0006063)3.60534241
25glucuronate metabolic process (GO:0019585)3.60534241
26bile acid and bile salt transport (GO:0015721)3.59093723
27digestion (GO:0007586)3.58028109
28photoreceptor cell maintenance (GO:0045494)3.48269393
29vitamin transmembrane transport (GO:0035461)3.44617853
30lipoprotein transport (GO:0042953)3.43769815
31piRNA metabolic process (GO:0034587)3.43627025
32quinone biosynthetic process (GO:1901663)3.42939411
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.38828075
34tryptophan catabolic process (GO:0006569)3.26765007
35indole-containing compound catabolic process (GO:0042436)3.26765007
36indolalkylamine catabolic process (GO:0046218)3.26765007
37arginine metabolic process (GO:0006525)3.20231767
38regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.17141919
39endocrine process (GO:0050886)3.17141919
40regulation of systemic arterial blood pressure by hormone (GO:0001990)3.17141919
41glycerol metabolic process (GO:0006071)3.16424000
42detection of light stimulus involved in sensory perception (GO:0050962)3.15760305
43detection of light stimulus involved in visual perception (GO:0050908)3.15760305
44vitamin biosynthetic process (GO:0009110)3.15073380
45regulation of cGMP metabolic process (GO:0030823)3.14894583
46regulation of protein glycosylation (GO:0060049)3.14014369
47cellular ketone body metabolic process (GO:0046950)3.09368167
48receptor guanylyl cyclase signaling pathway (GO:0007168)3.08009379
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06310039
50vitamin transport (GO:0051180)3.02909984
51fat-soluble vitamin metabolic process (GO:0006775)3.02657621
52sulfate transmembrane transport (GO:1902358)3.01059794
533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.00168151
54purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.00168151
55peptide hormone processing (GO:0016486)2.99666767
56oxidative demethylation (GO:0070989)2.99268847
57sulfur compound transport (GO:0072348)2.98050771
58positive regulation of cGMP biosynthetic process (GO:0030828)2.95947854
59regulation of systemic arterial blood pressure (GO:0003073)2.95946781
60regulation of pigment cell differentiation (GO:0050932)2.95000092
61drug transmembrane transport (GO:0006855)2.92677424
62heme transport (GO:0015886)2.92256563
63cilium or flagellum-dependent cell motility (GO:0001539)2.90919462
64ketone body metabolic process (GO:1902224)2.89598562
65positive regulation of glycoprotein biosynthetic process (GO:0010560)2.88636744
66tryptophan metabolic process (GO:0006568)2.87770526
67kidney morphogenesis (GO:0060993)2.85310291
68bile acid metabolic process (GO:0008206)2.84248560
69behavioral response to nicotine (GO:0035095)2.83001658
70urate metabolic process (GO:0046415)2.82508789
71hormone catabolic process (GO:0042447)2.82160604
72auditory receptor cell differentiation (GO:0042491)2.80034172
73L-ascorbic acid metabolic process (GO:0019852)2.78672083
74regulation of cellular extravasation (GO:0002691)2.77720357
75cytidine deamination (GO:0009972)2.76023681
76cytidine metabolic process (GO:0046087)2.76023681
77cytidine catabolic process (GO:0006216)2.76023681
78behavioral response to ethanol (GO:0048149)2.75110592
79phosphatidylinositol acyl-chain remodeling (GO:0036149)2.72626921
80alditol metabolic process (GO:0019400)2.71704176
81cobalamin metabolic process (GO:0009235)2.70718346
82sulfate transport (GO:0008272)2.66038081
83drug transport (GO:0015893)2.65171595
84homocysteine metabolic process (GO:0050667)2.64991763
85fucosylation (GO:0036065)2.64343652
86regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.63871354
87auditory receptor cell stereocilium organization (GO:0060088)2.63279344
88phosphatidylserine acyl-chain remodeling (GO:0036150)2.62885675
89positive regulation of fatty acid transport (GO:2000193)2.62728611
90positive regulation of oligodendrocyte differentiation (GO:0048714)2.61473340
91cGMP biosynthetic process (GO:0006182)2.61013883
92neural tube formation (GO:0001841)2.59806959
93kynurenine metabolic process (GO:0070189)2.59460205
94thyroid hormone metabolic process (GO:0042403)2.58545739
95positive regulation of icosanoid secretion (GO:0032305)2.54254436
96thrombin receptor signaling pathway (GO:0070493)2.53940562
97protein K11-linked deubiquitination (GO:0035871)2.51207146
98DNA methylation involved in gamete generation (GO:0043046)2.51117313
99maintenance of gastrointestinal epithelium (GO:0030277)2.50521479
100response to nitrosative stress (GO:0051409)2.50384656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.38353833
2ZNF274_21170338_ChIP-Seq_K562_Hela3.14174054
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65869705
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62126496
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47607822
6IGF1R_20145208_ChIP-Seq_DFB_Human2.38858497
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34824722
8GBX2_23144817_ChIP-Seq_PC3_Human2.34403794
9AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09990492
10P300_19829295_ChIP-Seq_ESCs_Human2.01105081
11EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95599923
12FLI1_27457419_Chip-Seq_LIVER_Mouse1.91002906
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85415586
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84337098
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82646045
16* BCAT_22108803_ChIP-Seq_LS180_Human1.79951283
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78178956
18FUS_26573619_Chip-Seq_HEK293_Human1.76906567
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70966784
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70570646
21ER_23166858_ChIP-Seq_MCF-7_Human1.69657800
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.68871177
23NR3C1_21868756_ChIP-Seq_MCF10A_Human1.67426835
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66453225
25STAT3_23295773_ChIP-Seq_U87_Human1.65890273
26EWS_26573619_Chip-Seq_HEK293_Human1.65502764
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.65290520
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63257474
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61673438
30CBP_20019798_ChIP-Seq_JUKART_Human1.61673438
31EZH2_22144423_ChIP-Seq_EOC_Human1.58947423
32TAF15_26573619_Chip-Seq_HEK293_Human1.58940756
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58590170
34* CDX2_22108803_ChIP-Seq_LS180_Human1.58545926
35* TCF4_22108803_ChIP-Seq_LS180_Human1.57174006
36TCF4_23295773_ChIP-Seq_U87_Human1.54898290
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.54690392
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54429764
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.54337252
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53889392
41* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.53163305
42SMAD4_21799915_ChIP-Seq_A2780_Human1.52089930
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50289461
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49803777
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.48858050
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48193573
47GATA4_25053715_ChIP-Seq_YYC3_Human1.45231888
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43627295
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43602663
50AR_25329375_ChIP-Seq_VCAP_Human1.40878562
51* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40108208
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37132241
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.36748776
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36141459
55* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35755648
56* FOXA1_25329375_ChIP-Seq_VCAP_Human1.35755648
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35519537
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34279480
59NANOG_19829295_ChIP-Seq_ESCs_Human1.34145923
60SOX2_19829295_ChIP-Seq_ESCs_Human1.34145923
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32230152
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28463822
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.27997291
64AR_20517297_ChIP-Seq_VCAP_Human1.25813995
65IRF1_19129219_ChIP-ChIP_H3396_Human1.25413613
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24367437
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23812084
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23812084
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23586733
70RXR_22108803_ChIP-Seq_LS180_Human1.22312798
71RUNX2_22187159_ChIP-Seq_PCA_Human1.21385307
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18926186
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17473641
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.17460854
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.16456163
76* NCOR_22424771_ChIP-Seq_293T_Human1.14774927
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14440176
78TP53_22573176_ChIP-Seq_HFKS_Human1.14357940
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.13204763
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11828718
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.11223950
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09073554
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08041893
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07931294
85TP53_16413492_ChIP-PET_HCT116_Human1.07915810
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07656720
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.07052010
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06473237
89KDM2B_26808549_Chip-Seq_REH_Human1.05633839
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.05521754
91HOXB7_26014856_ChIP-Seq_BT474_Human1.05254987
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05132746
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.04713214
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03354625
95AHR_22903824_ChIP-Seq_MCF-7_Human1.02736880
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02320418
97* SMAD3_21741376_ChIP-Seq_HESCs_Human1.01208131
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00785149
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00576352
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00328654

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.55758228
2MP0005085_abnormal_gallbladder_physiolo4.03246015
3MP0003183_abnormal_peptide_metabolism3.84288747
4MP0001666_abnormal_nutrient_absorption3.54858620
5MP0004147_increased_porphyrin_level3.29950634
6MP0005365_abnormal_bile_salt3.11177907
7MP0004019_abnormal_vitamin_homeostasis3.07856297
8MP0002139_abnormal_hepatobiliary_system2.89161487
9MP0003195_calcinosis2.52502029
10MP0001501_abnormal_sleep_pattern2.31827558
11MP0003718_maternal_effect2.20444426
12MP0005551_abnormal_eye_electrophysiolog2.15954235
13MP0002876_abnormal_thyroid_physiology2.13461888
14MP0003011_delayed_dark_adaptation2.07627036
15MP0001664_abnormal_digestion2.00534247
16MP0000569_abnormal_digit_pigmentation1.96424004
17MP0005174_abnormal_tail_pigmentation1.94510145
18MP0010329_abnormal_lipoprotein_level1.93997341
19MP0005332_abnormal_amino_acid1.86310770
20MP0004043_abnormal_pH_regulation1.82684560
21MP0003252_abnormal_bile_duct1.82305464
22MP0001764_abnormal_homeostasis1.77032147
23MP0008872_abnormal_physiological_respon1.65746348
24MP0008877_abnormal_DNA_methylation1.64653496
25MP0004264_abnormal_extraembryonic_tissu1.62658914
26MP0001986_abnormal_taste_sensitivity1.61636402
27MP0002102_abnormal_ear_morphology1.58934750
28MP0000538_abnormal_urinary_bladder1.54491878
29MP0001485_abnormal_pinna_reflex1.53785913
30MP0000427_abnormal_hair_cycle1.53084684
31MP0002138_abnormal_hepatobiliary_system1.43733332
32MP0009840_abnormal_foam_cell1.43483237
33MP0009643_abnormal_urine_homeostasis1.39031422
34MP0008875_abnormal_xenobiotic_pharmacok1.38607151
35MP0010155_abnormal_intestine_physiology1.38442165
36MP0001968_abnormal_touch/_nociception1.36127899
37MP0003868_abnormal_feces_composition1.28986045
38MP0005253_abnormal_eye_physiology1.28752489
39MP0000015_abnormal_ear_pigmentation1.26972981
40MP0000230_abnormal_systemic_arterial1.26174952
41MP0001765_abnormal_ion_homeostasis1.25735913
42MP0005645_abnormal_hypothalamus_physiol1.16861718
43MP0005636_abnormal_mineral_homeostasis1.13038614
44MP0003866_abnormal_defecation1.12998870
45MP0006072_abnormal_retinal_apoptosis1.12212127
46MP0001756_abnormal_urination1.11507111
47MP0005670_abnormal_white_adipose1.10900649
48MP0005448_abnormal_energy_balance1.09389936
49MP0005395_other_phenotype1.09022200
50MP0002736_abnormal_nociception_after1.08874819
51MP0008057_abnormal_DNA_replication1.05199482
52MP0006054_spinal_hemorrhage1.05128095
53MP0003787_abnormal_imprinting1.04905428
54MP0000383_abnormal_hair_follicle1.02341092
55MP0003646_muscle_fatigue1.01913640
56MP0010234_abnormal_vibrissa_follicle0.98119339
57MP0003879_abnormal_hair_cell0.97425724
58MP0002136_abnormal_kidney_physiology0.95531894
59MP0002118_abnormal_lipid_homeostasis0.95233448
60MP0002735_abnormal_chemical_nociception0.95018746
61MP0001324_abnormal_eye_pigmentation0.92269734
62MP0010678_abnormal_skin_adnexa0.92130390
63MP0003045_fibrosis0.91480198
64MP0008789_abnormal_olfactory_epithelium0.87354012
65MP0003136_yellow_coat_color0.86462124
66MP0002272_abnormal_nervous_system0.84268068
67MP0000372_irregular_coat_pigmentation0.80325199
68MP0009764_decreased_sensitivity_to0.80026837
69MP0002277_abnormal_respiratory_mucosa0.79468400
70MP0002733_abnormal_thermal_nociception0.78171704
71MP0009780_abnormal_chondrocyte_physiolo0.77480283
72MP0001486_abnormal_startle_reflex0.76869357
73MP0005386_behavior/neurological_phenoty0.76771190
74MP0004924_abnormal_behavior0.76771190
75MP0003890_abnormal_embryonic-extraembry0.76063183
76MP0008775_abnormal_heart_ventricle0.75559695
77MP0002928_abnormal_bile_duct0.73676694
78MP0002822_catalepsy0.71870904
79MP0003880_abnormal_central_pattern0.70460545
80MP0006276_abnormal_autonomic_nervous0.70147138
81MP0002229_neurodegeneration0.69918583
82MP0004270_analgesia0.68603736
83MP0005535_abnormal_body_temperature0.68200516
84MP0002098_abnormal_vibrissa_morphology0.67443199
85MP0009745_abnormal_behavioral_response0.67405511
86MP0003724_increased_susceptibility_to0.66508945
87MP0004885_abnormal_endolymph0.65556066
88MP0005195_abnormal_posterior_eye0.65096888
89MP0005075_abnormal_melanosome_morpholog0.64557145
90MP0002095_abnormal_skin_pigmentation0.64385000
91MP0002938_white_spotting0.63921854
92MP0001970_abnormal_pain_threshold0.63736216
93MP0001873_stomach_inflammation0.61208509
94MP0003806_abnormal_nucleotide_metabolis0.60945978
95MP0000470_abnormal_stomach_morphology0.60692843
96MP0005410_abnormal_fertilization0.60618319
97MP0005377_hearing/vestibular/ear_phenot0.60616247
98MP0003878_abnormal_ear_physiology0.60616247
99MP0003953_abnormal_hormone_level0.60240187
100MP0004215_abnormal_myocardial_fiber0.60222261

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of glutamine family amino acid metabolism (HP:0010902)5.36667678
2Abnormality of the vitamin B12 metabolism (HP:0004341)4.17088932
3Abnormality of vitamin B metabolism (HP:0004340)4.15385930
4Chronic diarrhea (HP:0002028)3.73125323
5Congenital sensorineural hearing impairment (HP:0008527)3.65055686
6Pancreatic cysts (HP:0001737)3.50955451
7Hyperventilation (HP:0002883)3.48308258
8Congenital stationary night blindness (HP:0007642)3.43923945
9Decreased circulating renin level (HP:0003351)3.39240049
10Malnutrition (HP:0004395)3.37040869
11Pigmentary retinal degeneration (HP:0001146)3.36420864
12Confusion (HP:0001289)3.21300998
13True hermaphroditism (HP:0010459)3.15674269
14* Abnormality of proline metabolism (HP:0010907)3.15241702
15* Hydroxyprolinuria (HP:0003080)3.15241702
16Pancreatic fibrosis (HP:0100732)3.11512919
17Attenuation of retinal blood vessels (HP:0007843)3.11441178
18Abnormality of vitamin metabolism (HP:0100508)3.10345051
19Decreased central vision (HP:0007663)2.97245124
20Hypobetalipoproteinemia (HP:0003563)2.94991661
21Abnormality of midbrain morphology (HP:0002418)2.92782553
22Molar tooth sign on MRI (HP:0002419)2.92782553
23Abnormality of the renal cortex (HP:0011035)2.86016744
24Abnormality of urine glucose concentration (HP:0011016)2.80885334
25Glycosuria (HP:0003076)2.80885334
26* Hyperglycinuria (HP:0003108)2.78018711
27Fat malabsorption (HP:0002630)2.76322861
28Ileus (HP:0002595)2.70737575
29Abolished electroretinogram (ERG) (HP:0000550)2.70695294
30Bony spicule pigmentary retinopathy (HP:0007737)2.68241382
31Methylmalonic aciduria (HP:0012120)2.63535969
32Widely patent fontanelles and sutures (HP:0004492)2.63412416
33Abnormality of macular pigmentation (HP:0008002)2.60643952
34Proximal tubulopathy (HP:0000114)2.59455605
35* Abnormality of serine family amino acid metabolism (HP:0010894)2.58673630
36* Abnormality of glycine metabolism (HP:0010895)2.58673630
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.53596261
38Cystic liver disease (HP:0006706)2.51747486
39Abnormal rod and cone electroretinograms (HP:0008323)2.44789017
40Renal cortical cysts (HP:0000803)2.38000618
41Pendular nystagmus (HP:0012043)2.36799588
42Gaze-evoked nystagmus (HP:0000640)2.34768447
43Stomach cancer (HP:0012126)2.33828302
44Nephronophthisis (HP:0000090)2.33777642
45Chronic hepatic failure (HP:0100626)2.32994630
46Medial flaring of the eyebrow (HP:0010747)2.32348284
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32289626
48Acanthocytosis (HP:0001927)2.31228036
49Chorioretinal atrophy (HP:0000533)2.28790881
50Abnormality of renin-angiotensin system (HP:0000847)2.27049653
51Increased corneal curvature (HP:0100692)2.24014472
52Keratoconus (HP:0000563)2.24014472
53Abnormality of the renal medulla (HP:0100957)2.23101229
54Scotoma (HP:0000575)2.20677138
55Potter facies (HP:0002009)2.18659671
56Facial shape deformation (HP:0011334)2.18659671
57Choroideremia (HP:0001139)2.18254833
58Absent/shortened dynein arms (HP:0200106)2.14246500
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.14246500
60Tubular atrophy (HP:0000092)2.13309729
61Metabolic alkalosis (HP:0200114)2.12600928
62Hypothermia (HP:0002045)2.12560343
63Steatorrhea (HP:0002570)2.08937342
64Posterior subcapsular cataract (HP:0007787)2.07121766
65Thyroiditis (HP:0100646)2.06157701
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.04970150
67Alkalosis (HP:0001948)2.03699351
68Hyperglycinemia (HP:0002154)2.02857630
69Abnormality of the fovea (HP:0000493)2.01221498
70Hyperactive renin-angiotensin system (HP:0000841)1.96269500
71Central scotoma (HP:0000603)1.96158220
72Nausea (HP:0002018)1.95833850
73Bile duct proliferation (HP:0001408)1.94088568
74Abnormal biliary tract physiology (HP:0012439)1.94088568
75Abnormal albumin level (HP:0012116)1.92643194
76Hypoalbuminemia (HP:0003073)1.92643194
77Metabolic acidosis (HP:0001942)1.91369683
78Methylmalonic acidemia (HP:0002912)1.91194644
79Febrile seizures (HP:0002373)1.91157403
80Congenital hepatic fibrosis (HP:0002612)1.90860294
81Clumsiness (HP:0002312)1.90742517
82Ketosis (HP:0001946)1.90376716
83Epidermoid cyst (HP:0200040)1.89010364
84Hypoplasia of the fovea (HP:0007750)1.85217531
85Aplasia/Hypoplasia of the fovea (HP:0008060)1.85217531
86Macular degeneration (HP:0000608)1.84238495
87Intestinal atresia (HP:0011100)1.83303909
88Retinitis pigmentosa (HP:0000510)1.83297408
89Abnormal biliary tract morphology (HP:0012440)1.82951193
90Congenital primary aphakia (HP:0007707)1.81326257
91Abnormal pancreas size (HP:0012094)1.80550880
92Furrowed tongue (HP:0000221)1.80155792
93Gait imbalance (HP:0002141)1.78994288
94Lethargy (HP:0001254)1.78375638
95Tubulointerstitial nephritis (HP:0001970)1.77487210
96Absent speech (HP:0001344)1.76139087
97Constricted visual fields (HP:0001133)1.75674592
98Nephrogenic diabetes insipidus (HP:0009806)1.74871268
99Broad-based gait (HP:0002136)1.72874380
100Volvulus (HP:0002580)1.71585747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.58209967
2ACVR1B6.29191608
3BMPR1B3.14643563
4GRK12.70854167
5STK392.62974826
6ADRBK22.45648521
7CASK2.29914940
8MAP4K22.13381736
9OXSR11.97225411
10NUAK11.93895349
11TNIK1.93616717
12MST41.81650325
13MST1R1.79020897
14EPHA41.76112131
15TAOK31.73041364
16WNK31.69855517
17ZAK1.55464415
18PINK11.52118790
19IRAK11.48614134
20EPHA31.47335343
21WNK41.45110168
22AKT31.44090850
23STK38L1.31775846
24MAPK131.27227355
25BRSK21.26778999
26NLK1.20033850
27PIK3CG1.18751860
28INSRR1.11688685
29TXK1.11060501
30MAP3K91.09820678
31PRKG21.09611726
32CAMKK21.07786988
33MAP3K41.06962076
34DAPK21.04358607
35FER1.04211607
36MARK11.04143828
37MET1.02065662
38TRIM280.99985083
39PRKCE0.96499402
40MKNK20.95549449
41PAK30.93470761
42TGFBR10.87078815
43PRKAA20.84613017
44ADRBK10.83566636
45TEC0.82008426
46PDK20.80799577
47LMTK20.78716554
48TLK10.74261093
49EIF2AK30.74039022
50EPHA20.73485303
51BCKDK0.62997780
52KIT0.60373599
53GRK60.59863795
54MUSK0.58961158
55PIK3CA0.58450083
56TAF10.58169891
57TIE10.55413969
58PTK2B0.55133233
59BCR0.54814697
60ERBB20.50938586
61PRKCQ0.50378765
62STK30.49890772
63MAP4K10.49210333
64MATK0.48531996
65NTRK30.48107217
66PRKCI0.47700141
67ITK0.47488971
68PRKCZ0.47220782
69CSNK1G20.46557373
70PRKCA0.45133268
71MAP3K70.45095895
72CSNK1G10.44558116
73PRKCG0.43745446
74CAMK2A0.43347348
75MAP2K60.41935646
76SYK0.40313113
77PRKAA10.40077225
78PNCK0.38539338
79CHUK0.38108240
80PRKACA0.37997301
81MAP2K10.37367114
82ERBB30.37205617
83TNK20.36707617
84PRKACG0.36258757
85CSNK1A1L0.35810985
86MAP3K120.35216717
87IGF1R0.35139325
88PLK20.33055862
89CSNK1A10.32763539
90MAPKAPK50.32648154
91GRK50.32303838
92MAP3K20.31236086
93MAPKAPK30.29770738
94MAP2K70.29483084
95CSNK1G30.28291352
96PRKG10.27409768
97IKBKB0.27268831
98MELK0.25220307
99MKNK10.24063601
100CAMK40.23602908

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.50582163
2Fat digestion and absorption_Homo sapiens_hsa049753.47397918
3Vitamin digestion and absorption_Homo sapiens_hsa049773.42115218
4Linoleic acid metabolism_Homo sapiens_hsa005912.73186351
5Caffeine metabolism_Homo sapiens_hsa002322.66562823
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63475597
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.61190407
8Renin-angiotensin system_Homo sapiens_hsa046142.52298110
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51508296
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.38100767
11Retinol metabolism_Homo sapiens_hsa008302.36850894
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.28150707
13Chemical carcinogenesis_Homo sapiens_hsa052042.21127878
14Mineral absorption_Homo sapiens_hsa049782.19393450
15Histidine metabolism_Homo sapiens_hsa003402.19119335
16Tryptophan metabolism_Homo sapiens_hsa003802.16099216
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01381404
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.99429400
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88358947
20Butanoate metabolism_Homo sapiens_hsa006501.78442966
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73634872
22Starch and sucrose metabolism_Homo sapiens_hsa005001.72750625
23Protein digestion and absorption_Homo sapiens_hsa049741.66214658
24Ether lipid metabolism_Homo sapiens_hsa005651.65564944
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65120172
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62379162
27Arachidonic acid metabolism_Homo sapiens_hsa005901.60127065
28Phototransduction_Homo sapiens_hsa047441.59322778
29ABC transporters_Homo sapiens_hsa020101.56847124
30Glycerolipid metabolism_Homo sapiens_hsa005611.55706984
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.42996605
32Sulfur metabolism_Homo sapiens_hsa009201.41928858
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39451882
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37045871
35Nitrogen metabolism_Homo sapiens_hsa009101.35776070
36Bile secretion_Homo sapiens_hsa049761.35669708
37Arginine biosynthesis_Homo sapiens_hsa002201.34834677
38Propanoate metabolism_Homo sapiens_hsa006401.31774272
39Fatty acid degradation_Homo sapiens_hsa000711.27745106
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.20017755
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07954103
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07843351
43Arginine and proline metabolism_Homo sapiens_hsa003301.07352059
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07017759
45Peroxisome_Homo sapiens_hsa041461.06244562
46PPAR signaling pathway_Homo sapiens_hsa033201.04222779
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.02243973
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90232485
49Selenocompound metabolism_Homo sapiens_hsa004500.85873076
50Sphingolipid metabolism_Homo sapiens_hsa006000.84186678
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83968520
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80893184
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79347695
54Asthma_Homo sapiens_hsa053100.78482936
55beta-Alanine metabolism_Homo sapiens_hsa004100.76586880
56Pancreatic secretion_Homo sapiens_hsa049720.73979492
57Taste transduction_Homo sapiens_hsa047420.71638947
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68228731
59Regulation of autophagy_Homo sapiens_hsa041400.67266298
60Serotonergic synapse_Homo sapiens_hsa047260.63473165
61Glutathione metabolism_Homo sapiens_hsa004800.62054153
62Fructose and mannose metabolism_Homo sapiens_hsa000510.60306183
63Fatty acid metabolism_Homo sapiens_hsa012120.60089895
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.56796887
65Dorso-ventral axis formation_Homo sapiens_hsa043200.54637107
66Ovarian steroidogenesis_Homo sapiens_hsa049130.53706991
67Fatty acid biosynthesis_Homo sapiens_hsa000610.53561270
68Nicotine addiction_Homo sapiens_hsa050330.52275917
69Basal transcription factors_Homo sapiens_hsa030220.52022398
70Olfactory transduction_Homo sapiens_hsa047400.50859929
71Metabolic pathways_Homo sapiens_hsa011000.49594637
72Graft-versus-host disease_Homo sapiens_hsa053320.49201891
73Insulin secretion_Homo sapiens_hsa049110.48871002
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47135101
75Salivary secretion_Homo sapiens_hsa049700.42097736
76Circadian rhythm_Homo sapiens_hsa047100.38916930
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37540398
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36677872
79Galactose metabolism_Homo sapiens_hsa000520.36464843
80Phenylalanine metabolism_Homo sapiens_hsa003600.35944950
81Allograft rejection_Homo sapiens_hsa053300.35831233
82Primary immunodeficiency_Homo sapiens_hsa053400.33400036
83Type I diabetes mellitus_Homo sapiens_hsa049400.31467724
84Fanconi anemia pathway_Homo sapiens_hsa034600.30719927
85Autoimmune thyroid disease_Homo sapiens_hsa053200.29819483
86Renin secretion_Homo sapiens_hsa049240.28887091
87Tyrosine metabolism_Homo sapiens_hsa003500.28527985
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.25474603
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24036307
90Cocaine addiction_Homo sapiens_hsa050300.21708498
91Lysine degradation_Homo sapiens_hsa003100.19334281
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15307115
93Glutamatergic synapse_Homo sapiens_hsa047240.15220002
94Homologous recombination_Homo sapiens_hsa034400.14908713
95Calcium signaling pathway_Homo sapiens_hsa040200.13156941
96Insulin resistance_Homo sapiens_hsa049310.11754628
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11355065
98Morphine addiction_Homo sapiens_hsa050320.10585221
99Sulfur relay system_Homo sapiens_hsa041220.10291744
100Thyroid hormone synthesis_Homo sapiens_hsa049180.10061905

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