SLC6A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to insecticide (GO:0017085)9.56903974
2* catecholamine transport (GO:0051937)7.78711662
3mating behavior (GO:0007617)7.58169147
4synaptic transmission, dopaminergic (GO:0001963)7.57385838
5toxin metabolic process (GO:0009404)7.29010464
6* catecholamine biosynthetic process (GO:0042423)7.04262599
7* catechol-containing compound biosynthetic process (GO:0009713)7.04262599
8neuron cell-cell adhesion (GO:0007158)6.47331632
9negative regulation of neurotransmitter transport (GO:0051589)6.28152715
10regulation of dopamine secretion (GO:0014059)6.10626808
11synaptic vesicle exocytosis (GO:0016079)5.97030133
12glutamate secretion (GO:0014047)5.89286912
13multicellular organismal aging (GO:0010259)5.86254177
14ethanol oxidation (GO:0006069)5.78137530
15* dopamine metabolic process (GO:0042417)5.51228822
16behavioral response to cocaine (GO:0048148)5.35279645
17neurotransmitter catabolic process (GO:0042135)5.13212931
18embryonic camera-type eye morphogenesis (GO:0048596)5.01754372
19regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.98937825
20regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.98937825
21cellular response to nicotine (GO:0071316)4.96463742
22attachment of spindle microtubules to kinetochore (GO:0008608)4.92249985
23glycoside metabolic process (GO:0016137)4.84278442
24tyrosine metabolic process (GO:0006570)4.79792570
25aromatic amino acid family metabolic process (GO:0009072)4.77237658
26synaptic transmission, cholinergic (GO:0007271)4.76110896
27response to amphetamine (GO:0001975)4.66604915
28* neurotransmitter biosynthetic process (GO:0042136)4.62904986
29* monoamine transport (GO:0015844)4.59760575
30inositol phosphate dephosphorylation (GO:0046855)4.57920635
31phosphorylated carbohydrate dephosphorylation (GO:0046838)4.57920635
32positive regulation of cell size (GO:0045793)4.56390086
33positive regulation of glomerulus development (GO:0090193)4.54612821
34establishment of synaptic vesicle localization (GO:0097480)4.53272456
35synaptic vesicle transport (GO:0048489)4.53272456
36cellular response to ammonium ion (GO:0071242)4.40997443
37* phenol-containing compound biosynthetic process (GO:0046189)4.32334060
38regulation of clathrin-mediated endocytosis (GO:2000369)4.32080057
39* response to cocaine (GO:0042220)4.30123589
40positive regulation of vesicle fusion (GO:0031340)4.19997185
41negative regulation of microtubule polymerization (GO:0031115)4.19891199
42* regulation of dopamine metabolic process (GO:0042053)4.18664643
43* regulation of catecholamine metabolic process (GO:0042069)4.18664643
44response to corticosterone (GO:0051412)4.17844021
45benzene-containing compound metabolic process (GO:0042537)4.11884159
46response to water (GO:0009415)4.10763280
47inositol phosphate catabolic process (GO:0071545)4.09078821
48neurotransmitter secretion (GO:0007269)4.00382352
49serotonin metabolic process (GO:0042428)4.00361443
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.94988660
51cerebellar Purkinje cell layer development (GO:0021680)3.93544082
52regulation of short-term neuronal synaptic plasticity (GO:0048172)3.89745909
53ethanol metabolic process (GO:0006067)3.88501031
54* response to nicotine (GO:0035094)3.87637672
55* regulation of neurotransmitter levels (GO:0001505)3.87224731
56regulation of oxidative phosphorylation (GO:0002082)3.84577555
57circadian behavior (GO:0048512)3.82598027
58positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.79054097
59response to amine (GO:0014075)3.74008194
60vocalization behavior (GO:0071625)3.73949837
61opioid receptor signaling pathway (GO:0038003)3.73221273
62behavioral response to nicotine (GO:0035095)3.71324002
63primary amino compound metabolic process (GO:1901160)3.70421594
64cellular response to drug (GO:0035690)3.70341305
65eating behavior (GO:0042755)3.69359371
66* catechol-containing compound metabolic process (GO:0009712)3.69084385
67* catecholamine metabolic process (GO:0006584)3.69084385
68response to zinc ion (GO:0010043)3.62953456
69rhythmic behavior (GO:0007622)3.62009935
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60402655
71neuron maturation (GO:0042551)3.58270495
72* neurotransmitter metabolic process (GO:0042133)3.58237320
73neurofilament cytoskeleton organization (GO:0060052)3.58195355
74multi-organism reproductive behavior (GO:0044705)3.53965226
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53106773
76eye photoreceptor cell development (GO:0042462)3.51499958
77striatum development (GO:0021756)3.50185957
78regulation of synaptic transmission, dopaminergic (GO:0032225)3.47328250
79negative regulation of reactive oxygen species metabolic process (GO:2000378)3.44304968
80* neurotransmitter transport (GO:0006836)3.43825946
81enteric nervous system development (GO:0048484)3.43298284
82energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.41309830
83ATP hydrolysis coupled proton transport (GO:0015991)3.41309830
84response to manganese ion (GO:0010042)3.40321947
85response to mineralocorticoid (GO:0051385)3.39849687
86L-phenylalanine catabolic process (GO:0006559)3.39836675
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.39836675
88protein depolymerization (GO:0051261)3.38544770
89regulation of neurotransmitter uptake (GO:0051580)3.37207190
90positive regulation of cellular response to oxidative stress (GO:1900409)3.37123890
91positive regulation of response to oxidative stress (GO:1902884)3.37123890
92positive regulation of neurotransmitter transport (GO:0051590)3.35432757
93regulation of vesicle fusion (GO:0031338)3.34695100
94establishment of protein localization to mitochondrial membrane (GO:0090151)3.34301121
95establishment of vesicle localization (GO:0051650)3.33632849
96insulin secretion (GO:0030073)3.31421350
97embryonic eye morphogenesis (GO:0048048)3.30720806
98energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30467753
99ATP synthesis coupled proton transport (GO:0015986)3.30467753
100reproductive behavior (GO:0019098)3.29769362
101response to salt stress (GO:0009651)3.28939099
102synaptic vesicle endocytosis (GO:0048488)3.28887195
103photoreceptor cell development (GO:0042461)3.28792112
104regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25793318
105innervation (GO:0060384)3.25108932
106auditory behavior (GO:0031223)3.24247347
107norepinephrine metabolic process (GO:0042415)3.24192100
108synaptic vesicle maturation (GO:0016188)3.23621157
109regulation of synaptic vesicle transport (GO:1902803)3.20647341
110intraspecies interaction between organisms (GO:0051703)3.18603100
111social behavior (GO:0035176)3.18603100
112lactate metabolic process (GO:0006089)3.17251339
113response to xenobiotic stimulus (GO:0009410)3.16258737
114pigmentation (GO:0043473)3.15333208
115respiratory electron transport chain (GO:0022904)3.13677609
116neuron-neuron synaptic transmission (GO:0007270)3.13264308
117neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.12873324
118regulation of catecholamine secretion (GO:0050433)3.11307726
119response to electrical stimulus (GO:0051602)3.10896913
120regulation of glomerulus development (GO:0090192)3.09967489
121regulation of synapse structural plasticity (GO:0051823)3.09504039
122endocytic recycling (GO:0032456)3.07720093
123positive regulation of growth hormone secretion (GO:0060124)3.07343901
124neuronal action potential (GO:0019228)3.07180771
125regulation of hydrogen peroxide metabolic process (GO:0010310)3.07174386
126electron transport chain (GO:0022900)3.06789113
127regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06536269
128negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04739715
129Notch signaling involved in heart development (GO:0061314)3.04734033
130response to histamine (GO:0034776)3.01315340
131transferrin transport (GO:0033572)3.00182186
132cellular response to epinephrine stimulus (GO:0071872)2.99353460
133acid secretion (GO:0046717)2.98538420
134grooming behavior (GO:0007625)2.97726627
135regulation of synaptic vesicle exocytosis (GO:2000300)2.97256055
136negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97119803
137organic cation transport (GO:0015695)2.93425352
138sulfation (GO:0051923)2.92309015
139negative regulation of membrane potential (GO:0045837)2.87562850
140regulation of neurotransmitter transport (GO:0051588)2.87249719
141positive regulation of potassium ion transmembrane transport (GO:1901381)2.81970966
142alkaloid metabolic process (GO:0009820)14.2716007
143* dopamine biosynthetic process (GO:0042416)12.2290028
144* dopamine transport (GO:0015872)11.2740042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67481337
2TAF15_26573619_Chip-Seq_HEK293_Human4.77522396
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.15305169
4GBX2_23144817_ChIP-Seq_PC3_Human3.41946606
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.35141786
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.33553547
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.14175030
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05889256
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99564513
10IGF1R_20145208_ChIP-Seq_DFB_Human2.87603284
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.82439140
12ZNF274_21170338_ChIP-Seq_K562_Hela2.56875853
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.55255050
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30692608
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30427087
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28457415
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27670519
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26040583
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25671154
20REST_21632747_ChIP-Seq_MESCs_Mouse2.19217342
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17241095
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16609459
23NR3C1_23031785_ChIP-Seq_PC12_Mouse2.16192380
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13622402
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12183959
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05693917
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05693917
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00453606
29BCAT_22108803_ChIP-Seq_LS180_Human1.97405312
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95469449
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95223355
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94913514
33TP53_16413492_ChIP-PET_HCT116_Human1.87667456
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.85160146
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.83709897
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.77471599
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76964269
38SMAD4_21799915_ChIP-Seq_A2780_Human1.76002047
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.75947556
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73301313
41* DROSHA_22980978_ChIP-Seq_HELA_Human1.73190295
42P300_19829295_ChIP-Seq_ESCs_Human1.72489736
43RNF2_27304074_Chip-Seq_NSC_Mouse1.57359235
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57317180
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56937251
46VDR_22108803_ChIP-Seq_LS180_Human1.56642511
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.56052082
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.54235184
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.52663905
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44556983
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.42272325
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.40283545
53* EZH2_27294783_Chip-Seq_ESCs_Mouse1.40206105
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39572431
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38672280
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.38240023
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.36872749
58TP53_18474530_ChIP-ChIP_U2OS_Human1.36417137
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36391359
60FUS_26573619_Chip-Seq_HEK293_Human1.34265495
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29541912
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28162714
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27964452
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.26405156
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25177056
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23712542
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21744011
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20649839
69ER_23166858_ChIP-Seq_MCF-7_Human1.19986446
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19625789
71AR_25329375_ChIP-Seq_VCAP_Human1.19334925
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12436370
73* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12327936
74STAT3_23295773_ChIP-Seq_U87_Human1.11357688
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10405702
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09701218
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09516940
78CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08844592
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08440987
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07376409
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06718215
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06318408
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.06173883
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05345588
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.05345588
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.04997023
87AR_21572438_ChIP-Seq_LNCaP_Human1.04962475
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03683796
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03300580
90OCT4_19829295_ChIP-Seq_ESCs_Human1.03173539
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.01558482
92TCF4_23295773_ChIP-Seq_U87_Human1.01437642
93SMAD4_21741376_ChIP-Seq_HESCs_Human1.00545884
94JUN_21703547_ChIP-Seq_K562_Human1.00085997
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99291625
96EWS_26573619_Chip-Seq_HEK293_Human0.99013792
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98969424
98TET1_21490601_ChIP-Seq_MESCs_Mouse0.97777026
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97208651
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96621695
101MYC_19915707_ChIP-ChIP_AK7_Human0.96360991
102MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.94679765
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93067240
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92129768
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92129768
106STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90178003
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89641434
108STAT1_17558387_ChIP-Seq_HELA_Human0.89574633
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.89552516
110RING1B_27294783_Chip-Seq_ESCs_Mouse0.87708634
111GATA1_26923725_Chip-Seq_HPCs_Mouse0.86881717
112AR_19668381_ChIP-Seq_PC3_Human0.86612833
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86144417
114KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86140520
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84885725
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84177287
117KDM2B_26808549_Chip-Seq_REH_Human0.83463044
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83042049
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82853765
120REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82807833
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81475738
122CTCF_27219007_Chip-Seq_Bcells_Human0.80607959
123CBX2_27304074_Chip-Seq_ESCs_Mouse0.80350026
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80147924
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80036633
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80036633
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79913931
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79463140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.09924237
2MP0003880_abnormal_central_pattern6.38442872
3* MP0001905_abnormal_dopamine_level5.52046867
4MP0001529_abnormal_vocalization4.68502526
5MP0006276_abnormal_autonomic_nervous3.84348464
6MP0004859_abnormal_synaptic_plasticity3.57272108
7MP0002822_catalepsy3.50179192
8MP0005248_abnormal_Harderian_gland2.97428899
9* MP0003635_abnormal_synaptic_transmissio2.86074574
10MP0002909_abnormal_adrenal_gland2.53675892
11MP0002064_seizures2.46047518
12MP0005409_darkened_coat_color2.46023991
13MP0009745_abnormal_behavioral_response2.43779223
14MP0001501_abnormal_sleep_pattern2.37651217
15MP0003122_maternal_imprinting2.34417993
16MP0005423_abnormal_somatic_nervous2.28646210
17MP0001188_hyperpigmentation2.12877356
18MP0002876_abnormal_thyroid_physiology2.05502071
19MP0000569_abnormal_digit_pigmentation2.00920088
20MP0001486_abnormal_startle_reflex1.98676695
21MP0001968_abnormal_touch/_nociception1.97722932
22MP0002736_abnormal_nociception_after1.93497602
23MP0001664_abnormal_digestion1.92185454
24MP0002138_abnormal_hepatobiliary_system1.91898447
25* MP0002572_abnormal_emotion/affect_behav1.89192654
26MP0002733_abnormal_thermal_nociception1.88297989
27* MP0002063_abnormal_learning/memory/cond1.84668988
28MP0002638_abnormal_pupillary_reflex1.83661876
29MP0005535_abnormal_body_temperature1.82911029
30* MP0004924_abnormal_behavior1.81668516
31* MP0005386_behavior/neurological_phenoty1.81668516
32MP0002837_dystrophic_cardiac_calcinosis1.78146129
33MP0001440_abnormal_grooming_behavior1.72958327
34MP0002067_abnormal_sensory_capabilities1.64638042
35* MP0009046_muscle_twitch1.62805198
36MP0003868_abnormal_feces_composition1.58149710
37MP0002877_abnormal_melanocyte_morpholog1.45064086
38MP0001970_abnormal_pain_threshold1.44310645
39MP0000639_abnormal_adrenal_gland1.41792973
40MP0002332_abnormal_exercise_endurance1.41400920
41MP0002090_abnormal_vision1.36615909
42MP0002184_abnormal_innervation1.35946355
43MP0000538_abnormal_urinary_bladder1.34604148
44MP0002734_abnormal_mechanical_nocicepti1.33391769
45* MP0002272_abnormal_nervous_system1.30267103
46MP0003632_abnormal_nervous_system1.29654645
47* MP0002557_abnormal_social/conspecific_i1.29343560
48MP0004043_abnormal_pH_regulation1.23855177
49MP0004270_analgesia1.22654644
50MP0005646_abnormal_pituitary_gland1.17094817
51MP0004811_abnormal_neuron_physiology1.12439915
52MP0002089_abnormal_postnatal_growth/wei1.11790604
53* MP0002066_abnormal_motor_capabilities/c1.10537526
54MP0004142_abnormal_muscle_tone1.09627213
55MP0005388_respiratory_system_phenotype1.08157955
56MP0002133_abnormal_respiratory_system1.08157955
57MP0006072_abnormal_retinal_apoptosis1.03991406
58MP0003315_abnormal_perineum_morphology1.02749679
59MP0000955_abnormal_spinal_cord1.02120539
60MP0002735_abnormal_chemical_nociception1.00495557
61MP0000230_abnormal_systemic_arterial1.00014673
62MP0000778_abnormal_nervous_system0.99202312
63MP0003866_abnormal_defecation0.98547069
64MP0003879_abnormal_hair_cell0.97709439
65MP0008874_decreased_physiological_sensi0.97151829
66* MP0008872_abnormal_physiological_respon0.96076025
67MP0005187_abnormal_penis_morphology0.95794802
68MP0003329_amyloid_beta_deposits0.95626588
69MP0000751_myopathy0.95034117
70MP0003631_nervous_system_phenotype0.94274423
71MP0001944_abnormal_pancreas_morphology0.92072596
72MP0000013_abnormal_adipose_tissue0.90086547
73MP0004883_abnormal_blood_vessel0.89902226
74MP0005171_absent_coat_pigmentation0.87699521
75MP0002751_abnormal_autonomic_nervous0.87114806
76MP0000747_muscle_weakness0.85821187
77MP0009703_decreased_birth_body0.85007666
78MP0001502_abnormal_circadian_rhythm0.83316205
79MP0004742_abnormal_vestibular_system0.83225840
80MP0003718_maternal_effect0.81637787
81MP0003786_premature_aging0.79954395
82MP0001984_abnormal_olfaction0.79485372
83MP0005379_endocrine/exocrine_gland_phen0.79099901
84MP0006035_abnormal_mitochondrial_morpho0.78000171
85* MP0002882_abnormal_neuron_morphology0.77314327
86MP0000534_abnormal_ureter_morphology0.74763831
87MP0008875_abnormal_xenobiotic_pharmacok0.74670411
88MP0001177_atelectasis0.74213835
89MP0003890_abnormal_embryonic-extraembry0.73700649
90MP0001756_abnormal_urination0.73595397
91MP0004084_abnormal_cardiac_muscle0.72856180
92MP0003787_abnormal_imprinting0.71697473
93MP0005584_abnormal_enzyme/coenzyme_acti0.71613415
94MP0001485_abnormal_pinna_reflex0.70233046
95MP0010386_abnormal_urinary_bladder0.69759990
96MP0002069_abnormal_eating/drinking_beha0.69218252
97MP0003195_calcinosis0.67618319
98MP0003942_abnormal_urinary_system0.66631859
99MP0001299_abnormal_eye_distance/0.66626271
100MP0002163_abnormal_gland_morphology0.65872844
101MP0004885_abnormal_endolymph0.65617358
102MP0002229_neurodegeneration0.65071156
103MP0005410_abnormal_fertilization0.64792428
104MP0005394_taste/olfaction_phenotype0.63533282
105MP0005499_abnormal_olfactory_system0.63533282
106MP0008569_lethality_at_weaning0.63235155
107MP0001340_abnormal_eyelid_morphology0.62974777
108MP0002254_reproductive_system_inflammat0.62374031
109MP0002009_preneoplasia0.62372236
110MP0000462_abnormal_digestive_system0.61903359
111MP0005058_abnormal_lysosome_morphology0.60913511
112MP0010234_abnormal_vibrissa_follicle0.60673168
113MP0001943_abnormal_respiration0.60492976
114MP0005164_abnormal_response_to0.60472619
115MP0004858_abnormal_nervous_system0.60472400
116MP0005266_abnormal_metabolism0.60127906
117MP0005376_homeostasis/metabolism_phenot0.59225774
118MP0001765_abnormal_ion_homeostasis0.58711706
119MP0010770_preweaning_lethality0.58151867
120MP0002082_postnatal_lethality0.58151867
121* MP0002152_abnormal_brain_morphology0.57763957
122MP0001963_abnormal_hearing_physiology0.57377412
123MP0003183_abnormal_peptide_metabolism0.57262683
124MP0010768_mortality/aging0.56892621
125MP0003633_abnormal_nervous_system0.56595127
126MP0005623_abnormal_meninges_morphology0.56145482
127MP0005310_abnormal_salivary_gland0.55296612
128MP0006036_abnormal_mitochondrial_physio0.53964927
129MP0008873_increased_physiological_sensi0.53554249
130MP0000681_abnormal_thyroid_gland0.52719073
131MP0005551_abnormal_eye_electrophysiolog0.50088254
132MP0004145_abnormal_muscle_electrophysio0.48970345
133MP0002233_abnormal_nose_morphology0.46516176
134MP0004085_abnormal_heartbeat0.46414778
135MP0001346_abnormal_lacrimal_gland0.45375121

Predicted human phenotypes

RankGene SetZ-score
1Pheochromocytoma (HP:0002666)7.65239538
2Postural instability (HP:0002172)7.14671797
3Neuroendocrine neoplasm (HP:0100634)6.96915603
4Abnormal pupillary function (HP:0007686)6.66207256
5Hypothermia (HP:0002045)6.60921174
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.56639640
7Visual hallucinations (HP:0002367)6.18434490
8Potter facies (HP:0002009)5.91304461
9Facial shape deformation (HP:0011334)5.91304461
10Failure to thrive in infancy (HP:0001531)5.65800788
11Cerebral hemorrhage (HP:0001342)5.19662400
12Hypokinesia (HP:0002375)4.91954156
13Cerebral inclusion bodies (HP:0100314)4.75666137
14Limb hypertonia (HP:0002509)4.64144323
15Abnormality of the parathyroid morphology (HP:0011766)4.33189583
16Hypoventilation (HP:0002791)4.01411471
17Neoplasm of the peripheral nervous system (HP:0100007)3.86599013
18Progressive cerebellar ataxia (HP:0002073)3.77018967
19Slow saccadic eye movements (HP:0000514)3.75601735
20Acute necrotizing encephalopathy (HP:0006965)3.62629551
21Hypercortisolism (HP:0001578)3.60855726
22Diminished movement (HP:0002374)3.56989169
23Abnormality of calcium-phosphate metabolism (HP:0100530)3.51614945
24Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.48575343
25Abnormal mitochondria in muscle tissue (HP:0008316)3.36928776
26Abnormality of saccadic eye movements (HP:0000570)3.31884372
27Myokymia (HP:0002411)3.28996698
28Focal seizures (HP:0007359)3.27364822
29Abnormality of aromatic amino acid family metabolism (HP:0004338)3.27071969
30Mitochondrial inheritance (HP:0001427)3.21172165
31Progressive macrocephaly (HP:0004481)3.16598293
32Delusions (HP:0000746)3.02470007
33Febrile seizures (HP:0002373)2.99481315
34Anosmia (HP:0000458)2.91382255
35Acute encephalopathy (HP:0006846)2.88085451
36Postural tremor (HP:0002174)2.87996160
37Vacuolated lymphocytes (HP:0001922)2.85373115
38Focal motor seizures (HP:0011153)2.83830629
39Myoclonus (HP:0001336)2.83503985
40Diplopia (HP:0000651)2.79464758
41Abnormality of binocular vision (HP:0011514)2.79464758
42Progressive inability to walk (HP:0002505)2.78327785
43Emotional lability (HP:0000712)2.74403114
44* Bradykinesia (HP:0002067)2.72491297
45Anxiety (HP:0000739)2.69383452
46Increased CSF lactate (HP:0002490)2.61645335
47Truncal ataxia (HP:0002078)2.59981688
48Hepatocellular necrosis (HP:0001404)2.52861441
49Retinal dysplasia (HP:0007973)2.52164864
50Neurofibrillary tangles (HP:0002185)2.49291479
51* Muscular hypotonia of the trunk (HP:0008936)2.49011350
52Hyperparathyroidism (HP:0000843)2.48241339
53Vaginal atresia (HP:0000148)2.46677229
54Neuroblastoma (HP:0003006)2.46144868
55Primitive neuroectodermal tumor (HP:0030065)2.46144868
56Neuroblastic tumors (HP:0004376)2.46144868
57Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.46144868
58Genital tract atresia (HP:0001827)2.43234132
59Disproportionate tall stature (HP:0001519)2.43090269
60* Rigidity (HP:0002063)2.42022979
61Generalized tonic-clonic seizures (HP:0002069)2.41345880
62Hypotension (HP:0002615)2.37045025
63Thyroid carcinoma (HP:0002890)2.29766108
64Bicornuate uterus (HP:0000813)2.26882714
65Progressive neurologic deterioration (HP:0002344)2.26647847
66Atonic seizures (HP:0010819)2.19945006
67Increased hepatocellular lipid droplets (HP:0006565)2.18607135
68Depression (HP:0000716)2.18022313
69Mask-like facies (HP:0000298)2.15567112
70Supranuclear gaze palsy (HP:0000605)2.13476391
71Optic disc pallor (HP:0000543)2.12080085
72Horizontal nystagmus (HP:0000666)2.11336738
73Poor suck (HP:0002033)2.11084194
74Episodic fever (HP:0001954)2.10076404
75Cerebral edema (HP:0002181)2.09053036
76Abnormal eating behavior (HP:0100738)2.08352358
77Ventricular fibrillation (HP:0001663)2.07162918
78Orthostatic hypotension (HP:0001278)2.05775103
79Status epilepticus (HP:0002133)2.05277252
80Fetal akinesia sequence (HP:0001989)2.01333467
81Gait ataxia (HP:0002066)2.01133809
82* Limb dystonia (HP:0002451)12.5230953
83Type II lissencephaly (HP:0007260)1.98230294
84Torticollis (HP:0000473)1.97598187
85Craniofacial dystonia (HP:0012179)1.96521182
86Abnormal gallbladder physiology (HP:0012438)1.96194346
87Cholecystitis (HP:0001082)1.96194346
88Rapidly progressive (HP:0003678)1.94936671
89Bowel diverticulosis (HP:0005222)1.91820169
90Resting tremor (HP:0002322)1.90186546
91Dysautonomia (HP:0002459)1.89012893
92Lipid accumulation in hepatocytes (HP:0006561)1.88746540
93Paraparesis (HP:0002385)1.88734841
94Agitation (HP:0000713)1.88346349
95Choreoathetosis (HP:0001266)1.88158712
96Neuronal loss in central nervous system (HP:0002529)1.85888155
97Epileptic encephalopathy (HP:0200134)1.84926467
98Focal dystonia (HP:0004373)1.83293803
99Papilledema (HP:0001085)1.82498956
100Leukodystrophy (HP:0002415)1.81929014
101Hepatic necrosis (HP:0002605)1.81102995
102Renal Fanconi syndrome (HP:0001994)1.79952363
103Goiter (HP:0000853)1.77365828
104Inability to walk (HP:0002540)1.75767815
105Gaze-evoked nystagmus (HP:0000640)1.73838819
106Increased intramyocellular lipid droplets (HP:0012240)1.73612618
107Coronal craniosynostosis (HP:0004440)1.73594944
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.72628791
109Abnormality of ocular smooth pursuit (HP:0000617)1.72489334
110Akinesia (HP:0002304)1.71218178
111Neonatal onset (HP:0003623)1.70961553
112Esotropia (HP:0000565)1.70018400
113Adrenal overactivity (HP:0002717)1.69829771
114Respiratory failure (HP:0002878)1.69100506
115Renal dysplasia (HP:0000110)1.68157716
116Exercise intolerance (HP:0003546)1.68135046
117Dialeptic seizures (HP:0011146)1.64495913
118Polyphagia (HP:0002591)1.63874318
119Abnormal hair whorl (HP:0010721)1.63690785
120Absence seizures (HP:0002121)1.63533012
121Incomplete penetrance (HP:0003829)1.62644771
122Psychosis (HP:0000709)1.61648627
123Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.60908271
124Hemiplegia (HP:0002301)1.60867963
125Dysmetria (HP:0001310)1.60225483
126Mutism (HP:0002300)1.59539521
127Dysostosis multiplex (HP:0000943)1.57346738
128Oligodactyly (hands) (HP:0001180)1.56580920
129Exertional dyspnea (HP:0002875)1.52741681
130Gout (HP:0001997)1.50944994
131Bradycardia (HP:0001662)1.45528238
132Striae distensae (HP:0001065)1.44627405
133Respiratory difficulties (HP:0002880)1.42983896
134Variable expressivity (HP:0003828)1.42512550
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.39120046
136Fibular hypoplasia (HP:0003038)1.36366115
137Irritability (HP:0000737)1.36320256
138Dementia (HP:0000726)1.35901590
139Thickened helices (HP:0000391)1.34582921
140Hyperphosphaturia (HP:0003109)1.34252277
141Epileptiform EEG discharges (HP:0011182)1.34167928
142Gait imbalance (HP:0002141)1.31452779
143Drooling (HP:0002307)1.31138183
144Poor eye contact (HP:0000817)1.30707431
145EEG with generalized epileptiform discharges (HP:0011198)1.28696901
146Hypsarrhythmia (HP:0002521)1.28330062
147Generalized myoclonic seizures (HP:0002123)1.28115305
148Metabolic alkalosis (HP:0200114)1.25640764
149Excessive salivation (HP:0003781)1.21745000
150Impaired smooth pursuit (HP:0007772)1.18558112
151Chronic hepatic failure (HP:0100626)1.15602067
152Zonular cataract (HP:0010920)1.15318350
153Glossoptosis (HP:0000162)1.14576411
154Cerebral hypomyelination (HP:0006808)1.13662331
155Ankyloglossia (HP:0010296)1.12953474
156Spastic tetraplegia (HP:0002510)1.12639205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB17.13935447
2MAPKAPK56.12010754
3MAP3K124.71617134
4CSNK1G34.02189725
5GRK53.64950245
6PINK13.50768867
7CSNK1G23.46536789
8PNCK3.24153310
9GRK63.22174371
10CSNK1G13.05691959
11MAP3K92.86004376
12PLK22.50053030
13MAP3K42.47731775
14ARAF2.41045937
15FGR2.30866211
16MAP2K72.27874044
17MAP2K42.23972796
18RET2.02725713
19PTK2B1.87607574
20BCKDK1.78604603
21WNK41.77000329
22MINK11.71217708
23ADRBK21.69989605
24STK391.69852516
25PKN21.69670549
26MAP3K131.48038475
27CAMK2B1.44557295
28NTRK11.40580566
29CDK151.34704419
30CDK181.32404768
31CAMK2D1.28664668
32EPHA41.28140710
33LATS21.27224292
34NME11.26745603
35CDK141.23821567
36CDK11A1.22327773
37KSR21.20588173
38PTK21.19252903
39MARK11.15464910
40CDK51.05100565
41TSSK61.02523035
42NTRK31.00872523
43CAMK2G0.98386563
44* CAMK2A0.94383679
45ADRBK10.90190617
46FLT30.88933027
47CASK0.81977396
48MYLK0.79436297
49DYRK1A0.78462820
50ERBB40.78454383
51RPS6KA50.78096392
52NTRK20.77058786
53PLK30.75363220
54EIF2AK20.68297085
55EEF2K0.67889923
56BMPR1B0.66747702
57SCYL20.65859227
58UHMK10.65588183
59FES0.64616721
60MOS0.62942157
61SIK20.62405725
62MAPK130.61426440
63PRKCG0.59914967
64STK160.59669533
65KSR10.59174054
66PHKG10.52339226
67PHKG20.52339226
68RIPK40.52284392
69WNK10.51826808
70MAP3K50.51214776
71SYK0.51152218
72CDK190.50684298
73MAP3K110.50616974
74OXSR10.50318623
75CAMKK20.50032180
76CAMK1G0.46901455
77MARK20.45939829
78PAK30.43515939
79TYRO30.42718128
80CSNK1A10.42161072
81CSNK1D0.41888032
82MAP3K10.40206669
83CHEK20.40007544
84BRAF0.38685844
85TYK20.37777007
86PAK60.36951048
87ROCK20.36356637
88CSNK1E0.35439047
89SGK10.33320676
90FYN0.32658569
91CDK90.31619474
92LMTK20.30451171
93RAF10.29879477
94PRKAA10.28511579
95MAPKAPK30.28066984
96CAMKK10.26454925
97PRKACA0.23894250
98SGK4940.23739669
99SGK2230.23739669
100MAPKAPK20.23342797
101PRKACG0.23304692
102DAPK10.22655563
103TRPM70.22396744
104STK110.21991095
105MAP2K10.21773987
106ABL20.21560399
107PRKACB0.21555583
108SIK10.21527548
109ACVR1B0.21354970
110PRKCZ0.21088685
111WNK30.20530772
112MAPK120.20464224
113CSNK2A20.20021337
114IGF1R0.19350304
115ERN10.19197117
116PKN10.18382548
117PRKCH0.18252623
118BMPR20.16838855
119PDK10.16262595
120DYRK20.16236021
121LYN0.15962047
122CSNK1A1L0.15823510
123RPS6KA30.14800384
124DAPK20.14564817
125PRKCB0.14343592
126BMX0.14316657
127FER0.14143345
128PRKCA0.13976284
129SGK20.12081443
130PRKG20.11834978
131PRKG10.11753143
132STK380.11644571
133CDK30.11291398
134SRC0.11254593
135BCR0.11129999
136PRKCE0.10039408
137BRSK20.09215381
138ROCK10.06210930
139MAPK100.01769221
140PRKD10.00926850
141INSRR-0.0067065
142TLK1-0.0050762
143MAPK8-0.0004662

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.65924569
2* Cocaine addiction_Homo sapiens_hsa050304.38307454
3Parkinsons disease_Homo sapiens_hsa050123.95861757
4Oxidative phosphorylation_Homo sapiens_hsa001903.80940995
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.66594388
6* Amphetamine addiction_Homo sapiens_hsa050313.14388884
7Collecting duct acid secretion_Homo sapiens_hsa049663.11990861
8Tyrosine metabolism_Homo sapiens_hsa003502.92019647
9Phenylalanine metabolism_Homo sapiens_hsa003602.91306222
10Nicotine addiction_Homo sapiens_hsa050332.73474832
11* Dopaminergic synapse_Homo sapiens_hsa047282.65432445
12Folate biosynthesis_Homo sapiens_hsa007902.55831107
13Alzheimers disease_Homo sapiens_hsa050102.51336475
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.44515009
15Serotonergic synapse_Homo sapiens_hsa047262.29824152
16Vibrio cholerae infection_Homo sapiens_hsa051102.11947577
17Selenocompound metabolism_Homo sapiens_hsa004501.88941647
18Huntingtons disease_Homo sapiens_hsa050161.87504971
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82252361
20Cholinergic synapse_Homo sapiens_hsa047251.81177058
21Histidine metabolism_Homo sapiens_hsa003401.79810942
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.65527842
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59326118
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58763028
25GABAergic synapse_Homo sapiens_hsa047271.52505465
26Cardiac muscle contraction_Homo sapiens_hsa042601.50270341
27Long-term potentiation_Homo sapiens_hsa047201.50004451
28Pyruvate metabolism_Homo sapiens_hsa006201.45814971
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.40833391
30Insulin secretion_Homo sapiens_hsa049111.37586012
31Long-term depression_Homo sapiens_hsa047301.36432777
32Circadian entrainment_Homo sapiens_hsa047131.34163999
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28827671
34Sphingolipid metabolism_Homo sapiens_hsa006001.27736275
35ECM-receptor interaction_Homo sapiens_hsa045121.27114244
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22573059
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22427144
38Gap junction_Homo sapiens_hsa045401.21154371
39Glutamatergic synapse_Homo sapiens_hsa047241.17731091
40* Alcoholism_Homo sapiens_hsa050341.15406423
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14806493
42Salivary secretion_Homo sapiens_hsa049701.10242849
43Calcium signaling pathway_Homo sapiens_hsa040201.10018923
44African trypanosomiasis_Homo sapiens_hsa051431.08531958
45Morphine addiction_Homo sapiens_hsa050321.07615445
46Renin secretion_Homo sapiens_hsa049241.07549148
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07163910
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02097217
49Rheumatoid arthritis_Homo sapiens_hsa053231.00966125
50Fatty acid elongation_Homo sapiens_hsa000620.96125921
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95941983
52Vitamin B6 metabolism_Homo sapiens_hsa007500.93177205
53Gastric acid secretion_Homo sapiens_hsa049710.92906631
54Olfactory transduction_Homo sapiens_hsa047400.91030651
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88872503
56Tryptophan metabolism_Homo sapiens_hsa003800.86424213
57GnRH signaling pathway_Homo sapiens_hsa049120.84999515
58Estrogen signaling pathway_Homo sapiens_hsa049150.81537391
59Taste transduction_Homo sapiens_hsa047420.79274311
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77987081
61Thyroid cancer_Homo sapiens_hsa052160.77370073
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72774345
63Fatty acid biosynthesis_Homo sapiens_hsa000610.71920784
64Propanoate metabolism_Homo sapiens_hsa006400.68496521
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68036353
66Phagosome_Homo sapiens_hsa041450.63141694
67Thyroid hormone synthesis_Homo sapiens_hsa049180.61777870
68Retinol metabolism_Homo sapiens_hsa008300.60576693
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58714313
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.57139669
71Oxytocin signaling pathway_Homo sapiens_hsa049210.56530406
72Glucagon signaling pathway_Homo sapiens_hsa049220.54496168
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50885901
74Melanogenesis_Homo sapiens_hsa049160.50859972
75ABC transporters_Homo sapiens_hsa020100.50059992
76Sulfur metabolism_Homo sapiens_hsa009200.47845718
77Dorso-ventral axis formation_Homo sapiens_hsa043200.47632790
78Ether lipid metabolism_Homo sapiens_hsa005650.43261448
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42666851
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42124038
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.39376042
82Base excision repair_Homo sapiens_hsa034100.38399702
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38149387
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33676731
85Prion diseases_Homo sapiens_hsa050200.32870093
86Prolactin signaling pathway_Homo sapiens_hsa049170.31639306
87Type II diabetes mellitus_Homo sapiens_hsa049300.31472576
88Pancreatic secretion_Homo sapiens_hsa049720.30721715
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30178351
90Other glycan degradation_Homo sapiens_hsa005110.29586518
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29046884
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.27632733
93Butanoate metabolism_Homo sapiens_hsa006500.26274931
94cAMP signaling pathway_Homo sapiens_hsa040240.25914532
95Proteasome_Homo sapiens_hsa030500.25571520
96Metabolic pathways_Homo sapiens_hsa011000.25253187
97ErbB signaling pathway_Homo sapiens_hsa040120.24659051
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23920607
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23915706
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.22843876
101Melanoma_Homo sapiens_hsa052180.21520657
102Axon guidance_Homo sapiens_hsa043600.21499312
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.20542697
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20425538
105Inositol phosphate metabolism_Homo sapiens_hsa005620.20381772
106Carbon metabolism_Homo sapiens_hsa012000.19265632
107Oocyte meiosis_Homo sapiens_hsa041140.18924262
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.18359392
109Nitrogen metabolism_Homo sapiens_hsa009100.18264390
110Ras signaling pathway_Homo sapiens_hsa040140.18166598
111Steroid biosynthesis_Homo sapiens_hsa001000.16885305
112mRNA surveillance pathway_Homo sapiens_hsa030150.16079273
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15905944
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14477707
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.13827623
116Ovarian steroidogenesis_Homo sapiens_hsa049130.13747490
117Sulfur relay system_Homo sapiens_hsa041220.13709094
118Glioma_Homo sapiens_hsa052140.13404930
119Linoleic acid metabolism_Homo sapiens_hsa005910.12481145
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12231448
121Dilated cardiomyopathy_Homo sapiens_hsa054140.12052884
122Fatty acid metabolism_Homo sapiens_hsa012120.11517185
123Endocytosis_Homo sapiens_hsa041440.11011700
124Phototransduction_Homo sapiens_hsa047440.09399288
125Circadian rhythm_Homo sapiens_hsa047100.08757279
126beta-Alanine metabolism_Homo sapiens_hsa004100.08284375
127MAPK signaling pathway_Homo sapiens_hsa040100.07981581
128Lysosome_Homo sapiens_hsa041420.06813079
129Bile secretion_Homo sapiens_hsa049760.06711729

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