SLC6A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)9.51439876
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.15762078
3piRNA metabolic process (GO:0034587)8.41183370
4regulation of acrosome reaction (GO:0060046)8.28583752
5regulation of retinoic acid receptor signaling pathway (GO:0048385)7.80234663
6meiotic cell cycle (GO:0051321)7.58295746
7regulation of meiosis I (GO:0060631)7.29311536
8central nervous system myelination (GO:0022010)7.07181448
9axon ensheathment in central nervous system (GO:0032291)7.07181448
10retinal cone cell development (GO:0046549)6.59356272
11oocyte development (GO:0048599)6.47432289
12positive regulation of histone H3-K4 methylation (GO:0051571)6.44405875
13DNA methylation involved in gamete generation (GO:0043046)6.20176766
14multicellular organism reproduction (GO:0032504)6.13881527
15regulation of histone H3-K9 methylation (GO:0051570)6.12067987
16positive regulation of gastrulation (GO:2000543)5.92785527
17female gamete generation (GO:0007292)5.79279506
18negative regulation of histone methylation (GO:0031061)5.31575538
19negative regulation of reproductive process (GO:2000242)5.11317667
20regulation of cell maturation (GO:1903429)5.09523876
21regulation of steroid hormone secretion (GO:2000831)5.09255564
22mitotic chromosome condensation (GO:0007076)4.97175487
23gene silencing by RNA (GO:0031047)4.91001468
24protein kinase C signaling (GO:0070528)4.85321128
25embryonic body morphogenesis (GO:0010172)4.80613361
26neuronal action potential propagation (GO:0019227)4.69314714
27righting reflex (GO:0060013)4.61941406
28neuron fate determination (GO:0048664)4.47061050
29protein localization to chromosome, centromeric region (GO:0071459)4.44120619
30positive regulation of uterine smooth muscle contraction (GO:0070474)4.36207563
31positive regulation of humoral immune response (GO:0002922)4.24733855
32synapsis (GO:0007129)4.17238616
33presynaptic membrane organization (GO:0097090)4.15951195
34male meiosis I (GO:0007141)4.09484201
35positive regulation of mitotic sister chromatid separation (GO:1901970)4.07559454
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.07559454
37positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.07559454
38neuron cell-cell adhesion (GO:0007158)4.03613251
39startle response (GO:0001964)4.03562661
40positive regulation of chromosome segregation (GO:0051984)4.03392157
41mitotic metaphase plate congression (GO:0007080)4.03148331
42adult walking behavior (GO:0007628)4.01891682
43regulation of histone H3-K4 methylation (GO:0051569)3.99153134
44regulation of meiosis (GO:0040020)3.98668877
45primitive streak formation (GO:0090009)3.97666421
46reproduction (GO:0000003)3.96943150
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.94602044
48phosphorelay signal transduction system (GO:0000160)3.94589763
49ionotropic glutamate receptor signaling pathway (GO:0035235)3.93272746
50positive regulation of reproductive process (GO:2000243)3.90786818
51body morphogenesis (GO:0010171)3.90595948
52presynaptic membrane assembly (GO:0097105)3.87322763
53centriole replication (GO:0007099)3.86751996
54protein localization to kinetochore (GO:0034501)3.82241657
55transmission of nerve impulse (GO:0019226)3.80706939
56* L-amino acid import (GO:0043092)3.77204086
57positive regulation of histone methylation (GO:0031062)3.77182035
58attachment of spindle microtubules to kinetochore (GO:0008608)3.75404923
59neuromuscular process controlling posture (GO:0050884)3.71792948
60DNA alkylation (GO:0006305)3.70614187
61DNA methylation (GO:0006306)3.70614187
62long-chain fatty acid biosynthetic process (GO:0042759)3.68206887
63phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.68123959
64regulation of steroid hormone biosynthetic process (GO:0090030)3.67796213
65negative regulation of execution phase of apoptosis (GO:1900118)3.65057056
66establishment of chromosome localization (GO:0051303)3.62805353
67import into cell (GO:0098657)3.62451725
68glutamate receptor signaling pathway (GO:0007215)3.61695406
69CENP-A containing nucleosome assembly (GO:0034080)3.59016422
70gamma-aminobutyric acid transport (GO:0015812)3.57450130
71regulation of spindle organization (GO:0090224)3.56126024
72gene silencing (GO:0016458)3.56066503
73reflex (GO:0060004)3.55311050
74male meiosis (GO:0007140)3.54703756
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54282263
76neurotransmitter uptake (GO:0001504)3.51473419
77regulation of histone methylation (GO:0031060)3.51167711
78negative regulation of hormone biosynthetic process (GO:0032353)3.50665627
79labyrinthine layer development (GO:0060711)3.47458678
80synaptonemal complex assembly (GO:0007130)3.43438192
81negative regulation of neurotransmitter transport (GO:0051589)3.42402141
82fertilization (GO:0009566)3.41785932
83negative regulation of hormone metabolic process (GO:0032351)3.40253825
84myelination (GO:0042552)3.39999518
85oogenesis (GO:0048477)3.39736009
86cellular response to pH (GO:0071467)3.39100111
87regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38522382
88meiosis I (GO:0007127)3.37735367
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.37686913
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.36531114
91gamma-aminobutyric acid signaling pathway (GO:0007214)3.34962732
92regulation of calcium ion-dependent exocytosis (GO:0017158)3.34489304
93regulation of female receptivity (GO:0045924)3.32662071
94regulation of meiotic cell cycle (GO:0051445)3.31893006
95axon ensheathment (GO:0008366)3.30989075
96ensheathment of neurons (GO:0007272)3.30989075
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30453220
98binding of sperm to zona pellucida (GO:0007339)3.30336550
99aggressive behavior (GO:0002118)3.29153346
100chromosome organization involved in meiosis (GO:0070192)3.29018834
101cellular potassium ion homeostasis (GO:0030007)3.28931723
102regulation of reproductive process (GO:2000241)3.27989651
103cerebral cortex radially oriented cell migration (GO:0021799)3.26912324
104regulation of spindle checkpoint (GO:0090231)3.25503613
105neuron recognition (GO:0008038)3.24901621
106protein localization to chromosome (GO:0034502)3.24435408
107microtubule severing (GO:0051013)3.24398086
108vocalization behavior (GO:0071625)3.24075727
109chromatin remodeling at centromere (GO:0031055)3.23974501
110regulation of uterine smooth muscle contraction (GO:0070472)3.21766362
111eye photoreceptor cell differentiation (GO:0001754)3.20621981
112photoreceptor cell differentiation (GO:0046530)3.20621981
113metaphase plate congression (GO:0051310)3.19201588
114hyperosmotic salinity response (GO:0042538)3.19056546
115cerebellar Purkinje cell differentiation (GO:0021702)3.18773106
116regulation of synaptic vesicle exocytosis (GO:2000300)3.18356137
117translesion synthesis (GO:0019985)3.17973900
118potassium ion homeostasis (GO:0055075)3.17847958
119neurotransmitter secretion (GO:0007269)3.16466147
120meiotic nuclear division (GO:0007126)3.16155968
121adult locomotory behavior (GO:0008344)3.15874722
122potassium ion import (GO:0010107)3.11627163
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.11593501
124negative regulation of cAMP-mediated signaling (GO:0043951)3.10845717
125response to acidic pH (GO:0010447)3.09602974
126positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09299857
127regulation of short-term neuronal synaptic plasticity (GO:0048172)3.08751744
128regulation of respiratory system process (GO:0044065)3.08294137
129synaptic transmission, glutamatergic (GO:0035249)3.07733130
130postsynaptic membrane organization (GO:0001941)3.07537677
131chromatin assembly (GO:0031497)3.06524123
132* neurotransmitter transport (GO:0006836)3.05525510
133regulation of cytokine production involved in inflammatory response (GO:1900015)3.04853756
134* neuron-neuron synaptic transmission (GO:0007270)3.03279133
135positive regulation of meiosis (GO:0045836)3.02950832
136meiotic cell cycle process (GO:1903046)3.01797478
137DNA damage induced protein phosphorylation (GO:0006975)3.01729664
138N-terminal protein amino acid acetylation (GO:0006474)3.00981771
139negative regulation of protein localization to cell surface (GO:2000009)3.00193441
140synaptonemal complex organization (GO:0070193)2.98534550
141negative regulation of neurotransmitter secretion (GO:0046929)2.98139322
142single fertilization (GO:0007338)2.97754460
143cerebellar granule cell differentiation (GO:0021707)2.97475861
144stress granule assembly (GO:0034063)2.96954826
145synaptic vesicle maturation (GO:0016188)2.96812478
146neuronal ion channel clustering (GO:0045161)2.95592839
147positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94947285
148DNA replication-dependent nucleosome organization (GO:0034723)2.94875107
149DNA replication-dependent nucleosome assembly (GO:0006335)2.94875107
150synaptic vesicle exocytosis (GO:0016079)2.94872230
151* amino acid import (GO:0043090)2.94851028
152histone H3-K9 demethylation (GO:0033169)2.94494806
153protein localization to synapse (GO:0035418)2.94420762
154* glycine transport (GO:0015816)2.93723509
155neuron remodeling (GO:0016322)2.92878517
156somite rostral/caudal axis specification (GO:0032525)2.89193456
157limb bud formation (GO:0060174)2.88321506
158regulation of synaptic vesicle transport (GO:1902803)2.87482251
159positive regulation of meiotic cell cycle (GO:0051446)2.85843283
160regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.83139079
161regulation of respiratory gaseous exchange (GO:0043576)2.81074646
162regulation of glutamate receptor signaling pathway (GO:1900449)2.80866509
163positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74488903
164membrane hyperpolarization (GO:0060081)2.74306834
165adult behavior (GO:0030534)2.72659054
166regulation of neurotransmitter levels (GO:0001505)2.72453406
167axonal fasciculation (GO:0007413)2.72285907
168locomotory exploration behavior (GO:0035641)2.69798970
169oligodendrocyte differentiation (GO:0048709)2.67628234
170glutamate secretion (GO:0014047)2.66563231
171positive regulation of potassium ion transmembrane transport (GO:1901381)2.65940907
172positive regulation of synapse assembly (GO:0051965)2.65630642
173cell differentiation in hindbrain (GO:0021533)2.63400537
174positive regulation of action potential (GO:0045760)2.61692114
175regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.61596666
176positive regulation of potassium ion transport (GO:0043268)2.61232052
177neuromuscular synaptic transmission (GO:0007274)2.60237598
178long-term memory (GO:0007616)2.58190581
179synaptic vesicle endocytosis (GO:0048488)2.56173625
180retina layer formation (GO:0010842)2.53879358
181regulation of neurotransmitter secretion (GO:0046928)2.52128384
182positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.51101398
183regulation of neurotransmitter transport (GO:0051588)2.49790291
184detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.49186086
185cranial nerve development (GO:0021545)2.45453752
186regulation of vesicle fusion (GO:0031338)2.44747011
187acrosome reaction (GO:0007340)2.44311750
188locomotory behavior (GO:0007626)2.43842701
189regulation of neurotransmitter uptake (GO:0051580)2.43506393
190potassium ion transmembrane transport (GO:0071805)2.42679875
191cellular potassium ion transport (GO:0071804)2.42679875
192long-term synaptic potentiation (GO:0060291)2.42158824
193cranial nerve structural organization (GO:0021604)2.42099202
194regulation of timing of cell differentiation (GO:0048505)2.41186402
195fatty acid elongation (GO:0030497)2.40610843
196dendrite morphogenesis (GO:0048813)2.39615467
197regulation of collateral sprouting (GO:0048670)2.38890711
198response to auditory stimulus (GO:0010996)2.38784361
199regulation of DNA methylation (GO:0044030)10.7645379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.38663834
2GBX2_23144817_ChIP-Seq_PC3_Human3.82035219
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.80312384
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.80312384
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.80312384
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08892900
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.02108828
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.98944224
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.95024653
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84642457
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74730626
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69389397
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.60243338
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54589196
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48254626
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48254626
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.47990235
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38393651
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35221492
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34313215
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32752424
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12884051
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11280292
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11210803
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07786601
26TAF15_26573619_Chip-Seq_HEK293_Human2.06873768
27GATA1_26923725_Chip-Seq_HPCs_Mouse2.06787643
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05117276
29CBX2_27304074_Chip-Seq_ESCs_Mouse2.02739015
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98513715
31DROSHA_22980978_ChIP-Seq_HELA_Human1.95404589
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93145870
33* RNF2_27304074_Chip-Seq_ESCs_Mouse1.92641441
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92108140
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.90612700
36AR_21572438_ChIP-Seq_LNCaP_Human1.84843579
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83667388
38* REST_21632747_ChIP-Seq_MESCs_Mouse1.80657624
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80488105
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75532740
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.75248936
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74799889
43E2F7_22180533_ChIP-Seq_HELA_Human1.73893721
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72050483
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68777487
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.66548278
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66520820
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64412123
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63378195
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61680249
51P300_19829295_ChIP-Seq_ESCs_Human1.59002457
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.55881337
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55722496
54SMAD4_21799915_ChIP-Seq_A2780_Human1.55438374
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55133241
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54797917
57RNF2_27304074_Chip-Seq_NSC_Mouse1.53702217
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53659980
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.50595567
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46042692
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.45824362
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43685086
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.42424407
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42137496
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41047544
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.40412950
67VDR_22108803_ChIP-Seq_LS180_Human1.39663792
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38846819
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.35910974
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35851864
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33391575
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32960873
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.30983413
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30763970
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29861057
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.29597326
77ER_23166858_ChIP-Seq_MCF-7_Human1.29297319
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.28531128
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28309062
80STAT3_23295773_ChIP-Seq_U87_Human1.27769506
81P53_22387025_ChIP-Seq_ESCs_Mouse1.27680577
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26586329
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25747809
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25372638
85IGF1R_20145208_ChIP-Seq_DFB_Human1.25049050
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.24655361
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23849870
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23364044
89* REST_18959480_ChIP-ChIP_MESCs_Mouse1.23102056
90IRF1_19129219_ChIP-ChIP_H3396_Human1.22868112
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.22834957
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20150036
93ZNF274_21170338_ChIP-Seq_K562_Hela1.19923213
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.19208263
95* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18850774
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.18633889
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18382163
98P300_18555785_Chip-Seq_ESCs_Mouse1.17716359
99* RING1B_27294783_Chip-Seq_ESCs_Mouse1.17049703
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16688890
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16688890
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15892978
103CBP_20019798_ChIP-Seq_JUKART_Human1.15892978
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15696707
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.14261469
106RUNX2_22187159_ChIP-Seq_PCA_Human1.11744489
107FUS_26573619_Chip-Seq_HEK293_Human1.11556574
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11297972
109NMYC_18555785_Chip-Seq_ESCs_Mouse1.11234977
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11108014
111AR_25329375_ChIP-Seq_VCAP_Human1.10970744
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09838938
113TCF4_23295773_ChIP-Seq_U87_Human1.09749896
114SOX2_18555785_Chip-Seq_ESCs_Mouse1.09708279
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.09040184
116TP53_18474530_ChIP-ChIP_U2OS_Human1.07111436
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06877170
118PU1_27457419_Chip-Seq_LIVER_Mouse1.04706188
119KLF4_18555785_Chip-Seq_ESCs_Mouse1.04099127
120OCT4_18555785_Chip-Seq_ESCs_Mouse1.03331576
121AHR_22903824_ChIP-Seq_MCF-7_Human1.02760585
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02732854
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02104331
124GF1_26923725_Chip-Seq_HPCs_Mouse1.01326908
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00878463
126* RING1B_27294783_Chip-Seq_NPCs_Mouse1.00275898
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99780988
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99651778
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99413120
130CTCF_18555785_Chip-Seq_ESCs_Mouse0.99109491
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.98357560
132SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96694856
133NANOG_20526341_ChIP-Seq_ESCs_Human0.94738483
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92857020
135TAL1_26923725_Chip-Seq_HPCs_Mouse0.91183233
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88002364
137EWS_26573619_Chip-Seq_HEK293_Human0.87601208
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86697022
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86587457
140* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83621063
141ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83368748
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79931127
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78383443
144GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77680414
145KDM2B_26808549_Chip-Seq_REH_Human0.76752972
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.75879467
147E2F4_17652178_ChIP-ChIP_JURKAT_Human0.75459931
148LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74941975
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.74819206
150TP53_22573176_ChIP-Seq_HFKS_Human0.74750620
151BCAT_22108803_ChIP-Seq_LS180_Human0.72983941
152SALL1_21062744_ChIP-ChIP_HESCs_Human0.72300941
153* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.71489043
154KLF4_19829295_ChIP-Seq_ESCs_Human0.70179587
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.69521622
156SALL4_22934838_ChIP-ChIP_CD34+_Human0.69356398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.50035426
2MP0003880_abnormal_central_pattern5.30024425
3MP0008877_abnormal_DNA_methylation4.06990866
4MP0008789_abnormal_olfactory_epithelium4.00558524
5MP0009046_muscle_twitch3.18439967
6MP0004859_abnormal_synaptic_plasticity3.14909053
7MP0005423_abnormal_somatic_nervous3.06971428
8MP0005395_other_phenotype2.93720195
9* MP0001486_abnormal_startle_reflex2.86905747
10* MP0003635_abnormal_synaptic_transmissio2.84211405
11MP0002138_abnormal_hepatobiliary_system2.76277653
12MP0009745_abnormal_behavioral_response2.75769891
13MP0010234_abnormal_vibrissa_follicle2.72650448
14MP0002064_seizures2.72643297
15MP0002102_abnormal_ear_morphology2.72014341
16MP0002272_abnormal_nervous_system2.69338247
17MP0003890_abnormal_embryonic-extraembry2.64169261
18MP0005360_urolithiasis2.56824457
19MP0008057_abnormal_DNA_replication2.53323612
20MP0002139_abnormal_hepatobiliary_system2.53284037
21MP0004742_abnormal_vestibular_system2.41448753
22MP0003693_abnormal_embryo_hatching2.38387197
23MP0001188_hyperpigmentation2.35929845
24MP0000920_abnormal_myelination2.29178588
25MP0001501_abnormal_sleep_pattern2.28319406
26MP0005171_absent_coat_pigmentation2.21895356
27MP0003699_abnormal_female_reproductive2.20681669
28MP0001440_abnormal_grooming_behavior2.19213609
29MP0004270_analgesia2.18553039
30MP0003136_yellow_coat_color2.17639314
31MP0010030_abnormal_orbit_morphology2.15568585
32* MP0004142_abnormal_muscle_tone2.15055377
33* MP0002067_abnormal_sensory_capabilities2.14028606
34MP0001968_abnormal_touch/_nociception2.10531568
35MP0003690_abnormal_glial_cell2.04951509
36MP0001929_abnormal_gametogenesis2.04020953
37MP0008569_lethality_at_weaning2.03811324
38MP0000566_synostosis2.03051718
39MP0002734_abnormal_mechanical_nocicepti2.01863272
40MP0002063_abnormal_learning/memory/cond2.00286961
41MP0002572_abnormal_emotion/affect_behav1.99638612
42MP0002210_abnormal_sex_determination1.97169450
43MP0004885_abnormal_endolymph1.96066205
44MP0005646_abnormal_pituitary_gland1.95521441
45MP0002234_abnormal_pharynx_morphology1.95037262
46MP0003183_abnormal_peptide_metabolism1.93293323
47MP0000778_abnormal_nervous_system1.89551902
48MP0005551_abnormal_eye_electrophysiolog1.77774048
49MP0002736_abnormal_nociception_after1.76733123
50MP0002735_abnormal_chemical_nociception1.74654044
51MP0001485_abnormal_pinna_reflex1.72376403
52MP0003077_abnormal_cell_cycle1.67366010
53MP0002184_abnormal_innervation1.65673820
54MP0006276_abnormal_autonomic_nervous1.65144897
55MP0001970_abnormal_pain_threshold1.65130196
56MP0003787_abnormal_imprinting1.62636522
57MP0005645_abnormal_hypothalamus_physiol1.61842329
58MP0000955_abnormal_spinal_cord1.58028393
59MP0002161_abnormal_fertility/fecundity1.55599196
60MP0001963_abnormal_hearing_physiology1.53833535
61MP0003121_genomic_imprinting1.53705632
62MP0002557_abnormal_social/conspecific_i1.52260303
63MP0000653_abnormal_sex_gland1.50648364
64MP0004381_abnormal_hair_follicle1.49935322
65MP0002733_abnormal_thermal_nociception1.49576481
66MP0006292_abnormal_olfactory_placode1.48147696
67MP0002160_abnormal_reproductive_system1.47701845
68MP0001502_abnormal_circadian_rhythm1.40117393
69MP0002882_abnormal_neuron_morphology1.36827291
70MP0006072_abnormal_retinal_apoptosis1.36489498
71MP0005409_darkened_coat_color1.35727129
72MP0008058_abnormal_DNA_repair1.34447117
73MP0000026_abnormal_inner_ear1.32140173
74MP0001905_abnormal_dopamine_level1.30909000
75MP0002229_neurodegeneration1.30085116
76MP0001324_abnormal_eye_pigmentation1.29174211
77MP0003634_abnormal_glial_cell1.28419818
78* MP0002066_abnormal_motor_capabilities/c1.28303607
79MP0002752_abnormal_somatic_nervous1.28075375
80MP0005623_abnormal_meninges_morphology1.27886365
81MP0004924_abnormal_behavior1.26424217
82MP0005386_behavior/neurological_phenoty1.26424217
83MP0010094_abnormal_chromosome_stability1.24776452
84MP0005253_abnormal_eye_physiology1.22670428
85MP0009379_abnormal_foot_pigmentation1.21383367
86MP0001529_abnormal_vocalization1.21304715
87MP0001145_abnormal_male_reproductive1.20311250
88MP0003698_abnormal_male_reproductive1.19385329
89MP0003938_abnormal_ear_development1.18638586
90MP0003111_abnormal_nucleus_morphology1.18141975
91MP0001293_anophthalmia1.17969446
92MP0003633_abnormal_nervous_system1.13734315
93MP0010307_abnormal_tumor_latency1.12170974
94MP0001730_embryonic_growth_arrest1.10474436
95MP0005410_abnormal_fertilization1.10066951
96MP0002233_abnormal_nose_morphology1.07590207
97MP0001984_abnormal_olfaction1.05921724
98MP0008260_abnormal_autophagy1.05886988
99MP0001119_abnormal_female_reproductive1.05380525
100MP0003631_nervous_system_phenotype1.04870403
101MP0003119_abnormal_digestive_system1.04568748
102MP0005503_abnormal_tendon_morphology1.04512548
103MP0008932_abnormal_embryonic_tissue1.02790360
104MP0005647_abnormal_sex_gland1.02557712
105MP0004145_abnormal_muscle_electrophysio1.02185224
106MP0003252_abnormal_bile_duct1.00454090
107MP0003329_amyloid_beta_deposits0.99285288
108MP0000427_abnormal_hair_cycle0.97802927
109MP0003632_abnormal_nervous_system0.96668837
110MP0010368_abnormal_lymphatic_system0.94902083
111MP0003385_abnormal_body_wall0.94321790
112MP0001346_abnormal_lacrimal_gland0.93236658
113MP0009840_abnormal_foam_cell0.91406589
114MP0010386_abnormal_urinary_bladder0.91277481
115MP0002638_abnormal_pupillary_reflex0.90684477
116MP0005389_reproductive_system_phenotype0.90675789
117MP0002249_abnormal_larynx_morphology0.89226968
118MP0004811_abnormal_neuron_physiology0.88781073
119MP0003868_abnormal_feces_composition0.88689926
120MP0002876_abnormal_thyroid_physiology0.88150595
121MP0000631_abnormal_neuroendocrine_gland0.87445672
122MP0002152_abnormal_brain_morphology0.86201960
123MP0002277_abnormal_respiratory_mucosa0.86063071
124MP0004147_increased_porphyrin_level0.83737548
125MP0004134_abnormal_chest_morphology0.80608414
126MP0001177_atelectasis0.79978721
127MP0004043_abnormal_pH_regulation0.79904968
128MP0010678_abnormal_skin_adnexa0.78448891
129MP0003879_abnormal_hair_cell0.76064013
130MP0001672_abnormal_embryogenesis/_devel0.75335551
131MP0005380_embryogenesis_phenotype0.75335551
132MP0000383_abnormal_hair_follicle0.74950096
133MP0001664_abnormal_digestion0.74780059
134MP0005085_abnormal_gallbladder_physiolo0.72383547
135MP0003122_maternal_imprinting0.72278862
136MP0001299_abnormal_eye_distance/0.71400699
137MP0000049_abnormal_middle_ear0.71371583
138MP0004484_altered_response_of0.71132049
139MP0003195_calcinosis0.70217819
140MP0000015_abnormal_ear_pigmentation0.69474566
141MP0003950_abnormal_plasma_membrane0.67646535
142MP0009780_abnormal_chondrocyte_physiolo0.67368180
143MP0001986_abnormal_taste_sensitivity0.66914899
144MP0005195_abnormal_posterior_eye0.65226692
145MP0000462_abnormal_digestive_system0.63957588
146MP0000350_abnormal_cell_proliferation0.63542466
147MP0002127_abnormal_cardiovascular_syste0.63180894
148MP0009250_abnormal_appendicular_skeleto0.63164681
149MP0003137_abnormal_impulse_conducting0.59602097
150MP0005174_abnormal_tail_pigmentation0.59370551
151MP0003755_abnormal_palate_morphology0.58946535
152MP0000579_abnormal_nail_morphology0.58053625
153MP0003861_abnormal_nervous_system0.57435396
154MP0005394_taste/olfaction_phenotype0.57418019
155MP0005499_abnormal_olfactory_system0.57418019
156MP0000762_abnormal_tongue_morphology0.55865935
157MP0001666_abnormal_nutrient_absorption0.55169437
158MP0001286_abnormal_eye_development0.54714561
159MP0002084_abnormal_developmental_patter0.52926979
160MP0003935_abnormal_craniofacial_develop0.51420257
161MP0001881_abnormal_mammary_gland0.50853288
162MP0002796_impaired_skin_barrier0.45676697

Predicted human phenotypes

RankGene SetZ-score
1Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)6.03737000
2Focal motor seizures (HP:0011153)5.51166621
3Supernumerary spleens (HP:0009799)5.41287126
4Abnormality of abdominal situs (HP:0011620)5.15738813
5Abdominal situs inversus (HP:0003363)5.15738813
6Osteomalacia (HP:0002749)4.80023338
7Male infertility (HP:0003251)4.75655064
8Facial hemangioma (HP:0000329)4.55584285
9Supranuclear gaze palsy (HP:0000605)4.50077124
10Impulsivity (HP:0100710)4.14576291
11Hypoplasia of the fovea (HP:0007750)4.13552266
12Aplasia/Hypoplasia of the fovea (HP:0008060)4.13552266
13Lip pit (HP:0100267)4.04262019
14Hypophosphatemic rickets (HP:0004912)4.04135213
15Febrile seizures (HP:0002373)4.02084447
16Cholecystitis (HP:0001082)4.01528900
17Abnormal gallbladder physiology (HP:0012438)4.01528900
18Anterior segment dysgenesis (HP:0007700)3.98327728
19Lower limb hyperreflexia (HP:0002395)3.81821120
20Papillary thyroid carcinoma (HP:0002895)3.63968082
21Progressive cerebellar ataxia (HP:0002073)3.61002397
22Infertility (HP:0000789)3.60131876
23Peripheral hypomyelination (HP:0007182)3.55644489
24Malnutrition (HP:0004395)3.47417492
25Azoospermia (HP:0000027)3.47392277
26Increased circulating renin level (HP:0000848)3.46164559
27Abnormality of the fovea (HP:0000493)3.44158363
28Atonic seizures (HP:0010819)3.43673660
29Premature ovarian failure (HP:0008209)3.42319830
30Median cleft lip (HP:0000161)3.36516674
31Focal seizures (HP:0007359)3.33769785
32Split foot (HP:0001839)3.22472692
33Apathy (HP:0000741)3.21020277
34Slow saccadic eye movements (HP:0000514)3.20688625
35Epileptic encephalopathy (HP:0200134)3.18056285
36Parakeratosis (HP:0001036)3.11040855
37Abnormality of the labia minora (HP:0012880)3.10196584
38Myokymia (HP:0002411)3.08823096
39Dynein arm defect of respiratory motile cilia (HP:0012255)3.07923268
40Absent/shortened dynein arms (HP:0200106)3.07923268
41Diminished motivation (HP:0000745)3.07284840
42Degeneration of the lateral corticospinal tracts (HP:0002314)3.06973095
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.06973095
44Gonadotropin excess (HP:0000837)2.97191169
45Short tibia (HP:0005736)2.95992249
46Aplasia involving bones of the upper limbs (HP:0009823)2.94321741
47Aplasia of the phalanges of the hand (HP:0009802)2.94321741
48Aplasia involving bones of the extremities (HP:0009825)2.94321741
49Septo-optic dysplasia (HP:0100842)2.90109871
50Generalized tonic-clonic seizures (HP:0002069)2.87275150
51Hypokinesia (HP:0002375)2.79057204
52Enlarged penis (HP:0000040)2.77766396
53Metabolic alkalosis (HP:0200114)2.76176729
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.75954981
55Neurofibrillary tangles (HP:0002185)2.74323774
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.74194567
57Dysdiadochokinesis (HP:0002075)2.70986984
58Action tremor (HP:0002345)2.69432800
59Abnormal ciliary motility (HP:0012262)2.67466021
60Oligodactyly (hands) (HP:0001180)2.64666823
61Dysmetria (HP:0001310)2.63826837
62Alacrima (HP:0000522)2.62831952
63White forelock (HP:0002211)2.61893306
64Oligodactyly (HP:0012165)2.60057675
65Aplasia cutis congenita (HP:0001057)2.59738903
66Gaze-evoked nystagmus (HP:0000640)2.59512375
67Chromsome breakage (HP:0040012)2.58243414
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57762374
69Aplasia of the musculature (HP:0100854)2.55142249
70Visual hallucinations (HP:0002367)2.54541664
71Hemiparesis (HP:0001269)2.54505446
72Urethral obstruction (HP:0000796)2.54059888
73Hypomagnesemia (HP:0002917)2.53490354
74Abnormality of the corticospinal tract (HP:0002492)2.52623450
75Truncal obesity (HP:0001956)2.51205848
76Aplasia/Hypoplasia of the macula (HP:0008059)2.49698090
77Onion bulb formation (HP:0003383)2.47214808
78Wrist flexion contracture (HP:0001239)2.46165792
79Abnormal spermatogenesis (HP:0008669)2.45876021
80Dialeptic seizures (HP:0011146)2.43290482
81Retinal dysplasia (HP:0007973)2.42569480
82Patchy hypopigmentation of hair (HP:0011365)2.41897957
83Skin pits (HP:0100276)2.41425797
84Absence seizures (HP:0002121)2.40958746
85Capillary hemangiomas (HP:0005306)2.40002510
86Intention tremor (HP:0002080)2.37914890
87Proximal tubulopathy (HP:0000114)2.35591100
88Progressive inability to walk (HP:0002505)2.34686823
89Ankle clonus (HP:0011448)2.34500755
90Striae distensae (HP:0001065)2.34375403
91Abnormal respiratory motile cilium physiology (HP:0012261)2.31653709
92Spinal cord compression (HP:0002176)2.30944707
93Humeroradial synostosis (HP:0003041)2.30913436
94Synostosis involving the elbow (HP:0003938)2.30913436
95Aplasia/Hypoplasia affecting the retina (HP:0008061)2.28063541
96Conjunctival telangiectasia (HP:0000524)2.27308197
97Abnormality of macular pigmentation (HP:0008002)2.27192483
98Absent septum pellucidum (HP:0001331)2.24339407
99Hyperventilation (HP:0002883)2.23141430
100Decreased lacrimation (HP:0000633)2.21290597
101Bundle branch block (HP:0011710)2.21254718
102Loss of speech (HP:0002371)2.19579345
103Abnormality of chromosome segregation (HP:0002916)2.19342794
104Aplasia/Hypoplasia of the tongue (HP:0010295)2.18873054
105Fair hair (HP:0002286)2.15770142
106Bicornuate uterus (HP:0000813)2.15396088
107Abnormality of binocular vision (HP:0011514)2.15027882
108Diplopia (HP:0000651)2.15027882
109Optic nerve hypoplasia (HP:0000609)2.14436361
110Broad-based gait (HP:0002136)2.14325326
111Midline defect of the nose (HP:0004122)2.14224118
112Anhidrosis (HP:0000970)2.13565400
113Decreased central vision (HP:0007663)2.13152705
114Morphological abnormality of the inner ear (HP:0011390)2.12273773
115Conical tooth (HP:0000698)2.11623934
116Absent speech (HP:0001344)2.11170995
117Intrahepatic cholestasis (HP:0001406)2.06911408
118Maternal diabetes (HP:0009800)2.06910885
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05831928
120Scanning speech (HP:0002168)2.02438865
121Spastic gait (HP:0002064)2.02422053
122Decreased circulating renin level (HP:0003351)2.01328875
123Congenital stationary night blindness (HP:0007642)2.00847228
124Abnormality of the middle phalanges of the toes (HP:0010183)2.00525936
125Fetal akinesia sequence (HP:0001989)2.00217595
126Abnormal eating behavior (HP:0100738)2.00170197
127Abnormality of saccadic eye movements (HP:0000570)1.99219937
128Thyroid carcinoma (HP:0002890)1.99145812
129Abnormality of the septum pellucidum (HP:0007375)1.98107060
130Abnormal drinking behavior (HP:0030082)1.97786162
131Polydipsia (HP:0001959)1.97786162
132Spastic paraplegia (HP:0001258)1.97330501
133Congenital sensorineural hearing impairment (HP:0008527)1.96931211
134Abnormal respiratory epithelium morphology (HP:0012253)1.96636386
135Abnormal respiratory motile cilium morphology (HP:0005938)1.96636386
136Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.96371161
137Abnormal biliary tract physiology (HP:0012439)1.95045879
138Bile duct proliferation (HP:0001408)1.95045879
139Hypercortisolism (HP:0001578)1.93872236
140Nasolacrimal duct obstruction (HP:0000579)1.93351064
141Thickened helices (HP:0000391)1.93342169
142Mixed hearing impairment (HP:0000410)1.93334645
143Paraplegia (HP:0010550)1.93101489
144Molar tooth sign on MRI (HP:0002419)1.91516798
145Abnormality of midbrain morphology (HP:0002418)1.91516798
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.91108847
147Abnormality of renin-angiotensin system (HP:0000847)1.90999991
148Dysmetric saccades (HP:0000641)1.89347508
149Metaphyseal irregularity (HP:0003025)1.88715026
150Generalized aminoaciduria (HP:0002909)1.88382984
151Stillbirth (HP:0003826)1.86657763
152Abnormality of magnesium homeostasis (HP:0004921)1.86352925
153Heterotopia (HP:0002282)1.86085458
154Akinesia (HP:0002304)1.85761793
155Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85389964
156Limb dystonia (HP:0002451)1.83978902
157Abnormality of the phalanges of the hallux (HP:0010057)1.83769617
158Postural instability (HP:0002172)1.83689931
159Severe visual impairment (HP:0001141)1.83478736
160Upper limb muscle weakness (HP:0003484)1.82392932
161Blue irides (HP:0000635)1.82053178
162Drooling (HP:0002307)1.78777761
163Excessive salivation (HP:0003781)1.78777761
164Anxiety (HP:0000739)1.78760648
165Abnormality of incisor morphology (HP:0011063)1.77515586
166Hemiplegia (HP:0002301)1.77411002
167Generalized myoclonic seizures (HP:0002123)1.77228595
168Hypohidrosis (HP:0000966)1.76632760
169Preauricular pit (HP:0004467)1.76449067
170Periauricular skin pits (HP:0100277)1.76449067
171Sensory axonal neuropathy (HP:0003390)1.75830262
172Abnormal lung lobation (HP:0002101)1.74254417
173Cranial hyperostosis (HP:0004437)1.73960097
174Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72067558
175Rhinitis (HP:0012384)1.71975747
176Duplication of thumb phalanx (HP:0009942)1.70333875
177Abnormality of calcium-phosphate metabolism (HP:0100530)1.70218375
178Esotropia (HP:0000565)1.70023209
179Hip contracture (HP:0003273)1.69291364
180Tubulointerstitial nephritis (HP:0001970)1.68827564
181Retinal atrophy (HP:0001105)1.67848601
182Deep palmar crease (HP:0006191)1.66743245
183Posterior subcapsular cataract (HP:0007787)1.65623093
184Abnormality of the anterior chamber (HP:0000593)1.64217648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF6.56509199
2CASK4.29207515
3WNK13.06253354
4BRAF2.92381796
5NTRK32.87611837
6MOS2.83125253
7STK392.77098810
8TNIK2.66569418
9MAP2K72.58379524
10STK242.50878694
11KSR22.46850394
12OXSR12.43036981
13TAOK32.39594247
14MAP3K42.24300540
15BLK2.20060668
16RAF12.16126480
17MARK11.95328980
18TTK1.89885592
19UHMK11.87990851
20MET1.82975684
21PKN11.79766615
22AURKA1.79352854
23CDK191.78811475
24TNK21.73680275
25MAPK131.63357926
26NEK61.61339733
27PNCK1.58151454
28KSR11.57060169
29MAP3K121.52395981
30TRIM281.50336921
31PAK61.49823708
32CDK91.49815131
33SGK2231.48915144
34SGK4941.48915144
35PINK11.48479897
36PRKCI1.47017922
37INSRR1.45252303
38MUSK1.39013133
39CDC71.36860539
40NTRK21.33225459
41GRK71.31342114
42MINK11.30705010
43GRK11.28110841
44MKNK21.24529087
45MAP2K41.22737030
46FES1.21237841
47PRPF4B1.20364970
48EPHA41.20138115
49CAMK2B1.19507942
50PLK21.18625301
51ROCK21.17678151
52WNK41.17183280
53ADRBK21.12987478
54CDK121.12357445
55BMPR21.12041748
56PLK11.10947435
57STK381.09993416
58CDK71.09633258
59PRKCE1.09116767
60STK161.08202472
61CAMK2G1.06511432
62PRKCG1.05768419
63MAPKAPK51.05029658
64EIF2AK31.04796251
65LIMK11.03909521
66PHKG21.01540913
67PHKG11.01540913
68NEK21.01301633
69MELK1.00108314
70GRK50.98039355
71BCR0.96920473
72TYRO30.94869352
73CAMK2A0.94675927
74STK30.94576945
75CAMK2D0.94061687
76RIPK40.92613400
77MAP3K130.90794441
78IRAK20.86907504
79BMPR1B0.86292915
80BUB10.86153262
81CDK50.84206774
82BRSK10.81016498
83ZAK0.79562576
84PIM10.78402675
85MAP3K80.76129894
86CDK30.75817057
87STK110.75181019
88EIF2AK20.73103741
89DYRK1A0.73072862
90YES10.72591055
91SGK20.71933768
92PAK30.70530544
93CAMKK10.69997403
94FGR0.69674745
95BRD40.69423459
96EPHB10.69184380
97PTK20.69151960
98SGK10.68319597
99CDC42BPA0.67791128
100MAP3K140.67774065
101NTRK10.66923833
102AKT30.66057385
103CHEK10.63513650
104MAP3K90.63176236
105PRKCH0.61828849
106IRAK10.61029565
107SIK20.60750314
108CDK20.59927464
109PRKCQ0.58918171
110TIE10.58567178
111CSNK1D0.57578125
112CAMK1G0.57331012
113LATS20.56473081
114PRKG10.55719692
115CSNK1E0.55550654
116PLK30.55432677
117CAMK10.55313839
118CSNK1A1L0.55169199
119CSNK1G10.53914221
120PRKCZ0.51469212
121PBK0.50977246
122PRKD10.50408200
123CSNK1G20.49137933
124EEF2K0.48524631
125PRKACA0.46867751
126PAK10.46610470
127MARK30.46097851
128MARK20.45426521
129AURKB0.44449704
130MAPK100.44386087
131FER0.43964968
132ROCK10.43812180
133CHEK20.43726126
134MKNK10.42080503
135NUAK10.42007948
136DYRK20.41968261
137CDK10.41445497
138SRPK10.41340496
139MAPK70.40038182
140FYN0.39969848
141LMTK20.39960560
142MAPK150.38940612
143MAP3K50.38459243
144ATM0.38442578
145MAPKAPK30.38349214
146CAMKK20.38348228
147DMPK0.37670651
148NEK90.37552089
149MTOR0.37480330
150ADRBK10.37386979
151PRKG20.37375440
152SIK30.36984099
153FGFR20.36801901
154CDK80.34902982
155CDK11A0.33935026
156TGFBR10.32817019
157ATR0.32354640
158LRRK20.31685715
159BRSK20.31569267
160CSNK1G30.31339863
161PRKACB0.30139995
162PDK10.28732205
163CDK150.28674903
164GSK3B0.28491757
165CDK180.23625941
166CSNK2A20.21424362
167MAP2K10.19143332
168MAPK10.17571640
169AKT20.17368683
170VRK10.16156137
171CDK140.15880565

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030225.30890901
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.00959829
3Nicotine addiction_Homo sapiens_hsa050333.97939614
4Cell cycle_Homo sapiens_hsa041103.83703448
5Oocyte meiosis_Homo sapiens_hsa041143.24228936
6Caffeine metabolism_Homo sapiens_hsa002323.00188972
7Mismatch repair_Homo sapiens_hsa034302.71455000
8GABAergic synapse_Homo sapiens_hsa047272.54686546
9Synaptic vesicle cycle_Homo sapiens_hsa047212.53472388
10Glutamatergic synapse_Homo sapiens_hsa047242.46070350
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44707626
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.42849875
13Morphine addiction_Homo sapiens_hsa050322.40797294
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.27190997
15RNA degradation_Homo sapiens_hsa030182.14966147
16Phototransduction_Homo sapiens_hsa047442.11594460
17Base excision repair_Homo sapiens_hsa034102.11415716
18Taste transduction_Homo sapiens_hsa047422.11053982
19Circadian entrainment_Homo sapiens_hsa047132.07285504
20Salivary secretion_Homo sapiens_hsa049702.00031632
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99064608
22Serotonergic synapse_Homo sapiens_hsa047261.89722573
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89127070
24Nucleotide excision repair_Homo sapiens_hsa034201.85272190
25Olfactory transduction_Homo sapiens_hsa047401.80639171
26Fanconi anemia pathway_Homo sapiens_hsa034601.69085481
27Long-term depression_Homo sapiens_hsa047301.68102985
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.66730433
29Gastric acid secretion_Homo sapiens_hsa049711.64767976
30Insulin secretion_Homo sapiens_hsa049111.63229749
31Collecting duct acid secretion_Homo sapiens_hsa049661.59066079
32RNA transport_Homo sapiens_hsa030131.57967744
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57803262
34Axon guidance_Homo sapiens_hsa043601.56743135
35Calcium signaling pathway_Homo sapiens_hsa040201.53996117
36Amphetamine addiction_Homo sapiens_hsa050311.48280169
37p53 signaling pathway_Homo sapiens_hsa041151.47486738
38Ether lipid metabolism_Homo sapiens_hsa005651.43003767
39DNA replication_Homo sapiens_hsa030301.42654165
40Dopaminergic synapse_Homo sapiens_hsa047281.40676563
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36937448
42Long-term potentiation_Homo sapiens_hsa047201.35349316
43cAMP signaling pathway_Homo sapiens_hsa040241.35164504
44Homologous recombination_Homo sapiens_hsa034401.33062875
45Renin secretion_Homo sapiens_hsa049241.32773151
46Cholinergic synapse_Homo sapiens_hsa047251.31149279
47Folate biosynthesis_Homo sapiens_hsa007901.27379908
48Steroid biosynthesis_Homo sapiens_hsa001001.24354765
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23004084
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22167208
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21724171
52mRNA surveillance pathway_Homo sapiens_hsa030151.21443884
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21098558
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18569360
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18244335
56ABC transporters_Homo sapiens_hsa020101.16019283
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13841073
58Sphingolipid metabolism_Homo sapiens_hsa006001.12906886
59Dorso-ventral axis formation_Homo sapiens_hsa043201.12731754
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11124763
61Nitrogen metabolism_Homo sapiens_hsa009101.09922887
62Cocaine addiction_Homo sapiens_hsa050301.08889022
63RNA polymerase_Homo sapiens_hsa030201.08123341
64Oxytocin signaling pathway_Homo sapiens_hsa049211.05868365
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05293524
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02522934
67Fatty acid elongation_Homo sapiens_hsa000620.99645644
68Thyroid cancer_Homo sapiens_hsa052160.99294296
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98326091
70Cardiac muscle contraction_Homo sapiens_hsa042600.96652194
71Rheumatoid arthritis_Homo sapiens_hsa053230.96552598
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.95107632
73Fatty acid biosynthesis_Homo sapiens_hsa000610.94984023
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94971559
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93747527
76Mineral absorption_Homo sapiens_hsa049780.92522892
77Regulation of autophagy_Homo sapiens_hsa041400.92058702
78Pancreatic secretion_Homo sapiens_hsa049720.91393290
79mTOR signaling pathway_Homo sapiens_hsa041500.89197535
80Bile secretion_Homo sapiens_hsa049760.84399329
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82633083
82Ras signaling pathway_Homo sapiens_hsa040140.82497582
83Autoimmune thyroid disease_Homo sapiens_hsa053200.82424333
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80909574
85Ovarian steroidogenesis_Homo sapiens_hsa049130.80690475
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80173901
87Gap junction_Homo sapiens_hsa045400.78567761
88Vibrio cholerae infection_Homo sapiens_hsa051100.78524765
89GnRH signaling pathway_Homo sapiens_hsa049120.78337388
90ErbB signaling pathway_Homo sapiens_hsa040120.77105158
91Inositol phosphate metabolism_Homo sapiens_hsa005620.75325711
92Hedgehog signaling pathway_Homo sapiens_hsa043400.74365792
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70859518
94Choline metabolism in cancer_Homo sapiens_hsa052310.69348877
95Melanogenesis_Homo sapiens_hsa049160.69313314
96MAPK signaling pathway_Homo sapiens_hsa040100.67733174
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.65027462
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63835465
99Type II diabetes mellitus_Homo sapiens_hsa049300.63809172
100Oxidative phosphorylation_Homo sapiens_hsa001900.62986270
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62985945
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.62431441
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62296028
104Phagosome_Homo sapiens_hsa041450.60824741
105Dilated cardiomyopathy_Homo sapiens_hsa054140.59841834
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59558965
107Wnt signaling pathway_Homo sapiens_hsa043100.58183638
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57675105
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56679864
110TGF-beta signaling pathway_Homo sapiens_hsa043500.51566664
111Alzheimers disease_Homo sapiens_hsa050100.47818307
112FoxO signaling pathway_Homo sapiens_hsa040680.46652389
113Arachidonic acid metabolism_Homo sapiens_hsa005900.46411683
114MicroRNAs in cancer_Homo sapiens_hsa052060.45957542
115Melanoma_Homo sapiens_hsa052180.45577888
116Rap1 signaling pathway_Homo sapiens_hsa040150.43890018
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.43857535
118Circadian rhythm_Homo sapiens_hsa047100.41651275
119Linoleic acid metabolism_Homo sapiens_hsa005910.41070547
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40168992
121Histidine metabolism_Homo sapiens_hsa003400.39637139
122Purine metabolism_Homo sapiens_hsa002300.38830662
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38786437
124Graft-versus-host disease_Homo sapiens_hsa053320.38372311
125Hippo signaling pathway_Homo sapiens_hsa043900.37234651
126Viral carcinogenesis_Homo sapiens_hsa052030.37087298
127Arginine and proline metabolism_Homo sapiens_hsa003300.36714071
128Endometrial cancer_Homo sapiens_hsa052130.36690188
129Chemokine signaling pathway_Homo sapiens_hsa040620.36526439
130Estrogen signaling pathway_Homo sapiens_hsa049150.36478149
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36182860
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35264829
133Thyroid hormone synthesis_Homo sapiens_hsa049180.35263915
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35134126
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31325058
136Basal cell carcinoma_Homo sapiens_hsa052170.31192254
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29673169
138Huntingtons disease_Homo sapiens_hsa050160.29256316
139Notch signaling pathway_Homo sapiens_hsa043300.26246870
140Adherens junction_Homo sapiens_hsa045200.26053604
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23351804
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22134624
143Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20611687
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19979877
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.19120631
146Arginine biosynthesis_Homo sapiens_hsa002200.17039007
147Protein digestion and absorption_Homo sapiens_hsa049740.15607683
148Vitamin digestion and absorption_Homo sapiens_hsa049770.15562862

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