SLC6A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in visual perception (GO:0050908)6.65941098
2detection of light stimulus involved in sensory perception (GO:0050962)6.65941098
3retinal cone cell development (GO:0046549)6.42453729
4rhodopsin mediated signaling pathway (GO:0016056)6.27622388
5regulation of rhodopsin mediated signaling pathway (GO:0022400)6.21133113
6detection of molecule of bacterial origin (GO:0032490)5.28874835
7positive regulation of gamma-delta T cell activation (GO:0046645)5.21042408
8retinal rod cell development (GO:0046548)5.12795551
9negative regulation of cell killing (GO:0031342)5.00368987
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.00368987
11response to peptidoglycan (GO:0032494)4.80437759
12photoreceptor cell development (GO:0042461)4.70753422
13neutrophil activation involved in immune response (GO:0002283)4.66683122
14photoreceptor cell maintenance (GO:0045494)4.66228676
15eye photoreceptor cell development (GO:0042462)4.63959756
16cellular extravasation (GO:0045123)4.54080616
17detection of external biotic stimulus (GO:0098581)4.36376279
18detection of other organism (GO:0098543)4.33461676
19negative regulation of interleukin-12 production (GO:0032695)4.27904272
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.27252407
21detection of visible light (GO:0009584)4.16349952
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.12273665
23phototransduction, visible light (GO:0007603)4.04576591
24protein-chromophore linkage (GO:0018298)4.03655564
25detection of light stimulus (GO:0009583)4.00473822
26positive regulation of guanylate cyclase activity (GO:0031284)3.97997688
27phototransduction (GO:0007602)3.94118202
28antigen processing and presentation of endogenous antigen (GO:0019883)3.91963398
29regulation of gamma-delta T cell activation (GO:0046643)3.91209656
30detection of bacterium (GO:0016045)3.85347298
31detection of biotic stimulus (GO:0009595)3.81009104
32negative regulation of erythrocyte differentiation (GO:0045647)3.75430510
33regulation of B cell receptor signaling pathway (GO:0050855)3.72882055
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.71994821
35respiratory burst (GO:0045730)3.67999207
36visual perception (GO:0007601)3.66781189
37regulation of guanylate cyclase activity (GO:0031282)3.64226698
38sensory perception of light stimulus (GO:0050953)3.64034169
39neutrophil activation (GO:0042119)3.58084427
40lipopolysaccharide-mediated signaling pathway (GO:0031663)3.54755096
41regulation of gamma-delta T cell differentiation (GO:0045586)3.50745941
42positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.49954182
43regulation of mast cell degranulation (GO:0043304)3.48604259
44macrophage activation (GO:0042116)3.48051815
45granulocyte activation (GO:0036230)3.46571553
46germinal center formation (GO:0002467)3.46433165
47positive regulation of cellular amide metabolic process (GO:0034250)3.41393556
48regulation of leukocyte degranulation (GO:0043300)3.38034586
49production of molecular mediator involved in inflammatory response (GO:0002532)3.34675534
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.25343594
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.25220344
52microglial cell activation (GO:0001774)3.25132980
53cell adhesion mediated by integrin (GO:0033627)3.24000256
54response to muramyl dipeptide (GO:0032495)3.21740717
55leukocyte aggregation (GO:0070486)3.21075298
56cellular potassium ion homeostasis (GO:0030007)3.20736173
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19904422
58sodium ion export (GO:0071436)3.19753210
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19098492
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.19098492
61modulation by symbiont of host immune response (GO:0052553)3.19098492
62positive regulation by symbiont of host defense response (GO:0052509)3.19098492
63modulation by symbiont of host defense response (GO:0052031)3.19098492
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19098492
65myeloid cell activation involved in immune response (GO:0002275)3.18702657
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17622057
67regulation of mast cell activation involved in immune response (GO:0033006)3.16505111
68response to interleukin-15 (GO:0070672)3.16434984
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15808387
70regulation of T-helper 2 cell differentiation (GO:0045628)3.13966816
71neutrophil mediated immunity (GO:0002446)3.12509013
72eye photoreceptor cell differentiation (GO:0001754)3.11541288
73photoreceptor cell differentiation (GO:0046530)3.11541288
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02224757
75response to host immune response (GO:0052572)3.02224757
76protein localization to endosome (GO:0036010)3.00167332
77positive regulation of mast cell activation (GO:0033005)3.00084463
78leukocyte migration involved in inflammatory response (GO:0002523)2.98534274
79negative regulation of leukocyte mediated immunity (GO:0002704)2.98104429
80immunoglobulin mediated immune response (GO:0016064)2.96531936
81antigen processing and presentation via MHC class Ib (GO:0002475)2.90304165
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90168429
83response to host (GO:0075136)2.88263560
84response to host defenses (GO:0052200)2.88263560
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88263560
86negative regulation of toll-like receptor signaling pathway (GO:0034122)2.87479606
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85711436
88regulation of tolerance induction (GO:0002643)2.85160767
89regulation of regulated secretory pathway (GO:1903305)2.81720502
90regulation of chemokine-mediated signaling pathway (GO:0070099)2.81587036
91regulation of mast cell activation (GO:0033003)2.81031259
92positive regulation of leukocyte degranulation (GO:0043302)2.79255420
93regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.79088224
94detection of external stimulus (GO:0009581)2.76796158
95regulation of cGMP metabolic process (GO:0030823)2.76766774
96neutrophil chemotaxis (GO:0030593)2.76234097
97positive regulation of cGMP biosynthetic process (GO:0030828)2.74829063
98T-helper 1 type immune response (GO:0042088)2.73578108
99B cell receptor signaling pathway (GO:0050853)2.73385499
100negative regulation of T cell mediated immunity (GO:0002710)2.72915312
101regulation of macrophage cytokine production (GO:0010935)2.70508276
102regulation of B cell differentiation (GO:0045577)2.69455998
103neutrophil migration (GO:1990266)2.68790809
104detection of abiotic stimulus (GO:0009582)2.68622887
105negative regulation of type 2 immune response (GO:0002829)2.66968166
106positive regulation of mast cell activation involved in immune response (GO:0033008)2.66471016
107positive regulation of mast cell degranulation (GO:0043306)2.66471016
108import into cell (GO:0098657)2.65185631
109response to laminar fluid shear stress (GO:0034616)2.65098228
110positive regulation of Cdc42 GTPase activity (GO:0043089)2.62618535
111regulation of T cell tolerance induction (GO:0002664)2.62198624
112positive regulation of interferon-alpha production (GO:0032727)2.61822138
113dendritic cell chemotaxis (GO:0002407)2.61659520
114embryonic process involved in female pregnancy (GO:0060136)2.61544041
115regulation of cGMP biosynthetic process (GO:0030826)2.61033937
116potassium ion homeostasis (GO:0055075)2.60836943
117cellular response to light stimulus (GO:0071482)2.60350170
118positive regulation of B cell differentiation (GO:0045579)2.59291886
119peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.59116958
120leukocyte degranulation (GO:0043299)2.57965018
121JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57541542
122dendritic cell migration (GO:0036336)2.57315734
123adhesion of symbiont to host (GO:0044406)2.57225894
124positive regulation of regulated secretory pathway (GO:1903307)2.57194886
125peptidyl-tyrosine autophosphorylation (GO:0038083)2.56918144
126negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.55856976
127negative regulation of T-helper cell differentiation (GO:0045623)2.55856976
128tolerance induction (GO:0002507)2.55180125
129cellular response to type I interferon (GO:0071357)2.55150237
130type I interferon signaling pathway (GO:0060337)2.55150237
131response to lipoprotein particle (GO:0055094)2.55076455
132myeloid leukocyte mediated immunity (GO:0002444)2.54985822
133response to type I interferon (GO:0034340)2.54362666
134positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.53824111
135retina development in camera-type eye (GO:0060041)2.49006970
136macroautophagy (GO:0016236)2.47932675
137positive regulation of cGMP metabolic process (GO:0030825)2.45015415
138regulation of clathrin-mediated endocytosis (GO:2000369)2.43930126
139vascular endothelial growth factor signaling pathway (GO:0038084)2.43756557
140apoptotic cell clearance (GO:0043277)2.43126497
141embryonic retina morphogenesis in camera-type eye (GO:0060059)2.41549813
142lymphangiogenesis (GO:0001946)2.39924542
143iron ion import (GO:0097286)2.39383126
144virion attachment to host cell (GO:0019062)2.39063879
145adhesion of symbiont to host cell (GO:0044650)2.39063879
146positive regulation of p38MAPK cascade (GO:1900745)2.38954047
147retina vasculature morphogenesis in camera-type eye (GO:0061299)2.36651431
148wound healing, spreading of epidermal cells (GO:0035313)2.35729450
149regulation of interferon-beta biosynthetic process (GO:0045357)2.33213719
150potassium ion import (GO:0010107)2.30216584
151hemidesmosome assembly (GO:0031581)2.29284136
152lipoprotein transport (GO:0042953)2.28337307
153negative regulation of fatty acid transport (GO:2000192)2.28210755
154cellular response to vitamin (GO:0071295)2.28041116
155semaphorin-plexin signaling pathway (GO:0071526)2.26667193
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.25288273
157regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.21615991
158relaxation of smooth muscle (GO:0044557)2.20494571
159renal filtration (GO:0097205)2.20480829
160GMP metabolic process (GO:0046037)2.18299918
161macrophage activation involved in immune response (GO:0002281)2.16580348
162lymph vessel development (GO:0001945)2.16529552
163substrate-dependent cell migration (GO:0006929)2.15834634
164cellular response to interferon-alpha (GO:0035457)2.13020797
165regulation of cholesterol storage (GO:0010885)2.12688518
166positive regulation vascular endothelial growth factor production (GO:0010575)2.12055526
167cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.11629616
168negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.11622446
169apical protein localization (GO:0045176)2.11574370
170mannose metabolic process (GO:0006013)2.09690125
171regulation of voltage-gated calcium channel activity (GO:1901385)2.08558337
172regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.06966255
173regulation of p38MAPK cascade (GO:1900744)2.05555311
174axon extension involved in axon guidance (GO:0048846)2.04454930
175neuron projection extension involved in neuron projection guidance (GO:1902284)2.04454930
176positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.04074040
177wound healing, spreading of cells (GO:0044319)2.04012814
178positive regulation of calcium ion import (GO:0090280)2.00289247
179surfactant homeostasis (GO:0043129)2.00188722
180phospholipid translocation (GO:0045332)1.99806762
181lipid translocation (GO:0034204)1.99806762
182response to fluid shear stress (GO:0034405)1.98109585
183antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G1.97329034
184positive regulation of hormone biosynthetic process (GO:0046886)1.96743916
185heparan sulfate proteoglycan biosynthetic process (GO:0015012)1.95951185

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.28429305
2* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19270308
3MYB_21317192_ChIP-Seq_ERMYB_Mouse3.10423841
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.77924401
5* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.72571115
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.71900348
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42931080
8VDR_21846776_ChIP-Seq_THP-1_Human2.41294865
9VDR_24763502_ChIP-Seq_THP-1_Human2.33756582
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28363602
11* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.27332729
12* MYC_22102868_ChIP-Seq_BL_Human2.25608904
13* SPI1_23547873_ChIP-Seq_NB4_Human2.20831424
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.10911791
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07754580
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07291629
17* RUNX1_22412390_ChIP-Seq_EML_Mouse2.06918021
18MAF_26560356_Chip-Seq_TH1_Human2.05181074
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97112134
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95378531
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93958159
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88468014
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86278069
24* SCL_19346495_ChIP-Seq_HPC-7_Human1.85828099
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85538651
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85424739
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.83787033
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83632340
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.82724802
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81457382
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.79254297
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.78026794
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76756523
34* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74458600
35MYB_26560356_Chip-Seq_TH2_Human1.73038118
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72740766
37UTX_26944678_Chip-Seq_JUKART_Human1.70616709
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70192531
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64701640
40DROSHA_22980978_ChIP-Seq_HELA_Human1.61902461
41MYB_26560356_Chip-Seq_TH1_Human1.60608901
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58731449
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58558658
44AHR_22903824_ChIP-Seq_MCF-7_Human1.54202513
45* CLOCK_20551151_ChIP-Seq_293T_Human1.53170532
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.49253527
47GBX2_23144817_ChIP-Seq_PC3_Human1.49197845
48PU_27001747_Chip-Seq_BMDM_Mouse1.49005921
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48508625
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48181419
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46733704
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.46225354
53* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43851168
54* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43231534
55* CJUN_26792858_Chip-Seq_BT549_Human1.41184762
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40714762
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40510344
58NCOR1_26117541_ChIP-Seq_K562_Human1.39828056
59GATA1_22025678_ChIP-Seq_K562_Human1.39485057
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.39458820
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36621407
62KDM2B_26808549_Chip-Seq_K562_Human1.35185247
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34750346
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34750346
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34566013
66* LXR_22292898_ChIP-Seq_THP-1_Human1.34355204
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.33791737
68* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33081460
69MAF_26560356_Chip-Seq_TH2_Human1.32249085
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32132105
71* FOXO3_23340844_ChIP-Seq_DLD1_Human1.30676382
72* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29842990
73* EP300_21415370_ChIP-Seq_HL-1_Mouse1.27246245
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27011981
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26466300
76GATA2_19941826_ChIP-Seq_K562_Human1.26210177
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25938353
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.25717853
79* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25674373
80* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25179406
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25174792
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25107626
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24570405
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.22913479
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22720845
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22647532
87RACK7_27058665_Chip-Seq_MCF-7_Human1.20945955
88* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20519155
89GATA3_27048872_Chip-Seq_THYMUS_Human1.20418437
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20240718
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18505294
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17901271
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16163477
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15696622
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14956044
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14179216
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13975073
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13687312
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.13141977
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12976786
101RUNX_20019798_ChIP-Seq_JUKART_Human1.12833155
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12240561
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.11705426
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10845835
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.10174170
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.09297067
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.09297067
108* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08586187
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07924925
110* VDR_24787735_ChIP-Seq_THP-1_Human1.07896913
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07868792
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.07253612
113FOXA2_19822575_ChIP-Seq_HepG2_Human1.06951459
114ESR1_20079471_ChIP-ChIP_T-47D_Human1.06236040
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05077268
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04759424
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04138265
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03202490
119TP53_16413492_ChIP-PET_HCT116_Human1.02682985
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02297327
121GATA1_19941826_ChIP-Seq_K562_Human1.01804747
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00782766
123TFEB_21752829_ChIP-Seq_HELA_Human1.00685813
124CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99838289
125* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99095842
126GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98893064
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98574324
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97949043
129KDM2B_26808549_Chip-Seq_JURKAT_Human0.97497924
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97281418
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97072655
132* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96806698
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96359788
134CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95592994
135* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95323815
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94816735
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94815374
138EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94636186
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93798811
140KDM2B_26808549_Chip-Seq_DND41_Human0.93007868
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91359611
142* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91237844
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.91031895
144UBF1/2_26484160_Chip-Seq_HMECs_Human0.90418679
145* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90129442
146SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89938700
147SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89559802
148SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89021415
149KLF5_25053715_ChIP-Seq_YYC3_Human0.88837225
150* SPI1_23127762_ChIP-Seq_K562_Human0.88807203
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88667768
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88667768
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88384410
154JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88110320
155CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87578082
156PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86680184
157EZH2_27294783_Chip-Seq_ESCs_Mouse0.86282834
158RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86205187
159EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86205187
160SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86089573
161KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85601437
162SOX2_20726797_ChIP-Seq_SW620_Human0.85495553
163WT1_19549856_ChIP-ChIP_CCG9911_Human0.85424010
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85248848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog6.31676795
2MP0003011_delayed_dark_adaptation5.66818289
3MP0003724_increased_susceptibility_to4.26282286
4MP0005253_abnormal_eye_physiology3.99794285
5MP0006072_abnormal_retinal_apoptosis3.81190625
6* MP0002090_abnormal_vision3.59389838
7MP0003950_abnormal_plasma_membrane3.52009088
8MP0001835_abnormal_antigen_presentation2.91895982
9MP0005451_abnormal_body_composition2.66012162
10* MP0005195_abnormal_posterior_eye2.65723127
11MP0001324_abnormal_eye_pigmentation2.61726660
12MP0005058_abnormal_lysosome_morphology2.54967337
13MP0010368_abnormal_lymphatic_system2.35906975
14MP0005025_abnormal_response_to2.27565752
15MP0005000_abnormal_immune_tolerance2.26243958
16MP0008260_abnormal_autophagy2.23368563
17MP0005387_immune_system_phenotype2.19732744
18MP0001790_abnormal_immune_system2.19732744
19MP0000685_abnormal_immune_system2.18461953
20MP0003172_abnormal_lysosome_physiology2.17205195
21MP0001346_abnormal_lacrimal_gland2.13458081
22MP0005391_vision/eye_phenotype2.10608529
23MP0009785_altered_susceptibility_to2.09942320
24MP0008004_abnormal_stomach_pH2.05544360
25MP0005464_abnormal_platelet_physiology2.04439954
26MP0001800_abnormal_humoral_immune2.04407879
27MP0005257_abnormal_intraocular_pressure2.04343502
28MP0002452_abnormal_antigen_presenting2.03925185
29MP0005671_abnormal_response_to2.00991556
30MP0002723_abnormal_immune_serum1.98774525
31MP0003300_gastrointestinal_ulcer1.95884464
32MP0002148_abnormal_hypersensitivity_rea1.95528929
33MP0002420_abnormal_adaptive_immunity1.93812089
34MP0000569_abnormal_digit_pigmentation1.93362126
35MP0001819_abnormal_immune_cell1.93052890
36MP0002877_abnormal_melanocyte_morpholog1.92285866
37MP0003303_peritoneal_inflammation1.89431289
38MP0002405_respiratory_system_inflammati1.78354063
39MP0010030_abnormal_orbit_morphology1.63072661
40MP0001879_abnormal_lymphatic_vessel1.62516739
41MP0000858_altered_metastatic_potential1.61497617
42MP0005167_abnormal_blood-brain_barrier1.60441745
43MP0003705_abnormal_hypodermis_morpholog1.59049332
44MP0009840_abnormal_foam_cell1.58085327
45MP0010155_abnormal_intestine_physiology1.53602555
46MP0005248_abnormal_Harderian_gland1.52248980
47* MP0002229_neurodegeneration1.51119739
48MP0001845_abnormal_inflammatory_respons1.50671910
49MP0002132_abnormal_respiratory_system1.50244775
50MP0004510_myositis1.50185902
51MP0003763_abnormal_thymus_physiology1.49243806
52MP0002398_abnormal_bone_marrow1.48568910
53MP0003690_abnormal_glial_cell1.46551023
54MP0003566_abnormal_cell_adhesion1.44980283
55MP0009278_abnormal_bone_marrow1.44763097
56MP0000716_abnormal_immune_system1.44699172
57MP0004883_abnormal_blood_vessel1.43437741
58MP0008438_abnormal_cutaneous_collagen1.39528047
59MP0002396_abnormal_hematopoietic_system1.39356192
60MP0005397_hematopoietic_system_phenotyp1.38613308
61MP0001545_abnormal_hematopoietic_system1.38613308
62MP0005197_abnormal_uvea_morphology1.34174572
63MP0002254_reproductive_system_inflammat1.31759368
64MP0002722_abnormal_immune_system1.29792508
65MP0003091_abnormal_cell_migration1.29633796
66MP0004019_abnormal_vitamin_homeostasis1.28259757
67MP0005623_abnormal_meninges_morphology1.27891531
68MP0009333_abnormal_splenocyte_physiolog1.27873999
69MP0003045_fibrosis1.24613615
70MP0000689_abnormal_spleen_morphology1.23731383
71MP0004272_abnormal_basement_membrane1.23671578
72MP0003656_abnormal_erythrocyte_physiolo1.23635692
73MP0000733_abnormal_muscle_development1.23332095
74MP0008469_abnormal_protein_level1.21674330
75MP0002429_abnormal_blood_cell1.20793100
76MP0009764_decreased_sensitivity_to1.19525637
77MP0004808_abnormal_hematopoietic_stem1.18888569
78MP0004782_abnormal_surfactant_physiolog1.18563618
79MP0003634_abnormal_glial_cell1.17789875
80MP0010386_abnormal_urinary_bladder1.16558090
81MP0000343_altered_response_to1.14503489
82MP0003453_abnormal_keratinocyte_physiol1.13143957
83MP0000703_abnormal_thymus_morphology1.12679598
84MP0001853_heart_inflammation1.12134771
85MP0005310_abnormal_salivary_gland1.11916054
86MP0010352_gastrointestinal_tract_polyps1.11715347
87MP0002928_abnormal_bile_duct1.11648759
88MP0001958_emphysema1.10327962
89MP0001502_abnormal_circadian_rhythm1.09227455
90MP0003075_altered_response_to1.06562353
91MP0005076_abnormal_cell_differentiation1.05585174
92MP0004084_abnormal_cardiac_muscle1.05228401
93MP0005390_skeleton_phenotype1.00846340
94MP0003279_aneurysm1.00560950
95MP0008775_abnormal_heart_ventricle0.98076307
96MP0005595_abnormal_vascular_smooth0.97765137
97MP0003191_abnormal_cellular_cholesterol0.96081694
98MP0000465_gastrointestinal_hemorrhage0.95807069
99MP0002998_abnormal_bone_remodeling0.93697609
100MP0003866_abnormal_defecation0.92854060
101MP0004043_abnormal_pH_regulation0.91191686
102MP0005166_decreased_susceptibility_to0.91019437
103MP0003436_decreased_susceptibility_to0.90643185
104MP0002277_abnormal_respiratory_mucosa0.89449024
105MP0003221_abnormal_cardiomyocyte_apopto0.89067164
106MP0004185_abnormal_adipocyte_glucose0.89020197
107MP0000604_amyloidosis0.88816216
108MP0004381_abnormal_hair_follicle0.88644337
109MP0003795_abnormal_bone_structure0.85613709
110MP0003828_pulmonary_edema0.85204290
111MP0002896_abnormal_bone_mineralization0.84291381
112MP0003329_amyloid_beta_deposits0.84273728
113MP0006082_CNS_inflammation0.81725611
114MP0000920_abnormal_myelination0.81020053
115MP0001299_abnormal_eye_distance/0.80416557
116MP0005670_abnormal_white_adipose0.79036349
117* MP0002752_abnormal_somatic_nervous0.78884885
118MP0002295_abnormal_pulmonary_circulatio0.78436626
119MP0001533_abnormal_skeleton_physiology0.77675291
120MP0002166_altered_tumor_susceptibility0.77037842
121MP0009763_increased_sensitivity_to0.76563794
122MP0008961_abnormal_basal_metabolism0.76493749
123MP0006054_spinal_hemorrhage0.75937396
124MP0002909_abnormal_adrenal_gland0.74908586
125MP0002168_other_aberrant_phenotype0.73487577
126MP0003283_abnormal_digestive_organ0.72996304
127MP0002108_abnormal_muscle_morphology0.72403481
128MP0005023_abnormal_wound_healing0.70041438
129MP0008789_abnormal_olfactory_epithelium0.69957604
130MP0000249_abnormal_blood_vessel0.69527318
131MP0001984_abnormal_olfaction0.68636591
132MP0001849_ear_inflammation0.68506619
133MP0010234_abnormal_vibrissa_follicle0.68286333
134MP0009780_abnormal_chondrocyte_physiolo0.67979268
135MP0000490_abnormal_crypts_of0.67934656
136MP0004036_abnormal_muscle_relaxation0.67693166
137MP0004858_abnormal_nervous_system0.67519476
138MP0005394_taste/olfaction_phenotype0.67491129
139MP0005499_abnormal_olfactory_system0.67491129
140MP0005621_abnormal_cell_physiology0.67335720
141MP0003252_abnormal_bile_duct0.66824061
142MP0008875_abnormal_xenobiotic_pharmacok0.66621622
143MP0001614_abnormal_blood_vessel0.66484866
144MP0002234_abnormal_pharynx_morphology0.66459194
145MP0009765_abnormal_xenobiotic_induced0.65666811
146MP0001915_intracranial_hemorrhage0.65438221
147MP0004264_abnormal_extraembryonic_tissu0.64742897
148MP0001756_abnormal_urination0.64526326
149MP0003448_altered_tumor_morphology0.64484825
150MP0003195_calcinosis0.64474567
151MP0005164_abnormal_response_to0.63622022
152MP0004130_abnormal_muscle_cell0.63467836
153MP0002419_abnormal_innate_immunity0.62486541
154MP0002133_abnormal_respiratory_system0.61884064
155MP0001851_eye_inflammation0.61841966
156MP0000749_muscle_degeneration0.61309454
157MP0010678_abnormal_skin_adnexa0.61057128
158MP0000767_abnormal_smooth_muscle0.60596666
159MP0003183_abnormal_peptide_metabolism0.60363878
160MP0005193_abnormal_anterior_eye0.59912936
161MP0005165_increased_susceptibility_to0.59122313
162MP0000003_abnormal_adipose_tissue0.58227168
163MP0002925_abnormal_cardiovascular_devel0.57365879
164MP0004947_skin_inflammation0.57258196

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)7.21032167
2Central scotoma (HP:0000603)6.92305730
3Abnormality of macular pigmentation (HP:0008002)6.78819740
4Abnormal rod and cone electroretinograms (HP:0008323)5.69409851
5Scotoma (HP:0000575)5.59674748
6Pigmentary retinal degeneration (HP:0001146)5.54695474
7Dyschromatopsia (HP:0007641)5.52634612
8Recurrent bacterial skin infections (HP:0005406)5.17190460
9Absent rod-and cone-mediated responses on ERG (HP:0007688)4.71332801
10Chorioretinal atrophy (HP:0000533)4.64522208
11Decreased central vision (HP:0007663)4.56741510
12Attenuation of retinal blood vessels (HP:0007843)4.45337731
13Myositis (HP:0100614)4.30198471
14Orchitis (HP:0100796)4.28267740
15Recurrent gram-negative bacterial infections (HP:0005420)4.19329683
16Abolished electroretinogram (ERG) (HP:0000550)4.09070451
17Severe visual impairment (HP:0001141)3.93073709
18Retrobulbar optic neuritis (HP:0100654)3.85754491
19Optic neuritis (HP:0100653)3.85754491
20Increased cerebral lipofuscin (HP:0011813)3.72886143
21Cone-rod dystrophy (HP:0000548)3.69014208
22Photophobia (HP:0000613)3.49739779
23Choroideremia (HP:0001139)3.45583599
24Mediastinal lymphadenopathy (HP:0100721)3.45247210
25Pendular nystagmus (HP:0012043)3.42733847
26Macular degeneration (HP:0000608)3.38330285
27Spontaneous hematomas (HP:0007420)3.36863897
28Progressive visual loss (HP:0000529)3.28602447
29Stomatitis (HP:0010280)3.19179262
30Increased corneal curvature (HP:0100692)3.16683942
31Keratoconus (HP:0000563)3.16683942
32Gastrointestinal infarctions (HP:0005244)3.15674597
33Obstructive lung disease (HP:0006536)3.15552280
34Chronic obstructive pulmonary disease (HP:0006510)3.15552280
35Recurrent skin infections (HP:0001581)3.15532290
36Type II diabetes mellitus (HP:0005978)3.14119165
37Recurrent fungal infections (HP:0002841)3.10230359
38Increased neuronal autofluorescent lipopigment (HP:0002074)3.09761191
39Retinal atrophy (HP:0001105)2.94154019
40Cellulitis (HP:0100658)2.83829629
41Keratoconjunctivitis sicca (HP:0001097)2.80324399
42Elevated erythrocyte sedimentation rate (HP:0003565)2.79771150
43Congenital sensorineural hearing impairment (HP:0008527)2.79034330
44Dysostosis multiplex (HP:0000943)2.77840999
45Increased IgE level (HP:0003212)2.75887196
46Peritonitis (HP:0002586)2.68109324
47Meningitis (HP:0001287)2.67345158
48Constricted visual fields (HP:0001133)2.66239934
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65614184
50Urticaria (HP:0001025)2.63331381
51T lymphocytopenia (HP:0005403)2.60866651
52Arterial thrombosis (HP:0004420)2.58699277
53Posterior subcapsular cataract (HP:0007787)2.55158475
54Mucopolysacchariduria (HP:0008155)2.52620856
55Urinary glycosaminoglycan excretion (HP:0003541)2.52620856
56Abnormality of polysaccharide metabolism (HP:0011012)2.51858239
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51858239
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51858239
59Amyloidosis (HP:0011034)2.51283936
60Prolonged bleeding time (HP:0003010)2.50202893
61Axonal loss (HP:0003447)2.49007972
62Keratoconjunctivitis (HP:0001096)2.48103542
63Chronic mucocutaneous candidiasis (HP:0002728)2.47459873
64Recurrent cutaneous fungal infections (HP:0011370)2.47459873
65Chest pain (HP:0100749)2.45394105
66Osteomyelitis (HP:0002754)2.41238936
67Vacuolated lymphocytes (HP:0001922)2.40064273
68Vasculitis (HP:0002633)2.36735071
69Slow saccadic eye movements (HP:0000514)2.32738389
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32385663
71Abnormality of T cell number (HP:0011839)2.32027786
72Gingival bleeding (HP:0000225)2.28578384
73Urethral obstruction (HP:0000796)2.28406439
74Retinitis pigmentosa (HP:0000510)2.27536637
75Encephalitis (HP:0002383)2.26540722
76Subacute progressive viral hepatitis (HP:0006572)2.26153999
77Segmental peripheral demyelination/remyelination (HP:0003481)2.23801770
78Epistaxis (HP:0000421)2.20509721
79Hemoptysis (HP:0002105)2.20492470
80Abnormality of liposaccharide metabolism (HP:0010968)2.20101437
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.20101437
82Abnormality of glycolipid metabolism (HP:0010969)2.20101437
83Abnormal delayed hypersensitivity skin test (HP:0002963)2.19950099
84Episodic fever (HP:0001954)2.16497984
85Subcapsular cataract (HP:0000523)2.13794989
86Premature rupture of membranes (HP:0001788)2.12647103
87Recurrent viral infections (HP:0004429)2.12286470
88Thick nail (HP:0001805)2.11929504
89Pulmonary infiltrates (HP:0002113)2.05627283
90Abnormality of the peritoneum (HP:0002585)2.04277427
91Polycythemia (HP:0001901)2.03952957
92Leukocytosis (HP:0001974)2.03045242
93Vitreoretinal degeneration (HP:0000655)2.01019063
94Congenital stationary night blindness (HP:0007642)11.9652920
95Premature loss of primary teeth (HP:0006323)1.99884575
96Anorexia (HP:0002039)1.99344947
97Inflammation of the large intestine (HP:0002037)1.99259714
98Hepatosplenomegaly (HP:0001433)1.98447567
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98430201
100Gastrointestinal inflammation (HP:0004386)1.98069152
101Abnormal platelet volume (HP:0011876)1.96310639
102Pulmonary embolism (HP:0002204)1.95650219
103Arterial tortuosity (HP:0005116)1.92491787
104Colitis (HP:0002583)1.88066876
105Acne (HP:0001061)1.87986279
106Interstitial pulmonary disease (HP:0006530)1.85236653
107Abnormality of the endocardium (HP:0004306)1.84312776
108Dilatation of the ascending aorta (HP:0005111)1.83797406
109Pustule (HP:0200039)1.83158920
110Glomerulopathy (HP:0100820)1.83074409
111Increased serum ferritin (HP:0003281)1.82518516
112Loss of speech (HP:0002371)1.82160925
113Cerebral aneurysm (HP:0004944)1.81513000
114Mutism (HP:0002300)1.81111692
115Petechiae (HP:0000967)1.81035922
116Viral hepatitis (HP:0006562)1.79150124
117Metaphyseal cupping (HP:0003021)1.78966276
118Abnormality of macrophages (HP:0004311)1.78228212
119Neurofibrillary tangles (HP:0002185)1.76829115
120Vascular tortuosity (HP:0004948)1.76467853
121Myocardial infarction (HP:0001658)1.76455419
122Sepsis (HP:0100806)1.75056046
123Purpura (HP:0000979)1.74663413
124Supranuclear gaze palsy (HP:0000605)1.73633102
125Distal lower limb amyotrophy (HP:0008944)1.72281878
126Distal upper limb amyotrophy (HP:0007149)1.71330166
127Upper limb amyotrophy (HP:0009129)1.71330166
128Amaurosis fugax (HP:0100576)1.70568202
129Absent frontal sinuses (HP:0002688)1.70071824
130Eczematoid dermatitis (HP:0000976)1.69060076
131Granulocytopenia (HP:0001913)1.68685159
132Fatigue (HP:0012378)1.68487375
133Increased connective tissue (HP:0009025)1.66755966
134Esophageal varix (HP:0002040)1.66628665
135Spinal cord lesions (HP:0100561)1.65153970
136Syringomyelia (HP:0003396)1.65153970
137Skin ulcer (HP:0200042)1.64615562
138Autoimmune thrombocytopenia (HP:0001973)1.64162648
139Increased circulating renin level (HP:0000848)1.63576421
140Abnormality of the fingertips (HP:0001211)1.62554453
141Gangrene (HP:0100758)1.62178653
142Albinism (HP:0001022)1.60215908
143Severe Myopia (HP:0011003)1.57576403
144Aplasia/Hypoplasia of the fovea (HP:0008060)1.56365360
145Hypoplasia of the fovea (HP:0007750)1.56365360
146Spondylolisthesis (HP:0003302)1.56342140
147Lower limb amyotrophy (HP:0007210)1.55430355
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.54863246
149Osteolytic defects of the hand bones (HP:0009699)1.54863246
150Systemic lupus erythematosus (HP:0002725)1.51243599
151Broad metatarsal (HP:0001783)1.48653476
152Submucous cleft hard palate (HP:0000176)1.47596577
153Atrophic scars (HP:0001075)1.46872768
154Aortic dissection (HP:0002647)1.44017143
155Hematochezia (HP:0002573)1.43961139
156Aortic aneurysm (HP:0004942)1.43189531
157Neuronal loss in central nervous system (HP:0002529)1.41410646
158Prolonged QT interval (HP:0001657)1.39642097
159Cerebral inclusion bodies (HP:0100314)1.39327489
160Scapular winging (HP:0003691)1.38829120
161Disinhibition (HP:0000734)1.38340129
162Shallow orbits (HP:0000586)1.37700029
163Recurrent abscess formation (HP:0002722)1.37138290
164Increased CSF protein (HP:0002922)1.36783288
165Aplasia/Hypoplasia affecting the retina (HP:0008061)1.36242460
166Aplasia/Hypoplasia of the macula (HP:0008059)1.36078262
167Gingivitis (HP:0000230)1.35656952
168Abnormality of the fovea (HP:0000493)1.34913741
169Exercise-induced muscle cramps (HP:0003710)1.34909534
170Genetic anticipation (HP:0003743)1.34643271
171Macroorchidism (HP:0000053)1.34637908
172Polar cataract (HP:0010696)1.34637308
173Coarse hair (HP:0002208)1.34245068
174Focal segmental glomerulosclerosis (HP:0000097)1.33528095
175Septo-optic dysplasia (HP:0100842)1.32446671
176Hyperactive renin-angiotensin system (HP:0000841)1.29251787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.29711744
2PBK3.61996018
3GRK13.46303920
4BLK2.79003135
5IRAK42.65108380
6MAP2K32.63120067
7INSRR2.54175075
8RIPK12.28978497
9TTN2.27565849
10EPHB12.23058348
11MAP4K12.09313411
12CAMK1D2.05377612
13KSR22.01568935
14CAMK1G1.98918239
15ERN11.97253810
16ZAP701.91414145
17IRAK31.83853200
18JAK31.71453831
19TAOK31.67577965
20CDK121.62654853
21LATS11.56700145
22PAK61.51803235
23TAOK21.50035520
24SMG11.49642798
25EPHA31.48828316
26MAP3K11.47809114
27HIPK21.47558874
28TGFBR21.45463307
29TAOK11.40946501
30JAK21.39019911
31DMPK1.34095799
32YES11.32209023
33PTK21.31893915
34PTK61.31263200
35BRD41.30737716
36BTK1.26023061
37NUAK11.25665166
38GRK61.25195924
39IRAK11.21240036
40WNK11.15670174
41SIK21.12915813
42CDC42BPA1.11823321
43MATK1.11351159
44PAK31.10374450
45BMX1.10063099
46WNK41.06685046
47STK101.05232065
48FER1.05134296
49IKBKE1.04570539
50TRIB31.04249417
51STK381.03887770
52MAP3K61.02789204
53TIE11.01276063
54DYRK1B1.00126224
55MARK20.99862539
56MAPK150.99720896
57SIK10.98042213
58SYK0.98015513
59TYK20.97876799
60MAP3K140.97457778
61FGFR30.97020352
62MAP3K30.91675519
63MAP3K130.91188954
64SIK30.90887272
65BMPR20.90679038
66PRPF4B0.89081454
67TRPM70.88726408
68MET0.87418392
69JAK10.87242483
70PDGFRA0.86804495
71LYN0.86651301
72PDPK10.86463597
73DDR20.86441100
74KDR0.84435176
75MAP3K110.83865434
76TNK20.83745564
77CAMK2D0.83594291
78MAPK70.83105478
79KSR10.82332704
80CDK60.82103480
81MTOR0.81760168
82PRKAA20.80424120
83PRKCH0.79571835
84PAK40.79557181
85PDGFRB0.79393511
86MAP3K20.79251257
87PDK10.78728827
88PAK20.78544583
89CSF1R0.78183768
90STK390.77808869
91PRKD10.76802066
92LCK0.76326724
93EPHB20.74775026
94MAP3K70.74525039
95KIT0.73870822
96TXK0.73813008
97CSK0.73342070
98RAF10.72672161
99FRK0.72310685
100MARK30.72225172
101FES0.71688210
102MOS0.69825747
103LRRK20.69160362
104PTK2B0.68825495
105ICK0.68296814
106MAP3K80.66509006
107GSK3A0.65478527
108TBK10.64680057
109NTRK10.64586405
110OXSR10.64585015
111PRKCE0.64362077
112RPS6KA40.63687342
113FGR0.63498442
114EEF2K0.62849398
115ITK0.62644853
116RET0.62036731
117PRKG20.60845070
118MAP2K20.60303051
119CDK90.59227829
120INSR0.58951460
121RPS6KL10.58515270
122RPS6KC10.58515270
123PKN20.57720170
124ERBB20.56666869
125HCK0.56342681
126SRC0.56193517
127FYN0.56039173
128IRAK20.55777893
129EGFR0.55173819
130MAP3K50.55032703
131CLK10.54802956
132ABL10.54041941
133STK30.53443075
134IKBKB0.53433915
135FGFR40.53193488
136PIK3CG0.52638150
137SGK30.52529358
138PKN10.52368654
139CAMKK10.51550255
140MAPK120.50649719
141CSNK1D0.50629127
142CHUK0.50558400
143ALK0.49165967
144NEK90.49036754
145RPS6KA20.48602378
146SGK2230.47994370
147SGK4940.47994370
148PRKAA10.47604824
149NLK0.47056150
150PRKD20.47019615
151MAP3K100.46733181
152GRK70.44145199

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.82044780
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.10019179
3B cell receptor signaling pathway_Homo sapiens_hsa046622.00762116
4Lysosome_Homo sapiens_hsa041421.91968639
5Acute myeloid leukemia_Homo sapiens_hsa052211.88196739
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74574675
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68514339
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66056940
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.56867858
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55388657
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53879406
12Measles_Homo sapiens_hsa051621.46696968
13Legionellosis_Homo sapiens_hsa051341.45792614
14Mineral absorption_Homo sapiens_hsa049781.43862547
15Non-small cell lung cancer_Homo sapiens_hsa052231.43828613
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.40867665
17Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37059927
18Dilated cardiomyopathy_Homo sapiens_hsa054141.37051870
19Influenza A_Homo sapiens_hsa051641.36664064
20Circadian rhythm_Homo sapiens_hsa047101.33973704
21Pancreatic cancer_Homo sapiens_hsa052121.32462805
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29977463
23T cell receptor signaling pathway_Homo sapiens_hsa046601.27955012
24Hepatitis B_Homo sapiens_hsa051611.27087029
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27035195
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25903438
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24121259
28Synaptic vesicle cycle_Homo sapiens_hsa047211.22123909
29Graft-versus-host disease_Homo sapiens_hsa053321.20661144
30Hematopoietic cell lineage_Homo sapiens_hsa046401.19036610
31Hepatitis C_Homo sapiens_hsa051601.18853228
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.18182720
33GABAergic synapse_Homo sapiens_hsa047271.16740995
34VEGF signaling pathway_Homo sapiens_hsa043701.16495325
35Allograft rejection_Homo sapiens_hsa053301.16477024
36Shigellosis_Homo sapiens_hsa051311.09606970
37Type II diabetes mellitus_Homo sapiens_hsa049301.09391635
38Prolactin signaling pathway_Homo sapiens_hsa049171.08007912
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07993326
40Adherens junction_Homo sapiens_hsa045201.05170079
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04176845
42Herpes simplex infection_Homo sapiens_hsa051681.04175816
43Apoptosis_Homo sapiens_hsa042101.03436330
44ECM-receptor interaction_Homo sapiens_hsa045121.03337498
45Endometrial cancer_Homo sapiens_hsa052131.02718810
46Other glycan degradation_Homo sapiens_hsa005111.02483290
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01529077
48Antigen processing and presentation_Homo sapiens_hsa046121.01324512
49Viral myocarditis_Homo sapiens_hsa054161.01252546
50Autoimmune thyroid disease_Homo sapiens_hsa053201.00340136
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.99707555
52Insulin secretion_Homo sapiens_hsa049110.97438151
53Pertussis_Homo sapiens_hsa051330.95472778
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95229410
55Thyroid cancer_Homo sapiens_hsa052160.94453301
56Focal adhesion_Homo sapiens_hsa045100.93724254
57African trypanosomiasis_Homo sapiens_hsa051430.91119064
58Morphine addiction_Homo sapiens_hsa050320.90088953
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.88862733
60Renal cell carcinoma_Homo sapiens_hsa052110.88470042
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88462055
62Rheumatoid arthritis_Homo sapiens_hsa053230.88018853
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87906069
64Type I diabetes mellitus_Homo sapiens_hsa049400.87894297
65Osteoclast differentiation_Homo sapiens_hsa043800.87662725
66ABC transporters_Homo sapiens_hsa020100.86446972
67Bladder cancer_Homo sapiens_hsa052190.86283344
68Proteoglycans in cancer_Homo sapiens_hsa052050.84996851
69Cholinergic synapse_Homo sapiens_hsa047250.83839267
70Renin secretion_Homo sapiens_hsa049240.83594323
71Staphylococcus aureus infection_Homo sapiens_hsa051500.81863830
72Olfactory transduction_Homo sapiens_hsa047400.79457694
73Circadian entrainment_Homo sapiens_hsa047130.78370279
74Amoebiasis_Homo sapiens_hsa051460.78144663
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77774090
76Phagosome_Homo sapiens_hsa041450.77040110
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77021695
78GnRH signaling pathway_Homo sapiens_hsa049120.76284881
79Bile secretion_Homo sapiens_hsa049760.75805057
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.75788307
81FoxO signaling pathway_Homo sapiens_hsa040680.75345288
82Viral carcinogenesis_Homo sapiens_hsa052030.75264084
83ErbB signaling pathway_Homo sapiens_hsa040120.72362649
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71870152
85Oxytocin signaling pathway_Homo sapiens_hsa049210.70275509
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.70187107
87Chronic myeloid leukemia_Homo sapiens_hsa052200.70006776
88Malaria_Homo sapiens_hsa051440.69590309
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69053794
90Sphingolipid metabolism_Homo sapiens_hsa006000.68842317
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68793186
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68514479
93Primary immunodeficiency_Homo sapiens_hsa053400.67595194
94Colorectal cancer_Homo sapiens_hsa052100.67074848
95Insulin signaling pathway_Homo sapiens_hsa049100.66980723
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66365822
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66323911
98HIF-1 signaling pathway_Homo sapiens_hsa040660.66027661
99Caffeine metabolism_Homo sapiens_hsa002320.65170625
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65099363
101Tuberculosis_Homo sapiens_hsa051520.63890841
102Endocytosis_Homo sapiens_hsa041440.63175627
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.62873805
104Chemokine signaling pathway_Homo sapiens_hsa040620.62522976
105Salivary secretion_Homo sapiens_hsa049700.62144900
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62063201
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61375757
108Inositol phosphate metabolism_Homo sapiens_hsa005620.61142385
109Lysine degradation_Homo sapiens_hsa003100.61127084
110Retinol metabolism_Homo sapiens_hsa008300.60788636
111Leishmaniasis_Homo sapiens_hsa051400.60618932
112cAMP signaling pathway_Homo sapiens_hsa040240.60553465
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60531794
114Estrogen signaling pathway_Homo sapiens_hsa049150.58244667
115Nitrogen metabolism_Homo sapiens_hsa009100.58237313
116Insulin resistance_Homo sapiens_hsa049310.56966607
117Collecting duct acid secretion_Homo sapiens_hsa049660.56524079
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.54143978
119TNF signaling pathway_Homo sapiens_hsa046680.53900173
120Serotonergic synapse_Homo sapiens_hsa047260.53760857
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53634824
122Axon guidance_Homo sapiens_hsa043600.53588197
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53391007
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53364954
125Fructose and mannose metabolism_Homo sapiens_hsa000510.53181554
126Rap1 signaling pathway_Homo sapiens_hsa040150.52924818
127HTLV-I infection_Homo sapiens_hsa051660.52478111
128Toxoplasmosis_Homo sapiens_hsa051450.51744826
129Galactose metabolism_Homo sapiens_hsa000520.50669189
130Epstein-Barr virus infection_Homo sapiens_hsa051690.49555576
131Notch signaling pathway_Homo sapiens_hsa043300.49259779
132Glioma_Homo sapiens_hsa052140.48925386
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.48426434
134Ras signaling pathway_Homo sapiens_hsa040140.48329971
135mTOR signaling pathway_Homo sapiens_hsa041500.47935440
136Choline metabolism in cancer_Homo sapiens_hsa052310.47908612
137MAPK signaling pathway_Homo sapiens_hsa040100.47247350
138Prostate cancer_Homo sapiens_hsa052150.47072510
139Protein digestion and absorption_Homo sapiens_hsa049740.46572855
140Salmonella infection_Homo sapiens_hsa051320.46121581
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.45907078
142Dorso-ventral axis formation_Homo sapiens_hsa043200.45751241
143Ovarian steroidogenesis_Homo sapiens_hsa049130.45573276
144Glutamatergic synapse_Homo sapiens_hsa047240.45334859
145Platelet activation_Homo sapiens_hsa046110.45241078
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44569836
147Starch and sucrose metabolism_Homo sapiens_hsa005000.44105218
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43289190
149Small cell lung cancer_Homo sapiens_hsa052220.43239416
150Gastric acid secretion_Homo sapiens_hsa049710.43102271

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