SLC6A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.38703320
2axon ensheathment in central nervous system (GO:0032291)7.38703320
3response to methylmercury (GO:0051597)4.82051818
4L-amino acid import (GO:0043092)4.71060218
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.61519775
6porphyrin-containing compound biosynthetic process (GO:0006779)4.61021383
7fatty acid elongation (GO:0030497)4.40903316
8gas transport (GO:0015669)4.39633821
9regulation of response to osmotic stress (GO:0047484)4.30328785
10oxygen transport (GO:0015671)4.26084718
11gamma-aminobutyric acid transport (GO:0015812)4.22482411
12regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.21738003
13hemoglobin metabolic process (GO:0020027)4.18664130
14amino acid import (GO:0043090)4.08534709
15L-phenylalanine catabolic process (GO:0006559)3.97313747
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.97313747
17proline biosynthetic process (GO:0006561)3.96947411
18tetrapyrrole biosynthetic process (GO:0033014)3.96195472
19hemidesmosome assembly (GO:0031581)3.93716976
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.90294186
21desmosome organization (GO:0002934)3.89255868
22axon ensheathment (GO:0008366)3.81079921
23ensheathment of neurons (GO:0007272)3.81079921
24myelination (GO:0042552)3.80664372
25sodium ion export (GO:0071436)3.78558209
26L-serine transport (GO:0015825)3.74227050
27myelin maintenance (GO:0043217)3.67150351
28cellular potassium ion homeostasis (GO:0030007)3.64869073
29porphyrin-containing compound metabolic process (GO:0006778)3.63492942
30erythrocyte maturation (GO:0043249)3.62196671
31establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.60311318
32heme biosynthetic process (GO:0006783)3.55591247
33import into cell (GO:0098657)3.50990411
34protein targeting to plasma membrane (GO:0072661)3.50899100
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.49348521
36L-phenylalanine metabolic process (GO:0006558)3.49348521
37erythrocyte development (GO:0048821)3.44963792
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.39878882
39protein retention in ER lumen (GO:0006621)3.37824937
40protoporphyrinogen IX metabolic process (GO:0046501)3.36539905
41establishment or maintenance of apical/basal cell polarity (GO:0035088)3.36245559
42establishment or maintenance of bipolar cell polarity (GO:0061245)3.36245559
43response to lead ion (GO:0010288)3.34454767
44establishment of apical/basal cell polarity (GO:0035089)3.28401209
45synaptic vesicle maturation (GO:0016188)3.24637350
46potassium ion import (GO:0010107)3.19542586
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.16853653
48dicarboxylic acid catabolic process (GO:0043649)3.14271827
49protoporphyrinogen IX biosynthetic process (GO:0006782)3.09300666
50polarized epithelial cell differentiation (GO:0030859)3.07953666
51neurotransmitter uptake (GO:0001504)3.05799708
52Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.04410038
53establishment of tissue polarity (GO:0007164)3.03975165
54establishment of planar polarity (GO:0001736)3.03975165
55potassium ion homeostasis (GO:0055075)3.03235386
56serine transport (GO:0032329)3.00418262
57alpha-linolenic acid metabolic process (GO:0036109)2.95418167
58heme transport (GO:0015886)2.94513646
59semaphorin-plexin signaling pathway (GO:0071526)2.94464432
60Golgi transport vesicle coating (GO:0048200)2.94033994
61COPI coating of Golgi vesicle (GO:0048205)2.94033994
62acidic amino acid transport (GO:0015800)2.93353877
63adult walking behavior (GO:0007628)2.93345766
64neuromuscular process controlling posture (GO:0050884)2.92296898
65skin morphogenesis (GO:0043589)2.89118169
66iron coordination entity transport (GO:1901678)2.88816604
67regulation of translational fidelity (GO:0006450)2.88038236
68regulation of water loss via skin (GO:0033561)2.87852546
69locomotory exploration behavior (GO:0035641)2.87689738
70positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.87180180
71regulation of establishment of planar polarity (GO:0090175)2.87025905
72proline metabolic process (GO:0006560)2.84713536
73cell-substrate junction assembly (GO:0007044)2.84703859
74membrane tubulation (GO:0097320)2.83994944
75regulation of short-term neuronal synaptic plasticity (GO:0048172)2.82183384
76creatine metabolic process (GO:0006600)2.81809396
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79273111
78cellular sodium ion homeostasis (GO:0006883)2.77921338
79coenzyme catabolic process (GO:0009109)2.77677588
80L-serine metabolic process (GO:0006563)2.77672409
81oligodendrocyte differentiation (GO:0048709)2.77358333
82L-glutamate transport (GO:0015813)2.76137991
83cerebellar granule cell differentiation (GO:0021707)2.75650364
84intestinal cholesterol absorption (GO:0030299)2.73440572
85very long-chain fatty acid metabolic process (GO:0000038)2.72946706
86long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.71290603
87glutamate metabolic process (GO:0006536)2.70033468
88cellular protein complex localization (GO:0034629)2.69932703
89C4-dicarboxylate transport (GO:0015740)2.69645393
90convergent extension (GO:0060026)2.69071079
91aspartate family amino acid catabolic process (GO:0009068)2.68428917
92glutamate secretion (GO:0014047)2.68361382
93establishment of mitochondrion localization (GO:0051654)2.67807600
94heme metabolic process (GO:0042168)2.67392850
95establishment of skin barrier (GO:0061436)2.67385739
96eye photoreceptor cell differentiation (GO:0001754)2.66851390
97photoreceptor cell differentiation (GO:0046530)2.66851390
98atrioventricular valve morphogenesis (GO:0003181)2.66833638
99cochlea morphogenesis (GO:0090103)2.66509916
100* glycine transport (GO:0015816)2.65651789
101cysteine metabolic process (GO:0006534)2.63547208
102adherens junction assembly (GO:0034333)2.60756638
103glycerophospholipid catabolic process (GO:0046475)2.60233594
104L-alpha-amino acid transmembrane transport (GO:1902475)2.60030798
105long-chain fatty acid biosynthetic process (GO:0042759)2.58141529
106fatty-acyl-CoA biosynthetic process (GO:0046949)2.56778119
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54420731
108GDP-mannose metabolic process (GO:0019673)2.51792729
109aromatic amino acid family catabolic process (GO:0009074)2.51626836
110apical protein localization (GO:0045176)2.51152403
111focal adhesion assembly (GO:0048041)2.50176518
112cell-substrate adherens junction assembly (GO:0007045)2.50176518
113establishment of monopolar cell polarity (GO:0061162)2.49310794
114establishment or maintenance of monopolar cell polarity (GO:0061339)2.49310794
115neurotransmitter secretion (GO:0007269)2.48890160
116negative regulation of neurotransmitter transport (GO:0051589)2.48679621
117negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.47807064
118cellular response to virus (GO:0098586)2.47782464
119actin filament capping (GO:0051693)2.47690444
120peripheral nervous system axon ensheathment (GO:0032292)2.47668749
121myelination in peripheral nervous system (GO:0022011)2.47668749
122positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46901081
123regulation of G0 to G1 transition (GO:0070316)2.46538550
124cellular modified amino acid catabolic process (GO:0042219)2.46364947
125neuronal action potential propagation (GO:0019227)2.45912417
126G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.45761522
127regulation of nucleobase-containing compound transport (GO:0032239)2.45176297
128ionotropic glutamate receptor signaling pathway (GO:0035235)2.44486040
129neuron remodeling (GO:0016322)2.43720595
130retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.43443105
131regulation of early endosome to late endosome transport (GO:2000641)2.40953751
132regulation of RNA export from nucleus (GO:0046831)2.40200306
133regulation of lipoprotein metabolic process (GO:0050746)2.39637055
134dendrite morphogenesis (GO:0048813)2.38644725
135protein complex localization (GO:0031503)2.37167362
136one-carbon compound transport (GO:0019755)2.37143605
137regulation of synaptic vesicle exocytosis (GO:2000300)2.37125038
138G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.36028191
139peptidyl-tyrosine autophosphorylation (GO:0038083)2.35770481
140protein localization to endosome (GO:0036010)2.35469808
141protein heterotrimerization (GO:0070208)2.35308958
142response to pheromone (GO:0019236)2.35130723
143cerebellar Purkinje cell differentiation (GO:0021702)2.35080336
144regulation of cholesterol biosynthetic process (GO:0045540)2.35055260
145glutamate receptor signaling pathway (GO:0007215)2.34627656
146multicellular organismal water homeostasis (GO:0050891)2.33416624
147cerebellar Purkinje cell layer development (GO:0021680)2.33287316
148presynaptic membrane organization (GO:0097090)2.32946944
149intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.32866366
150regulation of cholesterol homeostasis (GO:2000188)2.32614308
151synaptic vesicle exocytosis (GO:0016079)2.32060850
152extracellular matrix assembly (GO:0085029)2.31863653
153very-low-density lipoprotein particle assembly (GO:0034379)2.31817830
154* neurotransmitter transport (GO:0006836)2.31773688
155asymmetric protein localization (GO:0008105)2.31751464
156negative regulation of protein localization to cell surface (GO:2000009)2.30952666
157alanine transport (GO:0032328)2.30914433
158cofactor catabolic process (GO:0051187)2.30713339
159regulation of neuronal synaptic plasticity (GO:0048168)2.30247020
160synaptic transmission, glutamatergic (GO:0035249)2.29501886
161cholesterol biosynthetic process (GO:0006695)2.28438801
162non-canonical Wnt signaling pathway (GO:0035567)2.27908276
163cell volume homeostasis (GO:0006884)2.27908251
164regulation of neurotransmitter levels (GO:0001505)2.27880997
165vocalization behavior (GO:0071625)2.27744027
166basement membrane organization (GO:0071711)2.27537474
167triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.27493376
168negative regulation of actin filament depolymerization (GO:0030835)2.26856026
169neuron cell-cell adhesion (GO:0007158)2.26141787
170long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.25942118
171regulation of mammary gland epithelial cell proliferation (GO:0033599)2.25927882
172ovulation cycle (GO:0042698)2.25744900
173activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.24307610
174lateral sprouting from an epithelium (GO:0060601)2.23589706
175ventricular system development (GO:0021591)2.23545059
176cellular response to cholesterol (GO:0071397)2.22867404
177serine family amino acid biosynthetic process (GO:0009070)2.22666127
178response to arsenic-containing substance (GO:0046685)2.20524759
179activation of Rac GTPase activity (GO:0032863)2.19994185
180positive regulation of nuclease activity (GO:0032075)2.19163764
181positive regulation of osteoblast proliferation (GO:0033690)2.19013078
182regulation of chromatin binding (GO:0035561)2.18966115
183glutamine family amino acid biosynthetic process (GO:0009084)2.18959133
184hair follicle development (GO:0001942)2.18239248
185camera-type eye morphogenesis (GO:0048593)2.18163103
186UV protection (GO:0009650)2.14456435
187notochord development (GO:0030903)2.11085997
188epithelial cell-cell adhesion (GO:0090136)2.10261776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.76996047
2ZNF263_19887448_ChIP-Seq_K562_Human3.10928525
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.81173526
4E2F7_22180533_ChIP-Seq_HELA_Human2.79355759
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.77825239
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73428375
7* LXR_22292898_ChIP-Seq_THP-1_Human2.56030769
8EZH2_22144423_ChIP-Seq_EOC_Human2.55448451
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46767640
10GBX2_23144817_ChIP-Seq_PC3_Human2.32716914
11RACK7_27058665_Chip-Seq_MCF-7_Human2.32082481
12AR_21572438_ChIP-Seq_LNCaP_Human2.24433923
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23435619
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19865703
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13028529
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11355715
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11355715
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.03975600
19DROSHA_22980978_ChIP-Seq_HELA_Human2.00432626
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97898812
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96117720
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94811697
23* RXR_22158963_ChIP-Seq_LIVER_Mouse1.94425362
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92585960
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.90892968
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90001690
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.89248829
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.87837294
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.87371964
30* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84503908
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83703215
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83386817
33* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82842670
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81570467
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77878211
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.76388349
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76347244
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75807484
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.74995888
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74798078
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73798793
42* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.69352503
43P68_20966046_ChIP-Seq_HELA_Human1.69137081
44* KDM2B_26808549_Chip-Seq_DND41_Human1.68741563
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66945930
46* ATF3_27146783_Chip-Seq_COLON_Human1.65086103
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.64480878
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64388209
49* SMC4_20622854_ChIP-Seq_HELA_Human1.62361759
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.61813505
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61763162
52* CREB1_26743006_Chip-Seq_LNCaP_Human1.61680111
53* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59862465
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.59361505
55CLOCK_20551151_ChIP-Seq_293T_Human1.58834044
56* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57230496
57VDR_21846776_ChIP-Seq_THP-1_Human1.56713934
58REST_21632747_ChIP-Seq_MESCs_Mouse1.56377694
59GATA1_22025678_ChIP-Seq_K562_Human1.55842432
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53209329
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53057891
62* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52008786
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50923826
64* SA1_27219007_Chip-Seq_ERYTHROID_Human1.50466477
65TP53_22127205_ChIP-Seq_IMR90_Human1.47943891
66* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47048620
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46635564
68* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44918342
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44334764
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42877615
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42582646
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41747779
73* TCF7_22412390_ChIP-Seq_EML_Mouse1.41372712
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.40725437
75* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39437322
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.39216847
77* GATA1_19941826_ChIP-Seq_K562_Human1.34731854
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32691356
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32157965
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.31891092
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30732552
82* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30627466
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.30311975
84* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30112181
85* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29874575
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29867275
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29345274
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29128719
89NCOR1_26117541_ChIP-Seq_K562_Human1.26826976
90* KDM2B_26808549_Chip-Seq_K562_Human1.26275688
91* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25404963
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24801907
93* MYC_22102868_ChIP-Seq_BL_Human1.24651682
94* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.24625300
95* FOXA2_19822575_ChIP-Seq_HepG2_Human1.24399665
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22389705
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.20436293
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20408083
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20322241
100* KDM2B_26808549_Chip-Seq_JURKAT_Human1.19654610
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19480486
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16415092
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16251221
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16074092
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15137048
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13856142
107* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13191290
108* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10784336
109TP63_22573176_ChIP-Seq_HFKS_Human1.10543435
110* GATA2_19941826_ChIP-Seq_K562_Human1.10459591
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10098494
112* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08780795
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08468768
114XRN2_22483619_ChIP-Seq_HELA_Human1.07162035
115* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06861538
116SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06787872
117GATA1_26923725_Chip-Seq_HPCs_Mouse1.06769014
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.06461155
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.06144145
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05975807
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05556359
122* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04438250
123ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04263502
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02915660
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02743799
126STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02197868
127TP53_23651856_ChIP-Seq_MEFs_Mouse1.02140501
128BCOR_27268052_Chip-Seq_Bcells_Human1.01318719
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00470699
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00332384
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00125933
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.99719093
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99675284
134ELF1_20517297_ChIP-Seq_JURKAT_Human0.98797768
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98718081
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98506639
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.97056510
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.96788034
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96141118
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96050958
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95770868
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95770868
143CHD1_26751641_Chip-Seq_LNCaP_Human0.95011650
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94942385
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94258864
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94220940
147* STAT3_23295773_ChIP-Seq_U87_Human0.93963260
148SOX2_21211035_ChIP-Seq_LN229_Gbm0.93665575
149* AR_19668381_ChIP-Seq_PC3_Human0.93628115
150POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92568756
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92115849
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.91965135
153* CTCF_27219007_Chip-Seq_Bcells_Human0.91707089
154HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91358366
155CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91156888
156KLF4_19829295_ChIP-Seq_ESCs_Human0.90386429
157SMAD4_21741376_ChIP-Seq_HESCs_Human0.89906392
158P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89786146
159CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89469383
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89309168
161* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88606763
162SMAD4_21799915_ChIP-Seq_A2780_Human0.88489010
163GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88376862
164EP300_21415370_ChIP-Seq_HL-1_Mouse0.87682271
165EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87673240
166* TET1_21490601_ChIP-Seq_MESCs_Mouse0.86837470
167OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86679509
168ARNT_22903824_ChIP-Seq_MCF-7_Human0.86640784
169RXR_22108803_ChIP-Seq_LS180_Human0.86258358
170AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86011351
171PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85762215
172* GATA1_19941827_ChIP-Seq_MEL_Mouse0.84202412
173CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83414864
174AHR_22903824_ChIP-Seq_MCF-7_Human0.83039304
175RING1B_27294783_Chip-Seq_NPCs_Mouse0.82959749
176MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82205244
177TP53_16413492_ChIP-PET_HCT116_Human0.81529421
178HTT_18923047_ChIP-ChIP_STHdh_Human0.81120036
179CTBP1_25329375_ChIP-Seq_LNCAP_Human0.78499311
180* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78131764
181* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.77907794
182STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.77509975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.43260532
2MP0005083_abnormal_biliary_tract3.34751727
3MP0004859_abnormal_synaptic_plasticity3.31899949
4MP0000920_abnormal_myelination3.21418728
5MP0008438_abnormal_cutaneous_collagen2.96581790
6MP0003656_abnormal_erythrocyte_physiolo2.92343430
7MP0003880_abnormal_central_pattern2.89483453
8MP0002139_abnormal_hepatobiliary_system2.85000929
9MP0003329_amyloid_beta_deposits2.79880608
10MP0004885_abnormal_endolymph2.73580723
11MP0003690_abnormal_glial_cell2.71501700
12MP0004270_analgesia2.62705281
13MP0005076_abnormal_cell_differentiation2.52799381
14MP0005423_abnormal_somatic_nervous2.46873378
15MP0005275_abnormal_skin_tensile2.45387991
16MP0005365_abnormal_bile_salt2.36291119
17MP0001486_abnormal_startle_reflex2.32419725
18MP0002064_seizures2.32240718
19* MP0003635_abnormal_synaptic_transmissio2.29034348
20MP0005501_abnormal_skin_physiology2.27916789
21MP0002796_impaired_skin_barrier2.21442509
22MP0009046_muscle_twitch2.17101318
23MP0005085_abnormal_gallbladder_physiolo2.15017558
24MP0003566_abnormal_cell_adhesion2.09132022
25MP0002060_abnormal_skin_morphology2.07985933
26* MP0002272_abnormal_nervous_system2.03184349
27MP0010030_abnormal_orbit_morphology2.02491484
28MP0003453_abnormal_keratinocyte_physiol2.02027146
29MP0003950_abnormal_plasma_membrane2.01795410
30MP0005551_abnormal_eye_electrophysiolog2.01483017
31MP0005360_urolithiasis2.00357091
32MP0001666_abnormal_nutrient_absorption1.97065812
33MP0005503_abnormal_tendon_morphology1.95172592
34* MP0009745_abnormal_behavioral_response1.93078775
35MP0009840_abnormal_foam_cell1.90198760
36MP0005257_abnormal_intraocular_pressure1.84097869
37MP0004147_increased_porphyrin_level1.83235114
38MP0003634_abnormal_glial_cell1.82007330
39MP0008569_lethality_at_weaning1.75484510
40MP0001849_ear_inflammation1.73468262
41MP0010234_abnormal_vibrissa_follicle1.72334496
42MP0005409_darkened_coat_color1.71935375
43MP0002249_abnormal_larynx_morphology1.70229744
44MP0002229_neurodegeneration1.68264290
45MP0005171_absent_coat_pigmentation1.64064634
46MP0004043_abnormal_pH_regulation1.60001133
47MP0000467_abnormal_esophagus_morphology1.58906470
48* MP0002063_abnormal_learning/memory/cond1.58711184
49MP0008875_abnormal_xenobiotic_pharmacok1.58112215
50MP0003632_abnormal_nervous_system1.56208491
51MP0001958_emphysema1.54315749
52MP0003011_delayed_dark_adaptation1.48967140
53MP0001529_abnormal_vocalization1.46543069
54MP0002572_abnormal_emotion/affect_behav1.46125262
55MP0000778_abnormal_nervous_system1.45851082
56MP0000762_abnormal_tongue_morphology1.44615508
57* MP0003633_abnormal_nervous_system1.44245881
58* MP0003631_nervous_system_phenotype1.43737405
59MP0000604_amyloidosis1.42471990
60* MP0004142_abnormal_muscle_tone1.42048528
61MP0001440_abnormal_grooming_behavior1.41790479
62MP0000955_abnormal_spinal_cord1.39432158
63MP0010771_integument_phenotype1.35121372
64MP0004272_abnormal_basement_membrane1.34718717
65* MP0002734_abnormal_mechanical_nocicepti1.34273521
66MP0003941_abnormal_skin_development1.34245183
67MP0005377_hearing/vestibular/ear_phenot1.33621087
68MP0003878_abnormal_ear_physiology1.33621087
69MP0002067_abnormal_sensory_capabilities1.30053031
70MP0000579_abnormal_nail_morphology1.29217376
71MP0001968_abnormal_touch/_nociception1.24897280
72MP0001502_abnormal_circadian_rhythm1.23313871
73MP0002882_abnormal_neuron_morphology1.22909868
74MP0000537_abnormal_urethra_morphology1.20100642
75MP0002098_abnormal_vibrissa_morphology1.19707162
76* MP0002066_abnormal_motor_capabilities/c1.18376683
77MP0002118_abnormal_lipid_homeostasis1.18055289
78MP0000428_abnormal_craniofacial_morphol1.17313942
79MP0005646_abnormal_pituitary_gland1.16705465
80MP0001177_atelectasis1.16627630
81MP0004742_abnormal_vestibular_system1.16479289
82MP0005332_abnormal_amino_acid1.16368862
83MP0001348_abnormal_lacrimal_gland1.15618341
84MP0002733_abnormal_thermal_nociception1.12758051
85MP0005451_abnormal_body_composition1.11909525
86MP0003111_abnormal_nucleus_morphology1.11522212
87MP0009053_abnormal_anal_canal1.11132873
88MP0005386_behavior/neurological_phenoty1.10770946
89MP0004924_abnormal_behavior1.10770946
90* MP0001970_abnormal_pain_threshold1.10391008
91MP0004185_abnormal_adipocyte_glucose1.10100030
92MP0005508_abnormal_skeleton_morphology1.09971449
93MP0000534_abnormal_ureter_morphology1.09775783
94MP0004858_abnormal_nervous_system1.09644135
95MP0001216_abnormal_epidermal_layer1.09447595
96MP0009931_abnormal_skin_appearance1.09440082
97MP0002653_abnormal_ependyma_morphology1.09011621
98MP0001299_abnormal_eye_distance/1.08297334
99MP0003942_abnormal_urinary_system1.07972960
100MP0001905_abnormal_dopamine_level1.07631651
101MP0003115_abnormal_respiratory_system1.07356149
102MP0009384_cardiac_valve_regurgitation1.07116981
103MP0002736_abnormal_nociception_after1.06822453
104MP0003279_aneurysm1.06476936
105MP0009780_abnormal_chondrocyte_physiolo1.06439527
106MP0003868_abnormal_feces_composition1.03756149
107MP0003806_abnormal_nucleotide_metabolis1.03284819
108MP0000377_abnormal_hair_follicle1.03158261
109MP0010329_abnormal_lipoprotein_level1.02750646
110MP0001485_abnormal_pinna_reflex1.01727828
111MP0000747_muscle_weakness0.98589027
112MP0000678_abnormal_parathyroid_gland0.95931059
113MP0003252_abnormal_bile_duct0.95270389
114MP0001188_hyperpigmentation0.94832750
115MP0002090_abnormal_vision0.94764424
116MP0005195_abnormal_posterior_eye0.94474852
117MP0000639_abnormal_adrenal_gland0.93825899
118MP0002089_abnormal_postnatal_growth/wei0.93556258
119MP0000566_synostosis0.92710699
120MP0002822_catalepsy0.92293449
121MP0001501_abnormal_sleep_pattern0.91706323
122MP0005253_abnormal_eye_physiology0.90490595
123MP0003075_altered_response_to0.89664569
124MP0002752_abnormal_somatic_nervous0.88984945
125MP0005623_abnormal_meninges_morphology0.88026266
126MP0005023_abnormal_wound_healing0.86779919
127MP0003195_calcinosis0.85728795
128MP0003091_abnormal_cell_migration0.84991240
129MP0008872_abnormal_physiological_respon0.84616981
130MP0002896_abnormal_bone_mineralization0.84188949
131MP0000751_myopathy0.83368704
132MP0002557_abnormal_social/conspecific_i0.83349502
133MP0002116_abnormal_craniofacial_bone0.82428768
134MP0000003_abnormal_adipose_tissue0.82244406
135MP0004233_abnormal_muscle_weight0.81884984
136MP0002152_abnormal_brain_morphology0.81109313
137* MP0004811_abnormal_neuron_physiology0.80016146
138MP0002111_abnormal_tail_morphology0.79377477
139MP0003861_abnormal_nervous_system0.79143996
140MP0005621_abnormal_cell_physiology0.78297721
141MP0000432_abnormal_head_morphology0.77534746
142MP0002697_abnormal_eye_size0.77127434
143MP0001243_abnormal_dermal_layer0.76805669
144MP0010678_abnormal_skin_adnexa0.75729008
145MP0008260_abnormal_autophagy0.75266768
146MP0001340_abnormal_eyelid_morphology0.74549768
147MP0000049_abnormal_middle_ear0.73749342
148MP0001730_embryonic_growth_arrest0.72961248
149MP0006072_abnormal_retinal_apoptosis0.72874570
150MP0002085_abnormal_embryonic_tissue0.72871528
151* MP0002080_prenatal_lethality0.71843956
152MP0003136_yellow_coat_color0.71479290
153MP0002184_abnormal_innervation0.70918459
154MP0005167_abnormal_blood-brain_barrier0.70569085
155MP0000350_abnormal_cell_proliferation0.69792451
156MP0001664_abnormal_digestion0.69583009
157MP0003755_abnormal_palate_morphology0.69579307
158MP0005584_abnormal_enzyme/coenzyme_acti0.67937059
159MP0009278_abnormal_bone_marrow0.67838432
160MP0001346_abnormal_lacrimal_gland0.67623532
161MP0001963_abnormal_hearing_physiology0.67167289
162MP0002084_abnormal_developmental_patter0.66675185
163MP0000462_abnormal_digestive_system0.64757021
164MP0009672_abnormal_birth_weight0.64501819
165MP0002108_abnormal_muscle_morphology0.59316903
166MP0009379_abnormal_foot_pigmentation0.59080063
167MP0005380_embryogenesis_phenotype0.58452607
168MP0001672_abnormal_embryogenesis/_devel0.58452607
169MP0008789_abnormal_olfactory_epithelium0.58213851
170MP0004133_heterotaxia0.57875178

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.00561642
2Supranuclear gaze palsy (HP:0000605)4.14346014
3Cerebral inclusion bodies (HP:0100314)4.02783762
4Premature rupture of membranes (HP:0001788)3.82747205
5Peripheral hypomyelination (HP:0007182)3.70440958
6Myokymia (HP:0002411)3.60706689
7Aplasia involving bones of the upper limbs (HP:0009823)3.54163045
8Aplasia of the phalanges of the hand (HP:0009802)3.54163045
9Aplasia involving bones of the extremities (HP:0009825)3.54163045
10Ulnar bowing (HP:0003031)3.40747881
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.40536618
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.40536618
13Protrusio acetabuli (HP:0003179)3.39943086
14Intention tremor (HP:0002080)3.39694036
15Ankle clonus (HP:0011448)3.27923977
16Action tremor (HP:0002345)3.26340286
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.20380581
18Onion bulb formation (HP:0003383)3.17253277
19Shallow orbits (HP:0000586)3.17233767
20Atrophic scars (HP:0001075)3.16142472
21Abnormality of nail color (HP:0100643)3.12260165
22Abnormality of the corticospinal tract (HP:0002492)3.10726212
23Abnormal auditory evoked potentials (HP:0006958)3.08355352
24Cerebral hypomyelination (HP:0006808)3.02662158
25Dysmetria (HP:0001310)3.01364999
26Hyperlipoproteinemia (HP:0010980)2.95049504
27Megalencephaly (HP:0001355)2.85148997
28Poikilocytosis (HP:0004447)2.83690225
29Obstructive sleep apnea (HP:0002870)2.79818144
30Deep venous thrombosis (HP:0002625)2.79629912
31Fragile skin (HP:0001030)2.76546987
32Intrahepatic cholestasis (HP:0001406)2.74258351
33Diaphragmatic weakness (HP:0009113)2.72270003
34Spastic gait (HP:0002064)2.72013764
35Postural instability (HP:0002172)2.71198346
36Insomnia (HP:0100785)2.68163873
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.67949361
38Hyperacusis (HP:0010780)2.66339178
39Termporal pattern (HP:0011008)2.66106838
40Insidious onset (HP:0003587)2.66106838
41Focal motor seizures (HP:0011153)2.64377222
42Abnormal gallbladder morphology (HP:0012437)2.64343457
43Acanthocytosis (HP:0001927)2.64034893
44Abnormality of reticulocytes (HP:0004312)2.61739583
45Cholelithiasis (HP:0001081)2.61639094
46Slow saccadic eye movements (HP:0000514)2.61487403
47Torticollis (HP:0000473)2.60852517
48Scanning speech (HP:0002168)2.60183804
49Confusion (HP:0001289)2.60123339
50Bladder diverticulum (HP:0000015)2.58952912
51Upper limb amyotrophy (HP:0009129)2.54268925
52Distal upper limb amyotrophy (HP:0007149)2.54268925
53Alacrima (HP:0000522)2.53775547
54Dysdiadochokinesis (HP:0002075)2.52585146
55Xanthomatosis (HP:0000991)2.50491071
56Pterygium (HP:0001059)2.50158749
57Neonatal short-limb short stature (HP:0008921)2.49971875
58Reticulocytosis (HP:0001923)2.48097256
59Spastic tetraparesis (HP:0001285)2.47334392
60Broad face (HP:0000283)2.44414543
61Ileus (HP:0002595)2.40313969
62Hemiparesis (HP:0001269)2.39021163
63Focal seizures (HP:0007359)2.38955741
64Turricephaly (HP:0000262)2.37833194
65Hand muscle atrophy (HP:0009130)2.37553781
66Cholecystitis (HP:0001082)2.37286520
67Abnormal gallbladder physiology (HP:0012438)2.37286520
68Abnormality of the heme biosynthetic pathway (HP:0010472)2.35326219
69Long palpebral fissure (HP:0000637)2.34845596
70Paraparesis (HP:0002385)2.32493559
71Hemiplegia (HP:0002301)2.28733473
72Abnormality of dentin (HP:0010299)2.26798275
73Spastic paraparesis (HP:0002313)2.24879460
74Clumsiness (HP:0002312)2.21568256
75Atelectasis (HP:0100750)2.20157796
76Depression (HP:0000716)2.19199499
77Craniofacial dystonia (HP:0012179)2.16848021
78Abnormal hemoglobin (HP:0011902)2.15402490
79Wormian bones (HP:0002645)2.12758129
80Choreoathetosis (HP:0001266)2.11846075
81Cervical subluxation (HP:0003308)2.09965285
82Coronal craniosynostosis (HP:0004440)2.09728421
83Morphological abnormality of the inner ear (HP:0011390)2.08779662
84Focal dystonia (HP:0004373)2.08599992
85Clonus (HP:0002169)2.07418108
86Anxiety (HP:0000739)2.06958231
87Increased circulating renin level (HP:0000848)2.04076028
88Natal tooth (HP:0000695)2.01958973
89Metabolic alkalosis (HP:0200114)2.01633796
90Onycholysis (HP:0001806)2.01211454
91Rigidity (HP:0002063)2.00941715
92Axonal loss (HP:0003447)2.00892683
93Mitral regurgitation (HP:0001653)2.00102085
94Generalized tonic-clonic seizures (HP:0002069)1.99213997
95Premature skin wrinkling (HP:0100678)1.99131445
96Status epilepticus (HP:0002133)1.98859288
97Progressive cerebellar ataxia (HP:0002073)1.98042170
98Broad metatarsal (HP:0001783)1.97962547
99CNS hypomyelination (HP:0003429)1.97893881
100Milia (HP:0001056)1.97729698
101Advanced eruption of teeth (HP:0006288)1.97705654
102Humeroradial synostosis (HP:0003041)1.97520044
103Synostosis involving the elbow (HP:0003938)1.97520044
104Genu recurvatum (HP:0002816)1.97161417
105Vertebral compression fractures (HP:0002953)1.95902242
106Epileptic encephalopathy (HP:0200134)1.95826779
107Ankle contracture (HP:0006466)1.94911416
108Infantile muscular hypotonia (HP:0008947)1.94750981
109Hypophosphatemic rickets (HP:0004912)1.94254930
110Lower limb muscle weakness (HP:0007340)1.92781464
111Urinary urgency (HP:0000012)1.92578042
112Vascular tortuosity (HP:0004948)1.91837251
113Neuronal loss in central nervous system (HP:0002529)1.91781969
114Abnormality of the gallbladder (HP:0005264)1.91143806
115Nasal polyposis (HP:0100582)1.90967206
116Abnormality of binocular vision (HP:0011514)1.90335675
117Diplopia (HP:0000651)1.90335675
118Visual hallucinations (HP:0002367)1.90124638
119Sparse lateral eyebrow (HP:0005338)1.89156360
120Paralysis (HP:0003470)1.88088018
121Hyperbilirubinemia (HP:0002904)1.86805701
122Abnormality of saccadic eye movements (HP:0000570)1.86517020
123Partial duplication of thumb phalanx (HP:0009944)1.85916745
124Hammertoe (HP:0001765)1.85486505
125Abolished electroretinogram (ERG) (HP:0000550)1.85355539
126Spinal rigidity (HP:0003306)1.85271257
127Hypokalemic alkalosis (HP:0001949)1.84475259
128Fragile nails (HP:0001808)1.83129536
129Sensory axonal neuropathy (HP:0003390)1.81707173
130Lip pit (HP:0100267)1.80912455
131Decreased lacrimation (HP:0000633)1.80597457
132Thin bony cortex (HP:0002753)1.80505152
133Anteriorly placed anus (HP:0001545)1.80084385
134Biconcave vertebral bodies (HP:0004586)1.79368051
135Truncal ataxia (HP:0002078)1.78547573
136Polycythemia (HP:0001901)1.78339382
137Elbow flexion contracture (HP:0002987)1.77712531
138Morphological abnormality of the pyramidal tract (HP:0002062)1.77630581
139Bowel incontinence (HP:0002607)1.77483557
140Arterial tortuosity (HP:0005116)1.77099824
141Hypoalphalipoproteinemia (HP:0003233)1.75856690
142Bowing of the arm (HP:0006488)1.75821567
143Bowed forearm bones (HP:0003956)1.75821567
144Abnormal eating behavior (HP:0100738)1.75441572
145Choroideremia (HP:0001139)1.75020669
146Thin ribs (HP:0000883)1.74805323
147Hypochromic microcytic anemia (HP:0004840)1.74745117
148Abnormality of the middle phalanges of the toes (HP:0010183)1.74693086
149Choanal stenosis (HP:0000452)1.74682931
150Spastic paraplegia (HP:0001258)1.73686208
151Absent eyelashes (HP:0000561)1.72210081
152Vascular calcification (HP:0004934)1.71632723
153Arnold-Chiari malformation (HP:0002308)1.71040814
154Selective tooth agenesis (HP:0001592)1.70974913
155Abnormality of methionine metabolism (HP:0010901)1.69645103
156Disproportionate tall stature (HP:0001519)1.68958106
157Hyperextensible skin (HP:0000974)1.68737998
158Upper limb muscle weakness (HP:0003484)1.67996633
159Bronchomalacia (HP:0002780)1.67024759
160Blue sclerae (HP:0000592)1.65910251
161Alopecia of scalp (HP:0002293)1.65813857
162Abnormality of the aortic arch (HP:0012303)1.65715910
163Breast hypoplasia (HP:0003187)1.65229689
164Rib fusion (HP:0000902)1.64609931
165Short nail (HP:0001799)1.64013440
166Abnormality of the fingertips (HP:0001211)1.63662732
167Bowel diverticulosis (HP:0005222)1.63066097
168Partial duplication of the phalanx of hand (HP:0009999)1.62957039
169Vertebral arch anomaly (HP:0008438)1.62725309
170Achilles tendon contracture (HP:0001771)1.62472743
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.62387582
172Abnormality of the salivary glands (HP:0010286)1.62309383
173Soft skin (HP:0000977)1.59903004
174Renal duplication (HP:0000075)1.59891073
175Abnormality of the thoracic spine (HP:0100711)1.58912454
176Abnormality of the distal phalanx of the thumb (HP:0009617)1.58803563
177Abnormal large intestine physiology (HP:0012700)1.57174264
178Ankyloglossia (HP:0010296)1.56653692
179Stridor (HP:0010307)1.55432732
180Urethral obstruction (HP:0000796)1.53061039
181Bell-shaped thorax (HP:0001591)1.52386043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.34356157
2MAPK153.28306081
3STK393.21483117
4EIF2AK12.99198043
5SMG12.85806781
6EPHA22.81080721
7OXSR12.61306939
8MAPKAPK52.56461419
9CDK122.45621545
10MST1R2.37059973
11PKN12.29578562
12SGK4942.21373167
13SGK2232.21373167
14PAK62.20709385
15PRKD32.19940010
16EPHB12.14203257
17FGFR22.04357720
18CAMK1D2.00369361
19WNK11.92694464
20NTRK11.87355107
21EPHA41.82269774
22NTRK31.80118560
23NTRK21.76211598
24PDGFRA1.69854905
25MAP3K101.65024692
26TESK11.64170227
27UHMK11.62002324
28SIK11.59503397
29MAP3K91.58547333
30TAOK21.50995589
31ERBB41.50977707
32MTOR1.50713968
33KSR21.50537066
34MARK11.45036740
35MAP3K41.42877827
36PHKG21.40783414
37PHKG11.40783414
38TYRO31.38961521
39MET1.38600619
40BCKDK1.36529833
41LATS21.33341420
42WNK41.32182668
43PTK21.31196290
44IRAK31.30649610
45BMX1.30234608
46MUSK1.28023167
47RPS6KA21.26779608
48CDK191.25428158
49CAMK2G1.24921967
50CAMK2B1.23405441
51PRKCH1.22097147
52LATS11.21876285
53ICK1.20900649
54ROCK21.19407095
55MARK21.18412146
56PINK11.16055796
57MAP2K41.13727060
58CDK51.10718487
59MAP3K31.10483485
60STK381.07141609
61EPHB21.05410709
62HIPK21.05186020
63DAPK21.05100840
64CSNK1G21.04745315
65PRKD11.03489082
66LIMK10.98870109
67CSNK1A1L0.98017057
68FGFR40.96800135
69MAPK130.96347092
70DDR20.95939390
71PRPF4B0.93736912
72CASK0.92064064
73CAMK2D0.91792928
74NEK60.91691941
75CAMKK10.91533068
76CDK150.90321313
77MINK10.89776880
78CAMK2A0.89769058
79TAOK10.89391538
80CSNK1G30.89249426
81RPS6KC10.88545869
82RPS6KL10.88545869
83ARAF0.87378917
84RET0.85672784
85PAK40.84397715
86MAP2K70.84335840
87BRSK10.83759148
88CDK180.81504546
89TNK20.79890458
90TTK0.78918003
91PDPK10.78545583
92CDK140.78232831
93CDK11A0.77190619
94BRAF0.76552311
95SGK30.75495358
96ERN10.75294102
97MAP3K110.75060597
98PRKD20.72933526
99CAMK1G0.71465291
100PAK30.70857304
101PKN20.69994337
102PRKCZ0.68356456
103CDK70.68338311
104CDC42BPA0.67981991
105CSNK1G10.67460548
106LMTK20.67455950
107TNIK0.67302532
108STK110.66526151
109RPS6KA60.66144127
110MAP3K80.65437591
111MAPK120.64733556
112DYRK1B0.64475576
113ERBB20.63246367
114GRK50.63209277
115FGR0.62817428
116BCR0.62631807
117DYRK1A0.60447068
118MAP3K130.59888842
119PRKCG0.59309132
120SGK10.58929418
121PNCK0.58778467
122MAP2K20.58664616
123MAP3K20.58622400
124MAP3K70.58123559
125DYRK30.57965310
126STK40.57618203
127PAK20.57161544
128TTN0.55112927
129PDGFRB0.55055465
130CSNK1D0.54238523
131PBK0.53552817
132MAP2K10.53079874
133RPS6KA30.52353814
134ROCK10.52322700
135SGK20.51777666
136TRPM70.51043104
137MAPKAPK30.50975042
138EEF2K0.49829819
139MAPK110.49184109
140RIPK10.49127231
141CHEK20.49032179
142PTK60.49002633
143MAP3K10.48931441
144AURKA0.47534307
145PIM20.46900011
146AKT20.44008461
147STK240.43209696
148MAPK100.40583580
149DYRK20.39974908
150MAP2K30.39349544
151CHEK10.38530014
152MAP3K60.38338789
153MAPK90.37144080
154CDK90.35036533
155PRKCI0.33557947
156SIK20.33551005
157TESK20.31925110
158CDK20.31868492
159ABL20.31757892

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.52445285
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73392478
3Vitamin B6 metabolism_Homo sapiens_hsa007502.52616242
4Steroid biosynthesis_Homo sapiens_hsa001002.42305803
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13194170
6Notch signaling pathway_Homo sapiens_hsa043302.09627589
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02557809
8Fatty acid elongation_Homo sapiens_hsa000622.02253008
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00088694
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.93882243
11Arginine biosynthesis_Homo sapiens_hsa002201.80740089
12GABAergic synapse_Homo sapiens_hsa047271.78229395
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77927721
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.73952653
15Bladder cancer_Homo sapiens_hsa052191.70670128
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70248440
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66415293
18Pancreatic secretion_Homo sapiens_hsa049721.66270183
19ECM-receptor interaction_Homo sapiens_hsa045121.63460016
20Bile secretion_Homo sapiens_hsa049761.62485436
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58639272
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55202149
23Butanoate metabolism_Homo sapiens_hsa006501.52406688
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52096779
25Chronic myeloid leukemia_Homo sapiens_hsa052201.48228734
26Sulfur relay system_Homo sapiens_hsa041221.47152488
27Nicotine addiction_Homo sapiens_hsa050331.44694147
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44207144
29Endometrial cancer_Homo sapiens_hsa052131.38592108
30Glutamatergic synapse_Homo sapiens_hsa047241.38482362
31Basal cell carcinoma_Homo sapiens_hsa052171.36117874
32Fatty acid metabolism_Homo sapiens_hsa012121.35522650
33Hippo signaling pathway_Homo sapiens_hsa043901.34346437
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33714975
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33669399
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.33405713
37Synaptic vesicle cycle_Homo sapiens_hsa047211.33055770
38MicroRNAs in cancer_Homo sapiens_hsa052061.31509513
39Thyroid cancer_Homo sapiens_hsa052161.29547607
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28880696
41Ether lipid metabolism_Homo sapiens_hsa005651.26184460
42AMPK signaling pathway_Homo sapiens_hsa041521.25464152
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24522331
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23415590
45Sulfur metabolism_Homo sapiens_hsa009201.22255859
46Fructose and mannose metabolism_Homo sapiens_hsa000511.21154241
47Non-small cell lung cancer_Homo sapiens_hsa052231.19503875
48Histidine metabolism_Homo sapiens_hsa003401.19466741
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19324843
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17710530
51Fatty acid biosynthesis_Homo sapiens_hsa000611.17116485
52Glioma_Homo sapiens_hsa052141.16980091
53mTOR signaling pathway_Homo sapiens_hsa041501.16836350
54Small cell lung cancer_Homo sapiens_hsa052221.11203732
55Salivary secretion_Homo sapiens_hsa049701.10384125
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08783201
57Adherens junction_Homo sapiens_hsa045201.08463806
58Pancreatic cancer_Homo sapiens_hsa052121.08171860
59Phototransduction_Homo sapiens_hsa047441.07939753
60Lysine degradation_Homo sapiens_hsa003101.07864826
61Fat digestion and absorption_Homo sapiens_hsa049751.07798525
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07745149
63Hedgehog signaling pathway_Homo sapiens_hsa043401.07061288
64Propanoate metabolism_Homo sapiens_hsa006401.05191732
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04924665
66Morphine addiction_Homo sapiens_hsa050321.04307917
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04078659
68Gastric acid secretion_Homo sapiens_hsa049711.03515688
69Cyanoamino acid metabolism_Homo sapiens_hsa004601.03332499
70Arginine and proline metabolism_Homo sapiens_hsa003301.03316662
71Prostate cancer_Homo sapiens_hsa052151.01550385
72Melanogenesis_Homo sapiens_hsa049161.00838165
73Circadian entrainment_Homo sapiens_hsa047130.99799617
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98823782
75Focal adhesion_Homo sapiens_hsa045100.98375071
76Fatty acid degradation_Homo sapiens_hsa000710.96343231
77Cocaine addiction_Homo sapiens_hsa050300.96314887
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94685647
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94683926
80N-Glycan biosynthesis_Homo sapiens_hsa005100.94163747
81Cell cycle_Homo sapiens_hsa041100.92290004
82Insulin secretion_Homo sapiens_hsa049110.90146021
83PPAR signaling pathway_Homo sapiens_hsa033200.90070580
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.90021793
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89573784
86Renal cell carcinoma_Homo sapiens_hsa052110.89162726
87Tryptophan metabolism_Homo sapiens_hsa003800.88681128
88Vitamin digestion and absorption_Homo sapiens_hsa049770.86134790
89beta-Alanine metabolism_Homo sapiens_hsa004100.86127418
90Inositol phosphate metabolism_Homo sapiens_hsa005620.86094851
91Proteoglycans in cancer_Homo sapiens_hsa052050.85433810
92Protein digestion and absorption_Homo sapiens_hsa049740.84698640
93Insulin signaling pathway_Homo sapiens_hsa049100.84019141
94VEGF signaling pathway_Homo sapiens_hsa043700.83485705
95Melanoma_Homo sapiens_hsa052180.81558014
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81508666
97Choline metabolism in cancer_Homo sapiens_hsa052310.81487171
98Glycerolipid metabolism_Homo sapiens_hsa005610.81112510
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.80564694
100Wnt signaling pathway_Homo sapiens_hsa043100.79313780
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78408580
102Linoleic acid metabolism_Homo sapiens_hsa005910.77698039
103Peroxisome_Homo sapiens_hsa041460.77252738
104ABC transporters_Homo sapiens_hsa020100.77194304
105Chemical carcinogenesis_Homo sapiens_hsa052040.76522758
106Estrogen signaling pathway_Homo sapiens_hsa049150.76326509
107Olfactory transduction_Homo sapiens_hsa047400.74918398
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73116300
109Ovarian steroidogenesis_Homo sapiens_hsa049130.72916795
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72487815
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72440570
112Tight junction_Homo sapiens_hsa045300.69720088
113Long-term depression_Homo sapiens_hsa047300.69431256
114Complement and coagulation cascades_Homo sapiens_hsa046100.69327202
115Acute myeloid leukemia_Homo sapiens_hsa052210.68060713
116Axon guidance_Homo sapiens_hsa043600.67839727
117Retinol metabolism_Homo sapiens_hsa008300.66915428
118One carbon pool by folate_Homo sapiens_hsa006700.65325628
119Biosynthesis of amino acids_Homo sapiens_hsa012300.65189811
120Pyruvate metabolism_Homo sapiens_hsa006200.64388736
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64062404
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63915644
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63564354
124Carbon metabolism_Homo sapiens_hsa012000.63537727
125Mineral absorption_Homo sapiens_hsa049780.63455276
126Galactose metabolism_Homo sapiens_hsa000520.63164051
127Cholinergic synapse_Homo sapiens_hsa047250.61474780
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.61379200
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60952698
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.60903662
131Phenylalanine metabolism_Homo sapiens_hsa003600.60584725
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59828788
133Endocytosis_Homo sapiens_hsa041440.59490938
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59093142
135Dopaminergic synapse_Homo sapiens_hsa047280.58608849
136Folate biosynthesis_Homo sapiens_hsa007900.57779145
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57211802
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.57010479
1392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56271462
140Gap junction_Homo sapiens_hsa045400.56195550
141Glucagon signaling pathway_Homo sapiens_hsa049220.56061719
142Renin secretion_Homo sapiens_hsa049240.55832911
143mRNA surveillance pathway_Homo sapiens_hsa030150.55793215
144Serotonergic synapse_Homo sapiens_hsa047260.55447114
145Sphingolipid metabolism_Homo sapiens_hsa006000.55118007
146Pathways in cancer_Homo sapiens_hsa052000.54540010
147Amphetamine addiction_Homo sapiens_hsa050310.54067242
148cAMP signaling pathway_Homo sapiens_hsa040240.53954901
149Dorso-ventral axis formation_Homo sapiens_hsa043200.53288212
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51750136
151TGF-beta signaling pathway_Homo sapiens_hsa043500.51132297
152Hepatitis C_Homo sapiens_hsa051600.51025522
153Long-term potentiation_Homo sapiens_hsa047200.50269396
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49520197
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.48554658
156Thyroid hormone synthesis_Homo sapiens_hsa049180.48492198
157Vibrio cholerae infection_Homo sapiens_hsa051100.47178313
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.44207589
159GnRH signaling pathway_Homo sapiens_hsa049120.43497237
160Taste transduction_Homo sapiens_hsa047420.39861859
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.38970680
162Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38666884
163Calcium signaling pathway_Homo sapiens_hsa040200.37993880
164Collecting duct acid secretion_Homo sapiens_hsa049660.36922677
165Prion diseases_Homo sapiens_hsa050200.36162335
166Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34091665
167Tyrosine metabolism_Homo sapiens_hsa003500.33167673
168ErbB signaling pathway_Homo sapiens_hsa040120.32339904

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