SLC7A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.12069369
2desmosome organization (GO:0002934)4.94404848
3mitotic chromosome condensation (GO:0007076)4.45371797
4Golgi transport vesicle coating (GO:0048200)4.33097194
5COPI coating of Golgi vesicle (GO:0048205)4.33097194
6cellular protein complex localization (GO:0034629)4.11865568
7cell-substrate junction assembly (GO:0007044)3.95388429
8nuclear pore complex assembly (GO:0051292)3.86531617
9regulation of translational fidelity (GO:0006450)3.77297211
10protein complex localization (GO:0031503)3.76224971
11proline biosynthetic process (GO:0006561)3.68182080
12skin morphogenesis (GO:0043589)3.65107067
13adherens junction assembly (GO:0034333)3.60467899
14focal adhesion assembly (GO:0048041)3.58537628
15cell-substrate adherens junction assembly (GO:0007045)3.58537628
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.56507957
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.52398063
18activation of Rac GTPase activity (GO:0032863)3.42083336
19nuclear pore organization (GO:0006999)3.41907288
20regulation of mammary gland epithelial cell proliferation (GO:0033599)3.23759397
21planar cell polarity pathway involved in neural tube closure (GO:0090179)3.21909574
22protein retention in ER lumen (GO:0006621)3.18144112
23L-serine metabolic process (GO:0006563)3.18127406
24protein localization to chromosome, centromeric region (GO:0071459)3.16694686
25mitotic sister chromatid segregation (GO:0000070)3.15183128
26regulation of nucleobase-containing compound transport (GO:0032239)3.04074440
27spliceosomal tri-snRNP complex assembly (GO:0000244)3.01202808
28regulation of glucose import in response to insulin stimulus (GO:2001273)2.98369706
29positive thymic T cell selection (GO:0045059)2.98033308
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97554539
31protein localization to microtubule (GO:0035372)2.96372512
32cytoskeletal anchoring at plasma membrane (GO:0007016)2.89998790
33germ cell migration (GO:0008354)2.87337815
34lymph vessel development (GO:0001945)2.85831376
35epithelial cell-cell adhesion (GO:0090136)2.85074864
36protein export from nucleus (GO:0006611)2.83333682
37branching involved in mammary gland duct morphogenesis (GO:0060444)2.82583312
38vascular endothelial growth factor signaling pathway (GO:0038084)2.81966200
39chromosome condensation (GO:0030261)2.81630351
40pore complex assembly (GO:0046931)2.78374286
41regulation of early endosome to late endosome transport (GO:2000641)2.77890538
42cytoplasmic mRNA processing body assembly (GO:0033962)2.74959748
43regulation of water loss via skin (GO:0033561)2.74448601
44DNA strand elongation (GO:0022616)2.73300750
45DNA unwinding involved in DNA replication (GO:0006268)2.72853123
46endothelium development (GO:0003158)2.72819075
47ER-nucleus signaling pathway (GO:0006984)2.71816116
48endoplasmic reticulum unfolded protein response (GO:0030968)2.71422352
49folic acid-containing compound biosynthetic process (GO:0009396)2.71054094
50gap junction assembly (GO:0016264)2.70748112
51retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.70444343
52DNA strand elongation involved in DNA replication (GO:0006271)2.68598893
53regulation of histone H3-K27 methylation (GO:0061085)2.67616984
54dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.66745324
55L-alpha-amino acid transmembrane transport (GO:1902475)2.65029133
56regulation of translational termination (GO:0006449)2.64688816
57ER overload response (GO:0006983)2.64220339
58apoptotic process involved in morphogenesis (GO:0060561)2.63406599
59mitotic G1 DNA damage checkpoint (GO:0031571)2.62263478
60DNA replication initiation (GO:0006270)2.61463335
61corticosteroid receptor signaling pathway (GO:0031958)2.58998758
62histone H3-K36 demethylation (GO:0070544)2.57732807
63bundle of His cell to Purkinje myocyte communication (GO:0086069)2.57428647
64G1 DNA damage checkpoint (GO:0044783)2.56566336
65COPII vesicle coating (GO:0048208)2.56172913
66cellular response to epidermal growth factor stimulus (GO:0071364)2.55042661
67negative regulation of keratinocyte proliferation (GO:0010839)2.53911634
68L-serine transport (GO:0015825)2.52980879
69regulation of nuclease activity (GO:0032069)2.52815118
70protein localization to endosome (GO:0036010)2.51331853
71cellular response to unfolded protein (GO:0034620)2.51280957
72positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49708085
73mRNA transcription (GO:0009299)2.49634563
74mRNA transcription from RNA polymerase II promoter (GO:0042789)2.46686008
75regulation of mitotic spindle organization (GO:0060236)2.46177104
76positive regulation of chromosome segregation (GO:0051984)2.44981921
77formation of translation preinitiation complex (GO:0001731)2.44922157
78intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.44423955
79NLS-bearing protein import into nucleus (GO:0006607)2.43998834
80DNA geometric change (GO:0032392)2.43548796
81pre-miRNA processing (GO:0031054)2.43042876
82vesicle coating (GO:0006901)2.42032464
83endoderm formation (GO:0001706)2.41761436
84alternative mRNA splicing, via spliceosome (GO:0000380)2.41006857
85mitotic nuclear envelope reassembly (GO:0007084)2.40015275
86nuclear envelope reassembly (GO:0031468)2.40015275
87serine transport (GO:0032329)2.39319251
88heterochromatin organization (GO:0070828)2.39316410
89protein localization to kinetochore (GO:0034501)2.39281370
90mitotic sister chromatid cohesion (GO:0007064)2.37842731
91maternal placenta development (GO:0001893)2.37651904
92regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.37592425
93cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.36654074
94trophectodermal cell differentiation (GO:0001829)2.36546337
95positive regulation of keratinocyte differentiation (GO:0045618)2.36351077
96positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.36269237
97mammary gland epithelial cell proliferation (GO:0033598)2.35060451
98positive regulation of gamma-delta T cell activation (GO:0046645)2.34850512
99embryonic eye morphogenesis (GO:0048048)2.34511415
100positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34363504
101embryonic foregut morphogenesis (GO:0048617)2.33359053
102cell migration involved in sprouting angiogenesis (GO:0002042)2.32653778
103peptidyl-tyrosine autophosphorylation (GO:0038083)2.31243800
104male sex determination (GO:0030238)2.30789081
105positive T cell selection (GO:0043368)2.29024667
106mitotic nuclear envelope disassembly (GO:0007077)2.24043043
107hippo signaling (GO:0035329)2.20267691
108thymic T cell selection (GO:0045061)2.20172228
109nuclear envelope disassembly (GO:0051081)2.19695078
110membrane disassembly (GO:0030397)2.19695078
111positive regulation of endothelial cell apoptotic process (GO:2000353)2.19069749
112positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.18534246
113RNA stabilization (GO:0043489)2.18481949
114mRNA stabilization (GO:0048255)2.18481949
115mesodermal cell differentiation (GO:0048333)2.16529454
116regulation of NFAT protein import into nucleus (GO:0051532)2.15636134
117regulation of gamma-delta T cell differentiation (GO:0045586)2.13375518
118negative regulation of glial cell proliferation (GO:0060253)2.12441754
119response to laminar fluid shear stress (GO:0034616)2.12249365
120ventricular trabecula myocardium morphogenesis (GO:0003222)2.11993886
121sister chromatid segregation (GO:0000819)2.11208817
122negative regulation of mRNA metabolic process (GO:1903312)2.10625642
123glucocorticoid receptor signaling pathway (GO:0042921)2.10500482
124positive regulation of astrocyte differentiation (GO:0048711)2.09940392
125chromatin assembly (GO:0031497)2.08700884
126histone lysine demethylation (GO:0070076)2.08622852
127viral transcription (GO:0019083)2.07601154
128patterning of blood vessels (GO:0001569)2.07566471
129negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.07186129
130regulation of translational elongation (GO:0006448)2.07097302
131maturation of SSU-rRNA (GO:0030490)2.06345259
132cell adhesion mediated by integrin (GO:0033627)2.06311546
133retina vasculature morphogenesis in camera-type eye (GO:0061299)2.05891905
134translational termination (GO:0006415)2.05740863
135negative regulation of RNA splicing (GO:0033119)2.05274433
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.04962542
137establishment of apical/basal cell polarity (GO:0035089)2.04714417
138cellular response to nicotine (GO:0071316)2.04440870
139peptidyl-arginine omega-N-methylation (GO:0035247)2.04189081
140coronary vasculature morphogenesis (GO:0060977)2.03947203
141Notch signaling involved in heart development (GO:0061314)2.03169308
142histone demethylation (GO:0016577)2.02351146
143trabecula morphogenesis (GO:0061383)2.01937592
144formation of primary germ layer (GO:0001704)1.99839990
145positive regulation of odontogenesis (GO:0042482)1.99408065
146regulation of vitamin D biosynthetic process (GO:0060556)1.98399767
147positive regulation of histone deacetylation (GO:0031065)1.98113456
148dosage compensation (GO:0007549)1.97715429
149radial glial cell differentiation (GO:0060019)1.97540503
150embryonic process involved in female pregnancy (GO:0060136)1.96557859
151positive regulation of dendritic spine morphogenesis (GO:0061003)1.96476439
152polarized epithelial cell differentiation (GO:0030859)1.96287728
153response to fluid shear stress (GO:0034405)1.96182706
154establishment or maintenance of monopolar cell polarity (GO:0061339)1.96041641
155establishment of monopolar cell polarity (GO:0061162)1.96041641
156histone H2A monoubiquitination (GO:0035518)1.95967199
157negative regulation of mRNA processing (GO:0050686)1.95406177
158DNA duplex unwinding (GO:0032508)1.95108531
159peptidyl-arginine N-methylation (GO:0035246)1.94551829
160peptidyl-arginine methylation (GO:0018216)1.94551829
161negative thymic T cell selection (GO:0045060)1.94475847
162establishment of endothelial barrier (GO:0061028)1.92600942
163developmental programmed cell death (GO:0010623)1.92258597
164positive regulation of nuclease activity (GO:0032075)1.92082360
165activation of signaling protein activity involved in unfolded protein response (GO:0006987)1.92043547
166regulation of RNA export from nucleus (GO:0046831)1.91968513
167tyrosine phosphorylation of STAT protein (GO:0007260)1.91464136
168T cell apoptotic process (GO:0070231)1.91331267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.22861712
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.36207634
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.12456358
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12027845
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.05550223
6MYC_22102868_ChIP-Seq_BL_Human3.54251620
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.53503688
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.31907755
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.17131421
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.45145000
11ZNF263_19887448_ChIP-Seq_K562_Human2.43692583
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36521122
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14738140
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09890812
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.06067602
16KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98267432
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96544416
18* TCF7_22412390_ChIP-Seq_EML_Mouse1.95668799
19KDM2B_26808549_Chip-Seq_DND41_Human1.94809997
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92999023
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89421888
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.89162407
23* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88952674
24CLOCK_20551151_ChIP-Seq_293T_Human1.88222063
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.87785686
26* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85184902
27VDR_21846776_ChIP-Seq_THP-1_Human1.83052133
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81770441
29* MYC_18555785_ChIP-Seq_MESCs_Mouse1.80185946
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79043921
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71353827
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69951516
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69406845
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.67866701
35* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65984709
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64910988
37ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63016374
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.60930215
39KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59980066
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.56659062
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52663311
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49095478
43TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48631469
44LXR_22292898_ChIP-Seq_THP-1_Human1.46932642
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45940711
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44606764
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43435046
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42955568
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42934911
50MAF_26560356_Chip-Seq_TH1_Human1.42469005
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42100642
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41974448
53UTX_26944678_Chip-Seq_JUKART_Human1.41278503
54RUNX_20019798_ChIP-Seq_JUKART_Human1.41058742
55* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40994273
56* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40994273
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39480647
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38702782
59MYB_26560356_Chip-Seq_TH2_Human1.38556797
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38020911
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37903128
62KDM2B_26808549_Chip-Seq_K562_Human1.37116476
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36700260
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35405872
65* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34514173
66* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32716419
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31278175
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31133516
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.29700735
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27596981
71* ATF3_27146783_Chip-Seq_COLON_Human1.27448839
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.25924434
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25679756
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25677331
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25304995
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22301238
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21376714
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21376714
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21376714
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20524418
81MYB_26560356_Chip-Seq_TH1_Human1.20442976
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19648411
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.19452121
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18266235
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18099911
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17735380
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15365093
88VDR_24763502_ChIP-Seq_THP-1_Human1.15245536
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14297491
90FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11970565
91* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10745944
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.10497554
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10370566
94MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09861168
95* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09077312
96NCOR1_26117541_ChIP-Seq_K562_Human1.08671371
97* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07844334
98* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07158156
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06703736
100DCP1A_22483619_ChIP-Seq_HELA_Human1.06056463
101* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05613889
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05392049
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03747724
104CHD1_26751641_Chip-Seq_LNCaP_Human1.03068876
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03059736
106* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02290463
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02202251
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01882558
109AR_21909140_ChIP-Seq_LNCAP_Human1.01158559
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00506922
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00191661
112* BRD4_25478319_ChIP-Seq_HGPS_Human0.97790056
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97212570
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97083164
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96161556
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95263522
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94494617
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94072316
119* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94069892
120CREB1_26743006_Chip-Seq_LNCaP_Human0.94050156
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93519107
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93348541
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93285042
124* RACK7_27058665_Chip-Seq_MCF-7_Human0.93152566
125TP53_22127205_ChIP-Seq_IMR90_Human0.92348245
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91718055
127TP63_19390658_ChIP-ChIP_HaCaT_Human0.91158587
128THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91109485
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90837340
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.90556082
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90521059
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89983677
133* RUNX1_22412390_ChIP-Seq_EML_Mouse0.89464864
134SCL_19346495_ChIP-Seq_HPC-7_Human0.89323744
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86675296
136GATA6_25053715_ChIP-Seq_YYC3_Human0.86596446
137CIITA_25753668_ChIP-Seq_RAJI_Human0.86283707
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86014873
139* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85416808
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.83633265
141TTF2_22483619_ChIP-Seq_HELA_Human0.82683740
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82428776
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81701165
144ISL1_27105846_Chip-Seq_CPCs_Mouse0.81565498
145XRN2_22483619_ChIP-Seq_HELA_Human0.81299736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology2.79258178
2MP0008438_abnormal_cutaneous_collagen2.69579038
3MP0002796_impaired_skin_barrier2.59910899
4MP0003300_gastrointestinal_ulcer2.58802565
5MP0010352_gastrointestinal_tract_polyps2.49126970
6MP0003303_peritoneal_inflammation2.42301809
7MP0000579_abnormal_nail_morphology2.38297067
8MP0005076_abnormal_cell_differentiation2.36298070
9MP0005501_abnormal_skin_physiology2.06252283
10MP0002060_abnormal_skin_morphology2.03443975
11MP0001849_ear_inflammation1.97432666
12MP0003453_abnormal_keratinocyte_physiol1.95841642
13MP0004808_abnormal_hematopoietic_stem1.92974843
14MP0004272_abnormal_basement_membrane1.88821362
15MP0004185_abnormal_adipocyte_glucose1.87865914
16MP0003566_abnormal_cell_adhesion1.86102873
17MP0002877_abnormal_melanocyte_morpholog1.85693953
18MP0008057_abnormal_DNA_replication1.79758819
19MP0009278_abnormal_bone_marrow1.74961006
20MP0005409_darkened_coat_color1.74032895
21MP0002396_abnormal_hematopoietic_system1.69429105
22MP0003091_abnormal_cell_migration1.66626287
23MP0005171_absent_coat_pigmentation1.65355615
24MP0000733_abnormal_muscle_development1.63377022
25MP0003763_abnormal_thymus_physiology1.61709703
26MP0004264_abnormal_extraembryonic_tissu1.60358058
27MP0001216_abnormal_epidermal_layer1.60016108
28MP0005451_abnormal_body_composition1.58547181
29MP0005275_abnormal_skin_tensile1.52271221
30MP0000762_abnormal_tongue_morphology1.50264787
31MP0004858_abnormal_nervous_system1.48540551
32MP0006054_spinal_hemorrhage1.47595894
33MP0000569_abnormal_digit_pigmentation1.43707487
34MP0009672_abnormal_birth_weight1.43582011
35MP0001873_stomach_inflammation1.41779478
36MP0003705_abnormal_hypodermis_morpholog1.40049959
37MP0008961_abnormal_basal_metabolism1.38395265
38MP0000350_abnormal_cell_proliferation1.35689709
39MP0003984_embryonic_growth_retardation1.34803632
40MP0000467_abnormal_esophagus_morphology1.34219701
41MP0010094_abnormal_chromosome_stability1.34211242
42MP0003111_abnormal_nucleus_morphology1.33412335
43MP0002088_abnormal_embryonic_growth/wei1.32376145
44MP0004197_abnormal_fetal_growth/weight/1.32241977
45MP0001879_abnormal_lymphatic_vessel1.31628127
46MP0000566_synostosis1.31484772
47MP0001730_embryonic_growth_arrest1.30136611
48MP0002086_abnormal_extraembryonic_tissu1.29775578
49MP0002084_abnormal_developmental_patter1.28941095
50MP0004957_abnormal_blastocyst_morpholog1.28800202
51MP0002098_abnormal_vibrissa_morphology1.28376900
52MP0002925_abnormal_cardiovascular_devel1.27644196
53MP0000703_abnormal_thymus_morphology1.27180624
54MP0001672_abnormal_embryogenesis/_devel1.25246307
55MP0005380_embryogenesis_phenotype1.25246307
56MP0000537_abnormal_urethra_morphology1.23716909
57MP0002166_altered_tumor_susceptibility1.19552278
58MP0002009_preneoplasia1.19485401
59MP0003077_abnormal_cell_cycle1.18762218
60MP0009053_abnormal_anal_canal1.17645360
61MP0000377_abnormal_hair_follicle1.16130805
62MP0002405_respiratory_system_inflammati1.15209097
63MP0010771_integument_phenotype1.12770519
64* MP0005621_abnormal_cell_physiology1.12662029
65MP0002085_abnormal_embryonic_tissue1.10296620
66MP0001697_abnormal_embryo_size1.09685131
67MP0010307_abnormal_tumor_latency1.09458727
68MP0003866_abnormal_defecation1.07754178
69MP0000003_abnormal_adipose_tissue1.07161136
70MP0000678_abnormal_parathyroid_gland1.06529405
71MP0003279_aneurysm1.04851426
72MP0002933_joint_inflammation1.04364516
73MP0001915_intracranial_hemorrhage1.04122224
74MP0009931_abnormal_skin_appearance1.02852969
75MP0003115_abnormal_respiratory_system1.02735226
76MP0001348_abnormal_lacrimal_gland1.02646410
77MP0000627_abnormal_mammary_gland1.01469614
78MP0003693_abnormal_embryo_hatching0.98880367
79* MP0002398_abnormal_bone_marrow0.98426371
80MP0003941_abnormal_skin_development0.98339753
81MP0003942_abnormal_urinary_system0.98153775
82MP0000490_abnormal_crypts_of0.97812064
83MP0010030_abnormal_orbit_morphology0.97688494
84MP0003045_fibrosis0.96309799
85MP0004947_skin_inflammation0.95990297
86MP0002089_abnormal_postnatal_growth/wei0.95650700
87MP0002080_prenatal_lethality0.95032766
88MP0003315_abnormal_perineum_morphology0.94997617
89MP0000534_abnormal_ureter_morphology0.94804075
90MP0008007_abnormal_cellular_replicative0.93704692
91MP0010630_abnormal_cardiac_muscle0.92934374
92MP0009333_abnormal_splenocyte_physiolog0.92547069
93MP0004782_abnormal_surfactant_physiolog0.91839312
94MP0005377_hearing/vestibular/ear_phenot0.91696905
95MP0003878_abnormal_ear_physiology0.91696905
96MP0009384_cardiac_valve_regurgitation0.91613509
97MP0003123_paternal_imprinting0.91494051
98MP0003950_abnormal_plasma_membrane0.90592031
99MP0003935_abnormal_craniofacial_develop0.90322763
100MP0004084_abnormal_cardiac_muscle0.88798187
101MP0000858_altered_metastatic_potential0.88368423
102MP0001784_abnormal_fluid_regulation0.86696913
103MP0005408_hypopigmentation0.86049447
104MP0005167_abnormal_blood-brain_barrier0.85330912
105MP0002697_abnormal_eye_size0.83118745
106MP0000372_irregular_coat_pigmentation0.82852107
107MP0002006_tumorigenesis0.82101302
108* MP0005384_cellular_phenotype0.81531405
109MP0005023_abnormal_wound_healing0.81414518
110MP0001299_abnormal_eye_distance/0.79791934
111MP0005397_hematopoietic_system_phenotyp0.79495717
112MP0001545_abnormal_hematopoietic_system0.79495717
113MP0000383_abnormal_hair_follicle0.79448641
114MP0000015_abnormal_ear_pigmentation0.78297218
115MP0004233_abnormal_muscle_weight0.77721367
116MP0001243_abnormal_dermal_layer0.77436091
117MP0002722_abnormal_immune_system0.77294122
118MP0003890_abnormal_embryonic-extraembry0.76914746
119MP0000432_abnormal_head_morphology0.76267626
120MP0001661_extended_life_span0.76136625
121MP0002896_abnormal_bone_mineralization0.75978232
122MP0003121_genomic_imprinting0.75561834
123MP0003828_pulmonary_edema0.74953631
124MP0000767_abnormal_smooth_muscle0.74912552
125MP0005257_abnormal_intraocular_pressure0.74905845
126MP0008932_abnormal_embryonic_tissue0.74768140
127MP0002113_abnormal_skeleton_development0.74337691
128MP0000266_abnormal_heart_morphology0.74283100
129MP0003943_abnormal_hepatobiliary_system0.73664409
130MP0001340_abnormal_eyelid_morphology0.73614199
131MP0003448_altered_tumor_morphology0.73529799
132MP0005375_adipose_tissue_phenotype0.73275414
133MP0008770_decreased_survivor_rate0.72363281
134MP0001881_abnormal_mammary_gland0.72156493
135MP0001800_abnormal_humoral_immune0.71630568
136MP0005666_abnormal_adipose_tissue0.71533070
137MP0000428_abnormal_craniofacial_morphol0.70749841
138MP0010678_abnormal_skin_adnexa0.68995304
139MP0005387_immune_system_phenotype0.68234133
140MP0001790_abnormal_immune_system0.68234133
141MP0004484_altered_response_of0.68071589
142MP0000685_abnormal_immune_system0.67912216
143MP0000313_abnormal_cell_death0.67496441
144MP0010234_abnormal_vibrissa_follicle0.67246021
145MP0002116_abnormal_craniofacial_bone0.66960787

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)3.38297389
2Insomnia (HP:0100785)2.86360767
3Persistence of primary teeth (HP:0006335)2.79573321
4Broad face (HP:0000283)2.73445556
5Adactyly (HP:0009776)2.67413714
6Fragile skin (HP:0001030)2.66768389
7Shallow orbits (HP:0000586)2.51772832
8Absent hand (HP:0004050)2.51353988
9Epiphyseal dysplasia (HP:0002656)2.51210354
10Onycholysis (HP:0001806)2.47282801
11Advanced eruption of teeth (HP:0006288)2.41394745
12Subacute progressive viral hepatitis (HP:0006572)2.38593595
13Upper limb muscle weakness (HP:0003484)2.34904900
14Natal tooth (HP:0000695)2.33255517
15Fragile nails (HP:0001808)2.31970268
16Long palpebral fissure (HP:0000637)2.31494851
17Abnormality of nail color (HP:0100643)2.28938148
18Hand muscle atrophy (HP:0009130)2.28316174
19Asymmetry of the thorax (HP:0001555)2.26280696
20Skull defect (HP:0001362)2.26064797
21Deviation of the thumb (HP:0009603)2.23038060
22Trismus (HP:0000211)2.19407880
23Increased nuchal translucency (HP:0010880)2.16709474
24Distal upper limb amyotrophy (HP:0007149)2.16071649
25Upper limb amyotrophy (HP:0009129)2.16071649
26Septate vagina (HP:0001153)2.15866664
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.15195438
28Osteolytic defects of the hand bones (HP:0009699)2.15195438
29Dysmetric saccades (HP:0000641)2.14903076
30Abnormality of the distal phalanx of the thumb (HP:0009617)2.14025524
31Disproportionate tall stature (HP:0001519)2.13801725
32Hypoplastic ischia (HP:0003175)2.13627204
33Achilles tendon contracture (HP:0001771)2.12337669
34Short nail (HP:0001799)2.10664534
35Pterygium (HP:0001059)2.10619208
36Ridged nail (HP:0001807)2.08458365
37Hyperacusis (HP:0010780)2.08147964
38Proximal placement of thumb (HP:0009623)2.07569213
39Cerebral aneurysm (HP:0004944)2.07330227
40Sparse lateral eyebrow (HP:0005338)2.04764883
41Termporal pattern (HP:0011008)2.01439474
42Insidious onset (HP:0003587)2.01439474
43Glossoptosis (HP:0000162)1.99625260
44Urethral obstruction (HP:0000796)1.98354651
45Spinal cord lesions (HP:0100561)1.98167993
46Syringomyelia (HP:0003396)1.98167993
47Right ventricular cardiomyopathy (HP:0011663)1.96557093
48Distal lower limb amyotrophy (HP:0008944)1.94501326
49Overriding aorta (HP:0002623)1.93196199
50Ankle contracture (HP:0006466)1.92176141
51Vertebral compression fractures (HP:0002953)1.91798413
52Small epiphyses (HP:0010585)1.91500995
53Premature rupture of membranes (HP:0001788)1.91365431
54Plantar hyperkeratosis (HP:0007556)1.88371915
55Abnormality of the umbilical cord (HP:0010881)1.88287787
56Nail dystrophy (HP:0008404)1.88254701
57Aortic aneurysm (HP:0004942)1.86356993
58Biconcave vertebral bodies (HP:0004586)1.86158664
59Protrusio acetabuli (HP:0003179)1.85585032
60Arterial tortuosity (HP:0005116)1.85303009
61Abnormality of oral frenula (HP:0000190)1.84311903
62Patellar dislocation (HP:0002999)1.84305869
63Absent eyelashes (HP:0000561)1.83200926
64Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82628481
65Abnormality of the Achilles tendon (HP:0005109)1.81686605
66Spinal rigidity (HP:0003306)1.81308467
67Abnormality of the distal phalanges of the toes (HP:0010182)1.80450793
68Absent frontal sinuses (HP:0002688)1.80264708
69Abnormal ossification of hand bones (HP:0005921)1.79782332
70IgA deficiency (HP:0002720)1.78795125
71Elbow flexion contracture (HP:0002987)1.78496316
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78017321
73Macroorchidism (HP:0000053)1.77937465
74Abnormal vertebral ossification (HP:0100569)1.77643545
75Abnormality of carpal bone ossification (HP:0006257)1.77295396
76Vascular tortuosity (HP:0004948)1.77116422
77Somatic mutation (HP:0001428)1.76146027
78Back pain (HP:0003418)1.75924040
79Progressive muscle weakness (HP:0003323)1.75664048
80Ankyloglossia (HP:0010296)1.74416277
81Arnold-Chiari malformation (HP:0002308)1.74182818
82Missing ribs (HP:0000921)1.73669443
83Abnormality of the ischium (HP:0003174)1.73524342
84Aplasia cutis congenita (HP:0001057)1.73441870
85Obstructive sleep apnea (HP:0002870)1.73282417
86Heterotopia (HP:0002282)1.73216520
87Chromsome breakage (HP:0040012)1.72569183
88Relative macrocephaly (HP:0004482)1.72179707
89Mitral regurgitation (HP:0001653)1.72049494
90Abnormality of the salivary glands (HP:0010286)1.71569367
91Lower limb amyotrophy (HP:0007210)1.71483955
92Blue sclerae (HP:0000592)1.69795011
93Abnormality of the phalanges of the hallux (HP:0010057)1.69563378
94Deep philtrum (HP:0002002)1.69554085
95Porencephaly (HP:0002132)1.68859241
96Cervical subluxation (HP:0003308)1.67059752
97Flat acetabular roof (HP:0003180)1.64727839
98Abnormality of the calcaneus (HP:0008364)1.64320125
99Spinal cord compression (HP:0002176)1.63868378
100Breast hypoplasia (HP:0003187)1.63500301
101Smooth philtrum (HP:0000319)1.63037009
102Thoracolumbar scoliosis (HP:0002944)1.62857398
103Bowel diverticulosis (HP:0005222)1.62732932
104Genu recurvatum (HP:0002816)1.62569306
105Fatigue (HP:0012378)1.62071791
106Aortic dissection (HP:0002647)1.60997144
107Bicuspid aortic valve (HP:0001647)1.60806265
108Milia (HP:0001056)1.60256806
109Short 4th metacarpal (HP:0010044)1.59605082
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59605082
111Overlapping toe (HP:0001845)1.59602188
112Alopecia of scalp (HP:0002293)1.59266114
113Abnormality of the fingertips (HP:0001211)1.59118415
114Mildly elevated creatine phosphokinase (HP:0008180)1.59043260
115Pili torti (HP:0003777)1.58906050
116Abnormality of the peritoneum (HP:0002585)1.57836634
117Hypoplastic toenails (HP:0001800)1.57753713
118Vertebral arch anomaly (HP:0008438)1.56759679
119Limited elbow extension (HP:0001377)1.56127755
120Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55577284
121Selective tooth agenesis (HP:0001592)1.53879842
122Ulnar bowing (HP:0003031)1.53507471
123Leiomyosarcoma (HP:0100243)1.53148318
124Uterine leiomyosarcoma (HP:0002891)1.53148318
125Thrombocytosis (HP:0001894)1.52307414
126Wormian bones (HP:0002645)1.51817973
127Astrocytoma (HP:0009592)1.51736069
128Abnormality of the astrocytes (HP:0100707)1.51736069
129Mitral valve prolapse (HP:0001634)1.51239481
130Dilatation of the ascending aorta (HP:0005111)1.51117073
131Malignant gastrointestinal tract tumors (HP:0006749)1.50996707
132Gastrointestinal carcinoma (HP:0002672)1.50996707
133Transitional cell carcinoma of the bladder (HP:0006740)1.50123732
134Amaurosis fugax (HP:0100576)1.49427090
135Broad palm (HP:0001169)1.48506150
136Metaphyseal cupping (HP:0003021)1.47687021
137Atrophic scars (HP:0001075)1.47550434
138Radial bowing (HP:0002986)1.46428879
139Bladder diverticulum (HP:0000015)1.46365406
140Vertebral hypoplasia (HP:0008417)1.45608548
141Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.45608548
142Esophageal atresia (HP:0002032)1.44815756
143Elfin facies (HP:0004428)1.44736856
144Severe short stature (HP:0003510)1.44675796
145Mild short stature (HP:0003502)1.44407201
146Chin dimple (HP:0010751)1.43306337
147Hypoplasia of the iris (HP:0007676)1.42976883
14811 pairs of ribs (HP:0000878)1.41494062
149Cutis marmorata (HP:0000965)1.40480028
150Difficulty climbing stairs (HP:0003551)1.40453073
151Abnormality of the right ventricle (HP:0001707)1.39624012
152Bladder neoplasm (HP:0009725)1.38587946
153Bladder carcinoma (HP:0002862)1.38587946
154Ependymoma (HP:0002888)1.37820063
155Thick nail (HP:0001805)1.37794151
156Basal cell carcinoma (HP:0002671)1.37668604
157Renal duplication (HP:0000075)1.37498044
158Ureteral stenosis (HP:0000071)1.36648395
159Irregular epiphyses (HP:0010582)1.36027571
160Abnormality of the gastric mucosa (HP:0004295)1.35903341
161Long eyelashes (HP:0000527)1.35885297
162Supernumerary ribs (HP:0005815)1.35854758
163Stomatitis (HP:0010280)1.35782597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.68995954
2CDK124.37724000
3SMG13.89250083
4IRAK33.15238839
5PKN22.53975465
6MAP4K12.50787468
7TRIB32.43813077
8MST1R2.38347198
9PRPF4B2.36401720
10LATS22.07217010
11BRD41.99023466
12ALK1.88579864
13MAP3K101.87933653
14KDR1.85098179
15EPHA21.78856287
16MST41.76164681
17TAOK11.71657687
18TTN1.62989877
19RPS6KB21.62787217
20LMTK21.59319441
21JAK31.56858330
22SIK21.52984635
23SCYL21.48837766
24PAK21.48696584
25STK101.48258117
26BMX1.47658635
27DMPK1.45778112
28MTOR1.43015728
29MET1.39630879
30TAF11.38545680
31TSSK61.37012520
32CAMK1D1.36061654
33LRRK21.35439321
34PIM21.35268628
35PRKD31.28453621
36ERN11.26676427
37ZAP701.25988385
38TYRO31.25751288
39CHUK1.24965754
40PDGFRA1.22786137
41TTK1.22648524
42FGFR41.22478198
43NME21.21382263
44CDC71.17856036
45PTK61.16594554
46LATS11.14946712
47PASK1.13157447
48ITK1.12785476
49MAP3K91.12327347
50NTRK11.09997985
51AKT31.09934446
52EIF2AK11.09500399
53BUB11.06384163
54TGFBR11.04288235
55MAP3K31.04016653
56STK31.03054862
57DDR20.99788910
58NEK20.96072287
59EPHB10.95099501
60PDGFRB0.94490700
61MARK30.91768060
62SIK30.91078136
63ICK0.89169554
64TRPM70.89092653
65CHEK10.88685079
66PIM10.88484146
67MAP3K110.86720933
68TXK0.86313411
69ARAF0.85370114
70MAP3K80.84714024
71RPS6KA40.83295307
72CHEK20.83021187
73CDK40.82420819
74CDK70.82094162
75MELK0.80933472
76TIE10.80913556
77CDK80.80747748
78CDK90.79884002
79MARK20.79660992
80ERBB40.76786062
81WNK10.74797733
82MAP3K140.73303359
83NUAK10.72706077
84HCK0.71199097
85EPHA30.70124478
86CDK60.69859651
87STK240.69453602
88MAP3K130.68641792
89PRKG20.67226683
90INSR0.66291692
91VRK20.66059675
92MAPKAPK30.65220402
93FGR0.65034853
94EGFR0.63550221
95CSK0.63289666
96IRAK20.63224218
97KSR20.63114548
98CDC42BPA0.62229901
99MAP2K30.62017345
100PTK2B0.61586668
101PAK40.61023168
102RET0.60978856
103SRPK10.60577509
104NLK0.60140294
105SIK10.59843210
106RIPK10.58967838
107MAPK110.58645573
108NEK10.58434308
109NEK90.56865098
110CSNK1D0.56267622
111ATM0.55570262
112NTRK20.55500927
113ROCK20.55449622
114CLK10.54561545
115RPS6KA20.54300675
116CAMK1G0.53865828
117FGFR30.53659577
118BRAF0.53560454
119PTK20.53311940
120PRKD20.52770903
121AURKB0.52597632
122WEE10.52305525
123IKBKB0.51821292
124PNCK0.50827948
125MAPKAPK20.48431234
126CDK20.48177819
127RPS6KA10.47663621
128TEC0.47144918
129MAP2K20.47131401
130AKT20.46689898
131HIPK20.46396070
132LCK0.45929974
133CSNK1A1L0.45855711
134GSK3A0.45370372
135AURKA0.44690740
136BRSK10.44324110
137FGFR10.43341000
138TAOK20.43311183
139EPHB20.43114517
140MOS0.42365129
141ATR0.41943674
142EIF2AK20.39390128
143CDK10.38638075
144TESK10.38361127
145ILK0.37298369

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.25480873
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77347869
3Chronic myeloid leukemia_Homo sapiens_hsa052201.67527709
4Small cell lung cancer_Homo sapiens_hsa052221.55169309
5Biosynthesis of amino acids_Homo sapiens_hsa012301.51784852
6Adherens junction_Homo sapiens_hsa045201.45050507
7T cell receptor signaling pathway_Homo sapiens_hsa046601.39556888
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36118544
9Viral myocarditis_Homo sapiens_hsa054161.32488691
10Vitamin B6 metabolism_Homo sapiens_hsa007501.30210673
11* MicroRNAs in cancer_Homo sapiens_hsa052061.29962594
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.29405370
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29126255
14Focal adhesion_Homo sapiens_hsa045101.28173578
15Prion diseases_Homo sapiens_hsa050201.22552241
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21735072
17HTLV-I infection_Homo sapiens_hsa051661.21696741
18ECM-receptor interaction_Homo sapiens_hsa045121.21441699
19Notch signaling pathway_Homo sapiens_hsa043301.21007907
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20528982
21Toxoplasmosis_Homo sapiens_hsa051451.18468803
22Acute myeloid leukemia_Homo sapiens_hsa052211.17236887
23HIF-1 signaling pathway_Homo sapiens_hsa040661.13317010
24Colorectal cancer_Homo sapiens_hsa052101.12940020
25Prostate cancer_Homo sapiens_hsa052151.12574830
26RNA transport_Homo sapiens_hsa030131.12565195
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12137988
28B cell receptor signaling pathway_Homo sapiens_hsa046621.12082138
29VEGF signaling pathway_Homo sapiens_hsa043701.11464686
30Proteoglycans in cancer_Homo sapiens_hsa052051.11360868
31Viral carcinogenesis_Homo sapiens_hsa052031.11146834
32Pancreatic cancer_Homo sapiens_hsa052121.09620400
33Lysine degradation_Homo sapiens_hsa003101.09611001
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09580634
35Renal cell carcinoma_Homo sapiens_hsa052111.07365253
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06319250
37One carbon pool by folate_Homo sapiens_hsa006701.04888431
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04545093
39Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04298356
40mRNA surveillance pathway_Homo sapiens_hsa030151.04099691
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03509550
42Pentose phosphate pathway_Homo sapiens_hsa000301.03121015
43Hepatitis B_Homo sapiens_hsa051611.03080388
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99927785
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99892902
46Hippo signaling pathway_Homo sapiens_hsa043900.99600954
47Primary immunodeficiency_Homo sapiens_hsa053400.97920523
48Mismatch repair_Homo sapiens_hsa034300.97843236
49Cell cycle_Homo sapiens_hsa041100.97370597
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.96905055
51Osteoclast differentiation_Homo sapiens_hsa043800.96511488
52Measles_Homo sapiens_hsa051620.95979699
53Insulin signaling pathway_Homo sapiens_hsa049100.95904332
54Dorso-ventral axis formation_Homo sapiens_hsa043200.95727326
55Glioma_Homo sapiens_hsa052140.95419039
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.95364986
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94923757
58PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94496081
59N-Glycan biosynthesis_Homo sapiens_hsa005100.94364418
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93975122
61Base excision repair_Homo sapiens_hsa034100.93730821
62TGF-beta signaling pathway_Homo sapiens_hsa043500.93672700
63TNF signaling pathway_Homo sapiens_hsa046680.92240915
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91226000
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91094235
66Hematopoietic cell lineage_Homo sapiens_hsa046400.90891304
67AMPK signaling pathway_Homo sapiens_hsa041520.90663445
68Endometrial cancer_Homo sapiens_hsa052130.90378132
69Apoptosis_Homo sapiens_hsa042100.89912220
70Spliceosome_Homo sapiens_hsa030400.89598825
71Pathways in cancer_Homo sapiens_hsa052000.89354143
72Prolactin signaling pathway_Homo sapiens_hsa049170.87580185
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.87244680
74Nucleotide excision repair_Homo sapiens_hsa034200.86681482
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85955432
76Epstein-Barr virus infection_Homo sapiens_hsa051690.84426644
77MAPK signaling pathway_Homo sapiens_hsa040100.83016579
78Wnt signaling pathway_Homo sapiens_hsa043100.82683353
79Type I diabetes mellitus_Homo sapiens_hsa049400.82089315
80Shigellosis_Homo sapiens_hsa051310.81902331
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81880705
82Bladder cancer_Homo sapiens_hsa052190.81715677
83Rap1 signaling pathway_Homo sapiens_hsa040150.81450301
84Estrogen signaling pathway_Homo sapiens_hsa049150.81303277
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81087577
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80620097
87Leishmaniasis_Homo sapiens_hsa051400.80267104
88Non-homologous end-joining_Homo sapiens_hsa034500.78161321
89ErbB signaling pathway_Homo sapiens_hsa040120.78060581
90Thyroid cancer_Homo sapiens_hsa052160.77696940
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77504124
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.77323275
93Amoebiasis_Homo sapiens_hsa051460.76887255
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74820212
95Fructose and mannose metabolism_Homo sapiens_hsa000510.74757384
96Axon guidance_Homo sapiens_hsa043600.74739501
97mTOR signaling pathway_Homo sapiens_hsa041500.73699300
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72849591
99Platelet activation_Homo sapiens_hsa046110.72342243
100Tight junction_Homo sapiens_hsa045300.71583316
101Fatty acid biosynthesis_Homo sapiens_hsa000610.71479559
102Chemokine signaling pathway_Homo sapiens_hsa040620.70843422
103Galactose metabolism_Homo sapiens_hsa000520.70681146
104Herpes simplex infection_Homo sapiens_hsa051680.70616146
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70310403
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70087621
107Melanoma_Homo sapiens_hsa052180.69287158
108Protein digestion and absorption_Homo sapiens_hsa049740.69220376
109Non-small cell lung cancer_Homo sapiens_hsa052230.68739622
110Vibrio cholerae infection_Homo sapiens_hsa051100.68635659
111Allograft rejection_Homo sapiens_hsa053300.68344319
112p53 signaling pathway_Homo sapiens_hsa041150.68047409
113Basal cell carcinoma_Homo sapiens_hsa052170.67557513
114Ras signaling pathway_Homo sapiens_hsa040140.65780329
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.65296770
116Antigen processing and presentation_Homo sapiens_hsa046120.64795934
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64166737
118Selenocompound metabolism_Homo sapiens_hsa004500.64093446
119FoxO signaling pathway_Homo sapiens_hsa040680.63531444
120Insulin resistance_Homo sapiens_hsa049310.63079297
121Dilated cardiomyopathy_Homo sapiens_hsa054140.62999379
122Hepatitis C_Homo sapiens_hsa051600.62285789
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60969425
124Melanogenesis_Homo sapiens_hsa049160.60607350
125RNA degradation_Homo sapiens_hsa030180.60538873
126Ribosome_Homo sapiens_hsa030100.60247726
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59804719
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59735998
129Endocytosis_Homo sapiens_hsa041440.59561865
130Choline metabolism in cancer_Homo sapiens_hsa052310.58522433
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58483203
132GnRH signaling pathway_Homo sapiens_hsa049120.57427983
133Inositol phosphate metabolism_Homo sapiens_hsa005620.57293017
134Thyroid hormone synthesis_Homo sapiens_hsa049180.55623877
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54792078
136Carbon metabolism_Homo sapiens_hsa012000.53532246
137Glucagon signaling pathway_Homo sapiens_hsa049220.53508345
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52528929
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.51733121
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51139389
141Long-term potentiation_Homo sapiens_hsa047200.51121659
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.50968702

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