SLC7A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.86317413
2response to peptidoglycan (GO:0032494)5.64173401
3positive regulation of chemokine biosynthetic process (GO:0045080)5.44213143
4cell adhesion mediated by integrin (GO:0033627)5.39422622
5hydrogen peroxide biosynthetic process (GO:0050665)5.30062134
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.29351085
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.29351085
8modulation by symbiont of host immune response (GO:0052553)5.29351085
9positive regulation by symbiont of host defense response (GO:0052509)5.29351085
10modulation by symbiont of host defense response (GO:0052031)5.29351085
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.29351085
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.11677416
13superoxide anion generation (GO:0042554)4.94612702
14positive regulation of cellular amide metabolic process (GO:0034250)4.90711622
15positive regulation of heat generation (GO:0031652)4.87694326
16protein localization to endosome (GO:0036010)4.75221103
17regulation of fever generation (GO:0031620)4.73249840
18regulation of chemokine biosynthetic process (GO:0045073)4.72855388
19lipopolysaccharide-mediated signaling pathway (GO:0031663)4.67842733
20reactive oxygen species biosynthetic process (GO:1903409)4.66791592
21granulocyte activation (GO:0036230)4.62723073
22respiratory burst (GO:0045730)4.51961983
23positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.49836532
24positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.41529798
25cellular response to thyroid hormone stimulus (GO:0097067)4.36231708
26glycosphingolipid catabolic process (GO:0046479)4.35940404
27oligosaccharide catabolic process (GO:0009313)4.32304551
28neutrophil activation (GO:0042119)4.31308426
29macrophage activation involved in immune response (GO:0002281)4.14485018
30regulation of membrane protein ectodomain proteolysis (GO:0051043)4.09810216
31regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.07858107
32glycolipid catabolic process (GO:0019377)4.01474736
33positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.94391839
34production of molecular mediator involved in inflammatory response (GO:0002532)3.92433441
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.91412000
36immunoglobulin mediated immune response (GO:0016064)3.90687025
37T-helper 1 type immune response (GO:0042088)3.85160750
38positive regulation of interferon-alpha production (GO:0032727)3.79722100
39positive regulation of mast cell degranulation (GO:0043306)3.78903221
40positive regulation of mast cell activation involved in immune response (GO:0033008)3.78903221
41negative regulation of interleukin-17 production (GO:0032700)3.78613060
42regulation of heat generation (GO:0031650)3.77546653
43wound healing, spreading of epidermal cells (GO:0035313)3.75458324
44regulation of mononuclear cell migration (GO:0071675)3.68917462
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.68626555
46response to host immune response (GO:0052572)3.68626555
47regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.68438792
48regulation of activation of Janus kinase activity (GO:0010533)3.65026339
49retina vasculature morphogenesis in camera-type eye (GO:0061299)3.62823197
50regulation of lymphocyte chemotaxis (GO:1901623)3.62571812
51regulation of interferon-alpha production (GO:0032647)3.61617378
52leukocyte aggregation (GO:0070486)3.58932265
53regulation of macrophage chemotaxis (GO:0010758)3.57345780
54detection of molecule of bacterial origin (GO:0032490)3.57023157
55regulation of vitamin D biosynthetic process (GO:0060556)3.55272739
56cellular response to arsenic-containing substance (GO:0071243)3.53961824
57eosinophil chemotaxis (GO:0048245)3.52634401
58membrane lipid catabolic process (GO:0046466)3.52104195
59regulation of early endosome to late endosome transport (GO:2000641)3.51071892
60response to lipoprotein particle (GO:0055094)3.50813555
61defense response to protozoan (GO:0042832)3.50781805
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50101594
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.49825616
64negative regulation of lipid storage (GO:0010888)3.47212639
65ceramide catabolic process (GO:0046514)3.45468945
66regulation of vascular endothelial growth factor production (GO:0010574)3.42756631
67substrate-dependent cell migration (GO:0006929)3.42299595
68myeloid cell activation involved in immune response (GO:0002275)3.39877769
69positive regulation of NF-kappaB import into nucleus (GO:0042346)3.36390790
70microglial cell activation (GO:0001774)3.35393818
71response to muramyl dipeptide (GO:0032495)3.31166978
72response to thyroid hormone (GO:0097066)3.30906436
73positive regulation of mast cell activation (GO:0033005)3.30033691
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.29645794
75positive regulation of extracellular matrix organization (GO:1903055)3.28445188
76eosinophil migration (GO:0072677)3.28217144
77macrophage activation (GO:0042116)3.24336078
78response to host (GO:0075136)3.23647632
79response to host defenses (GO:0052200)3.23647632
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23647632
81positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.22702032
82regulation of interleukin-17 production (GO:0032660)3.22573813
83regulation of chronic inflammatory response (GO:0002676)3.20652546
84positive regulation of type 2 immune response (GO:0002830)3.20103881
85dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.19520619
86regulation of T-helper 1 cell differentiation (GO:0045625)3.19322225
87osteoclast differentiation (GO:0030316)3.18855813
88positive regulation of nitric oxide biosynthetic process (GO:0045429)3.17196387
89regulation of cholesterol storage (GO:0010885)3.17182082
90positive regulation of monocyte chemotaxis (GO:0090026)3.16118314
91apoptotic cell clearance (GO:0043277)3.15905082
92regulation of cytokine secretion involved in immune response (GO:0002739)3.15783255
93positive regulation of chemokine production (GO:0032722)3.15092982
94neutrophil mediated immunity (GO:0002446)3.13702639
95monocyte chemotaxis (GO:0002548)3.13546272
96cellular response to zinc ion (GO:0071294)3.13393268
97regulation of vitamin metabolic process (GO:0030656)3.13253608
98iron ion import (GO:0097286)3.12991583
99regulation of interferon-beta biosynthetic process (GO:0045357)3.11550331
100natural killer cell mediated immunity (GO:0002228)3.10963339
101natural killer cell mediated cytotoxicity (GO:0042267)3.10963339
102positive regulation of interleukin-12 production (GO:0032735)3.09356137
103regulation of heterotypic cell-cell adhesion (GO:0034114)3.08302631
104regulation of mast cell degranulation (GO:0043304)3.07449681
105negative regulation of interleukin-12 production (GO:0032695)3.07097992
106positive regulation of interleukin-17 production (GO:0032740)3.06259732
107positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.04646749
108positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.03044733
109negative regulation of nitric oxide biosynthetic process (GO:0045019)3.02926381
110positive regulation vascular endothelial growth factor production (GO:0010575)3.02588482
111regulation of immunoglobulin secretion (GO:0051023)3.00227448
112phagosome maturation (GO:0090382)2.99069011
113skin morphogenesis (GO:0043589)2.97485855
114positive regulation of acute inflammatory response (GO:0002675)2.97260711
115regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96939682
116interferon-gamma-mediated signaling pathway (GO:0060333)2.96887409
117negative regulation of myeloid cell apoptotic process (GO:0033033)2.96458547
118positive regulation of interleukin-6 production (GO:0032755)2.96130370
119response to protozoan (GO:0001562)2.95824487
120positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.92924064
121positive regulation of endothelial cell apoptotic process (GO:2000353)2.92022237
122positive regulation of interleukin-10 production (GO:0032733)2.91502550
123positive regulation of leukocyte degranulation (GO:0043302)2.88843429
124leukocyte mediated cytotoxicity (GO:0001909)2.88575483
125sphingosine metabolic process (GO:0006670)2.88243641
126regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.88120058
127positive regulation of leukocyte migration (GO:0002687)2.87308425
128regulation of mast cell activation involved in immune response (GO:0033006)2.85814144
129positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.85725201
130positive regulation of leukocyte chemotaxis (GO:0002690)2.84595805
131regulation of podosome assembly (GO:0071801)2.84236273
132neutrophil chemotaxis (GO:0030593)2.84088464
133superoxide metabolic process (GO:0006801)2.84077473
134positive regulation of tumor necrosis factor production (GO:0032760)2.83982731
135endodermal cell differentiation (GO:0035987)2.83623111
136positive regulation of interferon-beta production (GO:0032728)2.83286092
137cellular response to ethanol (GO:0071361)2.83198833
138glial cell migration (GO:0008347)2.82423829
139decidualization (GO:0046697)2.80165266
140sphingolipid catabolic process (GO:0030149)2.79719766
141cellular response to lipopolysaccharide (GO:0071222)2.79120701
142epithelial cell-cell adhesion (GO:0090136)2.77391630
143cellular extravasation (GO:0045123)2.76777239
144fat-soluble vitamin biosynthetic process (GO:0042362)2.71802226
145mRNA transcription (GO:0009299)2.71277889
146regulation of nitric oxide biosynthetic process (GO:0045428)2.70737026
147regulation of integrin activation (GO:0033623)2.69538596
148response to arsenic-containing substance (GO:0046685)2.68255017
149regulation of monocyte chemotaxis (GO:0090025)2.66504948
150L-alpha-amino acid transmembrane transport (GO:1902475)2.65118006
151hypotonic response (GO:0006971)2.64206792
152regulation of NF-kappaB import into nucleus (GO:0042345)2.64105299
153cellular response to molecule of bacterial origin (GO:0071219)2.63600556
154barbed-end actin filament capping (GO:0051016)2.63497064
155granulocyte chemotaxis (GO:0071621)2.58000078
156regulation of prostaglandin secretion (GO:0032306)2.57563888
157wound healing, spreading of cells (GO:0044319)2.56536899
158hyaluronan catabolic process (GO:0030214)2.54198925
159negative regulation of focal adhesion assembly (GO:0051895)2.53655425
160negative regulation of cell junction assembly (GO:1901889)2.53655425
161negative regulation of adherens junction organization (GO:1903392)2.53655425
162negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.49529998
163response to laminar fluid shear stress (GO:0034616)2.49222712
164negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.49120616
165nuclear pore complex assembly (GO:0051292)2.48287935
166negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.46249970
167pore complex assembly (GO:0046931)2.46033778
168granulocyte migration (GO:0097530)2.44251162
169mammary gland epithelial cell proliferation (GO:0033598)2.43876441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.45823810
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.39383265
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.96749274
4* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.92768273
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.81202288
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.68591752
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.54469914
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.53437820
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.37910842
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.32098013
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11202237
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05072164
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.70221490
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56698881
15SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.48042367
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43528001
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.37972344
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.37972344
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31573825
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18522937
21CLOCK_20551151_ChIP-Seq_293T_Human2.16278793
22AR_21909140_ChIP-Seq_LNCAP_Human2.09177192
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01324461
24TFEB_21752829_ChIP-Seq_HELA_Human2.00293421
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.97666244
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.95443116
27ZNF263_19887448_ChIP-Seq_K562_Human1.93331584
28VDR_24787735_ChIP-Seq_THP-1_Human1.91964891
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91065596
30BRD4_25478319_ChIP-Seq_HGPS_Human1.87625439
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.80065433
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79422074
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.76726727
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64851399
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63179141
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62508939
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61498883
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60822991
39UBF1/2_26484160_Chip-Seq_HMECs_Human1.59305236
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58901413
41* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58862765
42* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57376548
43* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57376548
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56589281
45* ATF3_27146783_Chip-Seq_COLON_Human1.56347542
46EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.55697229
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54018170
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51612339
49E2F7_22180533_ChIP-Seq_HELA_Human1.45520091
50* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.45166670
51GATA1_22025678_ChIP-Seq_K562_Human1.44679177
52RUNX_20019798_ChIP-Seq_JUKART_Human1.42042439
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41315737
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40723672
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39431680
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.37717331
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36426814
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.30662488
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30189536
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30086485
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29164116
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28770397
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28726162
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28686047
65SPI1_23547873_ChIP-Seq_NB4_Human1.27358189
66PU_27001747_Chip-Seq_BMDM_Mouse1.26135068
67* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25070253
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23555398
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22334061
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22251470
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.20129759
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19806267
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18219343
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17435686
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.15940765
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15526881
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13519247
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12024996
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10936354
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10707649
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10205317
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.08008291
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07918365
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07582276
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.06739071
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03799003
87* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03610632
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03603450
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03577165
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02691770
91VDR_24763502_ChIP-Seq_THP-1_Human1.00206673
92TP53_18474530_ChIP-ChIP_U2OS_Human1.00068311
93TRIM28_21343339_ChIP-Seq_HEK293_Human0.99785903
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98689670
95* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98182453
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98154510
97SPI1_23127762_ChIP-Seq_K562_Human0.97924471
98* CJUN_26792858_Chip-Seq_BT549_Human0.96770214
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95142265
100* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94654848
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93891092
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92285427
103MYB_26560356_Chip-Seq_TH2_Human0.91543780
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91135939
105SOX2_20726797_ChIP-Seq_SW620_Human0.90874701
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90666881
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90480748
108ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90317055
109GBX2_23144817_ChIP-Seq_PC3_Human0.89714321
110RXR_22108803_ChIP-Seq_LS180_Human0.89691341
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89242307
112GATA3_26560356_Chip-Seq_TH2_Human0.89132699
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89018036
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87850709
115TP53_22127205_ChIP-Seq_IMR90_Human0.87220405
116NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86979809
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.86596935
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86063124
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85526705
120* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85183625
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85037126
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84997415
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83964957
124MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83290583
125PU1_27457419_Chip-Seq_LIVER_Mouse0.83255356
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82024711
127* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81194418
128ELK1_19687146_ChIP-ChIP_HELA_Human0.80977498
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.80718391
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80610008
131TP53_16413492_ChIP-PET_HCT116_Human0.80339065
132MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78619846
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.78172223
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77793408
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.77697878
136GATA3_27048872_Chip-Seq_THYMUS_Human0.77452236
137* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.76468978
138* E2F1_18555785_Chip-Seq_ESCs_Mouse0.76451241
139* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76132952
140PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.76013289
141TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.75940437
142* STAT3_18555785_Chip-Seq_ESCs_Mouse0.75919006
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75823646
144* P53_22387025_ChIP-Seq_ESCs_Mouse0.74342501
145SCL_19346495_ChIP-Seq_HPC-7_Human0.73445622
146* NMYC_18555785_Chip-Seq_ESCs_Mouse0.73341428
147SOX2_18555785_Chip-Seq_ESCs_Mouse0.72871988
148* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72332762
149VDR_22108803_ChIP-Seq_LS180_Human0.72187370
150SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.72123620
151* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.71822412
152* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.71804482
153* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.71037373
154SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70802693
155PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70088156
156* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.69836875
157EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.69230701
158RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.68181411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.68186669
2MP0001835_abnormal_antigen_presentation4.39434272
3MP0002148_abnormal_hypersensitivity_rea4.16442675
4MP0003436_decreased_susceptibility_to3.97085456
5MP0002877_abnormal_melanocyte_morpholog3.83188990
6MP0009840_abnormal_foam_cell3.82613625
7MP0003724_increased_susceptibility_to3.68360334
8MP0006082_CNS_inflammation3.57332998
9* MP0002419_abnormal_innate_immunity3.51283196
10MP0005000_abnormal_immune_tolerance3.40795255
11MP0003705_abnormal_hypodermis_morpholog3.17319867
12MP0005025_abnormal_response_to3.16810289
13MP0003303_peritoneal_inflammation3.09328958
14MP0009764_decreased_sensitivity_to2.63146585
15MP0010352_gastrointestinal_tract_polyps2.62083492
16MP0001790_abnormal_immune_system2.57930225
17MP0005387_immune_system_phenotype2.57930225
18* MP0002452_abnormal_antigen_presenting2.55524047
19MP0004233_abnormal_muscle_weight2.54224300
20MP0005671_abnormal_response_to2.53358863
21MP0002723_abnormal_immune_serum2.45913245
22MP0004510_myositis2.45734864
23MP0000685_abnormal_immune_system2.44124080
24MP0006054_spinal_hemorrhage2.43947549
25MP0008438_abnormal_cutaneous_collagen2.39187687
26MP0005167_abnormal_blood-brain_barrier2.30679847
27MP0003806_abnormal_nucleotide_metabolis2.25201292
28MP0002006_tumorigenesis2.22468034
29MP0001800_abnormal_humoral_immune2.19787064
30MP0003950_abnormal_plasma_membrane2.16377860
31MP0003075_altered_response_to2.14951586
32MP0001533_abnormal_skeleton_physiology2.12284395
33MP0003300_gastrointestinal_ulcer2.09808934
34* MP0001819_abnormal_immune_cell2.07102831
35* MP0002420_abnormal_adaptive_immunity2.01848552
36MP0001853_heart_inflammation2.01526376
37MP0005058_abnormal_lysosome_morphology1.99986166
38MP0004947_skin_inflammation1.98080535
39MP0003566_abnormal_cell_adhesion1.95135967
40MP0001845_abnormal_inflammatory_respons1.94279079
41MP0003195_calcinosis1.90802107
42MP0003448_altered_tumor_morphology1.85800473
43MP0003656_abnormal_erythrocyte_physiolo1.84825336
44MP0002405_respiratory_system_inflammati1.80622483
45MP0002139_abnormal_hepatobiliary_system1.79211982
46MP0002998_abnormal_bone_remodeling1.76101689
47MP0003941_abnormal_skin_development1.70380465
48MP0008469_abnormal_protein_level1.66021272
49MP0000343_altered_response_to1.65819747
50* MP0005464_abnormal_platelet_physiology1.63425056
51MP0010234_abnormal_vibrissa_follicle1.57554517
52MP0005310_abnormal_salivary_gland1.55798399
53MP0009278_abnormal_bone_marrow1.54807932
54MP0002254_reproductive_system_inflammat1.52750108
55MP0002277_abnormal_respiratory_mucosa1.52651975
56MP0003186_abnormal_redox_activity1.52147459
57MP0005166_decreased_susceptibility_to1.52064776
58MP0000858_altered_metastatic_potential1.50639498
59MP0003828_pulmonary_edema1.48375998
60MP0004272_abnormal_basement_membrane1.47990414
61MP0010155_abnormal_intestine_physiology1.45795394
62MP0005164_abnormal_response_to1.45665163
63MP0005023_abnormal_wound_healing1.45354281
64MP0010678_abnormal_skin_adnexa1.39041399
65MP0000569_abnormal_digit_pigmentation1.36408760
66MP0002332_abnormal_exercise_endurance1.35772315
67MP0003690_abnormal_glial_cell1.33901599
68MP0010307_abnormal_tumor_latency1.33499526
69MP0000716_abnormal_immune_system1.31385521
70MP0009333_abnormal_splenocyte_physiolog1.28161114
71MP0008260_abnormal_autophagy1.27667799
72MP0001849_ear_inflammation1.27627134
73MP0005171_absent_coat_pigmentation1.26122321
74MP0003136_yellow_coat_color1.25275182
75MP0004858_abnormal_nervous_system1.21242756
76MP0004782_abnormal_surfactant_physiolog1.20581510
77MP0000383_abnormal_hair_follicle1.16429031
78MP0002896_abnormal_bone_mineralization1.15000791
79MP0003646_muscle_fatigue1.13784385
80MP0005390_skeleton_phenotype1.11653240
81MP0003172_abnormal_lysosome_physiology1.11047895
82MP0005197_abnormal_uvea_morphology1.09321590
83MP0001915_intracranial_hemorrhage1.08942898
84MP0004185_abnormal_adipocyte_glucose1.07140235
85MP0003329_amyloid_beta_deposits1.05199143
86MP0008007_abnormal_cellular_replicative1.05006303
87MP0003279_aneurysm1.04366269
88MP0002398_abnormal_bone_marrow1.02681449
89MP0001501_abnormal_sleep_pattern1.00374811
90MP0001542_abnormal_bone_strength0.98278152
91MP0001545_abnormal_hematopoietic_system0.96757296
92MP0005397_hematopoietic_system_phenotyp0.96757296
93MP0009763_increased_sensitivity_to0.96332250
94MP0005451_abnormal_body_composition0.96082873
95MP0003183_abnormal_peptide_metabolism0.95231107
96MP0005595_abnormal_vascular_smooth0.95057354
97MP0000604_amyloidosis0.93403806
98MP0002429_abnormal_blood_cell0.92669555
99MP0001243_abnormal_dermal_layer0.88952205
100MP0004808_abnormal_hematopoietic_stem0.86717601
101MP0002933_joint_inflammation0.85801376
102MP0003453_abnormal_keratinocyte_physiol0.83195854
103* MP0000371_diluted_coat_color0.82812621
104MP0001216_abnormal_epidermal_layer0.81117335
105MP0000920_abnormal_myelination0.78477190
106MP0002060_abnormal_skin_morphology0.77342995
107MP0000372_irregular_coat_pigmentation0.77136573
108MP0001851_eye_inflammation0.76743137
109MP0010386_abnormal_urinary_bladder0.75440157
110MP0000689_abnormal_spleen_morphology0.74590459
111MP0003221_abnormal_cardiomyocyte_apopto0.74008274
112MP0009765_abnormal_xenobiotic_induced0.73615533
113MP0000750_abnormal_muscle_regeneration0.72051284
114MP0003634_abnormal_glial_cell0.71938906
115MP0000249_abnormal_blood_vessel0.71466305
116MP0002295_abnormal_pulmonary_circulatio0.71065669
117MP0003191_abnormal_cellular_cholesterol0.70510548
118MP0005076_abnormal_cell_differentiation0.69854605
119MP0005621_abnormal_cell_physiology0.68833912
120MP0002722_abnormal_immune_system0.68766241
121MP0001191_abnormal_skin_condition0.68632120
122MP0005623_abnormal_meninges_morphology0.68403936
123MP0005647_abnormal_sex_gland0.67332551
124MP0005535_abnormal_body_temperature0.66321078
125MP0004883_abnormal_blood_vessel0.65082854
126MP0003795_abnormal_bone_structure0.64803128
127MP0000767_abnormal_smooth_muscle0.64459985
128MP0002166_altered_tumor_susceptibility0.63686213
129MP0005174_abnormal_tail_pigmentation0.62873909
130MP0003091_abnormal_cell_migration0.56854502
131MP0003045_fibrosis0.55348108
132MP0005257_abnormal_intraocular_pressure0.55196654
133MP0002136_abnormal_kidney_physiology0.54564742
134MP0008004_abnormal_stomach_pH0.54202987
135MP0002638_abnormal_pupillary_reflex0.49830539
136MP0002693_abnormal_pancreas_physiology0.49126148
137MP0002163_abnormal_gland_morphology0.48592272
138MP0005165_increased_susceptibility_to0.47302941
139MP0002138_abnormal_hepatobiliary_system0.46970073
140MP0001346_abnormal_lacrimal_gland0.46606412
141MP0000015_abnormal_ear_pigmentation0.46242152
142MP0002090_abnormal_vision0.44752485
143MP0002168_other_aberrant_phenotype0.44617011

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)8.37081035
2Recurrent abscess formation (HP:0002722)8.33968455
3Recurrent bacterial skin infections (HP:0005406)7.83378133
4Recurrent gram-negative bacterial infections (HP:0005420)7.48198989
5Mediastinal lymphadenopathy (HP:0100721)6.49015299
6Abnormality of macrophages (HP:0004311)5.60196319
7Stomatitis (HP:0010280)5.37080502
8Gingivitis (HP:0000230)4.99950475
9Increased IgM level (HP:0003496)4.79775952
10Recurrent skin infections (HP:0001581)4.63188927
11Neurofibrillary tangles (HP:0002185)4.45057236
12Chronic obstructive pulmonary disease (HP:0006510)4.44066816
13Obstructive lung disease (HP:0006536)4.44066816
14Optic neuritis (HP:0100653)4.41590157
15Retrobulbar optic neuritis (HP:0100654)4.41590157
16Autoimmune thrombocytopenia (HP:0001973)4.40532121
17Elevated erythrocyte sedimentation rate (HP:0003565)4.23555456
18Orchitis (HP:0100796)4.16680512
19Recurrent fungal infections (HP:0002841)3.87907150
20Vasculitis (HP:0002633)3.73409621
21Myositis (HP:0100614)3.71533651
22Nuclear cataract (HP:0100018)3.55363598
23Loss of speech (HP:0002371)3.53608448
24Tetraparesis (HP:0002273)3.48466879
25Thick nail (HP:0001805)3.41651893
26Premature rupture of membranes (HP:0001788)3.39533148
27Cerebral inclusion bodies (HP:0100314)3.36462477
28Basal ganglia calcification (HP:0002135)3.30183897
29Prostate neoplasm (HP:0100787)3.29566577
30Urticaria (HP:0001025)3.22543573
31Pulmonary infiltrates (HP:0002113)3.13632042
32Recurrent viral infections (HP:0004429)3.13380389
33Periodontitis (HP:0000704)3.12436426
34Cortical dysplasia (HP:0002539)3.11862447
35Vacuolated lymphocytes (HP:0001922)3.07448298
36Recurrent pneumonia (HP:0006532)3.06283726
37Upper limb muscle weakness (HP:0003484)3.00198751
38Gastrointestinal infarctions (HP:0005244)2.99854932
39Cellulitis (HP:0100658)2.99117172
40Recurrent cutaneous fungal infections (HP:0011370)2.91656986
41Chronic mucocutaneous candidiasis (HP:0002728)2.91656986
42Axonal loss (HP:0003447)2.91138334
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.90196655
44Poor head control (HP:0002421)2.84762779
45Interstitial pulmonary disease (HP:0006530)2.79547929
46Meningitis (HP:0001287)2.75541137
47Increased cerebral lipofuscin (HP:0011813)2.75269788
48Multiple enchondromatosis (HP:0005701)2.74066240
49Systemic lupus erythematosus (HP:0002725)2.71690087
50Hypergammaglobulinemia (HP:0010702)2.62904236
51Skin nodule (HP:0200036)2.62205282
52Apathy (HP:0000741)2.61852679
53Premature loss of primary teeth (HP:0006323)2.61708211
54Urinary glycosaminoglycan excretion (HP:0003541)2.61280802
55Mucopolysacchariduria (HP:0008155)2.61280802
56Metaphyseal irregularity (HP:0003025)2.58221439
57Mutism (HP:0002300)2.56170451
58Abnormality of polysaccharide metabolism (HP:0011012)2.54983878
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54983878
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54983878
61Abnormality of the vasculature of the conjunctiva (HP:0008054)2.54788162
62Pustule (HP:0200039)2.53891799
63Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.53791761
64Recurrent lower respiratory tract infections (HP:0002783)2.53307697
65Diminished motivation (HP:0000745)2.52645011
66Keratoconjunctivitis sicca (HP:0001097)2.51371161
67Short nail (HP:0001799)2.49000889
68Atrophic scars (HP:0001075)2.48829727
69Osteomyelitis (HP:0002754)2.48005593
70Leukocytosis (HP:0001974)2.46625968
71Upper motor neuron abnormality (HP:0002127)2.45038683
72Hemoptysis (HP:0002105)2.43190307
73Subacute progressive viral hepatitis (HP:0006572)2.42024793
74Spastic diplegia (HP:0001264)2.41484372
75Abnormality of liposaccharide metabolism (HP:0010968)2.39062999
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.39062999
77Abnormality of glycolipid metabolism (HP:0010969)2.39062999
78Spondylolisthesis (HP:0003302)2.37985450
79Myocardial infarction (HP:0001658)2.37842432
80Glomerulonephritis (HP:0000099)2.36438010
81Nephritis (HP:0000123)2.34884951
82Arterial thrombosis (HP:0004420)2.32378009
83Keratoconjunctivitis (HP:0001096)2.31994047
84Disinhibition (HP:0000734)2.31498634
85Gingival bleeding (HP:0000225)2.29372722
86Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.23325158
87Abnormality of the pericardium (HP:0001697)2.22637749
88Esophageal varix (HP:0002040)2.21938861
89Autoimmune hemolytic anemia (HP:0001890)2.21297471
90Sepsis (HP:0100806)2.19102414
91Epidermoid cyst (HP:0200040)2.18950231
92Porencephaly (HP:0002132)2.17354567
93Fused cervical vertebrae (HP:0002949)2.16779605
94Inappropriate behavior (HP:0000719)2.13267720
95Natal tooth (HP:0000695)2.09527851
96Abnormality of T cell number (HP:0011839)2.09420609
97Protrusio acetabuli (HP:0003179)2.07488515
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04743612
99Multiple lipomas (HP:0001012)2.04432886
100Joint hemorrhage (HP:0005261)2.03158593
101Bone pain (HP:0002653)2.03116550
102Parakeratosis (HP:0001036)2.03055709
103Abnormality of the periventricular white matter (HP:0002518)1.98245014
104Global brain atrophy (HP:0002283)1.98154168
105Cervical subluxation (HP:0003308)1.98047488
106Nausea (HP:0002018)1.97319222
107Anorexia (HP:0002039)1.94474222
108Joint swelling (HP:0001386)1.92963821
109Thin bony cortex (HP:0002753)1.92103384
110Arthralgia (HP:0002829)1.91674163
111Abnormality of the pleura (HP:0002103)1.90391646
112Hematochezia (HP:0002573)1.89029129
113Aplasia cutis congenita (HP:0001057)1.88173883
114Purpura (HP:0000979)1.86433505
115Neuronal loss in central nervous system (HP:0002529)1.85470451
116Gangrene (HP:0100758)1.84655126
117Gastrointestinal stroma tumor (HP:0100723)1.82598365
118Abnormality of oral frenula (HP:0000190)1.82409508
119Xanthomatosis (HP:0000991)1.79060368
120Abnormality of the nasal septum (HP:0000419)1.78542618
121Femoral bowing (HP:0002980)1.76864558
122Peritonitis (HP:0002586)1.76099741
123Ankyloglossia (HP:0010296)1.75219480
124Cheilitis (HP:0100825)1.75130386
125Petechiae (HP:0000967)1.74873645
126Absent frontal sinuses (HP:0002688)1.74750651
127Conjunctival telangiectasia (HP:0000524)1.73630488
128Dysostosis multiplex (HP:0000943)1.73253081
129Tibial bowing (HP:0002982)1.72286602
130Progressive visual loss (HP:0000529)1.72220617
131Prolonged neonatal jaundice (HP:0006579)1.70227093
132Buphthalmos (HP:0000557)1.69832883
133Hepatosplenomegaly (HP:0001433)1.69763832
134Pathologic fracture (HP:0002756)1.69498209
135T lymphocytopenia (HP:0005403)1.69226548
136Vertebral compression fractures (HP:0002953)1.68796522
137Eosinophilia (HP:0001880)1.68574759
138Abnormality of the prostate (HP:0008775)1.68111070
139Syringomyelia (HP:0003396)1.66916358
140Spinal cord lesions (HP:0100561)1.66916358
141Abnormal trabecular bone morphology (HP:0100671)1.66747332
142Arterial tortuosity (HP:0005116)1.66573467
143Hyperacusis (HP:0010780)1.66237721
144Termporal pattern (HP:0011008)1.66104568
145Insidious onset (HP:0003587)1.66104568
146Zonular cataract (HP:0010920)1.65770218
147Thyroiditis (HP:0100646)1.64993084
148Congenital sensorineural hearing impairment (HP:0008527)1.64771259
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.64652192
150Osteolytic defects of the hand bones (HP:0009699)1.64652192
151Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64564419
152Ankle contracture (HP:0006466)1.64365044
153Albinism (HP:0001022)1.64264109
154Dysphonia (HP:0001618)1.63552169
155Agnosia (HP:0010524)1.63481739
156Protuberant abdomen (HP:0001538)1.63286426
157Increased serum ferritin (HP:0003281)1.62214505
158Ovoid vertebral bodies (HP:0003300)1.62033197
159Skin ulcer (HP:0200042)1.61957749
160Vascular tortuosity (HP:0004948)1.61205846
161Pseudobulbar signs (HP:0002200)1.60464423
162Anhidrosis (HP:0000970)1.60080503
163Thoracic kyphosis (HP:0002942)1.59536635
164Coarse hair (HP:0002208)1.58325732
165Insomnia (HP:0100785)1.58319193
166Congenital glaucoma (HP:0001087)1.57440757
167Fragile skin (HP:0001030)1.55880120
168Distal upper limb amyotrophy (HP:0007149)1.55427521
169Upper limb amyotrophy (HP:0009129)1.55427521
170Dementia (HP:0000726)1.54872144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.65853179
2PBK5.22353394
3MAP3K145.08039933
4DDR23.54607610
5BLK3.53800255
6IRAK33.44775581
7TBK13.22455122
8IRAK42.92764241
9IKBKB2.56145875
10TXK2.54583989
11IKBKE2.38317063
12TTN2.31415524
13ACVR1B2.26295259
14JAK32.24890319
15PDGFRA2.23341637
16TYK22.11862375
17STK242.09744448
18LATS22.00339867
19BMPR21.94338954
20TGFBR21.92422669
21PDK21.86447745
22MAP3K131.73168949
23MST1R1.68794273
24JAK11.65826692
25YES11.58898440
26EIF2AK31.57394336
27CHUK1.55517401
28PAK41.48664424
29TAOK21.40797021
30BMX1.36024908
31MST41.34896576
32CSK1.33972859
33FGR1.29549725
34PIM21.27681339
35SCYL21.27497799
36STK38L1.25762546
37ERBB41.22435388
38MARK31.21873818
39ABL21.17806269
40EIF2AK21.14096340
41MAP4K11.11771698
42LYN1.11735402
43KIT1.05063050
44ICK1.03224107
45SYK1.02929668
46CDC42BPA0.99048268
47HCK0.98112066
48MAP3K90.90697878
49TGFBR10.88510315
50KSR10.87854059
51RPS6KA40.87344725
52LCK0.87136004
53ERBB30.86924963
54SIK30.85991179
55PRKCD0.85488440
56CDK60.84321922
57LIMK10.84167679
58MATK0.82592290
59JAK20.81229268
60PAK20.81047685
61STK40.80881730
62IRAK20.79370988
63TYRO30.79066416
64CLK10.78256345
65MAP3K80.77931879
66PIM10.76834893
67MUSK0.75839502
68TIE10.75397616
69MAP3K30.75304761
70TTK0.74878273
71NTRK10.73535203
72IRAK10.73404087
73BMPR1B0.73144712
74NEK10.72993261
75PTK20.72418420
76MAP3K120.70036673
77ABL10.68566257
78MAP3K50.67752825
79GRK70.66253067
80LATS10.65720052
81ZAP700.64411454
82ADRBK20.62777071
83NEK90.60929809
84CAMKK20.60598646
85BTK0.60237923
86TEC0.57541946
87TRPM70.57326412
88EPHB10.56870519
89EGFR0.55447655
90ERN10.55358620
91DAPK20.54605106
92NLK0.54360770
93NME20.53557203
94PRKCQ0.52904190
95FGFR30.51945167
96ALK0.50712114
97EIF2AK10.49999741
98PLK20.49638203
99ADRBK10.49218413
100RPS6KC10.48830975
101RPS6KL10.48830975
102TAF10.47197515
103CAMK1G0.47175845
104RPS6KA20.47056953
105BRSK20.46935226
106MKNK10.46554388
107TAOK30.46293884
108PRKCE0.45930865
109PKN10.44230707
110TNIK0.42541962
111STK30.41939518
112EPHA30.40412662
113FES0.40324142
114PRKG20.39087588
115PDGFRB0.38526023
116FYN0.38207655
117CSF1R0.37009667
118GSK3A0.35387233
119SIK10.35012990
120MTOR0.33900525
121SIK20.33358860
122ARAF0.33221664
123CAMK1D0.32769608
124MAP3K10.32516082
125TSSK60.32294332
126FER0.32038698
127PDPK10.32032870
128BCR0.31232697
129EPHA20.31121937
130MET0.30673552
131MKNK20.30213906
132EPHB20.30123723
133KSR20.29623676
134IGF1R0.29095059
135NEK60.28413315
136PDK10.27044756
137MAP3K110.26911704
138INSR0.26706716
139STK100.26080617
140PRKCZ0.22952903
141MOS0.22308725
142RIPK10.22301823
143DAPK30.22168528
144PIK3CG0.18852792
145SGK10.18258956
146PRPF4B0.16982160
147SRC0.15155202
148RPS6KA60.13908713
149MELK0.13900496

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.34034663
2Leishmaniasis_Homo sapiens_hsa051403.37654245
3Allograft rejection_Homo sapiens_hsa053303.11783448
4Legionellosis_Homo sapiens_hsa051342.99191531
5Type I diabetes mellitus_Homo sapiens_hsa049402.98628201
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.78405908
7Malaria_Homo sapiens_hsa051442.77562891
8Staphylococcus aureus infection_Homo sapiens_hsa051502.75901101
9Rheumatoid arthritis_Homo sapiens_hsa053232.71266644
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.67613474
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.61904057
12African trypanosomiasis_Homo sapiens_hsa051432.59819363
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56595504
14Asthma_Homo sapiens_hsa053102.44567277
15Pertussis_Homo sapiens_hsa051332.29369890
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29271597
17Bladder cancer_Homo sapiens_hsa052192.26029332
18Tuberculosis_Homo sapiens_hsa051522.22674863
19TNF signaling pathway_Homo sapiens_hsa046682.12333175
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.07295950
21Osteoclast differentiation_Homo sapiens_hsa043802.06012740
22Salmonella infection_Homo sapiens_hsa051321.96330768
23Measles_Homo sapiens_hsa051621.82181033
24Phagosome_Homo sapiens_hsa041451.69313600
25Hematopoietic cell lineage_Homo sapiens_hsa046401.67017062
26Influenza A_Homo sapiens_hsa051641.62335320
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57722050
28Vitamin B6 metabolism_Homo sapiens_hsa007501.49010486
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.45688394
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41190602
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41172228
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37474458
33Chemokine signaling pathway_Homo sapiens_hsa040621.30468786
34Autoimmune thyroid disease_Homo sapiens_hsa053201.29326963
35Herpes simplex infection_Homo sapiens_hsa051681.26454107
36Selenocompound metabolism_Homo sapiens_hsa004501.25213437
37Toxoplasmosis_Homo sapiens_hsa051451.23976563
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23250622
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20635611
40Lysosome_Homo sapiens_hsa041421.18967965
41Amoebiasis_Homo sapiens_hsa051461.17791057
42Sulfur metabolism_Homo sapiens_hsa009201.10896866
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.09023589
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08459177
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08339245
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07621494
47Apoptosis_Homo sapiens_hsa042101.00387323
48MicroRNAs in cancer_Homo sapiens_hsa052060.97789093
49B cell receptor signaling pathway_Homo sapiens_hsa046620.95376733
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89879437
51Prion diseases_Homo sapiens_hsa050200.89605621
52Collecting duct acid secretion_Homo sapiens_hsa049660.88516693
53Hepatitis B_Homo sapiens_hsa051610.83124105
54Galactose metabolism_Homo sapiens_hsa000520.82466135
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81578967
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80966791
57Shigellosis_Homo sapiens_hsa051310.80918576
58Hepatitis C_Homo sapiens_hsa051600.75126030
59Glutathione metabolism_Homo sapiens_hsa004800.74695969
60Viral myocarditis_Homo sapiens_hsa054160.73500175
61Pentose phosphate pathway_Homo sapiens_hsa000300.71272310
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.70995259
63Mineral absorption_Homo sapiens_hsa049780.69991593
64ECM-receptor interaction_Homo sapiens_hsa045120.67497896
65Focal adhesion_Homo sapiens_hsa045100.66314127
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64946336
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.63912871
68Renal cell carcinoma_Homo sapiens_hsa052110.63521264
69PPAR signaling pathway_Homo sapiens_hsa033200.61052630
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60358076
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60348376
72Antigen processing and presentation_Homo sapiens_hsa046120.58028723
73Viral carcinogenesis_Homo sapiens_hsa052030.57818776
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54314263
75T cell receptor signaling pathway_Homo sapiens_hsa046600.54007845
76Steroid biosynthesis_Homo sapiens_hsa001000.53933186
77Primary immunodeficiency_Homo sapiens_hsa053400.53572936
78Type II diabetes mellitus_Homo sapiens_hsa049300.52013541
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51204294
80VEGF signaling pathway_Homo sapiens_hsa043700.50239649
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.48910092
82p53 signaling pathway_Homo sapiens_hsa041150.47902870
83Dorso-ventral axis formation_Homo sapiens_hsa043200.47041901
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.46848301
85Other glycan degradation_Homo sapiens_hsa005110.46307569
86Prostate cancer_Homo sapiens_hsa052150.42405774
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41780394
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.41503035
89Fructose and mannose metabolism_Homo sapiens_hsa000510.41280530
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41154987
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.40139993
92Endocytosis_Homo sapiens_hsa041440.40104044
93Complement and coagulation cascades_Homo sapiens_hsa046100.39616969
94Thyroid cancer_Homo sapiens_hsa052160.39345072
95mTOR signaling pathway_Homo sapiens_hsa041500.38890954
96Melanoma_Homo sapiens_hsa052180.38471115
97Prolactin signaling pathway_Homo sapiens_hsa049170.37533224
98Platelet activation_Homo sapiens_hsa046110.37054654
99Pathways in cancer_Homo sapiens_hsa052000.35736091
100ErbB signaling pathway_Homo sapiens_hsa040120.35419869
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35022440
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32232786
103Acute myeloid leukemia_Homo sapiens_hsa052210.31723136
104Vibrio cholerae infection_Homo sapiens_hsa051100.30157806
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.29258353
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27894019
107Ether lipid metabolism_Homo sapiens_hsa005650.27729131
108Sphingolipid metabolism_Homo sapiens_hsa006000.27322062
109HIF-1 signaling pathway_Homo sapiens_hsa040660.25132814
110Epstein-Barr virus infection_Homo sapiens_hsa051690.24962876
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24562008
112Small cell lung cancer_Homo sapiens_hsa052220.24030280
113Pancreatic cancer_Homo sapiens_hsa052120.23617350
114Proteoglycans in cancer_Homo sapiens_hsa052050.20866333
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18624145
116Chronic myeloid leukemia_Homo sapiens_hsa052200.17324310
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17275455
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17158227
119MAPK signaling pathway_Homo sapiens_hsa040100.16431019
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16113544
121FoxO signaling pathway_Homo sapiens_hsa040680.14939153
122Synaptic vesicle cycle_Homo sapiens_hsa047210.14055235
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11381279
124Vitamin digestion and absorption_Homo sapiens_hsa049770.10098626
125HTLV-I infection_Homo sapiens_hsa051660.09748569
126Adherens junction_Homo sapiens_hsa045200.08908109
127Insulin resistance_Homo sapiens_hsa049310.08689566
128TGF-beta signaling pathway_Homo sapiens_hsa043500.08507329
129Fatty acid biosynthesis_Homo sapiens_hsa000610.07798374
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07311376
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.07263251

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