SLC7A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.37150650
2L-phenylalanine catabolic process (GO:0006559)6.37150650
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.93884220
4L-phenylalanine metabolic process (GO:0006558)5.93884220
5aromatic amino acid family catabolic process (GO:0009074)5.70656692
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.34703794
7protein carboxylation (GO:0018214)5.24777360
8peptidyl-glutamic acid carboxylation (GO:0017187)5.24777360
9indole-containing compound catabolic process (GO:0042436)5.10640320
10indolalkylamine catabolic process (GO:0046218)5.10640320
11tryptophan catabolic process (GO:0006569)5.10640320
12complement activation, alternative pathway (GO:0006957)5.07722635
13urea metabolic process (GO:0019627)5.00974612
14urea cycle (GO:0000050)5.00974612
15tryptophan metabolic process (GO:0006568)4.89261981
16bile acid biosynthetic process (GO:0006699)4.87941254
17kynurenine metabolic process (GO:0070189)4.86480070
18negative regulation of protein activation cascade (GO:2000258)4.66315970
19regulation of protein activation cascade (GO:2000257)4.62842173
20alpha-linolenic acid metabolic process (GO:0036109)4.59218678
21nitrogen cycle metabolic process (GO:0071941)4.56833030
22high-density lipoprotein particle remodeling (GO:0034375)4.50302398
23negative regulation of fibrinolysis (GO:0051918)4.38724988
24regulation of complement activation (GO:0030449)4.37977105
25regulation of fibrinolysis (GO:0051917)4.33515384
26glyoxylate metabolic process (GO:0046487)4.29825063
27cysteine metabolic process (GO:0006534)4.24803297
28plasma lipoprotein particle clearance (GO:0034381)4.20174685
29bile acid metabolic process (GO:0008206)4.19261807
30negative regulation of complement activation (GO:0045916)4.19024422
31epoxygenase P450 pathway (GO:0019373)4.14663815
32sulfur amino acid catabolic process (GO:0000098)4.14623000
33reverse cholesterol transport (GO:0043691)4.14007720
34homocysteine metabolic process (GO:0050667)4.13536161
35plasma lipoprotein particle remodeling (GO:0034369)4.12811832
36protein-lipid complex remodeling (GO:0034368)4.12811832
37macromolecular complex remodeling (GO:0034367)4.12811832
38phospholipid efflux (GO:0033700)4.06869951
39tyrosine metabolic process (GO:0006570)4.06850905
40positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.04372181
41aromatic amino acid family metabolic process (GO:0009072)4.04209012
42regulation of cholesterol esterification (GO:0010872)4.01683292
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.90196246
44aldehyde catabolic process (GO:0046185)3.88390142
45regulation of triglyceride catabolic process (GO:0010896)3.83649638
46exogenous drug catabolic process (GO:0042738)3.83050280
47cholesterol efflux (GO:0033344)3.78541142
48triglyceride homeostasis (GO:0070328)3.78193268
49acylglycerol homeostasis (GO:0055090)3.78193268
50serine family amino acid catabolic process (GO:0009071)3.76128252
51low-density lipoprotein particle remodeling (GO:0034374)3.74466793
52indolalkylamine metabolic process (GO:0006586)3.71619360
53omega-hydroxylase P450 pathway (GO:0097267)3.66761424
54negative regulation of sterol transport (GO:0032372)3.64879436
55negative regulation of cholesterol transport (GO:0032375)3.64879436
56COPII vesicle coating (GO:0048208)3.62616167
57acute-phase response (GO:0006953)3.61616190
58ethanol oxidation (GO:0006069)3.61400736
59cellular zinc ion homeostasis (GO:0006882)3.60477388
60alpha-amino acid catabolic process (GO:1901606)3.60288069
61bile acid and bile salt transport (GO:0015721)3.57510456
62cellular glucuronidation (GO:0052695)3.57504701
63positive regulation of lipid catabolic process (GO:0050996)3.55768644
64amino-acid betaine metabolic process (GO:0006577)3.55105932
65cellular biogenic amine catabolic process (GO:0042402)3.53126544
66amine catabolic process (GO:0009310)3.53126544
67fibrinolysis (GO:0042730)3.51561935
68opsonization (GO:0008228)3.49220398
69lysine metabolic process (GO:0006553)3.46777137
70lysine catabolic process (GO:0006554)3.46777137
71plasma lipoprotein particle assembly (GO:0034377)3.46068853
72phospholipid homeostasis (GO:0055091)3.41144632
73coenzyme catabolic process (GO:0009109)3.39141682
74cofactor catabolic process (GO:0051187)3.38591432
75arginine metabolic process (GO:0006525)3.38047215
76uronic acid metabolic process (GO:0006063)3.38000313
77glucuronate metabolic process (GO:0019585)3.38000313
78macroautophagy (GO:0016236)3.37603428
79response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.36784345
80negative regulation of humoral immune response (GO:0002921)3.33008235
81imidazole-containing compound metabolic process (GO:0052803)3.32811432
82dicarboxylic acid biosynthetic process (GO:0043650)3.32312770
83ethanol metabolic process (GO:0006067)3.31942391
84plasma lipoprotein particle organization (GO:0071827)3.31164387
85positive regulation of hormone metabolic process (GO:0032352)3.29335008
86intestinal cholesterol absorption (GO:0030299)3.29059232
87embryonic retina morphogenesis in camera-type eye (GO:0060059)3.28976928
88hydrogen peroxide biosynthetic process (GO:0050665)3.27563822
89glutamate metabolic process (GO:0006536)3.26923151
90cellular amino acid catabolic process (GO:0009063)3.26427299
91benzene-containing compound metabolic process (GO:0042537)3.26199917
92protein activation cascade (GO:0072376)3.25269716
93cellular modified amino acid catabolic process (GO:0042219)3.24839402
94lipoprotein metabolic process (GO:0042157)3.24266451
95glycogen catabolic process (GO:0005980)3.23819977
96regulation of cholesterol homeostasis (GO:2000188)3.21902085
97complement activation (GO:0006956)3.21249440
98NAD biosynthetic process (GO:0009435)3.18091601
99biotin metabolic process (GO:0006768)3.15822173
100protein-lipid complex assembly (GO:0065005)3.13381375
101cellular ketone body metabolic process (GO:0046950)3.13361583
102protein-lipid complex subunit organization (GO:0071825)3.13146139
103desmosome organization (GO:0002934)3.13063730
104blood coagulation, intrinsic pathway (GO:0007597)3.11558954
105complement activation, classical pathway (GO:0006958)3.11307191
106cholesterol homeostasis (GO:0042632)3.11090974
107sterol homeostasis (GO:0055092)3.08016358
108very-low-density lipoprotein particle assembly (GO:0034379)3.06633151
109phenylpropanoid metabolic process (GO:0009698)3.02879242
110nicotinamide nucleotide biosynthetic process (GO:0019359)3.02513734
111pyridine nucleotide biosynthetic process (GO:0019363)3.02513734
112positive regulation of hemostasis (GO:1900048)3.01264817
113positive regulation of blood coagulation (GO:0030194)3.01264817
114positive regulation of triglyceride lipase activity (GO:0061365)2.99367473
115positive regulation of lipoprotein lipase activity (GO:0051006)2.99367473
116regulation of bile acid biosynthetic process (GO:0070857)2.98645730
117intestinal epithelial cell development (GO:0060576)2.98576742
118low-density lipoprotein particle clearance (GO:0034383)2.98109878
119drug catabolic process (GO:0042737)2.97690937
120glucan catabolic process (GO:0009251)2.93939336
121regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.93184078
122COPI coating of Golgi vesicle (GO:0048205)2.82804760
123Golgi transport vesicle coating (GO:0048200)2.82804760
124amino-acid betaine transport (GO:0015838)2.82413773
125carnitine transport (GO:0015879)2.82413773
126carnitine shuttle (GO:0006853)2.79975714
127cellular polysaccharide catabolic process (GO:0044247)2.74106065
128regulation of plasminogen activation (GO:0010755)2.72578785
129positive regulation of glycolytic process (GO:0045821)2.70670636
130positive regulation of gluconeogenesis (GO:0045722)2.70615366
131fatty acid homeostasis (GO:0055089)2.69230586
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.68107229
133quaternary ammonium group transport (GO:0015697)2.65552477
134skeletal muscle contraction (GO:0003009)2.64668559
135vitamin transmembrane transport (GO:0035461)2.64513845
136regulation of apoptotic cell clearance (GO:2000425)2.61257447
137regulation of type B pancreatic cell apoptotic process (GO:2000674)2.59845569
138plasma membrane repair (GO:0001778)2.59136663
139carnitine transmembrane transport (GO:1902603)2.59093053
140zinc ion transmembrane transport (GO:0071577)2.58859387
141zinc ion homeostasis (GO:0055069)2.58637118
142regulation of humoral immune response (GO:0002920)2.53085019
143heme transport (GO:0015886)2.49485840
144positive regulation of steroid metabolic process (GO:0045940)2.48651142
145exocrine pancreas development (GO:0031017)2.45687149
146skeletal muscle adaptation (GO:0043501)2.45504506
147peptide hormone processing (GO:0016486)2.42671358
148toxin transport (GO:1901998)2.41894339
149fatty acid transmembrane transport (GO:1902001)2.40725844
150polysaccharide catabolic process (GO:0000272)2.40054042
151positive regulation of cellular amine metabolic process (GO:0033240)2.39820252
152drug metabolic process (GO:0017144)2.39665041
153glutamine family amino acid catabolic process (GO:0009065)2.39399009
154positive regulation of hormone biosynthetic process (GO:0046886)2.39255277
155positive regulation of macroautophagy (GO:0016239)2.39079606
156regulation of hexokinase activity (GO:1903299)2.38828192
157regulation of glucokinase activity (GO:0033131)2.38828192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.22914707
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.68154698
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.64263321
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.60132552
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.38609963
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.60900496
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.04302429
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.90519293
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.28827740
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.26229317
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18368477
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.01306883
13ZNF263_19887448_ChIP-Seq_K562_Human2.76753769
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.74780842
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65400754
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.59945095
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27804261
18AHR_22903824_ChIP-Seq_MCF-7_Human2.22458196
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.21195045
20GATA1_22025678_ChIP-Seq_K562_Human2.16157350
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10816774
22* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.95539117
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.93565440
24ARNT_22903824_ChIP-Seq_MCF-7_Human1.91052826
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.89700999
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88229848
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86488656
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83710847
29* GATA3_24758297_ChIP-Seq_MCF-7_Human1.82323118
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.80972014
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74731910
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73898185
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68436017
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59706075
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54929720
36* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.54684064
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50533747
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49606032
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46836542
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.45935707
41ER_23166858_ChIP-Seq_MCF-7_Human1.45710810
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37920186
43* GATA6_25053715_ChIP-Seq_YYC3_Human1.31359562
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31321646
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29079952
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28458909
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28458909
48HTT_18923047_ChIP-ChIP_STHdh_Human1.26554274
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.26386280
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.25503119
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.25366695
52CLOCK_20551151_ChIP-Seq_293T_Human1.24231794
53RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19909770
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17256425
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14957301
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13153898
57HNF4A_19822575_ChIP-Seq_HepG2_Human1.10970955
58* TBX20_22080862_ChIP-Seq_HEART_Mouse1.07957203
59* TBX20_22328084_ChIP-Seq_HEART_Mouse1.07957203
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07427332
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.06060955
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04130057
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03413470
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01312839
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.00155937
66SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99756612
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96474488
68AR_21909140_ChIP-Seq_LNCAP_Human0.96052193
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92985815
70* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91615088
71RACK7_27058665_Chip-Seq_MCF-7_Human0.89516173
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89054805
73SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86487371
74RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86286080
75* GATA4_25053715_ChIP-Seq_YYC3_Human0.85514177
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85035486
77SALL1_21062744_ChIP-ChIP_HESCs_Human0.84968194
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84938509
79SMAD4_21799915_ChIP-Seq_A2780_Human0.84279145
80TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84202515
81RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84090261
82MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83475244
83* SOX2_20726797_ChIP-Seq_SW620_Human0.81707608
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80966591
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80753957
86CDX2_22108803_ChIP-Seq_LS180_Human0.80003935
87* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79723936
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78125581
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77523679
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77285656
91* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76727995
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76293708
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76251777
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76118873
95STAT3_23295773_ChIP-Seq_U87_Human0.74797769
96* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.74607348
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74241557
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74219552
99BRD4_27068464_Chip-Seq_AML-cells_Mouse0.73996280
100ISL1_27105846_Chip-Seq_CPCs_Mouse0.73412437
101NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73328336
102* FOXA1_25552417_ChIP-Seq_VCAP_Human0.72820520
103SMAD3_21741376_ChIP-Seq_EPCs_Human0.72731842
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72307459
105SOX2_18555785_Chip-Seq_ESCs_Mouse0.72049612
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71926043
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71177206
108WT1_25993318_ChIP-Seq_PODOCYTE_Human0.70606015
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.70257462
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.69996097
111VDR_24787735_ChIP-Seq_THP-1_Human0.69763209
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.69589868
113KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69423862
114CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69382428
115TRIM28_21343339_ChIP-Seq_HEK293_Human0.68359617
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67686626
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67552540
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.66144885
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.64827233
120* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63642467
121GATA1_19941826_ChIP-Seq_K562_Human0.63230773
122PU_27001747_Chip-Seq_BMDM_Mouse0.62873452
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.62776929
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.62014300
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.61003085
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60743727
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58109136
128GATA2_19941826_ChIP-Seq_K562_Human0.57877087
129EGR1_19032775_ChIP-ChIP_M12_Human0.56800884
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.55694876
131TP63_23658742_ChIP-Seq_EP156T_Human0.55489133
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.55467825
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.55205597
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.54662497
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.54455180
136AUTS2_25519132_ChIP-Seq_293T-REX_Human0.53856842
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53105568
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52935575
139GATA3_26560356_Chip-Seq_TH2_Human0.52783884
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.52701804
141AR_20517297_ChIP-Seq_VCAP_Human0.51644766
142CJUN_26792858_Chip-Seq_BT549_Human0.51067978
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.50586138
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.50458826
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49761591
146SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.48688155
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48606888
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.47490217
149* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.47396786
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.46806410
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.46623669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.83026090
2MP0005360_urolithiasis6.00702187
3MP0005085_abnormal_gallbladder_physiolo5.18921748
4MP0005365_abnormal_bile_salt5.11867298
5MP0009780_abnormal_chondrocyte_physiolo4.52832001
6MP0003195_calcinosis4.12179503
7MP0008875_abnormal_xenobiotic_pharmacok4.01361813
8MP0003252_abnormal_bile_duct3.52990591
9MP0009840_abnormal_foam_cell3.16742845
10MP0003806_abnormal_nucleotide_metabolis3.15886256
11MP0010329_abnormal_lipoprotein_level2.90929682
12MP0005083_abnormal_biliary_tract2.77049323
13MP0010234_abnormal_vibrissa_follicle2.54892694
14MP0000013_abnormal_adipose_tissue2.47183620
15MP0005332_abnormal_amino_acid2.38928619
16MP0002138_abnormal_hepatobiliary_system2.33303488
17MP0003191_abnormal_cellular_cholesterol2.19511145
18MP0002837_dystrophic_cardiac_calcinosis2.13016099
19MP0001666_abnormal_nutrient_absorption2.13000271
20MP0003724_increased_susceptibility_to1.98945895
21MP0003122_maternal_imprinting1.98914740
22MP0000003_abnormal_adipose_tissue1.98717795
23MP0000609_abnormal_liver_physiology1.96727519
24MP0004019_abnormal_vitamin_homeostasis1.89198197
25MP0003436_decreased_susceptibility_to1.88922073
26MP0002118_abnormal_lipid_homeostasis1.86738336
27MP0003123_paternal_imprinting1.82619988
28MP0004264_abnormal_extraembryonic_tissu1.79618390
29MP0004233_abnormal_muscle_weight1.78089227
30MP0003941_abnormal_skin_development1.75664610
31MP0005319_abnormal_enzyme/_coenzyme1.73140464
32MP0009764_decreased_sensitivity_to1.70640693
33MP0010678_abnormal_skin_adnexa1.65369100
34MP0003868_abnormal_feces_composition1.63914617
35MP0001661_extended_life_span1.59695780
36MP0004145_abnormal_muscle_electrophysio1.58717754
37MP0000383_abnormal_hair_follicle1.56446458
38MP0006082_CNS_inflammation1.53973204
39MP0005058_abnormal_lysosome_morphology1.51887351
40MP0009785_altered_susceptibility_to1.46429042
41MP0003186_abnormal_redox_activity1.45942132
42MP0002269_muscular_atrophy1.45318418
43MP0001764_abnormal_homeostasis1.45024434
44MP0008469_abnormal_protein_level1.43444136
45MP0000751_myopathy1.40330686
46MP0003646_muscle_fatigue1.39794681
47MP0005584_abnormal_enzyme/coenzyme_acti1.38681650
48MP0004036_abnormal_muscle_relaxation1.35957756
49MP0001835_abnormal_antigen_presentation1.34218910
50MP0002419_abnormal_innate_immunity1.33058755
51MP0009643_abnormal_urine_homeostasis1.32526242
52MP0000604_amyloidosis1.31707209
53MP0003303_peritoneal_inflammation1.28869462
54MP0002108_abnormal_muscle_morphology1.28186303
55MP0004270_analgesia1.25282045
56MP0005646_abnormal_pituitary_gland1.23351827
57MP0003075_altered_response_to1.22382249
58MP0009763_increased_sensitivity_to1.22212841
59MP0004087_abnormal_muscle_fiber1.20770877
60MP0002254_reproductive_system_inflammat1.18940863
61MP0003879_abnormal_hair_cell1.18876997
62MP0003705_abnormal_hypodermis_morpholog1.17045087
63MP0000462_abnormal_digestive_system1.15660573
64MP0005464_abnormal_platelet_physiology1.13654141
65MP0003656_abnormal_erythrocyte_physiolo1.13481929
66MP0005369_muscle_phenotype1.12727009
67MP0005375_adipose_tissue_phenotype1.12300330
68MP0002078_abnormal_glucose_homeostasis1.12134321
69MP0005025_abnormal_response_to1.12020497
70MP0002106_abnormal_muscle_physiology1.11956615
71MP0005330_cardiomyopathy1.10779842
72MP0005451_abnormal_body_composition1.10493840
73MP0002148_abnormal_hypersensitivity_rea1.08304331
74MP0003690_abnormal_glial_cell1.07974369
75MP0000598_abnormal_liver_morphology1.07656452
76MP0000749_muscle_degeneration1.05685489
77MP0009697_abnormal_copulation1.05091317
78MP0000747_muscle_weakness1.04824101
79MP0002693_abnormal_pancreas_physiology1.03401176
80MP0001533_abnormal_skeleton_physiology1.02273517
81MP0005645_abnormal_hypothalamus_physiol1.02145336
82MP0003283_abnormal_digestive_organ1.01842438
83MP0005220_abnormal_exocrine_pancreas0.99000825
84MP0004782_abnormal_surfactant_physiolog0.98120124
85MP0002332_abnormal_exercise_endurance0.97702118
86MP0005000_abnormal_immune_tolerance0.97587864
87MP0010352_gastrointestinal_tract_polyps0.97547722
88MP0001845_abnormal_inflammatory_respons0.96571478
89MP0005535_abnormal_body_temperature0.96234290
90MP0005409_darkened_coat_color0.95677532
91MP0005408_hypopigmentation0.95015440
92MP0004947_skin_inflammation0.94480570
93MP0009642_abnormal_blood_homeostasis0.93961765
94MP0005636_abnormal_mineral_homeostasis0.93047866
95MP0004130_abnormal_muscle_cell0.92098187
96MP0000639_abnormal_adrenal_gland0.88501478
97MP0005166_decreased_susceptibility_to0.88340722
98MP0001790_abnormal_immune_system0.87595248
99MP0005387_immune_system_phenotype0.87595248
100MP0003172_abnormal_lysosome_physiology0.87481707
101MP0001756_abnormal_urination0.86079355
102MP0002896_abnormal_bone_mineralization0.84502735
103MP0002163_abnormal_gland_morphology0.84497590
104MP0003183_abnormal_peptide_metabolism0.84486800
105MP0001944_abnormal_pancreas_morphology0.83307729
106MP0002160_abnormal_reproductive_system0.81807512
107MP0005379_endocrine/exocrine_gland_phen0.81294075
108MP0009672_abnormal_birth_weight0.80886468
109MP0004272_abnormal_basement_membrane0.80402689
110MP0003011_delayed_dark_adaptation0.80292119
111MP0004215_abnormal_myocardial_fiber0.79344454
112MP0002796_impaired_skin_barrier0.78439673
113MP0000759_abnormal_skeletal_muscle0.78198638
114MP0002127_abnormal_cardiovascular_syste0.78088898
115MP0005647_abnormal_sex_gland0.77385300
116MP0001765_abnormal_ion_homeostasis0.75991386
117MP0005334_abnormal_fat_pad0.75820078
118MP0000685_abnormal_immune_system0.75166951
119MP0004084_abnormal_cardiac_muscle0.74915025
120MP0002168_other_aberrant_phenotype0.73260986
121MP0005670_abnormal_white_adipose0.73218081
122MP0005076_abnormal_cell_differentiation0.73213733
123MP0001853_heart_inflammation0.73032230
124MP0005376_homeostasis/metabolism_phenot0.71734108
125MP0005084_abnormal_gallbladder_morpholo0.71017307
126MP0002971_abnormal_brown_adipose0.70728084
127MP0003890_abnormal_embryonic-extraembry0.70056523
128MP0009703_decreased_birth_body0.69462712
129MP0005164_abnormal_response_to0.69379497
130MP0002938_white_spotting0.68975039
131MP0009765_abnormal_xenobiotic_induced0.67893251
132MP0010368_abnormal_lymphatic_system0.67469407
133MP0003300_gastrointestinal_ulcer0.66965250
134MP0005448_abnormal_energy_balance0.66893156
135MP0002928_abnormal_bile_duct0.66525638
136MP0000566_synostosis0.66172788
137MP0005167_abnormal_blood-brain_barrier0.65839073
138MP0003566_abnormal_cell_adhesion0.65819062
139MP0002723_abnormal_immune_serum0.65554141
140MP0002136_abnormal_kidney_physiology0.64376753
141MP0010630_abnormal_cardiac_muscle0.64272525
142MP0002009_preneoplasia0.63875979
143MP0004043_abnormal_pH_regulation0.62157329
144MP0000427_abnormal_hair_cycle0.61984957
145MP0005620_abnormal_muscle_contractility0.61441570
146MP0004510_myositis0.60395470
147MP0002452_abnormal_antigen_presenting0.58708637
148MP0002090_abnormal_vision0.58481939
149MP0002998_abnormal_bone_remodeling0.57252625
150MP0002877_abnormal_melanocyte_morpholog0.56424727
151MP0001800_abnormal_humoral_immune0.55696385
152MP0002876_abnormal_thyroid_physiology0.55160529
153MP0010386_abnormal_urinary_bladder0.53505223
154MP0003953_abnormal_hormone_level0.53001184
155MP0005395_other_phenotype0.52452181
156MP0005248_abnormal_Harderian_gland0.51404994
157MP0002909_abnormal_adrenal_gland0.49437522

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.59597213
2Intrahepatic cholestasis (HP:0001406)6.09045681
3Prolonged partial thromboplastin time (HP:0003645)5.98422163
4Deep venous thrombosis (HP:0002625)5.98066523
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.90055546
6Xanthomatosis (HP:0000991)5.52819666
7Complement deficiency (HP:0004431)4.99826210
8Recurrent gram-negative bacterial infections (HP:0005420)4.89780726
9Hypobetalipoproteinemia (HP:0003563)4.89778561
10Joint hemorrhage (HP:0005261)4.86348347
11Hyperlipoproteinemia (HP:0010980)4.61036724
12Abnormality of the common coagulation pathway (HP:0010990)4.54322919
13Hypoglycemic coma (HP:0001325)4.47315176
14Epidermoid cyst (HP:0200040)4.28379171
15Systemic lupus erythematosus (HP:0002725)4.00194136
16Abnormality of complement system (HP:0005339)3.87080266
17Hypolipoproteinemia (HP:0010981)3.84246530
18Ketosis (HP:0001946)3.77134044
19Muscle fiber inclusion bodies (HP:0100299)3.72433656
20Hypoglycemic seizures (HP:0002173)3.71817259
21Conjugated hyperbilirubinemia (HP:0002908)3.69132401
22Exercise-induced myalgia (HP:0003738)3.68219534
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.67782280
24Abnormality of the intrinsic pathway (HP:0010989)3.67373860
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.58221674
26Fat malabsorption (HP:0002630)3.56511244
27Nemaline bodies (HP:0003798)3.54337485
28Hypoalphalipoproteinemia (HP:0003233)3.54187230
29Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.50848007
30Hyperammonemia (HP:0001987)3.49479419
31Myocardial infarction (HP:0001658)3.49358144
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.47041356
33Hypercholesterolemia (HP:0003124)3.38145051
34Abnormality of methionine metabolism (HP:0010901)3.34499751
35Hyperinsulinemic hypoglycemia (HP:0000825)3.30695342
36Ketoacidosis (HP:0001993)3.24729352
37Abnormality of pyrimidine metabolism (HP:0004353)3.21514883
38Glomerulonephritis (HP:0000099)3.13525819
39Abnormality of aspartate family amino acid metabolism (HP:0010899)3.12115049
40Hyperphosphatemia (HP:0002905)3.04789944
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.03716212
42Asymmetry of the thorax (HP:0001555)3.00179829
43Skin nodule (HP:0200036)2.99282543
44Hyperglycinemia (HP:0002154)2.98927404
45Exercise-induced muscle cramps (HP:0003710)2.97456266
46Mitral stenosis (HP:0001718)2.89749026
47J-shaped sella turcica (HP:0002680)2.85244435
48Eczematoid dermatitis (HP:0000976)2.84252144
49Right ventricular cardiomyopathy (HP:0011663)2.83589453
50Abnormality of nucleobase metabolism (HP:0010932)2.81946824
51Symptomatic seizures (HP:0011145)2.81648906
52Hyperglycemia (HP:0003074)2.78579829
53Muscle hypertrophy of the lower extremities (HP:0008968)2.76402626
54Hyperbilirubinemia (HP:0002904)2.75454021
55Proximal tubulopathy (HP:0000114)2.72035663
56Calf muscle hypertrophy (HP:0008981)2.70245437
57Hyperglycinuria (HP:0003108)2.69884015
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67446340
59Hepatocellular carcinoma (HP:0001402)2.64504828
60Abnormality of purine metabolism (HP:0004352)2.62162795
61Type 1 muscle fiber predominance (HP:0003803)2.59465768
62Abnormality of glycine metabolism (HP:0010895)2.59135058
63Abnormality of serine family amino acid metabolism (HP:0010894)2.59135058
64Gingival bleeding (HP:0000225)2.58103610
65Steatorrhea (HP:0002570)2.57967013
66Late onset (HP:0003584)2.53278219
67Recurrent bacterial skin infections (HP:0005406)2.52115909
68Insulin-resistant diabetes mellitus (HP:0000831)2.50108504
69Abnormality of fatty-acid metabolism (HP:0004359)2.49403192
70Esophageal varix (HP:0002040)2.43463401
71Testicular neoplasm (HP:0010788)2.41276338
72Spontaneous abortion (HP:0005268)2.40343963
73Abnormality of calcium-phosphate metabolism (HP:0100530)2.38779817
74Menorrhagia (HP:0000132)2.34611480
75Irritability (HP:0000737)2.33963195
76Hyporeflexia of lower limbs (HP:0002600)2.31870939
77Congenital malformation of the right heart (HP:0011723)2.31301192
78Double outlet right ventricle (HP:0001719)2.31301192
79Bundle branch block (HP:0011710)2.27456494
80Myoglobinuria (HP:0002913)2.25487525
81Papillary thyroid carcinoma (HP:0002895)2.23229213
82Amyloidosis (HP:0011034)2.20193667
83Hemorrhage of the eye (HP:0011885)2.20003281
84EMG: myopathic abnormalities (HP:0003458)2.19777398
85Generalized aminoaciduria (HP:0002909)2.17976108
86Nephritis (HP:0000123)2.17673478
87Vascular calcification (HP:0004934)2.16438549
88Abnormality of the calf musculature (HP:0001430)2.14538306
89Autoimmune thrombocytopenia (HP:0001973)2.11375614
90Vacuolated lymphocytes (HP:0001922)2.11113930
91Pancreatitis (HP:0001733)2.10920547
92Septate vagina (HP:0001153)2.10581392
93Pheochromocytoma (HP:0002666)2.08898399
94Retinal atrophy (HP:0001105)2.08767371
95Abnormal gallbladder morphology (HP:0012437)2.06894318
96Recurrent abscess formation (HP:0002722)2.06297503
97Osteomalacia (HP:0002749)2.05878984
98Abnormality of endocrine pancreas physiology (HP:0012093)2.04967268
99Abnormality of the pancreatic islet cells (HP:0006476)2.04967268
100Abnormality of vitamin metabolism (HP:0100508)2.03820537
101Abnormality of serum amino acid levels (HP:0003112)2.02183246
102Metabolic acidosis (HP:0001942)2.01998982
103Axonal loss (HP:0003447)2.01158786
104Abnormality of proline metabolism (HP:0010907)2.00780777
105Hydroxyprolinuria (HP:0003080)2.00780777
106Joint swelling (HP:0001386)2.00646094
107Mucopolysacchariduria (HP:0008155)2.00488678
108Urinary glycosaminoglycan excretion (HP:0003541)2.00488678
109Acanthocytosis (HP:0001927)1.99364052
110Delayed CNS myelination (HP:0002188)1.98720774
111Hyperkalemia (HP:0002153)1.98154101
112Sensorimotor neuropathy (HP:0007141)1.97697056
113Abnormal enzyme/coenzyme activity (HP:0012379)1.96782236
114Cardiovascular calcification (HP:0011915)1.95173005
115Thrombophlebitis (HP:0004418)1.94318689
116Hypochromic microcytic anemia (HP:0004840)1.93454046
117Tetraparesis (HP:0002273)1.93109306
118Spastic diplegia (HP:0001264)1.92873397
119Elevated alkaline phosphatase (HP:0003155)1.92764347
120Abnormal pancreas size (HP:0012094)1.91556593
121Gout (HP:0001997)1.90265359
122Round ear (HP:0100830)1.88891425
123Pancreatic islet-cell hyperplasia (HP:0004510)1.88146301
124Rhabdomyolysis (HP:0003201)1.88087050
125Nausea (HP:0002018)1.87476175
126Dysostosis multiplex (HP:0000943)1.87260703
127Abnormality of iron homeostasis (HP:0011031)1.87211462
128Abnormality of transition element cation homeostasis (HP:0011030)1.87203241
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86610605
130Abnormality of polysaccharide metabolism (HP:0011012)1.86610605
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86610605
132Ulnar deviation of the wrist (HP:0003049)1.85933906
133Stroke (HP:0001297)1.84593934
134Menstrual irregularities (HP:0000858)1.84141765
135Thyroid carcinoma (HP:0002890)1.82703125
136Abnormality of macrophages (HP:0004311)1.82680024
137Macroorchidism (HP:0000053)1.80036145
138Rimmed vacuoles (HP:0003805)1.80028535
139Enlarged penis (HP:0000040)1.78603066
140Large for gestational age (HP:0001520)1.76060980
141Fetal akinesia sequence (HP:0001989)1.72601270
142Neuroendocrine neoplasm (HP:0100634)1.72472534
143Distal arthrogryposis (HP:0005684)1.70348056
144Hyperphosphaturia (HP:0003109)1.69869170
145Sudden death (HP:0001699)1.69730329
146Fair hair (HP:0002286)1.69402307
147Rickets (HP:0002748)1.68766915
148Hypothermia (HP:0002045)1.67844782
149Increased circulating renin level (HP:0000848)1.67096608
150Myopathic facies (HP:0002058)1.66889778
151Popliteal pterygium (HP:0009756)1.66336639
152Flat acetabular roof (HP:0003180)1.62222462
153Back pain (HP:0003418)1.61385089
154Microglossia (HP:0000171)1.60826054
155Goiter (HP:0000853)1.60105128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.19277534
2ERN14.02608656
3INSRR3.72461248
4TAOK33.59359400
5EEF2K3.25994855
6PHKG23.20592595
7PHKG13.20592595
8PBK3.08315658
9MAP3K142.99655576
10SIK12.96929200
11FGFR42.93857585
12BCKDK2.77838227
13SCYL22.73961301
14MAPK152.73288486
15MAPKAPK32.70646525
16MST1R2.62606690
17PIK3CA2.55715821
18IRAK32.55580528
19RIPK42.51410641
20TYK22.47457208
21TRPM72.46744161
22PIK3CG2.41879310
23TBK12.27886175
24RPS6KB22.21153395
25ERBB42.17290301
26EPHA22.09380437
27AKT32.07248303
28TTN1.99836650
29JAK11.98430823
30FGFR21.93405637
31BLK1.78618524
32FRK1.77073005
33NEK61.65376009
34MST41.65215302
35FER1.60764161
36STK38L1.59086312
37IKBKE1.55609450
38NEK91.53727470
39JAK31.51263021
40ABL21.50727553
41IRAK41.50650402
42EPHA31.48304991
43JAK21.44561703
44CSK1.43779688
45STK391.42060299
46WNK41.39830611
47MUSK1.39486226
48WNK31.39346733
49ICK1.36335757
50LATS21.32672001
51FLT31.30627291
52EIF2AK11.30430820
53LATS11.26683334
54TRIB31.23001867
55MAP3K131.22675726
56PTK61.15461499
57IRAK11.15304064
58NME11.11565429
59IKBKB1.08713503
60MET1.07901243
61EIF2AK31.07346167
62MAP2K61.07083851
63PDK21.01930368
64RPS6KB11.01899801
65NTRK31.01360734
66RIPK11.00706465
67BMX0.99387171
68MAP3K10.98696928
69FGFR30.95125415
70MAP3K120.95023674
71MAPK110.94651844
72CAMK1G0.94406785
73CHUK0.92200101
74IRAK20.89935456
75MAP3K20.88802439
76DAPK20.86877689
77MTOR0.86446159
78EPHB10.86307694
79AKT20.84810638
80CAMK2D0.83886485
81ERBB30.83051381
82BRD40.82777827
83MAP2K40.80102773
84STK380.79119615
85MAP2K20.77952642
86PNCK0.67609595
87PKN20.67103051
88CAMK2G0.66765759
89CDK120.66210456
90FGFR10.64226166
91ZAP700.62806286
92MAP3K50.62653433
93PRKCH0.62135089
94KIT0.61637398
95BMPR20.61439101
96SGK20.61096773
97MAP3K90.60669806
98LYN0.60242347
99TXK0.57811197
100PDGFRA0.57153937
101DYRK1B0.56148382
102IGF1R0.55431612
103MAP3K100.55337604
104CAMK1D0.55119342
105YES10.55115691
106MAPK120.54539894
107ERBB20.54037827
108PRKACG0.53528826
109MAP4K10.52377692
110PRKAA20.52084297
111PRKCZ0.51880332
112EGFR0.51765866
113PDPK10.51647560
114CSNK1E0.50389983
115ABL10.49120066
116PTK20.48993302
117MAPKAPK50.48850712
118GSK3A0.47633243
119MARK30.45953256
120PASK0.44916287
121SGK2230.44603110
122SGK4940.44603110
123PRKD30.44419014
124STK240.44186309
125PRKCQ0.43495988
126SGK30.42426854
127PRKCD0.41803861
128STK30.41624752
129HIPK20.41546372
130PRKCI0.40393132
131HCK0.39627659
132OXSR10.36971136
133CSNK1D0.36236986
134SYK0.35892090
135KSR20.34970534
136NUAK10.34652008
137PRKAA10.34443267
138NTRK10.34179864
139MAP3K30.33507988
140RET0.32955186
141CDK60.32269772
142SMG10.31041742
143PRKACB0.30735644
144NLK0.30389547
145GRK10.29823495
146MATK0.29738270
147EIF2AK20.29454404
148RPS6KA40.28951482
149KDR0.28940340
150LCK0.28698985
151MAPK40.28656062
152PDK10.28226561
153SGK10.27138285
154LMTK20.26461447
155MAP3K40.26350460
156MAP2K10.25689781
157CSF1R0.25372312
158PDGFRB0.24510037
159BTK0.24451488
160MAP3K70.23562077
161PAK30.23535978
162PRKCE0.22130873

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.36291803
2Nitrogen metabolism_Homo sapiens_hsa009103.66839022
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21782030
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07928291
5Arginine biosynthesis_Homo sapiens_hsa002203.07864830
6Complement and coagulation cascades_Homo sapiens_hsa046103.04421421
7Staphylococcus aureus infection_Homo sapiens_hsa051502.81829844
8Tryptophan metabolism_Homo sapiens_hsa003802.56121743
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.29328131
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26877312
11Fatty acid degradation_Homo sapiens_hsa000712.18407481
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14274276
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99641705
14Peroxisome_Homo sapiens_hsa041461.97249469
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93924793
16Caffeine metabolism_Homo sapiens_hsa002321.86446233
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83968333
18Histidine metabolism_Homo sapiens_hsa003401.81302826
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80378996
20PPAR signaling pathway_Homo sapiens_hsa033201.73802150
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72163602
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.71178902
23Chemical carcinogenesis_Homo sapiens_hsa052041.65551583
24Butanoate metabolism_Homo sapiens_hsa006501.62234307
25Selenocompound metabolism_Homo sapiens_hsa004501.59499459
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55451465
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.51089005
28Sulfur metabolism_Homo sapiens_hsa009201.50410693
29Fatty acid metabolism_Homo sapiens_hsa012121.49718151
30Phenylalanine metabolism_Homo sapiens_hsa003601.47463444
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45188477
32beta-Alanine metabolism_Homo sapiens_hsa004101.41877559
33Retinol metabolism_Homo sapiens_hsa008301.41666496
34ABC transporters_Homo sapiens_hsa020101.40864400
35Glucagon signaling pathway_Homo sapiens_hsa049221.35506215
36Circadian rhythm_Homo sapiens_hsa047101.34425514
37Starch and sucrose metabolism_Homo sapiens_hsa005001.33606477
38Bile secretion_Homo sapiens_hsa049761.33047144
39Propanoate metabolism_Homo sapiens_hsa006401.27785095
40Folate biosynthesis_Homo sapiens_hsa007901.27121086
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23728572
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23606113
43Steroid biosynthesis_Homo sapiens_hsa001001.22565036
44Tyrosine metabolism_Homo sapiens_hsa003501.21396893
45Fat digestion and absorption_Homo sapiens_hsa049751.00770761
46Prion diseases_Homo sapiens_hsa050200.98442043
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98250891
48Insulin secretion_Homo sapiens_hsa049110.95566588
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90853819
50AMPK signaling pathway_Homo sapiens_hsa041520.89108372
51Sphingolipid metabolism_Homo sapiens_hsa006000.87696265
52Fatty acid elongation_Homo sapiens_hsa000620.86996346
53Thyroid hormone synthesis_Homo sapiens_hsa049180.86802443
54Type I diabetes mellitus_Homo sapiens_hsa049400.86716566
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84925927
56Insulin signaling pathway_Homo sapiens_hsa049100.84446527
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82336558
58Graft-versus-host disease_Homo sapiens_hsa053320.79826969
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.79808826
60Other glycan degradation_Homo sapiens_hsa005110.78326590
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77003126
62Vitamin digestion and absorption_Homo sapiens_hsa049770.76365579
63Legionellosis_Homo sapiens_hsa051340.75927916
64Arginine and proline metabolism_Homo sapiens_hsa003300.74807614
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74527726
66Tight junction_Homo sapiens_hsa045300.70100874
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69664195
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68721990
69Pyruvate metabolism_Homo sapiens_hsa006200.68326079
70Vibrio cholerae infection_Homo sapiens_hsa051100.68022377
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67611218
72Biosynthesis of amino acids_Homo sapiens_hsa012300.66764156
73Dilated cardiomyopathy_Homo sapiens_hsa054140.64485386
74Lysine degradation_Homo sapiens_hsa003100.63163901
75Leishmaniasis_Homo sapiens_hsa051400.62968848
76Pertussis_Homo sapiens_hsa051330.62911275
77Ovarian steroidogenesis_Homo sapiens_hsa049130.62511280
78Thyroid cancer_Homo sapiens_hsa052160.62504326
79Fructose and mannose metabolism_Homo sapiens_hsa000510.61147330
80Carbon metabolism_Homo sapiens_hsa012000.61117675
81Lysosome_Homo sapiens_hsa041420.60972723
82Sulfur relay system_Homo sapiens_hsa041220.59627030
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59513557
84Malaria_Homo sapiens_hsa051440.55905476
85N-Glycan biosynthesis_Homo sapiens_hsa005100.52975148
86Pancreatic secretion_Homo sapiens_hsa049720.52827732
87Insulin resistance_Homo sapiens_hsa049310.52065764
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51774193
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51309662
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.50384111
91African trypanosomiasis_Homo sapiens_hsa051430.50023062
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48263687
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.47884096
94Glycerolipid metabolism_Homo sapiens_hsa005610.43744025
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43576690
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43540616
97mTOR signaling pathway_Homo sapiens_hsa041500.42421107
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.41801944
99Fatty acid biosynthesis_Homo sapiens_hsa000610.39558273
100Type II diabetes mellitus_Homo sapiens_hsa049300.38571799
101Arachidonic acid metabolism_Homo sapiens_hsa005900.38379832
102Inositol phosphate metabolism_Homo sapiens_hsa005620.38051849
103TNF signaling pathway_Homo sapiens_hsa046680.36401298
104Allograft rejection_Homo sapiens_hsa053300.35283432
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35275361
106Tuberculosis_Homo sapiens_hsa051520.34385558
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33938554
108Renin secretion_Homo sapiens_hsa049240.33471244
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33263091
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32987221
111Rheumatoid arthritis_Homo sapiens_hsa053230.32692439
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31073695
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30574797
114One carbon pool by folate_Homo sapiens_hsa006700.29287963
115Pentose phosphate pathway_Homo sapiens_hsa000300.29062019
116Glutathione metabolism_Homo sapiens_hsa004800.27531306
117Phagosome_Homo sapiens_hsa041450.26295490
118Vitamin B6 metabolism_Homo sapiens_hsa007500.24158382
119Metabolic pathways_Homo sapiens_hsa011000.23613968
120Linoleic acid metabolism_Homo sapiens_hsa005910.23371717
121Influenza A_Homo sapiens_hsa051640.22286995
122Galactose metabolism_Homo sapiens_hsa000520.21869522
123Amoebiasis_Homo sapiens_hsa051460.20666594
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20164459
125Osteoclast differentiation_Homo sapiens_hsa043800.19798683
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19770059
127Asthma_Homo sapiens_hsa053100.16711274
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15335700
129Hepatitis C_Homo sapiens_hsa051600.14978532
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14459841

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