SLC7A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)6.43933484
2regulation of gene silencing by miRNA (GO:0060964)6.43933484
3regulation of gene silencing by RNA (GO:0060966)6.43933484
4L-serine metabolic process (GO:0006563)5.56287885
5DNA unwinding involved in DNA replication (GO:0006268)4.96278464
6folic acid-containing compound biosynthetic process (GO:0009396)4.90831004
7DNA replication initiation (GO:0006270)4.61101562
8histone arginine methylation (GO:0034969)4.57690630
9establishment of integrated proviral latency (GO:0075713)4.50972048
10formation of translation preinitiation complex (GO:0001731)4.50919419
11DNA replication-dependent nucleosome organization (GO:0034723)4.50356525
12DNA replication-dependent nucleosome assembly (GO:0006335)4.50356525
13nucleobase biosynthetic process (GO:0046112)4.48784888
14peptidyl-arginine omega-N-methylation (GO:0035247)4.35198700
15IMP biosynthetic process (GO:0006188)4.25024748
16nuclear pore organization (GO:0006999)4.24444191
17ribosome biogenesis (GO:0042254)4.23613927
18regulation of helicase activity (GO:0051095)4.18707747
19pre-miRNA processing (GO:0031054)4.03874043
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.01774739
21purine nucleobase biosynthetic process (GO:0009113)4.01026067
22regulation of cell fate specification (GO:0042659)3.99955001
23mitotic metaphase plate congression (GO:0007080)3.95471343
24histone exchange (GO:0043486)3.93383665
25DNA replication-independent nucleosome assembly (GO:0006336)3.90657339
26DNA replication-independent nucleosome organization (GO:0034724)3.90657339
27ribosome assembly (GO:0042255)3.88429744
28DNA strand elongation involved in DNA replication (GO:0006271)3.87634384
29protein localization to kinetochore (GO:0034501)3.85860325
30maturation of SSU-rRNA (GO:0030490)3.85012211
31somatic hypermutation of immunoglobulin genes (GO:0016446)3.83539294
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.83539294
33negative regulation of sister chromatid segregation (GO:0033046)3.74544232
34negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.74544232
35negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.74544232
36negative regulation of mitotic sister chromatid segregation (GO:0033048)3.74544232
37negative regulation of mitotic sister chromatid separation (GO:2000816)3.74544232
38ribonucleoprotein complex biogenesis (GO:0022613)3.71838925
39peptidyl-arginine methylation (GO:0018216)3.71741486
40peptidyl-arginine N-methylation (GO:0035246)3.71741486
41heterochromatin organization (GO:0070828)3.70674647
42mitotic nuclear envelope disassembly (GO:0007077)3.67108895
43regulation of histone H3-K9 methylation (GO:0051570)3.65622214
44mitotic sister chromatid segregation (GO:0000070)3.65545482
45DNA strand elongation (GO:0022616)3.64934623
46nuclear pore complex assembly (GO:0051292)3.62211620
47regulation of translational fidelity (GO:0006450)3.61908913
48IMP metabolic process (GO:0046040)3.60447944
49serine family amino acid biosynthetic process (GO:0009070)3.53023305
50negative regulation of histone methylation (GO:0031061)3.51443317
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.50880083
52regulation of mitotic spindle checkpoint (GO:1903504)3.50880083
53protein complex localization (GO:0031503)3.49855825
54DNA geometric change (GO:0032392)3.48801520
55DNA duplex unwinding (GO:0032508)3.48174078
56regulation of gene silencing (GO:0060968)3.47855601
57paraxial mesoderm development (GO:0048339)3.46480780
58spindle checkpoint (GO:0031577)3.45759093
59mitotic spindle checkpoint (GO:0071174)3.45704499
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.44447970
61nuclear envelope disassembly (GO:0051081)3.44096908
62membrane disassembly (GO:0030397)3.44096908
63ribosomal large subunit biogenesis (GO:0042273)3.43197449
64negative regulation of gene silencing (GO:0060969)3.42424646
65spliceosomal snRNP assembly (GO:0000387)3.41477408
66DNA replication checkpoint (GO:0000076)3.41435594
67tRNA aminoacylation for protein translation (GO:0006418)3.39979892
68histone H4-K12 acetylation (GO:0043983)3.36336826
69metaphase plate congression (GO:0051310)3.34509634
70anterior/posterior axis specification, embryo (GO:0008595)3.33045836
71negative regulation of translation, ncRNA-mediated (GO:0040033)3.32292231
72regulation of translation, ncRNA-mediated (GO:0045974)3.32292231
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.32292231
74establishment of viral latency (GO:0019043)3.31791151
75telomere maintenance via semi-conservative replication (GO:0032201)3.31496075
76mitotic spindle assembly checkpoint (GO:0007094)3.30193267
77ATP-dependent chromatin remodeling (GO:0043044)3.30160337
78pseudouridine synthesis (GO:0001522)3.29331277
79DNA ligation (GO:0006266)3.28111318
80regulation of chromosome segregation (GO:0051983)3.27223869
81tRNA aminoacylation (GO:0043039)3.26282690
82amino acid activation (GO:0043038)3.26282690
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25728891
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25728891
85rRNA processing (GO:0006364)3.25317634
86regulation of mitotic sister chromatid separation (GO:0010965)3.24391660
87regulation of mitotic sister chromatid segregation (GO:0033047)3.24391660
88regulation of sister chromatid segregation (GO:0033045)3.24391660
89chaperone-mediated protein complex assembly (GO:0051131)3.24016803
90cellular protein complex localization (GO:0034629)3.23422130
91maturation of 5.8S rRNA (GO:0000460)3.23081328
92spindle assembly checkpoint (GO:0071173)3.21893737
93rRNA modification (GO:0000154)3.20163904
94negative regulation of DNA-dependent DNA replication (GO:2000104)3.18799844
95negative regulation of androgen receptor signaling pathway (GO:0060766)3.17349869
96cullin deneddylation (GO:0010388)3.16308350
97lung-associated mesenchyme development (GO:0060484)3.16044520
98regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.15891619
99DNA strand renaturation (GO:0000733)3.15847297
100rRNA metabolic process (GO:0016072)3.15284595
101regulation of chromatin silencing (GO:0031935)3.14856209
102negative regulation of telomerase activity (GO:0051974)3.14307530
103cell fate commitment involved in formation of primary germ layer (GO:0060795)3.13687134
104sister chromatid segregation (GO:0000819)3.12592098
105regulation of translational termination (GO:0006449)3.11541429
106non-recombinational repair (GO:0000726)3.10990957
107double-strand break repair via nonhomologous end joining (GO:0006303)3.10990957
108negative regulation of mitosis (GO:0045839)3.09916510
109lysine metabolic process (GO:0006553)3.07256327
110lysine catabolic process (GO:0006554)3.07256327
111protein K6-linked ubiquitination (GO:0085020)3.05695310
112DNA damage response, detection of DNA damage (GO:0042769)3.05022749
113pteridine-containing compound biosynthetic process (GO:0042559)3.03465083
114nodal signaling pathway (GO:0038092)3.01751783
115determination of adult lifespan (GO:0008340)2.98865336
116translational initiation (GO:0006413)2.97711239
117protein localization to chromosome, centromeric region (GO:0071459)2.97437651
118spliceosomal complex assembly (GO:0000245)2.97258614
119chromatin assembly or disassembly (GO:0006333)2.96803892
120positive regulation of SMAD protein import into nucleus (GO:0060391)2.96299758
121negative regulation of DNA recombination (GO:0045910)2.96111424
122positive regulation of chromosome segregation (GO:0051984)2.95487696
123chromatin remodeling at centromere (GO:0031055)2.95461119
124regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95325731
125regulation of centrosome cycle (GO:0046605)2.95261873
126single strand break repair (GO:0000012)2.92997365
127ribosomal small subunit biogenesis (GO:0042274)2.92858614
128regulation of cell fate commitment (GO:0010453)2.91719305
129telomere maintenance via telomere lengthening (GO:0010833)2.90581350
130DNA double-strand break processing (GO:0000729)2.90172196
131regulation of telomere maintenance via telomerase (GO:0032210)2.88758905
132translational termination (GO:0006415)2.88748754
133telomere maintenance via telomerase (GO:0007004)2.88091887
134tetrahydrofolate metabolic process (GO:0046653)2.86759740
135mitotic G2/M transition checkpoint (GO:0044818)2.86550764
136viral transcription (GO:0019083)2.86045122
137establishment of chromosome localization (GO:0051303)2.82861802
138convergent extension (GO:0060026)2.82680901
139transcription-coupled nucleotide-excision repair (GO:0006283)2.81968463
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80075029
141negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.79882304
142spliceosomal tri-snRNP complex assembly (GO:0000244)2.77074337
143regulation of centriole replication (GO:0046599)2.76829261
144negative regulation of chromosome segregation (GO:0051985)2.75902559
145establishment of apical/basal cell polarity (GO:0035089)2.75885457
146CENP-A containing nucleosome assembly (GO:0034080)2.75132263
147telomere maintenance via recombination (GO:0000722)2.74542704
148translational elongation (GO:0006414)2.72120186
149nucleotide-excision repair, DNA gap filling (GO:0006297)2.71841255
150cellular component biogenesis (GO:0044085)2.70417820
151ncRNA catabolic process (GO:0034661)2.69287035
152protein deneddylation (GO:0000338)2.69227912
153mitotic recombination (GO:0006312)2.68356380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.65958738
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.55884330
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.68723642
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.40440311
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.40440311
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.40440311
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10814634
8* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.09499425
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07132630
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.03834470
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.00589470
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.87659879
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78250122
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.61506542
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56764524
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.53841857
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.51590223
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49638055
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.43019743
20* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.40128450
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33660239
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31960160
23* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.30646877
24* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.27987120
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25574387
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24972735
27POU5F1_16153702_ChIP-ChIP_HESCs_Human2.23358508
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.21458514
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15059306
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12855910
31XRN2_22483619_ChIP-Seq_HELA_Human2.09986672
32SOX2_18555785_ChIP-Seq_MESCs_Mouse2.08341016
33CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08317525
34GABP_17652178_ChIP-ChIP_JURKAT_Human2.08285242
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04027767
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03915077
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00528078
38* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.97828910
39* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.97722032
40* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.96833389
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.95516371
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90570281
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88911690
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87257672
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.86565491
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84760829
47* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.83070584
48* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.76233102
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.72532483
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72441045
51* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70996245
52TTF2_22483619_ChIP-Seq_HELA_Human1.66069949
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65245236
54VDR_23849224_ChIP-Seq_CD4+_Human1.58351185
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55897890
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.54238426
57AR_21909140_ChIP-Seq_LNCAP_Human1.53933072
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49613442
59* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48951931
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48244763
61* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.46754384
62FOXP3_21729870_ChIP-Seq_TREG_Human1.45512460
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44809899
64DCP1A_22483619_ChIP-Seq_HELA_Human1.43310622
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.43040506
66* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.40546849
67* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40275874
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39891345
69GABP_19822575_ChIP-Seq_HepG2_Human1.38661529
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36015295
71* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.35379222
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34008776
73* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.31555862
74* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.30795690
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29796523
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.29471867
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25766759
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.24757388
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22184669
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21013068
81* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20752815
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.20020381
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18894099
84* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17165616
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16221387
86KDM5A_27292631_Chip-Seq_BREAST_Human1.14250172
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13667203
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12818501
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10190253
90* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10094939
91ELK1_19687146_ChIP-ChIP_HELA_Human1.08814779
92* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08277519
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.06425285
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05448553
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04400999
96* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03248296
97IRF1_19129219_ChIP-ChIP_H3396_Human1.01790317
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.01430661
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01123944
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00651127
101SOX2_16153702_ChIP-ChIP_HESCs_Human0.99526557
102CIITA_25753668_ChIP-Seq_RAJI_Human0.98711120
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98430419
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.97566333
105NANOG_16518401_ChIP-PET_MESCs_Mouse0.97410967
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95911299
107ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95446715
108* KAP1_27257070_Chip-Seq_ESCs_Mouse0.94496772
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93896316
110PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93855946
111TFEB_21752829_ChIP-Seq_HELA_Human0.92145306
112MYC_18940864_ChIP-ChIP_HL60_Human0.89492127
113EWS_26573619_Chip-Seq_HEK293_Human0.89428400
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88835872
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85500442
116TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84784210
117FUS_26573619_Chip-Seq_HEK293_Human0.84466716
118TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83427199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.49292773
2MP0004957_abnormal_blastocyst_morpholog4.17809817
3MP0003693_abnormal_embryo_hatching3.94022367
4MP0008057_abnormal_DNA_replication3.65843391
5MP0010094_abnormal_chromosome_stability3.64414472
6MP0003111_abnormal_nucleus_morphology3.57402157
7MP0004133_heterotaxia3.40842224
8MP0003123_paternal_imprinting3.37786059
9MP0003077_abnormal_cell_cycle3.20588235
10MP0003890_abnormal_embryonic-extraembry2.67690201
11MP0008877_abnormal_DNA_methylation2.64230653
12MP0002653_abnormal_ependyma_morphology2.57788225
13MP0008058_abnormal_DNA_repair2.56596999
14MP0003806_abnormal_nucleotide_metabolis2.47045197
15MP0003283_abnormal_digestive_organ2.41134838
16MP0008932_abnormal_embryonic_tissue2.37827519
17MP0001730_embryonic_growth_arrest2.27690921
18MP0010352_gastrointestinal_tract_polyps2.22308960
19MP0000350_abnormal_cell_proliferation2.17688494
20MP0006292_abnormal_olfactory_placode2.16012603
21MP0003119_abnormal_digestive_system2.15902388
22MP0003121_genomic_imprinting2.11184441
23MP0003567_abnormal_fetal_cardiomyocyte2.06228315
24MP0010030_abnormal_orbit_morphology1.93079915
25MP0002084_abnormal_developmental_patter1.86844268
26MP0005380_embryogenesis_phenotype1.85035500
27MP0001672_abnormal_embryogenesis/_devel1.85035500
28MP0002085_abnormal_embryonic_tissue1.81451651
29MP0003941_abnormal_skin_development1.77862235
30MP0008007_abnormal_cellular_replicative1.77505856
31MP0001697_abnormal_embryo_size1.70949164
32MP0003718_maternal_effect1.69674462
33MP0003136_yellow_coat_color1.68135970
34MP0004197_abnormal_fetal_growth/weight/1.63340547
35MP0001293_anophthalmia1.62612032
36MP0003984_embryonic_growth_retardation1.55113283
37MP0001188_hyperpigmentation1.53739723
38MP0005394_taste/olfaction_phenotype1.53168735
39MP0005499_abnormal_olfactory_system1.53168735
40MP0004233_abnormal_muscle_weight1.53141448
41MP0002088_abnormal_embryonic_growth/wei1.52445247
42MP0002080_prenatal_lethality1.49272304
43MP0002938_white_spotting1.46313461
44MP0003786_premature_aging1.43881844
45MP0003878_abnormal_ear_physiology1.43746050
46MP0005377_hearing/vestibular/ear_phenot1.43746050
47MP0002086_abnormal_extraembryonic_tissu1.39084612
48MP0003787_abnormal_imprinting1.37975246
49MP0000566_synostosis1.36011249
50MP0010307_abnormal_tumor_latency1.31749531
51MP0008789_abnormal_olfactory_epithelium1.29632452
52MP0000579_abnormal_nail_morphology1.29352023
53MP0005266_abnormal_metabolism1.27412058
54MP0001529_abnormal_vocalization1.26349691
55MP0002332_abnormal_exercise_endurance1.25538830
56MP0003122_maternal_imprinting1.25061306
57MP0001299_abnormal_eye_distance/1.19690737
58MP0000537_abnormal_urethra_morphology1.08283339
59MP0002160_abnormal_reproductive_system1.07558730
60MP0003861_abnormal_nervous_system1.07158143
61MP0002210_abnormal_sex_determination1.06853877
62MP0003646_muscle_fatigue1.06708267
63MP0001145_abnormal_male_reproductive1.05045875
64MP0002111_abnormal_tail_morphology1.03702463
65MP0003315_abnormal_perineum_morphology1.02996204
66MP0006035_abnormal_mitochondrial_morpho1.02952640
67MP0001849_ear_inflammation1.02093461
68MP0002751_abnormal_autonomic_nervous1.00471282
69MP0002796_impaired_skin_barrier1.00030545
70MP0000313_abnormal_cell_death0.98502294
71MP0005076_abnormal_cell_differentiation0.97779678
72MP0001485_abnormal_pinna_reflex0.95489510
73MP0009697_abnormal_copulation0.95362224
74MP0001286_abnormal_eye_development0.95218232
75MP0001177_atelectasis0.95103277
76MP0004142_abnormal_muscle_tone0.90973212
77MP0006072_abnormal_retinal_apoptosis0.89915210
78MP0003938_abnormal_ear_development0.89431997
79MP0009703_decreased_birth_body0.88945750
80MP0003937_abnormal_limbs/digits/tail_de0.87388321
81MP0004858_abnormal_nervous_system0.86464518
82MP0004272_abnormal_basement_membrane0.86457756
83MP0009672_abnormal_birth_weight0.84665908
84MP0002736_abnormal_nociception_after0.84045302
85MP0000432_abnormal_head_morphology0.82232308
86MP0008872_abnormal_physiological_respon0.81788466
87MP0000358_abnormal_cell_content/0.81683567
88MP0002092_abnormal_eye_morphology0.80622165
89MP0002090_abnormal_vision0.80561041
90MP0000653_abnormal_sex_gland0.80495104
91MP0005367_renal/urinary_system_phenotyp0.80195253
92MP0000516_abnormal_urinary_system0.80195253
93MP0002233_abnormal_nose_morphology0.77395401
94MP0001984_abnormal_olfaction0.76796670
95MP0002249_abnormal_larynx_morphology0.76485960
96MP0000762_abnormal_tongue_morphology0.76297755
97MP0001929_abnormal_gametogenesis0.75741946
98MP0003186_abnormal_redox_activity0.75645583
99MP0008770_decreased_survivor_rate0.75395216
100MP0002127_abnormal_cardiovascular_syste0.75117654
101MP0002277_abnormal_respiratory_mucosa0.74705424
102MP0000049_abnormal_middle_ear0.74678119
103MP0002697_abnormal_eye_size0.71798183
104MP0005389_reproductive_system_phenotype0.71784670
105MP0002019_abnormal_tumor_incidence0.71735453
106MP0003755_abnormal_palate_morphology0.71702024
107MP0002282_abnormal_trachea_morphology0.67972842
108MP0005384_cellular_phenotype0.67553817
109MP0000750_abnormal_muscle_regeneration0.66824214
110MP0002114_abnormal_axial_skeleton0.66073228
111MP0003935_abnormal_craniofacial_develop0.65400475
112MP0004264_abnormal_extraembryonic_tissu0.65008879
113MP0003705_abnormal_hypodermis_morpholog0.64269521
114MP0003698_abnormal_male_reproductive0.62853238
115MP0003936_abnormal_reproductive_system0.62320435
116MP0000490_abnormal_crypts_of0.61687529
117MP0000428_abnormal_craniofacial_morphol0.60924618
118MP0000647_abnormal_sebaceous_gland0.60062458
119MP0000631_abnormal_neuroendocrine_gland0.59302577
120MP0003942_abnormal_urinary_system0.58960205
121MP0003115_abnormal_respiratory_system0.58955970
122MP0009053_abnormal_anal_canal0.58937282
123MP0000467_abnormal_esophagus_morphology0.58517108
124MP0002269_muscular_atrophy0.57371200
125MP0002152_abnormal_brain_morphology0.57181468
126MP0009379_abnormal_foot_pigmentation0.56436101
127MP0001346_abnormal_lacrimal_gland0.56404362
128MP0002081_perinatal_lethality0.56357880
129MP0005391_vision/eye_phenotype0.56219900

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.84723386
2Abnormality of the labia minora (HP:0012880)4.70580012
3Supernumerary spleens (HP:0009799)3.99141615
4Birth length less than 3rd percentile (HP:0003561)3.97450942
5Breast hypoplasia (HP:0003187)3.67715436
6Abnormality of the astrocytes (HP:0100707)3.55406629
7Astrocytoma (HP:0009592)3.55406629
8Medulloblastoma (HP:0002885)3.55381721
9Hepatoblastoma (HP:0002884)3.54423064
10Absent radius (HP:0003974)3.34641629
11Colon cancer (HP:0003003)3.33305229
12Nephroblastoma (Wilms tumor) (HP:0002667)3.31115193
13Carpal bone hypoplasia (HP:0001498)3.29289640
14Abnormality of abdominal situs (HP:0011620)3.28933823
15Abdominal situs inversus (HP:0003363)3.28933823
16Cortical dysplasia (HP:0002539)3.27040754
17Aplasia involving forearm bones (HP:0009822)3.19744081
18Absent forearm bone (HP:0003953)3.19744081
19Choanal stenosis (HP:0000452)3.12422058
20Embryonal renal neoplasm (HP:0011794)3.10839122
21Agnosia (HP:0010524)3.10306305
22Rhabdomyosarcoma (HP:0002859)3.08606644
23Selective tooth agenesis (HP:0001592)3.05783795
24Aplasia/hypoplasia of the humerus (HP:0006507)3.01293734
25Rib fusion (HP:0000902)2.97569517
26Irregular epiphyses (HP:0010582)2.93771198
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89375059
28Oral leukoplakia (HP:0002745)2.87627462
29Glioma (HP:0009733)2.85184437
30Neoplasm of the oral cavity (HP:0100649)2.84561075
31Bilateral microphthalmos (HP:0007633)2.83644720
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.83269690
33Abnormal number of incisors (HP:0011064)2.78310090
34Maternal diabetes (HP:0009800)2.77546857
35Cerebral hypomyelination (HP:0006808)2.76651756
36Absent septum pellucidum (HP:0001331)2.75551451
37Short humerus (HP:0005792)2.72442291
38Chromsome breakage (HP:0040012)2.69376337
39Absent thumb (HP:0009777)2.67561238
40Abnormality of the septum pellucidum (HP:0007375)2.62122864
41Neoplasm of striated muscle (HP:0009728)2.61011507
42Hyperglycinemia (HP:0002154)2.59685929
43Multiple enchondromatosis (HP:0005701)2.58387329
44Rectal fistula (HP:0100590)2.57931126
45Rectovaginal fistula (HP:0000143)2.57931126
46Esophageal atresia (HP:0002032)2.55465428
47Missing ribs (HP:0000921)2.55241104
48Patellar aplasia (HP:0006443)2.51713865
49Reticulocytopenia (HP:0001896)2.48388621
50Rough bone trabeculation (HP:0100670)2.48169403
51Hyperglycinuria (HP:0003108)2.43789563
52Bifid tongue (HP:0010297)2.41180490
53Abnormality of the anterior horn cell (HP:0006802)2.40952104
54Degeneration of anterior horn cells (HP:0002398)2.40952104
55Abnormality of glycine metabolism (HP:0010895)2.33842443
56Abnormality of serine family amino acid metabolism (HP:0010894)2.33842443
57Trismus (HP:0000211)2.31819676
58Asplenia (HP:0001746)2.30192330
59Aplasia/Hypoplasia of the patella (HP:0006498)2.29282503
60Ectopic kidney (HP:0000086)2.27411944
61Impulsivity (HP:0100710)2.24773982
62Increased nuchal translucency (HP:0010880)2.24280651
63Abnormality of the salivary glands (HP:0010286)2.24108965
64Shawl scrotum (HP:0000049)2.23997076
65Meckel diverticulum (HP:0002245)2.21291621
66Pancreatic islet-cell hyperplasia (HP:0004510)2.19041301
67Abnormality of the lower motor neuron (HP:0002366)2.19030740
68Chronic bronchitis (HP:0004469)2.18715746
69Duplication of thumb phalanx (HP:0009942)2.16836275
70Partial duplication of thumb phalanx (HP:0009944)2.16170010
71Hypoglycemic seizures (HP:0002173)2.16024761
72Aqueductal stenosis (HP:0002410)2.15876248
73Abnormality of the duodenum (HP:0002246)2.15855723
74Abnormality of the ileum (HP:0001549)2.15098218
75Myelomeningocele (HP:0002475)2.14268530
76Abnormal hair whorl (HP:0010721)2.13825283
77Triphalangeal thumb (HP:0001199)2.13598086
78Abnormality of the preputium (HP:0100587)2.12779287
79Septo-optic dysplasia (HP:0100842)2.11596281
80Horseshoe kidney (HP:0000085)2.11392277
81Aplasia/Hypoplasia of the spleen (HP:0010451)2.11377916
82Intestinal fistula (HP:0100819)2.11265497
83Adenoma sebaceum (HP:0009720)2.09548703
84Angiofibromas (HP:0010615)2.09548703
85Tracheoesophageal fistula (HP:0002575)2.08521479
86Short hallux (HP:0010109)2.08311978
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08247607
88Breast aplasia (HP:0100783)2.07965508
89Homocystinuria (HP:0002156)2.07889263
90Abnormality of homocysteine metabolism (HP:0010919)2.07889263
91Stenosis of the external auditory canal (HP:0000402)2.07443380
92Metaphyseal cupping (HP:0003021)2.06758420
93Abnormality of serum amino acid levels (HP:0003112)2.05802333
94Glossoptosis (HP:0000162)2.05398886
95Neoplasm of the colon (HP:0100273)2.04450523
96Vaginal fistula (HP:0004320)2.03569319
97Generalized hypotonia (HP:0001290)2.03424850
98Sex reversal (HP:0012245)2.02204690
99Abnormal sex determination (HP:0012244)2.02204690
100Anophthalmia (HP:0000528)2.01463191
101Vertebral clefting (HP:0008428)2.01310884
102Aplasia/Hypoplasia of the hallux (HP:0008362)2.00740230
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.99396713
104Cellular immunodeficiency (HP:0005374)1.97513110
105Neoplasm of the pancreas (HP:0002894)1.97173018
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.96393621
107Fused cervical vertebrae (HP:0002949)1.96392044
108Supernumerary bones of the axial skeleton (HP:0009144)1.95924779
109Facial cleft (HP:0002006)1.95611398
110Intestinal atresia (HP:0011100)1.95406243
111Biliary tract neoplasm (HP:0100574)1.95113704
112Optic nerve hypoplasia (HP:0000609)1.92851515
113Abnormality of the clitoris (HP:0000056)1.92053354
114Embryonal neoplasm (HP:0002898)1.91865815
115Abnormal lung lobation (HP:0002101)1.91614470
116Basal cell carcinoma (HP:0002671)1.91250477
117Hypoplastic female external genitalia (HP:0012815)1.90183197
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.89097723
119Neoplasm of the adrenal cortex (HP:0100641)1.88458324
120Gastrointestinal atresia (HP:0002589)1.88454058
121Aplasia/Hypoplasia of the breasts (HP:0010311)1.87478571
122Premature ovarian failure (HP:0008209)1.86425680
123Abnormality of pyrimidine metabolism (HP:0004353)1.85639934
124Broad thumb (HP:0011304)1.85182014
125Premature graying of hair (HP:0002216)1.85065116
126Gastrointestinal carcinoma (HP:0002672)1.84640647
127Malignant gastrointestinal tract tumors (HP:0006749)1.84640647
128Hypoplasia of the pons (HP:0012110)1.83501558
129Mild short stature (HP:0003502)1.82699233
130Preaxial foot polydactyly (HP:0001841)1.82234225
131Duplicated collecting system (HP:0000081)1.82123755
132Abnormality of glycolysis (HP:0004366)1.82065173
133Increased serum pyruvate (HP:0003542)1.82065173
134Delayed puberty (HP:0000823)1.80678370
135Absent eyebrow (HP:0002223)1.80555129
136Vitreoretinal degeneration (HP:0000655)1.79820630
137Spastic diplegia (HP:0001264)1.79695573
138Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79560518
139Abnormal trabecular bone morphology (HP:0100671)1.78554158
140Abnormality of chromosome stability (HP:0003220)1.78350999
141Vertebral hypoplasia (HP:0008417)1.77790518
142Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77790518
143Partial duplication of the phalanx of hand (HP:0009999)1.76709209
144Hemivertebrae (HP:0002937)1.76592020
145Duodenal stenosis (HP:0100867)1.76061677
146Small intestinal stenosis (HP:0012848)1.76061677
147Spinal muscular atrophy (HP:0007269)1.75589274
148Sloping forehead (HP:0000340)1.75249298
149High anterior hairline (HP:0009890)1.74771708
150Vertebral fusion (HP:0002948)1.74435248
151Cutaneous syndactyly (HP:0012725)1.74322439
152Hypogonadotrophic hypogonadism (HP:0000044)1.74121560
153Tongue fasciculations (HP:0001308)1.74084017
154Absent eyelashes (HP:0000561)1.72859809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.28002156
2WEE13.90941272
3CDC73.87592586
4VRK23.45658579
5CDK123.37120120
6PNCK3.20124545
7EPHA23.06034207
8NEK12.96841536
9TSSK62.93204323
10TAF12.91914594
11TTK2.62962345
12TNIK2.52441293
13CDK192.47023469
14ZAK2.30670843
15MAP3K102.26238928
16EIF2AK12.14969098
17CDK71.96265282
18PLK11.95941112
19SRPK11.90867082
20RPS6KB21.80228068
21PLK31.78310436
22LATS21.73104021
23SMG11.72300968
24AKT31.66800124
25NEK21.61532278
26NUAK11.54929448
27PASK1.54339841
28TRIM281.48885466
29AURKA1.48841614
30TLK11.47820201
31CHEK21.44119996
32VRK11.40704795
33ATR1.36851144
34ALK1.36288479
35CHEK11.33921706
36BRD41.33702996
37EIF2AK31.31533020
38FGFR21.29527157
39PAK41.28483355
40PDK41.25339527
41PDK31.25339527
42TESK21.24463883
43AURKB1.21935012
44STK38L1.21585557
45MKNK21.20522505
46MKNK11.15758911
47GRK61.15163993
48PDK21.11918276
49PRKCI1.08642357
50SCYL21.06157989
51MAP3K81.05412488
52STK31.04334962
53MAP3K90.99710202
54CDK20.99546443
55NLK0.97919438
56NME10.94720686
57CSNK1G10.92792570
58ATM0.91808958
59CSNK1E0.91027336
60CSNK2A20.87895422
61FLT30.87261557
62CDK40.85245409
63TIE10.84550525
64ERBB40.83360945
65BMX0.82427835
66PLK40.81816058
67STK100.80122042
68DAPK10.79172326
69STK240.78736495
70DYRK20.75028979
71MAPKAPK30.72210118
72CAMK1G0.72080573
73BMPR1B0.71723297
74EIF2AK20.70666858
75CAMK1D0.69439306
76CDK10.69185813
77DYRK30.69139512
78BCR0.68018022
79FGFR10.66461463
80MET0.66082069
81AKT20.65154447
82CASK0.64275533
83PBK0.64121677
84CSNK2A10.62948570
85MST40.62054502
86CSNK1G20.61746176
87ACVR1B0.61354466
88BRSK20.60742345
89BRAF0.60384075
90OXSR10.59918207
91MAP3K40.59565662
92GRK50.59150199
93PAK10.58583061
94DDR20.56621961
95MTOR0.56054689
96PLK20.55363062
97CSNK1G30.54296853
98CSNK1D0.54037310
99BCKDK0.53242516
100PKN20.51423155
101BRSK10.48543918
102PIM10.47716220
103NME20.47043881
104CDK140.46917473
105EEF2K0.46792061
106PRKDC0.46543938
107CDK150.46505041
108TYRO30.46381708
109KDR0.45893995
110CDK11A0.45683465
111MAP3K110.44006842
112CDK180.43605762
113DYRK1A0.41952710
114WNK30.41908520
115ICK0.41488671
116MELK0.40860056
117STK40.39726288
118CDK60.38989109
119MAPK100.38869319
120YES10.37319042
121TESK10.36399513
122STK160.35660080
123GSK3B0.35564810
124MAPK140.34571946
125UHMK10.32453285
126CSNK1A1L0.32232146
127EGFR0.31691041
128TGFBR10.30712010
129LATS10.30636717
130DMPK0.30191423
131RPS6KA40.30023098
132FGR0.29707396
133PRKCG0.28361292

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.41805958
2Mismatch repair_Homo sapiens_hsa034304.41131178
3DNA replication_Homo sapiens_hsa030304.33236475
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.62475708
5One carbon pool by folate_Homo sapiens_hsa006703.53619596
6RNA transport_Homo sapiens_hsa030133.48584287
7Spliceosome_Homo sapiens_hsa030403.41242122
8RNA polymerase_Homo sapiens_hsa030203.35505708
9Ribosome_Homo sapiens_hsa030103.14789605
10Proteasome_Homo sapiens_hsa030502.97660353
11Nucleotide excision repair_Homo sapiens_hsa034202.70924380
12Homologous recombination_Homo sapiens_hsa034402.47283444
13Base excision repair_Homo sapiens_hsa034102.34733707
14Cell cycle_Homo sapiens_hsa041102.16498915
15Pyrimidine metabolism_Homo sapiens_hsa002402.13543521
16mRNA surveillance pathway_Homo sapiens_hsa030151.99013606
17Fanconi anemia pathway_Homo sapiens_hsa034601.98409476
18RNA degradation_Homo sapiens_hsa030181.86295335
19Basal transcription factors_Homo sapiens_hsa030221.66745877
20Steroid biosynthesis_Homo sapiens_hsa001001.63012662
21Non-homologous end-joining_Homo sapiens_hsa034501.61043982
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.59921532
23Biosynthesis of amino acids_Homo sapiens_hsa012301.59760204
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35568635
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.27175805
26Protein export_Homo sapiens_hsa030601.25287348
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22622439
28Oocyte meiosis_Homo sapiens_hsa041141.18976474
29Propanoate metabolism_Homo sapiens_hsa006401.17701967
30p53 signaling pathway_Homo sapiens_hsa041151.17015260
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16257755
32Purine metabolism_Homo sapiens_hsa002301.15384913
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12535212
34Huntingtons disease_Homo sapiens_hsa050161.07846199
35Fatty acid elongation_Homo sapiens_hsa000620.99359343
36Oxidative phosphorylation_Homo sapiens_hsa001900.96761957
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89697332
38Epstein-Barr virus infection_Homo sapiens_hsa051690.89582417
39Parkinsons disease_Homo sapiens_hsa050120.88562266
40Basal cell carcinoma_Homo sapiens_hsa052170.88311126
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87889349
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87237603
43Hippo signaling pathway_Homo sapiens_hsa043900.84844880
44Fructose and mannose metabolism_Homo sapiens_hsa000510.83126511
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82901368
46Vitamin digestion and absorption_Homo sapiens_hsa049770.82215014
47Carbon metabolism_Homo sapiens_hsa012000.79060414
48Selenocompound metabolism_Homo sapiens_hsa004500.78700455
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78245669
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77483835
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75997222
52Lysine degradation_Homo sapiens_hsa003100.75627936
53Systemic lupus erythematosus_Homo sapiens_hsa053220.71867450
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.68023225
55Hedgehog signaling pathway_Homo sapiens_hsa043400.64209645
56Thyroid cancer_Homo sapiens_hsa052160.63510261
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62938315
58Alcoholism_Homo sapiens_hsa050340.62648138
59TGF-beta signaling pathway_Homo sapiens_hsa043500.62299146
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61242493
61Viral carcinogenesis_Homo sapiens_hsa052030.60748980
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57156711
63Folate biosynthesis_Homo sapiens_hsa007900.56758952
64Nicotine addiction_Homo sapiens_hsa050330.53539424
65Synaptic vesicle cycle_Homo sapiens_hsa047210.51824797
66Arginine and proline metabolism_Homo sapiens_hsa003300.50755545
67Galactose metabolism_Homo sapiens_hsa000520.50107942
68Tight junction_Homo sapiens_hsa045300.50060670
69Pyruvate metabolism_Homo sapiens_hsa006200.49762468
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48188577
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47396062
72MicroRNAs in cancer_Homo sapiens_hsa052060.46395600
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45853958
74Collecting duct acid secretion_Homo sapiens_hsa049660.44256689
75Fatty acid metabolism_Homo sapiens_hsa012120.42345028
76beta-Alanine metabolism_Homo sapiens_hsa004100.39935958
77Wnt signaling pathway_Homo sapiens_hsa043100.38868746
78Glutathione metabolism_Homo sapiens_hsa004800.37340644
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37141696
80Phenylalanine metabolism_Homo sapiens_hsa003600.36246049
81Vitamin B6 metabolism_Homo sapiens_hsa007500.35884152
82Melanoma_Homo sapiens_hsa052180.35693566
83HIF-1 signaling pathway_Homo sapiens_hsa040660.35185225
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35034598
85Bladder cancer_Homo sapiens_hsa052190.34711912
86Colorectal cancer_Homo sapiens_hsa052100.33942601
87HTLV-I infection_Homo sapiens_hsa051660.33498524
88mTOR signaling pathway_Homo sapiens_hsa041500.32262931
89Vibrio cholerae infection_Homo sapiens_hsa051100.31907188
90Alzheimers disease_Homo sapiens_hsa050100.31685274
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30993968
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30950293
93Sulfur relay system_Homo sapiens_hsa041220.30341816
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.29133995
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28653448
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28120559
97N-Glycan biosynthesis_Homo sapiens_hsa005100.27522050
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27316575
99Metabolic pathways_Homo sapiens_hsa011000.24992777
100Fat digestion and absorption_Homo sapiens_hsa049750.22769405
101Retinol metabolism_Homo sapiens_hsa008300.21993275
102Pathways in cancer_Homo sapiens_hsa052000.21591191
103Fatty acid degradation_Homo sapiens_hsa000710.21419193
104Prostate cancer_Homo sapiens_hsa052150.19417970
105Notch signaling pathway_Homo sapiens_hsa043300.19365659
106Pentose phosphate pathway_Homo sapiens_hsa000300.18188451
107Cardiac muscle contraction_Homo sapiens_hsa042600.18031847
108Adherens junction_Homo sapiens_hsa045200.16996078
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16292459
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15897106
111Tyrosine metabolism_Homo sapiens_hsa003500.14918545
112Taste transduction_Homo sapiens_hsa047420.13751239
113Gap junction_Homo sapiens_hsa045400.13658231
114Melanogenesis_Homo sapiens_hsa049160.13047786
115Type I diabetes mellitus_Homo sapiens_hsa049400.13043919
116Ether lipid metabolism_Homo sapiens_hsa005650.12089075
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11966714
118Glucagon signaling pathway_Homo sapiens_hsa049220.11828864
119Phototransduction_Homo sapiens_hsa047440.10252356
120Arginine biosynthesis_Homo sapiens_hsa002200.10040932
121Starch and sucrose metabolism_Homo sapiens_hsa005000.09814372
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07968852
123Long-term depression_Homo sapiens_hsa047300.07560653
124Long-term potentiation_Homo sapiens_hsa047200.05955477
125Protein digestion and absorption_Homo sapiens_hsa049740.05418625
126Amphetamine addiction_Homo sapiens_hsa050310.03770423
127Herpes simplex infection_Homo sapiens_hsa051680.02880932
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01719182
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.01525309

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