SLC7A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.62109394
2desmosome organization (GO:0002934)5.91092853
3regulation of translational fidelity (GO:0006450)5.21979547
4nuclear pore complex assembly (GO:0051292)4.90605881
5nuclear pore organization (GO:0006999)4.74510932
6cell-substrate junction assembly (GO:0007044)4.73214090
7folic acid-containing compound biosynthetic process (GO:0009396)4.31122132
8heterochromatin organization (GO:0070828)4.27427728
9activation of Rac GTPase activity (GO:0032863)4.19177836
10regulation of translational termination (GO:0006449)4.15299532
11pre-miRNA processing (GO:0031054)4.13427609
12protein localization to kinetochore (GO:0034501)4.04597975
13cell-substrate adherens junction assembly (GO:0007045)4.00962513
14focal adhesion assembly (GO:0048041)4.00962513
15proline biosynthetic process (GO:0006561)3.88607355
16DNA unwinding involved in DNA replication (GO:0006268)3.83942553
17cellular protein complex localization (GO:0034629)3.75607579
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.75244478
19mitotic nuclear envelope disassembly (GO:0007077)3.67294195
20protein complex localization (GO:0031503)3.67074830
21epithelial cell-cell adhesion (GO:0090136)3.66702448
22pore complex assembly (GO:0046931)3.58268493
23membrane disassembly (GO:0030397)3.56148228
24nuclear envelope disassembly (GO:0051081)3.56148228
25bundle of His cell to Purkinje myocyte communication (GO:0086069)3.46575631
26protein retention in ER lumen (GO:0006621)3.40979610
27positive regulation of keratinocyte differentiation (GO:0045618)3.40900801
28chromatin assembly (GO:0031497)3.39431732
29atrioventricular valve morphogenesis (GO:0003181)3.36353118
30regulation of mammary gland epithelial cell proliferation (GO:0033599)3.34615767
31branching involved in salivary gland morphogenesis (GO:0060445)3.28360748
32establishment of apical/basal cell polarity (GO:0035089)3.28105311
33cytoskeletal anchoring at plasma membrane (GO:0007016)3.26530589
34protein localization to chromosome, centromeric region (GO:0071459)3.25799657
35dosage compensation (GO:0007549)3.25561031
36histone H2A monoubiquitination (GO:0035518)3.24033894
37peptidyl-arginine omega-N-methylation (GO:0035247)3.23716974
38histone H4-K12 acetylation (GO:0043983)3.21963362
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21315869
40RNA stabilization (GO:0043489)3.21119073
41mRNA stabilization (GO:0048255)3.21119073
42regulation of posttranscriptional gene silencing (GO:0060147)3.20170450
43regulation of gene silencing by miRNA (GO:0060964)3.20170450
44regulation of gene silencing by RNA (GO:0060966)3.20170450
45peptidyl-lysine dimethylation (GO:0018027)3.19836401
46sister chromatid segregation (GO:0000819)3.19661875
47spliceosomal tri-snRNP complex assembly (GO:0000244)3.18849711
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17562067
49planar cell polarity pathway involved in neural tube closure (GO:0090179)3.17496697
50gene silencing by RNA (GO:0031047)3.15176664
51dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.14802542
52DNA replication-dependent nucleosome assembly (GO:0006335)3.14182279
53DNA replication-dependent nucleosome organization (GO:0034723)3.14182279
54mitotic G1 DNA damage checkpoint (GO:0031571)3.12139968
55NLS-bearing protein import into nucleus (GO:0006607)3.11277057
56protein localization to endosome (GO:0036010)3.10690630
57negative regulation of histone methylation (GO:0031061)3.08167028
58regulation of early endosome to late endosome transport (GO:2000641)3.07693214
59mitotic sister chromatid segregation (GO:0000070)3.06783252
60L-serine metabolic process (GO:0006563)3.06330754
61regulation of RNA export from nucleus (GO:0046831)3.04205189
62mitotic chromosome condensation (GO:0007076)3.03204963
63embryonic process involved in female pregnancy (GO:0060136)3.02694353
64activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.01707193
65pentose-phosphate shunt (GO:0006098)3.01508721
66retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00773022
67positive regulation of nuclease activity (GO:0032075)3.00580628
68gonadal mesoderm development (GO:0007506)2.99605011
69regulation of translational elongation (GO:0006448)2.99271053
70glucocorticoid receptor signaling pathway (GO:0042921)2.98747138
71COPI coating of Golgi vesicle (GO:0048205)2.97817176
72Golgi transport vesicle coating (GO:0048200)2.97817176
73branching involved in mammary gland duct morphogenesis (GO:0060444)2.97757455
74negative regulation of mRNA metabolic process (GO:1903312)2.97639961
75DNA duplex unwinding (GO:0032508)2.97624311
76polarized epithelial cell differentiation (GO:0030859)2.96627007
77peptidyl-arginine N-methylation (GO:0035246)2.96484306
78peptidyl-arginine methylation (GO:0018216)2.96484306
79regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.96313605
80urea cycle (GO:0000050)2.95638758
81cell adhesion mediated by integrin (GO:0033627)2.95271768
82IMP biosynthetic process (GO:0006188)2.95267133
83regulation of hippo signaling (GO:0035330)2.95060034
84nuclear envelope organization (GO:0006998)2.94206440
85mitotic sister chromatid cohesion (GO:0007064)2.93713283
86glucose catabolic process (GO:0006007)2.93490865
87DNA geometric change (GO:0032392)2.92638584
88basement membrane organization (GO:0071711)2.92246814
89gap junction assembly (GO:0016264)2.88950913
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88436300
91formation of translation preinitiation complex (GO:0001731)2.87690439
92homocysteine metabolic process (GO:0050667)2.86560832
93positive regulation of epidermal cell differentiation (GO:0045606)2.85921393
94glucose 6-phosphate metabolic process (GO:0051156)2.84122441
95negative regulation of RNA splicing (GO:0033119)2.83517413
96gene silencing (GO:0016458)2.83306772
97G1 DNA damage checkpoint (GO:0044783)2.83148043
98establishment of monopolar cell polarity (GO:0061162)2.82766240
99establishment or maintenance of monopolar cell polarity (GO:0061339)2.82766240
100regulation of water loss via skin (GO:0033561)2.82348633
101negative regulation of mRNA processing (GO:0050686)2.82335982
102positive regulation of epidermis development (GO:0045684)2.81024834
103mitotic G1/S transition checkpoint (GO:0044819)2.79884853
104regulation of histone H3-K9 methylation (GO:0051570)2.79714338
105positive regulation of chromosome segregation (GO:0051984)2.79246515
106regulation of nuclease activity (GO:0032069)2.76959156
107protein export from nucleus (GO:0006611)2.76433973
108positive regulation of SMAD protein import into nucleus (GO:0060391)2.75036061
109protein localization to microtubule (GO:0035372)2.74418656
110intracellular estrogen receptor signaling pathway (GO:0030520)2.70852119
111semaphorin-plexin signaling pathway (GO:0071526)2.70013732
112positive regulation of hair follicle development (GO:0051798)2.69199678
113positive regulation of hair cycle (GO:0042635)2.69199678
114regulation of chromatin binding (GO:0035561)2.68166966
115epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67923362
116germ cell migration (GO:0008354)2.67612863
117NADPH regeneration (GO:0006740)2.67096901
118sex determination (GO:0007530)2.66965543
119regulation of hair follicle development (GO:0051797)2.66560221
120regulation of sister chromatid cohesion (GO:0007063)2.66207450
121folic acid metabolic process (GO:0046655)2.64963713
122apoptotic process involved in morphogenesis (GO:0060561)2.64866808
123regulation of nucleobase-containing compound transport (GO:0032239)2.64835240
124corticosteroid receptor signaling pathway (GO:0031958)2.64351789
125mitotic nuclear envelope reassembly (GO:0007084)2.64209322
126nuclear envelope reassembly (GO:0031468)2.64209322
127endoplasmic reticulum unfolded protein response (GO:0030968)2.63769531
128trophectodermal cell differentiation (GO:0001829)2.62733763
129ER-nucleus signaling pathway (GO:0006984)2.61013103
130midgut development (GO:0007494)2.60767586
131regulation of SMAD protein import into nucleus (GO:0060390)2.60481026
132cytoplasmic mRNA processing body assembly (GO:0033962)2.59878850
133maternal placenta development (GO:0001893)2.58966597
134histone H4-K8 acetylation (GO:0043982)2.58675726
135histone H4-K5 acetylation (GO:0043981)2.58675726
136positive regulation of histone deacetylation (GO:0031065)2.58672271
137nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.58069728
138spindle assembly involved in mitosis (GO:0090307)2.57529521
139mammary gland epithelial cell proliferation (GO:0033598)2.57061933
140positive regulation of RNA splicing (GO:0033120)2.56326884
141negative regulation of cell size (GO:0045792)2.56191536
142regulation of NFAT protein import into nucleus (GO:0051532)2.56083147
143regulation of histone H3-K27 methylation (GO:0061085)2.55023833
144tRNA methylation (GO:0030488)2.54533294
145regulation of glucocorticoid metabolic process (GO:0031943)2.52204895
146male sex determination (GO:0030238)2.51994885
147urea metabolic process (GO:0019627)2.51327761
148cellular response to unfolded protein (GO:0034620)2.50931124
149histone arginine methylation (GO:0034969)2.50462780
150regulation of glucose import in response to insulin stimulus (GO:2001273)2.50297895
151positive regulation of DNA-dependent DNA replication (GO:2000105)2.49694884
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.48885072
153hippo signaling (GO:0035329)2.48745047
154regulation of cholesterol biosynthetic process (GO:0045540)2.46786594
155DNA replication initiation (GO:0006270)2.46313792
156microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.46168076
157mRNA transport (GO:0051028)2.45190111
158intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.44480242
159labyrinthine layer blood vessel development (GO:0060716)2.42195285
160embryonic foregut morphogenesis (GO:0048617)2.42089421
161adherens junction assembly (GO:0034333)2.42052615
162regulation of mRNA stability (GO:0043488)2.41769475
163anatomical structure regression (GO:0060033)2.41647058
164positive regulation of male gonad development (GO:2000020)2.40827125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.67631630
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.50059898
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.79242095
4MYC_22102868_ChIP-Seq_BL_Human3.49166612
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27564155
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.85958370
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84136005
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76815532
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49592144
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34959806
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.22684742
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16717370
13TCF7_22412390_ChIP-Seq_EML_Mouse1.97716954
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94690003
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94415991
16* KDM2B_26808549_Chip-Seq_DND41_Human1.94204266
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94195141
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87701372
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87272164
20VDR_21846776_ChIP-Seq_THP-1_Human1.86987193
21* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86015351
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84410847
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.83445157
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.79896637
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.79896637
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.79896637
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.78507622
28* ESR2_21235772_ChIP-Seq_MCF-7_Human1.74344776
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73564934
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72337028
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72333082
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70791938
33* ZNF263_19887448_ChIP-Seq_K562_Human1.70573560
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.70509015
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69662373
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.67449599
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65591176
38* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64004989
39* ATF3_27146783_Chip-Seq_COLON_Human1.63258128
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62397442
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61030519
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58896359
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58460345
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.57955111
45AR_21909140_ChIP-Seq_LNCAP_Human1.56900219
46XRN2_22483619_ChIP-Seq_HELA_Human1.56060752
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54810467
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54752121
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54343959
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52626853
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48713858
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47020783
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45930146
54* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45571140
55* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45461047
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45165354
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44861941
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44064928
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43630938
60* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43153318
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.42485385
62KDM5A_27292631_Chip-Seq_BREAST_Human1.39935202
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38977373
64CIITA_25753668_ChIP-Seq_RAJI_Human1.37127400
65CLOCK_20551151_ChIP-Seq_293T_Human1.36585259
66NCOR1_26117541_ChIP-Seq_K562_Human1.36138324
67CHD1_26751641_Chip-Seq_LNCaP_Human1.35036949
68* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34413524
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.33910233
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31965027
71* RACK7_27058665_Chip-Seq_MCF-7_Human1.31876656
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31113392
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30519930
74* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30514335
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30513974
76* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30044907
77* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30044907
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27755122
79* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27673780
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27129016
81KDM2B_26808549_Chip-Seq_K562_Human1.26263256
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.25561330
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24675417
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.24447069
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24361392
86* UTX_26944678_Chip-Seq_JUKART_Human1.23880725
87* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23441258
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.22709376
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21562325
90* DCP1A_22483619_ChIP-Seq_HELA_Human1.20666720
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20094834
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15801943
93TFEB_21752829_ChIP-Seq_HELA_Human1.15657573
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14834050
95* RUNX1_27514584_Chip-Seq_MCF-7_Human1.14174225
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14076280
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13705367
98* MAF_26560356_Chip-Seq_TH1_Human1.13676347
99TP53_22127205_ChIP-Seq_IMR90_Human1.13471740
100LXR_22292898_ChIP-Seq_THP-1_Human1.12860842
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11411170
102* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10855108
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10739428
104TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10371584
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.10334905
106* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09631549
107* CREB1_26743006_Chip-Seq_LNCaP_Human1.09412151
108SMC4_20622854_ChIP-Seq_HELA_Human1.09182805
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08374596
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07597081
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06568586
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06557716
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05728338
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04414170
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04299399
116TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03080249
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02799671
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02349726
119P68_20966046_ChIP-Seq_HELA_Human1.00882580
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00440827
121POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00401010
122TP63_19390658_ChIP-ChIP_HaCaT_Human1.00295788
123TTF2_22483619_ChIP-Seq_HELA_Human1.00045652
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99486925
125* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98304742
126* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97001798
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96260262
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96013661
129* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95419114
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91534407
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90954199
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90220585
133* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90118572
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89987678
135UBF1/2_26484160_Chip-Seq_HMECs_Human0.89811011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.47789943
2MP0005076_abnormal_cell_differentiation3.32857419
3MP0010352_gastrointestinal_tract_polyps3.26610181
4MP0003705_abnormal_hypodermis_morpholog3.10771124
5MP0002796_impaired_skin_barrier2.61784714
6MP0005623_abnormal_meninges_morphology2.55303158
7MP0003111_abnormal_nucleus_morphology2.53927113
8MP0004957_abnormal_blastocyst_morpholog2.49471894
9MP0003453_abnormal_keratinocyte_physiol2.46403611
10MP0005501_abnormal_skin_physiology2.35884069
11MP0003300_gastrointestinal_ulcer2.27758568
12MP0005451_abnormal_body_composition2.24896161
13MP0003941_abnormal_skin_development2.24538740
14MP0002877_abnormal_melanocyte_morpholog2.23520876
15MP0002060_abnormal_skin_morphology2.21789610
16MP0001730_embryonic_growth_arrest2.14990090
17MP0010307_abnormal_tumor_latency2.14877692
18MP0003077_abnormal_cell_cycle2.04004939
19MP0008057_abnormal_DNA_replication2.03786398
20MP0010094_abnormal_chromosome_stability2.02517382
21MP0004197_abnormal_fetal_growth/weight/1.98036764
22MP0008877_abnormal_DNA_methylation1.94476601
23MP0003693_abnormal_embryo_hatching1.93476690
24MP0000350_abnormal_cell_proliferation1.92366819
25MP0009278_abnormal_bone_marrow1.91662921
26MP0000467_abnormal_esophagus_morphology1.90186056
27MP0002084_abnormal_developmental_patter1.88760530
28MP0000566_synostosis1.88182267
29MP0003283_abnormal_digestive_organ1.87287028
30MP0000762_abnormal_tongue_morphology1.86931301
31MP0008995_early_reproductive_senescence1.85709772
32MP0003123_paternal_imprinting1.82619257
33MP0002098_abnormal_vibrissa_morphology1.80309791
34MP0001216_abnormal_epidermal_layer1.78495303
35MP0003566_abnormal_cell_adhesion1.77989289
36MP0005409_darkened_coat_color1.77530289
37MP0005257_abnormal_intraocular_pressure1.75832070
38MP0000733_abnormal_muscle_development1.73774968
39MP0004381_abnormal_hair_follicle1.71333940
40MP0005380_embryogenesis_phenotype1.69926427
41MP0001672_abnormal_embryogenesis/_devel1.69926427
42MP0002086_abnormal_extraembryonic_tissu1.69053653
43MP0002085_abnormal_embryonic_tissue1.65163258
44MP0003984_embryonic_growth_retardation1.64731624
45MP0002088_abnormal_embryonic_growth/wei1.62363491
46MP0001697_abnormal_embryo_size1.62061604
47MP0006054_spinal_hemorrhage1.61575068
48MP0010678_abnormal_skin_adnexa1.60019361
49MP0000537_abnormal_urethra_morphology1.55316638
50MP0004808_abnormal_hematopoietic_stem1.53514465
51MP0008260_abnormal_autophagy1.53050850
52MP0002697_abnormal_eye_size1.50460701
53MP0005083_abnormal_biliary_tract1.48578469
54MP0002080_prenatal_lethality1.48336606
55MP0010234_abnormal_vibrissa_follicle1.48092661
56MP0003303_peritoneal_inflammation1.46497431
57MP0004233_abnormal_muscle_weight1.42500170
58MP0008438_abnormal_cutaneous_collagen1.40510793
59MP0003119_abnormal_digestive_system1.37793365
60MP0008007_abnormal_cellular_replicative1.37573401
61MP0004272_abnormal_basement_membrane1.36999421
62MP0000377_abnormal_hair_follicle1.36371864
63MP0010771_integument_phenotype1.36079231
64MP0003786_premature_aging1.32448464
65MP0003091_abnormal_cell_migration1.32171517
66MP0008961_abnormal_basal_metabolism1.29487420
67MP0001915_intracranial_hemorrhage1.29057589
68MP0005058_abnormal_lysosome_morphology1.28506039
69MP0000383_abnormal_hair_follicle1.25131977
70MP0000428_abnormal_craniofacial_morphol1.24945595
71MP0001849_ear_inflammation1.22870723
72MP0002653_abnormal_ependyma_morphology1.22492150
73MP0002396_abnormal_hematopoietic_system1.21605153
74MP0000678_abnormal_parathyroid_gland1.20470940
75MP0003121_genomic_imprinting1.19175096
76MP0003115_abnormal_respiratory_system1.18215668
77MP0003890_abnormal_embryonic-extraembry1.18072635
78MP0001348_abnormal_lacrimal_gland1.15437993
79MP0009931_abnormal_skin_appearance1.13312330
80MP0002925_abnormal_cardiovascular_devel1.12097072
81MP0008932_abnormal_embryonic_tissue1.10029323
82MP0005023_abnormal_wound_healing1.07036047
83MP0009780_abnormal_chondrocyte_physiolo1.04893277
84MP0004782_abnormal_surfactant_physiolog1.04294733
85MP0009703_decreased_birth_body1.04092240
86MP0000490_abnormal_crypts_of1.03948063
87MP0000627_abnormal_mammary_gland1.02621271
88MP0002092_abnormal_eye_morphology1.01528327
89MP0010030_abnormal_orbit_morphology0.99736870
90MP0003567_abnormal_fetal_cardiomyocyte0.98775299
91MP0001661_extended_life_span0.98655489
92MP0000858_altered_metastatic_potential0.98297375
93MP0000003_abnormal_adipose_tissue0.98259734
94MP0000313_abnormal_cell_death0.97684118
95MP0005375_adipose_tissue_phenotype0.97234798
96MP0009840_abnormal_foam_cell0.96551023
97MP0009672_abnormal_birth_weight0.96353015
98MP0001545_abnormal_hematopoietic_system0.95272866
99MP0005397_hematopoietic_system_phenotyp0.95272866
100MP0003878_abnormal_ear_physiology0.93725855
101MP0005377_hearing/vestibular/ear_phenot0.93725855
102MP0008770_decreased_survivor_rate0.92678634
103MP0005621_abnormal_cell_physiology0.91865481
104MP0004264_abnormal_extraembryonic_tissu0.90647109
105MP0002089_abnormal_postnatal_growth/wei0.90116272
106MP0003935_abnormal_craniofacial_develop0.90093850
107MP0001145_abnormal_male_reproductive0.89324589
108MP0003942_abnormal_urinary_system0.88775817
109MP0004185_abnormal_adipocyte_glucose0.88529008
110MP0003045_fibrosis0.88004536
111MP0002210_abnormal_sex_determination0.87195003
112MP0009053_abnormal_anal_canal0.86262701
113MP0000013_abnormal_adipose_tissue0.85791331
114MP0002896_abnormal_bone_mineralization0.84887598
115MP0003861_abnormal_nervous_system0.84869404
116MP0002019_abnormal_tumor_incidence0.84652061
117MP0000462_abnormal_digestive_system0.84435208
118MP0000534_abnormal_ureter_morphology0.83671102
119MP0000432_abnormal_head_morphology0.83156317
120MP0004947_skin_inflammation0.82032021
121MP0000703_abnormal_thymus_morphology0.81988767
122MP0001784_abnormal_fluid_regulation0.81180899
123MP0001293_anophthalmia0.80213367
124MP0003279_aneurysm0.79435179
125MP0005384_cellular_phenotype0.77316017
126MP0002111_abnormal_tail_morphology0.76654686
127MP0005197_abnormal_uvea_morphology0.75583265
128MP0001340_abnormal_eyelid_morphology0.75227099
129MP0004858_abnormal_nervous_system0.73749470
130MP0000266_abnormal_heart_morphology0.73068244
131MP0005666_abnormal_adipose_tissue0.72568105
132MP0002116_abnormal_craniofacial_bone0.71197121
133MP0001243_abnormal_dermal_layer0.69957883
134MP0003936_abnormal_reproductive_system0.69911811
135MP0010630_abnormal_cardiac_muscle0.68407157
136MP0005187_abnormal_penis_morphology0.68112983
137MP0000367_abnormal_coat/_hair0.67647039
138MP0001286_abnormal_eye_development0.67263672
139MP0003315_abnormal_perineum_morphology0.67118361
140MP0002254_reproductive_system_inflammat0.65528230
141MP0000358_abnormal_cell_content/0.64845413
142MP0001881_abnormal_mammary_gland0.64607985
143MP0003191_abnormal_cellular_cholesterol0.63494514

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)4.31052998
2Fragile nails (HP:0001808)3.87284046
3Atrophic scars (HP:0001075)3.70520924
4Hand muscle atrophy (HP:0009130)3.50174793
5Onycholysis (HP:0001806)3.48381754
6Distal upper limb amyotrophy (HP:0007149)3.34093868
7Upper limb amyotrophy (HP:0009129)3.34093868
8Pterygium (HP:0001059)3.26352736
9Plantar hyperkeratosis (HP:0007556)3.26142302
10Abnormality of nail color (HP:0100643)3.21921806
11Protrusio acetabuli (HP:0003179)3.12213233
12Nail dystrophy (HP:0008404)3.10338691
13Broad face (HP:0000283)3.09250492
14Thick nail (HP:0001805)2.96366629
15Ependymoma (HP:0002888)2.93285947
16Fragile skin (HP:0001030)2.93180858
17Pili torti (HP:0003777)2.91858327
18Hyperacusis (HP:0010780)2.90271885
19Natal tooth (HP:0000695)2.82964054
20Astrocytoma (HP:0009592)2.72738231
21Abnormality of the astrocytes (HP:0100707)2.72738231
22Cerebral aneurysm (HP:0004944)2.72053796
23Ankle contracture (HP:0006466)2.71063339
24Selective tooth agenesis (HP:0001592)2.67068605
25Right ventricular cardiomyopathy (HP:0011663)2.65302640
26Missing ribs (HP:0000921)2.64286455
27Aplasia cutis congenita (HP:0001057)2.63924614
28Advanced eruption of teeth (HP:0006288)2.62432952
29Long palpebral fissure (HP:0000637)2.60361984
30Deviation of the thumb (HP:0009603)2.55867887
31Ridged nail (HP:0001807)2.53410953
32Abnormality of the calcaneus (HP:0008364)2.53161342
33Proximal placement of thumb (HP:0009623)2.50560164
34Male infertility (HP:0003251)2.49976912
35Vertebral compression fractures (HP:0002953)2.47882024
36Alopecia of scalp (HP:0002293)2.46538427
37Elbow flexion contracture (HP:0002987)2.41575181
38Heterotopia (HP:0002282)2.39461573
39Genu recurvatum (HP:0002816)2.37612743
40Shallow orbits (HP:0000586)2.36831230
41Short nail (HP:0001799)2.36778979
42Progressive muscle weakness (HP:0003323)2.35819926
43Asymmetry of the thorax (HP:0001555)2.35225211
44Flat acetabular roof (HP:0003180)2.34910352
45Premature rupture of membranes (HP:0001788)2.33725904
46Bowel diverticulosis (HP:0005222)2.29917077
47Bladder diverticulum (HP:0000015)2.29182462
48Insomnia (HP:0100785)2.28681365
49Septate vagina (HP:0001153)2.28515485
50Abnormal hair laboratory examination (HP:0003328)2.27064885
51Renal duplication (HP:0000075)2.23508430
52Increased density of long bones (HP:0006392)2.23300610
53Abnormality of the lower motor neuron (HP:0002366)2.23133100
54Abnormality of the distal phalanges of the toes (HP:0010182)2.20727475
55Abnormality of the salivary glands (HP:0010286)2.18516302
56Rectal prolapse (HP:0002035)2.17386231
57Increased nuchal translucency (HP:0010880)2.17162210
58Sparse eyelashes (HP:0000653)2.16257874
59Distal lower limb amyotrophy (HP:0008944)2.15840482
60Abnormality of the Achilles tendon (HP:0005109)2.15196739
61Sparse lateral eyebrow (HP:0005338)2.10214337
62Hypotrichosis (HP:0001006)2.09078440
63Hypoplasia of dental enamel (HP:0006297)2.08636748
64Palmoplantar hyperkeratosis (HP:0000972)2.08594080
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05852166
66Short 4th metacarpal (HP:0010044)2.05852166
67Distal lower limb muscle weakness (HP:0009053)2.05351336
68Reticulocytosis (HP:0001923)2.03625902
69Macroorchidism (HP:0000053)2.00725696
70Abnormal blistering of the skin (HP:0008066)1.99414079
71Difficulty climbing stairs (HP:0003551)1.99010717
72Metaphyseal cupping (HP:0003021)1.96920682
7311 pairs of ribs (HP:0000878)1.96535322
74Glioma (HP:0009733)1.96534449
75Renovascular hypertension (HP:0100817)1.92874017
76Basal cell carcinoma (HP:0002671)1.92221185
77Subacute progressive viral hepatitis (HP:0006572)1.91665541
78Pseudobulbar signs (HP:0002200)1.91569943
79Palmar hyperkeratosis (HP:0010765)1.91291158
80Osteolytic defects of the hand bones (HP:0009699)1.91208789
81Osteolytic defects of the phalanges of the hand (HP:0009771)1.91208789
82Micronodular cirrhosis (HP:0001413)1.90775394
83Nasolacrimal duct obstruction (HP:0000579)1.90340549
84Thin ribs (HP:0000883)1.89330739
85Neoplasm of the oral cavity (HP:0100649)1.88686554
86Elfin facies (HP:0004428)1.86859930
87Trismus (HP:0000211)1.86276149
88Testicular neoplasm (HP:0010788)1.86159979
89Breast hypoplasia (HP:0003187)1.85589070
90Short humerus (HP:0005792)1.84198822
91Facial hemangioma (HP:0000329)1.83978070
92Broad palm (HP:0001169)1.83504983
93Ulnar deviation of the wrist (HP:0003049)1.82400552
94Gastrointestinal carcinoma (HP:0002672)1.82349992
95Malignant gastrointestinal tract tumors (HP:0006749)1.82349992
96Pointed chin (HP:0000307)1.82310888
97Urethral obstruction (HP:0000796)1.80648446
98Squamous cell carcinoma (HP:0002860)1.80275753
99Increased connective tissue (HP:0009025)1.79108010
100Congenital hip dislocation (HP:0001374)1.78420952
101Overriding aorta (HP:0002623)1.77772818
102Rib fusion (HP:0000902)1.76961154
103Mitral valve prolapse (HP:0001634)1.76702300
104Poikiloderma (HP:0001029)1.75852576
105Prominent nose (HP:0000448)1.75715247
106Ankyloglossia (HP:0010296)1.74794847
107Lip pit (HP:0100267)1.74001788
108Nuclear cataract (HP:0100018)1.73079053
109Medulloblastoma (HP:0002885)1.72920457
110Cervical subluxation (HP:0003308)1.72329408
111Pelvic girdle muscle weakness (HP:0003749)1.71419024
112Dysmetric saccades (HP:0000641)1.70962099
113Calcaneovalgus deformity (HP:0001848)1.69872971
114Abnormality of oral frenula (HP:0000190)1.69858725
115Aplasia/hypoplasia of the humerus (HP:0006507)1.69675425
116Spinal muscular atrophy (HP:0007269)1.68017877
117Dilatation of the ascending aorta (HP:0005111)1.67956353
118Colon cancer (HP:0003003)1.67791003
119Aneurysm (HP:0002617)1.67073550
120Abnormality of the gastric mucosa (HP:0004295)1.67000723
121Termporal pattern (HP:0011008)1.66914330
122Insidious onset (HP:0003587)1.66914330
123Enlarged penis (HP:0000040)1.66096670
124Back pain (HP:0003418)1.65867618
125Abnormality of the umbilical cord (HP:0010881)1.65775528
126Overlapping toe (HP:0001845)1.64985670
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64599525
128Hallux valgus (HP:0001822)1.64301315
129Broad thumb (HP:0011304)1.63997331
130Neoplasm of the heart (HP:0100544)1.63985473
131Abnormality of the peritoneum (HP:0002585)1.63357185
132Ulnar bowing (HP:0003031)1.62379237
133Fibroma (HP:0010614)1.62188566
134Abnormality of the anterior horn cell (HP:0006802)1.62062043
135Degeneration of anterior horn cells (HP:0002398)1.62062043
136Volvulus (HP:0002580)1.61751912
137Skull defect (HP:0001362)1.61599614
138Mildly elevated creatine phosphokinase (HP:0008180)1.61467735
139Thin bony cortex (HP:0002753)1.61457463
140Disproportionate tall stature (HP:0001519)1.60974436
141Aortic aneurysm (HP:0004942)1.60727012
142Abnormalities of placenta or umbilical cord (HP:0001194)1.60693438
143Ragged-red muscle fibers (HP:0003200)1.60571552
144Vertebral hypoplasia (HP:0008417)1.60113538
145Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.60113538
146High pitched voice (HP:0001620)1.59571187
147Deviation of the hallux (HP:0010051)1.59147354
148Arnold-Chiari malformation (HP:0002308)1.58519782
149Abnormality of the musculature of the hand (HP:0001421)1.58112948
150Round ear (HP:0100830)1.57912615
151Neoplasm of striated muscle (HP:0009728)1.57701349
152Vertebral fusion (HP:0002948)1.57068569
153Unilateral renal agenesis (HP:0000122)1.56449790
154Vertebral arch anomaly (HP:0008438)1.56092751
155Fibrous tissue neoplasm (HP:0012316)1.55769144
156Muscle fibrillation (HP:0010546)1.55753658
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.55717655
158Bowing of the arm (HP:0006488)1.55497550
159Bowed forearm bones (HP:0003956)1.55497550
160Achilles tendon contracture (HP:0001771)1.55248095
161Hypopigmentation of the fundus (HP:0007894)1.55115998
162Hyperparathyroidism (HP:0000843)1.55109736
163Cerebral inclusion bodies (HP:0100314)1.54074929
164Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.53952134
165Megalocornea (HP:0000485)1.53760976
166Abnormality of the lacrimal duct (HP:0011481)1.53127589
167Biconcave vertebral bodies (HP:0004586)1.53069973
168Ureteral duplication (HP:0000073)1.52931471
169Germ cell neoplasia (HP:0100728)1.52472205
170Patellar dislocation (HP:0002999)1.51571456
171Breech presentation (HP:0001623)1.51308679
172Trigonocephaly (HP:0000243)1.50503503
173Somatic mutation (HP:0001428)1.50093852
174Skin tags (HP:0010609)1.49278798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.97980347
2CDK124.63765058
3MST1R4.45692577
4TRIB34.05078972
5SMG13.52347265
6PKN23.21184627
7IRAK33.08389939
8NME22.56403031
9CDC72.48727498
10MAP3K102.39253839
11ICK2.27794677
12PRPF4B2.12193074
13SCYL22.11924391
14PDK22.06202214
15PDGFRA1.90513847
16ALK1.87252028
17NEK21.82782302
18TYRO31.80189882
19EPHA21.76358419
20PASK1.74339214
21RPS6KB21.66515516
22MTOR1.66393369
23BMX1.65127014
24PTK61.64321461
25RIPK11.58440036
26BRD41.57529726
27LATS11.49092864
28ERN11.45941769
29PRKD31.45507945
30MAP3K91.45384387
31PAK21.44422475
32LMTK21.42881446
33CDK71.34660334
34ARAF1.30690703
35PAK41.27257560
36PBK1.23986415
37CDK41.22990558
38LATS21.22226345
39TSSK61.21340367
40TAOK11.20914342
41NTRK11.20630380
42CDK61.19326015
43LRRK21.18743050
44STK101.17433564
45FGFR41.15331215
46TTN1.12550416
47NEK11.12253366
48TAOK21.10408024
49MAP3K81.08721369
50EIF2AK11.07084262
51DDR21.06906842
52BUB11.06213563
53WEE11.05536225
54CHEK11.05055264
55TTK1.03388582
56PTK20.97730228
57SIK10.93846665
58PDGFRB0.83563814
59CAMK1G0.83127419
60PNCK0.82410515
61ERBB40.81245013
62STK30.80484700
63NEK60.79059897
64MAPKAPK30.79011518
65CDK20.75854208
66MAPK110.74797202
67ATR0.72144138
68PIM10.69996882
69FGFR10.69467213
70CDK80.69455058
71RET0.69008532
72BRAF0.68599413
73PLK10.67283575
74BRSK10.66730612
75CAMK1D0.66205898
76IRAK20.64240915
77CDK90.63994095
78ATM0.63662970
79MAP3K30.63639307
80AURKB0.62626879
81CHUK0.61440886
82TESK20.60739969
83AKT20.60495523
84TGFBR10.60424509
85RPS6KA40.59086393
86CHEK20.58035398
87FLT30.56521632
88MAP4K10.56440687
89MAP3K130.54070672
90DMPK0.54008496
91TESK10.52337863
92MET0.51477820
93SIK30.51295347
94CDK10.50778280
95RPS6KA10.49147506
96MAP2K20.48320095
97JAK30.48237963
98VRK20.47964453
99RPS6KA20.47787217
100PRKDC0.47430026
101PDPK10.47318381
102CSNK1D0.47216724
103CSNK1E0.47008267
104ZAP700.46794338
105MAP3K10.46210821
106PIM20.45621452
107MAPK140.45502137
108PAK10.43578472
109MAPK10.42434449
110AURKA0.42412245
111KDR0.42356251
112DYRK1B0.41845574
113MAP2K30.41710768
114RAF10.41016829
115ILK0.40860555
116EPHB10.40797539
117PRKCI0.40541476
118HIPK20.40306902
119SRPK10.40017754
120KSR20.39511293
121CDC42BPA0.38515467
122MAP3K20.37978742
123AKT10.37863767
124SIK20.37144914
125EGFR0.36973680
126PLK30.36708946
127RPS6KL10.35317839
128RPS6KC10.35317839
129GSK3B0.35089830
130MAP3K110.34875076
131RPS6KB10.34232878
132MELK0.33861826
133MAPKAPK20.33729815
134PAK60.33594867
135GSK3A0.32890580
136PRKG20.32367523
137MAP2K10.32029215
138CLK10.31492610
139MUSK0.31261481

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.39346269
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35051802
3Biosynthesis of amino acids_Homo sapiens_hsa012302.30350574
4RNA transport_Homo sapiens_hsa030132.25926757
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99941432
6Pentose phosphate pathway_Homo sapiens_hsa000301.97469600
7mRNA surveillance pathway_Homo sapiens_hsa030151.95558147
8Chronic myeloid leukemia_Homo sapiens_hsa052201.83048531
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81986748
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75792650
11Cell cycle_Homo sapiens_hsa041101.74435851
12Spliceosome_Homo sapiens_hsa030401.67884079
13DNA replication_Homo sapiens_hsa030301.67293341
14Small cell lung cancer_Homo sapiens_hsa052221.62349738
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61927181
16Vitamin B6 metabolism_Homo sapiens_hsa007501.59624055
17mTOR signaling pathway_Homo sapiens_hsa041501.58195303
18MicroRNAs in cancer_Homo sapiens_hsa052061.55290275
19Fructose and mannose metabolism_Homo sapiens_hsa000511.50433074
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49649600
21Adherens junction_Homo sapiens_hsa045201.46969074
22Galactose metabolism_Homo sapiens_hsa000521.46873266
23Notch signaling pathway_Homo sapiens_hsa043301.39625130
24Hippo signaling pathway_Homo sapiens_hsa043901.37782562
25Bladder cancer_Homo sapiens_hsa052191.36147215
26Viral carcinogenesis_Homo sapiens_hsa052031.35380886
27Colorectal cancer_Homo sapiens_hsa052101.31186287
28Focal adhesion_Homo sapiens_hsa045101.30860071
29Mismatch repair_Homo sapiens_hsa034301.30115133
30HTLV-I infection_Homo sapiens_hsa051661.29825076
31Prion diseases_Homo sapiens_hsa050201.29570743
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29037493
33Proteoglycans in cancer_Homo sapiens_hsa052051.28310157
34Endometrial cancer_Homo sapiens_hsa052131.22170712
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20325549
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18949550
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18581047
38Carbon metabolism_Homo sapiens_hsa012001.18476226
39TGF-beta signaling pathway_Homo sapiens_hsa043501.17942908
40p53 signaling pathway_Homo sapiens_hsa041151.16863300
41Arginine biosynthesis_Homo sapiens_hsa002201.15746861
42Acute myeloid leukemia_Homo sapiens_hsa052211.15337691
43Glioma_Homo sapiens_hsa052141.14892060
44Dorso-ventral axis formation_Homo sapiens_hsa043201.14083667
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12563048
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12043001
47Prostate cancer_Homo sapiens_hsa052151.11855270
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.11687980
49Pancreatic cancer_Homo sapiens_hsa052121.09110880
50Basal cell carcinoma_Homo sapiens_hsa052171.08769729
51ECM-receptor interaction_Homo sapiens_hsa045121.07624272
52Thyroid cancer_Homo sapiens_hsa052161.07307995
53* Central carbon metabolism in cancer_Homo sapiens_hsa052301.05592837
54VEGF signaling pathway_Homo sapiens_hsa043701.05199948
55Other glycan degradation_Homo sapiens_hsa005111.03860206
56Estrogen signaling pathway_Homo sapiens_hsa049151.03834644
57Non-small cell lung cancer_Homo sapiens_hsa052231.03537408
58Viral myocarditis_Homo sapiens_hsa054161.02724913
59Oocyte meiosis_Homo sapiens_hsa041141.01658912
60Renal cell carcinoma_Homo sapiens_hsa052111.00517257
61Hedgehog signaling pathway_Homo sapiens_hsa043400.99722919
62Sulfur relay system_Homo sapiens_hsa041220.96536296
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.95453723
64Base excision repair_Homo sapiens_hsa034100.94697265
65Nucleotide excision repair_Homo sapiens_hsa034200.93584748
66Prolactin signaling pathway_Homo sapiens_hsa049170.93242312
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92851921
68HIF-1 signaling pathway_Homo sapiens_hsa040660.92231977
69Tight junction_Homo sapiens_hsa045300.91578303
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89460411
71Amoebiasis_Homo sapiens_hsa051460.87937503
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87161324
73Antigen processing and presentation_Homo sapiens_hsa046120.86761751
74N-Glycan biosynthesis_Homo sapiens_hsa005100.85515006
75Pathways in cancer_Homo sapiens_hsa052000.84928958
76Hepatitis B_Homo sapiens_hsa051610.84629566
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83959928
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82070335
79Apoptosis_Homo sapiens_hsa042100.81979041
80Toxoplasmosis_Homo sapiens_hsa051450.80608248
81Wnt signaling pathway_Homo sapiens_hsa043100.80295023
82Epstein-Barr virus infection_Homo sapiens_hsa051690.79056868
83Lysine degradation_Homo sapiens_hsa003100.78966387
84Steroid biosynthesis_Homo sapiens_hsa001000.77012807
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75443425
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.75410840
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75403165
88RNA degradation_Homo sapiens_hsa030180.74553661
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74372537
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74076387
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73593351
92ErbB signaling pathway_Homo sapiens_hsa040120.72318531
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71862825
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71459597
95Pyrimidine metabolism_Homo sapiens_hsa002400.71256373
96Protein digestion and absorption_Homo sapiens_hsa049740.70502560
97AMPK signaling pathway_Homo sapiens_hsa041520.70460422
98Hepatitis C_Homo sapiens_hsa051600.67979056
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.67670833
100Insulin resistance_Homo sapiens_hsa049310.67317358
101Inositol phosphate metabolism_Homo sapiens_hsa005620.66964604
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66857573
103Non-homologous end-joining_Homo sapiens_hsa034500.66120898
104T cell receptor signaling pathway_Homo sapiens_hsa046600.64030464
105Melanoma_Homo sapiens_hsa052180.62181975
106Herpes simplex infection_Homo sapiens_hsa051680.61279774
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60830164
108Rap1 signaling pathway_Homo sapiens_hsa040150.60456529
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.60344884
110Insulin signaling pathway_Homo sapiens_hsa049100.59309842
111Glucagon signaling pathway_Homo sapiens_hsa049220.59035012
112Shigellosis_Homo sapiens_hsa051310.58841261
113FoxO signaling pathway_Homo sapiens_hsa040680.58749390
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56332586
115Selenocompound metabolism_Homo sapiens_hsa004500.56258891
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56139424
117MAPK signaling pathway_Homo sapiens_hsa040100.55310911
118B cell receptor signaling pathway_Homo sapiens_hsa046620.55245620
119Gap junction_Homo sapiens_hsa045400.55202060
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52522350
121Platelet activation_Homo sapiens_hsa046110.52305705
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51947799
123Fanconi anemia pathway_Homo sapiens_hsa034600.51550299
124Endocytosis_Homo sapiens_hsa041440.51400131
125Alcoholism_Homo sapiens_hsa050340.51341648
126Vibrio cholerae infection_Homo sapiens_hsa051100.51242468
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.50187144
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48232783
129Folate biosynthesis_Homo sapiens_hsa007900.47228789
130Ribosome_Homo sapiens_hsa030100.46782156
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46769453

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