SLC7A5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell differentiation (GO:0032825)6.42605321
2regulation of chronic inflammatory response (GO:0002676)5.91682133
3positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.78236851
4positive regulation of natural killer cell mediated immunity (GO:0002717)5.64490534
5DNA deamination (GO:0045006)5.59396459
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.86534092
7regulation of isotype switching to IgG isotypes (GO:0048302)4.80749046
8positive regulation of interleukin-17 production (GO:0032740)4.74667309
9regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.69570169
10regulation of natural killer cell mediated immunity (GO:0002715)4.69570169
11CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.69194130
12cellular response to interleukin-15 (GO:0071350)4.48175410
13regulation of regulatory T cell differentiation (GO:0045589)4.41399685
14Peyers patch development (GO:0048541)4.40372953
15mucosal-associated lymphoid tissue development (GO:0048537)4.40372953
16regulation of natural killer cell differentiation (GO:0032823)4.26319037
17positive regulation of gamma-delta T cell activation (GO:0046645)4.14700100
18response to interleukin-15 (GO:0070672)4.09491016
19regulation of gamma-delta T cell differentiation (GO:0045586)4.00413717
20positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.86963256
21regulation of interleukin-2 biosynthetic process (GO:0045076)3.85824098
22DNA synthesis involved in DNA repair (GO:0000731)3.81702735
23positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.77822357
24positive regulation of interleukin-10 production (GO:0032733)3.76571830
25regulation of leukocyte mediated cytotoxicity (GO:0001910)3.73894059
26positive regulation of B cell differentiation (GO:0045579)3.71275325
27regulation of B cell differentiation (GO:0045577)3.70537819
28cytidine deamination (GO:0009972)3.68094317
29cytidine metabolic process (GO:0046087)3.68094317
30cytidine catabolic process (GO:0006216)3.68094317
31T cell lineage commitment (GO:0002360)3.62711043
32viral mRNA export from host cell nucleus (GO:0046784)3.61163666
33regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.60267977
34negative regulation of T cell mediated immunity (GO:0002710)3.54809323
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54447704
36positive regulation of alpha-beta T cell proliferation (GO:0046641)3.54401244
37negative thymic T cell selection (GO:0045060)3.50060230
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43515292
39positive regulation of natural killer cell activation (GO:0032816)3.43175412
40negative T cell selection (GO:0043383)3.38993210
41positive regulation of cell killing (GO:0031343)3.35693141
42negative regulation of T-helper cell differentiation (GO:0045623)3.34021342
43negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.34021342
44positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.29762112
45regulation of cell killing (GO:0031341)3.29522504
46regulation of gamma-delta T cell activation (GO:0046643)3.23672673
47T cell migration (GO:0072678)3.21611532
48positive thymic T cell selection (GO:0045059)3.21315316
49cytokine production involved in immune response (GO:0002367)3.19769237
50regulation of alpha-beta T cell proliferation (GO:0046640)3.18713390
51thymic T cell selection (GO:0045061)3.18111541
52regulation of B cell proliferation (GO:0030888)3.16812236
53regulation of B cell receptor signaling pathway (GO:0050855)3.16367947
54lymph node development (GO:0048535)3.16318503
55regulation of isotype switching (GO:0045191)3.14293688
56regulation of interleukin-10 production (GO:0032653)3.12738811
57positive regulation of B cell proliferation (GO:0030890)3.12583505
58pyrimidine ribonucleoside catabolic process (GO:0046133)3.10038685
59positive regulation of lymphocyte mediated immunity (GO:0002708)3.08543573
60negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08382564
61negative regulation of cell killing (GO:0031342)3.08382564
62ncRNA 3-end processing (GO:0043628)3.07547121
63negative regulation of adaptive immune response (GO:0002820)3.01354829
64production of molecular mediator of immune response (GO:0002440)3.00450322
65regulation of B cell activation (GO:0050864)3.00401568
66positive regulation of isotype switching (GO:0045830)2.96591200
67positive regulation of granulocyte differentiation (GO:0030854)2.95670267
68positive regulation of lymphocyte differentiation (GO:0045621)2.93790173
69tolerance induction (GO:0002507)2.93204409
70positive T cell selection (GO:0043368)2.91814769
71leukocyte aggregation (GO:0070486)2.90811495
72regulation of interleukin-2 production (GO:0032663)2.90655460
73negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.90613475
74positive regulation of B cell activation (GO:0050871)2.90233311
75negative regulation by host of viral transcription (GO:0043922)2.89655777
76positive regulation of interleukin-2 production (GO:0032743)2.89128936
77negative regulation of acute inflammatory response (GO:0002674)2.87874288
78regulation of lymphocyte mediated immunity (GO:0002706)2.85587647
79histone H4-K8 acetylation (GO:0043982)2.83321087
80histone H4-K5 acetylation (GO:0043981)2.83321087
81negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.83172636
82regulation of natural killer cell activation (GO:0032814)2.83133129
83regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.82312418
84negative regulation of interleukin-2 production (GO:0032703)2.82078285
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81282959
86regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.80716151
87regulation of interleukin-12 biosynthetic process (GO:0045075)2.80542967
88regulation of lymphocyte chemotaxis (GO:1901623)2.80467641
89regulation of interleukin-17 production (GO:0032660)2.78198831
90rRNA transcription (GO:0009303)2.77802066
91regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.76547966
92T cell mediated immunity (GO:0002456)2.75590186
93CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.73760140
94B cell receptor signaling pathway (GO:0050853)2.70727189
95positive regulation of activated T cell proliferation (GO:0042104)2.67299744
96negative regulation of B cell activation (GO:0050869)2.66714188
97positive regulation of chemokine biosynthetic process (GO:0045080)2.65286503
98T cell selection (GO:0045058)2.65179796
99positive regulation of leukocyte mediated immunity (GO:0002705)2.63637814
100T cell differentiation (GO:0030217)2.63239791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.13453084
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.62950820
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.77398197
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.62060986
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.61209149
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.34912430
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22303220
8MYC_22102868_ChIP-Seq_BL_Human3.15840290
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.00999596
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72395840
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.54744620
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48178587
13* MYB_26560356_Chip-Seq_TH2_Human2.41351157
14SCL_19346495_ChIP-Seq_HPC-7_Human2.39956627
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39876885
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30069056
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.25977960
18VDR_23849224_ChIP-Seq_CD4+_Human2.14021557
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07891616
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07219609
21* MAF_26560356_Chip-Seq_TH1_Human2.06631078
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05398028
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99557986
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.97202487
25* MYB_26560356_Chip-Seq_TH1_Human1.96900435
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95303016
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94340759
28VDR_21846776_ChIP-Seq_THP-1_Human1.93596170
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.91263478
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89330742
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.89016052
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88679239
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85123025
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81774517
35* MAF_26560356_Chip-Seq_TH2_Human1.80184606
36FOXP3_21729870_ChIP-Seq_TREG_Human1.79888343
37RUNX_20019798_ChIP-Seq_JUKART_Human1.76049225
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75739783
39GATA1_22025678_ChIP-Seq_K562_Human1.75686222
40CIITA_25753668_ChIP-Seq_RAJI_Human1.73907589
41ZNF263_19887448_ChIP-Seq_K562_Human1.66705704
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66082467
43UTX_26944678_Chip-Seq_JUKART_Human1.65812037
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63368684
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62820494
46DCP1A_22483619_ChIP-Seq_HELA_Human1.58820582
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58641189
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56973338
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54950943
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54052643
51GATA3_27048872_Chip-Seq_THYMUS_Human1.45515842
52* XRN2_22483619_ChIP-Seq_HELA_Human1.43505142
53SPI1_23547873_ChIP-Seq_NB4_Human1.42588266
54KDM5A_27292631_Chip-Seq_BREAST_Human1.40627411
55GABP_19822575_ChIP-Seq_HepG2_Human1.39927336
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39198227
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37926463
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37792696
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.32722013
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28980954
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25979233
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24548030
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.24238036
64IRF1_19129219_ChIP-ChIP_H3396_Human1.22411827
65TFEB_21752829_ChIP-Seq_HELA_Human1.21055237
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20244598
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20241917
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19920576
69TTF2_22483619_ChIP-Seq_HELA_Human1.19791768
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19714095
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18971696
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18481034
73ELK1_19687146_ChIP-ChIP_HELA_Human1.18183698
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.17587120
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14742595
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14664846
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13919806
78* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11377454
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11191845
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10181438
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09587675
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09068823
83GATA3_26560356_Chip-Seq_TH2_Human1.08906824
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.07736749
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07570381
86VDR_24763502_ChIP-Seq_THP-1_Human1.06345631
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05440491
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05035838
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04968235
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03891369
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03255333
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.02967887
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02319965
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01999701
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99913041
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99492582
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98030673
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.97545526
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96871447
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96502917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation4.68250104
2MP0005671_abnormal_response_to4.67177215
3MP0003763_abnormal_thymus_physiology4.12058577
4MP0009333_abnormal_splenocyte_physiolog3.76580689
5MP0001835_abnormal_antigen_presentation2.81785287
6MP0005000_abnormal_immune_tolerance2.69350281
7MP0008057_abnormal_DNA_replication2.60453439
8MP0001800_abnormal_humoral_immune2.52009898
9MP0008058_abnormal_DNA_repair2.40900380
10MP0000465_gastrointestinal_hemorrhage2.40628722
11MP0005387_immune_system_phenotype2.25902737
12MP0001790_abnormal_immune_system2.25902737
13MP0002398_abnormal_bone_marrow2.24491200
14MP0005075_abnormal_melanosome_morpholog2.22795238
15MP0002420_abnormal_adaptive_immunity2.15184572
16MP0001348_abnormal_lacrimal_gland2.14437634
17MP0004381_abnormal_hair_follicle2.13645734
18MP0004145_abnormal_muscle_electrophysio2.12658462
19MP0000685_abnormal_immune_system2.12165898
20MP0006082_CNS_inflammation2.09034830
21MP0003111_abnormal_nucleus_morphology2.04622105
22MP0002723_abnormal_immune_serum2.01063699
23MP0000689_abnormal_spleen_morphology2.00987404
24MP0001819_abnormal_immune_cell2.00034757
25MP0003436_decreased_susceptibility_to1.97839851
26MP0003136_yellow_coat_color1.97463567
27MP0000703_abnormal_thymus_morphology1.96347443
28MP0002722_abnormal_immune_system1.88929827
29MP0002452_abnormal_antigen_presenting1.86142250
30MP0003866_abnormal_defecation1.85517539
31MP0002405_respiratory_system_inflammati1.82348918
32MP0002396_abnormal_hematopoietic_system1.82307756
33MP0000716_abnormal_immune_system1.79870756
34MP0003786_premature_aging1.79762502
35MP0002877_abnormal_melanocyte_morpholog1.76665171
36MP0002148_abnormal_hypersensitivity_rea1.76322237
37MP0005310_abnormal_salivary_gland1.75040997
38MP0010094_abnormal_chromosome_stability1.66913850
39MP0002429_abnormal_blood_cell1.63715068
40MP0004808_abnormal_hematopoietic_stem1.56536963
41MP0004957_abnormal_blastocyst_morpholog1.52688957
42MP0004742_abnormal_vestibular_system1.51446654
43MP0002166_altered_tumor_susceptibility1.49857389
44MP0008995_early_reproductive_senescence1.49232583
45MP0002009_preneoplasia1.46577820
46MP0001853_heart_inflammation1.42443780
47MP0005645_abnormal_hypothalamus_physiol1.38480467
48MP0004147_increased_porphyrin_level1.37751239
49MP0010155_abnormal_intestine_physiology1.36537038
50MP0005025_abnormal_response_to1.33283114
51MP0002019_abnormal_tumor_incidence1.27459681
52MP0000372_irregular_coat_pigmentation1.26688728
53MP0009785_altered_susceptibility_to1.25460897
54MP0002419_abnormal_innate_immunity1.22439607
55MP0003693_abnormal_embryo_hatching1.21611670
56MP0003077_abnormal_cell_cycle1.20016684
57MP0005464_abnormal_platelet_physiology1.19549332
58MP0001845_abnormal_inflammatory_respons1.19322079
59MP0002006_tumorigenesis1.16885188
60MP0010307_abnormal_tumor_latency1.15378047
61MP0008872_abnormal_physiological_respon1.13865333
62MP0002132_abnormal_respiratory_system1.13350226
63MP0001188_hyperpigmentation1.11396934
64MP0005076_abnormal_cell_differentiation1.09402962
65MP0000015_abnormal_ear_pigmentation1.08164711
66MP0002933_joint_inflammation1.06691024
67MP0000490_abnormal_crypts_of1.06285888
68MP0008961_abnormal_basal_metabolism1.01577090
69MP0004947_skin_inflammation1.01031100
70MP0003045_fibrosis1.00940391
71MP0002138_abnormal_hepatobiliary_system0.91863644
72MP0008469_abnormal_protein_level0.88385209
73MP0000313_abnormal_cell_death0.83611089
74MP0000371_diluted_coat_color0.81918780
75MP0005083_abnormal_biliary_tract0.81640954
76MP0009765_abnormal_xenobiotic_induced0.80328886
77MP0008007_abnormal_cellular_replicative0.77793635
78MP0008932_abnormal_embryonic_tissue0.76655330
79MP0000350_abnormal_cell_proliferation0.73355254
80MP0002095_abnormal_skin_pigmentation0.71362317
81MP0005501_abnormal_skin_physiology0.70817710
82MP0008873_increased_physiological_sensi0.69889904
83MP0004185_abnormal_adipocyte_glucose0.68526597
84MP0009763_increased_sensitivity_to0.67700090
85MP0001243_abnormal_dermal_layer0.65306888
86MP0003221_abnormal_cardiomyocyte_apopto0.65086056
87MP0001986_abnormal_taste_sensitivity0.65071021
88MP0009764_decreased_sensitivity_to0.62815972
89MP0003656_abnormal_erythrocyte_physiolo0.62384544
90MP0001663_abnormal_digestive_system0.62042219
91MP0001919_abnormal_reproductive_system0.59138940
92MP0001851_eye_inflammation0.58751648
93MP0009278_abnormal_bone_marrow0.58379314
94MP0003567_abnormal_fetal_cardiomyocyte0.57688808
95MP0000477_abnormal_intestine_morphology0.57422127
96MP0002822_catalepsy0.57371551
97MP0001502_abnormal_circadian_rhythm0.56644259
98MP0005647_abnormal_sex_gland0.56106314
99MP0001191_abnormal_skin_condition0.55265033
100MP0005330_cardiomyopathy0.54581004

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)5.92593344
2T lymphocytopenia (HP:0005403)5.55004332
3Chronic diarrhea (HP:0002028)5.53780103
4Aplastic anemia (HP:0001915)5.53270311
5Abnormality of T cell number (HP:0011839)5.05439456
6Combined immunodeficiency (HP:0005387)4.83379637
7Abnormality of T cells (HP:0002843)4.18795138
8Panhypogammaglobulinemia (HP:0003139)4.14712037
9Inflammation of the large intestine (HP:0002037)4.13608672
10Gastrointestinal inflammation (HP:0004386)3.95917945
11Autoimmune hemolytic anemia (HP:0001890)3.83897241
12Thyroiditis (HP:0100646)3.82973072
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.76368196
14Recurrent viral infections (HP:0004429)3.57364044
15IgG deficiency (HP:0004315)3.56784235
16Microvesicular hepatic steatosis (HP:0001414)3.56217387
17B lymphocytopenia (HP:0010976)3.50034771
18Abnormality of B cell number (HP:0010975)3.45227754
19Abnormality of T cell physiology (HP:0011840)3.36699187
20Encephalitis (HP:0002383)3.31825900
21Agammaglobulinemia (HP:0004432)3.17897924
22Abnormality of eosinophils (HP:0001879)3.15123723
23Abnormality of the prostate (HP:0008775)3.04703873
24Increased IgM level (HP:0003496)3.01803551
25Impaired proprioception (HP:0010831)2.93130980
26Pancytopenia (HP:0001876)2.89213240
27Fatigue (HP:0012378)2.88382018
28Recurrent cutaneous fungal infections (HP:0011370)2.87019738
29Chronic mucocutaneous candidiasis (HP:0002728)2.87019738
30Lymphoma (HP:0002665)2.84597097
31IgM deficiency (HP:0002850)2.72543672
32Petechiae (HP:0000967)2.66012537
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61272276
34Acute hepatic failure (HP:0006554)2.60730832
35Meningitis (HP:0001287)2.59212531
36Recurrent fungal infections (HP:0002841)2.51321968
37Microretrognathia (HP:0000308)2.45974828
38IgA deficiency (HP:0002720)2.45652612
39Granulocytopenia (HP:0001913)2.45469621
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45274859
41Abnormality of alanine metabolism (HP:0010916)2.45274859
42Hyperalaninemia (HP:0003348)2.45274859
43Obstructive lung disease (HP:0006536)2.40253106
44Chronic obstructive pulmonary disease (HP:0006510)2.40253106
45Leukocytosis (HP:0001974)2.39687223
46Progressive muscle weakness (HP:0003323)2.33353384
47Ureteral stenosis (HP:0000071)2.32620458
48Squamous cell carcinoma (HP:0002860)2.29971071
49Hypoproteinemia (HP:0003075)2.29614738
50Abnormality of DNA repair (HP:0003254)2.28436291
51Areflexia of lower limbs (HP:0002522)2.28397785
52Hypoplasia of the thymus (HP:0000778)2.28227681
53Myelodysplasia (HP:0002863)2.21958683
54Colitis (HP:0002583)2.21495538
55Hepatitis (HP:0012115)2.18764882
56Reticulocytopenia (HP:0001896)2.17561106
57Neutropenia (HP:0001875)2.10578835
58Abnormality of the anterior horn cell (HP:0006802)2.09636927
59Degeneration of anterior horn cells (HP:0002398)2.09636927
60Mediastinal lymphadenopathy (HP:0100721)2.09429337
61Spinal muscular atrophy (HP:0007269)2.08992095
62Abnormality of male internal genitalia (HP:0000022)2.07284403
63Ureteral obstruction (HP:0006000)2.07040263
64Oral leukoplakia (HP:0002745)2.04923284
65Prolonged bleeding time (HP:0003010)2.04371062
66Seborrheic dermatitis (HP:0001051)2.03896100
67Chromsome breakage (HP:0040012)2.03059090
68Stomatitis (HP:0010280)2.01574999
69Tongue fasciculations (HP:0001308)2.01372416
70Pustule (HP:0200039)2.01324210
71Gastrointestinal infarctions (HP:0005244)1.98440043
72Amaurosis fugax (HP:0100576)1.96377173
73Epistaxis (HP:0000421)1.95323832
74Entropion (HP:0000621)1.94522769
75Chest pain (HP:0100749)1.93539367
76Rough bone trabeculation (HP:0100670)1.90394589
773-Methylglutaconic aciduria (HP:0003535)1.85175255
78Aplasia/Hypoplasia of the thymus (HP:0010515)1.81954968
79Basal cell carcinoma (HP:0002671)1.81863381
80Hypergonadotropic hypogonadism (HP:0000815)1.75460330
81Premature graying of hair (HP:0002216)1.75014731
82Muscle fiber atrophy (HP:0100295)1.71331117
83Villous atrophy (HP:0011473)1.71000620
84Abnormality of small intestinal villus morphology (HP:0011472)1.71000620
85Abnormality of cells of the lymphoid lineage (HP:0012140)1.68601982
86Premature ovarian failure (HP:0008209)1.67379625
87Lymphopenia (HP:0001888)1.67079493
88Abnormality of macrophages (HP:0004311)1.66855094
89Slow saccadic eye movements (HP:0000514)1.66280548
90Duplicated collecting system (HP:0000081)1.65610804
91Pulmonary infiltrates (HP:0002113)1.63995537
92Autoimmune thrombocytopenia (HP:0001973)1.62403528
93Muscle fibrillation (HP:0010546)1.62233900
94Abnormal platelet volume (HP:0011876)1.61814203
95Abnormality of the preputium (HP:0100587)1.61489452
96Hepatosplenomegaly (HP:0001433)1.61066380
97Abnormality of homocysteine metabolism (HP:0010919)1.58482254
98Homocystinuria (HP:0002156)1.58482254
99Abnormal glycosylation (HP:0012345)1.57641719
100Abnormal protein N-linked glycosylation (HP:0012347)1.57641719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.75335120
2SCYL23.85357783
3KDR3.15647522
4PIM22.71521223
5TLK12.57937984
6BUB12.50685435
7FES2.40570356
8MAP4K12.23674693
9MUSK2.16539665
10VRK12.15318175
11RAF12.11624644
12VRK22.06335122
13IRAK31.80298212
14ZAK1.69903415
15PIM11.67233264
16TAOK31.54989893
17ITK1.53686821
18MAP3K141.53463128
19IKBKB1.53213931
20BRD41.50511046
21PBK1.47116390
22TESK21.41485286
23GRK61.41232112
24SMG11.30884215
25NUAK11.25854949
26IKBKE1.22900775
27BCKDK1.21244010
28MARK31.16221773
29CDK41.09625109
30MAP3K61.08470957
31LCK1.07686621
32MAPK111.06499435
33SIK31.05741392
34TBK11.05389440
35PDK21.03818847
36MST41.02307419
37MAP3K101.01833126
38EIF2AK11.00152145
39SRPK11.00097277
40MAP3K110.97442451
41RPS6KA50.94442781
42MKNK20.92725578
43BTK0.90550054
44ATR0.87056287
45CSK0.83031466
46JAK30.81225617
47CHUK0.80389148
48SYK0.78421828
49DYRK30.77259230
50PAK60.77048831
51PIK3CG0.76931999
52RIPK40.76406976
53JAK20.74458612
54EIF2AK30.69912321
55MAP2K20.68817225
56CDK120.66357712
57RPS6KA40.65734087
58TNK20.64868603
59RPS6KA10.64321724
60STK390.63873126
61CAMK40.62986042
62ZAP700.62707270
63TRPM70.62389977
64KSR20.62355006
65MAP3K50.62281642
66NME10.61379273
67JAK10.60005536
68CHEK10.59905298
69WNK40.59634753
70TAOK20.59028506
71BMPR20.57218188
72LYN0.57109791
73HCK0.55865744
74AURKA0.55093338
75MAPKAPK30.53270084
76KIT0.50109874
77PASK0.49412517
78CHEK20.48752283
79PRKCQ0.48288122
80ADRBK20.47020669
81IRAK40.45870059
82NME20.43999962
83RPS6KC10.41666643
84RPS6KL10.41666643
85TEC0.40012841
86PRKAA20.39853086
87EEF2K0.39523997
88CDK80.38676533
89DAPK10.37048846
90CDC70.36953018
91RPS6KA60.36588158
92AKT30.36363897
93TYRO30.36346623
94AURKB0.36110176
95CDK70.35520260
96ATM0.34481310
97MAP3K80.34150157
98EIF2AK20.32813189
99STK40.32585416
100PRPF4B0.31874029

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.80915999
2RNA polymerase_Homo sapiens_hsa030203.49206074
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95766359
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.92324790
5T cell receptor signaling pathway_Homo sapiens_hsa046602.66287744
6Autoimmune thyroid disease_Homo sapiens_hsa053202.60142690
7Hematopoietic cell lineage_Homo sapiens_hsa046402.59556441
8Systemic lupus erythematosus_Homo sapiens_hsa053222.47531160
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.42595600
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.36413459
11DNA replication_Homo sapiens_hsa030302.36109942
12Allograft rejection_Homo sapiens_hsa053302.22175576
13Mismatch repair_Homo sapiens_hsa034302.14396406
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96236676
15Measles_Homo sapiens_hsa051621.89408127
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.87970173
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.80067646
18Base excision repair_Homo sapiens_hsa034101.79194328
19Sulfur relay system_Homo sapiens_hsa041221.77102672
20Pyrimidine metabolism_Homo sapiens_hsa002401.74397420
21Spliceosome_Homo sapiens_hsa030401.64645004
22One carbon pool by folate_Homo sapiens_hsa006701.63356321
23RNA transport_Homo sapiens_hsa030131.61242362
24Alcoholism_Homo sapiens_hsa050341.57966602
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53152689
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.47840400
27Homologous recombination_Homo sapiens_hsa034401.47547489
28Viral carcinogenesis_Homo sapiens_hsa052031.41859338
29Graft-versus-host disease_Homo sapiens_hsa053321.40175188
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32466518
31Herpes simplex infection_Homo sapiens_hsa051681.29380097
32B cell receptor signaling pathway_Homo sapiens_hsa046621.27771796
33Proteasome_Homo sapiens_hsa030501.23878005
34Antigen processing and presentation_Homo sapiens_hsa046121.23663170
35Asthma_Homo sapiens_hsa053101.10709233
36RNA degradation_Homo sapiens_hsa030181.08632117
37Fanconi anemia pathway_Homo sapiens_hsa034601.07492605
38Ribosome_Homo sapiens_hsa030101.06261752
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04676470
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04539898
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03329014
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02653110
43Apoptosis_Homo sapiens_hsa042101.02462453
44mRNA surveillance pathway_Homo sapiens_hsa030151.01934539
45Viral myocarditis_Homo sapiens_hsa054161.01332335
46Acute myeloid leukemia_Homo sapiens_hsa052211.01151074
47Nucleotide excision repair_Homo sapiens_hsa034200.98901419
48Epstein-Barr virus infection_Homo sapiens_hsa051690.96999508
49Cell cycle_Homo sapiens_hsa041100.92483692
50Rheumatoid arthritis_Homo sapiens_hsa053230.91316206
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91284713
52Type I diabetes mellitus_Homo sapiens_hsa049400.90989443
53Purine metabolism_Homo sapiens_hsa002300.90105207
54TNF signaling pathway_Homo sapiens_hsa046680.90018823
55Hepatitis B_Homo sapiens_hsa051610.87733335
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85480887
57HTLV-I infection_Homo sapiens_hsa051660.82744788
58Non-homologous end-joining_Homo sapiens_hsa034500.79201994
59p53 signaling pathway_Homo sapiens_hsa041150.74824134
60Salmonella infection_Homo sapiens_hsa051320.73560563
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.71639805
62Colorectal cancer_Homo sapiens_hsa052100.68171457
63Small cell lung cancer_Homo sapiens_hsa052220.64256443
64Regulation of autophagy_Homo sapiens_hsa041400.62414918
65Shigellosis_Homo sapiens_hsa051310.61105233
66Non-small cell lung cancer_Homo sapiens_hsa052230.59296554
67Parkinsons disease_Homo sapiens_hsa050120.59276567
68Osteoclast differentiation_Homo sapiens_hsa043800.56404195
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53848133
70Legionellosis_Homo sapiens_hsa051340.53800088
71Chemokine signaling pathway_Homo sapiens_hsa040620.50573347
72VEGF signaling pathway_Homo sapiens_hsa043700.47631529
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46592493
74Protein export_Homo sapiens_hsa030600.46384573
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46160502
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46011102
77Leishmaniasis_Homo sapiens_hsa051400.45572560
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44731778
79Influenza A_Homo sapiens_hsa051640.44047500
80Biosynthesis of amino acids_Homo sapiens_hsa012300.42063513
81Oxidative phosphorylation_Homo sapiens_hsa001900.40888748
82Bladder cancer_Homo sapiens_hsa052190.40838165
83Fructose and mannose metabolism_Homo sapiens_hsa000510.37606214
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37013308
85Chronic myeloid leukemia_Homo sapiens_hsa052200.36613251
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.36010377
87Basal transcription factors_Homo sapiens_hsa030220.32976894
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32923635
89Fatty acid elongation_Homo sapiens_hsa000620.30970999
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.30961173
91Phototransduction_Homo sapiens_hsa047440.30603665
92Prolactin signaling pathway_Homo sapiens_hsa049170.29614419
93Pancreatic cancer_Homo sapiens_hsa052120.27579171
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26538523
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26375291
96Phenylalanine metabolism_Homo sapiens_hsa003600.24871474
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24655073
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21052293
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.19065093
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.18301089

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