ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.78250515
2	purine deoxyribonucleotide catabolic process (GO:0009155)	4.80240181
3	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.68518016
4	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.68518016
5	NADH dehydrogenase complex assembly (GO:0010257)	4.68518016
6	protein complex biogenesis (GO:0070271)	4.60783903
7	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.39777507
8	negative regulation of mast cell activation (GO:0033004)	4.39619035
9	mitochondrial respiratory chain complex assembly (GO:0033108)	4.17816586
10	deoxyribonucleotide catabolic process (GO:0009264)	3.92795305
11	negative regulation of B cell apoptotic process (GO:0002903)	3.78386242
12	seminiferous tubule development (GO:0072520)	3.74752592
13	metallo-sulfur cluster assembly (GO:0031163)	3.70282241
14	iron-sulfur cluster assembly (GO:0016226)	3.70282241
15	platelet dense granule organization (GO:0060155)	3.69165347
16	positive regulation of prostaglandin secretion (GO:0032308)	3.68027959
17	mannosylation (GO:0097502)	3.65233441
18	branched-chain amino acid catabolic process (GO:0009083)	3.64646799
19	deoxyribose phosphate catabolic process (GO:0046386)	3.63839915
20	mature B cell differentiation involved in immune response (GO:0002313)	3.63827891
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.56775258
22	regulation of mitochondrial translation (GO:0070129)	3.55361513
23	valine metabolic process (GO:0006573)	3.47997575
24	base-excision repair, AP site formation (GO:0006285)	3.44129407
25	positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081	3.32876069
26	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	3.29327220
27	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	3.29327220
28	negative regulation of cell cycle arrest (GO:0071157)	3.28678021
29	termination of RNA polymerase III transcription (GO:0006386)	3.25528904
30	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.25528904
31	purine deoxyribonucleotide metabolic process (GO:0009151)	3.25252137
32	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.19189600
33	negative regulation of telomerase activity (GO:0051974)	3.19026460
34	GTP biosynthetic process (GO:0006183)	3.17713022
35	mismatch repair (GO:0006298)	3.17590372
36	regulation of telomerase activity (GO:0051972)	3.16696600
37	branched-chain amino acid metabolic process (GO:0009081)	3.13564817
38	regulation of hypersensitivity (GO:0002883)	3.06685586
39	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.06239790
40	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.03185448
41	2-deoxyribonucleotide metabolic process (GO:0009394)	2.99106015
42	adenosine metabolic process (GO:0046085)	2.98981432
43	GDP-mannose metabolic process (GO:0019673)	2.96054192
44	indolalkylamine catabolic process (GO:0046218)	2.93254889
45	tryptophan catabolic process (GO:0006569)	2.93254889
46	indole-containing compound catabolic process (GO:0042436)	2.93254889
47	tryptophan metabolic process (GO:0006568)	2.92696538
48	UTP biosynthetic process (GO:0006228)	2.89932214
49	folic acid metabolic process (GO:0046655)	2.87902928
50	folic acid-containing compound biosynthetic process (GO:0009396)	2.87389260
51	positive regulation of mRNA catabolic process (GO:0061014)	2.85315068
52	kynurenine metabolic process (GO:0070189)	2.85090007
53	deoxyribose phosphate metabolic process (GO:0019692)	2.84353319
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.84044991
55	CTP metabolic process (GO:0046036)	2.83921375
56	CTP biosynthetic process (GO:0006241)	2.83921375
57	negative regulation of acute inflammatory response (GO:0002674)	2.83049605
58	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.82806710
59	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.82623100
60	regulation of germinal center formation (GO:0002634)	2.82052394
61	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.80840257
62	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.80088399
63	autophagic vacuole fusion (GO:0000046)	2.79650329
64	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.79052801
65	cellular response to exogenous dsRNA (GO:0071360)	2.77014666
66	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.76561449
67	GPI anchor biosynthetic process (GO:0006506)	2.75582113
68	respiratory chain complex IV assembly (GO:0008535)	2.75252664
69	regulation of B cell apoptotic process (GO:0002902)	2.74455922
70	tRNA modification (GO:0006400)	2.73998357
71	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.73420061
72	pentose metabolic process (GO:0019321)	2.70846307
73	cytochrome complex assembly (GO:0017004)	2.69857707
74	positive regulation of defense response to virus by host (GO:0002230)	2.67595261
75	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.66926173
76	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.65734771
77	UTP metabolic process (GO:0046051)	2.64998128
78	negative regulation of JAK-STAT cascade (GO:0046426)	2.63288584
79	natural killer cell activation involved in immune response (GO:0002323)	2.62995180
80	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.62887037
81	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.62400306
82	mucosal-associated lymphoid tissue development (GO:0048537)	2.61055856
83	Peyers patch development (GO:0048541)	2.61055856
84	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.60517245
85	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.60446522
86	cellular biogenic amine catabolic process (GO:0042402)	2.58159799
87	amine catabolic process (GO:0009310)	2.58159799
88	positive regulation of megakaryocyte differentiation (GO:0045654)	2.58105681
89	pseudouridine synthesis (GO:0001522)	2.56622566
90	response to interferon-beta (GO:0035456)	2.56503934
91	glucosamine-containing compound catabolic process (GO:1901072)	2.55741919
92	GPI anchor metabolic process (GO:0006505)	2.55575075
93	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.55499220
94	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.55499220
95	regulation of prostaglandin secretion (GO:0032306)	2.55341233
96	response to lipoprotein particle (GO:0055094)	2.55204665
97	immunoglobulin mediated immune response (GO:0016064)	2.54301381
98	deoxyribose phosphate biosynthetic process (GO:0046385)	2.54241089
99	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.54241089
100	maturation of 5.8S rRNA (GO:0000460)	2.52916338

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.21634876
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.64095861
3	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.96827244
4	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.92737248
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.84878364
6	CIITA_25753668_ChIP-Seq_RAJI_Human	2.71320015
7	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.66655098
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55887526
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.37478722
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.24891771
11	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.20276219
12	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.08560050
13	SCL_19346495_ChIP-Seq_HPC-7_Human	1.97406900
14	IRF1_19129219_ChIP-ChIP_H3396_Human	1.96164686
15	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.94629168
16	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.93467278
17	BCL6_27268052_Chip-Seq_Bcells_Human	1.88420075
18	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.84890363
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.84288746
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.83641631
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.83443781
22	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.82928746
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.78648053
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.74909667
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.73936605
26	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.73019158
27	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.72451667
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.71971875
29	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.71902927
30	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.71401453
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.69730773
32	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.68200715
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.67407204
34	VDR_21846776_ChIP-Seq_THP-1_Human	1.64652114
35	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.64324321
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.62357865
37	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.59876525
38	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.58171787
39	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.57819203
40	ZNF274_21170338_ChIP-Seq_K562_Hela	1.57406599
41	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.55848692
42	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.54430331
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.53935548
44	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.53543899
45	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.52119559
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.48208954
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.44715090
48	P68_20966046_ChIP-Seq_HELA_Human	1.43038124
49	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.42100406
50	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.41158343
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.39864626
52	KDM5A_27292631_Chip-Seq_BREAST_Human	1.38456121
53	BCOR_27268052_Chip-Seq_Bcells_Human	1.37586017
54	* UTX_26944678_Chip-Seq_JUKART_Human	1.37269673
55	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35938412
56	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.35933197
57	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.35500091
58	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.34847382
59	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.33867290
60	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.31402480
61	* SPI1_20517297_ChIP-Seq_HL60_Human	1.30751031
62	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.30229401
63	P300_27268052_Chip-Seq_Bcells_Human	1.30066708
64	PHF8_20622854_ChIP-Seq_HELA_Human	1.29357355
65	E2F7_22180533_ChIP-Seq_HELA_Human	1.27538110
66	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.26815016
67	XRN2_22483619_ChIP-Seq_HELA_Human	1.26406867
68	* MAF_26560356_Chip-Seq_TH2_Human	1.22338950
69	E2F1_20622854_ChIP-Seq_HELA_Human	1.22140690
70	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.22010708
71	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.21824331
72	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.19069215
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18241141
74	* MAF_26560356_Chip-Seq_TH1_Human	1.18072397
75	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.16855434
76	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.15516667
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14992563
78	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.13646511
79	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.12898198
80	GATA3_27048872_Chip-Seq_THYMUS_Human	1.11645100
81	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.11042799
82	MYC_22102868_ChIP-Seq_BL_Human	1.08945849
83	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.08076251
84	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.07263727
85	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.06659889
86	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06142022
87	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.05362082
88	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.04371324
89	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.03321673
90	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02452525
91	TTF2_22483619_ChIP-Seq_HELA_Human	1.01955751
92	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.01924600
93	ETS1_22383799_ChIP-Seq_G1ME_Mouse	1.01905265
94	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.99557331
95	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.99455705
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99165416
97	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.96886269
98	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.96672371
99	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.96431105
100	CTCF_21964334_Chip-Seq_Bcells_Human	0.96259026

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	4.67776033
2	MP0005670_abnormal_white_adipose	3.47051024
3	MP0005377_hearing/vestibular/ear_phenot	3.17690425
4	MP0003878_abnormal_ear_physiology	3.17690425
5	MP0001661_extended_life_span	3.17155636
6	MP0005646_abnormal_pituitary_gland	2.57408579
7	MP0001485_abnormal_pinna_reflex	2.37571349
8	MP0001835_abnormal_antigen_presentation	2.32055652
9	MP0003724_increased_susceptibility_to	2.26839568
10	MP0004145_abnormal_muscle_electrophysio	2.19627147
11	MP0000465_gastrointestinal_hemorrhage	2.12308769
12	MP0006072_abnormal_retinal_apoptosis	2.01719674
13	MP0010094_abnormal_chromosome_stability	1.96313566
14	MP0005671_abnormal_response_to	1.90960027
15	MP0000685_abnormal_immune_system	1.84814064
16	MP0009046_muscle_twitch	1.81895468
17	MP0005075_abnormal_melanosome_morpholog	1.80454738
18	MP0000516_abnormal_urinary_system	1.79519995
19	MP0005367_renal/urinary_system_phenotyp	1.79519995
20	MP0002102_abnormal_ear_morphology	1.76044804
21	MP0006036_abnormal_mitochondrial_physio	1.74639067
22	MP0005076_abnormal_cell_differentiation	1.68275345
23	MP0005397_hematopoietic_system_phenotyp	1.64850023
24	MP0001545_abnormal_hematopoietic_system	1.64850023
25	MP0005551_abnormal_eye_electrophysiolog	1.64521279
26	MP0005253_abnormal_eye_physiology	1.59317688
27	MP0003763_abnormal_thymus_physiology	1.54119927
28	MP0002638_abnormal_pupillary_reflex	1.53692740
29	MP0005000_abnormal_immune_tolerance	1.51848888
30	MP0000372_irregular_coat_pigmentation	1.51343982
31	MP0001800_abnormal_humoral_immune	1.51231665
32	MP0008058_abnormal_DNA_repair	1.51024270
33	MP0000013_abnormal_adipose_tissue	1.50958641
34	MP0008872_abnormal_physiological_respon	1.49382107
35	MP0004133_heterotaxia	1.49248984
36	MP0002160_abnormal_reproductive_system	1.44052754
37	MP0002148_abnormal_hypersensitivity_rea	1.41700321
38	MP0006035_abnormal_mitochondrial_morpho	1.40800937
39	MP0001764_abnormal_homeostasis	1.38248755
40	MP0005220_abnormal_exocrine_pancreas	1.37976119
41	MP0002723_abnormal_immune_serum	1.37655479
42	MP0008875_abnormal_xenobiotic_pharmacok	1.37416039
43	MP0006276_abnormal_autonomic_nervous	1.31599888
44	MP0004142_abnormal_muscle_tone	1.30429997
45	MP0001727_abnormal_embryo_implantation	1.29758344
46	MP0002452_abnormal_antigen_presenting	1.28399066
47	MP0000358_abnormal_cell_content/	1.26706293
48	MP0003786_premature_aging	1.23981843
49	MP0009278_abnormal_bone_marrow	1.21863649
50	MP0000631_abnormal_neuroendocrine_gland	1.20425250
51	MP0002019_abnormal_tumor_incidence	1.17583160
52	MP0002398_abnormal_bone_marrow	1.16582544
53	MP0001819_abnormal_immune_cell	1.16509639
54	MP0002876_abnormal_thyroid_physiology	1.15148809
55	MP0000689_abnormal_spleen_morphology	1.14609988
56	MP0002420_abnormal_adaptive_immunity	1.12430055
57	MP0008877_abnormal_DNA_methylation	1.06503692
58	MP0000716_abnormal_immune_system	1.06499674
59	MP0005084_abnormal_gallbladder_morpholo	1.06304898
60	MP0005025_abnormal_response_to	1.04885054
61	MP0003195_calcinosis	1.04206841
62	MP0000538_abnormal_urinary_bladder	1.01089803
63	MP0004185_abnormal_adipocyte_glucose	0.99277443
64	MP0001502_abnormal_circadian_rhythm	0.99118864
65	MP0000015_abnormal_ear_pigmentation	0.97664795
66	MP0005389_reproductive_system_phenotype	0.96487137
67	MP0002429_abnormal_blood_cell	0.94829598
68	MP0005410_abnormal_fertilization	0.92410066
69	MP0002722_abnormal_immune_system	0.92028389
70	MP0009785_altered_susceptibility_to	0.91401977
71	MP0008789_abnormal_olfactory_epithelium	0.91362305
72	MP0000371_diluted_coat_color	0.90512693
73	MP0009765_abnormal_xenobiotic_induced	0.89029544
74	MP0008995_early_reproductive_senescence	0.87455613
75	MP0003186_abnormal_redox_activity	0.84995632
76	MP0009764_decreased_sensitivity_to	0.84530394
77	MP0010386_abnormal_urinary_bladder	0.83089624
78	MP0005464_abnormal_platelet_physiology	0.80885112
79	MP0001765_abnormal_ion_homeostasis	0.79154985
80	MP0008932_abnormal_embryonic_tissue	0.79063656
81	MP0002166_altered_tumor_susceptibility	0.77470100
82	MP0010329_abnormal_lipoprotein_level	0.77079049
83	MP0005387_immune_system_phenotype	0.76426800
84	MP0001790_abnormal_immune_system	0.76426800
85	MP0001968_abnormal_touch/_nociception	0.75961136
86	MP0002653_abnormal_ependyma_morphology	0.73473366
87	MP0002272_abnormal_nervous_system	0.73113784
88	MP0001501_abnormal_sleep_pattern	0.72913578
89	MP0008961_abnormal_basal_metabolism	0.72860088
90	MP0005334_abnormal_fat_pad	0.72845445
91	MP0000681_abnormal_thyroid_gland	0.72246752
92	MP0002970_abnormal_white_adipose	0.71662009
93	MP0005332_abnormal_amino_acid	0.69464976
94	MP0002006_tumorigenesis	0.68400536
95	MP0002095_abnormal_skin_pigmentation	0.68291304
96	MP0001119_abnormal_female_reproductive	0.67731371
97	MP0001963_abnormal_hearing_physiology	0.67678002
98	MP0000639_abnormal_adrenal_gland	0.67487367
99	MP0001905_abnormal_dopamine_level	0.67453661
100	MP0003806_abnormal_nucleotide_metabolis	0.67053698

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal mitochondria in muscle tissue (HP:0008316)	4.21889859
2	Acute necrotizing encephalopathy (HP:0006965)	4.01092963
3	Hepatocellular necrosis (HP:0001404)	3.91350504
4	Mitochondrial inheritance (HP:0001427)	3.85011870
5	Hepatic necrosis (HP:0002605)	3.49796963
6	Acute encephalopathy (HP:0006846)	3.47490481
7	Elevated erythrocyte sedimentation rate (HP:0003565)	3.33011121
8	Progressive macrocephaly (HP:0004481)	3.24578700
9	Severe combined immunodeficiency (HP:0004430)	3.23381854
10	Increased CSF lactate (HP:0002490)	3.23229145
11	Short 1st metacarpal (HP:0010034)	3.21859430
12	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.21859430
13	B lymphocytopenia (HP:0010976)	3.19251564
14	Abnormality of B cell number (HP:0010975)	3.07906856
15	IgG deficiency (HP:0004315)	3.07719771
16	Absent thumb (HP:0009777)	3.02732383
17	Abolished electroretinogram (ERG) (HP:0000550)	2.96679158
18	Abnormality of the 1st metacarpal (HP:0010009)	2.79548276
19	Abnormal protein glycosylation (HP:0012346)	2.73442198
20	Abnormal glycosylation (HP:0012345)	2.73442198
21	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.73442198
22	Abnormal protein N-linked glycosylation (HP:0012347)	2.73442198
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.73071378
24	Agammaglobulinemia (HP:0004432)	2.71570526
25	Cerebral edema (HP:0002181)	2.69600344
26	Lactic acidosis (HP:0003128)	2.65588468
27	Hypoplasia of the thymus (HP:0000778)	2.64931798
28	Petechiae (HP:0000967)	2.61983326
29	Panhypogammaglobulinemia (HP:0003139)	2.57463049
30	Abnormality of the prostate (HP:0008775)	2.50411887
31	Opisthotonus (HP:0002179)	2.49423397
32	Congenital stationary night blindness (HP:0007642)	2.39597493
33	Thyroiditis (HP:0100646)	2.36900523
34	Duplicated collecting system (HP:0000081)	2.36203841
35	Abnormality of the renal collecting system (HP:0004742)	2.36200797
36	Prostate neoplasm (HP:0100787)	2.31239020
37	Increased serum lactate (HP:0002151)	2.29298888
38	Respiratory failure (HP:0002878)	2.27037659
39	Severe muscular hypotonia (HP:0006829)	2.26049660
40	Abnormality of the parathyroid morphology (HP:0011766)	2.26047248
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.24936503
42	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.24936503
43	Aplastic anemia (HP:0001915)	2.22865848
44	Exercise intolerance (HP:0003546)	2.22302925
45	Stomatitis (HP:0010280)	2.21715236
46	Combined immunodeficiency (HP:0005387)	2.18027759
47	Oligomenorrhea (HP:0000876)	2.15276587
48	Increased intramyocellular lipid droplets (HP:0012240)	2.14042630
49	Hypergonadotropic hypogonadism (HP:0000815)	2.13517023
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.12523357
51	Progressive microcephaly (HP:0000253)	2.12172287
52	Progressive inability to walk (HP:0002505)	2.10763929
53	Type I transferrin isoform profile (HP:0003642)	2.10114912
54	Short phalanx of the thumb (HP:0009660)	2.07988588
55	Abnormality of the columella (HP:0009929)	2.05904921
56	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.05650785
57	Increased muscle lipid content (HP:0009058)	2.01484373
58	Pancytopenia (HP:0001876)	1.98075309
59	Nephronophthisis (HP:0000090)	1.97399417
60	Progressive muscle weakness (HP:0003323)	1.96176706
61	3-Methylglutaconic aciduria (HP:0003535)	1.94963063
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.94755852
63	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.93440470
64	Dicarboxylic aciduria (HP:0003215)	1.93440470
65	Optic disc pallor (HP:0000543)	1.93439181
66	Abnormality of T cell physiology (HP:0011840)	1.91979359
67	Cerebral palsy (HP:0100021)	1.88360018
68	Hypoplasia of the pons (HP:0012110)	1.85967300
69	Stenosis of the external auditory canal (HP:0000402)	1.83470320
70	Rib fusion (HP:0000902)	1.82435699
71	Intestinal fistula (HP:0100819)	1.81075226
72	Microretrognathia (HP:0000308)	1.79377065
73	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.79266998
74	Abnormality of alanine metabolism (HP:0010916)	1.79266998
75	Hyperalaninemia (HP:0003348)	1.79266998
76	Ectopic kidney (HP:0000086)	1.77612082
77	True hermaphroditism (HP:0010459)	1.77314641
78	Emotional lability (HP:0000712)	1.77273650
79	Lethargy (HP:0001254)	1.76876494
80	Pancreatic cysts (HP:0001737)	1.76395437
81	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.76220220
82	Abnormality of the pons (HP:0007361)	1.75468238
83	Abnormality of dental color (HP:0011073)	1.75340142
84	Abnormality of glycolipid metabolism (HP:0010969)	1.75091673
85	Abnormality of liposaccharide metabolism (HP:0010968)	1.75091673
86	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.75091673
87	Pancreatic fibrosis (HP:0100732)	1.75079422
88	Horseshoe kidney (HP:0000085)	1.75030154
89	Recurrent fungal infections (HP:0002841)	1.73983275
90	Cleft eyelid (HP:0000625)	1.73821482
91	Abnormality of DNA repair (HP:0003254)	1.73345411
92	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.72671921
93	Lissencephaly (HP:0001339)	1.72074710
94	Rectal fistula (HP:0100590)	1.71632927
95	Rectovaginal fistula (HP:0000143)	1.71632927
96	IgM deficiency (HP:0002850)	1.67858992
97	Renal Fanconi syndrome (HP:0001994)	1.67508750
98	Short thumb (HP:0009778)	1.67494960
99	Multiple enchondromatosis (HP:0005701)	1.67374498
100	Recurrent sinusitis (HP:0011108)	1.66825045

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.10257581
2	ZAK	4.28842068
3	TLK1	3.43732261
4	VRK1	3.33961857
5	KDR	3.12949972
6	PIM2	2.65865154
7	MAP4K1	2.58983049
8	TAOK3	2.48982314
9	VRK2	2.38511381
10	NME1	2.27057101
11	MAP2K7	2.19232012
12	NUAK1	2.19188582
13	TXK	2.04275422
14	FRK	1.92686015
15	MAP4K2	1.82401026
16	MUSK	1.79548464
17	MAP3K4	1.73893708
18	TESK2	1.69780811
19	RPS6KA5	1.67453791
20	GRK1	1.67398204
21	MST4	1.66342924
22	KIT	1.62464234
23	NME2	1.58957783
24	IKBKB	1.55132509
25	TBK1	1.47414355
26	SCYL2	1.45495553
27	MAPK11	1.24798960
28	GRK6	1.24012837
29	CCNB1	1.21888202
30	CSNK1G3	1.20657348
31	DAPK1	1.20286975
32	MAPKAPK3	1.19237873
33	FES	1.12104211
34	FLT3	1.11103430
35	CDC7	1.10527561
36	CSNK1A1L	1.07737849
37	AURKA	1.07275078
38	DAPK3	1.04734096
39	SYK	1.01914261
40	CSNK1G2	0.98936632
41	CDK8	0.97723881
42	PIM1	0.97383821
43	PDK2	0.95032591
44	LYN	0.92121572
45	BTK	0.92027488
46	MAPK13	0.90976357
47	ATR	0.90467072
48	TNK2	0.90302891
49	PHKG2	0.84599400
50	PHKG1	0.84599400
51	TEC	0.83286110
52	MAP3K11	0.79133406
53	PKN1	0.78625204
54	ABL2	0.77161722
55	INSRR	0.75768828
56	CSNK1G1	0.74049205
57	WNK3	0.73135909
58	ADRBK2	0.72825233
59	CDK9	0.71203415
60	TIE1	0.62419145
61	CSF1R	0.61429996
62	IKBKE	0.59630743
63	DYRK2	0.56623244
64	OXSR1	0.56081988
65	BMPR1B	0.54612664
66	CHEK2	0.52369847
67	LCK	0.52069152
68	CDK19	0.51763143
69	AKT2	0.50134736
70	EPHA3	0.49501579
71	CHUK	0.49149525
72	PRKCQ	0.47361020
73	ADRBK1	0.46265295
74	MAP3K5	0.45952401
75	MAPK15	0.44476638
76	ITK	0.41675395
77	MAP3K6	0.41475967
78	MAPK3	0.39992320
79	BLK	0.39988205
80	PRKCE	0.36596631
81	ABL1	0.36575106
82	MAPKAPK2	0.36455004
83	MAPK9	0.36380637
84	PRKAA1	0.36215002
85	HCK	0.30910337
86	FER	0.30591418
87	MAP2K4	0.29071950
88	MAP2K2	0.27323557
89	CAMK1	0.26378773
90	PDK1	0.25769673
91	ARAF	0.25442086
92	AURKB	0.25045371
93	CSNK2A1	0.24716984
94	PLK1	0.24083779
95	MAP3K14	0.22516965
96	SIK2	0.22270607
97	EGFR	0.22208951
98	PRKACA	0.21804300
99	PRKD1	0.21724391
100	PRKCA	0.21181321

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	4.40058078
2	Asthma_Homo sapiens_hsa05310	3.09963616
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.98297067
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.76695139
5	Alcoholism_Homo sapiens_hsa05034	2.68928123
6	Homologous recombination_Homo sapiens_hsa03440	2.63154904
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.50796642
8	RNA polymerase_Homo sapiens_hsa03020	2.44134962
9	Allograft rejection_Homo sapiens_hsa05330	2.28746015
10	DNA replication_Homo sapiens_hsa03030	2.22044476
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20547197
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.10418253
13	Base excision repair_Homo sapiens_hsa03410	2.06091338
14	Type I diabetes mellitus_Homo sapiens_hsa04940	2.05301841
15	Graft-versus-host disease_Homo sapiens_hsa05332	2.04345906
16	Mismatch repair_Homo sapiens_hsa03430	1.99768068
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.98318116
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90608415
19	Sulfur metabolism_Homo sapiens_hsa00920	1.83022822
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.82399661
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.81022719
22	Fatty acid elongation_Homo sapiens_hsa00062	1.79959671
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.74873354
24	Sulfur relay system_Homo sapiens_hsa04122	1.73517393
25	Parkinsons disease_Homo sapiens_hsa05012	1.64162312
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.61600959
27	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.54872281
28	Proteasome_Homo sapiens_hsa03050	1.45708561
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.39599670
30	One carbon pool by folate_Homo sapiens_hsa00670	1.31925539
31	Viral myocarditis_Homo sapiens_hsa05416	1.31273051
32	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.31262624
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22987330
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.22204231
35	Huntingtons disease_Homo sapiens_hsa05016	1.12661263
36	Purine metabolism_Homo sapiens_hsa00230	1.11987584
37	Phototransduction_Homo sapiens_hsa04744	1.07708722
38	RNA degradation_Homo sapiens_hsa03018	1.06940082
39	Phenylalanine metabolism_Homo sapiens_hsa00360	1.05799401
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.03774927
41	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.01812322
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.01673241
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01305655
44	Folate biosynthesis_Homo sapiens_hsa00790	0.97998366
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95291651
46	Rheumatoid arthritis_Homo sapiens_hsa05323	0.95049913
47	Alzheimers disease_Homo sapiens_hsa05010	0.94910640
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91555635
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89242754
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.85296019
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.84646890
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82841930
53	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.78619698
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76883049
55	Viral carcinogenesis_Homo sapiens_hsa05203	0.75927016
56	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.75631002
57	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.73204765
58	Protein export_Homo sapiens_hsa03060	0.72908485
59	Butanoate metabolism_Homo sapiens_hsa00650	0.71145919
60	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.68276499
61	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.67023526
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.66967189
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66105781
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65986875
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64455918
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.63255627
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.61967561
68	Glutathione metabolism_Homo sapiens_hsa00480	0.61120025
69	Linoleic acid metabolism_Homo sapiens_hsa00591	0.60917869
70	Metabolic pathways_Homo sapiens_hsa01100	0.60732708
71	Peroxisome_Homo sapiens_hsa04146	0.60707686
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58778252
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.58317409
74	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.57821016
75	Spliceosome_Homo sapiens_hsa03040	0.56718405
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.55963864
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.53899507
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53036495
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52442328
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.50811891
81	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.50316266
82	Galactose metabolism_Homo sapiens_hsa00052	0.47299748
83	Herpes simplex infection_Homo sapiens_hsa05168	0.47245637
84	Leishmaniasis_Homo sapiens_hsa05140	0.46136289
85	Pentose phosphate pathway_Homo sapiens_hsa00030	0.45104941
86	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.43120503
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42620390
88	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.42179999
89	Cardiac muscle contraction_Homo sapiens_hsa04260	0.39436169
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.37714542
91	Lysine degradation_Homo sapiens_hsa00310	0.34531833
92	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.33556116
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31283922
94	Propanoate metabolism_Homo sapiens_hsa00640	0.29631816
95	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.28664854
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.27152853
97	Lysosome_Homo sapiens_hsa04142	0.26888511
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.25676464
99	Carbon metabolism_Homo sapiens_hsa01200	0.23618854
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.22784680

SLC7A5P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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