SLC7A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.33979337
2negative thymic T cell selection (GO:0045060)5.24045627
3negative T cell selection (GO:0043383)5.23424826
4thymic T cell selection (GO:0045061)4.75680162
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.68535678
6negative regulation of cell killing (GO:0031342)4.68535678
7positive thymic T cell selection (GO:0045059)4.60671864
8maturation of SSU-rRNA (GO:0030490)4.59553882
9DNA unwinding involved in DNA replication (GO:0006268)4.45038275
10positive T cell selection (GO:0043368)4.40526718
11response to interleukin-15 (GO:0070672)4.34610690
12T cell selection (GO:0045058)4.27995945
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26636138
14regulation of gamma-delta T cell differentiation (GO:0045586)4.25680973
15regulation of histone H3-K27 methylation (GO:0061085)4.18027059
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.15118894
17antigen processing and presentation of endogenous antigen (GO:0019883)4.03614070
18DNA strand elongation involved in DNA replication (GO:0006271)4.03128252
19ribosomal small subunit assembly (GO:0000028)3.96641886
20regulation of B cell receptor signaling pathway (GO:0050855)3.94707529
21translational termination (GO:0006415)3.93139330
22viral transcription (GO:0019083)3.92654911
23regulation of gamma-delta T cell activation (GO:0046643)3.92246916
24positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.89777104
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88455563
26positive regulation of granulocyte differentiation (GO:0030854)3.88312821
27formation of translation preinitiation complex (GO:0001731)3.86713484
28DNA replication initiation (GO:0006270)3.83671859
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80229255
30DNA strand elongation (GO:0022616)3.78561703
31nucleobase biosynthetic process (GO:0046112)3.74757770
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62806479
33B cell receptor signaling pathway (GO:0050853)3.61953773
34cellular response to interleukin-15 (GO:0071350)3.59237605
35translational initiation (GO:0006413)3.57308102
36purine nucleobase biosynthetic process (GO:0009113)3.56409008
37translational elongation (GO:0006414)3.53534675
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53321503
39ribosomal small subunit biogenesis (GO:0042274)3.52299301
40negative regulation of erythrocyte differentiation (GO:0045647)3.52192190
41tolerance induction (GO:0002507)3.52082439
42ribosomal large subunit biogenesis (GO:0042273)3.51479658
43telomere maintenance via semi-conservative replication (GO:0032201)3.49842251
44T cell migration (GO:0072678)3.45321207
45positive regulation of B cell differentiation (GO:0045579)3.42776018
46nuclear pore organization (GO:0006999)3.39397972
47ribosome assembly (GO:0042255)3.36632766
48mitotic nuclear envelope disassembly (GO:0007077)3.33067456
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31655622
50nuclear pore complex assembly (GO:0051292)3.25801158
51histone H3-K36 demethylation (GO:0070544)3.23896838
52peptidyl-arginine omega-N-methylation (GO:0035247)3.23062127
53negative regulation of RNA splicing (GO:0033119)3.22522295
54DNA replication checkpoint (GO:0000076)3.20969989
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20880119
56telomere maintenance via recombination (GO:0000722)3.19948746
57regulation of B cell differentiation (GO:0045577)3.18536278
58leukocyte aggregation (GO:0070486)3.17582140
59embryonic process involved in female pregnancy (GO:0060136)3.17230230
60cellular protein complex disassembly (GO:0043624)3.16349875
61mannose metabolic process (GO:0006013)3.13949348
62protein localization to kinetochore (GO:0034501)3.13879415
63regulation of regulatory T cell differentiation (GO:0045589)3.13773229
64mitotic recombination (GO:0006312)3.13257136
65membrane disassembly (GO:0030397)3.12553680
66nuclear envelope disassembly (GO:0051081)3.12553680
67ribonucleoprotein complex biogenesis (GO:0022613)3.12297821
68response to laminar fluid shear stress (GO:0034616)3.11698899
69cotranslational protein targeting to membrane (GO:0006613)3.09694412
70protein targeting to ER (GO:0045047)3.09411705
71regulation of isotype switching to IgG isotypes (GO:0048302)3.08180855
72viral life cycle (GO:0019058)3.06956120
73regulation of granulocyte differentiation (GO:0030852)3.04136838
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.01125343
75IMP biosynthetic process (GO:0006188)3.00744856
76protein complex disassembly (GO:0043241)3.00673955
77DNA replication-dependent nucleosome assembly (GO:0006335)2.99658701
78DNA replication-dependent nucleosome organization (GO:0034723)2.99658701
79negative regulation of T cell mediated immunity (GO:0002710)2.96933600
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96130595
81phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.95278020
82regulation of interleukin-2 biosynthetic process (GO:0045076)2.94653526
83establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94374297
84regulation of T cell tolerance induction (GO:0002664)2.94176147
85DNA deamination (GO:0045006)2.92966607
86ribosome biogenesis (GO:0042254)2.92339299
87regulation of alpha-beta T cell proliferation (GO:0046640)2.92083439
88telomere maintenance via telomere lengthening (GO:0010833)2.91325962
89spliceosomal snRNP assembly (GO:0000387)2.89221481
90protein localization to endoplasmic reticulum (GO:0070972)2.88942836
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88716000
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88394828
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87363549
94peptidyl-arginine N-methylation (GO:0035246)2.86711271
95peptidyl-arginine methylation (GO:0018216)2.86711271
96positive regulation of tolerance induction (GO:0002645)2.86702555
97negative regulation of mRNA processing (GO:0050686)2.85591480
98rRNA processing (GO:0006364)2.85464815
99positive regulation of isotype switching (GO:0045830)2.84711606
100RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84457483
101mRNA splicing, via spliceosome (GO:0000398)2.84457483
102macromolecular complex disassembly (GO:0032984)2.84250601
103histone arginine methylation (GO:0034969)2.83831450
104nuclear-transcribed mRNA catabolic process (GO:0000956)2.83085246
105RNA splicing, via transesterification reactions (GO:0000375)2.82977724
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82603133
107translesion synthesis (GO:0019985)2.80544685
108natural killer cell differentiation (GO:0001779)2.80035884
109regulation of RNA export from nucleus (GO:0046831)2.78216613
110rRNA metabolic process (GO:0016072)2.78206403
111antigen processing and presentation via MHC class Ib (GO:0002475)2.77697496
112response to muramyl dipeptide (GO:0032495)2.77646051
113positive regulation of alpha-beta T cell proliferation (GO:0046641)2.77643491
114regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75880480
115T cell homeostasis (GO:0043029)2.74473440
116mitotic metaphase plate congression (GO:0007080)2.72727590
117negative regulation of lymphocyte mediated immunity (GO:0002707)2.70823215
118negative regulation of ligase activity (GO:0051352)2.70719186
119negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70719186
120regulation of translational termination (GO:0006449)2.70340325
121antigen receptor-mediated signaling pathway (GO:0050851)2.70108377
122spliceosomal complex assembly (GO:0000245)2.69129447
123mitotic spindle assembly checkpoint (GO:0007094)2.68686430
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68437121
125negative regulation of sister chromatid segregation (GO:0033046)2.68437121
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.68437121
127negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68437121
128mRNA catabolic process (GO:0006402)2.68420414
129germinal center formation (GO:0002467)2.67416965
130negative regulation of chromosome segregation (GO:0051985)2.67196121
131T cell receptor signaling pathway (GO:0050852)2.66747550
132regulation of necroptotic process (GO:0060544)2.66568271
133DNA duplex unwinding (GO:0032508)2.66555760
134protein localization to chromosome, centromeric region (GO:0071459)2.64246000
135spindle assembly checkpoint (GO:0071173)2.63825860
136regulation of tolerance induction (GO:0002643)2.63676763
137pre-miRNA processing (GO:0031054)2.63649076
138RNA catabolic process (GO:0006401)2.63627837
139DNA geometric change (GO:0032392)2.63599445
140histone H3-K4 trimethylation (GO:0080182)2.62813712
141CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.62596436
142regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61731186
143regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.61679332
144cell-substrate adherens junction assembly (GO:0007045)2.60908394
145focal adhesion assembly (GO:0048041)2.60908394
146hepatocyte apoptotic process (GO:0097284)2.60559740
147translation (GO:0006412)2.60066070
148B cell homeostasis (GO:0001782)2.59668229
149interferon-gamma secretion (GO:0072643)2.59284923
150lung-associated mesenchyme development (GO:0060484)2.58380555
151negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.58363657
152nuclear envelope organization (GO:0006998)2.57670616
153mitotic spindle checkpoint (GO:0071174)2.56944725
154positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.56434889
155regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54840482
156regulation of nucleobase-containing compound transport (GO:0032239)2.54676298
157negative regulation of T-helper cell differentiation (GO:0045623)2.54539614
158negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.54539614
159IMP metabolic process (GO:0046040)2.54484702
160deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.53710203
161spindle checkpoint (GO:0031577)2.53442727
162DNA replication-independent nucleosome assembly (GO:0006336)2.53136582
163DNA replication-independent nucleosome organization (GO:0034724)2.53136582
164viral mRNA export from host cell nucleus (GO:0046784)2.52440034
165pore complex assembly (GO:0046931)2.51663631
166pinocytosis (GO:0006907)2.51257435
167histone H2A acetylation (GO:0043968)2.50931535
168CENP-A containing nucleosome assembly (GO:0034080)2.50757483
169B cell proliferation (GO:0042100)2.50636226
170Peyers patch development (GO:0048541)2.48652000
171mucosal-associated lymphoid tissue development (GO:0048537)2.48652000
172interferon-gamma production (GO:0032609)2.47501190
173regulation of natural killer cell mediated immunity (GO:0002715)2.46708619
174regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.46708619
175negative regulation of leukocyte mediated immunity (GO:0002704)2.45849005
176regulation of isotype switching (GO:0045191)2.42451329
177cellular extravasation (GO:0045123)2.40756413
178negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.40404785
179activated T cell proliferation (GO:0050798)2.40098011
180histone H3-K4 methylation (GO:0051568)2.39851175
181V(D)J recombination (GO:0033151)2.38253070
182low-density lipoprotein particle clearance (GO:0034383)2.38165940
183T cell costimulation (GO:0031295)2.37271133
184NIK/NF-kappaB signaling (GO:0038061)2.36382892
185cell-substrate junction assembly (GO:0007044)2.35142628
186lymphocyte homeostasis (GO:0002260)2.35081623
187lymphocyte costimulation (GO:0031294)2.34587237
188positive regulation of interleukin-2 production (GO:0032743)2.34192973
189negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.29884082
190positive regulation by symbiont of host defense response (GO:0052509)2.28754376
191modulation by symbiont of host defense response (GO:0052031)2.28754376
192modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.28754376
193modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.28754376
194positive regulation by organism of defense response of other organism involved in symbiotic interact2.28754376
195modulation by symbiont of host immune response (GO:0052553)2.28754376
196regulation of defense response to virus by virus (GO:0050690)2.28220679
197lymph node development (GO:0048535)2.27759239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26055094
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45380951
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.21064329
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.84500291
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.68132744
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62424694
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33523333
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.32447574
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.01448906
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.00169254
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86235265
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.75904647
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75370911
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74769665
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.72560465
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70695949
17XRN2_22483619_ChIP-Seq_HELA_Human2.64597889
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.62110785
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.57826065
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49734458
21MAF_26560356_Chip-Seq_TH1_Human2.49270265
22RUNX_20019798_ChIP-Seq_JUKART_Human2.45827578
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45719489
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43026540
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38519356
26TCF7_22412390_ChIP-Seq_EML_Mouse2.28147176
27MYB_26560356_Chip-Seq_TH2_Human2.23868848
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21439224
29MYB_26560356_Chip-Seq_TH1_Human2.18009576
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17706522
31CIITA_25753668_ChIP-Seq_RAJI_Human2.16213226
32MYC_22102868_ChIP-Seq_BL_Human2.14391905
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13513676
34UTX_26944678_Chip-Seq_JUKART_Human2.12953028
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12814387
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09422017
37* VDR_23849224_ChIP-Seq_CD4+_Human2.06628708
38KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01981256
39* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01317738
40ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00362741
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99977295
42MAF_26560356_Chip-Seq_TH2_Human1.99948823
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99076482
44TTF2_22483619_ChIP-Seq_HELA_Human1.98734418
45AR_21909140_ChIP-Seq_LNCAP_Human1.94402435
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.94230108
47* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93798472
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92730103
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89201154
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.88953118
51FOXP3_21729870_ChIP-Seq_TREG_Human1.88177246
52VDR_24763502_ChIP-Seq_THP-1_Human1.86646638
53KDM2B_26808549_Chip-Seq_DND41_Human1.85278123
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85094307
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.84936592
56* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83886847
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83113567
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.82305008
59DCP1A_22483619_ChIP-Seq_HELA_Human1.81388802
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80482396
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80160178
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79318921
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78982831
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78842588
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73045077
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72900137
67GABP_19822575_ChIP-Seq_HepG2_Human1.70695306
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69686354
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67793824
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60796953
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58380496
72ELK1_19687146_ChIP-ChIP_HELA_Human1.58244417
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.57242649
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55955075
75SPI1_23547873_ChIP-Seq_NB4_Human1.55202777
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54473055
77* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52063221
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48538688
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48363681
80SCL_19346495_ChIP-Seq_HPC-7_Human1.46463878
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.46061543
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44954947
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42584011
84SPI1_23127762_ChIP-Seq_K562_Human1.42238652
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40972889
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38156401
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38095946
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37903838
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37826359
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37196968
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36923412
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35723488
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35457259
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34640601
95* GATA3_27048872_Chip-Seq_THYMUS_Human1.34479073
96IRF8_27001747_Chip-Seq_BMDM_Mouse1.31795478
97KDM5A_27292631_Chip-Seq_BREAST_Human1.31755418
98GATA1_22025678_ChIP-Seq_K562_Human1.31400024
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31148405
100* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30855808
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30532243
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.29844130
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29202161
104NCOR1_26117541_ChIP-Seq_K562_Human1.27529609
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25466698
106RACK7_27058665_Chip-Seq_MCF-7_Human1.25158837
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24717804
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24473250
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23891511
110VDR_21846776_ChIP-Seq_THP-1_Human1.23393556
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22581865
112ELK1_22589737_ChIP-Seq_MCF10A_Human1.21261422
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20926488
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18653713
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17944960
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17910617
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17341595
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16724537
119LXR_22292898_ChIP-Seq_THP-1_Human1.16011447
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15941892
121* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15087478
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14861410
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14034525
124SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12849177
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12273122
126* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10974795
127IRF8_21731497_ChIP-ChIP_J774_Mouse1.10741238
128STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09835993
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09827360
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07168422
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07154375
132PU_27001747_Chip-Seq_BMDM_Mouse1.06875022
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06369787
134NOTCH1_21737748_ChIP-Seq_TLL_Human1.04820043
135TFEB_21752829_ChIP-Seq_HELA_Human1.04607251
136PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04028620
137* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01222898
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00096028
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.99094826
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98824152
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98655564
142* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97726936
143* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97125010
144SMAD_19615063_ChIP-ChIP_OVARY_Human0.96570209
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96156667
146NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95916034
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95536222
148ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95525184
149ZNF263_19887448_ChIP-Seq_K562_Human0.95168011
150* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94535975
151* CLOCK_20551151_ChIP-Seq_293T_Human0.94297625
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91628271
153PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91396426
154GATA1_19941826_ChIP-Seq_K562_Human0.91374762
155* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91159891
156RUNX1_27514584_Chip-Seq_MCF-7_Human0.90644182
157* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90485931
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90210463
159GATA2_21666600_ChIP-Seq_HMVEC_Human0.89258457
160HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88275219
161* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87299957
162STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85424601
163SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85129740
164NANOG_21062744_ChIP-ChIP_HESCs_Human0.85019593
165RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84668628
166TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84062293
167FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83705032
168FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82990760
169HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81483872
170EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81473450
171CHD1_26751641_Chip-Seq_LNCaP_Human0.81340663
172HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79651304
173* ATF3_27146783_Chip-Seq_COLON_Human0.78876436
174ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78084995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.86878552
2MP0003111_abnormal_nucleus_morphology3.35560593
3MP0004957_abnormal_blastocyst_morpholog3.34198734
4MP0010094_abnormal_chromosome_stability3.19535266
5MP0008057_abnormal_DNA_replication3.08414307
6MP0003077_abnormal_cell_cycle3.00145079
7MP0010030_abnormal_orbit_morphology2.87678489
8MP0003436_decreased_susceptibility_to2.67319403
9MP0001835_abnormal_antigen_presentation2.66074159
10MP0008932_abnormal_embryonic_tissue2.53249145
11MP0003300_gastrointestinal_ulcer2.49829147
12MP0008007_abnormal_cellular_replicative2.48765226
13MP0008058_abnormal_DNA_repair2.40145424
14MP0000537_abnormal_urethra_morphology2.34842531
15MP0000685_abnormal_immune_system2.28768587
16MP0001800_abnormal_humoral_immune2.25682831
17MP0010352_gastrointestinal_tract_polyps2.21283247
18MP0001873_stomach_inflammation2.11446284
19MP0002166_altered_tumor_susceptibility2.09871650
20MP0009333_abnormal_splenocyte_physiolog2.04494118
21MP0005671_abnormal_response_to1.95352605
22MP0000350_abnormal_cell_proliferation1.94302349
23MP0001730_embryonic_growth_arrest1.93996279
24MP0002398_abnormal_bone_marrow1.93809242
25MP0004381_abnormal_hair_follicle1.93311269
26MP0003123_paternal_imprinting1.91955997
27MP0004185_abnormal_adipocyte_glucose1.91369681
28MP0001790_abnormal_immune_system1.89797544
29MP0005387_immune_system_phenotype1.89797544
30MP0005451_abnormal_body_composition1.87586069
31MP0005000_abnormal_immune_tolerance1.85339301
32MP0001348_abnormal_lacrimal_gland1.82871575
33MP0002405_respiratory_system_inflammati1.80323905
34MP0002420_abnormal_adaptive_immunity1.78321347
35MP0001819_abnormal_immune_cell1.74373480
36MP0002723_abnormal_immune_serum1.71571188
37MP0002396_abnormal_hematopoietic_system1.68062609
38MP0002102_abnormal_ear_morphology1.65617557
39MP0004947_skin_inflammation1.65310170
40MP0002452_abnormal_antigen_presenting1.64521672
41MP0000566_synostosis1.62424849
42MP0003091_abnormal_cell_migration1.62203520
43MP0003567_abnormal_fetal_cardiomyocyte1.62112123
44MP0001697_abnormal_embryo_size1.60907177
45MP0002722_abnormal_immune_system1.60186922
46MP0000716_abnormal_immune_system1.59428400
47MP0002084_abnormal_developmental_patter1.59364980
48MP0005076_abnormal_cell_differentiation1.57088333
49MP0005380_embryogenesis_phenotype1.53588981
50MP0001672_abnormal_embryogenesis/_devel1.53588981
51MP0000689_abnormal_spleen_morphology1.52607380
52MP0002085_abnormal_embryonic_tissue1.52489405
53MP0000428_abnormal_craniofacial_morphol1.48470289
54MP0005025_abnormal_response_to1.48450179
55MP0003191_abnormal_cellular_cholesterol1.48445556
56MP0004197_abnormal_fetal_growth/weight/1.48193274
57MP0003786_premature_aging1.44095283
58MP0003984_embryonic_growth_retardation1.44078000
59MP0003283_abnormal_digestive_organ1.43636677
60MP0001853_heart_inflammation1.43341401
61MP0003315_abnormal_perineum_morphology1.42532982
62MP0002088_abnormal_embryonic_growth/wei1.42531631
63MP0002006_tumorigenesis1.39350618
64MP0002429_abnormal_blood_cell1.39337054
65MP0000858_altered_metastatic_potential1.38514467
66MP0003937_abnormal_limbs/digits/tail_de1.37791054
67MP0002419_abnormal_innate_immunity1.37694535
68MP0005666_abnormal_adipose_tissue1.36305181
69MP0005409_darkened_coat_color1.35970390
70MP0002080_prenatal_lethality1.35939955
71MP0003941_abnormal_skin_development1.35239754
72MP0004808_abnormal_hematopoietic_stem1.35111565
73MP0009053_abnormal_anal_canal1.35109380
74MP0010155_abnormal_intestine_physiology1.34854487
75MP0003119_abnormal_digestive_system1.32505249
76MP0008438_abnormal_cutaneous_collagen1.30508597
77MP0003115_abnormal_respiratory_system1.28993233
78MP0001293_anophthalmia1.28031982
79MP0003303_peritoneal_inflammation1.27577079
80MP0000490_abnormal_crypts_of1.26795977
81MP0004133_heterotaxia1.26744725
82MP0002751_abnormal_autonomic_nervous1.25891137
83MP0003763_abnormal_thymus_physiology1.25628941
84MP0008260_abnormal_autophagy1.24886262
85MP0003828_pulmonary_edema1.24782992
86MP0004130_abnormal_muscle_cell1.24491839
87MP0002933_joint_inflammation1.22631017
88MP0002234_abnormal_pharynx_morphology1.20874687
89MP0002877_abnormal_melanocyte_morpholog1.20434027
90MP0009840_abnormal_foam_cell1.19101725
91MP0000383_abnormal_hair_follicle1.17818614
92MP0002086_abnormal_extraembryonic_tissu1.17379961
93MP0003890_abnormal_embryonic-extraembry1.15475871
94MP0005375_adipose_tissue_phenotype1.15227422
95MP0005464_abnormal_platelet_physiology1.14823832
96MP0003866_abnormal_defecation1.13591165
97MP0003172_abnormal_lysosome_physiology1.12357842
98MP0000465_gastrointestinal_hemorrhage1.10861674
99MP0002111_abnormal_tail_morphology1.10810942
100MP0010307_abnormal_tumor_latency1.09504833
101MP0001661_extended_life_span1.08125902
102MP0003279_aneurysm1.06634649
103MP0000313_abnormal_cell_death1.05874570
104MP0004233_abnormal_muscle_weight1.05693795
105MP0001851_eye_inflammation1.05608896
106MP0008877_abnormal_DNA_methylation1.05553388
107MP0003121_genomic_imprinting1.05415976
108MP0003724_increased_susceptibility_to1.04158989
109MP0009785_altered_susceptibility_to1.03963066
110MP0003566_abnormal_cell_adhesion1.03228801
111MP0000003_abnormal_adipose_tissue1.03130640
112MP0009115_abnormal_fat_cell1.01783604
113MP0000049_abnormal_middle_ear1.01109769
114MP0002092_abnormal_eye_morphology1.00785779
115MP0002282_abnormal_trachea_morphology0.99243242
116MP0001533_abnormal_skeleton_physiology0.98737801
117MP0002932_abnormal_joint_morphology0.97856324
118MP0005023_abnormal_wound_healing0.97724604
119MP0001958_emphysema0.97453453
120MP0002089_abnormal_postnatal_growth/wei0.96757560
121MP0003935_abnormal_craniofacial_develop0.96727940
122MP0000703_abnormal_thymus_morphology0.96556910
123MP0002970_abnormal_white_adipose0.94708585
124MP0003755_abnormal_palate_morphology0.93621171
125MP0002019_abnormal_tumor_incidence0.93022476
126MP0003045_fibrosis0.92852607
127MP0005670_abnormal_white_adipose0.92038052
128MP0006138_congestive_heart_failure0.91978335
129MP0003938_abnormal_ear_development0.91636194
130MP0003942_abnormal_urinary_system0.91520639
131MP0001845_abnormal_inflammatory_respons0.90839926
132MP0001286_abnormal_eye_development0.89449192
133MP0004264_abnormal_extraembryonic_tissu0.88826371
134MP0005058_abnormal_lysosome_morphology0.88101798
135MP0008789_abnormal_olfactory_epithelium0.87112379
136MP0002009_preneoplasia0.86364129
137MP0002697_abnormal_eye_size0.85918075
138MP0002998_abnormal_bone_remodeling0.85529466
139MP0005623_abnormal_meninges_morphology0.85191982
140MP0001915_intracranial_hemorrhage0.84975196
141MP0000767_abnormal_smooth_muscle0.84958994
142MP0008961_abnormal_basal_metabolism0.84754375
143MP0005275_abnormal_skin_tensile0.84704910
144MP0003861_abnormal_nervous_system0.84407715
145MP0000432_abnormal_head_morphology0.84348766
146MP0006054_spinal_hemorrhage0.83230475
147MP0003705_abnormal_hypodermis_morpholog0.82964501
148MP0010630_abnormal_cardiac_muscle0.81632083
149MP0000358_abnormal_cell_content/0.81580663
150MP0001849_ear_inflammation0.81375794
151MP0005257_abnormal_intraocular_pressure0.81242359
152MP0003221_abnormal_cardiomyocyte_apopto0.80493415
153MP0000569_abnormal_digit_pigmentation0.80136905
154MP0003959_abnormal_lean_body0.79758303
155MP0002148_abnormal_hypersensitivity_rea0.79695404
156MP0002233_abnormal_nose_morphology0.79346833
157MP0000647_abnormal_sebaceous_gland0.79086077
158MP0003448_altered_tumor_morphology0.79067255
159MP0002160_abnormal_reproductive_system0.77854070
160MP0000733_abnormal_muscle_development0.77825107
161MP0005508_abnormal_skeleton_morphology0.77606907
162MP0002971_abnormal_brown_adipose0.77302688
163MP0000759_abnormal_skeletal_muscle0.76544229
164MP0002060_abnormal_skin_morphology0.76395081
165MP0002210_abnormal_sex_determination0.75619898
166MP0000534_abnormal_ureter_morphology0.75575819
167MP0002116_abnormal_craniofacial_bone0.75397029
168MP0002114_abnormal_axial_skeleton0.74202689
169MP0005501_abnormal_skin_physiology0.74155201
170MP0009672_abnormal_birth_weight0.72761467
171MP0010678_abnormal_skin_adnexa0.72521408
172MP0001299_abnormal_eye_distance/0.71445023
173MP0005384_cellular_phenotype0.70064685
174MP0001145_abnormal_male_reproductive0.67909546
175MP0003718_maternal_effect0.67377251
176MP0002938_white_spotting0.67232741
177MP0000627_abnormal_mammary_gland0.66851562
178MP0005621_abnormal_cell_physiology0.66133542
179MP0000762_abnormal_tongue_morphology0.65537857

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.11103883
2Reticulocytopenia (HP:0001896)3.87986850
3Abnormality of T cell number (HP:0011839)3.62061015
4Eczematoid dermatitis (HP:0000976)3.28023487
5Recurrent viral infections (HP:0004429)3.26107918
6Panhypogammaglobulinemia (HP:0003139)3.17169970
7Abnormality of the fingertips (HP:0001211)3.14483906
8Pustule (HP:0200039)3.10371440
9Selective tooth agenesis (HP:0001592)3.07123952
10Colitis (HP:0002583)3.06274335
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.02537148
12Recurrent fungal infections (HP:0002841)2.89924405
13Pelvic girdle muscle weakness (HP:0003749)2.85892506
14Spinal cord lesions (HP:0100561)2.84036089
15Syringomyelia (HP:0003396)2.84036089
16Colon cancer (HP:0003003)2.80887233
17Birth length less than 3rd percentile (HP:0003561)2.80760433
18Shoulder girdle muscle weakness (HP:0003547)2.80189575
19Carpal bone hypoplasia (HP:0001498)2.76960617
20Abnormality of T cells (HP:0002843)2.75781582
21Dislocated radial head (HP:0003083)2.72777792
22Abnormality of cells of the erythroid lineage (HP:0012130)2.71921556
23Recurrent cutaneous fungal infections (HP:0011370)2.71046898
24Chronic mucocutaneous candidiasis (HP:0002728)2.71046898
25Breast hypoplasia (HP:0003187)2.65458077
26Gastrointestinal inflammation (HP:0004386)2.60368646
27Degeneration of anterior horn cells (HP:0002398)2.56636037
28Abnormality of the anterior horn cell (HP:0006802)2.56636037
2911 pairs of ribs (HP:0000878)2.56009396
30Severe combined immunodeficiency (HP:0004430)2.52951163
31Autoimmune hemolytic anemia (HP:0001890)2.51127467
32Inflammation of the large intestine (HP:0002037)2.50678966
33Abnormality of the radial head (HP:0003995)2.49696895
34Patellar aplasia (HP:0006443)2.48371194
35Rough bone trabeculation (HP:0100670)2.48171797
36Broad face (HP:0000283)2.45659822
37Agammaglobulinemia (HP:0004432)2.43381398
38Proximal placement of thumb (HP:0009623)2.43125580
39Abnormal number of incisors (HP:0011064)2.42920142
40Abnormality of oral frenula (HP:0000190)2.42524880
41Deviation of the thumb (HP:0009603)2.39779809
42Abnormal number of erythroid precursors (HP:0012131)2.39640771
43Neoplasm of the pancreas (HP:0002894)2.39589657
44Abnormality of the musculature of the pelvis (HP:0001469)2.38288954
45Abnormality of the hip-girdle musculature (HP:0001445)2.38288954
46Aplasia/Hypoplasia of the patella (HP:0006498)2.36734979
47Cellulitis (HP:0100658)2.34161494
48Absent radius (HP:0003974)2.33734131
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32879885
50Ependymoma (HP:0002888)2.32691461
51Verrucae (HP:0200043)2.28961275
52Papilloma (HP:0012740)2.28961275
53Medulloblastoma (HP:0002885)2.27151046
54Trismus (HP:0000211)2.25787272
55Chromsome breakage (HP:0040012)2.23890054
56Flat acetabular roof (HP:0003180)2.22449032
57Meningitis (HP:0001287)2.21826619
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21773697
59Short 4th metacarpal (HP:0010044)2.21773697
60Absent forearm bone (HP:0003953)2.21173952
61Aplasia involving forearm bones (HP:0009822)2.21173952
62Recurrent bacterial skin infections (HP:0005406)2.20928161
63Recurrent bronchitis (HP:0002837)2.19870217
64Increased nuchal translucency (HP:0010880)2.19725074
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.17201912
66Peritonitis (HP:0002586)2.16832402
67Ankyloglossia (HP:0010296)2.16477759
68Viral hepatitis (HP:0006562)2.15104699
69Hypoplasia of the thymus (HP:0000778)2.14597032
70Granulocytopenia (HP:0001913)2.14027991
71Abnormality of the common coagulation pathway (HP:0010990)2.13516657
72Recurrent abscess formation (HP:0002722)2.13251807
73Fatigue (HP:0012378)2.12453062
74Protrusio acetabuli (HP:0003179)2.11467179
75Abnormality of T cell physiology (HP:0011840)2.11242354
76Lymphopenia (HP:0001888)2.11089501
77Slow saccadic eye movements (HP:0000514)2.09510272
78Gastrointestinal stroma tumor (HP:0100723)2.09387685
79Recurrent skin infections (HP:0001581)2.07418825
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.07334232
81Gastrointestinal infarctions (HP:0005244)2.06467786
82Abnormality of macrophages (HP:0004311)2.05872700
83Atresia of the external auditory canal (HP:0000413)2.05523642
84Meckel diverticulum (HP:0002245)2.05518106
85Spondylolisthesis (HP:0003302)2.04497980
86Increased IgE level (HP:0003212)2.04381429
87Sparse lateral eyebrow (HP:0005338)2.03981701
88Pallor (HP:0000980)2.03537663
89Subacute progressive viral hepatitis (HP:0006572)2.01489977
90IgG deficiency (HP:0004315)2.01252795
91Macrocytic anemia (HP:0001972)2.01204368
92Myositis (HP:0100614)2.00748315
93Elevated erythrocyte sedimentation rate (HP:0003565)2.00512456
94Dilatation of the ascending aorta (HP:0005111)2.00042435
95Abnormality of the preputium (HP:0100587)1.97814968
96Abnormality of the ileum (HP:0001549)1.97501396
97IgA deficiency (HP:0002720)1.96889834
98Combined immunodeficiency (HP:0005387)1.96877953
99Spontaneous hematomas (HP:0007420)1.96564341
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95979980
101Oral leukoplakia (HP:0002745)1.95979226
102Heterotopia (HP:0002282)1.94974352
103Abnormality of the calcaneus (HP:0008364)1.94613330
104Prolonged bleeding time (HP:0003010)1.94463773
105Duodenal stenosis (HP:0100867)1.91848265
106Small intestinal stenosis (HP:0012848)1.91848265
107Long eyelashes (HP:0000527)1.91554770
108Ectopic kidney (HP:0000086)1.91457374
109Aortic aneurysm (HP:0004942)1.90728893
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90662969
111High anterior hairline (HP:0009890)1.90500984
112Exercise-induced myalgia (HP:0003738)1.90497722
113Premature rupture of membranes (HP:0001788)1.90132140
114Entropion (HP:0000621)1.88279970
115Centrally nucleated skeletal muscle fibers (HP:0003687)1.87734304
116Epistaxis (HP:0000421)1.86894021
117Abnormality of the umbilical cord (HP:0010881)1.86374136
118Aplastic anemia (HP:0001915)1.86262787
119Disproportionate tall stature (HP:0001519)1.85773929
120Horseshoe kidney (HP:0000085)1.85713573
121Dysmetric saccades (HP:0000641)1.85637362
122Missing ribs (HP:0000921)1.85482218
123Renal duplication (HP:0000075)1.84781258
124Absent thumb (HP:0009777)1.84618621
125Chronic diarrhea (HP:0002028)1.84364845
126Seborrheic dermatitis (HP:0001051)1.83960391
127Lymphoma (HP:0002665)1.83084058
128Cerebral aneurysm (HP:0004944)1.82925428
129Vasculitis (HP:0002633)1.82884087
130Increased variability in muscle fiber diameter (HP:0003557)1.82489695
131Abnormality of skeletal muscle fiber size (HP:0012084)1.82172733
132Aneurysm (HP:0002617)1.82073980
133Glucose intolerance (HP:0000833)1.81924818
134Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.81103923
135Arterial tortuosity (HP:0005116)1.80877399
136Persistence of primary teeth (HP:0006335)1.79485211
137Glossoptosis (HP:0000162)1.79219324
138Acute hepatic failure (HP:0006554)1.79176944
139Osteolytic defects of the hand bones (HP:0009699)1.78503762
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.78503762
141Hyperacusis (HP:0010780)1.76605017
142Mediastinal lymphadenopathy (HP:0100721)1.75806970
143Vascular tortuosity (HP:0004948)1.75770059
144Abnormality of the peritoneum (HP:0002585)1.75517359
145Triphalangeal thumb (HP:0001199)1.75383241
146Abnormal trabecular bone morphology (HP:0100671)1.75206718
147Emphysema (HP:0002097)1.74967583
148Chest pain (HP:0100749)1.74884811
149Increased density of long bones (HP:0006392)1.74658467
150Hepatitis (HP:0012115)1.74636661
151Microretrognathia (HP:0000308)1.74186126
152Progressive muscle weakness (HP:0003323)1.74087429
153Optic nerve coloboma (HP:0000588)1.73673385
154Gingival bleeding (HP:0000225)1.73069204
155Esophageal atresia (HP:0002032)1.72552854
156Cerebral hypomyelination (HP:0006808)1.72165651
157Abnormality of abdominal situs (HP:0011620)1.71553059
158Abdominal situs inversus (HP:0003363)1.71553059
159Atrophy/Degeneration involving motor neurons (HP:0007373)1.71140175
160Narrow palate (HP:0000189)1.70577562
161Broad palm (HP:0001169)1.70442472
162Congenital, generalized hypertrichosis (HP:0004540)1.69569746
163Hemorrhage of the eye (HP:0011885)1.68869680
164Thin bony cortex (HP:0002753)1.68747105
165Coarse hair (HP:0002208)1.68672532
166Easy fatigability (HP:0003388)1.67852352
167Aplasia/Hypoplasia of the spleen (HP:0010451)1.67700365
168Basal cell carcinoma (HP:0002671)1.67241422
169Short thumb (HP:0009778)1.66743131
170Abnormality of the duodenum (HP:0002246)1.66404867
171Megalocornea (HP:0000485)1.66006404
172Tracheoesophageal fistula (HP:0002575)1.65745670
173Abnormality of chromosome stability (HP:0003220)1.64539740
174Astrocytoma (HP:0009592)1.64329868
175Abnormality of the astrocytes (HP:0100707)1.64329868
176Glioma (HP:0009733)1.64018932
177Choanal atresia (HP:0000453)1.63429344
178Bowel diverticulosis (HP:0005222)1.63045065
179Abnormal lung lobation (HP:0002101)1.61035743
180Abnormality of the carotid arteries (HP:0005344)1.59734363
181Myelodysplasia (HP:0002863)1.59647241
182Overlapping toe (HP:0001845)1.58641785
183Squamous cell carcinoma (HP:0002860)1.57376408
184Ankle contracture (HP:0006466)1.57192443
185Down-sloping shoulders (HP:0200021)1.56951392
186Aplasia/hypoplasia of the humerus (HP:0006507)1.56586181
187Shallow orbits (HP:0000586)1.56190215
188Prominent nose (HP:0000448)1.56044752
189Overriding aorta (HP:0002623)1.54380626
190Preauricular skin tag (HP:0000384)1.54110081
191Pancreatic cysts (HP:0001737)1.54109757
192Wrist flexion contracture (HP:0001239)1.53777882
193Slender long bone (HP:0003100)1.52630580
194Ureteral duplication (HP:0000073)1.52538774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.75554265
2WEE13.67880725
3PRPF4B3.22540864
4CDC73.16116452
5SRPK12.82352611
6EPHA22.66338139
7ERN12.54884304
8TSSK62.49344249
9TESK22.45990710
10MAP3K132.40946731
11CDK122.40394576
12FGFR42.39557117
13NEK22.32027167
14PASK2.30110214
15SMG12.28015038
16DYRK32.23058518
17TLK12.08518075
18MKNK12.04489167
19RIPK42.04351803
20TESK12.03217942
21MAP3K142.02670941
22ICK1.99411453
23TYK21.98816924
24EEF2K1.95427797
25RPS6KB21.94383519
26TXK1.94024706
27RPS6KA41.91947464
28TAOK21.90209437
29NME21.89494935
30MAP2K31.69682474
31ITK1.69589269
32SIK31.69000717
33FGFR31.68408281
34MAP3K111.67618747
35EIF2AK11.59531314
36PLK11.54702150
37NEK11.52461765
38PLK31.50470281
39CDK71.50172072
40SIK11.49892795
41JAK31.47058766
42JAK11.44786138
43AURKB1.42850852
44STK161.42673120
45PLK41.41544875
46BRSK21.40302844
47TTK1.40282457
48EPHB21.35827148
49TGFBR11.35479786
50PAK41.34638239
51ATR1.33462721
52CDK41.31646302
53MAP3K81.30499439
54BRSK11.27038858
55CSK1.26736815
56GRK61.25869728
57MAPK111.23627239
58IRAK41.19915814
59KSR11.16506000
60AURKA1.16338664
61MAP3K101.15330290
62EIF2AK31.14488620
63NEK91.12241062
64HCK1.11569073
65KSR21.10379708
66LIMK11.09281226
67BCR1.09170719
68MAP3K71.08842265
69BLK1.07752778
70NLK1.05956553
71CHEK21.04790358
72IKBKE1.04410995
73SIK21.03707288
74ACVR1B1.03243601
75EPHB11.03163249
76CDC42BPA1.01912017
77LCK1.00926354
78CHEK11.00656492
79SYK0.99742776
80VRK10.98017179
81PIK3CG0.96939882
82MELK0.96402710
83FGFR10.95819791
84BRD40.94513842
85TEC0.92742737
86MTOR0.91309771
87TRPM70.90687347
88MAPKAPK30.89733371
89NME10.89576138
90LRRK20.89272053
91TTN0.88339191
92CAMKK10.87504594
93MKNK20.86645584
94STK100.85373605
95FES0.84645641
96RIPK10.84295010
97MAPK120.83582659
98CAMKK20.82470483
99TBK10.82025122
100PIM20.81326403
101MARK30.75965444
102ZAK0.75599253
103CDK20.73992294
104PDK10.73612377
105PNCK0.72231151
106TRIB30.72220677
107MAP3K10.71996095
108PDGFRB0.71640021
109RPS6KA50.71560147
110MAP3K20.69142400
111MARK20.69101624
112TYRO30.68534678
113PTK60.67974521
114PDPK10.66148992
115WNK10.64336269
116PAK20.64088881
117JAK20.63766768
118PAK10.62436170
119CSF1R0.61721921
120YES10.61414309
121CDK10.61328325
122STK380.61195320
123MAP3K30.61105098
124TGFBR20.60259965
125RAF10.58370217
126RET0.58201351
127AKT20.56282304
128STK40.56244697
129ATM0.56072806
130LYN0.54826003
131CSNK2A20.54202420
132CLK10.53693642
133PRKAA20.53590569
134CCNB10.53077857
135NUAK10.52997487
136ALK0.51873828
137HIPK20.51167168
138IRAK30.50778970
139UHMK10.49884685
140LATS20.49196541
141MAP3K60.47117552
142CDK60.46993212
143DYRK20.46598434
144NEK60.45857441
145IKBKB0.45156104
146SGK30.44908549
147MAPK70.44683834
148ERBB30.43975144
149MST1R0.43246167
150CDK80.42496450
151ILK0.42164729
152KDR0.41683893
153PRKCI0.41098978
154CSNK1E0.41005382
155CSNK2A10.40658763
156CAMK1D0.39953567
157ZAP700.39367176
158SCYL20.39211270
159BTK0.38864664
160PKN20.38767867
161MAP2K20.37894342
162RPS6KC10.37887659
163PIM10.33913952
164MAPK90.33650419
165MAP4K10.33542067
166PDGFRA0.32304284
167STK30.31382461
168PDK40.31263656
169PDK30.31263656
170CHUK0.30404527
171MAPKAPK20.29503954
172CDK180.28360868
173DDR20.27868454

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.01728230
2Ribosome_Homo sapiens_hsa030103.29388845
3Spliceosome_Homo sapiens_hsa030403.22879782
4Mismatch repair_Homo sapiens_hsa034303.18051066
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09251909
6Proteasome_Homo sapiens_hsa030502.96905325
7RNA transport_Homo sapiens_hsa030132.95763210
8Base excision repair_Homo sapiens_hsa034102.65766360
9RNA polymerase_Homo sapiens_hsa030202.58143569
10Cell cycle_Homo sapiens_hsa041102.56370891
11Nucleotide excision repair_Homo sapiens_hsa034202.39592424
12B cell receptor signaling pathway_Homo sapiens_hsa046622.33918927
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11407625
14Homologous recombination_Homo sapiens_hsa034402.06327702
15Pyrimidine metabolism_Homo sapiens_hsa002401.97638566
16mRNA surveillance pathway_Homo sapiens_hsa030151.80215588
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76568226
18Fanconi anemia pathway_Homo sapiens_hsa034601.67730675
19Other glycan degradation_Homo sapiens_hsa005111.67125717
20p53 signaling pathway_Homo sapiens_hsa041151.65560137
21One carbon pool by folate_Homo sapiens_hsa006701.58547053
22Osteoclast differentiation_Homo sapiens_hsa043801.58172224
23Basal cell carcinoma_Homo sapiens_hsa052171.57534689
24RNA degradation_Homo sapiens_hsa030181.56151420
25Autoimmune thyroid disease_Homo sapiens_hsa053201.48473233
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.45408662
27Allograft rejection_Homo sapiens_hsa053301.44117651
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38457429
29Graft-versus-host disease_Homo sapiens_hsa053321.38320378
30Leishmaniasis_Homo sapiens_hsa051401.34230652
31Basal transcription factors_Homo sapiens_hsa030221.32666624
32Epstein-Barr virus infection_Homo sapiens_hsa051691.31224922
33VEGF signaling pathway_Homo sapiens_hsa043701.30290848
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29980588
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27905907
36Hippo signaling pathway_Homo sapiens_hsa043901.26369277
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25843663
38Hedgehog signaling pathway_Homo sapiens_hsa043401.24960480
39HTLV-I infection_Homo sapiens_hsa051661.24536548
40Non-homologous end-joining_Homo sapiens_hsa034501.24532131
41Influenza A_Homo sapiens_hsa051641.20099781
42Oocyte meiosis_Homo sapiens_hsa041141.15859102
43Inositol phosphate metabolism_Homo sapiens_hsa005621.14997613
44Small cell lung cancer_Homo sapiens_hsa052221.13141990
45TNF signaling pathway_Homo sapiens_hsa046681.12956941
46Viral carcinogenesis_Homo sapiens_hsa052031.10572787
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10354203
48Platelet activation_Homo sapiens_hsa046111.08318364
49Purine metabolism_Homo sapiens_hsa002301.06127611
50MicroRNAs in cancer_Homo sapiens_hsa052061.05640107
51Prolactin signaling pathway_Homo sapiens_hsa049171.04541452
52Antigen processing and presentation_Homo sapiens_hsa046121.03576598
53FoxO signaling pathway_Homo sapiens_hsa040681.02437716
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01515901
55Hepatitis C_Homo sapiens_hsa051601.00698070
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.97321061
57Insulin resistance_Homo sapiens_hsa049310.97140062
58N-Glycan biosynthesis_Homo sapiens_hsa005100.97100995
59Systemic lupus erythematosus_Homo sapiens_hsa053220.96216341
60Choline metabolism in cancer_Homo sapiens_hsa052310.93709605
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92343937
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90402282
63Glioma_Homo sapiens_hsa052140.87729301
64Insulin signaling pathway_Homo sapiens_hsa049100.86877152
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85346668
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84472521
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.83457272
68Chemokine signaling pathway_Homo sapiens_hsa040620.82997990
69ErbB signaling pathway_Homo sapiens_hsa040120.81718931
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80801108
71Notch signaling pathway_Homo sapiens_hsa043300.80308214
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80202158
73Type I diabetes mellitus_Homo sapiens_hsa049400.78854501
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.77892177
75Colorectal cancer_Homo sapiens_hsa052100.77734070
76Shigellosis_Homo sapiens_hsa051310.77307253
77Herpes simplex infection_Homo sapiens_hsa051680.77202054
78Viral myocarditis_Homo sapiens_hsa054160.74812968
79Tuberculosis_Homo sapiens_hsa051520.73882388
80GnRH signaling pathway_Homo sapiens_hsa049120.73319666
81Lysine degradation_Homo sapiens_hsa003100.73156218
82Thyroid cancer_Homo sapiens_hsa052160.72839593
83Chronic myeloid leukemia_Homo sapiens_hsa052200.72395044
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72035911
85Wnt signaling pathway_Homo sapiens_hsa043100.71083794
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69718785
87Proteoglycans in cancer_Homo sapiens_hsa052050.69313972
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68262973
89Pathways in cancer_Homo sapiens_hsa052000.67548153
90Apoptosis_Homo sapiens_hsa042100.67066338
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66777588
92Bladder cancer_Homo sapiens_hsa052190.66254482
93Legionellosis_Homo sapiens_hsa051340.65847706
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64755183
95Primary immunodeficiency_Homo sapiens_hsa053400.64172653
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.63878231
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63618607
98TGF-beta signaling pathway_Homo sapiens_hsa043500.63391595
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62131862
100Malaria_Homo sapiens_hsa051440.61370245
101Hepatitis B_Homo sapiens_hsa051610.60913629
102Alcoholism_Homo sapiens_hsa050340.59662944
103ECM-receptor interaction_Homo sapiens_hsa045120.58475665
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.56971121
105Adherens junction_Homo sapiens_hsa045200.56903754
106Staphylococcus aureus infection_Homo sapiens_hsa051500.54803970
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.54569675
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.54258807
109Fatty acid biosynthesis_Homo sapiens_hsa000610.52597528
110T cell receptor signaling pathway_Homo sapiens_hsa046600.51289484
111HIF-1 signaling pathway_Homo sapiens_hsa040660.50672197
112Amoebiasis_Homo sapiens_hsa051460.50591353
113MAPK signaling pathway_Homo sapiens_hsa040100.49493537
114AMPK signaling pathway_Homo sapiens_hsa041520.49088253
115Tight junction_Homo sapiens_hsa045300.46652550
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46617594
117Focal adhesion_Homo sapiens_hsa045100.43207962
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.41197834
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39454013
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.39068080
121Measles_Homo sapiens_hsa051620.38795940
122Pentose phosphate pathway_Homo sapiens_hsa000300.38631058
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38000351
124Acute myeloid leukemia_Homo sapiens_hsa052210.37797388
125mTOR signaling pathway_Homo sapiens_hsa041500.37779998
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36720211
127Prostate cancer_Homo sapiens_hsa052150.35256741
128Hematopoietic cell lineage_Homo sapiens_hsa046400.34626176
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33945053
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.33845616
131Toxoplasmosis_Homo sapiens_hsa051450.32498715
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30588975
133Endometrial cancer_Homo sapiens_hsa052130.30437756
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29664939
135Melanogenesis_Homo sapiens_hsa049160.28525564
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28332951
137Renal cell carcinoma_Homo sapiens_hsa052110.27826496
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27008923
139Melanoma_Homo sapiens_hsa052180.26101948
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25918948
141Protein export_Homo sapiens_hsa030600.25084838
142Pancreatic cancer_Homo sapiens_hsa052120.24405504
143Endocytosis_Homo sapiens_hsa041440.24084986
144Salmonella infection_Homo sapiens_hsa051320.23405236
145Biosynthesis of amino acids_Homo sapiens_hsa012300.23051702
146Non-small cell lung cancer_Homo sapiens_hsa052230.22931072
147Axon guidance_Homo sapiens_hsa043600.21921828

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