SLC7A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)5.69818792
2regulation of posttranscriptional gene silencing (GO:0060147)5.62485586
3regulation of gene silencing by miRNA (GO:0060964)5.62485586
4regulation of gene silencing by RNA (GO:0060966)5.62485586
5neutrophil activation involved in immune response (GO:0002283)5.17686363
6positive regulation by symbiont of host defense response (GO:0052509)4.93749122
7modulation by symbiont of host defense response (GO:0052031)4.93749122
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.93749122
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.93749122
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.93749122
11modulation by symbiont of host immune response (GO:0052553)4.93749122
12positive regulation of gamma-delta T cell activation (GO:0046645)4.75621702
13response to peptidoglycan (GO:0032494)4.75201837
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.68454844
15negative regulation of cell killing (GO:0031342)4.68454844
16negative regulation of interleukin-12 production (GO:0032695)4.64696533
17macrophage activation involved in immune response (GO:0002281)4.62126725
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58985087
19urate metabolic process (GO:0046415)4.35360112
20detection of other organism (GO:0098543)4.30876371
21immunoglobulin mediated immune response (GO:0016064)4.28275310
22detection of bacterium (GO:0016045)4.06012236
23antigen processing and presentation of endogenous antigen (GO:0019883)4.04281661
24modified amino acid transport (GO:0072337)4.01131768
25drug transport (GO:0015893)4.00837962
26folic acid-containing compound biosynthetic process (GO:0009396)3.99272992
27folic acid metabolic process (GO:0046655)3.97002672
28L-alpha-amino acid transmembrane transport (GO:1902475)3.90507358
29intestinal absorption (GO:0050892)3.89064254
30positive regulation of SMAD protein import into nucleus (GO:0060391)3.87921713
31drug transmembrane transport (GO:0006855)3.86506035
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.84919504
33cellular extravasation (GO:0045123)3.81309919
34nucleobase biosynthetic process (GO:0046112)3.78788064
35lysine metabolic process (GO:0006553)3.78302603
36lysine catabolic process (GO:0006554)3.78302603
37peptide catabolic process (GO:0043171)3.77757406
38detection of external biotic stimulus (GO:0098581)3.67104607
39detection of molecule of bacterial origin (GO:0032490)3.65124553
40regulation of interferon-beta biosynthetic process (GO:0045357)3.63416180
41purine nucleobase biosynthetic process (GO:0009113)3.61998658
42neutrophil activation (GO:0042119)3.59653033
43granulocyte activation (GO:0036230)3.57136099
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56873479
45positive regulation of mast cell activation (GO:0033005)3.56824760
46histone arginine methylation (GO:0034969)3.56055256
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.53966400
48regulation of mast cell degranulation (GO:0043304)3.51791861
49renal absorption (GO:0070293)3.51615403
50phosphate ion transport (GO:0006817)3.46575560
51respiratory burst (GO:0045730)3.45677091
52regulation of SMAD protein import into nucleus (GO:0060390)3.45407289
53regulation of gamma-delta T cell activation (GO:0046643)3.45276237
54angiotensin maturation (GO:0002003)3.43582524
55myeloid cell activation involved in immune response (GO:0002275)3.41844724
56phospholipid efflux (GO:0033700)3.41587262
57anterior/posterior axis specification, embryo (GO:0008595)3.40624884
58macrophage activation (GO:0042116)3.40340856
59DNA unwinding involved in DNA replication (GO:0006268)3.38719428
60microglial cell activation (GO:0001774)3.35187097
61regulation of B cell receptor signaling pathway (GO:0050855)3.33711951
62detection of biotic stimulus (GO:0009595)3.32318613
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.30700379
64lipopolysaccharide-mediated signaling pathway (GO:0031663)3.30515858
65regulation of myeloid leukocyte mediated immunity (GO:0002886)3.30300796
66formation of translation preinitiation complex (GO:0001731)3.27449974
67interferon-gamma-mediated signaling pathway (GO:0060333)3.26452131
68regulation of cytokine secretion involved in immune response (GO:0002739)3.25991209
69regulation of mast cell activation involved in immune response (GO:0033006)3.24137099
70ribosome assembly (GO:0042255)3.23203563
71positive regulation of mast cell degranulation (GO:0043306)3.22377930
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.22377930
73regulation of leukocyte degranulation (GO:0043300)3.20378045
74glycosphingolipid catabolic process (GO:0046479)3.19910128
75IMP biosynthetic process (GO:0006188)3.19235675
76maturation of SSU-rRNA (GO:0030490)3.19212891
77regulation of mast cell activation (GO:0033003)3.18920644
78drug catabolic process (GO:0042737)3.17934856
79B cell mediated immunity (GO:0019724)3.17693844
80positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.16958092
81positive regulation of antigen processing and presentation (GO:0002579)3.16927419
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.16733993
83response to host immune response (GO:0052572)3.16733993
84phosphate ion transmembrane transport (GO:0035435)3.16061695
85regulation of antigen processing and presentation (GO:0002577)3.15505743
86negative regulation of cytokine production involved in immune response (GO:0002719)3.12691477
87negative regulation of gene silencing (GO:0060969)3.10021632
88oligosaccharide catabolic process (GO:0009313)3.07639216
89production of molecular mediator involved in inflammatory response (GO:0002532)3.07045820
90regulation of T cell tolerance induction (GO:0002664)3.04182894
91DNA strand elongation involved in DNA replication (GO:0006271)3.03505070
92nuclear pore organization (GO:0006999)3.02280814
93positive regulation of cellular amide metabolic process (GO:0034250)3.01798060
94DNA replication initiation (GO:0006270)3.00423637
95T-helper 1 type immune response (GO:0042088)2.98860573
96trophectodermal cell differentiation (GO:0001829)2.98791516
97nodal signaling pathway (GO:0038092)2.98762036
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98247348
99vitamin D metabolic process (GO:0042359)2.97589731
100positive regulation of leukocyte degranulation (GO:0043302)2.96285693
101negative regulation of interleukin-1 beta production (GO:0032691)2.94305395
102glycolipid catabolic process (GO:0019377)2.92901703
103protein complex localization (GO:0031503)2.92828167
104defense response to protozoan (GO:0042832)2.91493076
105regulation of tolerance induction (GO:0002643)2.91353647
106embryonic process involved in female pregnancy (GO:0060136)2.89271941
107pteridine-containing compound biosynthetic process (GO:0042559)2.88339089
108proline metabolic process (GO:0006560)2.87890422
109plasma lipoprotein particle assembly (GO:0034377)2.87640138
110cellular response to type I interferon (GO:0071357)2.87515475
111type I interferon signaling pathway (GO:0060337)2.87515475
112leukocyte aggregation (GO:0070486)2.87093532
113positive regulation of type 2 immune response (GO:0002830)2.86989791
114regulation of gene silencing (GO:0060968)2.86423026
115intestinal cholesterol absorption (GO:0030299)2.84666187
116response to type I interferon (GO:0034340)2.83875765
117response to host defenses (GO:0052200)2.83774684
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83774684
119response to host (GO:0075136)2.83774684
120ribosomal large subunit biogenesis (GO:0042273)2.83739551
121DNA strand elongation (GO:0022616)2.83371581
122organic cation transport (GO:0015695)2.81474278
123mitotic nuclear envelope disassembly (GO:0007077)2.81391195
124NIK/NF-kappaB signaling (GO:0038061)2.81376666
125DNA replication-dependent nucleosome organization (GO:0034723)2.80420913
126DNA replication-dependent nucleosome assembly (GO:0006335)2.80420913
127paraxial mesoderm development (GO:0048339)2.80327752
128positive regulation of toll-like receptor signaling pathway (GO:0034123)2.79142664
129negative regulation of interleukin-1 production (GO:0032692)2.79044607
130negative regulation of lymphocyte mediated immunity (GO:0002707)2.78979404
131homocysteine metabolic process (GO:0050667)2.77952543
132mitotic metaphase plate congression (GO:0007080)2.77804047
133folic acid-containing compound metabolic process (GO:0006760)2.77522243
134regulation of T-helper 2 cell differentiation (GO:0045628)2.77254087
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76355369
136cellular response to thyroid hormone stimulus (GO:0097067)2.76259872
137regulation of interleukin-8 biosynthetic process (GO:0045414)2.75922097
138response to muramyl dipeptide (GO:0032495)2.75725738
139heterochromatin organization (GO:0070828)2.75428823
140regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75030819
141response to hepatocyte growth factor (GO:0035728)2.74983967
142cellular response to hepatocyte growth factor stimulus (GO:0035729)2.74983967
143response to protozoan (GO:0001562)2.73817960
144amino sugar catabolic process (GO:0046348)2.73175966
145germinal center formation (GO:0002467)2.73160116
146serine family amino acid biosynthetic process (GO:0009070)2.71432514
147IMP metabolic process (GO:0046040)2.71083043
148positive regulation of monocyte chemotaxis (GO:0090026)2.70815269
149myeloid leukocyte activation (GO:0002274)2.69123743
150negative regulation of T cell mediated immunity (GO:0002710)2.68985879
151regulation of regulated secretory pathway (GO:1903305)2.68750189
152regulation of cholesterol esterification (GO:0010872)2.68259054
153interferon-gamma secretion (GO:0072643)2.67664197
154folic acid transport (GO:0015884)2.66851452
155tetrahydrofolate metabolic process (GO:0046653)2.66508102
156protein-lipid complex assembly (GO:0065005)2.64750058
157regulation of protein heterodimerization activity (GO:0043497)2.64580234
158antigen processing and presentation via MHC class Ib (GO:0002475)2.64350440
159viral transcription (GO:0019083)2.63499191
160glycoside metabolic process (GO:0016137)2.63360337
161neutrophil mediated immunity (GO:0002446)2.62785578
162vitamin transport (GO:0051180)2.62405561
163nuclear pore complex assembly (GO:0051292)2.62169754
164regulation of mononuclear cell migration (GO:0071675)2.62151467
165nuclear envelope disassembly (GO:0051081)2.59459689
166membrane disassembly (GO:0030397)2.59459689
167adhesion of symbiont to host cell (GO:0044650)2.59297334
168virion attachment to host cell (GO:0019062)2.59297334
169regulation of translational fidelity (GO:0006450)2.59079215
170serine family amino acid metabolic process (GO:0009069)2.58749704
171regulation of hippo signaling (GO:0035330)2.58313575
172translational termination (GO:0006415)2.58275068
173intestinal epithelial cell development (GO:0060576)2.57896509
174regulation of histone H3-K9 methylation (GO:0051570)2.56589927
175toxin transport (GO:1901998)2.56390900
176basic amino acid transport (GO:0015802)2.55929039
177regulation of helicase activity (GO:0051095)2.54073183
178sulfur compound transport (GO:0072348)2.52606663
179determination of adult lifespan (GO:0008340)2.52321302
180cysteine metabolic process (GO:0006534)2.50651564
181telomere maintenance via semi-conservative replication (GO:0032201)2.47459317
182translational elongation (GO:0006414)2.47439176
183pre-miRNA processing (GO:0031054)2.47319566
184negative regulation of androgen receptor signaling pathway (GO:0060766)2.46883312
185excretion (GO:0007588)2.44888288
186nucleoside salvage (GO:0043174)2.44711710
187purine nucleotide salvage (GO:0032261)2.42469023
188exogenous drug catabolic process (GO:0042738)2.41956434
189pteridine-containing compound metabolic process (GO:0042558)2.41907821
190glycine metabolic process (GO:0006544)2.37921641
191ribosome biogenesis (GO:0042254)2.37345388
192cytidine deamination (GO:0009972)2.36876923
193cytidine metabolic process (GO:0046087)2.36876923
194cytidine catabolic process (GO:0006216)2.36876923
195translational initiation (GO:0006413)2.36172045
196metaphase plate congression (GO:0051310)2.35797717
197regulation of translational termination (GO:0006449)2.35526134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48323815
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.87300108
3IRF8_27001747_Chip-Seq_BMDM_Mouse3.67540112
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.46096675
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.30109340
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22171295
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17465382
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.10837861
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96102399
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93438207
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92033910
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.72083044
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.72083044
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.72083044
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.66699377
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63479803
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63381688
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61822691
19* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46354131
20* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.43805890
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.41452202
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38044547
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.37520892
24VDR_24763502_ChIP-Seq_THP-1_Human2.36068115
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35386466
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.34338737
27* SPI1_23547873_ChIP-Seq_NB4_Human2.29607219
28* SPI1_23127762_ChIP-Seq_K562_Human2.28849006
29STAT3_1855785_ChIP-Seq_MESCs_Mouse2.26796456
30* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.21728556
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.20173684
32VDR_24787735_ChIP-Seq_THP-1_Human2.19987876
33* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15361045
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10567543
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08866611
36MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04289861
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03999730
38RUNX_20019798_ChIP-Seq_JUKART_Human2.03986078
39AR_21909140_ChIP-Seq_LNCAP_Human2.02262022
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93893674
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92570473
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90492412
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89701955
44* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.89254469
45* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88131740
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87916287
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.87743871
48GATA1_22025678_ChIP-Seq_K562_Human1.82141371
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.81530971
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.77831728
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74944808
52SCL_19346495_ChIP-Seq_HPC-7_Human1.73773511
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73643979
54XRN2_22483619_ChIP-Seq_HELA_Human1.67307989
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64733560
56MYB_26560356_Chip-Seq_TH2_Human1.64638802
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63406097
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60339118
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60263645
60* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.58664932
61MAF_26560356_Chip-Seq_TH1_Human1.58175196
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57899611
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57436216
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55855059
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55254472
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52277686
67* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.51433393
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51167137
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51093292
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49136476
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.49073085
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48571240
73* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47925219
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45910532
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.45488023
76* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44397870
77* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.44198463
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44144599
79MYC_22102868_ChIP-Seq_BL_Human1.43500992
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42269995
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37785426
82* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.37684894
83UTX_26944678_Chip-Seq_JUKART_Human1.37209340
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34989265
85* GATA1_19941827_ChIP-Seq_MEL_Mouse1.34481062
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34419324
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.33269469
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32758777
89MYB_26560356_Chip-Seq_TH1_Human1.32745317
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32131530
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31305214
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31215953
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30490945
94* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30268134
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.29041807
96GATA3_27048872_Chip-Seq_THYMUS_Human1.28868876
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28691867
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27074187
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26631366
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26459548
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.26411122
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25227013
103PU_27001747_Chip-Seq_BMDM_Mouse1.24694936
104LXR_22292898_ChIP-Seq_THP-1_Human1.21641262
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20783639
106* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19518872
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18923372
108TCF7_22412390_ChIP-Seq_EML_Mouse1.18738880
109GATA1_19941826_ChIP-Seq_K562_Human1.18493387
110SMAD_19615063_ChIP-ChIP_OVARY_Human1.18407826
111* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.18219476
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18000118
113* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17592978
114* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17269347
115GATA3_26560356_Chip-Seq_TH2_Human1.16460642
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16180443
117YY1_21170310_ChIP-Seq_MESCs_Mouse1.16099653
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15946232
119GATA2_21666600_ChIP-Seq_HMVEC_Human1.15460444
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14864760
121TFEB_21752829_ChIP-Seq_HELA_Human1.14660069
122LXR_22158963_ChIP-Seq_LIVER_Mouse1.14615385
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14096286
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14047363
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13833950
126TTF2_22483619_ChIP-Seq_HELA_Human1.11502267
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10622812
128* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09251227
129E2F1_21310950_ChIP-Seq_MCF-7_Human1.09147216
130GABP_17652178_ChIP-ChIP_JURKAT_Human1.08514895
131HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08405618
132* GATA6_25053715_ChIP-Seq_YYC3_Human1.08212418
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08194541
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08172504
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08150414
136BCOR_27268052_Chip-Seq_Bcells_Human1.08000777
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07995508
138* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07568919
139PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07531928
140GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07531492
141ATF3_27146783_Chip-Seq_COLON_Human1.06449266
142BCL6_27268052_Chip-Seq_Bcells_Human1.05781203
143* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05735771
144MAF_26560356_Chip-Seq_TH2_Human1.05514433
145TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05335400
146VDR_23849224_ChIP-Seq_CD4+_Human1.04701951
147VDR_21846776_ChIP-Seq_THP-1_Human1.04615916
148DCP1A_22483619_ChIP-Seq_HELA_Human1.04494670
149EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04412222
150ESR1_21235772_ChIP-Seq_MCF-7_Human1.04382425
151KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02189000
152ELK3_25401928_ChIP-Seq_HUVEC_Human1.00594177
153CDX2_20551321_ChIP-Seq_CACO-2_Human1.00497314
154GABP_19822575_ChIP-Seq_HepG2_Human0.98346203
155GATA2_19941826_ChIP-Seq_K562_Human0.97835932
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97239859
157ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96849318
158VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96735775
159KDM2B_26808549_Chip-Seq_DND41_Human0.96565443
160GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96361617
161RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95018699
162POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94693771
163PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93821315
164ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93609521
165IRF8_22096565_ChIP-ChIP_GC-B_Human0.93371944
166KAP1_27257070_Chip-Seq_ESCs_Mouse0.93041159
167ZNF263_19887448_ChIP-Seq_K562_Human0.92907754
168ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92731936
169* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92258034
170GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92110162
171FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91703362
172SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91527371
173* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91477218
174* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91191268
175CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90294891
176* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89561579
177TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89220881
178CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88295376
179FOXP3_21729870_ChIP-Seq_TREG_Human0.87541521
180MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.87433093
181KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87340585
182STAT1_20625510_ChIP-Seq_HELA_Human0.86329540
183KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79552772
184CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79044337
185KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78169094
186SMRT_27268052_Chip-Seq_Bcells_Human0.73678356
187BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72727825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.26808113
2MP0003724_increased_susceptibility_to3.87002327
3MP0003303_peritoneal_inflammation3.78486074
4MP0003693_abnormal_embryo_hatching3.31134690
5MP0010352_gastrointestinal_tract_polyps2.92864112
6MP0009785_altered_susceptibility_to2.92665110
7MP0002419_abnormal_innate_immunity2.90686933
8MP0003806_abnormal_nucleotide_metabolis2.86471178
9MP0002148_abnormal_hypersensitivity_rea2.77588930
10MP0005671_abnormal_response_to2.71606315
11MP0004019_abnormal_vitamin_homeostasis2.67517045
12MP0001790_abnormal_immune_system2.64118549
13MP0005387_immune_system_phenotype2.64118549
14MP0004957_abnormal_blastocyst_morpholog2.63876249
15MP0005025_abnormal_response_to2.60439589
16MP0005000_abnormal_immune_tolerance2.53984997
17MP0001800_abnormal_humoral_immune2.37540193
18MP0000685_abnormal_immune_system2.36556821
19MP0002452_abnormal_antigen_presenting2.28180740
20MP0009840_abnormal_foam_cell2.26770993
21MP0002723_abnormal_immune_serum2.23023221
22MP0010234_abnormal_vibrissa_follicle2.16812841
23MP0004133_heterotaxia2.15357903
24* MP0005332_abnormal_amino_acid2.13447680
25MP0004264_abnormal_extraembryonic_tissu2.11576014
26MP0003878_abnormal_ear_physiology2.07098716
27MP0005377_hearing/vestibular/ear_phenot2.07098716
28* MP0009643_abnormal_urine_homeostasis2.04429894
29MP0002420_abnormal_adaptive_immunity2.01311331
30MP0001819_abnormal_immune_cell2.00883097
31MP0001533_abnormal_skeleton_physiology2.00306440
32MP0004043_abnormal_pH_regulation1.99948602
33MP0000604_amyloidosis1.96766765
34MP0005464_abnormal_platelet_physiology1.93913317
35MP0003111_abnormal_nucleus_morphology1.91798648
36MP0003191_abnormal_cellular_cholesterol1.89437087
37MP0003077_abnormal_cell_cycle1.87381033
38MP0002136_abnormal_kidney_physiology1.83261383
39MP0005058_abnormal_lysosome_morphology1.80574558
40MP0009764_decreased_sensitivity_to1.79378611
41MP0001666_abnormal_nutrient_absorption1.77976879
42MP0001730_embryonic_growth_arrest1.73881438
43MP0002138_abnormal_hepatobiliary_system1.71801296
44MP0005451_abnormal_body_composition1.65406043
45MP0002254_reproductive_system_inflammat1.64319599
46MP0010094_abnormal_chromosome_stability1.63611376
47MP0010307_abnormal_tumor_latency1.61443471
48MP0003075_altered_response_to1.58795005
49MP0008260_abnormal_autophagy1.58418464
50MP0002405_respiratory_system_inflammati1.56873310
51MP0000490_abnormal_crypts_of1.54992151
52MP0008058_abnormal_DNA_repair1.53808259
53MP0004947_skin_inflammation1.52974591
54MP0002139_abnormal_hepatobiliary_system1.52691534
55MP0000343_altered_response_to1.52514240
56MP0008004_abnormal_stomach_pH1.52024527
57MP0002998_abnormal_bone_remodeling1.51507400
58MP0003186_abnormal_redox_activity1.49373776
59MP0005085_abnormal_gallbladder_physiolo1.48747471
60MP0005365_abnormal_bile_salt1.48126614
61MP0001756_abnormal_urination1.47206247
62MP0000716_abnormal_immune_system1.43043374
63MP0003828_pulmonary_edema1.42643517
64MP0005310_abnormal_salivary_gland1.41388587
65MP0005166_decreased_susceptibility_to1.39894503
66MP0003566_abnormal_cell_adhesion1.39085592
67MP0003690_abnormal_glial_cell1.37995878
68MP0003252_abnormal_bile_duct1.37932220
69MP0008932_abnormal_embryonic_tissue1.35165362
70MP0003705_abnormal_hypodermis_morpholog1.33934814
71MP0003436_decreased_susceptibility_to1.32434307
72MP0004510_myositis1.31736645
73MP0001849_ear_inflammation1.31057611
74MP0000350_abnormal_cell_proliferation1.28493768
75MP0008007_abnormal_cellular_replicative1.28266572
76MP0003941_abnormal_skin_development1.23548731
77MP0002653_abnormal_ependyma_morphology1.21854700
78MP0002398_abnormal_bone_marrow1.17576258
79MP0002396_abnormal_hematopoietic_system1.17400802
80MP0003718_maternal_effect1.16531365
81MP0004883_abnormal_blood_vessel1.14125535
82MP0000465_gastrointestinal_hemorrhage1.14075700
83MP0002086_abnormal_extraembryonic_tissu1.11620001
84* MP0001697_abnormal_embryo_size1.11534639
85MP0005023_abnormal_wound_healing1.10428149
86MP0000858_altered_metastatic_potential1.10283928
87* MP0001672_abnormal_embryogenesis/_devel1.08915071
88* MP0005380_embryogenesis_phenotype1.08915071
89MP0002429_abnormal_blood_cell1.08102520
90MP0003300_gastrointestinal_ulcer1.07515487
91MP0003866_abnormal_defecation1.07228809
92MP0002796_impaired_skin_barrier1.07131983
93MP0008057_abnormal_DNA_replication1.06963367
94MP0005636_abnormal_mineral_homeostasis1.06586536
95MP0000477_abnormal_intestine_morphology1.06341517
96MP0005501_abnormal_skin_physiology1.03047928
97MP0005164_abnormal_response_to1.02709424
98MP0003329_amyloid_beta_deposits1.01756495
99MP0002277_abnormal_respiratory_mucosa0.99883258
100MP0009333_abnormal_splenocyte_physiolog0.99401413
101MP0003283_abnormal_digestive_organ0.99116506
102* MP0003984_embryonic_growth_retardation0.98695749
103MP0001765_abnormal_ion_homeostasis0.98558441
104MP0001835_abnormal_antigen_presentation0.98454197
105* MP0002088_abnormal_embryonic_growth/wei0.98091000
106* MP0002722_abnormal_immune_system0.97035280
107MP0002085_abnormal_embryonic_tissue0.96507017
108MP0002084_abnormal_developmental_patter0.96462080
109MP0010155_abnormal_intestine_physiology0.95109957
110MP0004858_abnormal_nervous_system0.94929002
111MP0010030_abnormal_orbit_morphology0.94440690
112MP0005076_abnormal_cell_differentiation0.93681303
113MP0002080_prenatal_lethality0.93621563
114MP0000538_abnormal_urinary_bladder0.93361145
115MP0003183_abnormal_peptide_metabolism0.93049388
116MP0006082_CNS_inflammation0.92138255
117MP0003172_abnormal_lysosome_physiology0.91655450
118MP0003763_abnormal_thymus_physiology0.91413953
119MP0000313_abnormal_cell_death0.91152386
120MP0002132_abnormal_respiratory_system0.91133061
121MP0005319_abnormal_enzyme/_coenzyme0.90075551
122MP0002135_abnormal_kidney_morphology0.89301967
123MP0003890_abnormal_embryonic-extraembry0.88963727
124MP0009278_abnormal_bone_marrow0.87857030
125MP0001293_anophthalmia0.87804671
126MP0008875_abnormal_xenobiotic_pharmacok0.85571850
127MP0009763_increased_sensitivity_to0.83893312
128MP0010329_abnormal_lipoprotein_level0.83815086
129MP0001986_abnormal_taste_sensitivity0.83145557
130MP0001764_abnormal_homeostasis0.82977463
131MP0001915_intracranial_hemorrhage0.82303981
132MP0001873_stomach_inflammation0.81216006
133MP0005167_abnormal_blood-brain_barrier0.80790388
134MP0006054_spinal_hemorrhage0.80653806
135MP0003119_abnormal_digestive_system0.80402031
136MP0000598_abnormal_liver_morphology0.80247308
137MP0000249_abnormal_blood_vessel0.79085781
138MP0000537_abnormal_urethra_morphology0.78617943
139MP0000920_abnormal_myelination0.77065089
140MP0001845_abnormal_inflammatory_respons0.76945147
141MP0001851_eye_inflammation0.76734197
142MP0003315_abnormal_perineum_morphology0.76486833
143MP0001663_abnormal_digestive_system0.76140623
144* MP0000689_abnormal_spleen_morphology0.75756337
145MP0002019_abnormal_tumor_incidence0.75590700
146MP0005266_abnormal_metabolism0.75522422
147MP0003638_abnormal_response/metabolism_0.75480314
148MP0008469_abnormal_protein_level0.75458088
149MP0001545_abnormal_hematopoietic_system0.75411399
150MP0005397_hematopoietic_system_phenotyp0.75411399
151MP0003195_calcinosis0.75200976
152MP0005390_skeleton_phenotype0.72762261
153MP0003448_altered_tumor_morphology0.69562256
154MP0001853_heart_inflammation0.69481003
155MP0003795_abnormal_bone_structure0.68995055
156MP0000609_abnormal_liver_physiology0.68808084
157MP0003879_abnormal_hair_cell0.66476607
158MP0003656_abnormal_erythrocyte_physiolo0.64846043
159MP0009765_abnormal_xenobiotic_induced0.64685411
160MP0003453_abnormal_keratinocyte_physiol0.64097116
161MP0005584_abnormal_enzyme/coenzyme_acti0.61070768
162MP0002118_abnormal_lipid_homeostasis0.60850681
163MP0008874_decreased_physiological_sensi0.58715325

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.07192527
2* Abnormality of macrophages (HP:0004311)5.78141420
3Recurrent bacterial skin infections (HP:0005406)5.55478661
4Recurrent abscess formation (HP:0002722)5.46391259
5Abnormality of glycolipid metabolism (HP:0010969)5.33482032
6Abnormality of liposaccharide metabolism (HP:0010968)5.33482032
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.33482032
8Abnormality of glutamine family amino acid metabolism (HP:0010902)5.01510213
9Recurrent gram-negative bacterial infections (HP:0005420)4.73211577
10Myositis (HP:0100614)4.44526369
11Orchitis (HP:0100796)4.41429675
12Stomatitis (HP:0010280)4.17121873
13Retrobulbar optic neuritis (HP:0100654)4.11883975
14Optic neuritis (HP:0100653)4.11883975
15Hyperglycinuria (HP:0003108)4.11621116
16Increased cerebral lipofuscin (HP:0011813)4.01279176
17Hydroxyprolinuria (HP:0003080)3.92794393
18Abnormality of proline metabolism (HP:0010907)3.92794393
19Hyperactive renin-angiotensin system (HP:0000841)3.91503765
20Amyloidosis (HP:0011034)3.87113089
21Mediastinal lymphadenopathy (HP:0100721)3.81361320
22Hypomagnesemia (HP:0002917)3.73259868
23Gout (HP:0001997)3.67373890
24Abnormal urine output (HP:0012590)3.58446402
25Increased circulating renin level (HP:0000848)3.57721623
26Abnormality of magnesium homeostasis (HP:0004921)3.56672659
27Abnormality of chloride homeostasis (HP:0011422)3.55869309
28Proximal tubulopathy (HP:0000114)3.55201692
29Polyuria (HP:0000103)3.54360060
30Loss of speech (HP:0002371)3.53969268
31Abnormality of renal excretion (HP:0011036)3.52017146
32Recurrent skin infections (HP:0001581)3.50799214
33Elevated erythrocyte sedimentation rate (HP:0003565)3.47479362
34Metabolic alkalosis (HP:0200114)3.40533010
35Reticulocytopenia (HP:0001896)3.38909680
36Recurrent fungal infections (HP:0002841)3.36775986
37Hypokalemic alkalosis (HP:0001949)3.33875021
38Obstructive lung disease (HP:0006536)3.25213087
39Chronic obstructive pulmonary disease (HP:0006510)3.25213087
40Increased neuronal autofluorescent lipopigment (HP:0002074)3.20749362
41Metaphyseal cupping (HP:0003021)3.16271446
42Gingivitis (HP:0000230)3.15230456
43Carpal bone hypoplasia (HP:0001498)3.14574151
44Renal salt wasting (HP:0000127)3.09923968
45Vacuolated lymphocytes (HP:0001922)3.07193164
46Systemic lupus erythematosus (HP:0002725)3.05326195
47Disinhibition (HP:0000734)3.03969449
48Autoimmune thrombocytopenia (HP:0001973)3.01712665
49Vasculitis (HP:0002633)2.99416377
50Gingival bleeding (HP:0000225)2.98436362
51Meningitis (HP:0001287)2.96727011
52Abnormality of purine metabolism (HP:0004352)2.96043283
53Gastrointestinal infarctions (HP:0005244)2.91485297
54Abnormality of glycine metabolism (HP:0010895)2.89628616
55Abnormality of serine family amino acid metabolism (HP:0010894)2.89628616
56Chronic mucocutaneous candidiasis (HP:0002728)2.86702707
57Recurrent cutaneous fungal infections (HP:0011370)2.86702707
58Increased purine levels (HP:0004368)2.86320672
59Hyperuricemia (HP:0002149)2.86320672
60Spontaneous hematomas (HP:0007420)2.84953876
61Petechiae (HP:0000967)2.83027928
62Urticaria (HP:0001025)2.82422821
63Pulmonary infiltrates (HP:0002113)2.82036512
64Agnosia (HP:0010524)2.80775067
65Abnormality of polysaccharide metabolism (HP:0011012)2.79010123
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.79010123
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.79010123
68Encephalitis (HP:0002383)2.78232540
69Keratoconjunctivitis sicca (HP:0001097)2.77625030
70Hemoptysis (HP:0002105)2.77155533
71Mutism (HP:0002300)2.67221033
72Hypercalciuria (HP:0002150)2.61473719
73Keratoconjunctivitis (HP:0001096)2.58840707
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.53302852
75Generalized aminoaciduria (HP:0002909)2.53051689
76Abnormality of urine glucose concentration (HP:0011016)2.52612050
77Glycosuria (HP:0003076)2.52612050
78* Malnutrition (HP:0004395)2.50417227
79Alkalosis (HP:0001948)2.48158770
80Megaloblastic anemia (HP:0001889)2.47864439
81Purpura (HP:0000979)2.47463322
82Abnormal drinking behavior (HP:0030082)2.45991107
83Polydipsia (HP:0001959)2.45991107
84* Abnormality of nucleobase metabolism (HP:0010932)2.45415395
85Abnormality of sulfur amino acid metabolism (HP:0004339)2.42713857
86Episodic fever (HP:0001954)2.41848847
87Tetany (HP:0001281)2.41190763
88Pustule (HP:0200039)2.38883455
89Recurrent viral infections (HP:0004429)2.38725607
90Hematochezia (HP:0002573)2.37711398
91Macrocytic anemia (HP:0001972)2.35807899
92Polyneuropathy (HP:0001271)2.34212875
93Dehydration (HP:0001944)2.33309142
94Abnormal trabecular bone morphology (HP:0100671)2.32720640
95Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32563864
96Epistaxis (HP:0000421)2.32287369
97T lymphocytopenia (HP:0005403)2.31677932
98Rough bone trabeculation (HP:0100670)2.31401939
99Leukocytosis (HP:0001974)2.30819537
100Abnormality of T cell number (HP:0011839)2.25380575
101Mesangial abnormality (HP:0001966)2.24710663
102Cellulitis (HP:0100658)2.24071179
103Nephrolithiasis (HP:0000787)2.23501935
104Chest pain (HP:0100749)2.23343353
105Myocardial infarction (HP:0001658)2.23072140
106Osteomyelitis (HP:0002754)2.21397893
107Delayed epiphyseal ossification (HP:0002663)2.20930187
108Multiple enchondromatosis (HP:0005701)2.19931197
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18192926
110Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.18167882
111Joint swelling (HP:0001386)2.18034105
112Rhabdomyosarcoma (HP:0002859)2.17392320
113Premature loss of primary teeth (HP:0006323)2.17356089
114Increased IgM level (HP:0003496)2.16832209
115Spastic diplegia (HP:0001264)2.16341438
116Increased IgE level (HP:0003212)2.16186291
117Ileus (HP:0002595)2.15996476
118Anorexia (HP:0002039)2.15335033
119Inflammation of the large intestine (HP:0002037)2.14610023
120Glomerulonephritis (HP:0000099)2.10971751
121Hyperphosphaturia (HP:0003109)2.10661158
122Arterial thrombosis (HP:0004420)2.10635349
123Widely patent fontanelles and sutures (HP:0004492)2.10527655
124Prolonged bleeding time (HP:0003010)2.09968605
125Chronic diarrhea (HP:0002028)2.09338432
126Aplasia/hypoplasia of the humerus (HP:0006507)2.07858198
127Ependymoma (HP:0002888)2.07262927
128Abnormality of renin-angiotensin system (HP:0000847)2.06123645
129High anterior hairline (HP:0009890)2.05961598
130Abdominal situs inversus (HP:0003363)2.04643926
131Abnormality of abdominal situs (HP:0011620)2.04643926
132Pulmonary embolism (HP:0002204)2.04545103
133Progressive neurologic deterioration (HP:0002344)2.04534078
134Breast hypoplasia (HP:0003187)2.02889960
135Colon cancer (HP:0003003)2.02485283
136Hepatosplenomegaly (HP:0001433)2.02424383
137Abnormal urine phosphate concentration (HP:0012599)2.02327098
138Trismus (HP:0000211)2.00959244
139Gastrointestinal inflammation (HP:0004386)1.99985287
140Hyponatremia (HP:0002902)1.99414556
141Colitis (HP:0002583)1.99194537
142Recurrent pneumonia (HP:0006532)1.98361688
143Renal tubular acidosis (HP:0001947)1.97516294
144IgM deficiency (HP:0002850)1.97024531
145Retinal atrophy (HP:0001105)1.96404115
146Degeneration of anterior horn cells (HP:0002398)1.95983282
147Abnormality of the anterior horn cell (HP:0006802)1.95983282
148Gangrene (HP:0100758)1.95163049
149Hyperaldosteronism (HP:0000859)1.94680914
150Short humerus (HP:0005792)1.94644576
151Flat acetabular roof (HP:0003180)1.91908781
152Neurofibrillary tangles (HP:0002185)1.91888032
153Restrictive lung disease (HP:0002091)1.91848293
154Abnormality of the pleura (HP:0002103)1.91636640
155Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91350491
156* Increased serum ferritin (HP:0003281)1.91079224
157Gastrointestinal stroma tumor (HP:0100723)1.90267901
158Complement deficiency (HP:0004431)1.88342822
159Neuronal loss in central nervous system (HP:0002529)1.87554088
160Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.87371311
161Urethral obstruction (HP:0000796)1.87309374
162Metaphyseal irregularity (HP:0003025)1.86955847
163Increased CSF protein (HP:0002922)1.86542484
164Axonal loss (HP:0003447)1.86045640
165Birth length less than 3rd percentile (HP:0003561)1.85801645
166Confusion (HP:0001289)1.83749549
167Vertigo (HP:0002321)1.83412305
168Tubular atrophy (HP:0000092)1.83084776
169Dysostosis multiplex (HP:0000943)1.83016167
170Oral leukoplakia (HP:0002745)1.82387973
171Abnormality of reticulocytes (HP:0004312)1.80326778
172Abnormality of T cells (HP:0002843)1.80221735
173Hypergammaglobulinemia (HP:0010702)1.79480545
174Hypophosphatemia (HP:0002148)1.78448280
175Spinal muscular atrophy (HP:0007269)1.77603745
176Rectal fistula (HP:0100590)1.77435138
177Rectovaginal fistula (HP:0000143)1.77435138
178Vaginal fistula (HP:0004320)1.76993025
179Urinary glycosaminoglycan excretion (HP:0003541)1.76886685
180Mucopolysacchariduria (HP:0008155)1.76886685
181Abnormality of the costochondral junction (HP:0000919)1.75433466
182Pathologic fracture (HP:0002756)1.75036349
183Esophageal varix (HP:0002040)1.74532412
184Biliary tract neoplasm (HP:0100574)1.73692830
185Rickets (HP:0002748)1.73486380
186Hypokalemia (HP:0002900)1.73133408
187Muscle fibrillation (HP:0010546)1.72851608
188Abnormality of sodium homeostasis (HP:0010931)1.72716734
189Tongue fasciculations (HP:0001308)1.70717543
190Nephrocalcinosis (HP:0000121)1.68244881
191Vascular calcification (HP:0004934)1.66309102

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.59992309
2MST42.85825639
3BUB12.78862303
4CSK2.69312044
5IRAK42.51494879
6CDK122.48316428
7STK102.39688107
8NEK12.34119218
9FGR2.31297328
10WNK32.28334508
11PRPF4B2.12206788
12WNK42.11221649
13WEE12.06122623
14TSSK62.00683399
15TTK1.94691452
16FES1.94510471
17PAK41.89491856
18CDC71.89382929
19EIF2AK11.80163465
20ERN11.76904780
21JAK31.75444032
22TXK1.71655932
23FLT31.70419399
24PDK21.68649077
25NME21.67319488
26MAP3K131.66601369
27IKBKE1.66302453
28SYK1.60364996
29CSF1R1.58540346
30TGFBR21.56848436
31RPS6KB21.55756603
32TAOK31.55228809
33MAP3K81.52219860
34GRK61.51899044
35TESK21.49262535
36TAOK11.46016157
37TYK21.45473103
38STK38L1.43751509
39JAK11.43330469
40MATK1.41728565
41CDK71.41600327
42TNK21.40603859
43LYN1.40213394
44TGFBR11.39801749
45MAPKAPK31.39020929
46BCKDK1.35774061
47MAP2K21.33749243
48GRK71.31295101
49PIK3CG1.30301286
50KDR1.30260418
51OXSR11.29797948
52FRK1.27571040
53BMPR21.27121275
54HCK1.26962351
55MAP3K11.24347773
56LRRK21.24178659
57PIM11.23392052
58NEK21.23328888
59MAP2K31.21386317
60PRKCI1.21078471
61JAK21.18379187
62PRKG21.17228378
63EPHB11.16792489
64MAP3K101.12135967
65KIT1.10304633
66IRAK31.09517930
67CDC42BPA1.08468100
68LCK1.07261359
69MAP3K31.06946718
70MAP4K11.05594880
71MAP3K111.03595402
72TAOK21.02783087
73PKN21.02273623
74MAP3K141.01962698
75PIM21.01178198
76SCYL21.00506884
77MARK30.99690706
78PDPK10.99251668
79SIK30.97551045
80PDK10.95238333
81PLK10.93428165
82TLK10.91984384
83AURKB0.91129024
84IRAK10.88715263
85TESK10.86308807
86ITK0.84231924
87EIF2AK30.83631978
88VRK10.82919326
89BLK0.80690820
90CDK60.79597918
91AURKA0.79518191
92ABL20.77674920
93PTK20.77130751
94IRAK20.75409336
95MET0.73677522
96ACVR1B0.73347255
97DDR20.72888006
98TEC0.71953431
99LMTK20.71649388
100CDK40.71019341
101STK40.70637671
102ATR0.70028570
103PTK60.69488410
104RIPK40.68024687
105EEF2K0.67944012
106YES10.67520088
107ALK0.65965161
108MST1R0.64346637
109CAMKK20.64148939
110MAP3K50.63382182
111PDK40.62798149
112PDK30.62798149
113MAPK70.62606526
114RIPK10.61804765
115DAPK20.61283126
116PLK30.61117289
117CDK190.59437449
118BRSK20.57896104
119LATS20.57696989
120ADRBK20.57619943
121FGFR40.57271034
122FYN0.55284239
123BRD40.55022233
124CHUK0.54846981
125RPS6KA40.54314057
126MAPK120.52609192
127PRKCQ0.51150097
128MTOR0.50508216
129PAK10.50405468
130AKT30.48814668
131MOS0.48792944
132MAP2K60.46823609
133NEK90.46527538
134EPHA30.45991997
135TBK10.45089774
136FGFR30.44512846
137MARK20.44011818
138PASK0.43828006
139KSR20.42700085
140PLK40.42699879
141MELK0.42556989
142CHEK20.41711424
143IKBKB0.41612781
144CHEK10.41471530
145CSNK2A20.41102632
146MAP3K20.40558681
147PRKD20.39211189
148NME10.37945777
149BTK0.36753700
150NLK0.36202123
151ATM0.35260220
152ABL10.34970943
153PRKCD0.33991758
154RPS6KC10.33162186
155RPS6KL10.33162186
156STK240.32893468
157ZAP700.32814083
158SGK30.31862789
159CDK20.31165554
160DYRK1B0.31013719
161PRKCZ0.28643892
162CAMK1D0.27709908
163RPS6KA60.27163803
164EGFR0.25678204
165ARAF0.24651493

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.03972767
2DNA replication_Homo sapiens_hsa030302.74498385
3Allograft rejection_Homo sapiens_hsa053302.72544884
4Osteoclast differentiation_Homo sapiens_hsa043802.68150742
5Graft-versus-host disease_Homo sapiens_hsa053322.62323949
6Vitamin digestion and absorption_Homo sapiens_hsa049772.62290093
7Renin-angiotensin system_Homo sapiens_hsa046142.55464851
8Autoimmune thyroid disease_Homo sapiens_hsa053202.42110422
9Asthma_Homo sapiens_hsa053102.36355738
10Folate biosynthesis_Homo sapiens_hsa007902.36088101
11Mismatch repair_Homo sapiens_hsa034302.35673598
12One carbon pool by folate_Homo sapiens_hsa006702.20982816
13Tuberculosis_Homo sapiens_hsa051522.19092048
14Fat digestion and absorption_Homo sapiens_hsa049752.13502087
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.12539803
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11204860
17Mineral absorption_Homo sapiens_hsa049782.10281715
18Rheumatoid arthritis_Homo sapiens_hsa053232.06427170
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05892071
20Type I diabetes mellitus_Homo sapiens_hsa049402.00328754
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98574628
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96483962
23Ribosome_Homo sapiens_hsa030101.95591872
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93514867
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81391566
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72732915
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71927731
28Other glycan degradation_Homo sapiens_hsa005111.67461710
29Phagosome_Homo sapiens_hsa041451.67222614
30Glutathione metabolism_Homo sapiens_hsa004801.65467341
31B cell receptor signaling pathway_Homo sapiens_hsa046621.59690876
32Malaria_Homo sapiens_hsa051441.57322647
33RNA polymerase_Homo sapiens_hsa030201.56179985
34RNA transport_Homo sapiens_hsa030131.56029376
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55927696
36Pertussis_Homo sapiens_hsa051331.55535488
37Proteasome_Homo sapiens_hsa030501.54789915
38Fructose and mannose metabolism_Homo sapiens_hsa000511.52943125
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49424991
40Toxoplasmosis_Homo sapiens_hsa051451.49064063
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48036117
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45498854
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44530048
44Pyrimidine metabolism_Homo sapiens_hsa002401.42534030
45Base excision repair_Homo sapiens_hsa034101.39677155
46Galactose metabolism_Homo sapiens_hsa000521.37520194
47Spliceosome_Homo sapiens_hsa030401.37329835
48Viral myocarditis_Homo sapiens_hsa054161.37113963
49Chemokine signaling pathway_Homo sapiens_hsa040621.35125483
50Carbon metabolism_Homo sapiens_hsa012001.32741787
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31007799
52TNF signaling pathway_Homo sapiens_hsa046681.30204431
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29919574
54Pyruvate metabolism_Homo sapiens_hsa006201.29123732
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.28422265
56African trypanosomiasis_Homo sapiens_hsa051431.26322057
57Biosynthesis of amino acids_Homo sapiens_hsa012301.25939591
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24234614
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23616059
60Selenocompound metabolism_Homo sapiens_hsa004501.22788731
61Primary immunodeficiency_Homo sapiens_hsa053401.21281492
62Homologous recombination_Homo sapiens_hsa034401.16419808
63Arginine and proline metabolism_Homo sapiens_hsa003301.14235350
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11457407
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.09955268
66Salmonella infection_Homo sapiens_hsa051321.09298256
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07949333
68Starch and sucrose metabolism_Homo sapiens_hsa005001.07913613
69* Protein digestion and absorption_Homo sapiens_hsa049741.06392047
70Measles_Homo sapiens_hsa051621.02744600
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99959790
72Nucleotide excision repair_Homo sapiens_hsa034200.99618551
73Legionellosis_Homo sapiens_hsa051340.99519595
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98972355
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98099469
76Complement and coagulation cascades_Homo sapiens_hsa046100.98092553
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96013803
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95957857
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95517527
80Collecting duct acid secretion_Homo sapiens_hsa049660.92571479
81Bile secretion_Homo sapiens_hsa049760.92044877
82Cell cycle_Homo sapiens_hsa041100.91833212
83Antigen processing and presentation_Homo sapiens_hsa046120.91759931
84Tryptophan metabolism_Homo sapiens_hsa003800.91637653
85Pentose phosphate pathway_Homo sapiens_hsa000300.88752199
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.88194140
87p53 signaling pathway_Homo sapiens_hsa041150.88013166
88Thyroid cancer_Homo sapiens_hsa052160.87399851
89T cell receptor signaling pathway_Homo sapiens_hsa046600.87029832
90Non-homologous end-joining_Homo sapiens_hsa034500.86008668
91Fatty acid degradation_Homo sapiens_hsa000710.79985049
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.79370955
93Acute myeloid leukemia_Homo sapiens_hsa052210.77811958
94Sphingolipid metabolism_Homo sapiens_hsa006000.77520180
95Lysosome_Homo sapiens_hsa041420.76889444
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74417910
97Caffeine metabolism_Homo sapiens_hsa002320.70588703
98Histidine metabolism_Homo sapiens_hsa003400.69839014
99Platelet activation_Homo sapiens_hsa046110.67745797
100Hepatitis B_Homo sapiens_hsa051610.66989835
101Peroxisome_Homo sapiens_hsa041460.65380176
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65224848
103Bladder cancer_Homo sapiens_hsa052190.64887020
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64664319
105Staphylococcus aureus infection_Homo sapiens_hsa051500.64571003
106Lysine degradation_Homo sapiens_hsa003100.63852641
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63211281
108Arginine biosynthesis_Homo sapiens_hsa002200.62864102
109Apoptosis_Homo sapiens_hsa042100.62045265
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61690685
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60377679
112Amoebiasis_Homo sapiens_hsa051460.60315594
113Epstein-Barr virus infection_Homo sapiens_hsa051690.58629108
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58601214
115Propanoate metabolism_Homo sapiens_hsa006400.58088444
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57829170
117Glycerolipid metabolism_Homo sapiens_hsa005610.56020928
118beta-Alanine metabolism_Homo sapiens_hsa004100.55976804
119Arachidonic acid metabolism_Homo sapiens_hsa005900.55571962
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50758597
121Leishmaniasis_Homo sapiens_hsa051400.49646839
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.48446558
123Ether lipid metabolism_Homo sapiens_hsa005650.48112095
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.47913071
125Purine metabolism_Homo sapiens_hsa002300.47817954
126Adherens junction_Homo sapiens_hsa045200.46874459
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46116113
128Systemic lupus erythematosus_Homo sapiens_hsa053220.45894192
129Viral carcinogenesis_Homo sapiens_hsa052030.44780443
130Endocytosis_Homo sapiens_hsa041440.43172797
131PPAR signaling pathway_Homo sapiens_hsa033200.42755234
132Shigellosis_Homo sapiens_hsa051310.42258115
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.42129470
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.42105604
135Herpes simplex infection_Homo sapiens_hsa051680.41952055
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41030806
137Influenza A_Homo sapiens_hsa051640.39428179
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39126876
139RNA degradation_Homo sapiens_hsa030180.38182399
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37648683
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.37409780
142Sulfur relay system_Homo sapiens_hsa041220.35698802
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35064246
144HIF-1 signaling pathway_Homo sapiens_hsa040660.34900845
145Hepatitis C_Homo sapiens_hsa051600.33960011
146GnRH signaling pathway_Homo sapiens_hsa049120.33637334
147Hematopoietic cell lineage_Homo sapiens_hsa046400.33377878
148Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33219743
149Primary bile acid biosynthesis_Homo sapiens_hsa001200.33147684
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32716866
151NF-kappa B signaling pathway_Homo sapiens_hsa040640.32577681
152Metabolic pathways_Homo sapiens_hsa011000.32237350
153Prolactin signaling pathway_Homo sapiens_hsa049170.31385493
154Basal transcription factors_Homo sapiens_hsa030220.31303410
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.31258102
156Prion diseases_Homo sapiens_hsa050200.31073382
157Vibrio cholerae infection_Homo sapiens_hsa051100.30309082
158Insulin resistance_Homo sapiens_hsa049310.30083651
159VEGF signaling pathway_Homo sapiens_hsa043700.29993731
160Linoleic acid metabolism_Homo sapiens_hsa005910.27300303
161Sulfur metabolism_Homo sapiens_hsa009200.24990009
162Dorso-ventral axis formation_Homo sapiens_hsa043200.21553057
163Phospholipase D signaling pathway_Homo sapiens_hsa040720.20290481
164Type II diabetes mellitus_Homo sapiens_hsa049300.20262993

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