SLC7A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nodal signaling pathway (GO:0038092)5.38211478
2COPI coating of Golgi vesicle (GO:0048205)5.27849572
3Golgi transport vesicle coating (GO:0048200)5.27849572
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.09709415
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.09709415
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.09709415
7modulation by symbiont of host immune response (GO:0052553)5.09709415
8positive regulation by symbiont of host defense response (GO:0052509)5.09709415
9modulation by symbiont of host defense response (GO:0052031)5.09709415
10lactate metabolic process (GO:0006089)4.56578764
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.13752508
12peptide hormone processing (GO:0016486)4.08954008
13regulation of interferon-beta biosynthetic process (GO:0045357)4.02333399
14macrophage activation involved in immune response (GO:0002281)3.99364919
15protein retention in ER lumen (GO:0006621)3.92300922
16positive regulation of macroautophagy (GO:0016239)3.91040351
17regulation of posttranscriptional gene silencing (GO:0060147)3.82809436
18regulation of gene silencing by miRNA (GO:0060964)3.82809436
19regulation of gene silencing by RNA (GO:0060966)3.82809436
20angiotensin maturation (GO:0002003)3.72301187
21oligosaccharide catabolic process (GO:0009313)3.72132263
22microglial cell activation (GO:0001774)3.64843224
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.64372083
24paraxial mesoderm development (GO:0048339)3.62524674
25intestinal cholesterol absorption (GO:0030299)3.57013310
26transcytosis (GO:0045056)3.53454940
27glycerophospholipid catabolic process (GO:0046475)3.44858939
28positive regulation of response to extracellular stimulus (GO:0032106)3.42518616
29positive regulation of response to nutrient levels (GO:0032109)3.42518616
30bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41318088
31epithelial cell fate commitment (GO:0072148)3.36474418
32response to host immune response (GO:0052572)3.32754779
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32754779
34regulation of cell fate specification (GO:0042659)3.29210106
35production of molecular mediator involved in inflammatory response (GO:0002532)3.26628994
36exocrine pancreas development (GO:0031017)3.22922291
37glandular epithelial cell differentiation (GO:0002067)3.22627477
38positive regulation of regulated secretory pathway (GO:1903307)3.22280478
39chemosensory behavior (GO:0007635)3.21500656
40negative regulation of hormone biosynthetic process (GO:0032353)3.18129369
41sphingolipid catabolic process (GO:0030149)3.18059286
42positive regulation of mast cell activation involved in immune response (GO:0033008)3.16927641
43positive regulation of mast cell degranulation (GO:0043306)3.16927641
44macrophage activation (GO:0042116)3.15518306
45response to peptidoglycan (GO:0032494)3.15238921
46response to dietary excess (GO:0002021)3.14846974
47vitamin A metabolic process (GO:0006776)3.14655224
48positive regulation of gluconeogenesis (GO:0045722)3.12730176
49water-soluble vitamin biosynthetic process (GO:0042364)3.12199138
50neuromuscular process controlling posture (GO:0050884)3.12019055
51respiratory chain complex IV assembly (GO:0008535)3.10574813
52COPII vesicle coating (GO:0048208)3.08726168
53membrane lipid catabolic process (GO:0046466)3.06883233
54positive regulation of glycolytic process (GO:0045821)3.05972334
55zinc ion transmembrane transport (GO:0071577)3.05023973
56positive regulation of interferon-alpha production (GO:0032727)3.03240692
57positive regulation of SMAD protein import into nucleus (GO:0060391)3.02086409
58positive regulation of calcium ion import (GO:0090280)3.01848420
59kidney morphogenesis (GO:0060993)3.01368780
60endocrine pancreas development (GO:0031018)3.00105158
61positive regulation of histone H3-K4 methylation (GO:0051571)3.00023029
62vesicle coating (GO:0006901)2.99547860
63positive regulation of leukocyte degranulation (GO:0043302)2.99471313
64glycolipid catabolic process (GO:0019377)2.99272916
65nitric oxide biosynthetic process (GO:0006809)2.98040492
66neutrophil activation involved in immune response (GO:0002283)2.95694591
67regulation of regulated secretory pathway (GO:1903305)2.94834950
68pteridine-containing compound biosynthetic process (GO:0042559)2.94232861
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93888038
70regulation of interferon-alpha production (GO:0032647)2.93531898
71cardiac left ventricle morphogenesis (GO:0003214)2.93510801
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93406606
73response to host (GO:0075136)2.93406606
74response to host defenses (GO:0052200)2.93406606
75activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.92509288
76response to hepatocyte growth factor (GO:0035728)2.90513306
77cellular response to hepatocyte growth factor stimulus (GO:0035729)2.90513306
78insulin secretion (GO:0030073)2.82468421
79positive regulation of mast cell activation (GO:0033005)2.81941441
80eosinophil chemotaxis (GO:0048245)2.81354890
81protein maturation by protein folding (GO:0022417)2.81120543
82signal peptide processing (GO:0006465)2.81055873
83macroautophagy (GO:0016236)2.80076055
84regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.78424560
85inner ear receptor cell development (GO:0060119)2.78358325
86auditory receptor cell differentiation (GO:0042491)2.77701403
87basic amino acid transport (GO:0015802)2.75310907
88regulation of insulin secretion (GO:0050796)2.73339110
89positive regulation of nuclease activity (GO:0032075)2.72656779
90activin receptor signaling pathway (GO:0032924)2.72381797
91fatty acid homeostasis (GO:0055089)2.71946177
92glucosamine-containing compound catabolic process (GO:1901072)2.71861715
93* L-alpha-amino acid transmembrane transport (GO:1902475)2.71031514
94L-ascorbic acid metabolic process (GO:0019852)2.70068247
95regulation of mast cell degranulation (GO:0043304)2.69954639
96positive regulation of peptide hormone secretion (GO:0090277)2.69279980
97digestion (GO:0007586)2.68600118
98amino sugar catabolic process (GO:0046348)2.67475198
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66940709
100response to lipoprotein particle (GO:0055094)2.66236094
101intestinal absorption (GO:0050892)2.66198420
102cytochrome complex assembly (GO:0017004)2.63421078
103ceramide catabolic process (GO:0046514)2.62737726
104nitric oxide mediated signal transduction (GO:0007263)2.62167693
105regulation of leukocyte degranulation (GO:0043300)2.60489982
106alanine transport (GO:0032328)2.59898222
107positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59889901
108peptide catabolic process (GO:0043171)2.59398778
109regulation of autophagic vacuole assembly (GO:2000785)2.58124712
110positive regulation of peptide secretion (GO:0002793)2.57784772
111sequestering of metal ion (GO:0051238)2.57086650
112transferrin transport (GO:0033572)2.56841255
113adenosine receptor signaling pathway (GO:0001973)2.55746783
114regulation of mast cell activation involved in immune response (GO:0033006)2.55130061
115trivalent inorganic cation transport (GO:0072512)2.54786797
116ferric iron transport (GO:0015682)2.54786797
117zinc ion transport (GO:0006829)2.54517996
118myeloid cell activation involved in immune response (GO:0002275)2.53560898
119protein autoprocessing (GO:0016540)2.53295455
120negative regulation of execution phase of apoptosis (GO:1900118)2.52642874
121nucleoside transmembrane transport (GO:1901642)2.52532699
122cellular zinc ion homeostasis (GO:0006882)2.52286430
123positive regulation of heat generation (GO:0031652)2.51646164
124polarized epithelial cell differentiation (GO:0030859)2.51162362
125glycosphingolipid catabolic process (GO:0046479)2.50824303
126positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.49610744
127regulation of heart rate by cardiac conduction (GO:0086091)2.49505559
128regulation of nuclease activity (GO:0032069)2.48787967
129proline transport (GO:0015824)2.48280090
130interleukin-1-mediated signaling pathway (GO:0070498)2.48069696
131endoplasmic reticulum unfolded protein response (GO:0030968)2.47065165
132negative regulation of gluconeogenesis (GO:0045721)2.45241482
133regulation of peptide hormone secretion (GO:0090276)2.45225237
134regulation of calcium ion import (GO:0090279)2.45087974
135regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.44804039
136respiratory burst (GO:0045730)2.44791628
137positive regulation of insulin secretion (GO:0032024)2.44698296
138negative regulation of hormone metabolic process (GO:0032351)2.44637933
139sphingomyelin metabolic process (GO:0006684)2.44354540
140eosinophil migration (GO:0072677)2.44345122
141I-kappaB phosphorylation (GO:0007252)2.44126171
142nucleoside transport (GO:0015858)2.43948331
143innervation (GO:0060384)2.43872651
144lung-associated mesenchyme development (GO:0060484)2.43847136
145positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.43350557
146ER overload response (GO:0006983)2.42807862
147hydrogen peroxide biosynthetic process (GO:0050665)2.42317843
148G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.41546006
149phagosome maturation (GO:0090382)2.40923704
150cellular response to unfolded protein (GO:0034620)2.40656241
151dorsal/ventral axis specification (GO:0009950)2.40292227
152positive regulation of exocytosis (GO:0045921)2.40146051
153G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.40007012
154regulation of oxidative phosphorylation (GO:0002082)2.39542810
155positive regulation of vesicle fusion (GO:0031340)2.39496191
156atrial cardiac muscle cell action potential (GO:0086014)2.39155654
157cellular response to vitamin D (GO:0071305)2.38887608
158positive regulation of neurotransmitter transport (GO:0051590)2.38261883
159regulation of peptide secretion (GO:0002791)2.38185637
160positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.38142751
161pH reduction (GO:0045851)2.37819602
162membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.37691525
163positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.36523687
164endosome to melanosome transport (GO:0035646)2.36304693
165endosome to pigment granule transport (GO:0043485)2.36304693
166retinol metabolic process (GO:0042572)2.35151156
167negative regulation of androgen receptor signaling pathway (GO:0060766)2.33599967
168negative regulation of bone resorption (GO:0045779)2.32976831
169intracellular pH reduction (GO:0051452)2.32936191
170regulation of beta-amyloid formation (GO:1902003)2.32565055
171negative regulation of interleukin-17 production (GO:0032700)2.31523158
172positive regulation of chemokine biosynthetic process (GO:0045080)2.31175548
173regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30756836
174peptide secretion (GO:0002790)2.28888749
175peptide transport (GO:0015833)2.28437388
176regulation of ARF protein signal transduction (GO:0032012)2.28305772
177cellular response to topologically incorrect protein (GO:0035967)2.28000718
178synaptic vesicle maturation (GO:0016188)2.27930628
179adhesion of symbiont to host cell (GO:0044650)2.27645826
180virion attachment to host cell (GO:0019062)2.27645826
181ER-nucleus signaling pathway (GO:0006984)2.27562196
182peptide hormone secretion (GO:0030072)2.26352079
183regulation of type B pancreatic cell apoptotic process (GO:2000674)2.25787830
184positive regulation of antigen processing and presentation (GO:0002579)2.25751740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.13481328
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.89557733
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.24021451
4NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.12611688
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.07407750
6GATA1_22025678_ChIP-Seq_K562_Human3.01234716
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93680628
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.59672232
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57693266
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52041409
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42490322
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.27601278
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24655504
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.17043592
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.05814069
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.04970483
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04306312
18SPI1_23127762_ChIP-Seq_K562_Human2.00685110
19TFEB_21752829_ChIP-Seq_HELA_Human1.98502244
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96500890
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83329867
22TCF3_18692474_ChIP-Seq_MEFs_Mouse1.81803956
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81172542
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77500930
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75765777
26HTT_18923047_ChIP-ChIP_STHdh_Human1.69102085
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64935265
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63399137
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63344561
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62705319
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61976435
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57391368
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55800879
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53799352
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52814366
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52640476
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52640476
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52640476
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51966552
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.51943866
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.50329933
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50049356
43FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49778064
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.48702179
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48637546
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46553417
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45546839
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45399694
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.44794416
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.44313853
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40867491
52* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40667981
53TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39986564
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.39727320
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37377748
56* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36196727
57DROSHA_22980978_ChIP-Seq_HELA_Human1.35720694
58* GATA1_19941826_ChIP-Seq_K562_Human1.34193293
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33907631
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31878275
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30468504
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28777974
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27821277
64LXR_22292898_ChIP-Seq_THP-1_Human1.27216801
65P300_19829295_ChIP-Seq_ESCs_Human1.24975252
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24864316
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22851484
68VDR_24787735_ChIP-Seq_THP-1_Human1.22829509
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.22190989
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21896655
71* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19935035
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.19322091
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19184956
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19175285
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.17946587
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17895714
77REST_21632747_ChIP-Seq_MESCs_Mouse1.17609187
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16883099
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16651998
80* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13950615
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13628689
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13475138
83SMAD3_21741376_ChIP-Seq_HESCs_Human1.12419152
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12252010
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12154097
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11508062
87* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10917021
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.10572151
89* SOX2_20726797_ChIP-Seq_SW620_Human1.10277177
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10084045
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09841586
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09451252
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08591903
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08191639
95* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07139768
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.06712049
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05286410
98PU_27001747_Chip-Seq_BMDM_Mouse1.05259722
99PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04585768
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04156284
101* GATA2_19941826_ChIP-Seq_K562_Human1.03736257
102VDR_24763502_ChIP-Seq_THP-1_Human1.03561452
103* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03510571
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.03366512
105CDX2_22108803_ChIP-Seq_LS180_Human1.03210250
106* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03154548
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03138102
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02851682
109PHF8_20622853_ChIP-Seq_HELA_Human1.01013274
110CLOCK_20551151_ChIP-Seq_293T_Human1.00417902
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00104341
112TCF7_22412390_ChIP-Seq_EML_Mouse0.99918381
113HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99125440
114GATA3_27048872_Chip-Seq_THYMUS_Human0.98557422
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98206151
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98101296
117KDM2B_26808549_Chip-Seq_K562_Human0.97996340
118REST_18959480_ChIP-ChIP_MESCs_Mouse0.97681969
119* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97609532
120* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97453358
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96759713
122TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96536670
123TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96508598
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.96416935
125* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96120472
126* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95580933
127SMAD4_21799915_ChIP-Seq_A2780_Human0.95426040
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95188277
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95188277
130CHD1_26751641_Chip-Seq_LNCaP_Human0.94897035
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94730260
132* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94658340
133ZNF263_19887448_ChIP-Seq_K562_Human0.94425477
134PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94091556
135KAP1_27257070_Chip-Seq_ESCs_Mouse0.93651714
136BCAT_22108803_ChIP-Seq_LS180_Human0.93400326
137RUNX_20019798_ChIP-Seq_JUKART_Human0.93075723
138RBPJ_21746931_ChIP-Seq_IB4_Human0.92680274
139* SCL_19346495_ChIP-Seq_HPC-7_Human0.92245906
140STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92022097
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91143397
142* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90753422
143KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89903403
144TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89858964
145* RUNX1_22412390_ChIP-Seq_EML_Mouse0.89477042
146CDX2_20551321_ChIP-Seq_CACO-2_Human0.89177994
147GATA3_26560356_Chip-Seq_TH2_Human0.89095561
148* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88925335
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.88559806
150WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88437114
151CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88386615
152NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88123736
153SOX17_20123909_ChIP-Seq_XEN_Mouse0.88003629
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87765341
155* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87361795
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86905376
157CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86769098
158E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86056495
159PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85090097
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.84852653
161PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84194394
162DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83284223
163SPI1_23547873_ChIP-Seq_NB4_Human0.82771867
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82450987
165LXR_22158963_ChIP-Seq_LIVER_Mouse0.82328200
166* FOXA2_19822575_ChIP-Seq_HepG2_Human0.81869245
167RXR_22158963_ChIP-Seq_LIVER_Mouse0.79904943
168PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79890205
169TET1_21490601_ChIP-Seq_MESCs_Mouse0.79304960
170SOX2_18555785_Chip-Seq_ESCs_Mouse0.79179271
171EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79055270
172TBL1_22424771_ChIP-Seq_293T_Human0.78948435
173MYCN_18555785_ChIP-Seq_MESCs_Mouse0.78919114
174TCF4_22108803_ChIP-Seq_LS180_Human0.78839487
175KDM2B_26808549_Chip-Seq_DND41_Human0.78438392
176* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78259756
177FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77516709
178* GATA4_25053715_ChIP-Seq_YYC3_Human0.77173302
179TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76684639
180* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.76242436
181PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74924337
182SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74817860
183FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.72853416
184AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72806259
185EGR1_19032775_ChIP-ChIP_M12_Human0.72266611
186GATA6_25053715_ChIP-Seq_YYC3_Human0.72008033
187STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71917436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.09543350
2MP0005058_abnormal_lysosome_morphology4.28963913
3MP0003183_abnormal_peptide_metabolism4.26713112
4MP0003172_abnormal_lysosome_physiology3.88903147
5MP0010234_abnormal_vibrissa_follicle3.76123586
6MP0002837_dystrophic_cardiac_calcinosis3.65825449
7MP0003303_peritoneal_inflammation3.06183749
8MP0003300_gastrointestinal_ulcer2.87568042
9MP0003195_calcinosis2.80951530
10MP0003941_abnormal_skin_development2.78937941
11MP0002693_abnormal_pancreas_physiology2.68794688
12MP0004043_abnormal_pH_regulation2.67109155
13MP0008877_abnormal_DNA_methylation2.63314593
14MP0002909_abnormal_adrenal_gland2.57047263
15MP0003787_abnormal_imprinting2.56632649
16MP0006082_CNS_inflammation2.54795331
17MP0003011_delayed_dark_adaptation2.45447783
18MP0010386_abnormal_urinary_bladder2.36710593
19MP0009780_abnormal_chondrocyte_physiolo2.28340262
20MP0002877_abnormal_melanocyte_morpholog2.28174106
21MP0003136_yellow_coat_color2.22587016
22MP0003436_decreased_susceptibility_to2.17076726
23MP0003122_maternal_imprinting2.16641464
24MP0003123_paternal_imprinting2.07793673
25MP0003878_abnormal_ear_physiology2.07678976
26MP0005377_hearing/vestibular/ear_phenot2.07678976
27MP0002938_white_spotting2.05675703
28MP0001666_abnormal_nutrient_absorption2.04217495
29MP0000013_abnormal_adipose_tissue2.02542399
30MP0000372_irregular_coat_pigmentation1.94837592
31MP0009840_abnormal_foam_cell1.94657112
32MP0009672_abnormal_birth_weight1.91349496
33MP0004510_myositis1.88393105
34MP0005310_abnormal_salivary_gland1.81036017
35MP0002419_abnormal_innate_immunity1.80576752
36MP0004858_abnormal_nervous_system1.80054914
37MP0005075_abnormal_melanosome_morpholog1.77970055
38MP0001835_abnormal_antigen_presentation1.76289402
39MP0003191_abnormal_cellular_cholesterol1.72987582
40MP0000604_amyloidosis1.72614215
41MP0001944_abnormal_pancreas_morphology1.71392027
42MP0004859_abnormal_synaptic_plasticity1.69697943
43MP0002148_abnormal_hypersensitivity_rea1.68931052
44MP0001765_abnormal_ion_homeostasis1.68442017
45MP0008961_abnormal_basal_metabolism1.68370026
46MP0010352_gastrointestinal_tract_polyps1.66307360
47MP0000579_abnormal_nail_morphology1.63070824
48MP0005000_abnormal_immune_tolerance1.60850597
49MP0003075_altered_response_to1.60685243
50MP0000569_abnormal_digit_pigmentation1.60040878
51MP0006072_abnormal_retinal_apoptosis1.56939439
52MP0003890_abnormal_embryonic-extraembry1.54917002
53MP0002139_abnormal_hepatobiliary_system1.54343726
54MP0001533_abnormal_skeleton_physiology1.54286612
55MP0005379_endocrine/exocrine_gland_phen1.53508365
56MP0003283_abnormal_digestive_organ1.52461682
57MP0005220_abnormal_exocrine_pancreas1.51229837
58MP0005464_abnormal_platelet_physiology1.49641598
59MP0005083_abnormal_biliary_tract1.48758762
60MP0004264_abnormal_extraembryonic_tissu1.45400674
61MP0002796_impaired_skin_barrier1.44366472
62MP0004270_analgesia1.44281666
63MP0002163_abnormal_gland_morphology1.41310533
64MP0001790_abnormal_immune_system1.38965362
65MP0005387_immune_system_phenotype1.38965362
66MP0002078_abnormal_glucose_homeostasis1.38157259
67MP0001756_abnormal_urination1.34973732
68MP0000015_abnormal_ear_pigmentation1.34564928
69MP0005174_abnormal_tail_pigmentation1.30462032
70MP0009643_abnormal_urine_homeostasis1.29907205
71MP0002295_abnormal_pulmonary_circulatio1.29330451
72MP0004947_skin_inflammation1.28186103
73MP0005671_abnormal_response_to1.26346223
74MP0003690_abnormal_glial_cell1.25098186
75MP0001845_abnormal_inflammatory_respons1.22900813
76MP0005535_abnormal_body_temperature1.22824245
77MP0003045_fibrosis1.22824107
78MP0003718_maternal_effect1.21322088
79MP0003121_genomic_imprinting1.20633799
80MP0005025_abnormal_response_to1.20423124
81MP0005248_abnormal_Harderian_gland1.20318097
82MP0005332_abnormal_amino_acid1.19148505
83MP0008469_abnormal_protein_level1.19065604
84MP0003879_abnormal_hair_cell1.19018699
85MP0002998_abnormal_bone_remodeling1.15656431
86MP0005645_abnormal_hypothalamus_physiol1.14199316
87MP0001501_abnormal_sleep_pattern1.13826392
88MP0000003_abnormal_adipose_tissue1.13759571
89MP0002723_abnormal_immune_serum1.13334240
90MP0005408_hypopigmentation1.12782464
91MP0010678_abnormal_skin_adnexa1.11234005
92MP0005084_abnormal_gallbladder_morpholo1.09971374
93MP0009785_altered_susceptibility_to1.08286400
94MP0004885_abnormal_endolymph1.08043101
95MP0004133_heterotaxia1.07202027
96MP0002928_abnormal_bile_duct1.07132396
97MP0002452_abnormal_antigen_presenting1.07006896
98MP0005257_abnormal_intraocular_pressure1.06907370
99MP0005448_abnormal_energy_balance1.04790807
100MP0005365_abnormal_bile_salt1.03780451
101MP0010329_abnormal_lipoprotein_level1.03465029
102MP0010307_abnormal_tumor_latency1.02180568
103MP0004019_abnormal_vitamin_homeostasis1.00895088
104MP0001984_abnormal_olfaction1.00280636
105MP0000647_abnormal_sebaceous_gland0.99358520
106MP0000371_diluted_coat_color0.98494007
107MP0002090_abnormal_vision0.96863530
108MP0000462_abnormal_digestive_system0.96498334
109MP0009703_decreased_birth_body0.96367859
110MP0005167_abnormal_blood-brain_barrier0.96176973
111MP0005166_decreased_susceptibility_to0.95973116
112MP0005253_abnormal_eye_physiology0.93471549
113MP0001849_ear_inflammation0.93096063
114MP0003633_abnormal_nervous_system0.92393008
115MP0003866_abnormal_defecation0.91771597
116MP0001819_abnormal_immune_cell0.91605760
117MP0003953_abnormal_hormone_level0.91502731
118MP0002420_abnormal_adaptive_immunity0.88752347
119MP0002138_abnormal_hepatobiliary_system0.88021990
120MP0002733_abnormal_thermal_nociception0.87144050
121MP0001324_abnormal_eye_pigmentation0.87031439
122MP0005409_darkened_coat_color0.87011883
123MP0003724_increased_susceptibility_to0.86728796
124MP0000377_abnormal_hair_follicle0.86629193
125MP0003252_abnormal_bile_duct0.86336429
126MP0000538_abnormal_urinary_bladder0.84544203
127MP0005636_abnormal_mineral_homeostasis0.83813807
128MP0000343_altered_response_to0.83432391
129MP0001800_abnormal_humoral_immune0.83371111
130MP0002896_abnormal_bone_mineralization0.83177122
131MP0001485_abnormal_pinna_reflex0.82152845
132* MP0002064_seizures0.82043325
133MP0000678_abnormal_parathyroid_gland0.80589350
134MP0002136_abnormal_kidney_physiology0.79448190
135MP0001188_hyperpigmentation0.78952478
136MP0000230_abnormal_systemic_arterial0.78550163
137MP0009046_muscle_twitch0.78322018
138MP0003638_abnormal_response/metabolism_0.78068900
139MP0002638_abnormal_pupillary_reflex0.76876463
140MP0001299_abnormal_eye_distance/0.75868406
141MP0002229_neurodegeneration0.75575185
142MP0003795_abnormal_bone_structure0.74393545
143MP0000516_abnormal_urinary_system0.74316688
144MP0005367_renal/urinary_system_phenotyp0.74316688
145MP0001970_abnormal_pain_threshold0.73854112
146MP0003635_abnormal_synaptic_transmissio0.73722712
147MP0001986_abnormal_taste_sensitivity0.73710871
148MP0010155_abnormal_intestine_physiology0.72425776
149MP0003329_amyloid_beta_deposits0.71703606
150MP0003634_abnormal_glial_cell0.71512699
151MP0004272_abnormal_basement_membrane0.71039458
152MP0001664_abnormal_digestion0.70657150
153MP0002734_abnormal_mechanical_nocicepti0.70256811
154MP0002075_abnormal_coat/hair_pigmentati0.69714987
155MP0002876_abnormal_thyroid_physiology0.69706493
156MP0008004_abnormal_stomach_pH0.69657590
157MP0002118_abnormal_lipid_homeostasis0.68214484
158MP0003186_abnormal_redox_activity0.68001141
159MP0001186_pigmentation_phenotype0.62724748
160MP0001661_extended_life_span0.62683214
161MP0000566_synostosis0.61182777
162MP0002060_abnormal_skin_morphology0.56386299
163MP0005646_abnormal_pituitary_gland0.56195274
164MP0005551_abnormal_eye_electrophysiolog0.53174940
165MP0000631_abnormal_neuroendocrine_gland0.51643198
166MP0002277_abnormal_respiratory_mucosa0.51497016
167MP0001730_embryonic_growth_arrest0.51453219
168MP0002069_abnormal_eating/drinking_beha0.51408003

Predicted human phenotypes

RankGene SetZ-score
1Dysostosis multiplex (HP:0000943)5.33413714
2Increased cerebral lipofuscin (HP:0011813)5.08062743
3Mucopolysacchariduria (HP:0008155)4.76615680
4Urinary glycosaminoglycan excretion (HP:0003541)4.76615680
5Abnormality of mucopolysaccharide metabolism (HP:0011020)4.54720528
6Abnormality of polysaccharide metabolism (HP:0011012)4.54720528
7Abnormality of glycosaminoglycan metabolism (HP:0004371)4.54720528
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.54547226
9Vacuolated lymphocytes (HP:0001922)4.53776719
10Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.48236200
11Abnormality of glycolipid metabolism (HP:0010969)4.47514601
12Abnormality of liposaccharide metabolism (HP:0010968)4.47514601
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.47514601
14Systemic lupus erythematosus (HP:0002725)4.28380106
15Nuclear cataract (HP:0100018)4.17693969
16Retinal atrophy (HP:0001105)3.99517330
17Hyperinsulinemic hypoglycemia (HP:0000825)3.61489677
18Recurrent abscess formation (HP:0002722)3.59130691
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.53416818
20Hypoglycemic seizures (HP:0002173)3.50821835
21Recurrent bacterial skin infections (HP:0005406)3.34641599
22Symptomatic seizures (HP:0011145)3.32263467
23Enlarged penis (HP:0000040)3.27119947
24Hypomagnesemia (HP:0002917)3.02707722
25Abnormality of calcium-phosphate metabolism (HP:0100530)2.90569222
26Eczematoid dermatitis (HP:0000976)2.82756111
27Glomerulonephritis (HP:0000099)2.82362419
28Aplasia/Hypoplasia of the fovea (HP:0008060)2.80906219
29Hypoplasia of the fovea (HP:0007750)2.80906219
30Abnormality of macrophages (HP:0004311)2.73781445
31Agitation (HP:0000713)2.70026202
32Ketoacidosis (HP:0001993)2.66717619
33Congenital malformation of the right heart (HP:0011723)2.66632989
34Double outlet right ventricle (HP:0001719)2.66632989
35Hypoglycemic coma (HP:0001325)2.66572991
36Hepatoblastoma (HP:0002884)2.62617696
37Axonal loss (HP:0003447)2.61291378
38Late onset (HP:0003584)2.55374857
39Mutism (HP:0002300)2.55100714
40Abnormality of magnesium homeostasis (HP:0004921)2.54570813
41Abnormality of the labia minora (HP:0012880)2.52865109
42Decreased circulating renin level (HP:0003351)2.50233316
43Supranuclear gaze palsy (HP:0000605)2.50094612
44Increased circulating renin level (HP:0000848)2.47943783
45Abnormality of the fovea (HP:0000493)2.46220900
46Recurrent gram-negative bacterial infections (HP:0005420)2.43844991
47Prominent metopic ridge (HP:0005487)2.43729332
48Papilledema (HP:0001085)2.41154045
49Progressive neurologic deterioration (HP:0002344)2.40752977
50Intestinal atresia (HP:0011100)2.40620376
51Disinhibition (HP:0000734)2.37053543
52Neuronal loss in central nervous system (HP:0002529)2.36769693
53Hematochezia (HP:0002573)2.34036577
54Hyperglycemia (HP:0003074)2.33719855
55Ketosis (HP:0001946)2.31692423
56Insulin-resistant diabetes mellitus (HP:0000831)2.30199375
57Progressive visual loss (HP:0000529)2.29527429
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27273584
59Abnormality of chloride homeostasis (HP:0011422)2.26909729
60Increased CSF protein (HP:0002922)2.25257050
61Large for gestational age (HP:0001520)2.24490736
62Hyperactive renin-angiotensin system (HP:0000841)2.24031856
63Hypokalemia (HP:0002900)2.23825048
64Abnormality of renin-angiotensin system (HP:0000847)2.23364299
65Hypophosphatemia (HP:0002148)2.22721045
66Autoimmune thrombocytopenia (HP:0001973)2.21760805
67Abnormality of abdominal situs (HP:0011620)2.16976676
68Abdominal situs inversus (HP:0003363)2.16976676
69Gingivitis (HP:0000230)2.14425349
70Abnormality of the metopic suture (HP:0005556)2.14423526
71Visual hallucinations (HP:0002367)2.13706301
72Hypokinesia (HP:0002375)2.12380930
73Loss of speech (HP:0002371)2.11446661
74Global brain atrophy (HP:0002283)2.10725285
75Urethral obstruction (HP:0000796)2.10631374
76Abnormality of endocrine pancreas physiology (HP:0012093)2.09014165
77Abnormality of the pancreatic islet cells (HP:0006476)2.09014165
78Hyperparathyroidism (HP:0000843)2.08218623
79Aqueductal stenosis (HP:0002410)2.08147076
80Hypothermia (HP:0002045)2.06684864
81Pathologic fracture (HP:0002756)2.05541745
82Gout (HP:0001997)2.04718919
83Restlessness (HP:0000711)2.03417542
84Aplasia/Hypoplasia of the macula (HP:0008059)2.03352139
85EEG with generalized epileptiform discharges (HP:0011198)2.00776288
86Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.95512518
87Right ventricular cardiomyopathy (HP:0011663)1.94588949
88Proximal tubulopathy (HP:0000114)1.93007992
89Epileptiform EEG discharges (HP:0011182)1.92117864
90Apathy (HP:0000741)1.91702259
91Asymmetric septal hypertrophy (HP:0001670)1.90576288
92Hyperphosphatemia (HP:0002905)1.89689069
93Metabolic alkalosis (HP:0200114)1.89166703
94Pancreatic islet-cell hyperplasia (HP:0004510)1.88918647
95White forelock (HP:0002211)1.88642955
96Hypotension (HP:0002615)1.88280132
97Abnormality of potassium homeostasis (HP:0011042)1.87456135
98Tetany (HP:0001281)1.87318706
99Albinism (HP:0001022)1.87096566
100Basal ganglia calcification (HP:0002135)1.86974507
101Hypsarrhythmia (HP:0002521)1.85820035
102Neurofibrillary tangles (HP:0002185)1.85796364
103Hypokalemic alkalosis (HP:0001949)1.85312172
104Dysautonomia (HP:0002459)1.84982585
105Aplasia/Hypoplasia affecting the retina (HP:0008061)1.83574149
106Abnormality of vitamin B metabolism (HP:0004340)1.83154049
107Zonular cataract (HP:0010920)1.82606590
108Diminished motivation (HP:0000745)1.82480832
109Patchy hypopigmentation of hair (HP:0011365)1.81647522
110Labial hypoplasia (HP:0000066)1.79188833
111Dementia (HP:0000726)1.78880536
112Protuberant abdomen (HP:0001538)1.78236284
113Abnormality of vitamin metabolism (HP:0100508)1.78042178
114Cardiomegaly (HP:0001640)1.76803117
115Iris hypopigmentation (HP:0007730)1.76605400
116Generalized hypopigmentation (HP:0007513)1.76460225
117Metaphyseal irregularity (HP:0003025)1.75897023
118Conjugated hyperbilirubinemia (HP:0002908)1.75781198
119Abnormality of binocular vision (HP:0011514)1.75547576
120Diplopia (HP:0000651)1.75547576
121Orthostatic hypotension (HP:0001278)1.74903915
122Abnormality of the dental root (HP:0006486)1.73486717
123Taurodontia (HP:0000679)1.73486717
124Abnormality of permanent molar morphology (HP:0011071)1.73486717
125Postural tremor (HP:0002174)1.72888183
126Congenital sensorineural hearing impairment (HP:0008527)1.72783723
127Fatigue (HP:0012378)1.71966190
128Hand muscle atrophy (HP:0009130)1.71959462
129Agnosia (HP:0010524)1.71436067
130J-shaped sella turcica (HP:0002680)1.69088804
131Hypogonadotrophic hypogonadism (HP:0000044)1.68247700
132Abnormal pancreas size (HP:0012094)1.68230387
133Abdominal distention (HP:0003270)1.67871983
134Tongue fasciculations (HP:0001308)1.67285702
135Abnormality of purine metabolism (HP:0004352)1.66996802
136Peripheral demyelination (HP:0011096)1.66481835
137Abnormality of molar (HP:0011077)1.66223690
138Abnormality of molar morphology (HP:0011070)1.66223690
139Striae distensae (HP:0001065)1.65198589
140Hypoplastic female external genitalia (HP:0012815)1.64714346
141Choanal stenosis (HP:0000452)1.64547206
142Abnormality of renal excretion (HP:0011036)1.64292909
143Bone pain (HP:0002653)1.63847339
144Recurrent skin infections (HP:0001581)1.63411185
145Exocrine pancreatic insufficiency (HP:0001738)1.63012759
146Cerebral inclusion bodies (HP:0100314)1.62597306
147Complement deficiency (HP:0004431)1.62511719
148Tetraparesis (HP:0002273)1.62411408
149Insulin resistance (HP:0000855)1.62382457
150Interstitial pulmonary disease (HP:0006530)1.61165071
151Polydipsia (HP:0001959)1.60902466
152Abnormal drinking behavior (HP:0030082)1.60902466
153Short hallux (HP:0010109)1.60566083
154Abnormal urine output (HP:0012590)1.60557528
155Hyperaldosteronism (HP:0000859)1.60244638
156Ependymoma (HP:0002888)1.60156395
157Woolly hair (HP:0002224)1.59456730
158Abnormality of the dental pulp (HP:0006479)1.59070888
159Adrenal overactivity (HP:0002717)1.58850027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.41090257
2ERN13.91111655
3FGFR23.88661662
4TAOK33.46079049
5INSRR3.42411395
6MST43.38818294
7WNK32.98367920
8TNIK2.89653681
9RIPK42.79695538
10STK242.71894393
11IRAK32.57480713
12WNK42.48954218
13PIK3CG2.46567396
14STK32.33772237
15NLK2.22341522
16MAP3K22.19981040
17PRKD32.12949792
18FRK2.11647100
19TSSK62.00220057
20TBK11.97824759
21GRK11.96595284
22TTK1.96192967
23STK38L1.93386713
24FER1.92808685
25CAMKK21.91815480
26SCYL21.87426554
27TGFBR21.80552800
28MKNK21.78896161
29MAP3K91.77261808
30CSNK1G11.68380398
31TYK21.65204069
32KSR21.63937343
33MAP3K11.56399743
34PLK31.55214415
35MAP2K61.51201416
36NTRK11.49839567
37ACVR1B1.48634944
38NTRK31.48065208
39HIPK21.47458274
40DAPK21.47166653
41IRAK41.42058306
42MKNK11.40924221
43PHKG21.37312299
44PHKG11.37312299
45CAMKK11.35713981
46JAK11.33747491
47KIT1.31090746
48STK161.25830017
49PTK61.24085154
50TRIB31.23184470
51LATS11.19939253
52PRKCG1.18364911
53FES1.18208276
54ZAP701.17861140
55MAP3K141.16101085
56PAK41.14706606
57CSNK1G21.13804215
58JAK21.13644874
59CSNK1G31.10286778
60CDK121.10227218
61CAMK1G1.06912494
62PRKCH1.04340989
63TRPM70.97748321
64PRKCE0.95939701
65MATK0.95729655
66IKBKE0.95513943
67CAMK1D0.93924099
68PNCK0.93666239
69AKT30.92713888
70MAP3K130.92566401
71EPHB10.89813996
72PAK30.89443264
73YES10.88483845
74CSK0.87193442
75PASK0.86081621
76ADRBK20.83067552
77FGFR10.82231958
78LATS20.81545385
79ZAK0.81357765
80GRK70.80932520
81SYK0.80480229
82RIPK10.79566556
83JAK30.79296723
84STK40.79032077
85CASK0.78779670
86TAOK10.77796222
87WNK10.76387584
88PTK20.74699662
89MAP2K20.74206436
90PRKCI0.73673097
91PDPK10.73071195
92DAPK10.71667959
93FGFR40.69720901
94CAMK2D0.69337035
95TRIM280.67960764
96RET0.66835969
97PAK60.65333142
98PDK10.65023151
99TGFBR10.65020641
100BLK0.64855806
101CSF1R0.63046716
102BMPR20.61616238
103EEF2K0.60270862
104BRAF0.60152481
105EPHA30.60086569
106TIE10.59907625
107MAP4K10.59431780
108CSNK1E0.59209297
109SIK20.58871579
110VRK20.58793272
111SGK30.58296276
112CSNK1A10.58090640
113UHMK10.57785195
114HCK0.56632528
115FLT30.55818520
116CDK30.55151550
117PRKAA20.55148087
118RPS6KA20.53586783
119CSNK1A1L0.53398882
120DMPK0.52054494
121DYRK1B0.51781552
122CDK50.51585625
123EIF2AK30.51037714
124PLK10.50930195
125TAF10.50786883
126ATM0.49715021
127IRAK10.48672287
128MAP4K20.48551584
129NME10.47854432
130LYN0.46686177
131PLK20.45423391
132PRKAA10.45224834
133SGK10.43602449
134MAP3K40.43431844
135PRKDC0.42925352
136STK110.42006543
137PDGFRA0.41782374
138ARAF0.40219246
139CDC42BPA0.39908980
140MAP2K10.39801220
141PINK10.39375711
142LCK0.39140033
143EGFR0.39095399
144ITK0.39093825
145CHUK0.38656615
146BMX0.36836316
147PRKCD0.36571402
148IKBKB0.36206889
149CDC70.35965811
150CSNK1D0.35246519
151MINK10.34935602
152DYRK20.33772352
153SGK20.33490373
154GRK50.33051580
155SGK4940.32873989
156SGK2230.32873989
157IGF1R0.32582332
158PRKD20.32322425
159PRKG20.32050405
160FYN0.31930774
161TXK0.30861381
162OXSR10.30237958
163PRKACB0.29998993
164FGFR30.29617390
165GSK3A0.29490811
166ALK0.29289013
167PRKACG0.28828069
168MAP3K30.28706980
169PKN20.28266337

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.86096109
2Vitamin B6 metabolism_Homo sapiens_hsa007503.35603833
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.75885087
4Lysosome_Homo sapiens_hsa041422.70646917
5Other glycan degradation_Homo sapiens_hsa005112.29430229
6Fatty acid elongation_Homo sapiens_hsa000622.08124436
7Selenocompound metabolism_Homo sapiens_hsa004502.07147804
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.05535861
9Insulin secretion_Homo sapiens_hsa049112.00616806
10Type II diabetes mellitus_Homo sapiens_hsa049301.96758223
11Folate biosynthesis_Homo sapiens_hsa007901.91846438
12Pancreatic secretion_Homo sapiens_hsa049721.86513222
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78508420
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77789820
15Type I diabetes mellitus_Homo sapiens_hsa049401.72894374
16Steroid biosynthesis_Homo sapiens_hsa001001.72688039
17Synaptic vesicle cycle_Homo sapiens_hsa047211.69917520
18Renin-angiotensin system_Homo sapiens_hsa046141.69908237
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66130963
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66009372
21Collecting duct acid secretion_Homo sapiens_hsa049661.62808065
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62291701
23Vibrio cholerae infection_Homo sapiens_hsa051101.60439577
24Oxidative phosphorylation_Homo sapiens_hsa001901.57792647
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50929195
26Butanoate metabolism_Homo sapiens_hsa006501.46410336
27Leishmaniasis_Homo sapiens_hsa051401.43695380
28Staphylococcus aureus infection_Homo sapiens_hsa051501.41914291
29Osteoclast differentiation_Homo sapiens_hsa043801.39289831
30Glutathione metabolism_Homo sapiens_hsa004801.36896756
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31837207
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29790646
33Tuberculosis_Homo sapiens_hsa051521.28984653
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27364001
35Fat digestion and absorption_Homo sapiens_hsa049751.25486431
36Pertussis_Homo sapiens_hsa051331.25159126
37Legionellosis_Homo sapiens_hsa051341.22717102
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21196499
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.20385206
40Rheumatoid arthritis_Homo sapiens_hsa053231.19591452
41Protein export_Homo sapiens_hsa030601.18281984
42Mineral absorption_Homo sapiens_hsa049781.17819026
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15376147
44Ether lipid metabolism_Homo sapiens_hsa005651.10849510
45Prion diseases_Homo sapiens_hsa050201.09087690
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08726782
47Fatty acid metabolism_Homo sapiens_hsa012121.07881848
48Asthma_Homo sapiens_hsa053101.05524065
49Phagosome_Homo sapiens_hsa041451.04080915
50Circadian rhythm_Homo sapiens_hsa047100.99299556
51Cocaine addiction_Homo sapiens_hsa050300.99051237
52* Protein digestion and absorption_Homo sapiens_hsa049740.98675770
53Tryptophan metabolism_Homo sapiens_hsa003800.97457786
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94426265
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94022883
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92368065
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92052044
58Propanoate metabolism_Homo sapiens_hsa006400.91479473
59Tight junction_Homo sapiens_hsa045300.90425015
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89491223
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87864897
62beta-Alanine metabolism_Homo sapiens_hsa004100.87662116
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86918725
64Influenza A_Homo sapiens_hsa051640.84383452
65Glucagon signaling pathway_Homo sapiens_hsa049220.84120604
66N-Glycan biosynthesis_Homo sapiens_hsa005100.82664551
67Amphetamine addiction_Homo sapiens_hsa050310.81943446
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80295251
69Phototransduction_Homo sapiens_hsa047440.79927357
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79635634
71Long-term potentiation_Homo sapiens_hsa047200.78739928
72Salmonella infection_Homo sapiens_hsa051320.77546998
73Circadian entrainment_Homo sapiens_hsa047130.77481104
74Chemokine signaling pathway_Homo sapiens_hsa040620.76850345
75Sphingolipid metabolism_Homo sapiens_hsa006000.76752101
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76374297
77Prolactin signaling pathway_Homo sapiens_hsa049170.75350448
78TNF signaling pathway_Homo sapiens_hsa046680.75174081
79Ovarian steroidogenesis_Homo sapiens_hsa049130.75032686
80Arginine biosynthesis_Homo sapiens_hsa002200.74947409
81B cell receptor signaling pathway_Homo sapiens_hsa046620.73705316
82Renin secretion_Homo sapiens_hsa049240.73652553
83Cholinergic synapse_Homo sapiens_hsa047250.72778168
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.72567472
85Toxoplasmosis_Homo sapiens_hsa051450.71238476
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70746505
87Gastric acid secretion_Homo sapiens_hsa049710.69305334
88Galactose metabolism_Homo sapiens_hsa000520.69206917
89Estrogen signaling pathway_Homo sapiens_hsa049150.67929719
90GABAergic synapse_Homo sapiens_hsa047270.67677581
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66448674
92RNA polymerase_Homo sapiens_hsa030200.66102268
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65496112
94Inositol phosphate metabolism_Homo sapiens_hsa005620.65250182
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64437802
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64258485
97Dopaminergic synapse_Homo sapiens_hsa047280.63989901
98Antigen processing and presentation_Homo sapiens_hsa046120.63897267
99Metabolic pathways_Homo sapiens_hsa011000.62413734
100Sulfur metabolism_Homo sapiens_hsa009200.62411391
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62142367
102Pyruvate metabolism_Homo sapiens_hsa006200.60308502
103Endocytosis_Homo sapiens_hsa041440.59906786
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58656677
105Morphine addiction_Homo sapiens_hsa050320.57907786
106Arginine and proline metabolism_Homo sapiens_hsa003300.57525727
107Vitamin digestion and absorption_Homo sapiens_hsa049770.57129136
108Thyroid hormone synthesis_Homo sapiens_hsa049180.56882430
109Insulin resistance_Homo sapiens_hsa049310.56861799
110Adherens junction_Homo sapiens_hsa045200.56179031
111Fatty acid degradation_Homo sapiens_hsa000710.55976941
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55317168
113Salivary secretion_Homo sapiens_hsa049700.54757486
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.54730404
115ABC transporters_Homo sapiens_hsa020100.54075785
116Basal transcription factors_Homo sapiens_hsa030220.53780248
117Serotonergic synapse_Homo sapiens_hsa047260.53626674
118Peroxisome_Homo sapiens_hsa041460.51881546
119African trypanosomiasis_Homo sapiens_hsa051430.51800448
120Bile secretion_Homo sapiens_hsa049760.51755288
121Dorso-ventral axis formation_Homo sapiens_hsa043200.51733404
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51587493
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.51237651
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50837718
125Starch and sucrose metabolism_Homo sapiens_hsa005000.49595535
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49465900
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48883751
128Hepatitis C_Homo sapiens_hsa051600.48845086
129Alzheimers disease_Homo sapiens_hsa050100.48552518
130Parkinsons disease_Homo sapiens_hsa050120.48308078
131cAMP signaling pathway_Homo sapiens_hsa040240.47394818
132Glioma_Homo sapiens_hsa052140.47353839
133Olfactory transduction_Homo sapiens_hsa047400.47241201
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47155087
135Thyroid cancer_Homo sapiens_hsa052160.46954719
136mTOR signaling pathway_Homo sapiens_hsa041500.46002356
137Amoebiasis_Homo sapiens_hsa051460.45397536
138GnRH signaling pathway_Homo sapiens_hsa049120.44705915
139Cardiac muscle contraction_Homo sapiens_hsa042600.44271129
140Measles_Homo sapiens_hsa051620.44133156
141Long-term depression_Homo sapiens_hsa047300.43576625
142Shigellosis_Homo sapiens_hsa051310.43327566
143Carbon metabolism_Homo sapiens_hsa012000.43135864
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43078874
145Huntingtons disease_Homo sapiens_hsa050160.42638175
146Pancreatic cancer_Homo sapiens_hsa052120.42094576
147Hepatitis B_Homo sapiens_hsa051610.41949388
148Glutamatergic synapse_Homo sapiens_hsa047240.41920286
149Regulation of autophagy_Homo sapiens_hsa041400.40605491
150Lysine degradation_Homo sapiens_hsa003100.39327044
151Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39075366
152One carbon pool by folate_Homo sapiens_hsa006700.39011092
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38610358
154Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38407188
155Melanogenesis_Homo sapiens_hsa049160.37445582
156Arachidonic acid metabolism_Homo sapiens_hsa005900.37360553
157Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35615997
158Wnt signaling pathway_Homo sapiens_hsa043100.34939178
159Oocyte meiosis_Homo sapiens_hsa041140.33814080
160Mismatch repair_Homo sapiens_hsa034300.31465481
161Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30978001
162Basal cell carcinoma_Homo sapiens_hsa052170.30786738
163Fructose and mannose metabolism_Homo sapiens_hsa000510.30253166

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