SLC7A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.36921058
2regulation of guanylate cyclase activity (GO:0031282)7.91477987
3drug transmembrane transport (GO:0006855)7.87243435
4angiotensin maturation (GO:0002003)7.76475155
5epoxygenase P450 pathway (GO:0019373)7.45959460
6drug catabolic process (GO:0042737)7.32482223
7drug transport (GO:0015893)7.26565260
8intestinal cholesterol absorption (GO:0030299)7.26049507
9urate metabolic process (GO:0046415)7.09797344
10fat-soluble vitamin biosynthetic process (GO:0042362)6.75895195
11positive regulation of guanylate cyclase activity (GO:0031284)6.30147552
12lysine metabolic process (GO:0006553)6.16622929
13lysine catabolic process (GO:0006554)6.16622929
14aminoglycoside antibiotic metabolic process (GO:0030647)5.99022616
15organic cation transport (GO:0015695)5.72920544
16regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.50392877
17phosphate ion transport (GO:0006817)5.50324119
18exogenous drug catabolic process (GO:0042738)5.36268537
19regulation of systemic arterial blood pressure by hormone (GO:0001990)5.31647037
20regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.31647037
21endocrine process (GO:0050886)5.31647037
22flavonoid metabolic process (GO:0009812)5.16097058
23renal absorption (GO:0070293)5.14045375
24cysteine metabolic process (GO:0006534)4.96975997
25adhesion of symbiont to host cell (GO:0044650)4.92654558
26virion attachment to host cell (GO:0019062)4.92654558
27* modified amino acid transport (GO:0072337)4.88105131
28cellular glucuronidation (GO:0052695)4.84218274
29peptide catabolic process (GO:0043171)4.82197157
30uronic acid metabolic process (GO:0006063)4.81707709
31glucuronate metabolic process (GO:0019585)4.81707709
32regulation of cGMP biosynthetic process (GO:0030826)4.81088365
33regulation of systemic arterial blood pressure (GO:0003073)4.80521979
34excretion (GO:0007588)4.79751445
35very-low-density lipoprotein particle assembly (GO:0034379)4.78181570
36vitamin D metabolic process (GO:0042359)4.76909018
37nonribosomal peptide biosynthetic process (GO:0019184)4.73138056
38phosphate ion transmembrane transport (GO:0035435)4.72333135
39quaternary ammonium group transport (GO:0015697)4.72146275
40bile acid and bile salt transport (GO:0015721)4.70971728
41actin filament depolymerization (GO:0030042)4.68291950
42homocysteine metabolic process (GO:0050667)4.63661394
43peptide hormone processing (GO:0016486)4.59257448
44regulation of cellular extravasation (GO:0002691)4.56815629
45glutathione biosynthetic process (GO:0006750)4.48505914
46alkaloid metabolic process (GO:0009820)4.45153057
47regulation of bile acid biosynthetic process (GO:0070857)4.41186200
48oligosaccharide catabolic process (GO:0009313)4.37779853
49fructose metabolic process (GO:0006000)4.35317310
50polyol transport (GO:0015791)4.33451999
51receptor guanylyl cyclase signaling pathway (GO:0007168)4.32480944
52vitamin A metabolic process (GO:0006776)4.29004843
53trivalent inorganic anion homeostasis (GO:0072506)4.21847624
54phosphate ion homeostasis (GO:0055062)4.21847624
55glyoxylate metabolic process (GO:0046487)4.20462723
56NADH metabolic process (GO:0006734)4.18359851
57response to phenylpropanoid (GO:0080184)4.15910262
58urea cycle (GO:0000050)4.09644143
59drinking behavior (GO:0042756)4.09628305
60urea metabolic process (GO:0019627)4.07436615
61regulation of cGMP metabolic process (GO:0030823)4.06053200
62arginine metabolic process (GO:0006525)4.04601780
63response to mercury ion (GO:0046689)4.04410567
64transepithelial transport (GO:0070633)4.00112744
65vitamin transport (GO:0051180)3.99893161
66sulfate transmembrane transport (GO:1902358)3.99541198
67aspartate family amino acid catabolic process (GO:0009068)3.97990207
68adhesion of symbiont to host (GO:0044406)3.97893118
69vitamin biosynthetic process (GO:0009110)3.93383919
70vitamin transmembrane transport (GO:0035461)3.92817069
71tricarboxylic acid metabolic process (GO:0072350)3.92698802
72purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.87643501
733-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.87643501
74renal system process involved in regulation of blood volume (GO:0001977)3.85541444
75carnitine transport (GO:0015879)3.85095362
76amino-acid betaine transport (GO:0015838)3.85095362
77cellular response to nitric oxide (GO:0071732)3.81748345
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.78535103
79short-chain fatty acid metabolic process (GO:0046459)3.78378816
80nitrogen cycle metabolic process (GO:0071941)3.76006562
81bile acid metabolic process (GO:0008206)3.74700131
82drug metabolic process (GO:0017144)3.72127116
83glucose 6-phosphate metabolic process (GO:0051156)3.71650831
84positive regulation of glycoprotein biosynthetic process (GO:0010560)3.71422891
85lipoprotein metabolic process (GO:0042157)3.69418693
86protein-lipid complex assembly (GO:0065005)3.68981416
87peptide biosynthetic process (GO:0043043)3.68854007
88diacylglycerol metabolic process (GO:0046339)3.65298409
89positive regulation of cGMP biosynthetic process (GO:0030828)3.65253676
90toxin transport (GO:1901998)3.60514970
91regulation of cholesterol homeostasis (GO:2000188)3.58074549
92cytidine deamination (GO:0009972)3.56319316
93cytidine metabolic process (GO:0046087)3.56319316
94cytidine catabolic process (GO:0006216)3.56319316
95digestive system process (GO:0022600)3.54786665
96* sulfur compound transport (GO:0072348)3.53806093
97proline metabolic process (GO:0006560)3.53479227
98glycolipid catabolic process (GO:0019377)3.52144170
99lipoprotein transport (GO:0042953)3.51630151
100glycerol metabolic process (GO:0006071)3.49775902
101alditol metabolic process (GO:0019400)3.49543841
102hormone catabolic process (GO:0042447)3.47111590
103amino-acid betaine metabolic process (GO:0006577)3.46885612
104hydrogen peroxide catabolic process (GO:0042744)3.45339267
105cellular carbohydrate catabolic process (GO:0044275)3.45232070
106regulation of vitamin metabolic process (GO:0030656)3.44848330
107bicarbonate transport (GO:0015701)3.43904906
108quinone biosynthetic process (GO:1901663)3.43889120
109glycosphingolipid catabolic process (GO:0046479)3.43271742
110glutathione derivative biosynthetic process (GO:1901687)3.42470110
111glutathione derivative metabolic process (GO:1901685)3.42470110
112maintenance of gastrointestinal epithelium (GO:0030277)3.41568578
113positive regulation of triglyceride lipase activity (GO:0061365)3.40091229
114positive regulation of lipoprotein lipase activity (GO:0051006)3.40091229
115high-density lipoprotein particle remodeling (GO:0034375)3.37369995
116antibacterial humoral response (GO:0019731)3.37366048
117fatty acid beta-oxidation (GO:0006635)3.33576413
118negative regulation of cholesterol transport (GO:0032375)3.32582809
119negative regulation of sterol transport (GO:0032372)3.32582809
120response to nitric oxide (GO:0071731)3.31470979
121carnitine metabolic process (GO:0009437)3.31144646
122omega-hydroxylase P450 pathway (GO:0097267)3.31074950
123cobalamin metabolic process (GO:0009235)3.30613695
124triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30038158
125glutathione metabolic process (GO:0006749)3.28968489
126cellular modified amino acid catabolic process (GO:0042219)3.27751447
127sulfate transport (GO:0008272)3.27595792
128pyrimidine ribonucleoside catabolic process (GO:0046133)3.25561374
129sphingomyelin metabolic process (GO:0006684)3.25363353
130heme transport (GO:0015886)3.24921078
131antimicrobial humoral response (GO:0019730)3.24383398
132L-ascorbic acid metabolic process (GO:0019852)3.23889558
133regulation of triglyceride catabolic process (GO:0010896)3.22455917
134cGMP biosynthetic process (GO:0006182)3.20983253
135glutamine family amino acid biosynthetic process (GO:0009084)3.18389974
136positive regulation of pseudopodium assembly (GO:0031274)3.18234304
137response to hepatocyte growth factor (GO:0035728)3.18217861
138cellular response to hepatocyte growth factor stimulus (GO:0035729)3.18217861
139positive regulation of glycoprotein metabolic process (GO:1903020)3.17691398
140negative regulation of digestive system process (GO:0060457)3.17098527
141beta-amyloid metabolic process (GO:0050435)3.16313335
142digestion (GO:0007586)3.16235816
143protein-lipid complex remodeling (GO:0034368)3.15784963
144macromolecular complex remodeling (GO:0034367)3.15784963
145plasma lipoprotein particle remodeling (GO:0034369)3.15784963
146response to hydroperoxide (GO:0033194)3.14861663
147sterol homeostasis (GO:0055092)3.14547028
148glycosylceramide metabolic process (GO:0006677)3.12720946
149regulation of cholesterol esterification (GO:0010872)3.12059753
150mRNA modification (GO:0016556)3.10682805
151fat-soluble vitamin metabolic process (GO:0006775)3.10249318
1522-oxoglutarate metabolic process (GO:0006103)3.10193243
153positive regulation of cGMP metabolic process (GO:0030825)3.09974545
154positive regulation of lipid catabolic process (GO:0050996)3.09743177
155metanephric tubule development (GO:0072170)3.09065945
156metanephric nephron tubule development (GO:0072234)3.09065945
157plasma lipoprotein particle assembly (GO:0034377)3.08539102
158phospholipid efflux (GO:0033700)3.07252263
159calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.07094960
160cholesterol homeostasis (GO:0042632)3.06932889
161sodium ion transport (GO:0006814)3.06051770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.39068620
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.90657636
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.61590962
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.89704948
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.79591664
6* HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.41274485
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.37171789
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.32933559
9SOX2_27498859_Chip-Seq_STOMACH_Mouse3.04694982
10GATA4_25053715_ChIP-Seq_YYC3_Human2.80836589
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.80645392
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.75722013
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.72903648
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.43766570
15GATA6_25053715_ChIP-Seq_YYC3_Human2.41830175
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.36099565
17GATA1_22025678_ChIP-Seq_K562_Human2.35849784
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.34480048
19SOX2_20726797_ChIP-Seq_SW620_Human2.10561602
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.97599408
21AR_21909140_ChIP-Seq_LNCAP_Human1.97120440
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90955336
23* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.89530155
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87907333
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87091465
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80283052
27CLOCK_20551151_ChIP-Seq_293T_Human1.79780801
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77937403
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76421485
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67832295
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.66601964
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.64208165
33VDR_22108803_ChIP-Seq_LS180_Human1.55786701
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.53697662
35RACK7_27058665_Chip-Seq_MCF-7_Human1.53648080
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48503679
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45546990
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44186349
39BCAT_22108803_ChIP-Seq_LS180_Human1.43066280
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43028855
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40101095
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37565061
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.34857528
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34661279
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34484425
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33982690
47* NANOG_20526341_ChIP-Seq_ESCs_Human1.33977603
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33898375
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33314766
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32206335
51FOXA1_21572438_ChIP-Seq_LNCaP_Human1.31590439
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.28864982
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28112158
54LXR_22292898_ChIP-Seq_THP-1_Human1.27932605
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27374373
56FOXA1_25552417_ChIP-Seq_VCAP_Human1.27240049
57GATA2_19941826_ChIP-Seq_K562_Human1.26775323
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26770768
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24929445
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24515209
61EGR1_19032775_ChIP-ChIP_M12_Human1.23523002
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23085557
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20289221
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.19675604
65NCOR_22424771_ChIP-Seq_293T_Human1.19448104
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18689781
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18577726
68CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.17623598
69KLF5_25053715_ChIP-Seq_YYC3_Human1.17367616
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17151452
71ATF3_27146783_Chip-Seq_COLON_Human1.16651912
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16470131
73GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.15216064
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14483327
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.14483327
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13152958
77* AR_20517297_ChIP-Seq_VCAP_Human1.12932710
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11445799
79TCF4_22108803_ChIP-Seq_LS180_Human1.11191543
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10127758
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09964016
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09916355
83SMAD3_21741376_ChIP-Seq_HESCs_Human1.09081311
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08705752
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07952983
86CEBPB_22108803_ChIP-Seq_LS180_Human1.07063311
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.05232291
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05113230
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04244958
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.02895041
91KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01447675
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01444467
93* MYC_19829295_ChIP-Seq_ESCs_Human1.01164898
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00316921
95CREB1_26743006_Chip-Seq_LNCaP_Human0.99146902
96BCL6_27268052_Chip-Seq_Bcells_Human0.98399321
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97896113
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97869891
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97715927
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96825775
101P53_21459846_ChIP-Seq_SAOS-2_Human0.92004691
102HNFA_21074721_ChIP-Seq_CACO-2_Human0.90574163
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89589106
104VDR_24787735_ChIP-Seq_THP-1_Human0.88999670
105CDX2_22108803_ChIP-Seq_LS180_Human0.88839662
106* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87945590
107STAT1_20625510_ChIP-Seq_HELA_Human0.86563808
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86552920
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85444633
110SA1_27219007_Chip-Seq_Bcells_Human0.85146893
111ZNF274_21170338_ChIP-Seq_K562_Hela0.84358311
112CBP_21632823_ChIP-Seq_H3396_Human0.83614789
113SOX2_19829295_ChIP-Seq_ESCs_Human0.83582585
114NANOG_19829295_ChIP-Seq_ESCs_Human0.83582585
115PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83435907
116DROSHA_22980978_ChIP-Seq_HELA_Human0.83262399
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83171998
118NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82945835
119ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82558002
120GATA3_21878914_ChIP-Seq_MCF-7_Human0.82412603
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82179016
122ETV1_20927104_ChIP-Seq_GIST48_Human0.82089142
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81904410
124FOXH1_21741376_ChIP-Seq_ESCs_Human0.81286580
125P300_19829295_ChIP-Seq_ESCs_Human0.80965198
126RXR_22108803_ChIP-Seq_LS180_Human0.80364737
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.80362362
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80295132
129NFYA_21822215_ChIP-Seq_K562_Human0.79981632
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79797663
131CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79612829
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79039783
133P68_20966046_ChIP-Seq_HELA_Human0.78874389
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78752041
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78720168
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78670542
137TP63_23658742_ChIP-Seq_EP156T_Human0.78540567
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78266596
139GATA1_19941826_ChIP-Seq_K562_Human0.78023149
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77981416
141TP63_22573176_ChIP-Seq_HFKS_Human0.76826642
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76818180
143GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76610560
144JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76565636
145PHF8_20622853_ChIP-Seq_HELA_Human0.76458009
146MYC_19915707_ChIP-ChIP_AK7_Human0.76443134
147RBPJ_21746931_ChIP-Seq_IB4_Human0.76138477
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75984116
149POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75233366
150BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74890560
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.74821776
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.74479596
153CTCF_27219007_Chip-Seq_Bcells_Human0.73882264
154TAF2_19829295_ChIP-Seq_ESCs_Human0.73797496
155BCOR_27268052_Chip-Seq_Bcells_Human0.73664686
156STAT1_17558387_ChIP-Seq_HELA_Human0.73562990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005360_urolithiasis7.60128308
2MP0004043_abnormal_pH_regulation5.00231934
3MP0002139_abnormal_hepatobiliary_system4.79807743
4MP0004019_abnormal_vitamin_homeostasis4.50632881
5MP0001666_abnormal_nutrient_absorption4.48679376
6MP0003252_abnormal_bile_duct3.47484682
7* MP0005332_abnormal_amino_acid3.41221145
8MP0008875_abnormal_xenobiotic_pharmacok3.27347066
9MP0005085_abnormal_gallbladder_physiolo3.26709697
10MP0003878_abnormal_ear_physiology3.25895164
11MP0005377_hearing/vestibular/ear_phenot3.25895164
12MP0004264_abnormal_extraembryonic_tissu3.24249889
13MP0009379_abnormal_foot_pigmentation3.21841461
14* MP0009643_abnormal_urine_homeostasis3.03305341
15MP0001765_abnormal_ion_homeostasis2.79366230
16MP0010234_abnormal_vibrissa_follicle2.70344979
17MP0009840_abnormal_foam_cell2.69796852
18MP0005365_abnormal_bile_salt2.60396830
19MP0003183_abnormal_peptide_metabolism2.59569527
20MP0005636_abnormal_mineral_homeostasis2.33249693
21MP0002138_abnormal_hepatobiliary_system2.19821933
22MP0005084_abnormal_gallbladder_morpholo2.16680400
23MP0004147_increased_porphyrin_level2.13822426
24* MP0002136_abnormal_kidney_physiology2.13585785
25MP0003195_calcinosis2.13104002
26MP0001756_abnormal_urination2.12108858
27MP0010329_abnormal_lipoprotein_level2.08071606
28MP0003868_abnormal_feces_composition2.07171423
29MP0000462_abnormal_digestive_system1.68146255
30MP0005409_darkened_coat_color1.67869849
31MP0002876_abnormal_thyroid_physiology1.66837918
32MP0001501_abnormal_sleep_pattern1.64608151
33MP0003300_gastrointestinal_ulcer1.62642849
34MP0003866_abnormal_defecation1.60662408
35MP0003191_abnormal_cellular_cholesterol1.50006531
36MP0005451_abnormal_body_composition1.49125546
37MP0001188_hyperpigmentation1.47426193
38MP0003806_abnormal_nucleotide_metabolis1.44328230
39MP0004270_analgesia1.31492663
40MP0002089_abnormal_postnatal_growth/wei1.31068490
41MP0001958_emphysema1.30895208
42MP0001663_abnormal_digestive_system1.23000415
43MP0002796_impaired_skin_barrier1.22019490
44MP0005584_abnormal_enzyme/coenzyme_acti1.21895443
45MP0000537_abnormal_urethra_morphology1.20767450
46MP0003283_abnormal_digestive_organ1.20296579
47MP0005381_digestive/alimentary_phenotyp1.16019105
48MP0005319_abnormal_enzyme/_coenzyme1.15574033
49MP0001664_abnormal_digestion1.15441629
50MP0002118_abnormal_lipid_homeostasis1.13234130
51MP0008961_abnormal_basal_metabolism1.10768298
52MP0004885_abnormal_endolymph1.10407389
53* MP0000538_abnormal_urinary_bladder1.09027587
54MP0005058_abnormal_lysosome_morphology1.07991597
55MP0000477_abnormal_intestine_morphology0.99556176
56MP0003705_abnormal_hypodermis_morpholog0.98509764
57MP0004782_abnormal_surfactant_physiolog0.97811527
58MP0001764_abnormal_homeostasis0.96038236
59MP0010155_abnormal_intestine_physiology0.95566620
60MP0000230_abnormal_systemic_arterial0.95173986
61MP0000609_abnormal_liver_physiology0.94800392
62MP0002822_catalepsy0.90570934
63MP0005501_abnormal_skin_physiology0.85485042
64MP0005174_abnormal_tail_pigmentation0.83982323
65MP0001873_stomach_inflammation0.82122830
66MP0005167_abnormal_blood-brain_barrier0.80516715
67MP0009785_altered_susceptibility_to0.80091575
68MP0003638_abnormal_response/metabolism_0.79807338
69* MP0001845_abnormal_inflammatory_respons0.79592440
70MP0005666_abnormal_adipose_tissue0.78834520
71MP0009115_abnormal_fat_cell0.77870817
72MP0000490_abnormal_crypts_of0.76575131
73MP0005448_abnormal_energy_balance0.75425589
74* MP0009642_abnormal_blood_homeostasis0.74867495
75MP0003315_abnormal_perineum_morphology0.71110022
76MP0003186_abnormal_redox_activity0.70452108
77MP0002098_abnormal_vibrissa_morphology0.70283943
78MP0006054_spinal_hemorrhage0.70193618
79MP0003724_increased_susceptibility_to0.69241062
80MP0000427_abnormal_hair_cycle0.67280601
81MP0003879_abnormal_hair_cell0.66865894
82* MP0002135_abnormal_kidney_morphology0.65763614
83MP0004858_abnormal_nervous_system0.64769124
84MP0000015_abnormal_ear_pigmentation0.63751337
85MP0010352_gastrointestinal_tract_polyps0.63711264
86MP0006036_abnormal_mitochondrial_physio0.63263083
87MP0005645_abnormal_hypothalamus_physiol0.60545007
88MP0005535_abnormal_body_temperature0.60140081
89MP0002896_abnormal_bone_mineralization0.59928747
90MP0000678_abnormal_parathyroid_gland0.59665610
91MP0005671_abnormal_response_to0.57911616
92MP0002254_reproductive_system_inflammat0.57545505
93MP0001849_ear_inflammation0.57092345
94MP0005334_abnormal_fat_pad0.56726170
95MP0000249_abnormal_blood_vessel0.56687623
96MP0003718_maternal_effect0.56179758
97MP0008872_abnormal_physiological_respon0.54480156
98MP0005266_abnormal_metabolism0.53975795
99MP0001986_abnormal_taste_sensitivity0.52181490
100MP0002069_abnormal_eating/drinking_beha0.51682103
101MP0000604_amyloidosis0.51020980
102MP0009764_decreased_sensitivity_to0.50348139
103MP0005166_decreased_susceptibility_to0.49770847
104MP0001835_abnormal_antigen_presentation0.48895310
105MP0008775_abnormal_heart_ventricle0.48836600
106MP0009780_abnormal_chondrocyte_physiolo0.47950532
107MP0000465_gastrointestinal_hemorrhage0.47377166
108MP0000598_abnormal_liver_morphology0.47186127
109MP0005025_abnormal_response_to0.47140217
110MP0005395_other_phenotype0.47109228
111MP0005387_immune_system_phenotype0.46169468
112MP0001790_abnormal_immune_system0.46169468
113MP0004484_altered_response_of0.46159093
114MP0008469_abnormal_protein_level0.44864616
115MP0000467_abnormal_esophagus_morphology0.44796511
116MP0002078_abnormal_glucose_homeostasis0.44190940
117MP0003953_abnormal_hormone_level0.43789937
118MP0005376_homeostasis/metabolism_phenot0.43579074
119MP0002166_altered_tumor_susceptibility0.43330194
120MP0005367_renal/urinary_system_phenotyp0.43252204
121MP0000516_abnormal_urinary_system0.43252204
122MP0006082_CNS_inflammation0.43188688
123MP0002148_abnormal_hypersensitivity_rea0.42304900
124MP0005165_increased_susceptibility_to0.40897463
125MP0001216_abnormal_epidermal_layer0.40131344
126MP0001485_abnormal_pinna_reflex0.39974572
127MP0005551_abnormal_eye_electrophysiolog0.39536781
128MP0002168_other_aberrant_phenotype0.39160084
129MP0005310_abnormal_salivary_gland0.38944171
130MP0005670_abnormal_white_adipose0.38781243
131MP0009697_abnormal_copulation0.38712789
132MP0005408_hypopigmentation0.38646207
133MP0005410_abnormal_fertilization0.38456897
134MP0009053_abnormal_anal_canal0.37988181
135MP0001191_abnormal_skin_condition0.37356988
136MP0002971_abnormal_brown_adipose0.36146081

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.32009143
2Metabolic alkalosis (HP:0200114)6.29995932
3Hyperactive renin-angiotensin system (HP:0000841)6.18328003
4Hypokalemic alkalosis (HP:0001949)5.78163656
5Abnormality of chloride homeostasis (HP:0011422)5.62406458
6Hyperglycinuria (HP:0003108)5.47556355
7* Abnormality of glutamine family amino acid metabolism (HP:0010902)5.44712725
8Hypomagnesemia (HP:0002917)5.44415697
9Gout (HP:0001997)5.35721086
10Abnormal urine output (HP:0012590)5.28763432
11Polyuria (HP:0000103)5.09626441
12Abnormality of magnesium homeostasis (HP:0004921)5.07780308
13Hydroxyprolinuria (HP:0003080)5.06521606
14Abnormality of proline metabolism (HP:0010907)5.06521606
15Proximal tubulopathy (HP:0000114)5.00187011
16Abnormality of renal excretion (HP:0011036)4.99278557
17Abnormality of purine metabolism (HP:0004352)4.41052505
18Hyperuricemia (HP:0002149)4.27981220
19Increased purine levels (HP:0004368)4.27981220
20Glycosuria (HP:0003076)4.22985766
21Abnormality of urine glucose concentration (HP:0011016)4.22985766
22Abnormality of glycine metabolism (HP:0010895)4.22004930
23Abnormality of serine family amino acid metabolism (HP:0010894)4.22004930
24Malnutrition (HP:0004395)4.16131670
25Ileus (HP:0002595)4.12563550
26Abnormality of renin-angiotensin system (HP:0000847)4.04424951
27Alkalosis (HP:0001948)4.01180932
28Abnormal drinking behavior (HP:0030082)3.96739316
29Polydipsia (HP:0001959)3.96739316
30Hyperaldosteronism (HP:0000859)3.94861577
31Tetany (HP:0001281)3.88534579
32Renal salt wasting (HP:0000127)3.69776146
33Decreased circulating renin level (HP:0003351)3.68384521
34Systemic lupus erythematosus (HP:0002725)3.67641707
35Hypercalciuria (HP:0002150)3.66964265
36Congenital sensorineural hearing impairment (HP:0008527)3.59099862
37Hyperphosphaturia (HP:0003109)3.48039261
38Widely patent fontanelles and sutures (HP:0004492)3.44057385
39Generalized aminoaciduria (HP:0002909)3.39108690
40Abnormality of nucleobase metabolism (HP:0010932)3.34764786
41Ketoacidosis (HP:0001993)3.27474216
42Autoimmune thrombocytopenia (HP:0001973)3.27401596
43Abnormal urine phosphate concentration (HP:0012599)3.22098569
44Dehydration (HP:0001944)3.15223682
45Confusion (HP:0001289)3.14902627
46Hypokalemia (HP:0002900)3.09716799
47Steatorrhea (HP:0002570)3.00642881
48Posterior subcapsular cataract (HP:0007787)3.00029441
49Delayed epiphyseal ossification (HP:0002663)2.97123478
50* Nephrolithiasis (HP:0000787)2.96931710
51Renal tubular acidosis (HP:0001947)2.96817045
52Hypolipoproteinemia (HP:0010981)2.94370992
53Abnormality of the vitamin B12 metabolism (HP:0004341)2.89438217
54Facial shape deformation (HP:0011334)2.80823693
55Potter facies (HP:0002009)2.80823693
56Hypophosphatemia (HP:0002148)2.72090339
57Abnormality of vitamin B metabolism (HP:0004340)2.68555867
58Acanthocytosis (HP:0001927)2.65720155
59Epidermoid cyst (HP:0200040)2.65588951
60Hypobetalipoproteinemia (HP:0003563)2.64579806
61Abnormality of fatty-acid metabolism (HP:0004359)2.63995569
62Ketosis (HP:0001946)2.61230449
63Metabolic acidosis (HP:0001942)2.59180266
64Hyperammonemia (HP:0001987)2.54049488
65Abnormality of potassium homeostasis (HP:0011042)2.51380363
66Conjugated hyperbilirubinemia (HP:0002908)2.46342900
67Thin bony cortex (HP:0002753)2.44059644
68Vascular calcification (HP:0004934)2.35275401
69Pancreatitis (HP:0001733)2.33456171
70Rickets (HP:0002748)2.32135208
71Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30717672
72Fat malabsorption (HP:0002630)2.25286961
73Metaphyseal cupping (HP:0003021)2.24870589
74Nephrocalcinosis (HP:0000121)2.24504304
75Nausea (HP:0002018)2.23647424
76Focal segmental glomerulosclerosis (HP:0000097)2.23591775
77Xanthomatosis (HP:0000991)2.22005830
78Megaloblastic anemia (HP:0001889)2.21955273
79Abnormal tarsal ossification (HP:0008369)2.20066096
80Hypoalbuminemia (HP:0003073)2.19370029
81Abnormal albumin level (HP:0012116)2.19370029
82Chronic diarrhea (HP:0002028)2.18125565
83Cerebral palsy (HP:0100021)2.18046606
84Abnormality of pyrimidine metabolism (HP:0004353)2.14863284
85Wide cranial sutures (HP:0010537)2.13909642
86Vomiting (HP:0002013)2.13628382
87Cupped ribs (HP:0000887)2.11172608
88Poikilocytosis (HP:0004447)2.09023334
89Abnormality of small intestinal villus morphology (HP:0011472)2.08886880
90Villous atrophy (HP:0011473)2.08886880
91Irritability (HP:0000737)2.08711473
92Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08641628
93Dicarboxylic aciduria (HP:0003215)2.08641628
94Abnormality of vitamin metabolism (HP:0100508)2.08155067
95Cardiovascular calcification (HP:0011915)2.07675151
96Hyperglycinemia (HP:0002154)2.06692740
97Vacuolated lymphocytes (HP:0001922)2.06581653
98Glomerulonephritis (HP:0000099)2.05651829
99Abdominal distention (HP:0003270)2.05281907
100Abnormality of sodium homeostasis (HP:0010931)2.00894508
101Hyponatremia (HP:0002902)1.99622435
102Chorioretinal atrophy (HP:0000533)1.99522470
103Hyperventilation (HP:0002883)1.95566667
104Delayed CNS myelination (HP:0002188)1.95469708
105Protuberant abdomen (HP:0001538)1.95397611
106Adrenal overactivity (HP:0002717)1.93926161
107Abnormal glucose tolerance (HP:0001952)1.93248570
108Hyperphosphatemia (HP:0002905)1.91920601
109Hyperparathyroidism (HP:0000843)1.91885114
110Right ventricular cardiomyopathy (HP:0011663)1.91266306
111Renal tubular dysfunction (HP:0000124)1.91036882
112Hypophosphatemic rickets (HP:0004912)1.90185123
113Complement deficiency (HP:0004431)1.87727323
114Abnormal enzyme/coenzyme activity (HP:0012379)1.87452664
115Hypotension (HP:0002615)1.87356716
116Lethargy (HP:0001254)1.87012437
117Subcapsular cataract (HP:0000523)1.86818797
118Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86579686
119* Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86413661
120Autoimmune hemolytic anemia (HP:0001890)1.85267759
121Hemorrhage of the eye (HP:0011885)1.85191293
122Abnormality of alkaline phosphatase activity (HP:0004379)1.82803821
123Methylmalonic aciduria (HP:0012120)1.82156282
124Abnormality of the costochondral junction (HP:0000919)1.81241254
125Nephritis (HP:0000123)1.79145652
126Abnormality of carpal bone ossification (HP:0006257)1.77744940
127Pigmentary retinal degeneration (HP:0001146)1.77432561
128Metaphyseal irregularity (HP:0003025)1.74910061
129Hypothermia (HP:0002045)1.73248969
130Chondrocalcinosis (HP:0000934)1.72829675
131Enlarged epiphyses (HP:0010580)1.72561803
132Late onset (HP:0003584)1.72499262
133Intrahepatic cholestasis (HP:0001406)1.71167014
134Glomerulosclerosis (HP:0000096)1.69281792
135Abnormality of complement system (HP:0005339)1.64149223
136Abnormal biliary tract morphology (HP:0012440)1.63460998
137Hypocalcemia (HP:0002901)1.63157557
138Patchy hypopigmentation of hair (HP:0011365)1.58642982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.36253596
2WNK46.70757803
3WNK36.19048981
4OXSR15.80484547
5MST44.23343187
6FRK4.00897999
7MST1R3.41214113
8STK393.27429756
9GRK62.63021272
10LMTK22.36599073
11NME12.09946013
12TNIK1.96223001
13STK38L1.85666502
14PRKG21.71458064
15CASK1.71217952
16RIPK11.69524236
17EPHA41.68255868
18PTK61.57726369
19NEK11.53995783
20PDK31.51418978
21PDK41.51418978
22BCKDK1.49990058
23AKT31.44532180
24ADRBK21.44094647
25ERN11.43419097
26BMPR1B1.41917733
27MAP3K21.39585080
28PDK21.37016433
29STK241.35909820
30MAP3K121.33118963
31MAP2K21.31227042
32EPHA21.30085051
33MET1.21679809
34MAP3K101.21332358
35EPHA31.17084647
36WNK11.16574045
37STK101.15900700
38MAP4K21.13868609
39EPHB21.09358617
40TXK1.05760093
41DAPK21.04828678
42LRRK21.02229481
43EPHB10.99717700
44PRKCI0.99635385
45PTK20.96715919
46IRAK10.95855497
47TLK10.95162070
48SGK4940.94511921
49SGK2230.94511921
50NLK0.92479696
51PINK10.89061610
52PAK40.87179327
53MAP3K70.86026460
54MAP3K30.85470286
55TESK20.82904186
56TAOK10.80397627
57LATS10.75727895
58TTK0.74972075
59MAPK110.73496388
60FER0.72736351
61MAP3K110.72087221
62TESK10.71688873
63STK380.71159790
64TEC0.69134931
65MAPKAPK30.69014220
66PRKAA20.65012522
67FGFR40.64862265
68SGK30.61427549
69MAP2K60.59697421
70MYLK0.59482948
71FGFR30.59433190
72BMX0.58664197
73NUAK10.58343042
74PRKAA10.57731548
75SCYL20.57490400
76PDPK10.57279365
77MAP3K80.54913049
78GSK3A0.54278629
79CAMK2D0.52217246
80DYRK1B0.52021213
81IKBKE0.50460539
82BMPR20.49510052
83KSR20.49203801
84DDR20.47251645
85CAMK2A0.46007884
86PRKACA0.45475866
87CDC42BPA0.43306405
88ERBB20.43259644
89MAPK130.42491176
90MATK0.41741457
91PAK30.40846179
92SYK0.39749724
93IGF1R0.38955587
94CSF1R0.38723162
95MAP2K10.38036060
96IRAK30.37245912
97PRKCE0.36634537
98NEK60.36381690
99PDK10.35570718
100ERBB40.35469960
101PRKG10.34611453
102PIK3CG0.33358776
103ERBB30.32918307
104SGK20.32316076
105PBK0.30662248
106RIPK40.30659189
107ADRBK10.30494568
108LYN0.30464326
109AKT20.29758227
110CAMK2B0.28232094
111LCK0.27439793
112PRKCD0.27399991
113KIT0.26341630
114IKBKB0.26070554
115PRKCA0.25879031
116CAMK2G0.25356760
117FYN0.25325436
118SGK10.24761928
119MAP3K140.24178263
120BCR0.23778150
121MAP3K10.23751298
122PRKACG0.23120523
123STK110.20565543
124PRKCZ0.20103825
125SRC0.17069105
126INSRR0.16875863
127PIM10.15758377
128CSK0.15549839
129ABL20.15240038
130CSNK1A10.13163170
131TBK10.12634398
132ROCK10.12544883
133STK30.11838050
134TIE10.10042112
135PRKCQ0.08006059
136ITK0.07206793
137JAK20.06959999
138ICK0.06461183
139MAP4K10.06373968
140GRK10.06363587
141TAOK30.05972498
142PRKD20.05761052
143PIK3CA0.05135007
144TYK20.04815083

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049773.94729699
2Fat digestion and absorption_Homo sapiens_hsa049753.57357934
3Mineral absorption_Homo sapiens_hsa049783.28248655
4Renin-angiotensin system_Homo sapiens_hsa046143.25035620
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.12466607
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.06981075
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92713404
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.41611095
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.38327459
10Bile secretion_Homo sapiens_hsa049762.34032299
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27896909
12Butanoate metabolism_Homo sapiens_hsa006502.21020290
13Sulfur metabolism_Homo sapiens_hsa009202.14262534
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11312461
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07893291
16Starch and sucrose metabolism_Homo sapiens_hsa005002.05150537
17* Protein digestion and absorption_Homo sapiens_hsa049742.01812103
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01380401
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98723162
20Tryptophan metabolism_Homo sapiens_hsa003801.98440790
21Fatty acid degradation_Homo sapiens_hsa000711.91716110
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.90206279
23Glutathione metabolism_Homo sapiens_hsa004801.84325944
24Propanoate metabolism_Homo sapiens_hsa006401.81497664
25Pyruvate metabolism_Homo sapiens_hsa006201.77523149
26Folate biosynthesis_Homo sapiens_hsa007901.72223140
27Fructose and mannose metabolism_Homo sapiens_hsa000511.64299776
28PPAR signaling pathway_Homo sapiens_hsa033201.59014976
29Peroxisome_Homo sapiens_hsa041461.58950234
30Galactose metabolism_Homo sapiens_hsa000521.57721272
31Histidine metabolism_Homo sapiens_hsa003401.57104653
32beta-Alanine metabolism_Homo sapiens_hsa004101.42524716
33Arginine and proline metabolism_Homo sapiens_hsa003301.40164969
34Carbon metabolism_Homo sapiens_hsa012001.39414920
35Glycerolipid metabolism_Homo sapiens_hsa005611.38256916
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.37207117
37Arginine biosynthesis_Homo sapiens_hsa002201.36440102
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33322067
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30511472
40Caffeine metabolism_Homo sapiens_hsa002321.29858707
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21674256
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20561374
43Fatty acid metabolism_Homo sapiens_hsa012121.14171915
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13622970
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10881476
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09962999
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.06916826
48Asthma_Homo sapiens_hsa053101.04068205
49Nitrogen metabolism_Homo sapiens_hsa009101.03136008
50Collecting duct acid secretion_Homo sapiens_hsa049661.03118332
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92532884
52Thyroid hormone synthesis_Homo sapiens_hsa049180.87650256
53Lysine degradation_Homo sapiens_hsa003100.86836537
54Biosynthesis of amino acids_Homo sapiens_hsa012300.82699735
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78860109
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78329373
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78117664
58Sphingolipid metabolism_Homo sapiens_hsa006000.74615205
59Pentose phosphate pathway_Homo sapiens_hsa000300.74103741
60Selenocompound metabolism_Homo sapiens_hsa004500.73982690
61Allograft rejection_Homo sapiens_hsa053300.73186045
62Other glycan degradation_Homo sapiens_hsa005110.72936535
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72879782
64Autoimmune thyroid disease_Homo sapiens_hsa053200.69136484
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68930258
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.68153974
67Graft-versus-host disease_Homo sapiens_hsa053320.67416140
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65530381
69ABC transporters_Homo sapiens_hsa020100.62747484
70Chemical carcinogenesis_Homo sapiens_hsa052040.60291832
71Arachidonic acid metabolism_Homo sapiens_hsa005900.56228134
72Type I diabetes mellitus_Homo sapiens_hsa049400.54657592
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54315687
74Staphylococcus aureus infection_Homo sapiens_hsa051500.53975995
75Phenylalanine metabolism_Homo sapiens_hsa003600.53864758
76Retinol metabolism_Homo sapiens_hsa008300.50865241
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.47754044
78Metabolic pathways_Homo sapiens_hsa011000.46926554
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46519725
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45830584
81Fatty acid biosynthesis_Homo sapiens_hsa000610.43586544
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42815570
83Gastric acid secretion_Homo sapiens_hsa049710.40254299
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.38128671
85Fatty acid elongation_Homo sapiens_hsa000620.33153194
86Steroid biosynthesis_Homo sapiens_hsa001000.32756157
87Renin secretion_Homo sapiens_hsa049240.32736717
88Oxidative phosphorylation_Homo sapiens_hsa001900.31997115
89Tight junction_Homo sapiens_hsa045300.31394145
90Serotonergic synapse_Homo sapiens_hsa047260.30665478
91Insulin secretion_Homo sapiens_hsa049110.29488278
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.29374038
93Cocaine addiction_Homo sapiens_hsa050300.26495062
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.23945555
95Antigen processing and presentation_Homo sapiens_hsa046120.21424764
96Ovarian steroidogenesis_Homo sapiens_hsa049130.19491163
97Complement and coagulation cascades_Homo sapiens_hsa046100.19343053
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.17756279
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16806841
100Vibrio cholerae infection_Homo sapiens_hsa051100.16700867
101Pancreatic secretion_Homo sapiens_hsa049720.16274988
102Linoleic acid metabolism_Homo sapiens_hsa005910.14675122
103Parkinsons disease_Homo sapiens_hsa050120.14634215
104Bladder cancer_Homo sapiens_hsa052190.14439188
105Choline metabolism in cancer_Homo sapiens_hsa052310.13759160
106Hepatitis C_Homo sapiens_hsa051600.13341575
107Glucagon signaling pathway_Homo sapiens_hsa049220.13020802
108Amphetamine addiction_Homo sapiens_hsa050310.12855726
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.12067753
110Hematopoietic cell lineage_Homo sapiens_hsa046400.06580840
111Inositol phosphate metabolism_Homo sapiens_hsa005620.06545750
112Lysosome_Homo sapiens_hsa041420.06257727
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05946277
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05735286
115Alzheimers disease_Homo sapiens_hsa050100.05068230
116Insulin resistance_Homo sapiens_hsa049310.04158646
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.03715085
118Tyrosine metabolism_Homo sapiens_hsa003500.02851614
119Sulfur relay system_Homo sapiens_hsa041220.01103522
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.01054020
121Type II diabetes mellitus_Homo sapiens_hsa04930-0.0719181
122Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0617516
123Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0194145
124Pertussis_Homo sapiens_hsa05133-0.0166572
125Ether lipid metabolism_Homo sapiens_hsa00565-0.0151412
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0118913

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