SLC8A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)5.59504355
2pyrimidine nucleobase catabolic process (GO:0006208)5.35111148
3muscle filament sliding (GO:0030049)5.10228521
4actin-myosin filament sliding (GO:0033275)5.10228521
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.03727909
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74536833
7synaptic vesicle maturation (GO:0016188)4.73764822
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64684558
9regulation of skeletal muscle contraction (GO:0014819)4.61490083
10vocalization behavior (GO:0071625)4.59861527
11neuron cell-cell adhesion (GO:0007158)4.48078935
12neuronal action potential propagation (GO:0019227)4.44409511
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.33043105
14locomotory exploration behavior (GO:0035641)4.24918203
15response to inactivity (GO:0014854)4.24633937
16synaptic vesicle exocytosis (GO:0016079)4.22770768
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.21760583
18protein localization to synapse (GO:0035418)4.16104709
19regulation of synaptic vesicle exocytosis (GO:2000300)4.11733799
20skeletal muscle contraction (GO:0003009)4.09484119
21nucleobase catabolic process (GO:0046113)4.07150143
22retinal cone cell development (GO:0046549)4.01691133
23actin-mediated cell contraction (GO:0070252)4.00323839
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.95213023
25regulation of rhodopsin mediated signaling pathway (GO:0022400)3.91372885
26rhodopsin mediated signaling pathway (GO:0016056)3.84953669
27regulation of glutamate receptor signaling pathway (GO:1900449)3.79347269
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.77179803
29glutamate secretion (GO:0014047)3.76314773
30regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.72128605
31myofibril assembly (GO:0030239)3.67339715
32neurotransmitter secretion (GO:0007269)3.66042015
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.62430931
34dendritic spine morphogenesis (GO:0060997)3.61005364
35regulation of relaxation of muscle (GO:1901077)3.60498184
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.59311893
37regulation of synaptic vesicle transport (GO:1902803)3.58762308
38neuron-neuron synaptic transmission (GO:0007270)3.55729611
39gamma-aminobutyric acid transport (GO:0015812)3.53874604
40transmission of nerve impulse (GO:0019226)3.52369926
41nerve growth factor signaling pathway (GO:0038180)3.50880169
42synaptic transmission, glutamatergic (GO:0035249)3.49609057
43axon ensheathment in central nervous system (GO:0032291)3.48060490
44central nervous system myelination (GO:0022010)3.48060490
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.47239779
46layer formation in cerebral cortex (GO:0021819)3.46743429
47response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.46202684
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.45422083
49membrane hyperpolarization (GO:0060081)3.42721601
50glutamate receptor signaling pathway (GO:0007215)3.37467534
51regulation of female receptivity (GO:0045924)3.36583522
52cellular potassium ion homeostasis (GO:0030007)3.34305357
53exploration behavior (GO:0035640)3.33677061
54regulation of synapse structural plasticity (GO:0051823)3.32515884
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32334466
56regulation of long-term neuronal synaptic plasticity (GO:0048169)3.31605936
57regulation of neuronal synaptic plasticity (GO:0048168)3.31359044
58central nervous system projection neuron axonogenesis (GO:0021952)3.29271639
59regulation of calcium ion transmembrane transporter activity (GO:1901019)3.28514504
60regulation of calcium ion transmembrane transport (GO:1903169)3.28514504
61striated muscle contraction (GO:0006941)3.27473390
62positive regulation of membrane potential (GO:0045838)3.26597037
63neurotransmitter transport (GO:0006836)3.25869851
64presynaptic membrane assembly (GO:0097105)3.25212992
65regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25057532
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.22345584
67regulation of postsynaptic membrane potential (GO:0060078)3.21528264
68neuron recognition (GO:0008038)3.21259273
69skeletal muscle fiber development (GO:0048741)3.20524969
70positive regulation of synapse maturation (GO:0090129)3.19811590
71epithelial cell differentiation involved in kidney development (GO:0035850)3.18550850
72cerebral cortex radially oriented cell migration (GO:0021799)3.18107015
73regulation of voltage-gated calcium channel activity (GO:1901385)3.15545716
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14969395
75adult walking behavior (GO:0007628)3.13342166
76presynaptic membrane organization (GO:0097090)3.12381888
77neurotransmitter-gated ion channel clustering (GO:0072578)3.12260150
78cerebellar Purkinje cell differentiation (GO:0021702)3.10321649
79establishment of mitochondrion localization (GO:0051654)3.09678429
80regulation of neurotransmitter secretion (GO:0046928)3.08455865
81response to pheromone (GO:0019236)3.08029175
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.07799857
83neuromuscular process controlling posture (GO:0050884)3.07451134
84long-term memory (GO:0007616)3.05810127
85positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.05164692
86cardiac myofibril assembly (GO:0055003)3.04610399
87dendrite morphogenesis (GO:0048813)3.02861084
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02759367
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01883980
90startle response (GO:0001964)3.01073250
91prepulse inhibition (GO:0060134)2.99441676
92cerebellar granule cell differentiation (GO:0021707)2.99238515
93myotube cell development (GO:0014904)2.98983294
94detection of light stimulus involved in sensory perception (GO:0050962)2.98055970
95detection of light stimulus involved in visual perception (GO:0050908)2.98055970
96actin filament-based movement (GO:0030048)2.97484306
97membrane depolarization during action potential (GO:0086010)2.96964461
98regulation of dendritic spine morphogenesis (GO:0061001)2.95492405
99response to histamine (GO:0034776)2.94667106
100axonal fasciculation (GO:0007413)2.93989252
101postsynaptic membrane organization (GO:0001941)2.92719444
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92472351
103female mating behavior (GO:0060180)2.91786435
104neuronal ion channel clustering (GO:0045161)2.90992664
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90659452
106myotube differentiation (GO:0014902)2.90558311
107regulation of neurotransmitter transport (GO:0051588)2.90183500
108striatum development (GO:0021756)2.89076265
109regulation of neurotransmitter levels (GO:0001505)2.88929662
110positive regulation of amino acid transport (GO:0051957)2.87212415
111behavioral response to cocaine (GO:0048148)2.86997964
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.86848797
113negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.86643220
114negative regulation of calcium ion transmembrane transport (GO:1903170)2.86643220
115membrane depolarization (GO:0051899)2.85837180
116regulation of vesicle fusion (GO:0031338)2.85649114
117neuromuscular synaptic transmission (GO:0007274)2.85471544
118negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85033995
119photoreceptor cell differentiation (GO:0046530)2.84425790
120eye photoreceptor cell differentiation (GO:0001754)2.84425790
121establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.84282420
122mitochondrion transport along microtubule (GO:0047497)2.84282420
123photoreceptor cell development (GO:0042461)2.83591096
124activation of protein kinase A activity (GO:0034199)2.81637483
125regulation of synaptic transmission, glutamatergic (GO:0051966)2.81489272
126negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81283409
127glycine transport (GO:0015816)2.80930093
128positive regulation of neurotransmitter transport (GO:0051590)2.78826408
129positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78760571
130synaptic vesicle endocytosis (GO:0048488)2.78465900
131regulation of membrane repolarization (GO:0060306)2.78342918
132negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.78218868
133neuromuscular process controlling balance (GO:0050885)2.77814234
134sodium ion export (GO:0071436)2.76602696
135eye photoreceptor cell development (GO:0042462)2.76368026
136auditory behavior (GO:0031223)2.76093540
137synapse organization (GO:0050808)2.76030911
138regulation of cell communication by electrical coupling (GO:0010649)2.75827135
139long-term synaptic potentiation (GO:0060291)2.74942684
140synapse assembly (GO:0007416)2.74818105
141positive regulation of synapse assembly (GO:0051965)2.74115876
142muscle fiber development (GO:0048747)2.73715636
143negative regulation of muscle contraction (GO:0045932)2.72995128
144positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72961361
145response to parathyroid hormone (GO:0071107)2.72599935
146response to auditory stimulus (GO:0010996)2.70052204
147cell migration in hindbrain (GO:0021535)2.69964478
148positive regulation of dendritic spine development (GO:0060999)2.69155782
149righting reflex (GO:0060013)2.69059258
150regulation of actin filament-based movement (GO:1903115)2.67724172
151suckling behavior (GO:0001967)2.66459400
152regulation of glutamate secretion (GO:0014048)2.64418057
153behavioral response to nicotine (GO:0035095)2.62252861
154regulation of dendrite morphogenesis (GO:0048814)2.61816520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71855180
2GBX2_23144817_ChIP-Seq_PC3_Human3.68036613
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94193005
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87499161
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84447499
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62245650
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62245650
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.54982947
9AR_21572438_ChIP-Seq_LNCaP_Human2.51265037
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46162784
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41144926
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40762594
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38881231
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36279919
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35486193
16DROSHA_22980978_ChIP-Seq_HELA_Human2.33491859
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.26736258
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.23787305
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21702639
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.20291464
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.09993567
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.06422491
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00623330
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93829731
25* REST_18959480_ChIP-ChIP_MESCs_Mouse1.82823178
26TAF15_26573619_Chip-Seq_HEK293_Human1.79158089
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74427411
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.74126611
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70038211
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67776099
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57248564
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57159203
33SMAD4_21799915_ChIP-Seq_A2780_Human1.55692001
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54629760
35* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52864889
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50983733
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47903256
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46999440
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.46564589
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46251339
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45071321
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43031165
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.42160013
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41273650
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40996766
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.39366336
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38138445
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37347661
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37229220
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36421845
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35754435
52P300_19829295_ChIP-Seq_ESCs_Human1.35602491
53ZNF274_21170338_ChIP-Seq_K562_Hela1.31288758
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30409091
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.29977297
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.28284300
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.26816582
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26370317
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24843329
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.23156520
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23089649
62* STAT3_23295773_ChIP-Seq_U87_Human1.23005706
63SCL_19346495_ChIP-Seq_HPC-7_Human1.22496074
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20559404
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19592066
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16100058
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16032401
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13507370
69AR_19668381_ChIP-Seq_PC3_Human1.12802175
70AR_25329375_ChIP-Seq_VCAP_Human1.12571882
71* ER_23166858_ChIP-Seq_MCF-7_Human1.11323462
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09061742
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.08875766
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08504961
75* RNF2_27304074_Chip-Seq_NSC_Mouse1.07452571
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07140217
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07049589
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06935509
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06533241
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05390685
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05225234
82* TCF4_23295773_ChIP-Seq_U87_Human1.04919934
83LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04433264
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04425780
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03864772
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03225590
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02884351
88* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01394169
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01311599
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.01166304
91IGF1R_20145208_ChIP-Seq_DFB_Human1.01131268
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00749817
93* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00517408
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99858015
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98531836
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97770934
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97770934
98AHR_22903824_ChIP-Seq_MCF-7_Human0.95507928
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94709751
100KDM2B_26808549_Chip-Seq_K562_Human0.94368441
101RUNX2_22187159_ChIP-Seq_PCA_Human0.94145688
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93821630
103CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93652987
104* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93172972
105* CBP_20019798_ChIP-Seq_JUKART_Human0.93172972
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92779716
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92454279
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91226023
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91226023
110FUS_26573619_Chip-Seq_HEK293_Human0.90961265
111VDR_22108803_ChIP-Seq_LS180_Human0.90899614
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90828475
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.90385166
114* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90222942
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.89654728
116KDM2B_26808549_Chip-Seq_REH_Human0.89331609
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.89293838
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.88725750
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88598526
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88384290
121CTCF_27219007_Chip-Seq_Bcells_Human0.88180238
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86610392
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.85983184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.63564998
2MP0003880_abnormal_central_pattern4.11461295
3MP0004270_analgesia3.55775928
4* MP0003635_abnormal_synaptic_transmissio3.29940040
5MP0005551_abnormal_eye_electrophysiolog3.02953228
6MP0005423_abnormal_somatic_nervous3.00818995
7MP0009046_muscle_twitch2.89014448
8MP0009745_abnormal_behavioral_response2.78940595
9MP0002064_seizures2.74046113
10MP0004145_abnormal_muscle_electrophysio2.64033324
11MP0002063_abnormal_learning/memory/cond2.60143732
12MP0001486_abnormal_startle_reflex2.53547847
13MP0002734_abnormal_mechanical_nocicepti2.44484655
14MP0002272_abnormal_nervous_system2.43130766
15MP0002822_catalepsy2.38825889
16MP0000751_myopathy2.30371301
17MP0002572_abnormal_emotion/affect_behav2.30223114
18MP0001968_abnormal_touch/_nociception2.30174404
19MP0004510_myositis2.07880332
20MP0003646_muscle_fatigue1.94057381
21MP0006072_abnormal_retinal_apoptosis1.90279026
22MP0004084_abnormal_cardiac_muscle1.89995713
23MP0002067_abnormal_sensory_capabilities1.84063565
24MP0005253_abnormal_eye_physiology1.83374745
25MP0009780_abnormal_chondrocyte_physiolo1.83032139
26MP0001501_abnormal_sleep_pattern1.78110837
27MP0001440_abnormal_grooming_behavior1.77366076
28MP0006276_abnormal_autonomic_nervous1.75946427
29MP0001529_abnormal_vocalization1.75889236
30MP0008569_lethality_at_weaning1.73444972
31MP0004142_abnormal_muscle_tone1.69336630
32MP0000778_abnormal_nervous_system1.66111558
33MP0002184_abnormal_innervation1.64046102
34MP0001984_abnormal_olfaction1.62728436
35MP0001970_abnormal_pain_threshold1.61646200
36MP0002735_abnormal_chemical_nociception1.59439314
37* MP0005386_behavior/neurological_phenoty1.57052610
38* MP0004924_abnormal_behavior1.57052610
39MP0002733_abnormal_thermal_nociception1.56873614
40MP0003011_delayed_dark_adaptation1.55856740
41MP0002909_abnormal_adrenal_gland1.54670909
42MP0002882_abnormal_neuron_morphology1.54184252
43MP0004885_abnormal_endolymph1.54028269
44MP0002736_abnormal_nociception_after1.52954987
45MP0003122_maternal_imprinting1.52327812
46* MP0002229_neurodegeneration1.50224169
47* MP0004087_abnormal_muscle_fiber1.50201266
48MP0005646_abnormal_pituitary_gland1.47788623
49MP0000920_abnormal_myelination1.45364190
50MP0002557_abnormal_social/conspecific_i1.45004589
51MP0000955_abnormal_spinal_cord1.44267079
52MP0003329_amyloid_beta_deposits1.41332460
53MP0000747_muscle_weakness1.40334786
54MP0005464_abnormal_platelet_physiology1.40152731
55MP0001502_abnormal_circadian_rhythm1.39261557
56MP0002090_abnormal_vision1.39246235
57MP0005645_abnormal_hypothalamus_physiol1.39166820
58MP0001299_abnormal_eye_distance/1.38376275
59MP0004742_abnormal_vestibular_system1.36066326
60* MP0002066_abnormal_motor_capabilities/c1.35857669
61MP0001905_abnormal_dopamine_level1.32262149
62MP0000749_muscle_degeneration1.30117808
63MP0004811_abnormal_neuron_physiology1.28224401
64MP0003950_abnormal_plasma_membrane1.24856279
65MP0003787_abnormal_imprinting1.22244106
66MP0002752_abnormal_somatic_nervous1.22040656
67MP0004233_abnormal_muscle_weight1.20623115
68MP0002638_abnormal_pupillary_reflex1.12481790
69MP0005195_abnormal_posterior_eye1.12193868
70MP0004134_abnormal_chest_morphology1.10673644
71MP0004036_abnormal_muscle_relaxation1.08894949
72MP0002269_muscular_atrophy1.07789371
73MP0003634_abnormal_glial_cell1.07252714
74MP0003633_abnormal_nervous_system1.02574638
75MP0001963_abnormal_hearing_physiology1.00432933
76MP0002972_abnormal_cardiac_muscle0.98326707
77MP0005535_abnormal_body_temperature0.98205581
78MP0000230_abnormal_systemic_arterial0.97938876
79MP0003183_abnormal_peptide_metabolism0.96563566
80MP0002152_abnormal_brain_morphology0.96328312
81MP0004484_altered_response_of0.96147315
82MP0002127_abnormal_cardiovascular_syste0.95922282
83MP0002837_dystrophic_cardiac_calcinosis0.93064169
84MP0000750_abnormal_muscle_regeneration0.92360762
85MP0003631_nervous_system_phenotype0.92023456
86MP0003690_abnormal_glial_cell0.89286025
87MP0005620_abnormal_muscle_contractility0.88600829
88MP0004858_abnormal_nervous_system0.88112348
89MP0002108_abnormal_muscle_morphology0.87482783
90MP0000631_abnormal_neuroendocrine_gland0.87234446
91MP0003879_abnormal_hair_cell0.86680831
92MP0004215_abnormal_myocardial_fiber0.84390468
93* MP0000759_abnormal_skeletal_muscle0.82908512
94MP0000733_abnormal_muscle_development0.81812433
95MP0002106_abnormal_muscle_physiology0.81601827
96MP0005369_muscle_phenotype0.80804808
97MP0001188_hyperpigmentation0.80797274
98MP0004085_abnormal_heartbeat0.80019376
99MP0001177_atelectasis0.79236949
100MP0003632_abnormal_nervous_system0.78668822
101MP0008874_decreased_physiological_sensi0.76446838
102MP0005167_abnormal_blood-brain_barrier0.76279610
103MP0003283_abnormal_digestive_organ0.75849753
104MP0002069_abnormal_eating/drinking_beha0.74498585
105MP0009250_abnormal_appendicular_skeleto0.73805173
106MP0003137_abnormal_impulse_conducting0.73406027
107MP0002332_abnormal_exercise_endurance0.70805956
108MP0010386_abnormal_urinary_bladder0.70435198
109MP0000013_abnormal_adipose_tissue0.68959855
110MP0005385_cardiovascular_system_phenoty0.68518005
111MP0001544_abnormal_cardiovascular_syste0.68518005
112MP0003045_fibrosis0.68510932
113MP0001943_abnormal_respiration0.67992428
114MP0004130_abnormal_muscle_cell0.67774147
115MP0008872_abnormal_physiological_respon0.65673343
116MP0005409_darkened_coat_color0.63904693
117MP0005394_taste/olfaction_phenotype0.63738944
118MP0005499_abnormal_olfactory_system0.63738944
119MP0010769_abnormal_survival0.62994850
120MP0001664_abnormal_digestion0.62136729
121MP0005503_abnormal_tendon_morphology0.60515953
122MP0008775_abnormal_heart_ventricle0.60271063
123MP0002971_abnormal_brown_adipose0.59811194

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.28681587
2Congenital stationary night blindness (HP:0007642)4.75895672
3Myokymia (HP:0002411)4.70600610
4Vitreoretinal degeneration (HP:0000655)4.41956614
5Dyschromatopsia (HP:0007641)4.18327042
6Central scotoma (HP:0000603)3.94814654
7Epiphyseal dysplasia (HP:0002656)3.87517847
8Focal seizures (HP:0007359)3.79027415
9Abnormality of macular pigmentation (HP:0008002)3.78138184
10Myopathic facies (HP:0002058)3.58086519
11Hyporeflexia of lower limbs (HP:0002600)3.57100691
12Progressive cerebellar ataxia (HP:0002073)3.44459958
13Epileptic encephalopathy (HP:0200134)3.42646437
14Rimmed vacuoles (HP:0003805)3.41887565
15Visual hallucinations (HP:0002367)3.41843200
16EMG: myopathic abnormalities (HP:0003458)3.41019167
17Broad-based gait (HP:0002136)3.37498258
18Calcaneovalgus deformity (HP:0001848)3.35976349
19Irregular epiphyses (HP:0010582)3.35848095
20Hypoplastic ischia (HP:0003175)3.34263864
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.29293656
22Exercise-induced myalgia (HP:0003738)3.26188452
23Bony spicule pigmentary retinopathy (HP:0007737)3.25423033
24Abnormality of the left ventricular outflow tract (HP:0011103)3.22846796
25Subaortic stenosis (HP:0001682)3.22846796
26Febrile seizures (HP:0002373)3.18200140
27Frequent falls (HP:0002359)3.14851619
28Papilledema (HP:0001085)3.13433643
29Atonic seizures (HP:0010819)3.11075327
30Scotoma (HP:0000575)3.09590772
31Bundle branch block (HP:0011710)3.07433922
32Myoglobinuria (HP:0002913)3.07206725
33Ankle clonus (HP:0011448)3.04760871
34Abnormality of skeletal muscle fiber size (HP:0012084)3.02282204
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.96704056
36Action tremor (HP:0002345)2.95343176
37Abnormality of the ischium (HP:0003174)2.95101762
38Absence seizures (HP:0002121)2.94632547
39Rhabdomyolysis (HP:0003201)2.87648429
40Deformed tarsal bones (HP:0008119)2.86923063
41Absent phalangeal crease (HP:0006109)2.82348315
42Round ear (HP:0100830)2.82139065
43Sudden death (HP:0001699)2.79449003
44Supranuclear gaze palsy (HP:0000605)2.77438721
45Small epiphyses (HP:0010585)2.75739934
46Generalized tonic-clonic seizures (HP:0002069)2.75455576
47Muscle fiber inclusion bodies (HP:0100299)2.73712280
48Muscle hypertrophy of the lower extremities (HP:0008968)2.70869325
49Abnormal rod and cone electroretinograms (HP:0008323)2.69846389
50Areflexia of lower limbs (HP:0002522)2.69708209
51Abnormality of binocular vision (HP:0011514)2.67833869
52Diplopia (HP:0000651)2.67833869
53Ulnar deviation of the wrist (HP:0003049)2.67661858
54Abnormality of the corticospinal tract (HP:0002492)2.67194907
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67099468
56Dysdiadochokinesis (HP:0002075)2.66964483
57Urinary bladder sphincter dysfunction (HP:0002839)2.66963609
58EMG: neuropathic changes (HP:0003445)2.65953414
59Gaze-evoked nystagmus (HP:0000640)2.64733896
60Dialeptic seizures (HP:0011146)2.64385390
61Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.61889831
62Spastic gait (HP:0002064)2.54541360
63Urinary urgency (HP:0000012)2.53478652
64Nemaline bodies (HP:0003798)2.53290669
65Failure to thrive in infancy (HP:0001531)2.51726800
66Prolonged bleeding time (HP:0003010)2.51501128
67Decreased central vision (HP:0007663)2.50092545
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.46739194
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46739194
70Dysmetria (HP:0001310)2.46491760
71Truncal ataxia (HP:0002078)2.46264614
72Fetal akinesia sequence (HP:0001989)2.45233204
73Neck muscle weakness (HP:0000467)2.39976556
74Lower limb amyotrophy (HP:0007210)2.37348440
75Impaired vibration sensation in the lower limbs (HP:0002166)2.37040437
76Scanning speech (HP:0002168)2.34839834
77Abnormal finger flexion creases (HP:0006143)2.34742352
78Neurofibrillary tangles (HP:0002185)2.33403183
79Long clavicles (HP:0000890)2.30336882
80Hyperkalemia (HP:0002153)2.27062779
81Hyperventilation (HP:0002883)2.26712950
82Exercise-induced muscle cramps (HP:0003710)2.25741154
83Malignant hyperthermia (HP:0002047)2.25501310
84Calf muscle hypertrophy (HP:0008981)2.23109912
85Termporal pattern (HP:0011008)2.21336985
86Insidious onset (HP:0003587)2.21336985
87Anxiety (HP:0000739)2.19714267
88Genetic anticipation (HP:0003743)2.16998560
89Mutism (HP:0002300)2.16581188
90Generalized muscle weakness (HP:0003324)2.16172000
91Abolished electroretinogram (ERG) (HP:0000550)2.15633479
92Waddling gait (HP:0002515)2.15019857
93Poor eye contact (HP:0000817)2.14658606
94Type 1 muscle fiber predominance (HP:0003803)2.12880494
95Mild short stature (HP:0003502)2.12426481
96Pheochromocytoma (HP:0002666)2.11991641
97Depression (HP:0000716)2.11955915
98Heart block (HP:0012722)2.11543787
99Difficulty running (HP:0009046)2.10403716
100Distal lower limb amyotrophy (HP:0008944)2.10268663
101Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09392069
102Intention tremor (HP:0002080)2.08077623
103Limb dystonia (HP:0002451)2.05707717
104Torticollis (HP:0000473)2.01579930
105Cupped ribs (HP:0000887)2.01435768
106Hemiparesis (HP:0001269)1.99577947
107Neonatal hypoglycemia (HP:0001998)1.98542859
108Hypothermia (HP:0002045)1.97482789
109Abnormal social behavior (HP:0012433)1.97332630
110Impaired social interactions (HP:0000735)1.97332630
111Attenuation of retinal blood vessels (HP:0007843)1.97128539
112Choroideremia (HP:0001139)1.96879301
113Abnormal eating behavior (HP:0100738)1.96202376
114Abnormality of the calf musculature (HP:0001430)1.94903811
115Myotonia (HP:0002486)1.94800859
116Postural instability (HP:0002172)1.93220686
117Lower limb muscle weakness (HP:0007340)1.92194529
118Excessive salivation (HP:0003781)1.92089685
119Drooling (HP:0002307)1.92089685
120Severe visual impairment (HP:0001141)1.88951666
121Distal arthrogryposis (HP:0005684)1.87249764
122Chorioretinal atrophy (HP:0000533)1.86913326
123Pigmentary retinal degeneration (HP:0001146)1.86440776
124Scapular winging (HP:0003691)1.86331034
125Menorrhagia (HP:0000132)1.85456721
126Pendular nystagmus (HP:0012043)1.84646679
127Increased mean platelet volume (HP:0011877)1.83301800
128Neuroendocrine neoplasm (HP:0100634)1.83051392
129Abnormal atrioventricular conduction (HP:0005150)1.82966437
130Abnormality of the pubic bones (HP:0003172)1.81494039
131Muscle fiber splitting (HP:0003555)1.80900340
132Progressive inability to walk (HP:0002505)1.80769176
133Asymmetric septal hypertrophy (HP:0001670)1.80483958
134Prolonged QT interval (HP:0001657)1.80293227
135Cerebral inclusion bodies (HP:0100314)1.79829153
136Gait imbalance (HP:0002141)1.79041190
137Delayed epiphyseal ossification (HP:0002663)1.76417512
138Relative macrocephaly (HP:0004482)1.75078747
139Increased variability in muscle fiber diameter (HP:0003557)1.74229996
140Photophobia (HP:0000613)1.73815347
141Limited hip movement (HP:0008800)1.73802110
142Slender build (HP:0001533)1.73315619
143Abnormality of the foot musculature (HP:0001436)1.71853935
144Polyphagia (HP:0002591)1.71572132
145Flat capital femoral epiphysis (HP:0003370)1.71398500
146Muscle stiffness (HP:0003552)1.71305452
147Weak cry (HP:0001612)1.69932778
148Facial diplegia (HP:0001349)1.69436889
149Abnormal platelet volume (HP:0011876)1.65614779
150Nonprogressive disorder (HP:0003680)1.63682877
151Akinesia (HP:0002304)1.63342299
152Petechiae (HP:0000967)1.63156191
153Bulbar palsy (HP:0001283)1.63136733
154Epileptiform EEG discharges (HP:0011182)1.62882738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.53235007
2MARK13.24905828
3EPHA43.05528267
4MAP3K42.92193153
5MAP3K92.77387636
6PHKG22.36325203
7PHKG12.36325203
8PAK62.22579202
9PNCK2.20242321
10MAP2K72.19656968
11MINK11.99462903
12NTRK21.98655689
13TNIK1.90730891
14MAP2K41.88475854
15CASK1.87317403
16OXSR11.85057315
17STK391.81274516
18CDK191.81215742
19NTRK11.79553393
20PIK3CG1.75820600
21NME11.64000272
22DYRK21.56988546
23TTN1.55429387
24OBSCN1.53211013
25IRAK11.51718469
26DDR21.42990161
27PINK11.42649163
28CDK51.42320227
29CAMKK11.39964325
30KSR11.38348117
31DAPK21.34277934
32KSR21.32718524
33WNK11.32151802
34PRPF4B1.26903193
35MAPK131.26701715
36UHMK11.23022000
37CCNB11.19640783
38MOS1.18849340
39SGK4941.18339985
40SGK2231.18339985
41BCR1.17016827
42MAP3K121.14605703
43PRKD31.09465976
44PKN11.05324716
45GRK11.04697495
46CAMK1G1.04309012
47PLK21.04214944
48CAMK2A0.99968037
49YES10.98953488
50SIK20.98042487
51PRKCG0.96521928
52GRK50.96096002
53LIMK10.94463129
54CAMK2B0.94222252
55CAMKK20.92787729
56NEK60.90624011
57STK110.90352556
58CDK140.87075617
59PRKCH0.86599015
60CDK180.86370080
61CSNK1G20.86311125
62MUSK0.85845175
63CDK150.85178753
64CAMK2D0.83692079
65FES0.83477470
66MAPK120.82302939
67MARK20.81671753
68DYRK1A0.81637368
69MAP4K20.81058989
70INSRR0.79387852
71STK380.79171143
72WNK40.76562703
73SGK10.74412323
74CDK11A0.73424144
75PAK30.72606993
76CAMK2G0.72300083
77TYRO30.71871696
78SGK20.71791230
79CAMK10.70171178
80SYK0.69643565
81ROCK20.68139583
82MAP3K70.65199606
83ICK0.65032352
84RET0.64974679
85SGK30.62856418
86MAP3K130.62430571
87GRK70.61003349
88CSNK1A1L0.59949878
89ERBB30.58808126
90RIPK40.57874893
91CAMK40.57465233
92CSNK1G30.57406786
93RPS6KB10.57004046
94DAPK10.56200960
95MAPK100.55824749
96TAOK10.54406699
97TNK20.54404766
98MAPK40.54089404
99ADRBK10.53982870
100RPS6KA30.53286489
101CSF1R0.52668432
102PRKCE0.52099840
103FGFR20.51958902
104ARAF0.51888911
105PRKCZ0.51325474
106PRKG10.50515665
107MAPK70.50493761
108BMX0.50284022
109ROCK10.49946292
110MAPKAPK50.49927148
111MAP2K10.48125473
112IRAK20.47407034
113MAP2K30.46874171
114FYN0.45560982
115PDPK10.45094921
116WNK30.44990662
117PDK10.44831787
118LATS20.43531833
119DYRK1B0.42319465
120TIE10.40790401
121PRKACA0.35107793
122MAP2K60.33855559
123EPHB20.33186297
124PRKCQ0.32796539
125VRK10.32185370
126PRKAA10.30094364
127RAF10.30042732
128MAPK80.29987365
129PTK2B0.29182586
130GSK3B0.29007344

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.82790275
2Nicotine addiction_Homo sapiens_hsa050333.29280187
3Synaptic vesicle cycle_Homo sapiens_hsa047212.91916178
4GABAergic synapse_Homo sapiens_hsa047272.78904304
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49548388
6Circadian entrainment_Homo sapiens_hsa047132.43939712
7* Olfactory transduction_Homo sapiens_hsa047402.42215601
8Morphine addiction_Homo sapiens_hsa050322.40021316
9Glutamatergic synapse_Homo sapiens_hsa047242.32183555
10Dopaminergic synapse_Homo sapiens_hsa047282.04130051
11Platelet activation_Homo sapiens_hsa046112.00242222
12Amphetamine addiction_Homo sapiens_hsa050311.98328773
13Long-term potentiation_Homo sapiens_hsa047201.96977163
14Salivary secretion_Homo sapiens_hsa049701.92302857
15Cholinergic synapse_Homo sapiens_hsa047251.85614182
16Serotonergic synapse_Homo sapiens_hsa047261.82079859
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76152436
18Insulin secretion_Homo sapiens_hsa049111.71954287
19Oxytocin signaling pathway_Homo sapiens_hsa049211.68813686
20Long-term depression_Homo sapiens_hsa047301.65234190
21Cocaine addiction_Homo sapiens_hsa050301.64574631
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63196847
23Gastric acid secretion_Homo sapiens_hsa049711.61882955
24Renin secretion_Homo sapiens_hsa049241.54382733
25Cardiac muscle contraction_Homo sapiens_hsa042601.53032100
26Taste transduction_Homo sapiens_hsa047421.52596064
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50367967
28* Calcium signaling pathway_Homo sapiens_hsa040201.43069694
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37049416
30Axon guidance_Homo sapiens_hsa043601.27804806
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25143242
32GnRH signaling pathway_Homo sapiens_hsa049121.22604716
33Gap junction_Homo sapiens_hsa045401.21162456
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17713542
35cAMP signaling pathway_Homo sapiens_hsa040241.15922221
36Dilated cardiomyopathy_Homo sapiens_hsa054141.14720279
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13697427
38Collecting duct acid secretion_Homo sapiens_hsa049661.13587111
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11449112
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10713620
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07146923
42* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02906857
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99367441
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.98367224
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97503687
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91623721
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90169337
48Type II diabetes mellitus_Homo sapiens_hsa049300.89808445
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89552699
50ErbB signaling pathway_Homo sapiens_hsa040120.88769321
51Vibrio cholerae infection_Homo sapiens_hsa051100.87820942
52Melanogenesis_Homo sapiens_hsa049160.84722487
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82240521
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81631888
55Estrogen signaling pathway_Homo sapiens_hsa049150.79579379
56Circadian rhythm_Homo sapiens_hsa047100.77301479
57MAPK signaling pathway_Homo sapiens_hsa040100.73966094
58Oxidative phosphorylation_Homo sapiens_hsa001900.73736546
59Pancreatic secretion_Homo sapiens_hsa049720.73590380
60Glioma_Homo sapiens_hsa052140.72711241
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.72372262
62AMPK signaling pathway_Homo sapiens_hsa041520.72154984
63Alzheimers disease_Homo sapiens_hsa050100.71958096
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70041973
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69181863
66Prolactin signaling pathway_Homo sapiens_hsa049170.66572881
67Dorso-ventral axis formation_Homo sapiens_hsa043200.65382657
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63254147
69B cell receptor signaling pathway_Homo sapiens_hsa046620.63043918
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62062704
71Thyroid hormone synthesis_Homo sapiens_hsa049180.61621621
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61329251
73Parkinsons disease_Homo sapiens_hsa050120.59639332
74Endometrial cancer_Homo sapiens_hsa052130.58894826
75Ras signaling pathway_Homo sapiens_hsa040140.56759108
76Renal cell carcinoma_Homo sapiens_hsa052110.56607620
77Insulin resistance_Homo sapiens_hsa049310.55811274
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55632294
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55575782
80Ovarian steroidogenesis_Homo sapiens_hsa049130.52960656
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52800454
82Choline metabolism in cancer_Homo sapiens_hsa052310.52712470
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.52590414
84Alcoholism_Homo sapiens_hsa050340.52454677
85Glucagon signaling pathway_Homo sapiens_hsa049220.51812158
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.51633516
87Oocyte meiosis_Homo sapiens_hsa041140.51526020
88Tight junction_Homo sapiens_hsa045300.47957955
89Wnt signaling pathway_Homo sapiens_hsa043100.46985038
90Focal adhesion_Homo sapiens_hsa045100.46378778
91ECM-receptor interaction_Homo sapiens_hsa045120.46322933
92Nitrogen metabolism_Homo sapiens_hsa009100.46004204
93beta-Alanine metabolism_Homo sapiens_hsa004100.45349302
94Chemokine signaling pathway_Homo sapiens_hsa040620.43760137
95Endocytosis_Homo sapiens_hsa041440.43601732
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43268909
97Ether lipid metabolism_Homo sapiens_hsa005650.43047598
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42502254
99Insulin signaling pathway_Homo sapiens_hsa049100.39991985
100Hedgehog signaling pathway_Homo sapiens_hsa043400.38068675
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37776406
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.37293300
103Arginine and proline metabolism_Homo sapiens_hsa003300.36852402
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36679161
105Inositol phosphate metabolism_Homo sapiens_hsa005620.36549049
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.36513886
107Non-small cell lung cancer_Homo sapiens_hsa052230.36494449
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35875641
109Bile secretion_Homo sapiens_hsa049760.34706485
110FoxO signaling pathway_Homo sapiens_hsa040680.34672418
111Rap1 signaling pathway_Homo sapiens_hsa040150.34431275
112Viral myocarditis_Homo sapiens_hsa054160.34430604
113mTOR signaling pathway_Homo sapiens_hsa041500.33700553
114Sphingolipid metabolism_Homo sapiens_hsa006000.33606278
115Asthma_Homo sapiens_hsa053100.33578754
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33229873
117Butanoate metabolism_Homo sapiens_hsa006500.32882782
118Systemic lupus erythematosus_Homo sapiens_hsa053220.32810690
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32342078
120VEGF signaling pathway_Homo sapiens_hsa043700.32327318
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31619582
122T cell receptor signaling pathway_Homo sapiens_hsa046600.31537821
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28220783

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