SLC8B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.15446561
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.99016962
3L-phenylalanine catabolic process (GO:0006559)4.87138474
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.87138474
5aromatic amino acid family catabolic process (GO:0009074)4.77471119
6indole-containing compound catabolic process (GO:0042436)4.75694082
7indolalkylamine catabolic process (GO:0046218)4.75694082
8tryptophan catabolic process (GO:0006569)4.75694082
9L-phenylalanine metabolic process (GO:0006558)4.71420939
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.71420939
11complement activation, alternative pathway (GO:0006957)4.63622241
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60638299
13negative regulation of cell killing (GO:0031342)4.60638299
14tryptophan metabolic process (GO:0006568)4.51619130
15response to peptidoglycan (GO:0032494)4.48629796
16protein carboxylation (GO:0018214)4.42050443
17peptidyl-glutamic acid carboxylation (GO:0017187)4.42050443
18neutrophil activation involved in immune response (GO:0002283)4.40767324
19kynurenine metabolic process (GO:0070189)4.39774398
20urea metabolic process (GO:0019627)4.37512271
21urea cycle (GO:0000050)4.37512271
22sulfur amino acid catabolic process (GO:0000098)4.30327002
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24557884
24high-density lipoprotein particle remodeling (GO:0034375)4.23336462
25regulation of protein activation cascade (GO:2000257)4.21453030
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20615967
27antigen processing and presentation of endogenous antigen (GO:0019883)4.15031193
28negative regulation of interleukin-12 production (GO:0032695)4.11296341
29serine family amino acid catabolic process (GO:0009071)4.07226280
30plasma lipoprotein particle clearance (GO:0034381)4.06142028
31alpha-linolenic acid metabolic process (GO:0036109)4.02656037
32regulation of complement activation (GO:0030449)3.99342458
33nitrogen cycle metabolic process (GO:0071941)3.97546561
34phospholipid efflux (GO:0033700)3.97275558
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.95878922
36bile acid biosynthetic process (GO:0006699)3.95804828
37macrophage activation involved in immune response (GO:0002281)3.93836061
38detection of other organism (GO:0098543)3.92930248
39negative regulation of erythrocyte differentiation (GO:0045647)3.91664234
40cellular extravasation (GO:0045123)3.89852021
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88287062
42regulation of gamma-delta T cell activation (GO:0046643)3.87234651
43glyoxylate metabolic process (GO:0046487)3.86767888
44reverse cholesterol transport (GO:0043691)3.86139405
45homocysteine metabolic process (GO:0050667)3.80590064
46detection of bacterium (GO:0016045)3.79972048
47negative regulation of fibrinolysis (GO:0051918)3.79359116
48regulation of triglyceride catabolic process (GO:0010896)3.77669391
49protein-lipid complex remodeling (GO:0034368)3.77425721
50macromolecular complex remodeling (GO:0034367)3.77425721
51plasma lipoprotein particle remodeling (GO:0034369)3.77425721
52regulation of cholesterol esterification (GO:0010872)3.68894638
53amino-acid betaine metabolic process (GO:0006577)3.67378683
54regulation of fibrinolysis (GO:0051917)3.65497830
55immunoglobulin mediated immune response (GO:0016064)3.62259313
56cysteine metabolic process (GO:0006534)3.61404920
57phospholipid homeostasis (GO:0055091)3.60962890
58response to muramyl dipeptide (GO:0032495)3.59812679
59regulation of gamma-delta T cell differentiation (GO:0045586)3.56514539
60disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.56424136
61killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.56424136
62bile acid metabolic process (GO:0008206)3.54905163
63plasma lipoprotein particle assembly (GO:0034377)3.54033355
64aromatic amino acid family metabolic process (GO:0009072)3.51299032
65detection of external biotic stimulus (GO:0098581)3.51282930
66cholesterol efflux (GO:0033344)3.51247980
67indolalkylamine metabolic process (GO:0006586)3.50558657
68regulation of mast cell degranulation (GO:0043304)3.50203238
69imidazole-containing compound metabolic process (GO:0052803)3.48782484
70cellular biogenic amine catabolic process (GO:0042402)3.48223996
71amine catabolic process (GO:0009310)3.48223996
72negative regulation of sterol transport (GO:0032372)3.48107570
73negative regulation of cholesterol transport (GO:0032375)3.48107570
74acylglycerol homeostasis (GO:0055090)3.44870285
75triglyceride homeostasis (GO:0070328)3.44870285
76glycine metabolic process (GO:0006544)3.42527063
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39580487
78detection of molecule of bacterial origin (GO:0032490)3.39243867
79low-density lipoprotein particle remodeling (GO:0034374)3.35179275
80regulation of myeloid leukocyte mediated immunity (GO:0002886)3.34511921
81regulation of leukocyte degranulation (GO:0043300)3.31416509
82low-density lipoprotein particle clearance (GO:0034383)3.27370902
83plasma lipoprotein particle organization (GO:0071827)3.25631167
84germinal center formation (GO:0002467)3.24101869
85positive regulation of triglyceride lipase activity (GO:0061365)3.22689255
86positive regulation of lipoprotein lipase activity (GO:0051006)3.22689255
87leukocyte aggregation (GO:0070486)3.22618327
88alpha-amino acid catabolic process (GO:1901606)3.22329486
89tyrosine metabolic process (GO:0006570)3.20821641
90fibrinolysis (GO:0042730)3.20126791
91regulation of mast cell activation involved in immune response (GO:0033006)3.18458528
92very-low-density lipoprotein particle assembly (GO:0034379)3.18407107
93positive regulation by symbiont of host defense response (GO:0052509)3.18362132
94modulation by symbiont of host defense response (GO:0052031)3.18362132
95modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18362132
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18362132
97positive regulation by organism of defense response of other organism involved in symbiotic interact3.18362132
98modulation by symbiont of host immune response (GO:0052553)3.18362132
99regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17490416
100lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16487048
101NIK/NF-kappaB signaling (GO:0038061)3.16317891
102protein-lipid complex assembly (GO:0065005)3.16073913
103complement activation (GO:0006956)3.15357054
104protein activation cascade (GO:0072376)3.15159283
105positive regulation of antigen processing and presentation (GO:0002579)3.15087030
106granulocyte activation (GO:0036230)3.14813158
107regulation of B cell receptor signaling pathway (GO:0050855)3.12971255
108pyridine nucleotide biosynthetic process (GO:0019363)3.12842134
109nicotinamide nucleotide biosynthetic process (GO:0019359)3.12842134
110NAD biosynthetic process (GO:0009435)3.12427347
111regulation of cholesterol homeostasis (GO:2000188)3.11710862
112neutrophil activation (GO:0042119)3.11325931
113positive thymic T cell selection (GO:0045059)3.09460582
114cholesterol homeostasis (GO:0042632)3.08662383
115regulation of interferon-beta biosynthetic process (GO:0045357)3.08521628
116bile acid and bile salt transport (GO:0015721)3.07994241
117serine family amino acid metabolic process (GO:0009069)3.07630065
118mannose metabolic process (GO:0006013)3.07255273
119regulation of cholesterol storage (GO:0010885)3.06595939
120positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.06474704
121respiratory burst (GO:0045730)3.06194742
122protein-lipid complex subunit organization (GO:0071825)3.05422600
123acute-phase response (GO:0006953)3.05303795
124detection of biotic stimulus (GO:0009595)3.03586257
125complement activation, classical pathway (GO:0006958)3.02967859
126myeloid cell activation involved in immune response (GO:0002275)3.02688989
127sterol homeostasis (GO:0055092)3.02549025
128macrophage activation (GO:0042116)3.02365060
129blood coagulation, intrinsic pathway (GO:0007597)2.99629149
130cellular modified amino acid catabolic process (GO:0042219)2.96850989
131amino sugar catabolic process (GO:0046348)2.96180705
132cellular glucuronidation (GO:0052695)2.95727878
133killing of cells of other organism (GO:0031640)2.95526336
134disruption of cells of other organism (GO:0044364)2.95526336
135cellular amino acid catabolic process (GO:0009063)2.94924824
136response to type I interferon (GO:0034340)2.93679664
137positive regulation of B cell differentiation (GO:0045579)2.93242652
138serine family amino acid biosynthetic process (GO:0009070)2.92816712
139type I interferon signaling pathway (GO:0060337)2.92421291
140cellular response to type I interferon (GO:0071357)2.92421291
141regulation of antigen processing and presentation (GO:0002577)2.90494310
142lipoprotein metabolic process (GO:0042157)2.90427257
143positive regulation of lipid catabolic process (GO:0050996)2.90137094
144regulation of mast cell activation (GO:0033003)2.88659449
145glycosphingolipid catabolic process (GO:0046479)2.88522674
146regulation of T cell tolerance induction (GO:0002664)2.88179766
147negative thymic T cell selection (GO:0045060)2.87560270
148interferon-gamma-mediated signaling pathway (GO:0060333)2.86835613
149positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85069801
150lysine catabolic process (GO:0006554)2.84902648
151lysine metabolic process (GO:0006553)2.84902648
152pyridine-containing compound biosynthetic process (GO:0072525)2.84077051
153aldehyde catabolic process (GO:0046185)2.83525269
154response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83207553
155response to host immune response (GO:0052572)2.83207553
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.83155399
157coenzyme catabolic process (GO:0009109)2.82961191
158negative regulation of leukocyte mediated immunity (GO:0002704)2.81190375
159positive regulation of mast cell activation (GO:0033005)2.79382609
160defense response to protozoan (GO:0042832)2.78426166
161regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77699433
162negative regulation of innate immune response (GO:0045824)2.77108903
163negative T cell selection (GO:0043383)2.75301025
164response to protozoan (GO:0001562)2.75293354
165negative regulation of T cell mediated immunity (GO:0002710)2.75247652
166negative regulation of interleukin-6 production (GO:0032715)2.73886987
167negative regulation of cytokine production involved in immune response (GO:0002719)2.72888148
168microglial cell activation (GO:0001774)2.71434902
169oligosaccharide catabolic process (GO:0009313)2.69428666
170regulation of tolerance induction (GO:0002643)2.69159557
171tolerance induction (GO:0002507)2.68895444
172T cell selection (GO:0045058)2.68725593
173response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66896712
174response to host (GO:0075136)2.66896712
175response to host defenses (GO:0052200)2.66896712
176positive regulation of mast cell activation involved in immune response (GO:0033008)2.65521657
177positive regulation of mast cell degranulation (GO:0043306)2.65521657
178regulation of regulated secretory pathway (GO:1903305)2.65124827
179myeloid dendritic cell differentiation (GO:0043011)2.65033752
180T-helper 1 type immune response (GO:0042088)2.61825110
181N-acetylneuraminate metabolic process (GO:0006054)2.61743245
182positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.60828026
183myeloid dendritic cell activation (GO:0001773)2.60279730
184B cell mediated immunity (GO:0019724)2.60101360
185glycolipid catabolic process (GO:0019377)2.57888684
186regulation of T-helper 2 cell differentiation (GO:0045628)2.55991290
187positive regulation of leukocyte degranulation (GO:0043302)2.54379250
188thymic T cell selection (GO:0045061)2.54150956
189positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52196046
190myeloid leukocyte activation (GO:0002274)2.52030116
191cellular response to thyroid hormone stimulus (GO:0097067)2.51691079
192positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51072644
193regulation of B cell differentiation (GO:0045577)2.49729204
194positive T cell selection (GO:0043368)2.48900091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.83246569
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.71610999
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.05609706
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.87800986
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.43412754
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.85745660
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.75644510
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.69020957
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.65525862
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.50030947
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.99438466
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.98278079
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.58750112
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56934077
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.54129788
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.50742253
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.49867889
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26568577
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15023738
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14966228
21MYC_22102868_ChIP-Seq_BL_Human2.14852629
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12308814
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07157221
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.07008251
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96186780
26RUNX_20019798_ChIP-Seq_JUKART_Human1.91715237
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87354957
28TCF7_22412390_ChIP-Seq_EML_Mouse1.87307344
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84965181
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83501068
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83217883
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81405947
33UTX_26944678_Chip-Seq_JUKART_Human1.79537448
34GATA1_22025678_ChIP-Seq_K562_Human1.75598489
35KDM2B_26808549_Chip-Seq_DND41_Human1.74794897
36MYB_26560356_Chip-Seq_TH2_Human1.71573199
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63762541
38MAF_26560356_Chip-Seq_TH2_Human1.59357117
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50501289
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47058194
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45806327
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45558773
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45442781
44GATA1_19941826_ChIP-Seq_K562_Human1.43727732
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41616378
46SCL_19346495_ChIP-Seq_HPC-7_Human1.40362209
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40135724
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39309736
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32933269
50RACK7_27058665_Chip-Seq_MCF-7_Human1.27230585
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25557678
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24320724
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22424851
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20103875
55SPI1_23547873_ChIP-Seq_NB4_Human1.19929170
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19842891
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18793788
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17427760
59GATA3_27048872_Chip-Seq_THYMUS_Human1.16535377
60NCOR1_26117541_ChIP-Seq_K562_Human1.13727221
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13631002
62PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13062152
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.12076091
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.10940494
65PU_27001747_Chip-Seq_BMDM_Mouse1.09908488
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09657827
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09199989
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.08834962
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08721141
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.08199930
71VDR_21846776_ChIP-Seq_THP-1_Human1.07267242
72P68_20966046_ChIP-Seq_HELA_Human1.07119390
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06881043
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05461036
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04992577
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04726535
77CLOCK_20551151_ChIP-Seq_293T_Human1.03422601
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.02775486
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02102920
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00640460
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00529336
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00362050
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00115172
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99978015
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98048297
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97379989
87GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96357757
88VDR_24763502_ChIP-Seq_THP-1_Human0.95052389
89HNF4A_19822575_ChIP-Seq_HepG2_Human0.94907012
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.94649926
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94374492
92KDM2B_26808549_Chip-Seq_K562_Human0.94323479
93SPI1_23127762_ChIP-Seq_K562_Human0.93545352
94MAF_26560356_Chip-Seq_TH1_Human0.93121494
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92506742
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.92179387
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92133602
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91491147
99GATA4_25053715_ChIP-Seq_YYC3_Human0.90621295
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89611501
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89600372
102FOXA2_19822575_ChIP-Seq_HepG2_Human0.89312652
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88862750
104SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88403431
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87564429
106MYB_26560356_Chip-Seq_TH1_Human0.87210606
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87136949
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.86457265
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86362404
110STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86167555
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82856201
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.82105503
113TP63_17297297_ChIP-ChIP_HaCaT_Human0.81931222
114LXR_22292898_ChIP-Seq_THP-1_Human0.80769262
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.79366796
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78605449
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76767370
118SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76174116
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75495752
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74394873
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73544538
122BCL6_27268052_Chip-Seq_Bcells_Human0.73476160
123BCOR_27268052_Chip-Seq_Bcells_Human0.72582834
124KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72144137
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71960742
126VDR_24787735_ChIP-Seq_THP-1_Human0.71715338
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70142867
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.69869001
129GATA2_19941826_ChIP-Seq_K562_Human0.69403371
130SPI1_20517297_ChIP-Seq_HL60_Human0.69261415
131CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68405537
132FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.66562534
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.66249242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.53466626
2MP0005360_urolithiasis4.73416020
3MP0005365_abnormal_bile_salt4.20248513
4MP0005085_abnormal_gallbladder_physiolo4.10784075
5MP0009840_abnormal_foam_cell3.92047824
6MP0008875_abnormal_xenobiotic_pharmacok3.26562084
7MP0003191_abnormal_cellular_cholesterol2.87992003
8MP0003252_abnormal_bile_duct2.79833183
9MP0010329_abnormal_lipoprotein_level2.73365288
10MP0003806_abnormal_nucleotide_metabolis2.70080223
11MP0005083_abnormal_biliary_tract2.27916540
12MP0005058_abnormal_lysosome_morphology2.26685056
13MP0003436_decreased_susceptibility_to2.24717261
14MP0001835_abnormal_antigen_presentation2.11591069
15MP0000609_abnormal_liver_physiology1.94507008
16MP0005332_abnormal_amino_acid1.94430093
17MP0003763_abnormal_thymus_physiology1.92913131
18MP0002419_abnormal_innate_immunity1.88427362
19MP0002138_abnormal_hepatobiliary_system1.84256138
20MP0009333_abnormal_splenocyte_physiolog1.82581219
21MP0005464_abnormal_platelet_physiology1.79581540
22MP0003195_calcinosis1.78134832
23MP0003303_peritoneal_inflammation1.77012819
24MP0004019_abnormal_vitamin_homeostasis1.76500153
25MP0009785_altered_susceptibility_to1.73966937
26MP0009764_decreased_sensitivity_to1.69054480
27MP0002998_abnormal_bone_remodeling1.68684073
28MP0003828_pulmonary_edema1.66365007
29MP0002118_abnormal_lipid_homeostasis1.64423551
30MP0005025_abnormal_response_to1.60330578
31MP0001666_abnormal_nutrient_absorption1.60244719
32MP0003724_increased_susceptibility_to1.59951213
33MP0002254_reproductive_system_inflammat1.59803790
34MP0005319_abnormal_enzyme/_coenzyme1.59437270
35MP0005670_abnormal_white_adipose1.53981697
36MP0003172_abnormal_lysosome_physiology1.51433128
37MP0003186_abnormal_redox_activity1.48966578
38MP0005451_abnormal_body_composition1.47807178
39MP0008469_abnormal_protein_level1.47380418
40MP0006082_CNS_inflammation1.45987317
41MP0002398_abnormal_bone_marrow1.43498589
42MP0003656_abnormal_erythrocyte_physiolo1.38936664
43MP0001764_abnormal_homeostasis1.35650145
44MP0001790_abnormal_immune_system1.35482295
45MP0005387_immune_system_phenotype1.35482295
46MP0000685_abnormal_immune_system1.34573590
47MP0005310_abnormal_salivary_gland1.32807357
48MP0009763_increased_sensitivity_to1.28888001
49MP0001853_heart_inflammation1.28104042
50MP0002148_abnormal_hypersensitivity_rea1.26473775
51MP0001851_eye_inflammation1.25629818
52MP0001800_abnormal_humoral_immune1.24634838
53MP0009278_abnormal_bone_marrow1.22527047
54MP0002452_abnormal_antigen_presenting1.19920140
55MP0005000_abnormal_immune_tolerance1.19212313
56MP0004947_skin_inflammation1.19037202
57MP0001845_abnormal_inflammatory_respons1.18952204
58MP0002933_joint_inflammation1.17052509
59MP0003183_abnormal_peptide_metabolism1.14789609
60MP0003705_abnormal_hypodermis_morpholog1.14650225
61MP0000598_abnormal_liver_morphology1.14252275
62MP0005584_abnormal_enzyme/coenzyme_acti1.14199184
63MP0001873_stomach_inflammation1.14173232
64MP0002723_abnormal_immune_serum1.13256741
65MP0000604_amyloidosis1.12434166
66MP0004883_abnormal_blood_vessel1.09519143
67MP0001533_abnormal_skeleton_physiology1.09420116
68MP0005166_decreased_susceptibility_to1.09078493
69MP0003690_abnormal_glial_cell1.08919316
70MP0009643_abnormal_urine_homeostasis1.08537860
71MP0000569_abnormal_digit_pigmentation1.07630036
72MP0003011_delayed_dark_adaptation1.06711403
73MP0005164_abnormal_response_to1.06577420
74MP0008004_abnormal_stomach_pH1.03799060
75MP0003866_abnormal_defecation1.02805588
76MP0008260_abnormal_autophagy1.02089300
77MP0000703_abnormal_thymus_morphology1.02025438
78MP0005390_skeleton_phenotype0.98074805
79MP0003329_amyloid_beta_deposits0.97761600
80MP0005075_abnormal_melanosome_morpholog0.96004729
81MP0000343_altered_response_to0.94519381
82MP0001819_abnormal_immune_cell0.93807819
83MP0001545_abnormal_hematopoietic_system0.92857772
84MP0005397_hematopoietic_system_phenotyp0.92857772
85MP0003279_aneurysm0.91941231
86MP0002420_abnormal_adaptive_immunity0.91692551
87MP0003868_abnormal_feces_composition0.91296174
88MP0003091_abnormal_cell_migration0.90555538
89MP0003075_altered_response_to0.88817075
90MP0005167_abnormal_blood-brain_barrier0.88788040
91MP0005076_abnormal_cell_differentiation0.87904256
92MP0010155_abnormal_intestine_physiology0.86334450
93MP0004782_abnormal_surfactant_physiolog0.85744105
94MP0004808_abnormal_hematopoietic_stem0.85008061
95MP0003795_abnormal_bone_structure0.84743041
96MP0009697_abnormal_copulation0.84585874
97MP0004510_myositis0.84368896
98MP0003300_gastrointestinal_ulcer0.83344119
99MP0002396_abnormal_hematopoietic_system0.83241400
100MP0004381_abnormal_hair_follicle0.82224417
101MP0002405_respiratory_system_inflammati0.81760271
102MP0005647_abnormal_sex_gland0.81724175
103MP0001663_abnormal_digestive_system0.80329333
104MP0003566_abnormal_cell_adhesion0.79917714
105MP0009765_abnormal_xenobiotic_induced0.78811836
106MP0000689_abnormal_spleen_morphology0.78346016
107MP0009642_abnormal_blood_homeostasis0.77133126
108MP0002136_abnormal_kidney_physiology0.76253847
109MP0002132_abnormal_respiratory_system0.75192864
110MP0005671_abnormal_response_to0.74567787
111MP0000371_diluted_coat_color0.73972779
112MP0002166_altered_tumor_susceptibility0.73248562
113MP0000716_abnormal_immune_system0.71385501
114MP0003453_abnormal_keratinocyte_physiol0.71124945
115MP0002971_abnormal_brown_adipose0.69968534
116MP0000249_abnormal_blood_vessel0.69885825
117MP0009115_abnormal_fat_cell0.67927497
118MP0005165_increased_susceptibility_to0.67566490
119MP0005334_abnormal_fat_pad0.67517710
120MP0003448_altered_tumor_morphology0.67432774
121MP0000465_gastrointestinal_hemorrhage0.67086313
122MP0008874_decreased_physiological_sensi0.66544088
123MP0001849_ear_inflammation0.66005840
124MP0005023_abnormal_wound_healing0.65840586
125MP0005174_abnormal_tail_pigmentation0.65156360
126MP0000858_altered_metastatic_potential0.63442587
127MP0004130_abnormal_muscle_cell0.62999680
128MP0002429_abnormal_blood_cell0.62502105
129MP0002722_abnormal_immune_system0.62169425
130MP0004858_abnormal_nervous_system0.61078846
131MP0002332_abnormal_exercise_endurance0.60754796
132MP0002877_abnormal_melanocyte_morpholog0.59825440

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.34198359
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.34198359
3Abnormality of glycolipid metabolism (HP:0010969)5.34198359
4Deep venous thrombosis (HP:0002625)5.05863836
5Joint hemorrhage (HP:0005261)4.94316260
6Xanthomatosis (HP:0000991)4.91065317
7Prolonged partial thromboplastin time (HP:0003645)4.90218992
8Intrahepatic cholestasis (HP:0001406)4.85986291
9Complement deficiency (HP:0004431)4.79830680
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.71335486
11Recurrent gram-negative bacterial infections (HP:0005420)4.69078537
12Abnormality of aromatic amino acid family metabolism (HP:0004338)4.63938761
13Hyperlipoproteinemia (HP:0010980)4.59025926
14Systemic lupus erythematosus (HP:0002725)4.29215000
15Myocardial infarction (HP:0001658)4.08872918
16Abnormality of complement system (HP:0005339)4.00053687
17Recurrent bacterial skin infections (HP:0005406)3.77317426
18Recurrent abscess formation (HP:0002722)3.74468601
19Loss of speech (HP:0002371)3.70653499
20Hypobetalipoproteinemia (HP:0003563)3.58343955
21Stomatitis (HP:0010280)3.56122388
22Abnormality of pyrimidine metabolism (HP:0004353)3.56085706
23Eczematoid dermatitis (HP:0000976)3.55464230
24Glomerulonephritis (HP:0000099)3.54137978
25Hypoalphalipoproteinemia (HP:0003233)3.46209017
26Epidermoid cyst (HP:0200040)3.45178842
27Abnormality of the common coagulation pathway (HP:0010990)3.37687292
28Hyperglycinuria (HP:0003108)3.34530812
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.28500921
30Hypolipoproteinemia (HP:0010981)3.25156378
31Optic neuritis (HP:0100653)3.24028941
32Retrobulbar optic neuritis (HP:0100654)3.24028941
33Hyperglycinemia (HP:0002154)3.21274103
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.20112046
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.19079385
36Hypercholesterolemia (HP:0003124)3.18902387
37Gingival bleeding (HP:0000225)3.13366304
38Vacuolated lymphocytes (HP:0001922)3.10462173
39Hyperammonemia (HP:0001987)3.07438350
40Abnormality of serine family amino acid metabolism (HP:0010894)2.99942955
41Abnormality of glycine metabolism (HP:0010895)2.99942955
42Abnormality of methionine metabolism (HP:0010901)2.95514640
43Increased IgE level (HP:0003212)2.89042183
44Amyloidosis (HP:0011034)2.89011944
45Abnormality of macrophages (HP:0004311)2.81955453
46Fat malabsorption (HP:0002630)2.74369826
47Meningitis (HP:0001287)2.71370745
48Abnormality of the intrinsic pathway (HP:0010989)2.70891615
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65381631
50Pulmonary infiltrates (HP:0002113)2.61253332
51Nephritis (HP:0000123)2.61180783
52Pustule (HP:0200039)2.60730400
53Recurrent skin infections (HP:0001581)2.58278985
54Cellulitis (HP:0100658)2.58240763
55Abnormality of nucleobase metabolism (HP:0010932)2.58018987
56Chronic mucocutaneous candidiasis (HP:0002728)2.55956098
57Recurrent cutaneous fungal infections (HP:0011370)2.55956098
58Abnormality of fatty-acid metabolism (HP:0004359)2.55229928
59Gastrointestinal infarctions (HP:0005244)2.53570012
60Ketosis (HP:0001946)2.50905314
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.50825197
62Vasculitis (HP:0002633)2.48853124
63Gingivitis (HP:0000230)2.48384598
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.47984324
65Menorrhagia (HP:0000132)2.47046524
66Axonal loss (HP:0003447)2.47028023
67Hemoptysis (HP:0002105)2.46808480
68Conjugated hyperbilirubinemia (HP:0002908)2.43748965
69Hypoglycemic coma (HP:0001325)2.42067556
70Petechiae (HP:0000967)2.39926773
71Recurrent viral infections (HP:0004429)2.39396612
72Esophageal varix (HP:0002040)2.39049440
73Purpura (HP:0000979)2.36786554
74Keratoconjunctivitis sicca (HP:0001097)2.36704373
75Hepatosplenomegaly (HP:0001433)2.36521478
76Inflammation of the large intestine (HP:0002037)2.35068149
77Periodontitis (HP:0000704)2.34863146
78Disinhibition (HP:0000734)2.34709507
79T lymphocytopenia (HP:0005403)2.32075787
80Gastrointestinal inflammation (HP:0004386)2.31614341
81Colitis (HP:0002583)2.31459747
82Steatorrhea (HP:0002570)2.30199041
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28433560
84Abnormality of iron homeostasis (HP:0011031)2.28260558
85Increased cerebral lipofuscin (HP:0011813)2.27299353
86Interstitial pulmonary disease (HP:0006530)2.27220773
87Epistaxis (HP:0000421)2.25570011
88Hematochezia (HP:0002573)2.24449910
89Encephalitis (HP:0002383)2.24180234
90Autoimmune thrombocytopenia (HP:0001973)2.23984997
91Asymmetric septal hypertrophy (HP:0001670)2.21146577
92Prolonged bleeding time (HP:0003010)2.20940950
93Thrombophlebitis (HP:0004418)2.19663795
94Urticaria (HP:0001025)2.18980390
95Vascular calcification (HP:0004934)2.18932706
96Malnutrition (HP:0004395)2.17909156
97Neurofibrillary tangles (HP:0002185)2.16478628
98Abnormality of serum amino acid levels (HP:0003112)2.16377835
99Chest pain (HP:0100749)2.15387265
100Skin nodule (HP:0200036)2.15213480
101Abnormality of T cell number (HP:0011839)2.14764632
102Keratoconjunctivitis (HP:0001096)2.14306439
103Mediastinal lymphadenopathy (HP:0100721)2.14176948
104Mitral stenosis (HP:0001718)2.13479701
105Upper motor neuron abnormality (HP:0002127)2.13409144
106Hypochromic microcytic anemia (HP:0004840)2.13050610
107Granulocytopenia (HP:0001913)2.11816042
108Premature loss of primary teeth (HP:0006323)2.11225699
109Increased serum ferritin (HP:0003281)2.11200592
110Leukocytosis (HP:0001974)2.10630421
111Abnormality of purine metabolism (HP:0004352)2.08985627
112Nausea (HP:0002018)2.08878744
113Myositis (HP:0100614)2.08009416
114Spontaneous hematomas (HP:0007420)2.07754333
115Pulmonary embolism (HP:0002204)2.06246121
116Abnormality of transition element cation homeostasis (HP:0011030)2.06245254
117Urinary glycosaminoglycan excretion (HP:0003541)2.06045228
118Mucopolysacchariduria (HP:0008155)2.06045228
119Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05267469
120Abnormality of polysaccharide metabolism (HP:0011012)2.05267469
121Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05267469
122Hydroxyprolinuria (HP:0003080)2.04443143
123Abnormality of proline metabolism (HP:0010907)2.04443143
124Osteomyelitis (HP:0002754)2.03226385
125Orchitis (HP:0100796)2.02544287
126Progressive neurologic deterioration (HP:0002344)2.01553193
127Renal cortical cysts (HP:0000803)2.01219278
128Mutism (HP:0002300)2.00605534
129Chronic obstructive pulmonary disease (HP:0006510)2.00163214
130Obstructive lung disease (HP:0006536)2.00163214
131Abnormal enzyme/coenzyme activity (HP:0012379)1.99700215
132Episodic fever (HP:0001954)1.99017577
133Hepatocellular carcinoma (HP:0001402)1.98746739
134Pancreatitis (HP:0001733)1.98109793
135Increased IgM level (HP:0003496)1.97542254
136Hypergammaglobulinemia (HP:0010702)1.97304595
137Increased neuronal autofluorescent lipopigment (HP:0002074)1.96960889
138Recurrent fungal infections (HP:0002841)1.96877846
139Elevated erythrocyte sedimentation rate (HP:0003565)1.96211010
140Hemorrhage of the eye (HP:0011885)1.96137540
141Neuronal loss in central nervous system (HP:0002529)1.95561158
142Hyperbilirubinemia (HP:0002904)1.93874317
143Dysostosis multiplex (HP:0000943)1.93769267
144Hypertriglyceridemia (HP:0002155)1.91128648
145Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90359602
146Dicarboxylic aciduria (HP:0003215)1.90359602
147Anorexia (HP:0002039)1.89274982
148Elevated alkaline phosphatase (HP:0003155)1.87778361
149Cardiovascular calcification (HP:0011915)1.86957325
150Abnormality of T cells (HP:0002843)1.85975873
151Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85834030
152Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83846672
153Arterial thrombosis (HP:0004420)1.81756160
154Spondylolisthesis (HP:0003302)1.81038127
155Polycythemia (HP:0001901)1.80739092
156Thoracic kyphosis (HP:0002942)1.78805212
157Restrictive lung disease (HP:0002091)1.78020508
158Hypertensive crisis (HP:0100735)1.77991355
159Polygenic inheritance (HP:0010982)1.75802359
160Autoimmune hemolytic anemia (HP:0001890)1.75126651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.86710797
2ERN13.47822391
3BCKDK3.29966657
4IRAK42.95012367
5TAOK32.82682447
6TYK22.78342996
7PRPF4B2.76802025
8MAP3K142.74722203
9TBK12.72590942
10FGFR42.34195768
11BLK2.21961720
12SIK12.09903897
13KIT2.09435341
14ZAK2.08100384
15MAP4K11.93076351
16CSK1.78202090
17IKBKE1.76376585
18JAK11.63107310
19TNK21.62544732
20EPHB11.60115840
21MAP3K131.59399122
22IKBKB1.58589819
23MAP2K31.57732186
24CSF1R1.49448163
25TESK21.46683133
26TRIB31.42180254
27MST1R1.38784423
28TAOK11.34437871
29INSRR1.32785556
30GRK61.32050616
31MATK1.28415905
32GRK71.27830281
33JAK31.26777360
34TGFBR21.26687183
35PTK61.26519179
36MAP3K11.23445553
37CDK121.21699808
38ZAP701.21681476
39NEK91.21599040
40FLT31.20457012
41CDC42BPA1.17451871
42CAMK1D1.16310787
43PKN21.15837594
44BTK1.15757769
45RIPK41.13168681
46EPHA21.12198406
47PIM11.07752844
48TEC1.05629960
49STK31.05558864
50PIK3CG1.03870565
51TXK1.03009454
52JAK21.01900443
53CHUK1.00165652
54SIK30.99653316
55SMG10.99506640
56MARK20.97636833
57HCK0.97011438
58MAPK110.95807939
59STK100.95518620
60MAP3K30.94802294
61TTK0.93374999
62EIF2AK20.89520946
63PIM20.88612543
64MAP3K110.86812165
65CDK60.84467929
66LYN0.81251745
67HIPK20.81097923
68PDK10.78333631
69PRKAA20.78022878
70MAP2K60.77623764
71MARK30.76173063
72ABL20.76031209
73PRKD20.75547997
74CAMKK20.74808794
75RPS6KL10.73859374
76RPS6KC10.73859374
77TAOK20.72825646
78TRPM70.70892184
79ERBB40.69580190
80KSR20.68934740
81CDK40.68450565
82MOS0.67181633
83EPHA30.65825864
84GRK10.65558701
85TTN0.65290358
86MAP2K20.64709230
87NUAK10.64071881
88NME20.63701555
89SYK0.63167011
90AKT30.63074379
91RPS6KA20.62754057
92IRAK10.62753570
93FGR0.61900646
94MAPK40.61225189
95BMX0.60792488
96LCK0.60273022
97ICK0.60097755
98MAP3K70.59300253
99ABL10.58664809
100TIE10.58556086
101FES0.56351554
102KDR0.54633711
103CAMKK10.54005965
104LATS10.52841218
105MAPK70.52024120
106STK40.51662010
107RPS6KA40.50957159
108ACVR1B0.50027085
109CLK10.48170357
110DDR20.48026186
111MAP3K100.47878129
112IRAK20.47749139
113PINK10.46908822
114PRKCD0.46504233
115RIPK10.45839192
116MAPKAPK20.44930360
117MAPK120.43355971
118FGFR30.43336791
119GSK3A0.43071867
120PAK40.42385205
121SGK30.41731205
122BMPR20.41390707
123TESK10.41135525
124RPS6KA60.40549015
125MAP3K60.39623334
126YES10.39539424
127MAP3K50.39400635
128EGFR0.38721676
129NLK0.38436049
130PDPK10.36942818
131PRKG20.36924096
132ITK0.36922159
133NEK20.36571054
134SIK20.36218111
135MTOR0.34855083

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.70480139
2Staphylococcus aureus infection_Homo sapiens_hsa051503.22985694
3Complement and coagulation cascades_Homo sapiens_hsa046103.02750309
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.80466604
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43085416
6Arginine biosynthesis_Homo sapiens_hsa002202.41936043
7Tryptophan metabolism_Homo sapiens_hsa003802.41792981
8Nitrogen metabolism_Homo sapiens_hsa009102.38957686
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36162506
10Caffeine metabolism_Homo sapiens_hsa002322.27757442
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19918350
12Fatty acid degradation_Homo sapiens_hsa000712.12777218
13Allograft rejection_Homo sapiens_hsa053302.07023315
14Vitamin B6 metabolism_Homo sapiens_hsa007502.01237767
15Histidine metabolism_Homo sapiens_hsa003401.96111493
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95868651
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92896214
18Graft-versus-host disease_Homo sapiens_hsa053321.91960607
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88227601
20PPAR signaling pathway_Homo sapiens_hsa033201.86176174
21Autoimmune thyroid disease_Homo sapiens_hsa053201.84959040
22Peroxisome_Homo sapiens_hsa041461.84724179
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.75735171
24beta-Alanine metabolism_Homo sapiens_hsa004101.75592609
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72695083
26Acute myeloid leukemia_Homo sapiens_hsa052211.68605457
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68234181
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66931661
29Rheumatoid arthritis_Homo sapiens_hsa053231.63630999
30Chemical carcinogenesis_Homo sapiens_hsa052041.63332473
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.61197896
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60308928
33Hematopoietic cell lineage_Homo sapiens_hsa046401.58916512
34Asthma_Homo sapiens_hsa053101.58916074
35Primary immunodeficiency_Homo sapiens_hsa053401.57498394
36Retinol metabolism_Homo sapiens_hsa008301.56439513
37Antigen processing and presentation_Homo sapiens_hsa046121.53627936
38ABC transporters_Homo sapiens_hsa020101.50308645
39Fatty acid metabolism_Homo sapiens_hsa012121.46846435
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46556720
41Selenocompound metabolism_Homo sapiens_hsa004501.45445848
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39660579
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39019144
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38344370
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37692831
46Phagosome_Homo sapiens_hsa041451.36705330
47Folate biosynthesis_Homo sapiens_hsa007901.34725006
48Starch and sucrose metabolism_Homo sapiens_hsa005001.34280798
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33908430
50Phenylalanine metabolism_Homo sapiens_hsa003601.33589990
51T cell receptor signaling pathway_Homo sapiens_hsa046601.30656469
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.29489933
53Type I diabetes mellitus_Homo sapiens_hsa049401.27535010
54Propanoate metabolism_Homo sapiens_hsa006401.24086764
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22785007
56Vitamin digestion and absorption_Homo sapiens_hsa049771.22435251
57Viral myocarditis_Homo sapiens_hsa054161.21957100
58Chemokine signaling pathway_Homo sapiens_hsa040621.20222088
59Steroid biosynthesis_Homo sapiens_hsa001001.19271526
60Butanoate metabolism_Homo sapiens_hsa006501.17146255
61Sulfur relay system_Homo sapiens_hsa041221.12401094
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.12085085
63One carbon pool by folate_Homo sapiens_hsa006701.10172594
64Tyrosine metabolism_Homo sapiens_hsa003501.08208132
65Pentose phosphate pathway_Homo sapiens_hsa000301.08095410
66Leukocyte transendothelial migration_Homo sapiens_hsa046701.07913164
67Salmonella infection_Homo sapiens_hsa051321.06300073
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05802131
69Hepatitis B_Homo sapiens_hsa051611.02783768
70Shigellosis_Homo sapiens_hsa051310.99371549
71Bile secretion_Homo sapiens_hsa049760.98915965
72Lysosome_Homo sapiens_hsa041420.96190450
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96144813
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94611624
75Other glycan degradation_Homo sapiens_hsa005110.94245283
76Lysine degradation_Homo sapiens_hsa003100.93524813
77VEGF signaling pathway_Homo sapiens_hsa043700.93335509
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92241743
79Leishmaniasis_Homo sapiens_hsa051400.91263481
80Fat digestion and absorption_Homo sapiens_hsa049750.90787934
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88892440
82Biosynthesis of amino acids_Homo sapiens_hsa012300.88881270
83Platelet activation_Homo sapiens_hsa046110.88312810
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87288692
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87255748
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86480727
87Fatty acid elongation_Homo sapiens_hsa000620.85062221
88Chronic myeloid leukemia_Homo sapiens_hsa052200.84590358
89Carbon metabolism_Homo sapiens_hsa012000.84200697
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.84053551
91Arginine and proline metabolism_Homo sapiens_hsa003300.83882525
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.83022489
93Pancreatic cancer_Homo sapiens_hsa052120.81198085
94Non-small cell lung cancer_Homo sapiens_hsa052230.75855251
95Glycerolipid metabolism_Homo sapiens_hsa005610.74410386
96Pertussis_Homo sapiens_hsa051330.72288511
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71472138
98Amoebiasis_Homo sapiens_hsa051460.70854948
99Sulfur metabolism_Homo sapiens_hsa009200.70849159
100Prolactin signaling pathway_Homo sapiens_hsa049170.70531966
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.66860341
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66464299
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.65739025
104Endocytosis_Homo sapiens_hsa041440.64894476
105Fatty acid biosynthesis_Homo sapiens_hsa000610.62949254
106Legionellosis_Homo sapiens_hsa051340.62821464
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61542350
108Malaria_Homo sapiens_hsa051440.60427929
109Notch signaling pathway_Homo sapiens_hsa043300.60215183
110Glutathione metabolism_Homo sapiens_hsa004800.59915226
111Bladder cancer_Homo sapiens_hsa052190.59545648
112Fructose and mannose metabolism_Homo sapiens_hsa000510.58800647
113Galactose metabolism_Homo sapiens_hsa000520.57904445
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.56310164
115Epstein-Barr virus infection_Homo sapiens_hsa051690.55622651
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55008291
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54756186
118Renal cell carcinoma_Homo sapiens_hsa052110.54729962
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.54356143
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54306130
121Osteoclast differentiation_Homo sapiens_hsa043800.53637015
122HTLV-I infection_Homo sapiens_hsa051660.52283752
123Pyruvate metabolism_Homo sapiens_hsa006200.52204644
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50424693
125Collecting duct acid secretion_Homo sapiens_hsa049660.50038202
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48469702
127GnRH signaling pathway_Homo sapiens_hsa049120.47830403
128Measles_Homo sapiens_hsa051620.47560512
129Viral carcinogenesis_Homo sapiens_hsa052030.47486962
130Sphingolipid metabolism_Homo sapiens_hsa006000.47241746
131HIF-1 signaling pathway_Homo sapiens_hsa040660.46880690
132Tuberculosis_Homo sapiens_hsa051520.46746027
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43294253
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.43084567
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.41920410
136Choline metabolism in cancer_Homo sapiens_hsa052310.40913223
137Influenza A_Homo sapiens_hsa051640.39181003
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38586471
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38138686
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37670315
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37461351
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37221935
143mTOR signaling pathway_Homo sapiens_hsa041500.37198172
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37063294
145FoxO signaling pathway_Homo sapiens_hsa040680.36758801
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36344466
147Insulin resistance_Homo sapiens_hsa049310.35423868
148Metabolic pathways_Homo sapiens_hsa011000.35107343
149Cyanoamino acid metabolism_Homo sapiens_hsa004600.34907114
150Inositol phosphate metabolism_Homo sapiens_hsa005620.34285892
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34237838
152Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33610115
153Apoptosis_Homo sapiens_hsa042100.32817436
154Hepatitis C_Homo sapiens_hsa051600.32455839
155MAPK signaling pathway_Homo sapiens_hsa040100.30049932
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.28908104
157Arachidonic acid metabolism_Homo sapiens_hsa005900.27953587
158Herpes simplex infection_Homo sapiens_hsa051680.26882860
159African trypanosomiasis_Homo sapiens_hsa051430.26821759
160alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24651394
161TNF signaling pathway_Homo sapiens_hsa046680.23390210
162Prion diseases_Homo sapiens_hsa050200.22774742
163B cell receptor signaling pathway_Homo sapiens_hsa046620.22604483
164Toxoplasmosis_Homo sapiens_hsa051450.21738713

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