SLC9A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sodium-hydrogen exchanger (NHE) protein family. These proteins are involved in sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and help in the regulation of cell pH and volume. The encoded protein is localized to the apical membrane and is involved in apical absorption of sodium. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UDP-N-acetylglucosamine metabolic process (GO:0006047)6.61650569
2angiotensin maturation (GO:0002003)5.98714392
3intestinal absorption (GO:0050892)5.77171378
4bundle of His cell to Purkinje myocyte communication (GO:0086069)5.75279570
5Golgi transport vesicle coating (GO:0048200)5.12516316
6COPI coating of Golgi vesicle (GO:0048205)5.12516316
7intestinal epithelial cell development (GO:0060576)5.11428910
8sulfate transmembrane transport (GO:1902358)5.04775660
9vitamin transmembrane transport (GO:0035461)5.04429753
10biotin metabolic process (GO:0006768)5.03787095
11carnitine shuttle (GO:0006853)4.88500731
12actin filament depolymerization (GO:0030042)4.70925919
13NADH metabolic process (GO:0006734)4.67057183
14pyrimidine-containing compound transmembrane transport (GO:0072531)4.64485952
15maintenance of gastrointestinal epithelium (GO:0030277)4.58413205
16sulfur compound transport (GO:0072348)4.31580240
17regulation of fatty acid beta-oxidation (GO:0031998)4.30917821
183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.29855528
19purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.29855528
20epithelial cell maturation (GO:0002070)4.26633957
21positive regulation of fatty acid beta-oxidation (GO:0032000)4.23080702
22positive regulation of keratinocyte differentiation (GO:0045618)4.21120503
23bile acid and bile salt transport (GO:0015721)4.21027514
24carnitine transmembrane transport (GO:1902603)4.12989917
25regulation of water loss via skin (GO:0033561)4.10504511
26desmosome organization (GO:0002934)4.06812395
27sulfate transport (GO:0008272)3.96920879
28branching involved in mammary gland duct morphogenesis (GO:0060444)3.94532817
29artery development (GO:0060840)3.93846962
30regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.92580603
31galactose catabolic process (GO:0019388)3.91033025
32iron ion import (GO:0097286)3.88085276
33branching involved in prostate gland morphogenesis (GO:0060442)3.77369841
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.75080700
35flavonoid metabolic process (GO:0009812)3.74468466
36epithelial structure maintenance (GO:0010669)3.74219152
37O-glycan processing (GO:0016266)3.71924118
38response to food (GO:0032094)3.68637608
39sulfur amino acid catabolic process (GO:0000098)3.65948566
40fatty acid transmembrane transport (GO:1902001)3.64654713
41positive regulation of glycoprotein biosynthetic process (GO:0010560)3.59878217
42positive regulation of glycoprotein metabolic process (GO:1903020)3.58705151
43skeletal muscle contraction (GO:0003009)3.54869751
44intestinal cholesterol absorption (GO:0030299)3.54174079
45digestive system process (GO:0022600)3.53369912
46hypotonic response (GO:0006971)3.53215706
47drug catabolic process (GO:0042737)3.49412334
48positive regulation of epidermal cell differentiation (GO:0045606)3.48718846
49fucose catabolic process (GO:0019317)3.47981192
50L-fucose metabolic process (GO:0042354)3.47981192
51L-fucose catabolic process (GO:0042355)3.47981192
52skeletal muscle adaptation (GO:0043501)3.46184027
53drug transmembrane transport (GO:0006855)3.43509153
54prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.43003778
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.41141835
56creatine metabolic process (GO:0006600)3.39413474
57hemidesmosome assembly (GO:0031581)3.38600076
58regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.38367355
59ventricular cardiac muscle cell action potential (GO:0086005)3.35492480
60regulation of bile acid biosynthetic process (GO:0070857)3.35270380
61positive regulation of Cdc42 GTPase activity (GO:0043089)3.34897462
62positive regulation of fatty acid oxidation (GO:0046321)3.34589508
63tight junction assembly (GO:0070830)3.34214164
64nucleotide-sugar biosynthetic process (GO:0009226)3.33691190
65negative regulation of cell size (GO:0045792)3.33462163
66cell communication involved in cardiac conduction (GO:0086065)3.32846279
67tricarboxylic acid cycle (GO:0006099)3.32686807
68multicellular organismal water homeostasis (GO:0050891)3.31821983
69nucleotide-sugar metabolic process (GO:0009225)3.28301448
70response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.28256971
71striated muscle atrophy (GO:0014891)3.26566303
72maternal placenta development (GO:0001893)3.25827268
73protein targeting to Golgi (GO:0000042)3.23854834
74COPII vesicle coating (GO:0048208)3.23010836
75ear development (GO:0043583)3.21854426
76proline biosynthetic process (GO:0006561)3.21139957
77bicarbonate transport (GO:0015701)3.21135128
78transcytosis (GO:0045056)3.20750178
79vitamin A metabolic process (GO:0006776)3.20400598
80calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.18999550
81trophectodermal cell differentiation (GO:0001829)3.17968790
82fucose metabolic process (GO:0006004)3.16520394
83mammary gland alveolus development (GO:0060749)3.16467155
84quaternary ammonium group transport (GO:0015697)3.16115416
85epithelial cell differentiation involved in prostate gland development (GO:0060742)3.12008520
86N-glycan processing (GO:0006491)3.09407557
87drug transport (GO:0015893)3.09143095
88regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.07667057
89regulation of fatty acid oxidation (GO:0046320)3.07290723
90ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.97637672
91nucleoside bisphosphate biosynthetic process (GO:0033866)2.97637672
92purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.97637672
93sodium ion export (GO:0071436)2.97492672
94insulin-like growth factor receptor signaling pathway (GO:0048009)2.97266497
95establishment of skin barrier (GO:0061436)2.96957316
96hormone catabolic process (GO:0042447)2.96137034
97mammary gland epithelial cell differentiation (GO:0060644)2.91770729
98adhesion of symbiont to host cell (GO:0044650)2.90176715
99virion attachment to host cell (GO:0019062)2.90176715
100establishment of protein localization to Golgi (GO:0072600)2.88713584
101retrograde transport, vesicle recycling within Golgi (GO:0000301)2.88335994
102purine nucleotide transport (GO:0015865)2.87714565
103cellular glucuronidation (GO:0052695)2.86555430
104pyrimidine ribonucleoside catabolic process (GO:0046133)2.85469222
105regulation of keratinocyte differentiation (GO:0045616)2.84731643
106lung secretory cell differentiation (GO:0061140)2.84513195
107exogenous drug catabolic process (GO:0042738)2.84420043
108modified amino acid transport (GO:0072337)2.82262247
109amyloid precursor protein catabolic process (GO:0042987)2.81882179
110cellular potassium ion homeostasis (GO:0030007)2.80828311
111transepithelial transport (GO:0070633)2.80151610
112regulation of protein localization to cell surface (GO:2000008)2.78791486
113ER overload response (GO:0006983)2.77442623
114membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.76481505
115water homeostasis (GO:0030104)2.75382083
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.75347425
117sulfation (GO:0051923)2.75305970
118sperm capacitation (GO:0048240)2.74498220
119muscle atrophy (GO:0014889)2.73858173
120digestion (GO:0007586)2.73649781
121galactose metabolic process (GO:0006012)2.73055672
122fructose metabolic process (GO:0006000)2.72941603
123regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.72117779
124phosphate ion transmembrane transport (GO:0035435)2.71779867
125muscle filament sliding (GO:0030049)2.71777119
126actin-myosin filament sliding (GO:0033275)2.71777119
127phosphatidylcholine biosynthetic process (GO:0006656)2.71316223
128hepatocyte apoptotic process (GO:0097284)2.71253454
129relaxation of cardiac muscle (GO:0055119)2.70971068
130oxaloacetate metabolic process (GO:0006107)2.70382005
131renal absorption (GO:0070293)2.70326145
132amyloid precursor protein metabolic process (GO:0042982)2.70101193
133beta-amyloid metabolic process (GO:0050435)2.69652104
134columnar/cuboidal epithelial cell development (GO:0002066)2.67881649
135regulation of cholesterol homeostasis (GO:2000188)2.67859160
136thrombin receptor signaling pathway (GO:0070493)2.67262229
137regulation of actin nucleation (GO:0051125)2.67151593
138oligosaccharide biosynthetic process (GO:0009312)2.66540075
139endoplasmic reticulum organization (GO:0007029)2.66202811
140sarcoplasmic reticulum calcium ion transport (GO:0070296)2.65697279
141potassium ion homeostasis (GO:0055075)2.64826372
142embryonic camera-type eye morphogenesis (GO:0048596)2.64672582
143glandular epithelial cell differentiation (GO:0002067)2.64271274
144regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.63612715
145peptide catabolic process (GO:0043171)2.61922600
146one-carbon metabolic process (GO:0006730)2.61864371
147auditory receptor cell differentiation (GO:0042491)2.61858326
148epithelial cell-cell adhesion (GO:0090136)2.61390553
149renal system process involved in regulation of blood volume (GO:0001977)2.61079863
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.60693690
151uronic acid metabolic process (GO:0006063)2.60404829
152glucuronate metabolic process (GO:0019585)2.60404829
153macroautophagy (GO:0016236)2.58899118
154cardiac conduction (GO:0061337)2.57905250
155phosphate ion transport (GO:0006817)2.56919847
156regulation of protein glycosylation (GO:0060049)2.55824745
157regulation of glucose import in response to insulin stimulus (GO:2001273)2.55076756
158gap junction assembly (GO:0016264)2.54456471
159activation of Rac GTPase activity (GO:0032863)2.54116536
160regulation of heart rate by cardiac conduction (GO:0086091)2.53067810
161positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.53059519
162peptidyl-tyrosine autophosphorylation (GO:0038083)2.52362548
163membrane repolarization during action potential (GO:0086011)2.47401879
164cGMP-mediated signaling (GO:0019934)2.46996685
165amino-acid betaine transport (GO:0015838)2.45423740
166carnitine transport (GO:0015879)2.45423740
167neurotransmitter biosynthetic process (GO:0042136)2.44952722
168* regulation of pH (GO:0006885)2.43587259
169vitamin transport (GO:0051180)2.43537285
170oligosaccharide catabolic process (GO:0009313)2.43372228
171phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.42225310
172protein O-linked glycosylation (GO:0006493)2.41888037
173negative regulation of sterol transport (GO:0032372)2.40703527
174negative regulation of cholesterol transport (GO:0032375)2.40703527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.27110428
2CDX2_20551321_ChIP-Seq_CACO-2_Human3.51853716
3AR_21909140_ChIP-Seq_LNCAP_Human3.51543066
4ESR1_15608294_ChIP-ChIP_MCF-7_Human3.41254157
5* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.20785474
6CDX2_19796622_ChIP-Seq_MESCs_Mouse3.17762942
7SOX2_20726797_ChIP-Seq_SW620_Human2.65022023
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.31698818
9GATA4_25053715_ChIP-Seq_YYC3_Human2.26424281
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.22609151
11* GATA6_25053715_ChIP-Seq_YYC3_Human2.08940696
12* CHD1_26751641_Chip-Seq_LNCaP_Human2.07051272
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.02652073
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.02131290
15* ESR2_21235772_ChIP-Seq_MCF-7_Human1.95534502
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87441972
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83782022
18* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79502304
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78845179
20ELF5_23300383_ChIP-Seq_T47D_Human1.76830864
21RUNX1_27514584_Chip-Seq_MCF-7_Human1.76569263
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.76427504
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73872366
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70887819
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68573188
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65299010
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64033592
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61395725
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60527071
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59554339
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58138907
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.57128648
33AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.54683098
34* KLF5_25053715_ChIP-Seq_YYC3_Human1.48885005
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.48666981
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48331843
37RACK7_27058665_Chip-Seq_MCF-7_Human1.44165896
38DROSHA_22980978_ChIP-Seq_HELA_Human1.42382475
39* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42023877
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41153523
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40771913
42* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39709334
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39337211
44PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37206511
45ZNF263_19887448_ChIP-Seq_K562_Human1.33838393
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.33801807
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33258518
48AHR_22903824_ChIP-Seq_MCF-7_Human1.32711655
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32358739
50FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31714839
51KDM5A_27292631_Chip-Seq_BREAST_Human1.30758959
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30579022
53TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29679089
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29569730
55SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.29343334
56VDR_22108803_ChIP-Seq_LS180_Human1.28623107
57FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25924086
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24132504
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23726118
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23689229
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21751159
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19573400
63* TCF4_18268006_ChIP-ChIP_LS174T_Human1.18831927
64FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.17973181
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17656831
66TCF7_22412390_ChIP-Seq_EML_Mouse1.17113404
67CLOCK_20551151_ChIP-Seq_293T_Human1.16777660
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.16574306
69* CREB1_26743006_Chip-Seq_LNCaP_Human1.16016593
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.15684400
71CDX2_22108803_ChIP-Seq_LS180_Human1.14603580
72LXR_22292898_ChIP-Seq_THP-1_Human1.14496591
73* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13522383
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13499678
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13456419
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12865763
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12623517
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11819146
79* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11032206
80ZNF274_21170338_ChIP-Seq_K562_Hela1.10131349
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.09305310
82* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08689950
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06799871
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06799871
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05918796
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05857789
87RXR_22108803_ChIP-Seq_LS180_Human1.05747294
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05228843
89GATA3_24758297_ChIP-Seq_MCF-7_Human1.05014567
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04888973
91* TBX20_22080862_ChIP-Seq_HEART_Mouse1.04851452
92* TBX20_22328084_ChIP-Seq_HEART_Mouse1.04851452
93ATF3_27146783_Chip-Seq_COLON_Human1.02823401
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.01506352
95BCAT_22108803_ChIP-Seq_LS180_Human1.00909684
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00426833
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99832992
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99832992
99* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98325098
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97967721
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97375415
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97228412
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97144128
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95299408
105TET1_21451524_ChIP-Seq_MESCs_Mouse0.94650050
106* GATA2_19941826_ChIP-Seq_K562_Human0.93446146
107* EZH2_27294783_Chip-Seq_ESCs_Mouse0.93242115
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93186475
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92066708
110SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91992525
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91722386
112* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91407834
113EP300_21415370_ChIP-Seq_HL-1_Mouse0.91181597
114* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91165549
115HNF4A_19822575_ChIP-Seq_HepG2_Human0.91074729
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90815756
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90562896
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90457204
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90279736
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89565289
121* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89537661
122* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88276511
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87836104
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.87776322
125* FOXA1_25552417_ChIP-Seq_VCAP_Human0.87182003
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84712052
127TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84684851
128TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83904134
129* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83824926
130* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83824926
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83340715
132TP53_16413492_ChIP-PET_HCT116_Human0.83262363
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82471287
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82460980
135TP63_23658742_ChIP-Seq_EP156T_Human0.81895576
136* KDM2B_26808549_Chip-Seq_K562_Human0.81226391
137SMC4_20622854_ChIP-Seq_HELA_Human0.78877999
138ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78150708
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77367924
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76314432
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75800721
142* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73717702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.24033121
2MP0002822_catalepsy4.55248743
3MP0005360_urolithiasis3.93690250
4MP0001666_abnormal_nutrient_absorption3.90965590
5MP0003878_abnormal_ear_physiology3.51395157
6MP0005377_hearing/vestibular/ear_phenot3.51395157
7MP0004264_abnormal_extraembryonic_tissu3.23957142
8MP0005451_abnormal_body_composition3.21051728
9MP0003866_abnormal_defecation2.87712911
10MP0004233_abnormal_muscle_weight2.86422060
11MP0004043_abnormal_pH_regulation2.69652878
12MP0000462_abnormal_digestive_system2.68860370
13MP0001765_abnormal_ion_homeostasis2.60128697
14MP0005310_abnormal_salivary_gland2.40769467
15MP0008875_abnormal_xenobiotic_pharmacok2.30766631
16MP0003283_abnormal_digestive_organ2.26133366
17MP0003300_gastrointestinal_ulcer2.14201097
18MP0010386_abnormal_urinary_bladder2.08393818
19MP0005167_abnormal_blood-brain_barrier2.08231034
20* MP0001663_abnormal_digestive_system2.06560660
21MP0005085_abnormal_gallbladder_physiolo2.06010298
22* MP0005381_digestive/alimentary_phenotyp2.05611954
23* MP0001664_abnormal_digestion1.89645827
24MP0000627_abnormal_mammary_gland1.83746894
25MP0000538_abnormal_urinary_bladder1.83189033
26MP0010155_abnormal_intestine_physiology1.82816723
27MP0000537_abnormal_urethra_morphology1.81594190
28MP0005076_abnormal_cell_differentiation1.80899311
29MP0010352_gastrointestinal_tract_polyps1.76740952
30MP0009780_abnormal_chondrocyte_physiolo1.75649197
31MP0003252_abnormal_bile_duct1.74045524
32MP0008004_abnormal_stomach_pH1.73381579
33MP0002139_abnormal_hepatobiliary_system1.73194424
34* MP0001873_stomach_inflammation1.70929178
35MP0004782_abnormal_surfactant_physiolog1.69744607
36MP0004019_abnormal_vitamin_homeostasis1.65550990
37MP0010678_abnormal_skin_adnexa1.62814802
38MP0009643_abnormal_urine_homeostasis1.61774130
39MP0003183_abnormal_peptide_metabolism1.59566341
40MP0005636_abnormal_mineral_homeostasis1.59427184
41MP0000383_abnormal_hair_follicle1.57708475
42MP0002796_impaired_skin_barrier1.56077604
43MP0000477_abnormal_intestine_morphology1.53545307
44MP0004858_abnormal_nervous_system1.52394051
45MP0000377_abnormal_hair_follicle1.51753744
46MP0001727_abnormal_embryo_implantation1.49862526
47MP0005083_abnormal_biliary_tract1.49314722
48MP0001881_abnormal_mammary_gland1.49116802
49MP0005248_abnormal_Harderian_gland1.48764427
50MP0005409_darkened_coat_color1.41156927
51MP0003693_abnormal_embryo_hatching1.39219340
52MP0002166_altered_tumor_susceptibility1.36616357
53MP0005257_abnormal_intraocular_pressure1.35826529
54MP0000751_myopathy1.35791552
55MP0003646_muscle_fatigue1.28512521
56MP0000427_abnormal_hair_cycle1.28429468
57MP0000490_abnormal_crypts_of1.27727695
58MP0003868_abnormal_feces_composition1.27300473
59MP0003705_abnormal_hypodermis_morpholog1.26773952
60MP0001756_abnormal_urination1.24260823
61MP0000579_abnormal_nail_morphology1.21910234
62MP0004087_abnormal_muscle_fiber1.19285235
63MP0004147_increased_porphyrin_level1.15437931
64MP0002876_abnormal_thyroid_physiology1.15117544
65MP0001919_abnormal_reproductive_system1.14189373
66MP0000566_synostosis1.12067037
67MP0003191_abnormal_cellular_cholesterol1.10226362
68MP0000747_muscle_weakness1.07697549
69MP0010329_abnormal_lipoprotein_level1.07289273
70MP0005670_abnormal_white_adipose1.06746119
71MP0005058_abnormal_lysosome_morphology1.06401402
72MP0004484_altered_response_of1.06064788
73MP0000678_abnormal_parathyroid_gland1.05970683
74MP0002269_muscular_atrophy1.05094303
75MP0005408_hypopigmentation1.04010109
76MP0006054_spinal_hemorrhage1.03706361
77MP0005365_abnormal_bile_salt1.03539582
78MP0004270_analgesia1.03246266
79MP0004885_abnormal_endolymph1.02983250
80MP0005166_decreased_susceptibility_to1.01226274
81MP0002009_preneoplasia1.00881775
82MP0002254_reproductive_system_inflammat1.00206423
83MP0004947_skin_inflammation1.00024917
84MP0002136_abnormal_kidney_physiology0.97446201
85MP0005332_abnormal_amino_acid0.96230650
86MP0009672_abnormal_birth_weight0.96205670
87MP0003936_abnormal_reproductive_system0.95508226
88MP0009384_cardiac_valve_regurgitation0.95456284
89MP0002909_abnormal_adrenal_gland0.94604564
90MP0000613_abnormal_salivary_gland0.93200728
91MP0002877_abnormal_melanocyte_morpholog0.92514982
92MP0000750_abnormal_muscle_regeneration0.91573014
93MP0002006_tumorigenesis0.90330343
94MP0000759_abnormal_skeletal_muscle0.89512599
95MP0000733_abnormal_muscle_development0.89484593
96MP0003315_abnormal_perineum_morphology0.88909327
97MP0003045_fibrosis0.88595066
98MP0004185_abnormal_adipocyte_glucose0.88548702
99MP0003879_abnormal_hair_cell0.88128563
100MP0005647_abnormal_sex_gland0.86394494
101MP0003941_abnormal_skin_development0.86046620
102MP0002108_abnormal_muscle_morphology0.84953287
103MP0002837_dystrophic_cardiac_calcinosis0.84842491
104MP0004130_abnormal_muscle_cell0.84339807
105MP0002098_abnormal_vibrissa_morphology0.80611694
106MP0005375_adipose_tissue_phenotype0.80288161
107MP0008872_abnormal_physiological_respon0.80278363
108MP0001485_abnormal_pinna_reflex0.79989007
109MP0002249_abnormal_larynx_morphology0.79626649
110MP0010630_abnormal_cardiac_muscle0.77869767
111MP0001849_ear_inflammation0.76519118
112MP0005330_cardiomyopathy0.76503507
113MP0000534_abnormal_ureter_morphology0.76113180
114MP0004145_abnormal_muscle_electrophysio0.75469093
115MP0005319_abnormal_enzyme/_coenzyme0.74483607
116MP0000749_muscle_degeneration0.72457287
117MP0005501_abnormal_skin_physiology0.71191119
118MP0000230_abnormal_systemic_arterial0.71065780
119* MP0000470_abnormal_stomach_morphology0.70950232
120MP0000467_abnormal_esophagus_morphology0.70201436
121MP0002106_abnormal_muscle_physiology0.68916915
122MP0010771_integument_phenotype0.68428304
123MP0005369_muscle_phenotype0.68057665
124MP0002896_abnormal_bone_mineralization0.67091653
125MP0003123_paternal_imprinting0.66931791
126MP0009379_abnormal_foot_pigmentation0.66625643
127MP0003453_abnormal_keratinocyte_physiol0.66506636
128MP0009931_abnormal_skin_appearance0.66194522
129MP0002118_abnormal_lipid_homeostasis0.64970262
130MP0002234_abnormal_pharynx_morphology0.63167953
131MP0001346_abnormal_lacrimal_gland0.62881238
132MP0002138_abnormal_hepatobiliary_system0.61721456
133MP0002089_abnormal_postnatal_growth/wei0.61288086
134MP0005367_renal/urinary_system_phenotyp0.59964472
135MP0000516_abnormal_urinary_system0.59964472
136MP0005165_increased_susceptibility_to0.59396376
137MP0004036_abnormal_muscle_relaxation0.58970085
138MP0000013_abnormal_adipose_tissue0.58729688
139MP0001216_abnormal_epidermal_layer0.58370009
140MP0005187_abnormal_penis_morphology0.57021155
141MP0005666_abnormal_adipose_tissue0.56805839
142MP0000762_abnormal_tongue_morphology0.56065122

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.16885542
2Malnutrition (HP:0004395)5.75359238
3Hyperactive renin-angiotensin system (HP:0000841)5.34864626
4Ileus (HP:0002595)4.91945967
5Metabolic alkalosis (HP:0200114)4.50350265
6Abnormality of chloride homeostasis (HP:0011422)4.36342478
7Flat acetabular roof (HP:0003180)3.91714973
8Abdominal distention (HP:0003270)3.83839380
9Sparse lateral eyebrow (HP:0005338)3.82117583
10Myopathic facies (HP:0002058)3.71099748
11Abnormality of small intestinal villus morphology (HP:0011472)3.55405219
12Villous atrophy (HP:0011473)3.55405219
13Hyperkalemia (HP:0002153)3.44101781
14Curly hair (HP:0002212)3.37076055
15Septate vagina (HP:0001153)3.31184630
16Symphalangism affecting the phalanges of the hand (HP:0009773)3.30592482
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.22861154
18Flattened epiphyses (HP:0003071)3.19563005
19Abnormality of renin-angiotensin system (HP:0000847)3.09167312
20Mildly elevated creatine phosphokinase (HP:0008180)3.07317875
21Flat capital femoral epiphysis (HP:0003370)3.05654140
22Spinal cord compression (HP:0002176)3.04524680
23Concave nail (HP:0001598)3.02917200
24Dehydration (HP:0001944)3.02432023
25Vacuolated lymphocytes (HP:0001922)2.99335563
26Fat malabsorption (HP:0002630)2.95405589
27Distal lower limb muscle weakness (HP:0009053)2.92340815
28Hyponatremia (HP:0002902)2.90644523
29Germ cell neoplasia (HP:0100728)2.89134915
30Abnormality of the 2nd finger (HP:0004100)2.85061507
31Abnormality of proline metabolism (HP:0010907)2.83541470
32Hydroxyprolinuria (HP:0003080)2.83541470
33Prostate neoplasm (HP:0100787)2.81547179
34Thin bony cortex (HP:0002753)2.80294044
35Chronic diarrhea (HP:0002028)2.77206955
36Cupped ribs (HP:0000887)2.76143053
37Muscle fiber inclusion bodies (HP:0100299)2.74954825
38Abnormality of the 1st metacarpal (HP:0010009)2.73032887
39Distal arthrogryposis (HP:0005684)2.72519304
40Abnormal tarsal ossification (HP:0008369)2.68655524
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.67186033
42Termporal pattern (HP:0011008)2.66870730
43Insidious onset (HP:0003587)2.66870730
44Widely patent fontanelles and sutures (HP:0004492)2.64448437
45Type 1 muscle fiber predominance (HP:0003803)2.63442077
46Absent phalangeal crease (HP:0006109)2.61241317
47Hyperaldosteronism (HP:0000859)2.60228216
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.59680992
49Amelogenesis imperfecta (HP:0000705)2.54525284
50Short hallux (HP:0010109)2.54060738
51Bulbar palsy (HP:0001283)2.52068396
52Breech presentation (HP:0001623)2.50646203
53Congenital sensorineural hearing impairment (HP:0008527)2.48345712
54Asymmetry of the thorax (HP:0001555)2.48137539
55Woolly hair (HP:0002224)2.47289981
56Palpitations (HP:0001962)2.46957174
57Intrahepatic cholestasis (HP:0001406)2.46688313
58Hypokalemia (HP:0002900)2.45824447
59J-shaped sella turcica (HP:0002680)2.45171785
60Exercise-induced myalgia (HP:0003738)2.43302647
61Nemaline bodies (HP:0003798)2.43179497
62Syncope (HP:0001279)2.42980554
63Rectal prolapse (HP:0002035)2.40234250
64Milia (HP:0001056)2.39424705
65Visceral angiomatosis (HP:0100761)2.37373842
66Rhabdomyolysis (HP:0003201)2.36803954
67Abnormality of the middle phalanges of the toes (HP:0010183)2.35697810
68Ventricular tachycardia (HP:0004756)2.35242368
69Exocrine pancreatic insufficiency (HP:0001738)2.33384005
70Abnormality of the phalanges of the hallux (HP:0010057)2.32994616
71Hyperparathyroidism (HP:0000843)2.32391093
72Lip pit (HP:0100267)2.31091954
73Abnormality of the distal phalanges of the toes (HP:0010182)2.31064234
74Aplasia/Hypoplasia of the hallux (HP:0008362)2.30949537
75Abnormal cartilage morphology (HP:0002763)2.30368229
76Distal lower limb amyotrophy (HP:0008944)2.29979404
77Abnormality of the proximal phalanges of the hand (HP:0009834)2.29874773
78Breast carcinoma (HP:0003002)2.29101578
79Bundle branch block (HP:0011710)2.27621024
80Abnormal hair laboratory examination (HP:0003328)2.26639551
81Potter facies (HP:0002009)2.23815079
82Facial shape deformation (HP:0011334)2.23815079
83Abnormality of purine metabolism (HP:0004352)2.23796728
84Gastrointestinal dysmotility (HP:0002579)2.22039303
85Short 1st metacarpal (HP:0010034)2.20694719
86Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.20694719
87Limb-girdle muscle atrophy (HP:0003797)2.20101166
88Abnormality of potassium homeostasis (HP:0011042)2.19792726
89Aortic aneurysm (HP:0004942)2.18186251
90Hemangiomatosis (HP:0007461)2.17845145
91Proximal tubulopathy (HP:0000114)2.17508349
92Abnormal foot bone ossification (HP:0010675)2.16900440
93Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.16672053
94Biliary tract neoplasm (HP:0100574)2.15922196
95Abnormality of magnesium homeostasis (HP:0004921)2.15880441
96Pili torti (HP:0003777)2.15545550
97Hyperuricemia (HP:0002149)2.12163566
98Increased purine levels (HP:0004368)2.12163566
99Abnormality of cochlea (HP:0000375)2.11903252
100Hyperammonemia (HP:0001987)2.11572904
101Increased circulating renin level (HP:0000848)2.10549303
102Decreased circulating renin level (HP:0003351)2.09322840
103Steatorrhea (HP:0002570)2.08555307
104Vertebral hypoplasia (HP:0008417)2.08334223
105Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.08334223
106Hyperglycinuria (HP:0003108)2.07664314
107Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07332786
108Ulnar deviation of finger (HP:0009465)2.06849550
109Hypomagnesemia (HP:0002917)2.06723214
110Microretrognathia (HP:0000308)2.06448115
111Abnormal finger flexion creases (HP:0006143)2.05632942
112Protuberant abdomen (HP:0001538)2.05203641
113Conjugated hyperbilirubinemia (HP:0002908)2.03180783
114Hyperphosphatemia (HP:0002905)2.03071281
115Oligomenorrhea (HP:0000876)2.03003911
116Neck muscle weakness (HP:0000467)2.02878144
117Hypoplasia of the uterus (HP:0000013)2.02797683
118Abnormality of the calf musculature (HP:0001430)2.02017679
119Ureteral stenosis (HP:0000071)2.00681534
120EMG: myopathic abnormalities (HP:0003458)2.00578852
121Ulnar deviation of the wrist (HP:0003049)1.99580717
122Fragile nails (HP:0001808)1.98633235
123Alkalosis (HP:0001948)1.98611884
124Hyporeflexia of lower limbs (HP:0002600)1.97998156
125Severe short stature (HP:0003510)1.97250757
126Broad face (HP:0000283)1.97176898
127Short phalanx of the thumb (HP:0009660)1.96394608
128Microglossia (HP:0000171)1.95727840
129Ventricular fibrillation (HP:0001663)1.95588386
130Abnormality of the gastric mucosa (HP:0004295)1.94603321
131Muscle hypertrophy of the lower extremities (HP:0008968)1.93344179
132Exercise-induced muscle cramps (HP:0003710)1.93281895
133Abnormality of sodium homeostasis (HP:0010931)1.92504773
134Sensorimotor neuropathy (HP:0007141)1.92410996
135Rimmed vacuoles (HP:0003805)1.91894924
136Calf muscle hypertrophy (HP:0008981)1.90633888
137Abnormality of carpal bone ossification (HP:0006257)1.90154390
138Pustule (HP:0200039)1.89894749
139Dysmetric saccades (HP:0000641)1.89533809
140Gout (HP:0001997)1.88997646
141Increased connective tissue (HP:0009025)1.88759667
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.88545240
143Cone-rod dystrophy (HP:0000548)1.86009432
144Atrophic scars (HP:0001075)1.84931872
145Ureteral obstruction (HP:0006000)1.83695729
146Micronodular cirrhosis (HP:0001413)1.83510926
147Difficulty running (HP:0009046)1.82651640
148Myoglobinuria (HP:0002913)1.82633792
149Plantar hyperkeratosis (HP:0007556)1.82337354
150Abnormality of nail color (HP:0100643)1.80906476
151Abnormal hand bone ossification (HP:0010660)1.80460237
152Testicular atrophy (HP:0000029)1.77653315
153Renal tubular acidosis (HP:0001947)1.77156759
154Advanced eruption of teeth (HP:0006288)1.75348703
155Abnormal ossification of hand bones (HP:0005921)1.73921188
156Abnormal vertebral ossification (HP:0100569)1.73416659
157Adrenal overactivity (HP:0002717)1.67139116
158Congenital glaucoma (HP:0001087)1.64638630
159Testicular neoplasm (HP:0010788)1.63619717
160Exostoses (HP:0100777)1.63533536
161Vertebral clefting (HP:0008428)1.63353678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.72988510
2PIK3CA4.80630711
3FRK4.05223668
4LMTK23.86772927
5MST43.68937775
6MAP3K23.57724340
7NME13.22450005
8KSR23.03215470
9AKT32.62071078
10STK392.45848145
11MET2.32774565
12MYLK2.28897187
13SIK12.28004252
14CAMK1D2.18214464
15MAP2K22.14190846
16SMG12.08188710
17OXSR11.95564832
18EIF2AK11.81011568
19TTN1.74196564
20TAOK31.71806358
21CAMK1G1.59611728
22RIPK41.55343518
23ICK1.45621594
24CDK121.43053981
25DMPK1.41051201
26NEK61.38744994
27PRKG21.35283755
28TESK11.34511544
29MAP2K11.32499805
30PIK3CG1.30662000
31WNK41.29851353
32GRK61.27469420
33MUSK1.25533779
34ERN11.21993753
35EEF2K1.21650657
36LATS11.16848893
37PDK21.16354934
38PRKD31.16275652
39FER1.15047371
40IRAK31.14581029
41PTK61.10788354
42EPHB21.07816817
43OBSCN1.07441747
44NEK11.07419017
45RIPK11.01772408
46MAP3K70.97517403
47CAMK2D0.92095977
48MTOR0.89061165
49MAP3K10.86728457
50TNK20.85426887
51MAP3K120.85044538
52NUAK10.83144442
53EPHA40.82314573
54CDK70.81503561
55ILK0.80191558
56PHKG20.78915222
57PHKG10.78915222
58MAPKAPK30.78539263
59DDR20.76188367
60ACVR1B0.74772071
61FGFR40.72998464
62MAP3K90.70893344
63TAOK10.70169320
64EPHA20.70155165
65RPS6KB10.70123706
66MAP3K80.69995423
67SCYL20.69256434
68RPS6KA20.66568007
69PTK20.66459121
70TAF10.66301687
71PDK30.65934015
72PDK40.65934015
73PDPK10.62529584
74PBK0.61860078
75LRRK20.61448776
76LATS20.57480004
77PRKCI0.56226211
78RET0.56008143
79AKT20.52169661
80PTK2B0.50825611
81NME20.49998558
82BCKDK0.49942677
83CHUK0.49233339
84STK100.46667941
85TSSK60.45024234
86CAMK2G0.44669965
87WNK10.44233984
88ROCK10.44214605
89PDK10.43046545
90EIF2AK30.42775234
91CAMK2B0.42628659
92EPHB10.41647093
93TRIB30.40784387
94PRKD20.40099051
95LIMK10.37382832
96PRKAA20.36900177
97RPS6KB20.36463095
98MATK0.36458363
99PAK20.36162431
100ERBB20.35458786
101ROCK20.34848747
102YES10.34071102
103CDK90.33539568
104TRPM70.32949849
105NTRK30.32927067
106ERBB40.30778695
107PRKAA10.30772633
108MAP2K60.30641785
109PKN20.30351382
110MAP3K30.29359506
111MAPKAPK20.28723484
112PDGFRA0.28644140
113SGK30.28540256
114MAP2K40.27917101
115FYN0.26287036
116SIK30.25917826
117PAK30.25781877
118MAP3K100.25472478
119PRKCA0.24790087
120KSR10.24603371
121PRKCQ0.24468357
122TESK20.24422197
123RPS6KC10.24252671
124RPS6KL10.24252671
125TTK0.23553430
126BMX0.23311860
127STK38L0.22887360
128ERBB30.21641002
129CDC42BPA0.21055819
130CSNK1E0.20931308
131BRSK20.20724041
132SRC0.20544611
133TBK10.20422073
134MAPK110.20185519
135JAK20.19593839
136FGR0.19458284
137CAMK2A0.19369906
138PAK40.19213185
139MARK20.19109227
140CAMKK10.17237035
141MAP3K40.15547625
142ARAF0.14339445

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.44044909
2Mineral absorption_Homo sapiens_hsa049784.27395716
3Nitrogen metabolism_Homo sapiens_hsa009102.98806947
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.87528731
5Renin-angiotensin system_Homo sapiens_hsa046142.74607767
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.58773674
7Fat digestion and absorption_Homo sapiens_hsa049752.50664281
8Bile secretion_Homo sapiens_hsa049762.27551289
9Fatty acid biosynthesis_Homo sapiens_hsa000612.13869876
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02652078
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83478084
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.71307549
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65800844
14Fatty acid metabolism_Homo sapiens_hsa012121.63841062
15Protein digestion and absorption_Homo sapiens_hsa049741.60888901
16Salivary secretion_Homo sapiens_hsa049701.52330722
17Starch and sucrose metabolism_Homo sapiens_hsa005001.52143030
18Vitamin digestion and absorption_Homo sapiens_hsa049771.50207607
19Gastric acid secretion_Homo sapiens_hsa049711.49332746
20Fructose and mannose metabolism_Homo sapiens_hsa000511.48865783
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47222255
22Galactose metabolism_Homo sapiens_hsa000521.47062759
23AMPK signaling pathway_Homo sapiens_hsa041521.46879084
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40903649
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39969101
26Insulin signaling pathway_Homo sapiens_hsa049101.39846834
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36787220
28Phenylalanine metabolism_Homo sapiens_hsa003601.30216638
29Histidine metabolism_Homo sapiens_hsa003401.25422532
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23088358
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22756367
32Pancreatic secretion_Homo sapiens_hsa049721.22537377
33Tight junction_Homo sapiens_hsa045301.20212613
34Glycerolipid metabolism_Homo sapiens_hsa005611.14829954
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11723031
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.07803406
37Glucagon signaling pathway_Homo sapiens_hsa049221.04725238
38Thyroid hormone synthesis_Homo sapiens_hsa049181.04694484
39Fatty acid degradation_Homo sapiens_hsa000711.03670595
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01670560
41Vibrio cholerae infection_Homo sapiens_hsa051101.00746912
42Pentose phosphate pathway_Homo sapiens_hsa000300.99453429
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96129001
44Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94442531
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92674906
46Prostate cancer_Homo sapiens_hsa052150.89960145
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88937939
48ErbB signaling pathway_Homo sapiens_hsa040120.86741772
49Biosynthesis of amino acids_Homo sapiens_hsa012300.86647780
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.86641635
51PPAR signaling pathway_Homo sapiens_hsa033200.86546113
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85082268
53Thyroid cancer_Homo sapiens_hsa052160.82722167
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.82353256
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81119441
56Other glycan degradation_Homo sapiens_hsa005110.80760248
57Renal cell carcinoma_Homo sapiens_hsa052110.79594762
58mTOR signaling pathway_Homo sapiens_hsa041500.78565926
59Propanoate metabolism_Homo sapiens_hsa006400.78326323
60Tryptophan metabolism_Homo sapiens_hsa003800.77189686
61Non-small cell lung cancer_Homo sapiens_hsa052230.76899411
62Bladder cancer_Homo sapiens_hsa052190.74992815
63Butanoate metabolism_Homo sapiens_hsa006500.74765151
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73895251
65Acute myeloid leukemia_Homo sapiens_hsa052210.73778845
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73722433
67Prolactin signaling pathway_Homo sapiens_hsa049170.73459063
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.72791363
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72602197
70Pyruvate metabolism_Homo sapiens_hsa006200.71296264
71Glutathione metabolism_Homo sapiens_hsa004800.71244740
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71144321
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70864875
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.70750583
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.70527665
76Caffeine metabolism_Homo sapiens_hsa002320.70168606
77Sphingolipid metabolism_Homo sapiens_hsa006000.69700457
78ABC transporters_Homo sapiens_hsa020100.68179520
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67978616
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.66961323
81Renin secretion_Homo sapiens_hsa049240.66815499
82Adherens junction_Homo sapiens_hsa045200.64678805
83Lysine degradation_Homo sapiens_hsa003100.64503758
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63798975
85Sulfur relay system_Homo sapiens_hsa041220.63698389
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.63486806
87Cardiac muscle contraction_Homo sapiens_hsa042600.62655697
88Long-term potentiation_Homo sapiens_hsa047200.62602176
89Chronic myeloid leukemia_Homo sapiens_hsa052200.61896546
90Alzheimers disease_Homo sapiens_hsa050100.61551844
91Choline metabolism in cancer_Homo sapiens_hsa052310.61362958
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60775466
93Arginine and proline metabolism_Homo sapiens_hsa003300.60283558
94Fatty acid elongation_Homo sapiens_hsa000620.59414487
95Tyrosine metabolism_Homo sapiens_hsa003500.56961318
96Collecting duct acid secretion_Homo sapiens_hsa049660.56813108
97GnRH signaling pathway_Homo sapiens_hsa049120.55663431
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54815750
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54443990
100Inositol phosphate metabolism_Homo sapiens_hsa005620.54103132
101Type II diabetes mellitus_Homo sapiens_hsa049300.52263864
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49198460
103Hepatitis C_Homo sapiens_hsa051600.47891036
104Oxidative phosphorylation_Homo sapiens_hsa001900.47564176
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.46818951
106Oxytocin signaling pathway_Homo sapiens_hsa049210.46120341
107Insulin secretion_Homo sapiens_hsa049110.45999921
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44174253
109Pancreatic cancer_Homo sapiens_hsa052120.43936214
110Carbon metabolism_Homo sapiens_hsa012000.43792212
111Arginine biosynthesis_Homo sapiens_hsa002200.43626955
112Salmonella infection_Homo sapiens_hsa051320.42961655
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42690349
114Amphetamine addiction_Homo sapiens_hsa050310.42674221
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42263751
116Folate biosynthesis_Homo sapiens_hsa007900.41959160
117Gap junction_Homo sapiens_hsa045400.41831618
118N-Glycan biosynthesis_Homo sapiens_hsa005100.41188657
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39517116
120VEGF signaling pathway_Homo sapiens_hsa043700.38742460
121beta-Alanine metabolism_Homo sapiens_hsa004100.38363865
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37483871
123Calcium signaling pathway_Homo sapiens_hsa040200.35726704
124HIF-1 signaling pathway_Homo sapiens_hsa040660.35007069
125Insulin resistance_Homo sapiens_hsa049310.34651190
126Long-term depression_Homo sapiens_hsa047300.34637461
127Glioma_Homo sapiens_hsa052140.34276031
128Dorso-ventral axis formation_Homo sapiens_hsa043200.34168822
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34078171
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32391044
131Amoebiasis_Homo sapiens_hsa051460.31821299
132Circadian entrainment_Homo sapiens_hsa047130.31264756
133Chemical carcinogenesis_Homo sapiens_hsa052040.30923318
134Endometrial cancer_Homo sapiens_hsa052130.28633882
135Dilated cardiomyopathy_Homo sapiens_hsa054140.27734861
136Estrogen signaling pathway_Homo sapiens_hsa049150.27377027

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