SLC9A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.93988153
2intestinal cholesterol absorption (GO:0030299)8.47193975
3angiotensin maturation (GO:0002003)7.77822806
4drug catabolic process (GO:0042737)6.66183875
5drug transmembrane transport (GO:0006855)5.97284935
6actin filament depolymerization (GO:0030042)5.88887000
7drug transport (GO:0015893)5.73055775
8regulation of guanylate cyclase activity (GO:0031282)5.71657741
9flavonoid metabolic process (GO:0009812)5.64751404
10vitamin A metabolic process (GO:0006776)5.44617690
11modified amino acid transport (GO:0072337)5.36705282
12regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.32011989
13sulfate transmembrane transport (GO:1902358)5.08681569
14UDP-N-acetylglucosamine metabolic process (GO:0006047)4.88197574
15virion attachment to host cell (GO:0019062)4.88093647
16adhesion of symbiont to host cell (GO:0044650)4.88093647
17renal system process involved in regulation of blood volume (GO:0001977)4.87504843
18epoxygenase P450 pathway (GO:0019373)4.83012455
19exogenous drug catabolic process (GO:0042738)4.82372625
203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.80814963
21purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.80814963
22uronic acid metabolic process (GO:0006063)4.79438126
23glucuronate metabolic process (GO:0019585)4.79438126
24digestive system process (GO:0022600)4.71951437
25urate metabolic process (GO:0046415)4.71088933
26fat-soluble vitamin biosynthetic process (GO:0042362)4.59667223
27bicarbonate transport (GO:0015701)4.37781092
28positive regulation of pseudopodium assembly (GO:0031274)4.37694555
29sulfur compound transport (GO:0072348)4.34750300
30receptor guanylyl cyclase signaling pathway (GO:0007168)4.34459840
31oligosaccharide catabolic process (GO:0009313)4.31804534
32maintenance of gastrointestinal epithelium (GO:0030277)4.26125191
33polyol transport (GO:0015791)4.25039949
34renal absorption (GO:0070293)4.23289433
35glomerular filtration (GO:0003094)4.19448194
36regulation of bile acid biosynthetic process (GO:0070857)4.17563409
37lysine metabolic process (GO:0006553)4.13785448
38lysine catabolic process (GO:0006554)4.13785448
39regulation of systemic arterial blood pressure (GO:0003073)4.12360340
40sulfate transport (GO:0008272)4.08955341
41peptide catabolic process (GO:0043171)4.04545091
42hormone catabolic process (GO:0042447)4.00462692
43urea cycle (GO:0000050)3.96442431
44renal filtration (GO:0097205)3.96354537
45bundle of His cell to Purkinje myocyte communication (GO:0086069)3.90988112
46adhesion of symbiont to host (GO:0044406)3.90915234
47O-glycan processing (GO:0016266)3.87457090
48regulation of pseudopodium assembly (GO:0031272)3.86738500
49phosphate ion transport (GO:0006817)3.84955886
50transepithelial transport (GO:0070633)3.83426908
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.83192085
52digestion (GO:0007586)3.81777741
53excretion (GO:0007588)3.81634227
54negative regulation of cholesterol transport (GO:0032375)3.80633598
55negative regulation of sterol transport (GO:0032372)3.80633598
56positive regulation of respiratory burst (GO:0060267)3.77208356
57positive regulation of fatty acid beta-oxidation (GO:0032000)3.77090877
58bile acid and bile salt transport (GO:0015721)3.76971688
59organic cation transport (GO:0015695)3.76858331
60ethanol oxidation (GO:0006069)3.76635852
61cellular response to hepatocyte growth factor stimulus (GO:0035729)3.76033386
62response to hepatocyte growth factor (GO:0035728)3.76033386
63glucose 6-phosphate metabolic process (GO:0051156)3.74132772
64NADH metabolic process (GO:0006734)3.73221043
65regulation of vitamin metabolic process (GO:0030656)3.73100059
66urea metabolic process (GO:0019627)3.71410745
67positive regulation of guanylate cyclase activity (GO:0031284)3.71373507
68phospholipid efflux (GO:0033700)3.71299258
69regulation of cellular extravasation (GO:0002691)3.69753306
70positive regulation of lipoprotein lipase activity (GO:0051006)3.68619126
71positive regulation of triglyceride lipase activity (GO:0061365)3.68619126
72regulation of cholesterol homeostasis (GO:2000188)3.68033110
73regulation of triglyceride catabolic process (GO:0010896)3.62373196
74desmosome organization (GO:0002934)3.58471912
75plasma lipoprotein particle assembly (GO:0034377)3.58418857
76lipoprotein metabolic process (GO:0042157)3.56457653
77homocysteine metabolic process (GO:0050667)3.52827385
78protein-lipid complex assembly (GO:0065005)3.51988010
79diacylglycerol metabolic process (GO:0046339)3.51568869
80glucocorticoid biosynthetic process (GO:0006704)3.50917060
81sulfation (GO:0051923)3.49749105
82negative regulation of digestive system process (GO:0060457)3.49104973
83renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.48343430
84regulation of cholesterol esterification (GO:0010872)3.46481899
85vitamin transmembrane transport (GO:0035461)3.45942342
86phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.45294929
87phosphate ion transmembrane transport (GO:0035435)3.43898476
88epithelial cell-cell adhesion (GO:0090136)3.40534296
89lipoprotein transport (GO:0042953)3.38996118
90regulation of cGMP biosynthetic process (GO:0030826)3.38909956
91quaternary ammonium group transport (GO:0015697)3.38691403
92cGMP-mediated signaling (GO:0019934)3.38208819
93cellular carbohydrate catabolic process (GO:0044275)3.36229045
94nitrogen cycle metabolic process (GO:0071941)3.35568843
95intestinal epithelial cell development (GO:0060576)3.33987783
96sterol homeostasis (GO:0055092)3.33626938
97drug metabolic process (GO:0017144)3.33025622
98glycosphingolipid catabolic process (GO:0046479)3.30227506
99cysteine metabolic process (GO:0006534)3.30051103
100cholesterol homeostasis (GO:0042632)3.29319298
101response to phenylpropanoid (GO:0080184)3.29064063
102aminoglycoside antibiotic metabolic process (GO:0030647)3.25655836
103cholesterol efflux (GO:0033344)3.21817115
104vitamin D metabolic process (GO:0042359)3.20489901
105nonribosomal peptide biosynthetic process (GO:0019184)3.19774380
106fructose metabolic process (GO:0006000)3.19614566
107epithelial structure maintenance (GO:0010669)3.18231909
108transcytosis (GO:0045056)3.17889387
109purine nucleotide salvage (GO:0032261)3.17732742
110glutathione biosynthetic process (GO:0006750)3.17576169
111glycolipid catabolic process (GO:0019377)3.17358857
112positive regulation of Cdc42 GTPase activity (GO:0043089)3.17112964
113nucleoside diphosphate biosynthetic process (GO:0009133)3.15762979
114phosphate ion homeostasis (GO:0055062)3.15611385
115trivalent inorganic anion homeostasis (GO:0072506)3.15611385
116antibacterial humoral response (GO:0019731)3.15420152
117negative regulation of myotube differentiation (GO:0010832)3.14806693
118positive regulation of lipid catabolic process (GO:0050996)3.13257918
119sodium ion homeostasis (GO:0055078)3.12967250
120carnitine transport (GO:0015879)3.12154498
121amino-acid betaine transport (GO:0015838)3.12154498
122antimicrobial humoral response (GO:0019730)3.11692780
123regulation of respiratory burst (GO:0060263)3.11482173
124sperm capacitation (GO:0048240)3.11418408
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.10559775
126fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.10314581
127antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07040106
128very-low-density lipoprotein particle assembly (GO:0034379)3.06671225
129membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.04868863
130cellular response to reactive nitrogen species (GO:1902170)3.03895034
131regulation of digestive system process (GO:0044058)3.02927381
132oligosaccharide biosynthetic process (GO:0009312)3.01951850
133ethanol metabolic process (GO:0006067)3.00697375
134response to hydroperoxide (GO:0033194)3.00488001
135peptide hormone processing (GO:0016486)3.00009242
136cellular response to nitric oxide (GO:0071732)2.97729342
137sodium ion export (GO:0071436)2.96555137
138glutamine family amino acid biosynthetic process (GO:0009084)2.94594391
139antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91490349
140regulation of systemic arterial blood pressure by hormone (GO:0001990)2.90761655
141regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.90761655
142endocrine process (GO:0050886)2.90761655
143regulation of fatty acid beta-oxidation (GO:0031998)2.88880205
144vitamin transport (GO:0051180)2.88023453
145beta-amyloid metabolic process (GO:0050435)2.86267976
146sphingomyelin metabolic process (GO:0006684)2.86154973
147calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.84539759
148cellular glucuronidation (GO:0052695)2.83784005
149amino acid transmembrane transport (GO:0003333)2.82905502
150GDP-mannose metabolic process (GO:0019673)2.79226785
151thrombin receptor signaling pathway (GO:0070493)2.78327951
152proline biosynthetic process (GO:0006561)2.76387417
153auditory receptor cell differentiation (GO:0042491)2.76302293
154positive regulation of fatty acid oxidation (GO:0046321)2.71520060
155glycosylceramide metabolic process (GO:0006677)2.69414192
156regulation of cGMP metabolic process (GO:0030823)2.67147168
157citrulline metabolic process (GO:0000052)2.66605376
158antigen processing and presentation of endogenous antigen (GO:0019883)2.65457295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.51414485
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.55289579
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.24230443
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.22663200
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84552415
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.74995872
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.74355961
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.73618003
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.66380242
10* GATA4_25053715_ChIP-Seq_YYC3_Human2.64397893
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.50677258
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.46351697
13GATA6_25053715_ChIP-Seq_YYC3_Human2.37540476
14SOX2_20726797_ChIP-Seq_SW620_Human2.30478634
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.20205414
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.18417029
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.08766183
18VDR_21846776_ChIP-Seq_THP-1_Human1.95660614
19* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.93466124
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90438346
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.81239990
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76872645
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70573538
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.69966618
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65859089
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65539379
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64224918
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.63323472
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62945578
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.61596510
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58232956
32VDR_22108803_ChIP-Seq_LS180_Human1.55213444
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.53841776
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51782232
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.51648600
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48245612
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47788787
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.47435887
39TCF7_22412390_ChIP-Seq_EML_Mouse1.46423884
40CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.46145665
41KLF5_25053715_ChIP-Seq_YYC3_Human1.45181926
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.43741486
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.43504513
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42862382
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42508626
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42242566
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41982878
48VDR_24763502_ChIP-Seq_THP-1_Human1.39072441
49HNF4A_19822575_ChIP-Seq_HepG2_Human1.38634982
50KDM2B_26808549_Chip-Seq_K562_Human1.37481363
51RACK7_27058665_Chip-Seq_MCF-7_Human1.36709844
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35808831
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35477291
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35073410
55GATA2_19941826_ChIP-Seq_K562_Human1.33324730
56* P68_20966046_ChIP-Seq_HELA_Human1.32161676
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31882621
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.31788829
59CTCF_27219007_Chip-Seq_Bcells_Human1.31509751
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31418814
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28674254
62* BCOR_27268052_Chip-Seq_Bcells_Human1.26657700
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24572997
64* SMC4_20622854_ChIP-Seq_HELA_Human1.24566053
65AR_21909140_ChIP-Seq_LNCAP_Human1.24227355
66JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.24158697
67CLOCK_20551151_ChIP-Seq_293T_Human1.24019391
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23670725
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23449152
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22935884
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22288084
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22250086
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21100857
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19535739
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19010450
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18822386
77KDM2B_26808549_Chip-Seq_DND41_Human1.18804792
78* BCL6_27268052_Chip-Seq_Bcells_Human1.17569444
79* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16673470
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16370433
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.16351063
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14480625
83SA1_27219007_Chip-Seq_Bcells_Human1.14211374
84* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13526116
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.12785699
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12487017
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11776294
88FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09941597
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09940434
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.07629432
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07533812
92GATA1_22025678_ChIP-Seq_K562_Human1.07347935
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06690311
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06643257
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06142747
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05926219
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05651261
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04136706
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04117519
100ATF3_27146783_Chip-Seq_COLON_Human1.03662296
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03612603
102ETS1_21867929_ChIP-Seq_TH2_Mouse1.00935947
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00610342
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.00442825
105CDX2_22108803_ChIP-Seq_LS180_Human1.00290370
106HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99925739
107FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99900628
108TP63_23658742_ChIP-Seq_EP156T_Human0.97941642
109MYC_22102868_ChIP-Seq_BL_Human0.97868889
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97605768
111* E2F1_20622854_ChIP-Seq_HELA_Human0.97443255
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97147900
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96260218
114* PHF8_20622854_ChIP-Seq_HELA_Human0.96102620
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.95488011
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92555273
117CREB1_26743006_Chip-Seq_LNCaP_Human0.92501805
118CJUN_26792858_Chip-Seq_BT549_Human0.91464706
119* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91215484
120EGR1_19032775_ChIP-ChIP_M12_Human0.89723033
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87372401
122BCAT_22108803_ChIP-Seq_LS180_Human0.85746960
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85676855
124* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84445153
125* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84197307
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83064896
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82735370
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.81233819
129TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81185100
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79988722
131GATA1_19941826_ChIP-Seq_K562_Human0.79354467
132AHR_22903824_ChIP-Seq_MCF-7_Human0.78778168
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.78711940
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77993314
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77851278
136* DROSHA_22980978_ChIP-Seq_HELA_Human0.77679225
137RXR_22108803_ChIP-Seq_LS180_Human0.77099262
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.75615823
139SMAD_19615063_ChIP-ChIP_OVARY_Human0.74142102
140* GATA3_24758297_ChIP-Seq_MCF-7_Human0.74051187
141* LXR_22292898_ChIP-Seq_THP-1_Human0.73853281
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73755457
143GATA2_21666600_ChIP-Seq_HMVEC_Human0.73524938
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73307213
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.72908319
146TP63_22573176_ChIP-Seq_HFKS_Human0.72871466
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.72471607
148ZNF263_19887448_ChIP-Seq_K562_Human0.72069549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.44309920
2MP0001666_abnormal_nutrient_absorption5.42638985
3MP0002139_abnormal_hepatobiliary_system4.07966435
4MP0010234_abnormal_vibrissa_follicle3.83878630
5MP0003252_abnormal_bile_duct3.72812089
6MP0008875_abnormal_xenobiotic_pharmacok3.38430067
7MP0005085_abnormal_gallbladder_physiolo3.21562029
8MP0004264_abnormal_extraembryonic_tissu3.20453357
9MP0004019_abnormal_vitamin_homeostasis3.14485339
10MP0009379_abnormal_foot_pigmentation2.86939494
11MP0005409_darkened_coat_color2.80220704
12* MP0004043_abnormal_pH_regulation2.69326609
13MP0009840_abnormal_foam_cell2.69301367
14MP0005377_hearing/vestibular/ear_phenot2.69191755
15MP0003878_abnormal_ear_physiology2.69191755
16MP0001188_hyperpigmentation2.65109990
17MP0000462_abnormal_digestive_system2.61238393
18MP0003183_abnormal_peptide_metabolism2.48740349
19MP0005332_abnormal_amino_acid2.38120176
20MP0001765_abnormal_ion_homeostasis2.31197000
21MP0004147_increased_porphyrin_level2.29625833
22MP0009643_abnormal_urine_homeostasis2.26362507
23MP0005365_abnormal_bile_salt2.19988841
24* MP0003866_abnormal_defecation2.13185585
25MP0005670_abnormal_white_adipose2.05746687
26MP0010329_abnormal_lipoprotein_level2.05427334
27MP0000538_abnormal_urinary_bladder2.00265892
28MP0003300_gastrointestinal_ulcer1.92379284
29MP0005636_abnormal_mineral_homeostasis1.81580482
30MP0001664_abnormal_digestion1.72013290
31* MP0001663_abnormal_digestive_system1.69453724
32* MP0005381_digestive/alimentary_phenotyp1.69116921
33MP0010155_abnormal_intestine_physiology1.67837187
34MP0005084_abnormal_gallbladder_morpholo1.59643603
35MP0001873_stomach_inflammation1.59279397
36MP0001756_abnormal_urination1.58843911
37MP0002877_abnormal_melanocyte_morpholog1.56230641
38MP0002822_catalepsy1.49884773
39* MP0002136_abnormal_kidney_physiology1.49432556
40MP0003705_abnormal_hypodermis_morpholog1.48802648
41MP0006054_spinal_hemorrhage1.46693662
42MP0000537_abnormal_urethra_morphology1.44682113
43MP0002138_abnormal_hepatobiliary_system1.40751606
44MP0004782_abnormal_surfactant_physiolog1.39442281
45MP0004858_abnormal_nervous_system1.34989980
46MP0005174_abnormal_tail_pigmentation1.34085940
47* MP0000477_abnormal_intestine_morphology1.31210235
48MP0010352_gastrointestinal_tract_polyps1.24571424
49MP0000490_abnormal_crypts_of1.24429005
50MP0003283_abnormal_digestive_organ1.21796889
51MP0002089_abnormal_postnatal_growth/wei1.21510824
52MP0003195_calcinosis1.21217266
53MP0003191_abnormal_cellular_cholesterol1.19166740
54MP0002796_impaired_skin_barrier1.18306437
55MP0000566_synostosis1.17912914
56MP0005451_abnormal_body_composition1.17067130
57MP0005167_abnormal_blood-brain_barrier1.13209679
58MP0003303_peritoneal_inflammation1.04547363
59MP0002118_abnormal_lipid_homeostasis1.03041636
60MP0000465_gastrointestinal_hemorrhage1.02678858
61MP0009780_abnormal_chondrocyte_physiolo0.99736200
62MP0001849_ear_inflammation0.96055140
63MP0005319_abnormal_enzyme/_coenzyme0.91844273
64MP0002971_abnormal_brown_adipose0.88756334
65MP0000609_abnormal_liver_physiology0.88272393
66MP0005076_abnormal_cell_differentiation0.87197481
67MP0003806_abnormal_nucleotide_metabolis0.86965078
68MP0002249_abnormal_larynx_morphology0.85300140
69MP0003329_amyloid_beta_deposits0.84993325
70MP0009384_cardiac_valve_regurgitation0.83817106
71MP0005448_abnormal_energy_balance0.81619339
72MP0005584_abnormal_enzyme/coenzyme_acti0.81613840
73MP0010678_abnormal_skin_adnexa0.81143440
74MP0005166_decreased_susceptibility_to0.80810482
75MP0005501_abnormal_skin_physiology0.76239952
76MP0002876_abnormal_thyroid_physiology0.75698744
77MP0002098_abnormal_vibrissa_morphology0.73623736
78MP0008961_abnormal_basal_metabolism0.73273803
79MP0002166_altered_tumor_susceptibility0.72694023
80MP0002009_preneoplasia0.72398321
81MP0009697_abnormal_copulation0.72222669
82MP0000015_abnormal_ear_pigmentation0.70352850
83MP0002254_reproductive_system_inflammat0.70347303
84MP0004885_abnormal_endolymph0.69486768
85MP0009764_decreased_sensitivity_to0.68637924
86MP0003718_maternal_effect0.68630792
87MP0005257_abnormal_intraocular_pressure0.68496881
88MP0005310_abnormal_salivary_gland0.67851475
89MP0005375_adipose_tissue_phenotype0.67092992
90MP0005266_abnormal_metabolism0.66783193
91MP0000678_abnormal_parathyroid_gland0.66694708
92MP0004270_analgesia0.65832376
93MP0003045_fibrosis0.65440925
94MP0001958_emphysema0.65426835
95MP0008260_abnormal_autophagy0.65113851
96MP0001845_abnormal_inflammatory_respons0.64426701
97MP0008872_abnormal_physiological_respon0.63977002
98MP0002998_abnormal_bone_remodeling0.63536948
99MP0001764_abnormal_homeostasis0.60786570
100* MP0009642_abnormal_blood_homeostasis0.60052780
101MP0003436_decreased_susceptibility_to0.59963647
102MP0009333_abnormal_splenocyte_physiolog0.59911150
103MP0005535_abnormal_body_temperature0.59332268
104MP0004947_skin_inflammation0.59250154
105MP0003315_abnormal_perineum_morphology0.58080191
106MP0003638_abnormal_response/metabolism_0.58010309
107MP0005025_abnormal_response_to0.57943393
108MP0003091_abnormal_cell_migration0.57772190
109MP0003879_abnormal_hair_cell0.55882223
110* MP0000230_abnormal_systemic_arterial0.54958094
111MP0000681_abnormal_thyroid_gland0.53899660
112MP0003453_abnormal_keratinocyte_physiol0.53690445
113MP0004484_altered_response_of0.53362868
114MP0002396_abnormal_hematopoietic_system0.52806783
115MP0001501_abnormal_sleep_pattern0.52657740
116MP0002896_abnormal_bone_mineralization0.50052293
117MP0005666_abnormal_adipose_tissue0.48871522
118MP0001216_abnormal_epidermal_layer0.46696537
119MP0005395_other_phenotype0.44752474
120MP0002135_abnormal_kidney_morphology0.44180135
121MP0003868_abnormal_feces_composition0.43719965
122MP0000470_abnormal_stomach_morphology0.43498708
123MP0009053_abnormal_anal_canal0.43487966
124MP0009765_abnormal_xenobiotic_induced0.43375187
125MP0008004_abnormal_stomach_pH0.43142338
126MP0005376_homeostasis/metabolism_phenot0.42188673
127MP0005408_hypopigmentation0.37714167
128MP0009115_abnormal_fat_cell0.36901301
129MP0005058_abnormal_lysosome_morphology0.36592108
130MP0001191_abnormal_skin_condition0.36233858
131MP0000377_abnormal_hair_follicle0.36104033

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.79276177
2Hyperactive renin-angiotensin system (HP:0000841)6.67420521
3Abnormality of glutamine family amino acid metabolism (HP:0010902)6.46896094
4Ileus (HP:0002595)5.99386405
5Abnormality of chloride homeostasis (HP:0011422)5.86366021
6Increased circulating renin level (HP:0000848)5.20901037
7Hydroxyprolinuria (HP:0003080)5.02534030
8Abnormality of proline metabolism (HP:0010907)5.02534030
9Malnutrition (HP:0004395)4.97760611
10Hypokalemic alkalosis (HP:0001949)4.59183551
11Autoimmune thrombocytopenia (HP:0001973)4.55607677
12Hyperglycinuria (HP:0003108)4.39287269
13Hypomagnesemia (HP:0002917)4.28733438
14Abnormal urine output (HP:0012590)4.28700275
15Abnormality of renin-angiotensin system (HP:0000847)4.27016089
16Abnormality of renal excretion (HP:0011036)4.16966102
17Abnormality of magnesium homeostasis (HP:0004921)4.16179243
18Hyperaldosteronism (HP:0000859)4.12308225
19Acanthocytosis (HP:0001927)3.91752571
20Proximal tubulopathy (HP:0000114)3.87179976
21Gout (HP:0001997)3.85538451
22Polyuria (HP:0000103)3.83775888
23Alkalosis (HP:0001948)3.83150471
24Abnormality of purine metabolism (HP:0004352)3.75869366
25Conjugated hyperbilirubinemia (HP:0002908)3.73292724
26Hemorrhage of the eye (HP:0011885)3.71296446
27Hypobetalipoproteinemia (HP:0003563)3.63949341
28Dehydration (HP:0001944)3.63218826
29Widely patent fontanelles and sutures (HP:0004492)3.58980614
30Right ventricular cardiomyopathy (HP:0011663)3.55108579
31Glycosuria (HP:0003076)3.52906729
32Abnormality of urine glucose concentration (HP:0011016)3.52906729
33Tetany (HP:0001281)3.24146961
34Hypokalemia (HP:0002900)3.22754209
35Abnormality of glycine metabolism (HP:0010895)3.22708795
36Abnormality of serine family amino acid metabolism (HP:0010894)3.22708795
37Cupped ribs (HP:0000887)3.16722348
38Hypercalciuria (HP:0002150)3.14456953
39Facial shape deformation (HP:0011334)3.11522937
40Potter facies (HP:0002009)3.11522937
41Hyperuricemia (HP:0002149)3.11156816
42Increased purine levels (HP:0004368)3.11156816
43Nephrolithiasis (HP:0000787)3.07293496
44Abdominal distention (HP:0003270)3.02342520
45Autoimmune hemolytic anemia (HP:0001890)2.92940886
46Renal salt wasting (HP:0000127)2.90122881
47Chronic diarrhea (HP:0002028)2.84782270
48Abnormal drinking behavior (HP:0030082)2.79366802
49Polydipsia (HP:0001959)2.79366802
50Fat malabsorption (HP:0002630)2.77020749
51Abnormality of nucleobase metabolism (HP:0010932)2.71666389
52Hyperphosphaturia (HP:0003109)2.71371741
53Hyperparathyroidism (HP:0000843)2.66777966
54Thin bony cortex (HP:0002753)2.63157650
55Abnormality of potassium homeostasis (HP:0011042)2.60878164
56Neonatal short-limb short stature (HP:0008921)2.59738986
57Pigmentary retinal degeneration (HP:0001146)2.59254787
58Abnormality of the distal phalanx of the thumb (HP:0009617)2.57547700
59Pili torti (HP:0003777)2.54555755
60Abnormal urine phosphate concentration (HP:0012599)2.52059149
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51282558
62Delayed epiphyseal ossification (HP:0002663)2.50896280
63Flat acetabular roof (HP:0003180)2.47223324
64Ketoacidosis (HP:0001993)2.42734565
65Abnormal tarsal ossification (HP:0008369)2.39705082
66Systemic lupus erythematosus (HP:0002725)2.39159711
67Mesangial abnormality (HP:0001966)2.35512065
68Flattened epiphyses (HP:0003071)2.34837535
69Abnormality of the vitamin B12 metabolism (HP:0004341)2.33400861
70Xanthomatosis (HP:0000991)2.32274354
71Hypophosphatemia (HP:0002148)2.30018505
72Visceral angiomatosis (HP:0100761)2.29972246
73Generalized aminoaciduria (HP:0002909)2.29152254
74White forelock (HP:0002211)2.27278681
75Metabolic acidosis (HP:0001942)2.26282586
76Poikilocytosis (HP:0004447)2.26086901
77Congenital sensorineural hearing impairment (HP:0008527)2.22346806
78Vascular calcification (HP:0004934)2.21524938
79Gastrointestinal dysmotility (HP:0002579)2.14692246
80Abnormality of vitamin B metabolism (HP:0004340)2.14500507
81Confusion (HP:0001289)2.12935830
82Hypolipoproteinemia (HP:0010981)2.11810432
83Increased IgE level (HP:0003212)2.09800181
84Hyperammonemia (HP:0001987)2.07256222
85Hyponatremia (HP:0002902)2.06528798
86Adrenal overactivity (HP:0002717)2.06479725
87Renal tubular acidosis (HP:0001947)2.06459720
88Wide cranial sutures (HP:0010537)2.06438118
89Abnormal hair laboratory examination (HP:0003328)2.04337386
90Abnormality of sulfur amino acid metabolism (HP:0004339)2.03032900
91Hemangiomatosis (HP:0007461)2.01614685
92Intrahepatic cholestasis (HP:0001406)2.01042486
93Eczematoid dermatitis (HP:0000976)1.99991727
94Abnormality of sodium homeostasis (HP:0010931)1.99440233
95Abnormality of fatty-acid metabolism (HP:0004359)1.99146483
96Cardiovascular calcification (HP:0011915)1.97363906
97Patchy hypopigmentation of hair (HP:0011365)1.95393821
98Growth hormone excess (HP:0000845)1.94993418
99Gastrointestinal stroma tumor (HP:0100723)1.93865604
100Decreased circulating renin level (HP:0003351)1.93716042
101Mildly elevated creatine phosphokinase (HP:0008180)1.93224155
102Bone pain (HP:0002653)1.92391503
103Glomerulosclerosis (HP:0000096)1.91424449
104Hyperkalemia (HP:0002153)1.90859679
105Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90784051
106Rickets (HP:0002748)1.88872489
107Segmental peripheral demyelination/remyelination (HP:0003481)1.87915878
108Enlarged epiphyses (HP:0010580)1.87055890
109Hyperphosphatemia (HP:0002905)1.84331776
110Spinal cord compression (HP:0002176)1.81742799
111Sensorimotor neuropathy (HP:0007141)1.81474167
112Hypotension (HP:0002615)1.80594395
113Abnormality of alkaline phosphatase activity (HP:0004379)1.80373030
114Abnormal enzyme/coenzyme activity (HP:0012379)1.79732284
115Abnormality of carpal bone ossification (HP:0006257)1.79522451
116Ketosis (HP:0001946)1.79482524
117Distal lower limb amyotrophy (HP:0008944)1.78317935
118Broad face (HP:0000283)1.75679702
119Abnormality of the costochondral junction (HP:0000919)1.75470347
120Abnormal glucose tolerance (HP:0001952)1.73805020
121Villous atrophy (HP:0011473)1.73728114
122Abnormality of small intestinal villus morphology (HP:0011472)1.73728114
123Metaphyseal cupping (HP:0003021)1.73413451
124Germ cell neoplasia (HP:0100728)1.73397408
125Focal segmental glomerulosclerosis (HP:0000097)1.73136374
126Nephrocalcinosis (HP:0000121)1.72887803
127Elevated alkaline phosphatase (HP:0003155)1.71612348
128Protuberant abdomen (HP:0001538)1.71606553
129Abnormality of vitamin metabolism (HP:0100508)1.71604898
130Ankle clonus (HP:0011448)1.69776754
131Abnormal platelet function (HP:0011869)1.68652989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.40877220
2MST44.81804882
3WNK44.50769194
4MST1R4.19781224
5LMTK24.16366228
6WNK34.14123964
7ACVR1B4.12639548
8OXSR14.10521692
9TRIB32.64653123
10PRPF4B2.52887502
11PRKG22.46785369
12RIPK12.40263306
13STK392.29691165
14GRK62.27490966
15NME12.13450813
16EPHA21.92589220
17PTK61.90990287
18AKT31.89871144
19MAP3K21.75923026
20SMG11.69512117
21MAP3K101.67656531
22MAP2K21.61967289
23MYLK1.57400799
24SIK11.44249943
25MET1.41347488
26EPHB21.35885579
27KIT1.34270909
28LATS11.33455004
29STK101.31152248
30NUAK11.30060457
31TESK11.29037248
32EPHB11.23221709
33STK38L1.13652970
34MAP4K11.13449378
35ERN11.13397386
36CDC42BPA1.11383357
37MAP3K71.07860644
38PTK21.05666774
39KSR21.04344380
40TAOK10.99358771
41FER0.98648438
42ERBB40.95382610
43TYK20.94856597
44PRKAA20.94442223
45MAPK150.92537461
46PDK30.91935977
47PDK40.91935977
48PDK20.91393893
49PAK40.89703840
50TAOK30.88168900
51PKN20.87812159
52DDR20.87558674
53PRKCI0.87376292
54PIK3CA0.85974208
55FGFR30.84402059
56RPS6KA20.83329900
57WNK10.80561004
58BMX0.79400044
59PRKAA10.77992263
60ERBB20.76046014
61LRRK20.75602040
62MATK0.75582349
63EPHA30.75263853
64STK240.75211296
65NEK10.73857792
66RIPK40.72730311
67MAP3K60.72230832
68CDK120.70808091
69MAP3K80.69108722
70TTK0.67021250
71RET0.64798869
72MAP3K140.64702001
73MAPK110.63032816
74MAP2K10.61853584
75SGK30.61802070
76PDPK10.59555356
77MAP3K90.59266532
78PAK30.58253506
79DMPK0.55971752
80IRAK30.54469971
81SGK4940.53999420
82SGK2230.53999420
83TESK20.49334355
84STK30.47832449
85INSRR0.45199540
86SCYL20.43616097
87DYRK1B0.43063954
88EPHA40.42800218
89STK380.42253139
90ICK0.40907953
91MTOR0.40286603
92GSK3A0.40215234
93MAPKAPK30.39984612
94PRKD20.39880272
95CAMK2D0.38898950
96MAP3K10.38853648
97ZAP700.38639873
98MAP3K30.38482436
99BCKDK0.38097862
100PDK10.35884648
101ROCK10.34875866
102MAP2K60.32404571
103LIMK10.31653394
104MAPK70.31599008
105FGFR40.31453099
106MARK20.29947532
107NEK60.29932319
108RPS6KC10.29403585
109RPS6KL10.29403585
110PRKCA0.28450242
111STK110.27184532
112CSK0.27028415
113MAPKAPK20.26904625
114PAK20.26343373
115CSNK1A10.25425562
116SGK20.25075902
117MAP3K110.24631957
118PRKACG0.24517103
119CSF1R0.24300375
120ABL20.23805720
121SRC0.23391019
122JAK10.22423797
123FYN0.22390645
124SIK30.22137691
125EEF2K0.20902846
126PDGFRB0.19850623
127MELK0.19326263
128MAP3K130.19122276
129TBK10.19003522
130PDGFRA0.17605147
131PRKCD0.16491662
132GRK10.16109301
133AKT20.15989605
134FGR0.15415439
135CDK60.14717969
136PRKCZ0.13649660
137CAMK2G0.12809101
138PAK10.10183936

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.24737087
2Vitamin digestion and absorption_Homo sapiens_hsa049773.72940560
3* Mineral absorption_Homo sapiens_hsa049783.72081760
4Renin-angiotensin system_Homo sapiens_hsa046143.34532715
5Sulfur metabolism_Homo sapiens_hsa009203.18865501
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.18515489
7Starch and sucrose metabolism_Homo sapiens_hsa005002.54236896
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48046164
9Caffeine metabolism_Homo sapiens_hsa002322.47166879
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.45494699
11Folate biosynthesis_Homo sapiens_hsa007902.25383186
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.25257970
13Galactose metabolism_Homo sapiens_hsa000522.18970075
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.17929396
15* Bile secretion_Homo sapiens_hsa049762.12762184
16* Protein digestion and absorption_Homo sapiens_hsa049742.02093281
17* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00915561
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78323149
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76494038
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73040861
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70478139
22Fructose and mannose metabolism_Homo sapiens_hsa000511.64037711
23Butanoate metabolism_Homo sapiens_hsa006501.61964579
24Tryptophan metabolism_Homo sapiens_hsa003801.61946021
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.57485189
26Fatty acid degradation_Homo sapiens_hsa000711.53311492
27Histidine metabolism_Homo sapiens_hsa003401.47500970
28PPAR signaling pathway_Homo sapiens_hsa033201.40478435
29Glutathione metabolism_Homo sapiens_hsa004801.36387813
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31155574
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26669600
32Glycerolipid metabolism_Homo sapiens_hsa005611.25856056
33Pyruvate metabolism_Homo sapiens_hsa006201.24266576
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21716059
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18579342
36Propanoate metabolism_Homo sapiens_hsa006401.16705220
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15870883
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10632868
39Arginine biosynthesis_Homo sapiens_hsa002201.06217712
40Arginine and proline metabolism_Homo sapiens_hsa003301.02882569
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02326328
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01509814
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01204038
44Peroxisome_Homo sapiens_hsa041461.00509725
45ABC transporters_Homo sapiens_hsa020101.00435395
46Carbon metabolism_Homo sapiens_hsa012000.99902384
47Sphingolipid metabolism_Homo sapiens_hsa006000.96536628
48beta-Alanine metabolism_Homo sapiens_hsa004100.96284673
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92223291
50Nitrogen metabolism_Homo sapiens_hsa009100.90745518
51Sulfur relay system_Homo sapiens_hsa041220.86692811
52Fatty acid metabolism_Homo sapiens_hsa012120.84885336
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83276926
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79637257
55Thyroid hormone synthesis_Homo sapiens_hsa049180.78399901
56Gastric acid secretion_Homo sapiens_hsa049710.70040360
57Pancreatic secretion_Homo sapiens_hsa049720.67563911
58Lysine degradation_Homo sapiens_hsa003100.60135033
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60050649
60Tight junction_Homo sapiens_hsa045300.59835544
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57231483
62Pentose phosphate pathway_Homo sapiens_hsa000300.51083471
63Chemical carcinogenesis_Homo sapiens_hsa052040.50344326
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.48498354
65GnRH signaling pathway_Homo sapiens_hsa049120.48253875
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48036583
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.47520547
68Tyrosine metabolism_Homo sapiens_hsa003500.47226439
69Asthma_Homo sapiens_hsa053100.43769661
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.43288217
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.43181000
72Biosynthesis of amino acids_Homo sapiens_hsa012300.42578457
73Retinol metabolism_Homo sapiens_hsa008300.42453391
74Collecting duct acid secretion_Homo sapiens_hsa049660.42128134
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40830076
76Other glycan degradation_Homo sapiens_hsa005110.40193030
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39303227
78Selenocompound metabolism_Homo sapiens_hsa004500.38156890
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38087157
80Allograft rejection_Homo sapiens_hsa053300.34732279
81Metabolic pathways_Homo sapiens_hsa011000.32850213
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32707420
83Glucagon signaling pathway_Homo sapiens_hsa049220.32696279
84AMPK signaling pathway_Homo sapiens_hsa041520.31198727
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.31190453
86Acute myeloid leukemia_Homo sapiens_hsa052210.30708723
87Vibrio cholerae infection_Homo sapiens_hsa051100.30088877
88Notch signaling pathway_Homo sapiens_hsa043300.29833031
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.29215126
90Arachidonic acid metabolism_Homo sapiens_hsa005900.28687131
91Autoimmune thyroid disease_Homo sapiens_hsa053200.28300289
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27790097
93Salivary secretion_Homo sapiens_hsa049700.27531223
94Bladder cancer_Homo sapiens_hsa052190.26646511
95Phenylalanine metabolism_Homo sapiens_hsa003600.26220400
96Toxoplasmosis_Homo sapiens_hsa051450.25194996
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.25178504
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24317831
99Type II diabetes mellitus_Homo sapiens_hsa049300.23153605
100Inositol phosphate metabolism_Homo sapiens_hsa005620.22835783
101Hepatitis C_Homo sapiens_hsa051600.22404926
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22168408
103Steroid biosynthesis_Homo sapiens_hsa001000.21859691
104Graft-versus-host disease_Homo sapiens_hsa053320.21809661
105Renin secretion_Homo sapiens_hsa049240.21401390
106Adherens junction_Homo sapiens_hsa045200.21137010
107Salmonella infection_Homo sapiens_hsa051320.20580150
108Choline metabolism in cancer_Homo sapiens_hsa052310.20325845
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.20201458
110Endometrial cancer_Homo sapiens_hsa052130.17924672
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17743232
112Insulin signaling pathway_Homo sapiens_hsa049100.17388524
113Leishmaniasis_Homo sapiens_hsa051400.17359580
114Insulin resistance_Homo sapiens_hsa049310.16917644
115Fatty acid biosynthesis_Homo sapiens_hsa000610.16653997
116Cocaine addiction_Homo sapiens_hsa050300.16402064
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12574065
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10089097
119Amoebiasis_Homo sapiens_hsa051460.08646460
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.08604355
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08527475
122Insulin secretion_Homo sapiens_hsa049110.07700132
123Thyroid cancer_Homo sapiens_hsa052160.04856407
124Linoleic acid metabolism_Homo sapiens_hsa005910.04704092
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.04118872
126Ether lipid metabolism_Homo sapiens_hsa005650.02612997

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