SLC9A3P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of growth hormone secretion (GO:0060124)7.00201787
2lens morphogenesis in camera-type eye (GO:0002089)6.74017848
3growth hormone secretion (GO:0030252)6.07456350
4cellular ketone body metabolic process (GO:0046950)6.02625207
5regulation of growth hormone secretion (GO:0060123)5.86874634
6ketone body metabolic process (GO:1902224)5.35706803
7forebrain neuron differentiation (GO:0021879)5.18786774
8phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.15995845
9cell-cell junction maintenance (GO:0045217)5.07833857
10adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.04456097
11positive regulation of fatty acid beta-oxidation (GO:0032000)5.02198123
12regulation of energy homeostasis (GO:2000505)4.54975630
13positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.48076506
14apical protein localization (GO:0045176)4.42209830
15ear development (GO:0043583)4.37690704
16histone H4-K12 acetylation (GO:0043983)4.25658450
17cell junction maintenance (GO:0034331)4.23754083
18seminiferous tubule development (GO:0072520)4.18854558
19dopaminergic neuron differentiation (GO:0071542)4.12565921
20dopamine biosynthetic process (GO:0042416)4.10856574
21positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.07492550
22activation of adenylate cyclase activity (GO:0007190)4.06853791
23autophagic vacuole fusion (GO:0000046)4.04431607
24positive regulation of cAMP-mediated signaling (GO:0043950)3.98237380
25regulation of lipoprotein metabolic process (GO:0050746)3.95385007
26coenzyme catabolic process (GO:0009109)3.83971526
27mitochondrial fusion (GO:0008053)3.82184713
28cAMP-mediated signaling (GO:0019933)3.78720487
29superoxide anion generation (GO:0042554)3.76323538
30determination of adult lifespan (GO:0008340)3.69566258
31response to insecticide (GO:0017085)3.63747697
32somite development (GO:0061053)3.57906886
33basic amino acid transport (GO:0015802)3.55948722
34limb bud formation (GO:0060174)3.55152618
35negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.52879722
36NIK/NF-kappaB signaling (GO:0038061)3.51051936
37positive regulation of adenylate cyclase activity (GO:0045762)3.48012214
38regulation of G0 to G1 transition (GO:0070316)3.47798148
39peptidyl-arginine N-methylation (GO:0035246)3.47023233
40peptidyl-arginine methylation (GO:0018216)3.47023233
41regulation of metalloenzyme activity (GO:0048552)3.42480558
42mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.42183233
43regulation of protein targeting to membrane (GO:0090313)3.40757184
44lateral ventricle development (GO:0021670)3.37449388
45catechol-containing compound biosynthetic process (GO:0009713)3.36443714
46catecholamine biosynthetic process (GO:0042423)3.36443714
47synaptic transmission, dopaminergic (GO:0001963)3.34848541
48positive regulation of mitochondrial fission (GO:0090141)3.31793153
49natural killer cell differentiation (GO:0001779)3.23272275
50regulation of chromatin binding (GO:0035561)3.23143124
51regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.20769126
52alternative mRNA splicing, via spliceosome (GO:0000380)3.19424144
53response to amphetamine (GO:0001975)3.18533642
54microtubule severing (GO:0051013)3.16054212
55norepinephrine metabolic process (GO:0042415)3.14882188
56thrombin receptor signaling pathway (GO:0070493)3.10919377
57positive regulation of fatty acid oxidation (GO:0046321)3.10369809
58establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.09643165
59regulation of mitochondrial fission (GO:0090140)3.09179105
60proline transport (GO:0015824)3.07018504
61regulation of chemokine-mediated signaling pathway (GO:0070099)3.04391074
62negative regulation of gene silencing (GO:0060969)3.01930659
63regulation of inositol phosphate biosynthetic process (GO:0010919)2.97037070
64positive regulation of lyase activity (GO:0051349)2.95417977
65female genitalia development (GO:0030540)2.94904778
66somite rostral/caudal axis specification (GO:0032525)2.92479608
67hindbrain development (GO:0030902)2.92315013
68central nervous system projection neuron axonogenesis (GO:0021952)2.91077916
69cornea development in camera-type eye (GO:0061303)2.90197087
70positive regulation of cyclase activity (GO:0031281)2.90164453
71purine deoxyribonucleotide catabolic process (GO:0009155)2.89313241
72kidney morphogenesis (GO:0060993)2.87841530
73adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.82879007
74regulation of female receptivity (GO:0045924)2.82668485
75sperm capacitation (GO:0048240)2.81041230
76DNA integration (GO:0015074)2.80263326
77cyclic-nucleotide-mediated signaling (GO:0019935)2.80167077
78actin filament depolymerization (GO:0030042)2.79225995
79response to dietary excess (GO:0002021)2.79186174
80otic vesicle formation (GO:0030916)2.77812736
81regulation of ruffle assembly (GO:1900027)2.77628105
82nucleoside diphosphate catabolic process (GO:0009134)2.77488335
83RNA localization (GO:0006403)2.77370542
84neural tube formation (GO:0001841)2.75742498
85positive regulation of actin filament depolymerization (GO:0030836)2.75481413
86positive regulation of protein depolymerization (GO:1901881)2.73932261
87synaptonemal complex assembly (GO:0007130)2.73002619
88adaptation of signaling pathway (GO:0023058)2.72039397
89auditory behavior (GO:0031223)2.71193918
90negative regulation of axon guidance (GO:1902668)2.70760290
91negative regulation of mast cell activation (GO:0033004)2.70468266
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69402462
93response to UV-C (GO:0010225)2.64761864
94uterus development (GO:0060065)2.62193590
95midbrain development (GO:0030901)2.58746600
96regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.57904704
97negative regulation of organelle assembly (GO:1902116)2.55303038
98male genitalia development (GO:0030539)2.55240990
99pyrimidine nucleobase catabolic process (GO:0006208)2.53465776
100sequestering of actin monomers (GO:0042989)10.3882647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.12095493
2GBX2_23144817_ChIP-Seq_PC3_Human3.40572048
3VDR_22108803_ChIP-Seq_LS180_Human3.27487692
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.25832194
5DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.23515408
6IGF1R_20145208_ChIP-Seq_DFB_Human2.95366410
7IRF1_19129219_ChIP-ChIP_H3396_Human2.90759937
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.64764814
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58882531
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.50546401
11TAF15_26573619_Chip-Seq_HEK293_Human2.01522178
12CBX2_27304074_Chip-Seq_ESCs_Mouse1.92266593
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91844666
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91135465
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90452067
16AHR_22903824_ChIP-Seq_MCF-7_Human1.89510514
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88950783
18POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85548405
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.80552658
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78773005
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75879025
22SRY_22984422_ChIP-ChIP_TESTIS_Rat1.72727505
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.67833634
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63828100
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.59252441
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58146171
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56473011
28CBP_20019798_ChIP-Seq_JUKART_Human1.55406832
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55406832
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54465963
31ZNF274_21170338_ChIP-Seq_K562_Hela1.54354371
32CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51892305
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.49712425
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.49616232
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.49174705
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49142905
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49048782
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48427739
39REST_21632747_ChIP-Seq_MESCs_Mouse1.45153359
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44341718
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43774232
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42703542
43P300_19829295_ChIP-Seq_ESCs_Human1.41345215
44DROSHA_22980978_ChIP-Seq_HELA_Human1.40859907
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.40339781
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37585454
47P53_22127205_ChIP-Seq_FIBROBLAST_Human1.36407888
48SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.29416476
49ER_23166858_ChIP-Seq_MCF-7_Human1.28365537
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27745492
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27493525
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27422735
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.23611449
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22411140
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22091535
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.19736435
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19474089
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16497721
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.15955057
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15344979
61CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14283198
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.13456404
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10830996
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07539066
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07218790
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05733376
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05363305
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.04940600
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04783230
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.03407223
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.03152699
72RXR_22108803_ChIP-Seq_LS180_Human1.03133980
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02103173
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.00188123
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99896343
76KDM2B_26808549_Chip-Seq_REH_Human0.98975647
77SMAD3_21741376_ChIP-Seq_ESCs_Human0.98205522
78MYC_18940864_ChIP-ChIP_HL60_Human0.98111751
79CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97509810
80ERG_20517297_ChIP-Seq_VCAP_Human0.97279713
81RNF2_27304074_Chip-Seq_ESCs_Mouse0.97192477
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96769223
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96479328
84TCF4_22108803_ChIP-Seq_LS180_Human0.95929982
85RUNX2_22187159_ChIP-Seq_PCA_Human0.95825045
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95334976
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94699290
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94650413
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93787310
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93524049
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.93314348
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93167399
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92712039
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92689697
95ETV1_20927104_ChIP-Seq_GIST48_Human0.92149135
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91254761
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.89085599
98EWS_26573619_Chip-Seq_HEK293_Human0.88905659
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88140764
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87012721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol5.22184765
2MP0000569_abnormal_digit_pigmentation4.76034847
3MP0003011_delayed_dark_adaptation3.15535570
4MP0001501_abnormal_sleep_pattern2.99947596
5MP0002909_abnormal_adrenal_gland2.97833078
6MP0005423_abnormal_somatic_nervous2.94996234
7MP0002736_abnormal_nociception_after2.88085677
8MP0009379_abnormal_foot_pigmentation2.76384137
9MP0003186_abnormal_redox_activity2.63247263
10MP0000372_irregular_coat_pigmentation2.57257412
11MP0003880_abnormal_central_pattern2.50540256
12MP0001905_abnormal_dopamine_level2.45604950
13MP0003315_abnormal_perineum_morphology2.29423345
14MP0001968_abnormal_touch/_nociception2.27574031
15MP0009697_abnormal_copulation2.25426002
16MP0004885_abnormal_endolymph2.14624033
17MP0002277_abnormal_respiratory_mucosa2.12053062
18MP0005671_abnormal_response_to2.09779977
19MP0005187_abnormal_penis_morphology1.99003229
20MP0002751_abnormal_autonomic_nervous1.95621496
21MP0000015_abnormal_ear_pigmentation1.89318564
22MP0000631_abnormal_neuroendocrine_gland1.82346207
23MP0001485_abnormal_pinna_reflex1.79746205
24MP0005266_abnormal_metabolism1.76859934
25MP0003959_abnormal_lean_body1.75028818
26MP0002184_abnormal_innervation1.74055871
27MP0006276_abnormal_autonomic_nervous1.69945206
28MP0000462_abnormal_digestive_system1.67080851
29MP0000534_abnormal_ureter_morphology1.58856078
30MP0001881_abnormal_mammary_gland1.55526821
31MP0002102_abnormal_ear_morphology1.54018117
32MP0008961_abnormal_basal_metabolism1.49192014
33MP0002733_abnormal_thermal_nociception1.47402783
34MP0001919_abnormal_reproductive_system1.46653313
35MP0005174_abnormal_tail_pigmentation1.44496440
36MP0005171_absent_coat_pigmentation1.43203353
37MP0003787_abnormal_imprinting1.39981767
38MP0000049_abnormal_middle_ear1.29046707
39MP0008872_abnormal_physiological_respon1.27737387
40MP0003283_abnormal_digestive_organ1.27529582
41MP0004133_heterotaxia1.23270069
42MP0006035_abnormal_mitochondrial_morpho1.22952789
43MP0002876_abnormal_thyroid_physiology1.19531553
44MP0008789_abnormal_olfactory_epithelium1.16113174
45MP0000778_abnormal_nervous_system1.13950102
46MP0003252_abnormal_bile_duct1.11835516
47MP0005503_abnormal_tendon_morphology1.03047835
48MP0000639_abnormal_adrenal_gland1.02407352
49MP0002067_abnormal_sensory_capabilities1.01781830
50MP0001664_abnormal_digestion0.99330005
51MP0000230_abnormal_systemic_arterial0.99083238
52MP0003632_abnormal_nervous_system0.94331984
53MP0005389_reproductive_system_phenotype0.91882056
54MP0003635_abnormal_synaptic_transmissio0.91554510
55MP0004742_abnormal_vestibular_system0.91189585
56MP0003936_abnormal_reproductive_system0.88414211
57MP0003385_abnormal_body_wall0.87034346
58MP0002653_abnormal_ependyma_morphology0.86495365
59MP0000538_abnormal_urinary_bladder0.86161345
60MP0003937_abnormal_limbs/digits/tail_de0.85889797
61MP0001502_abnormal_circadian_rhythm0.84115644
62MP0000467_abnormal_esophagus_morphology0.83850792
63MP0002069_abnormal_eating/drinking_beha0.83467818
64MP0000427_abnormal_hair_cycle0.83285131
65MP0003698_abnormal_male_reproductive0.81301551
66MP0004883_abnormal_blood_vessel0.81207896
67MP0000358_abnormal_cell_content/0.80383113
68MP0002064_seizures0.78139387
69MP0002177_abnormal_outer_ear0.77984962
70MP0000383_abnormal_hair_follicle0.77794410
71MP0003638_abnormal_response/metabolism_0.77618298
72MP0000955_abnormal_spinal_cord0.77437156
73MP0002933_joint_inflammation0.77316416
74MP0002882_abnormal_neuron_morphology0.77006599
75MP0003942_abnormal_urinary_system0.76013019
76MP0001970_abnormal_pain_threshold0.74736760
77MP0005647_abnormal_sex_gland0.74453347
78MP0002095_abnormal_skin_pigmentation0.73587171
79MP0001542_abnormal_bone_strength0.72865345
80MP0003806_abnormal_nucleotide_metabolis0.72644568
81MP0002136_abnormal_kidney_physiology0.71621190
82MP0001756_abnormal_urination0.68935754
83MP0005595_abnormal_vascular_smooth0.68639024
84MP0003866_abnormal_defecation0.68173758
85MP0002752_abnormal_somatic_nervous0.67880980
86MP0009764_decreased_sensitivity_to0.66900117
87MP0002295_abnormal_pulmonary_circulatio0.66506223
88MP0002272_abnormal_nervous_system0.65825375
89MP0002734_abnormal_mechanical_nocicepti0.64977813
90MP0005551_abnormal_eye_electrophysiolog0.64389278
91MP0009745_abnormal_behavioral_response0.63834026
92MP0003938_abnormal_ear_development0.62065317
93MP0005499_abnormal_olfactory_system0.60025302
94MP0005394_taste/olfaction_phenotype0.60025302
95MP0002229_neurodegeneration0.59053602
96MP0010329_abnormal_lipoprotein_level0.58780708
97MP0005167_abnormal_blood-brain_barrier0.57425193
98MP0002938_white_spotting0.56997191
99MP0001486_abnormal_startle_reflex0.56899439
100MP0004811_abnormal_neuron_physiology0.56702054

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)9.38521665
2Abnormality of cells of the erythroid lineage (HP:0012130)8.31054818
3Severe visual impairment (HP:0001141)5.47897765
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.72494711
5Sensory axonal neuropathy (HP:0003390)4.53882766
6Gonadotropin excess (HP:0000837)4.31053025
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.83927632
8Poikilocytosis (HP:0004447)3.73632254
9Tubulointerstitial fibrosis (HP:0005576)3.46106343
10Hypoplastic left heart (HP:0004383)3.35258462
11Severe combined immunodeficiency (HP:0004430)3.29524838
12Enlarged penis (HP:0000040)3.26929827
13Chronic bronchitis (HP:0004469)3.20415488
14Abnormality of incisor morphology (HP:0011063)3.12541532
15Increased intramyocellular lipid droplets (HP:0012240)3.00174904
16Thyroiditis (HP:0100646)2.93554049
17Morphological abnormality of the middle ear (HP:0008609)2.89352522
18Reticulocytosis (HP:0001923)2.87554705
19Constricted visual fields (HP:0001133)2.81231443
20Tubulointerstitial abnormality (HP:0001969)2.79772987
21Homocystinuria (HP:0002156)2.79290925
22Abnormality of homocysteine metabolism (HP:0010919)2.79290925
23Parakeratosis (HP:0001036)2.75573721
24Type II lissencephaly (HP:0007260)2.75556331
25Hypoplastic heart (HP:0001961)2.74449404
26Methylmalonic acidemia (HP:0002912)2.71799695
27Pallor (HP:0000980)2.71570149
28Abnormality of the lower motor neuron (HP:0002366)2.68495919
29Nemaline bodies (HP:0003798)2.67346007
30Hyperlipoproteinemia (HP:0010980)2.66078755
31Increased muscle lipid content (HP:0009058)2.58906003
32Focal motor seizures (HP:0011153)2.56031768
33Nuclear cataract (HP:0100018)2.52323034
34Increased hepatocellular lipid droplets (HP:0006565)2.49098728
35Focal segmental glomerulosclerosis (HP:0000097)2.48424125
36Combined immunodeficiency (HP:0005387)2.45980822
37Keratoconjunctivitis sicca (HP:0001097)2.45301654
38Growth hormone deficiency (HP:0000824)2.44369809
39Abnormal umbilical cord blood vessels (HP:0011403)2.39333458
40Single umbilical artery (HP:0001195)2.39333458
41Abnormality of the fetal cardiovascular system (HP:0010948)2.39333458
42Esophageal atresia (HP:0002032)2.39048116
43Tetraparesis (HP:0002273)2.33928679
44Bony spicule pigmentary retinopathy (HP:0007737)2.33607059
45Adrenal hypoplasia (HP:0000835)2.33576286
46Retinitis pigmentosa (HP:0000510)2.29755045
47Lipid accumulation in hepatocytes (HP:0006561)2.23578448
48Neoplasm of head and neck (HP:0012288)2.21753807
49Esophageal neoplasm (HP:0100751)2.21753807
50Keratoconjunctivitis (HP:0001096)2.20715575
51Aplasia of the musculature (HP:0100854)2.20289860
52Hydroxyprolinuria (HP:0003080)2.18205533
53Abnormality of proline metabolism (HP:0010907)2.18205533
54Glomerulosclerosis (HP:0000096)2.18198194
55Cerebral hypomyelination (HP:0006808)2.17972432
56Slow saccadic eye movements (HP:0000514)2.14578887
57Abnormal respiratory motile cilium physiology (HP:0012261)2.14029895
58Pigmentary retinal degeneration (HP:0001146)2.12533279
59Amblyopia (HP:0000646)2.12382827
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.12357417
61Conical tooth (HP:0000698)2.10989276
62Complete atrioventricular canal defect (HP:0001674)2.09265405
63Abnormal number of incisors (HP:0011064)2.09068744
64Renal Fanconi syndrome (HP:0001994)2.07124053
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.04059800
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02658601
67Acne (HP:0001061)2.01757137
68Abnormal rod and cone electroretinograms (HP:0008323)2.00427384
69Rhinitis (HP:0012384)1.99995188
70Arthropathy (HP:0003040)1.99580902
71Myelomeningocele (HP:0002475)1.93944061
72Abnormality of the renal cortex (HP:0011035)1.93177916
73Cupped ear (HP:0000378)1.93074172
74Concave nail (HP:0001598)1.92707931
75Anterior segment dysgenesis (HP:0007700)1.92354355
76Flat capital femoral epiphysis (HP:0003370)1.90252260
77Cerebellar dysplasia (HP:0007033)1.86939836
78Prostate neoplasm (HP:0100787)1.86686167
79Severe muscular hypotonia (HP:0006829)1.86620423
80Palpebral edema (HP:0100540)1.86281769
81Muscle fiber inclusion bodies (HP:0100299)1.85653114
82Hypoalbuminemia (HP:0003073)1.84955505
83Abnormal albumin level (HP:0012116)1.84955505
84Tubular atrophy (HP:0000092)1.80311038
85Retinal atrophy (HP:0001105)1.78892096
86Meningocele (HP:0002435)1.77466865
87Polydipsia (HP:0001959)1.77033517
88Abnormal drinking behavior (HP:0030082)1.77033517
89Mixed hearing impairment (HP:0000410)1.74947842
90Chronic diarrhea (HP:0002028)1.73190687
91Mask-like facies (HP:0000298)1.69556830
92Lissencephaly (HP:0001339)1.69483796
93Increased cerebral lipofuscin (HP:0011813)1.69174642
94Abnormality of reticulocytes (HP:0004312)1.67818850
95Stage 5 chronic kidney disease (HP:0003774)1.66366308
96Abnormality of the vitamin B12 metabolism (HP:0004341)1.65571857
97Spontaneous hematomas (HP:0007420)1.65403986
98Abnormality of the incisor (HP:0000676)1.64950215
99Muscular hypotonia of the trunk (HP:0008936)1.63364704
100Spastic gait (HP:0002064)1.62718424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.52419073
2CLK14.19443922
3LIMK14.02902142
4FLT33.53204296
5ICK3.46437703
6MAP3K123.29922260
7TESK22.72557659
8CAMK1D2.45277742
9ERBB32.40003168
10MAP3K42.15385633
11CAMKK22.03756046
12DYRK22.00620513
13BCKDK1.95235897
14PINK11.92707573
15TRPM71.90930714
16EPHA41.81784878
17MAP3K61.81013302
18EPHA31.60274050
19CAMK1G1.59727454
20KDR1.54837037
21TAOK31.54030975
22ADRBK21.53431581
23MYLK1.51907958
24BMPR1B1.51034951
25CAMK2B1.51012449
26GRK61.41910492
27MARK11.35116270
28TGFBR11.32936308
29MAP4K11.25954602
30CASK1.25569850
31PASK1.23161558
32TXK1.19126548
33TESK11.18143708
34CAMK2G1.14609251
35PAK31.14480785
36DAPK11.14164320
37NEK11.10006656
38DYRK31.05571423
39MAPK131.02716858
40GRK10.97274199
41TIE10.96773518
42CAMK2D0.95375645
43CAMKK10.93685147
44CDK90.92646336
45BRSK20.92303354
46PDGFRB0.90142257
47CAMK10.82214835
48BMPR20.80125439
49OXSR10.79282312
50MAPKAPK50.78200466
51GRK50.77647663
52CDK80.75612984
53CDK190.73870949
54RPS6KA40.73829199
55MAP3K110.72946728
56PAK60.69555573
57KIT0.67373268
58LRRK20.66884613
59FRK0.65831589
60STK390.64839014
61NEK20.64380605
62ERBB40.61061324
63ROCK10.60937974
64MAPKAPK30.60582173
65TLK10.57403331
66WNK30.55777501
67CAMK2A0.55138153
68BTK0.54191930
69MKNK10.53762641
70BMX0.52080766
71MARK30.52061909
72CAMK40.51264489
73IKBKE0.50900246
74GSK3A0.50072797
75MAPK40.48491073
76PIM10.45487289
77NTRK20.44862246
78PRKD30.44821988
79PRKCE0.44421450
80PRKG20.41153462
81UHMK10.40459745
82SYK0.39532804
83CSF1R0.37433981
84IRAK40.36692011
85INSRR0.36575800
86FER0.34476967
87DYRK1B0.33602305
88ERBB20.32845786
89MKNK20.32286699
90YES10.31592504
91FGFR10.31350189
92DYRK1A0.31288465
93ABL10.31275729
94CHUK0.30810243
95PIM20.29784544
96PRKCB0.29450569
97PAK20.29013483
98ABL20.28360378
99RPS6KA10.28282877
100VRK10.27892545

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.54489482
2Vitamin B6 metabolism_Homo sapiens_hsa007504.49373573
3Butanoate metabolism_Homo sapiens_hsa006503.47380320
4Parkinsons disease_Homo sapiens_hsa050123.08705755
5Caffeine metabolism_Homo sapiens_hsa002322.69785728
6Oxidative phosphorylation_Homo sapiens_hsa001902.49040390
7Protein export_Homo sapiens_hsa030602.47690388
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.44322633
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.28525651
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99436015
11Peroxisome_Homo sapiens_hsa041461.94776521
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.83602150
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.82484171
14Chemical carcinogenesis_Homo sapiens_hsa052041.76458610
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68989918
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67770343
17Cardiac muscle contraction_Homo sapiens_hsa042601.66792353
18Circadian rhythm_Homo sapiens_hsa047101.66291985
19Nitrogen metabolism_Homo sapiens_hsa009101.62579926
20Non-homologous end-joining_Homo sapiens_hsa034501.62282255
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58199124
22Huntingtons disease_Homo sapiens_hsa050161.56997828
23Alzheimers disease_Homo sapiens_hsa050101.43437355
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38671504
25Collecting duct acid secretion_Homo sapiens_hsa049661.36503175
26Ribosome_Homo sapiens_hsa030101.33328928
27Primary immunodeficiency_Homo sapiens_hsa053401.32051940
28Tryptophan metabolism_Homo sapiens_hsa003801.12876447
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11859107
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.07855174
31Histidine metabolism_Homo sapiens_hsa003401.07669961
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06668576
33Autoimmune thyroid disease_Homo sapiens_hsa053201.06303555
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04943374
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04839291
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01085658
37Retinol metabolism_Homo sapiens_hsa008300.98666116
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.97982320
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96274928
40Morphine addiction_Homo sapiens_hsa050320.95417443
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91790501
42Glutamatergic synapse_Homo sapiens_hsa047240.91630915
43Axon guidance_Homo sapiens_hsa043600.88685626
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.88506774
45Phagosome_Homo sapiens_hsa041450.86824039
46Regulation of autophagy_Homo sapiens_hsa041400.85219240
47GABAergic synapse_Homo sapiens_hsa047270.84918443
48Taste transduction_Homo sapiens_hsa047420.84294491
49Alcoholism_Homo sapiens_hsa050340.83277099
50Graft-versus-host disease_Homo sapiens_hsa053320.79260498
51ABC transporters_Homo sapiens_hsa020100.77166718
52Systemic lupus erythematosus_Homo sapiens_hsa053220.76314680
53Sulfur relay system_Homo sapiens_hsa041220.75775694
54Hematopoietic cell lineage_Homo sapiens_hsa046400.75568356
55beta-Alanine metabolism_Homo sapiens_hsa004100.74810869
56Steroid biosynthesis_Homo sapiens_hsa001000.74068689
57Starch and sucrose metabolism_Homo sapiens_hsa005000.71008826
58Circadian entrainment_Homo sapiens_hsa047130.70904554
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69374236
60Linoleic acid metabolism_Homo sapiens_hsa005910.69214487
61Calcium signaling pathway_Homo sapiens_hsa040200.63785155
62Serotonergic synapse_Homo sapiens_hsa047260.63606011
63Allograft rejection_Homo sapiens_hsa053300.61912285
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60925483
65Rheumatoid arthritis_Homo sapiens_hsa053230.58939523
66Phototransduction_Homo sapiens_hsa047440.57953692
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56847008
68Tyrosine metabolism_Homo sapiens_hsa003500.56523435
69Nicotine addiction_Homo sapiens_hsa050330.55986410
70Glycerolipid metabolism_Homo sapiens_hsa005610.55949194
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55778410
72Dopaminergic synapse_Homo sapiens_hsa047280.54264504
73Wnt signaling pathway_Homo sapiens_hsa043100.44660831
74Spliceosome_Homo sapiens_hsa030400.42314304
75Endocytosis_Homo sapiens_hsa041440.40601490
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.40554358
77Oocyte meiosis_Homo sapiens_hsa041140.40204292
78Pertussis_Homo sapiens_hsa051330.39739681
79Asthma_Homo sapiens_hsa053100.36475057
80Fatty acid degradation_Homo sapiens_hsa000710.36093421
81Ovarian steroidogenesis_Homo sapiens_hsa049130.35458167
82Proteasome_Homo sapiens_hsa030500.34700754
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34549022
84Type I diabetes mellitus_Homo sapiens_hsa049400.34521353
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33677745
86Phenylalanine metabolism_Homo sapiens_hsa003600.32773479
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31036934
88Hedgehog signaling pathway_Homo sapiens_hsa043400.30814586
89Olfactory transduction_Homo sapiens_hsa047400.30579332
90Antigen processing and presentation_Homo sapiens_hsa046120.30095302
91Cocaine addiction_Homo sapiens_hsa050300.29890926
92Viral myocarditis_Homo sapiens_hsa054160.29637447
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.27498361
94Fat digestion and absorption_Homo sapiens_hsa049750.25892126
95Fatty acid metabolism_Homo sapiens_hsa012120.25625650
96Basal cell carcinoma_Homo sapiens_hsa052170.23018521
97African trypanosomiasis_Homo sapiens_hsa051430.21976066
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21853028
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21805169
100Base excision repair_Homo sapiens_hsa034100.21010183

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