SLC9A3R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)5.58910755
2lymph vessel development (GO:0001945)4.53933359
3vascular endothelial growth factor signaling pathway (GO:0038084)4.50435484
4chemical homeostasis within a tissue (GO:0048875)4.48628411
5lymphangiogenesis (GO:0001946)4.26111600
6glomerular visceral epithelial cell development (GO:0072015)4.23351749
7peptidyl-tyrosine autophosphorylation (GO:0038083)4.05925527
8retina vasculature morphogenesis in camera-type eye (GO:0061299)4.00724626
9renal filtration (GO:0097205)3.97618226
10glomerular epithelial cell development (GO:0072310)3.92087820
11glomerular basement membrane development (GO:0032836)3.89589296
12positive regulation of vasculogenesis (GO:2001214)3.84601617
13glomerular filtration (GO:0003094)3.83980638
14virion attachment to host cell (GO:0019062)3.83456796
15adhesion of symbiont to host cell (GO:0044650)3.83456796
16endothelium development (GO:0003158)3.80617398
17protein localization to endosome (GO:0036010)3.76202091
18regulation of vasculogenesis (GO:2001212)3.70303772
19regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.68450784
20adhesion of symbiont to host (GO:0044406)3.63282036
21blood vessel maturation (GO:0001955)3.61675559
22Golgi transport vesicle coating (GO:0048200)3.54977210
23COPI coating of Golgi vesicle (GO:0048205)3.54977210
24cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.54288804
25regulation of endothelial cell differentiation (GO:0045601)3.50625803
26barbed-end actin filament capping (GO:0051016)3.43828656
27regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.39973550
28protein retention in ER lumen (GO:0006621)3.30141432
29endothelial cell morphogenesis (GO:0001886)3.28599258
30protein carboxylation (GO:0018214)3.23662867
31peptidyl-glutamic acid carboxylation (GO:0017187)3.23662867
32negative regulation of cell size (GO:0045792)3.23613191
33NADH metabolic process (GO:0006734)3.22432388
34heart trabecula formation (GO:0060347)3.19684007
35adherens junction assembly (GO:0034333)3.18252193
36endothelial cell differentiation (GO:0045446)3.17366829
37axon ensheathment in central nervous system (GO:0032291)3.14348692
38central nervous system myelination (GO:0022010)3.14348692
39semaphorin-plexin signaling pathway (GO:0071526)3.12844632
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.12545614
41L-phenylalanine metabolic process (GO:0006558)3.12545614
42ethanol metabolic process (GO:0006067)3.11673534
43ethanol oxidation (GO:0006069)3.11577126
44protein maturation by protein folding (GO:0022417)3.08324332
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.07351926
46plasma membrane repair (GO:0001778)3.05033924
47negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.04222670
48bundle of His cell to Purkinje myocyte communication (GO:0086069)3.03310073
49vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.02114499
50creatine metabolic process (GO:0006600)2.99279333
51focal adhesion assembly (GO:0048041)2.98587422
52cell-substrate adherens junction assembly (GO:0007045)2.98587422
53negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94676514
54axon ensheathment (GO:0008366)2.93767661
55ensheathment of neurons (GO:0007272)2.93767661
56cell migration involved in sprouting angiogenesis (GO:0002042)2.93704649
57regulation of plasminogen activation (GO:0010755)2.91410056
58extracellular fibril organization (GO:0043206)2.90506137
59epithelial cell-cell adhesion (GO:0090136)2.90091380
60sarcomere organization (GO:0045214)2.88479119
61myelination (GO:0042552)2.88321042
62primary alcohol catabolic process (GO:0034310)2.87627038
63cell-substrate junction assembly (GO:0007044)2.84507724
64atrioventricular valve morphogenesis (GO:0003181)2.84377150
65type B pancreatic cell proliferation (GO:0044342)2.84257744
66cardiac myofibril assembly (GO:0055003)2.81749502
67venous blood vessel morphogenesis (GO:0048845)2.80803071
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.80555628
69basement membrane organization (GO:0071711)2.79534612
70desmosome organization (GO:0002934)2.79044412
71negative regulation of protein localization to cell surface (GO:2000009)2.78068695
72regulation of cardioblast differentiation (GO:0051890)2.77084690
73endothelial tube morphogenesis (GO:0061154)2.75810431
74morphogenesis of an endothelium (GO:0003159)2.75810431
75positive regulation of lipoprotein lipase activity (GO:0051006)2.73735034
76positive regulation of triglyceride lipase activity (GO:0061365)2.73735034
77skin morphogenesis (GO:0043589)2.73181460
78negative regulation of potassium ion transmembrane transport (GO:1901380)2.73086070
79muscle cell migration (GO:0014812)2.71882740
80retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.71584533
81regulation of p38MAPK cascade (GO:1900744)2.70209519
82protein heterotrimerization (GO:0070208)2.68789701
83regulation of glucose import in response to insulin stimulus (GO:2001273)2.68162189
84cell volume homeostasis (GO:0006884)2.67659353
85regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.64487536
86regulation of axon extension involved in axon guidance (GO:0048841)2.64113791
87fibrinolysis (GO:0042730)2.63229623
88endothelial cell chemotaxis (GO:0035767)2.63210574
89regulation of actin filament-based movement (GO:1903115)2.62841532
90positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62781495
91negative regulation of Rho protein signal transduction (GO:0035024)2.61760706
92negative regulation of fatty acid transport (GO:2000192)2.61603275
93protein targeting to plasma membrane (GO:0072661)2.61239706
94negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.61214342
95transcytosis (GO:0045056)2.59937489
96myofibril assembly (GO:0030239)2.54929649
97regulation of cell communication by electrical coupling (GO:0010649)2.53426319
98dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52131968
99regulation of axon guidance (GO:1902667)2.51341026
100proline biosynthetic process (GO:0006561)2.50890164
101positive regulation of receptor recycling (GO:0001921)2.50279229
102positive regulation of endothelial cell differentiation (GO:0045603)2.49265329
103fibril organization (GO:0097435)2.48626879
104blood vessel endothelial cell migration (GO:0043534)2.48538780
105ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.47625092
106L-phenylalanine catabolic process (GO:0006559)2.47570123
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.47570123
108actin filament depolymerization (GO:0030042)2.47012745
109planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46623103
110regulation of extracellular matrix disassembly (GO:0010715)2.46240792
111complement activation, alternative pathway (GO:0006957)2.46168751
112negative regulation of fibrinolysis (GO:0051918)2.45600262
113patterning of blood vessels (GO:0001569)2.43043478
114regulation of cardiac muscle cell contraction (GO:0086004)2.38363099
115maternal placenta development (GO:0001893)2.38224988
116cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.37922538
117coronary vasculature morphogenesis (GO:0060977)2.37353126
118proline metabolic process (GO:0006560)2.36900247
119regulation of glomerular filtration (GO:0003093)2.36774602
120insulin-like growth factor receptor signaling pathway (GO:0048009)2.35980433
121artery development (GO:0060840)2.35024416
122regulation of complement activation (GO:0030449)2.35018776
123regulation of protein activation cascade (GO:2000257)2.34790138
124regulation of fibrinolysis (GO:0051917)2.34109349
125fatty acid elongation (GO:0030497)2.32948256
126neuron remodeling (GO:0016322)2.31758832
127cell-cell junction maintenance (GO:0045217)2.31017416
128hemidesmosome assembly (GO:0031581)2.30278509
129cell communication involved in cardiac conduction (GO:0086065)2.29994284
130branching involved in salivary gland morphogenesis (GO:0060445)2.29421209
131myelin maintenance (GO:0043217)2.28407595
132regulation of vascular permeability (GO:0043114)2.28344689
133trabecula formation (GO:0060343)2.28314156
134positive regulation of extracellular matrix organization (GO:1903055)2.27913273
135regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.27579682
136regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.27366462
137positive regulation of p38MAPK cascade (GO:1900745)2.27214674
138endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.26840954
139positive regulation of endothelial cell migration (GO:0010595)2.26158716
140cell migration involved in heart development (GO:0060973)2.25912520
141triglyceride catabolic process (GO:0019433)2.25462604
142actomyosin structure organization (GO:0031032)2.25372614
143cell adhesion mediated by integrin (GO:0033627)2.25308190
144apoptotic process involved in morphogenesis (GO:0060561)2.25266023
145regulation of mammary gland epithelial cell proliferation (GO:0033599)2.24181913
146epoxygenase P450 pathway (GO:0019373)2.23895817
147regulation of relaxation of muscle (GO:1901077)2.23509486
148response to water (GO:0009415)2.23080304
149cardiac muscle tissue morphogenesis (GO:0055008)2.22994113
150synaptic vesicle docking involved in exocytosis (GO:0016081)2.22743140
151stress fiber assembly (GO:0043149)2.22695533
152positive regulation of endothelial cell apoptotic process (GO:2000353)2.22421483
153potassium ion import (GO:0010107)2.22401994
154platelet-derived growth factor receptor signaling pathway (GO:0048008)2.22380312
155urea metabolic process (GO:0019627)2.22187451
156fatty acid transmembrane transport (GO:1902001)2.22155988
157response to mercury ion (GO:0046689)2.21073043
158endocardial cushion development (GO:0003197)2.20936889
159positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.20430971
160myelination in peripheral nervous system (GO:0022011)2.19867423
161peripheral nervous system axon ensheathment (GO:0032292)2.19867423
162acylglycerol catabolic process (GO:0046464)2.19807987
163neutral lipid catabolic process (GO:0046461)2.19807987
164negative regulation of blood coagulation (GO:0030195)2.19797845
165negative regulation of hemostasis (GO:1900047)2.19797845
166regulation of blood vessel endothelial cell migration (GO:0043535)2.19736840
167metanephric epithelium development (GO:0072207)2.19396832
168interleukin-6-mediated signaling pathway (GO:0070102)2.19214587
169cellular response to epinephrine stimulus (GO:0071872)2.19136904
170negative regulation of blood vessel endothelial cell migration (GO:0043537)2.18683678
171apoptotic cell clearance (GO:0043277)2.18650502
172regulation of cholesterol biosynthetic process (GO:0045540)2.18484876
173camera-type eye morphogenesis (GO:0048593)2.17816463
174vasculogenesis (GO:0001570)2.17653955
175renal system process involved in regulation of blood volume (GO:0001977)2.17237537
176membrane assembly (GO:0071709)2.17163819
1774-hydroxyproline metabolic process (GO:0019471)2.16678971
178blood vessel remodeling (GO:0001974)2.15647102
179regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.14856595
180metanephric nephron epithelium development (GO:0072243)2.14675001
181negative regulation of axon extension involved in axon guidance (GO:0048843)2.14560024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.40123094
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.26849972
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.26813078
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.26673449
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45401289
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.41613657
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.26468329
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12642017
9GATA2_21666600_ChIP-Seq_HMVEC_Human2.08877853
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07448081
11* CLOCK_20551151_ChIP-Seq_293T_Human1.97905028
12RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94218148
13EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94218148
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88215620
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88109378
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85118453
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.83124632
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81069472
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.80798733
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77774396
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.76473148
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.75448317
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74298808
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72520309
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71448318
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.68729402
27TBX20_22328084_ChIP-Seq_HEART_Mouse1.68729402
28UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66676735
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.65780344
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63597245
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.61068244
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60993495
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57923555
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57277697
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56883689
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56502634
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55728205
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53506967
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53476432
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53389777
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53139681
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52918395
43* P68_20966046_ChIP-Seq_HELA_Human1.48686990
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48449782
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48389770
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47972763
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.46053152
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45401237
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.45213418
50DROSHA_22980978_ChIP-Seq_HELA_Human1.42771179
51SMC4_20622854_ChIP-Seq_HELA_Human1.41800760
52ZNF263_19887448_ChIP-Seq_K562_Human1.41190779
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.40807313
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.39603358
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38534285
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37717809
57* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37293257
58KDM2B_26808549_Chip-Seq_DND41_Human1.36830572
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36382855
60* RUNX1_27514584_Chip-Seq_MCF-7_Human1.34915354
61KDM2B_26808549_Chip-Seq_K562_Human1.34461964
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33885835
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33786263
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33659385
65* CREB1_26743006_Chip-Seq_LNCaP_Human1.32233329
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31728325
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31331067
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.31187238
69ATF3_27146783_Chip-Seq_COLON_Human1.29980631
70* SA1_27219007_Chip-Seq_ERYTHROID_Human1.29664646
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.29511832
72* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28861352
73TCF7_22412390_ChIP-Seq_EML_Mouse1.28801846
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28425687
75AHR_22903824_ChIP-Seq_MCF-7_Human1.28257637
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28095239
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28018867
78* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25971458
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24867140
80VDR_21846776_ChIP-Seq_THP-1_Human1.24728513
81SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23755472
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.23082126
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.18845868
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18253875
85GATA1_19941826_ChIP-Seq_K562_Human1.17279596
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17116978
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.16626036
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16543313
89TP53_22127205_ChIP-Seq_IMR90_Human1.16261439
90SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15918417
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13982592
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13623912
93SOX2_20726797_ChIP-Seq_SW620_Human1.12085990
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12049907
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11741421
96CJUN_26792858_Chip-Seq_BT549_Human1.11239333
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10033657
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09347328
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.08617090
100LXR_22292898_ChIP-Seq_THP-1_Human1.06454962
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06045106
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.05838277
103TP63_22573176_ChIP-Seq_HFKS_Human1.05489177
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05353511
105RACK7_27058665_Chip-Seq_MCF-7_Human1.04623282
106STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03563373
107SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02865102
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01831338
109* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01612120
110TP53_20018659_ChIP-ChIP_R1E_Mouse1.01058263
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.01032153
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00463550
113* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00107771
114TP53_23651856_ChIP-Seq_MEFs_Mouse1.00029731
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99301116
116* CTCF_27219007_Chip-Seq_Bcells_Human0.99086252
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98726069
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.98522497
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98298632
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98267135
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97732597
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.97134096
123ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95347810
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.95140342
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94409317
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.94390242
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94259212
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94198680
129* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94152928
130* FOXA2_19822575_ChIP-Seq_HepG2_Human0.93522120
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93033304
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93027595
133BP1_19119308_ChIP-ChIP_Hs578T_Human0.92996648
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92351117
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91569509
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91125614
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91125614
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90797103
139ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90260583
140PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88154083
141* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87955324
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87170205
143CDX2_20551321_ChIP-Seq_CACO-2_Human0.87016032
144GATA1_22025678_ChIP-Seq_K562_Human0.86842993
145P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86638774
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86346705
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85988421
148RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85875131
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85760218
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85753851
151GBX2_23144817_ChIP-Seq_PC3_Human0.85573765
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.85507074
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.84288391
154EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83288741
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82985822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.03982509
2MP0001879_abnormal_lymphatic_vessel4.05426753
3MP0005167_abnormal_blood-brain_barrier3.81188802
4MP0004084_abnormal_cardiac_muscle3.77442173
5MP0004272_abnormal_basement_membrane3.63105940
6MP0004036_abnormal_muscle_relaxation2.91008777
7MP0002837_dystrophic_cardiac_calcinosis2.74401801
8MP0000751_myopathy2.54352851
9MP0001958_emphysema2.51465545
10MP0006138_congestive_heart_failure2.41958754
11MP0010030_abnormal_orbit_morphology2.18862852
12MP0004215_abnormal_myocardial_fiber2.18136328
13MP0005623_abnormal_meninges_morphology2.13778278
14MP0005330_cardiomyopathy2.11979941
15MP0005503_abnormal_tendon_morphology2.09928726
16MP0008775_abnormal_heart_ventricle1.99905896
17MP0003950_abnormal_plasma_membrane1.99212575
18MP0003828_pulmonary_edema1.92571619
19MP0005360_urolithiasis1.88577973
20MP0005385_cardiovascular_system_phenoty1.82641323
21MP0001544_abnormal_cardiovascular_syste1.82641323
22MP0005257_abnormal_intraocular_pressure1.82070570
23MP0002972_abnormal_cardiac_muscle1.79790350
24MP0000749_muscle_degeneration1.76811195
25MP0009840_abnormal_foam_cell1.74872166
26MP0000920_abnormal_myelination1.73739567
27MP0004085_abnormal_heartbeat1.71860727
28MP0002295_abnormal_pulmonary_circulatio1.71077683
29MP0008438_abnormal_cutaneous_collagen1.66504842
30MP0004130_abnormal_muscle_cell1.65601223
31MP0003279_aneurysm1.63050719
32MP0004484_altered_response_of1.62121637
33MP0005165_increased_susceptibility_to1.61431543
34MP0004087_abnormal_muscle_fiber1.58643173
35MP0002249_abnormal_larynx_morphology1.55652453
36MP0002138_abnormal_hepatobiliary_system1.55041822
37MP0000767_abnormal_smooth_muscle1.54520602
38MP0005620_abnormal_muscle_contractility1.53180679
39MP0001849_ear_inflammation1.52616560
40MP0002877_abnormal_melanocyte_morpholog1.50285914
41MP0010630_abnormal_cardiac_muscle1.49334167
42MP0005451_abnormal_body_composition1.46285809
43MP0004510_myositis1.44136769
44MP0002796_impaired_skin_barrier1.42673755
45MP0004147_increased_porphyrin_level1.41718687
46MP0000747_muscle_weakness1.41540355
47MP0005058_abnormal_lysosome_morphology1.38582476
48MP0005595_abnormal_vascular_smooth1.37478854
49MP0005083_abnormal_biliary_tract1.36377964
50MP0000230_abnormal_systemic_arterial1.34826865
51MP0003137_abnormal_impulse_conducting1.34374364
52MP0010234_abnormal_vibrissa_follicle1.31184437
53MP0000343_altered_response_to1.26397486
54MP0000013_abnormal_adipose_tissue1.26347367
55MP0004782_abnormal_surfactant_physiolog1.26255959
56MP0004145_abnormal_muscle_electrophysio1.23287299
57MP0005023_abnormal_wound_healing1.23098295
58MP0003724_increased_susceptibility_to1.22038535
59MP0004185_abnormal_adipocyte_glucose1.21387636
60MP0000678_abnormal_parathyroid_gland1.20778896
61MP0000537_abnormal_urethra_morphology1.18748643
62MP0000750_abnormal_muscle_regeneration1.18503306
63MP0002060_abnormal_skin_morphology1.17558920
64MP0003690_abnormal_glial_cell1.17326623
65MP0000733_abnormal_muscle_development1.15888404
66MP0002896_abnormal_bone_mineralization1.15787220
67MP0002332_abnormal_exercise_endurance1.15713470
68MP0002128_abnormal_blood_circulation1.13982663
69MP0001542_abnormal_bone_strength1.13343142
70MP0005666_abnormal_adipose_tissue1.10167740
71MP0002139_abnormal_hepatobiliary_system1.09881781
72MP0002127_abnormal_cardiovascular_syste1.06551576
73MP0000249_abnormal_blood_vessel1.06448945
74MP0003705_abnormal_hypodermis_morpholog1.06233140
75MP0004885_abnormal_endolymph1.05658654
76MP0000534_abnormal_ureter_morphology1.04386965
77MP0005508_abnormal_skeleton_morphology1.03972713
78MP0002133_abnormal_respiratory_system1.02804187
79MP0005388_respiratory_system_phenotype1.02804187
80MP0000467_abnormal_esophagus_morphology1.01803079
81MP0004270_analgesia1.00153549
82MP0002269_muscular_atrophy0.99931245
83MP0005501_abnormal_skin_physiology0.99678435
84MP0003329_amyloid_beta_deposits0.98434172
85MP0003646_muscle_fatigue0.98183389
86MP0004043_abnormal_pH_regulation0.97286104
87MP0003566_abnormal_cell_adhesion0.97263575
88MP0000759_abnormal_skeletal_muscle0.95329110
89MP0000762_abnormal_tongue_morphology0.94946172
90MP0002106_abnormal_muscle_physiology0.94704466
91MP0005670_abnormal_white_adipose0.94362229
92MP0005332_abnormal_amino_acid0.93426394
93MP0009053_abnormal_anal_canal0.93261345
94MP0001614_abnormal_blood_vessel0.93105357
95MP0005365_abnormal_bile_salt0.93063702
96MP0002971_abnormal_brown_adipose0.92866701
97MP0002925_abnormal_cardiovascular_devel0.91382466
98MP0003191_abnormal_cellular_cholesterol0.91332017
99MP0005076_abnormal_cell_differentiation0.90912218
100MP0005375_adipose_tissue_phenotype0.90109239
101MP0003091_abnormal_cell_migration0.89750267
102MP0003453_abnormal_keratinocyte_physiol0.88878500
103MP0001756_abnormal_urination0.88376088
104MP0005164_abnormal_response_to0.87772212
105MP0005369_muscle_phenotype0.87691672
106MP0004233_abnormal_muscle_weight0.86397220
107MP0003634_abnormal_glial_cell0.85595032
108MP0009643_abnormal_urine_homeostasis0.85278123
109MP0002933_joint_inflammation0.81925392
110MP0000266_abnormal_heart_morphology0.80324908
111MP0003879_abnormal_hair_cell0.79489247
112MP0001661_extended_life_span0.78836432
113MP0002089_abnormal_postnatal_growth/wei0.78258357
114MP0008004_abnormal_stomach_pH0.78113752
115MP0003942_abnormal_urinary_system0.78017084
116MP0008875_abnormal_xenobiotic_pharmacok0.77545814
117MP0009384_cardiac_valve_regurgitation0.77013290
118MP0000858_altered_metastatic_potential0.76987429
119MP0000566_synostosis0.76034160
120MP0010329_abnormal_lipoprotein_level0.75185306
121MP0003221_abnormal_cardiomyocyte_apopto0.74780372
122MP0004883_abnormal_blood_vessel0.74735703
123MP0006054_spinal_hemorrhage0.74372774
124MP0005275_abnormal_skin_tensile0.72005303
125MP0002108_abnormal_muscle_morphology0.71676785
126MP0000003_abnormal_adipose_tissue0.71302381
127MP0002932_abnormal_joint_morphology0.70342185
128MP0001348_abnormal_lacrimal_gland0.69570761
129MP0003045_fibrosis0.69441416
130MP0000462_abnormal_digestive_system0.69074209
131MP0002970_abnormal_white_adipose0.69057207
132MP0009780_abnormal_chondrocyte_physiolo0.67842245
133MP0005409_darkened_coat_color0.66570705
134MP0003633_abnormal_nervous_system0.66552905
135MP0002118_abnormal_lipid_homeostasis0.63316778
136MP0001784_abnormal_fluid_regulation0.63198778
137MP0003075_altered_response_to0.62233123
138MP0005171_absent_coat_pigmentation0.61709830
139MP0004858_abnormal_nervous_system0.60137191

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.67556213
2Polycythemia (HP:0001901)4.44915391
3Muscle fiber splitting (HP:0003555)4.39020537
4Distal lower limb muscle weakness (HP:0009053)4.23783630
5Hyporeflexia of lower limbs (HP:0002600)4.21161591
6Cerebral hemorrhage (HP:0001342)4.12196225
7Broad metatarsal (HP:0001783)4.08619847
8Sudden death (HP:0001699)4.05578725
9Distal lower limb amyotrophy (HP:0008944)3.29560662
10Ventricular tachycardia (HP:0004756)3.27214348
11Hematochezia (HP:0002573)3.17663964
12Type 1 muscle fiber predominance (HP:0003803)3.17326205
13Mildly elevated creatine phosphokinase (HP:0008180)3.14326440
14Hyperactive renin-angiotensin system (HP:0000841)3.13952697
15Hypokalemic alkalosis (HP:0001949)3.12386704
16Mesangial abnormality (HP:0001966)3.11083528
17Visceral angiomatosis (HP:0100761)3.10407547
18Atrial fibrillation (HP:0005110)3.07410499
19Difficulty running (HP:0009046)3.03912800
20Vertebral compression fractures (HP:0002953)2.98757098
21Spontaneous hematomas (HP:0007420)2.96659734
22Focal segmental glomerulosclerosis (HP:0000097)2.93685915
23Deep venous thrombosis (HP:0002625)2.87812352
24Exercise-induced myalgia (HP:0003738)2.87617208
25Hemangiomatosis (HP:0007461)2.82825954
26Neurofibrillary tangles (HP:0002185)2.82394066
27Right ventricular cardiomyopathy (HP:0011663)2.81664438
28Increased connective tissue (HP:0009025)2.81650809
29Abnormality of complement system (HP:0005339)2.80952442
30Lymphangioma (HP:0100764)2.80503302
31Calf muscle hypertrophy (HP:0008981)2.80189784
32Primary atrial arrhythmia (HP:0001692)2.80026051
33Exercise-induced muscle cramps (HP:0003710)2.79319010
34Upper limb amyotrophy (HP:0009129)2.79265301
35Distal upper limb amyotrophy (HP:0007149)2.79265301
36Vascular tortuosity (HP:0004948)2.77868554
37Renal salt wasting (HP:0000127)2.77200076
38Obstructive sleep apnea (HP:0002870)2.76659494
39Hemorrhage of the eye (HP:0011885)2.76574895
40Supraventricular arrhythmia (HP:0005115)2.75824556
41Cervical subluxation (HP:0003308)2.75726253
42Increased circulating renin level (HP:0000848)2.75034434
43Esophageal varix (HP:0002040)2.74237890
44Muscle hypertrophy of the lower extremities (HP:0008968)2.74050352
45Achilles tendon contracture (HP:0001771)2.72777359
46Abnormality of the Achilles tendon (HP:0005109)2.71088368
47Glomerulosclerosis (HP:0000096)2.70723816
48Increased variability in muscle fiber diameter (HP:0003557)2.70170055
49EMG: myopathic abnormalities (HP:0003458)2.64726662
50Supraventricular tachycardia (HP:0004755)2.64127197
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63534311
52Fragile skin (HP:0001030)2.63299926
53Complement deficiency (HP:0004431)2.63137886
54Arterial tortuosity (HP:0005116)2.61109657
55Rapidly progressive (HP:0003678)2.60159863
56Myotonia (HP:0002486)2.59676809
57Prolonged QT interval (HP:0001657)2.56021452
58Short nail (HP:0001799)2.55501406
59J-shaped sella turcica (HP:0002680)2.53707466
60Aortic aneurysm (HP:0004942)2.53367092
61Broad face (HP:0000283)2.49847739
62Syncope (HP:0001279)2.47708199
63Acanthosis nigricans (HP:0000956)2.46991108
64Cerebral aneurysm (HP:0004944)2.42294745
65Interstitial pulmonary disease (HP:0006530)2.41952555
66Abnormality of the calf musculature (HP:0001430)2.39486083
67Pulmonary artery stenosis (HP:0004415)2.38182791
68Hypomagnesemia (HP:0002917)2.37174376
69Lipoatrophy (HP:0100578)2.35227809
70Axonal loss (HP:0003447)2.33557777
71Abnormality of renin-angiotensin system (HP:0000847)2.32094186
72Cavernous hemangioma (HP:0001048)2.31499443
73Hyperacusis (HP:0010780)2.31132099
74Facial shape deformation (HP:0011334)2.29949282
75Potter facies (HP:0002009)2.29949282
76Myoglobinuria (HP:0002913)2.29460799
77Hyperaldosteronism (HP:0000859)2.29283052
78Vascular calcification (HP:0004934)2.28034021
79Cardiovascular calcification (HP:0011915)2.27941186
80Lower limb amyotrophy (HP:0007210)2.27851592
81Muscle stiffness (HP:0003552)2.26738440
82Atrophic scars (HP:0001075)2.26570024
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25365236
84Aortic dissection (HP:0002647)2.25271823
85Abnormality of skeletal muscle fiber size (HP:0012084)2.25173169
86Ulnar bowing (HP:0003031)2.21724675
87Wormian bones (HP:0002645)2.20859825
88Dilated cardiomyopathy (HP:0001644)2.20539948
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.19927114
90Blue sclerae (HP:0000592)2.19627423
91Generalized amyotrophy (HP:0003700)2.17672460
92Ankle contracture (HP:0006466)2.17373924
93Sensory axonal neuropathy (HP:0003390)2.16346149
94Joint stiffness (HP:0001387)2.15692374
95Cerebral inclusion bodies (HP:0100314)2.13199400
96Nonimmune hydrops fetalis (HP:0001790)2.12099005
97Foot dorsiflexor weakness (HP:0009027)2.12087826
98Back pain (HP:0003418)2.11181396
99Mitral stenosis (HP:0001718)2.10826391
100Mitral regurgitation (HP:0001653)2.10819092
101Hyperkalemia (HP:0002153)2.10035337
102Abnormality of chloride homeostasis (HP:0011422)2.08044713
103Spinal cord compression (HP:0002176)2.07913023
104Reduced subcutaneous adipose tissue (HP:0003758)2.06160792
105Joint hemorrhage (HP:0005261)2.06153635
106Abnormality of magnesium homeostasis (HP:0004921)2.05580176
107Nuclear cataract (HP:0100018)2.05546329
108Growth hormone excess (HP:0000845)2.05458761
109Onion bulb formation (HP:0003383)2.04838346
110Bladder diverticulum (HP:0000015)2.04688671
111Neck muscle weakness (HP:0000467)2.04300846
112Glucose intolerance (HP:0000833)2.04129347
113Abnormality of the distal phalanges of the toes (HP:0010182)2.03627790
114Gout (HP:0001997)2.03370255
115Ventricular fibrillation (HP:0001663)2.03284792
116Pheochromocytoma (HP:0002666)2.02449342
117Abnormality of the nasal mucosa (HP:0000433)2.02190275
118Bundle branch block (HP:0011710)2.01928039
119Myopathic facies (HP:0002058)2.00611365
120Osteolytic defects of the hand bones (HP:0009699)1.99330086
121Osteolytic defects of the phalanges of the hand (HP:0009771)1.99330086
122Palpitations (HP:0001962)1.99041253
123Hypoplasia of the iris (HP:0007676)1.98694123
124Bulbar palsy (HP:0001283)1.98457727
125Supranuclear gaze palsy (HP:0000605)1.95286416
126Venous abnormality (HP:0002624)1.95026984
127Abnormality of the foot musculature (HP:0001436)1.94313215
128Xanthomatosis (HP:0000991)1.93514267
129Shallow orbits (HP:0000586)1.93436477
130Long toe (HP:0010511)1.92943661
131Bronchomalacia (HP:0002780)1.91843668
132Difficulty climbing stairs (HP:0003551)1.91809913
133Biconcave vertebral bodies (HP:0004586)1.91073834
134Short hallux (HP:0010109)1.90079250
135Thin bony cortex (HP:0002753)1.88522744
136Atelectasis (HP:0100750)1.87623075
137Hand muscle atrophy (HP:0009130)1.87021349
138Ventricular arrhythmia (HP:0004308)1.85698671
139Hypoplastic left heart (HP:0004383)1.85409562
140Coxa vara (HP:0002812)1.84497249
141Respiratory distress (HP:0002098)1.83864349
142Aplasia/Hypoplasia of the hallux (HP:0008362)1.83624842
143Hypertriglyceridemia (HP:0002155)1.81671933
144Elbow flexion contracture (HP:0002987)1.81637349
145Conjunctival telangiectasia (HP:0000524)1.81299135
146Atrioventricular block (HP:0001678)1.81153137
147Round ear (HP:0100830)1.81022548
148Tachypnea (HP:0002789)1.80998239
149Premature rupture of membranes (HP:0001788)1.80013623
150Heart block (HP:0012722)1.79660944
151Spinal rigidity (HP:0003306)1.79545827
152Systemic lupus erythematosus (HP:0002725)1.79217010
153Asymmetric septal hypertrophy (HP:0001670)1.77792706
154Ketoacidosis (HP:0001993)1.77743161
155Tubulointerstitial fibrosis (HP:0005576)1.76621872
156Flat acetabular roof (HP:0003180)1.76229956
157Aneurysm (HP:0002617)1.75142122
158Stridor (HP:0010307)1.74930088
159Testicular atrophy (HP:0000029)1.74151878
160Abnormality of dentin (HP:0010299)1.74002223
161Abnormal atrioventricular conduction (HP:0005150)1.73668096
162Insulin resistance (HP:0000855)1.71900220
163Skin nodule (HP:0200036)1.71211591
164Asymmetry of the thorax (HP:0001555)1.70167674
165Metabolic alkalosis (HP:0200114)1.68784479
166Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67260035
167Degeneration of the lateral corticospinal tracts (HP:0002314)1.67260035
168Scapular winging (HP:0003691)1.63887842
169Ulnar claw (HP:0001178)1.63846358
170Stage 5 chronic kidney disease (HP:0003774)1.62752612
171Nephritis (HP:0000123)1.61580333
172Adactyly (HP:0009776)1.60125685
173Neuroendocrine neoplasm (HP:0100634)1.58494078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.15585734
2EPHA24.28420460
3STK394.27849756
4WNK43.55279158
5KDR3.43850804
6TESK13.28442991
7OXSR13.23921561
8MST1R2.62999447
9TGFBR22.48058805
10EPHB22.32272575
11EPHB12.23964332
12MYLK2.22364557
13IRAK32.07894285
14TTN2.00984193
15MAPKAPK31.87474920
16PHKG11.85889734
17PHKG21.85889734
18SMG11.78255313
19LMTK21.61927624
20FGFR21.61168814
21MET1.58275114
22ARAF1.56240624
23NME21.55944495
24WNK11.52108738
25RIPK11.50077840
26ICK1.42876272
27TRIB31.42858111
28PTK2B1.37442340
29BCR1.35274357
30EEF2K1.33067588
31ERN11.31789021
32NTRK11.27549928
33FER1.26384247
34DMPK1.25175225
35GRK11.24413509
36BCKDK1.23645289
37TESK21.18149416
38PRKD11.13715977
39KSR21.12015168
40PDGFRA1.10555521
41PAK61.10383015
42PDK21.09879827
43PRKD21.07819501
44PAK31.04284485
45RPS6KA21.00785051
46ROCK20.98633803
47PINK10.97672311
48LIMK10.97521580
49PTK60.92199310
50MAP3K30.88335297
51TAOK20.86831593
52STK380.85663332
53PDPK10.85112890
54TGFBR10.84227346
55CDK190.83493580
56MUSK0.83399196
57LRRK20.82465023
58ABL20.81490403
59PRKCH0.80687322
60CDC42BPA0.79798076
61MAP3K60.77861499
62MTOR0.77852640
63CAMK1G0.76896869
64RPS6KB20.76228502
65PKN10.75202170
66PAK40.74607626
67SCYL20.74299495
68PTK20.73996305
69ROCK10.73734509
70CAMK2D0.70796233
71OBSCN0.70731503
72PDGFRB0.67759334
73MAPK150.66905517
74TBK10.65331548
75PIM20.64898011
76RET0.64356756
77MAPK120.63997019
78PIK3CA0.63764505
79PKN20.61697615
80MARK20.61553701
81PRKG20.60587019
82HIPK20.59153478
83MAP3K10.58853826
84MOS0.58739598
85MAP2K20.58063578
86ILK0.58016845
87MAP3K20.57698836
88LATS20.57676916
89PDK40.57249172
90PDK30.57249172
91DDR20.56927487
92MAP3K90.56910209
93RPS6KL10.56895655
94RPS6KC10.56895655
95CSNK1A1L0.56495993
96MAP3K70.56448564
97CAMK2B0.55577782
98TYRO30.54468426
99FGFR40.54092997
100MAP3K120.53235643
101BMX0.52959142
102AKT20.52834269
103PRKCE0.51310777
104MAP2K10.50714252
105CAMK1D0.50295190
106CSNK1G30.50156262
107BRAF0.48844099
108PRKD30.47355681
109CAMK2G0.46800493
110GSK3A0.46680220
111DAPK30.46585496
112DAPK10.46257957
113DAPK20.46156374
114PRKAA20.45898257
115GRK50.45691498
116ERBB40.45077523
117PRKCI0.44782315
118FGR0.42755064
119EPHA30.42445825
120UHMK10.40706134
121CSNK1G20.40193887
122PAK20.40171636
123MAP2K30.39666406
124MAP3K110.39103230
125CSNK1G10.38809534
126RPS6KA60.38537336
127CSK0.38388182
128CAMK2A0.38288850
129PAK10.37718883
130PRPF4B0.37269955
131CDK50.36898034
132TRPM70.36349577
133INSRR0.36034588
134SRC0.34841541
135MAPKAPK20.34755696
136MAP3K130.34576151
137CDK140.34067916
138MAPK40.33749393
139SIK10.33693399
140IRAK20.32262196
141VRK20.31690150
142CDK80.31527975

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003602.89585877
2Dilated cardiomyopathy_Homo sapiens_hsa054142.05217514
3Tyrosine metabolism_Homo sapiens_hsa003502.04514286
4Fatty acid elongation_Homo sapiens_hsa000622.01625117
5ECM-receptor interaction_Homo sapiens_hsa045121.99166533
6Cyanoamino acid metabolism_Homo sapiens_hsa004601.98335498
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96091939
8Propanoate metabolism_Homo sapiens_hsa006401.95956544
9Sulfur relay system_Homo sapiens_hsa041221.92820406
10Cardiac muscle contraction_Homo sapiens_hsa042601.87904765
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.84425945
12Prion diseases_Homo sapiens_hsa050201.84160189
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77387384
14Fatty acid degradation_Homo sapiens_hsa000711.77233079
15Histidine metabolism_Homo sapiens_hsa003401.74606898
16Fatty acid metabolism_Homo sapiens_hsa012121.71791806
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.71523079
18Focal adhesion_Homo sapiens_hsa045101.60348022
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58093962
20Axon guidance_Homo sapiens_hsa043601.55434425
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54947548
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53515000
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51780087
24Fructose and mannose metabolism_Homo sapiens_hsa000511.47973870
25Tight junction_Homo sapiens_hsa045301.44140029
26Biosynthesis of amino acids_Homo sapiens_hsa012301.40289156
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34041339
28Pentose phosphate pathway_Homo sapiens_hsa000301.32428146
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31689781
30Oxidative phosphorylation_Homo sapiens_hsa001901.30575584
31Butanoate metabolism_Homo sapiens_hsa006501.28088851
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26683156
33Renal cell carcinoma_Homo sapiens_hsa052111.24288562
34Dorso-ventral axis formation_Homo sapiens_hsa043201.21192759
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.20166148
36AMPK signaling pathway_Homo sapiens_hsa041521.18060004
37Bile secretion_Homo sapiens_hsa049761.17856487
38Other glycan degradation_Homo sapiens_hsa005111.17476120
39Protein digestion and absorption_Homo sapiens_hsa049741.16255523
40Parkinsons disease_Homo sapiens_hsa050121.14790825
41Chemical carcinogenesis_Homo sapiens_hsa052041.14561913
42PPAR signaling pathway_Homo sapiens_hsa033201.14365250
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13751936
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13464954
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10187684
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10092423
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09785309
48Alzheimers disease_Homo sapiens_hsa050101.05556144
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05407689
50Insulin signaling pathway_Homo sapiens_hsa049101.03011612
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01362766
52Pyruvate metabolism_Homo sapiens_hsa006201.00270583
53Rap1 signaling pathway_Homo sapiens_hsa040150.99324270
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.98238133
55Galactose metabolism_Homo sapiens_hsa000520.97837178
56* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96521631
57Pancreatic secretion_Homo sapiens_hsa049720.95854910
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.95260534
59Gastric acid secretion_Homo sapiens_hsa049710.94712767
60Arginine and proline metabolism_Homo sapiens_hsa003300.94203359
61Retinol metabolism_Homo sapiens_hsa008300.93980007
62Vitamin B6 metabolism_Homo sapiens_hsa007500.93265171
63Arginine biosynthesis_Homo sapiens_hsa002200.92211595
64Tryptophan metabolism_Homo sapiens_hsa003800.91894203
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91325357
66Glucagon signaling pathway_Homo sapiens_hsa049220.91210312
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90604112
68Fatty acid biosynthesis_Homo sapiens_hsa000610.90249262
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90248321
70Renin secretion_Homo sapiens_hsa049240.89526878
71Amoebiasis_Homo sapiens_hsa051460.89384812
72Gap junction_Homo sapiens_hsa045400.87759636
73Endocytosis_Homo sapiens_hsa041440.86596157
74Bladder cancer_Homo sapiens_hsa052190.85829517
75Glutathione metabolism_Homo sapiens_hsa004800.85250694
76Nitrogen metabolism_Homo sapiens_hsa009100.85216560
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83166183
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.82300643
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81745454
80Complement and coagulation cascades_Homo sapiens_hsa046100.80786393
81Salivary secretion_Homo sapiens_hsa049700.80682918
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78558578
83Ovarian steroidogenesis_Homo sapiens_hsa049130.78235107
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78054903
85Adherens junction_Homo sapiens_hsa045200.77573582
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76125042
87Proteoglycans in cancer_Homo sapiens_hsa052050.74616677
88Chronic myeloid leukemia_Homo sapiens_hsa052200.74408022
89VEGF signaling pathway_Homo sapiens_hsa043700.74023391
90Ras signaling pathway_Homo sapiens_hsa040140.72974155
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.72141224
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.71395271
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71236556
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68041782
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67973902
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67625328
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66774238
98Carbon metabolism_Homo sapiens_hsa012000.66616840
99Caffeine metabolism_Homo sapiens_hsa002320.65843447
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64394090
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63136346
102Glycerolipid metabolism_Homo sapiens_hsa005610.62642289
103cAMP signaling pathway_Homo sapiens_hsa040240.61620294
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61595961
105Starch and sucrose metabolism_Homo sapiens_hsa005000.60772780
106Renin-angiotensin system_Homo sapiens_hsa046140.60524047
107Oxytocin signaling pathway_Homo sapiens_hsa049210.60025483
108Cocaine addiction_Homo sapiens_hsa050300.59128342
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.58799226
110Platelet activation_Homo sapiens_hsa046110.58396072
111Glioma_Homo sapiens_hsa052140.58358163
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58305066
113Peroxisome_Homo sapiens_hsa041460.57025226
114Mineral absorption_Homo sapiens_hsa049780.56726434
115Insulin resistance_Homo sapiens_hsa049310.56070648
116Taste transduction_Homo sapiens_hsa047420.55998047
117Circadian entrainment_Homo sapiens_hsa047130.55742439
118GABAergic synapse_Homo sapiens_hsa047270.54815628
119Vibrio cholerae infection_Homo sapiens_hsa051100.52881519
120GnRH signaling pathway_Homo sapiens_hsa049120.52644768
121Insulin secretion_Homo sapiens_hsa049110.52480479
122Hippo signaling pathway_Homo sapiens_hsa043900.51685010
123Estrogen signaling pathway_Homo sapiens_hsa049150.51326055
124Viral myocarditis_Homo sapiens_hsa054160.50811515
125Steroid biosynthesis_Homo sapiens_hsa001000.50458678
126beta-Alanine metabolism_Homo sapiens_hsa004100.50060630
127Small cell lung cancer_Homo sapiens_hsa052220.50029091
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49246849
129Melanogenesis_Homo sapiens_hsa049160.48930975
130Fat digestion and absorption_Homo sapiens_hsa049750.48777091
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.48276983
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48227485
133Thyroid hormone synthesis_Homo sapiens_hsa049180.48001872
134Thyroid cancer_Homo sapiens_hsa052160.47763964
135Sulfur metabolism_Homo sapiens_hsa009200.47697602
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47396438
137Calcium signaling pathway_Homo sapiens_hsa040200.47215484
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46881286
139Notch signaling pathway_Homo sapiens_hsa043300.46847043
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46591131
141Endometrial cancer_Homo sapiens_hsa052130.46322547
142Morphine addiction_Homo sapiens_hsa050320.45599100
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.45299189
144Huntingtons disease_Homo sapiens_hsa050160.44998496
145Folate biosynthesis_Homo sapiens_hsa007900.43102442
146Synaptic vesicle cycle_Homo sapiens_hsa047210.40531042
147Pancreatic cancer_Homo sapiens_hsa052120.40493117
148mTOR signaling pathway_Homo sapiens_hsa041500.39993500

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