SLC9A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.74862355
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.61091720
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55800070
4locomotory exploration behavior (GO:0035641)5.36044140
5meiotic chromosome segregation (GO:0045132)5.21768563
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.18695656
7vocalization behavior (GO:0071625)4.95578105
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80278898
9regulation of synapse structural plasticity (GO:0051823)4.67122823
10synaptic vesicle exocytosis (GO:0016079)4.63917030
11layer formation in cerebral cortex (GO:0021819)4.63462551
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.61964934
13regulation of glutamate receptor signaling pathway (GO:1900449)4.32406949
14protein localization to synapse (GO:0035418)4.28559776
15neurotransmitter secretion (GO:0007269)4.21015856
16positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.18833739
17cellular response to ATP (GO:0071318)4.14022258
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.09959513
19glutamate secretion (GO:0014047)4.07058005
20regulation of synaptic vesicle exocytosis (GO:2000300)4.03927988
21GDP-mannose metabolic process (GO:0019673)4.03040576
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.00243487
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97608311
24DNA strand renaturation (GO:0000733)3.95133807
25semaphorin-plexin signaling pathway (GO:0071526)3.94442865
26positive regulation of synapse maturation (GO:0090129)3.93866582
27dendritic spine morphogenesis (GO:0060997)3.90153485
28proline biosynthetic process (GO:0006561)3.90127193
29mannose metabolic process (GO:0006013)3.89123402
30cerebellar Purkinje cell differentiation (GO:0021702)3.83793427
31exploration behavior (GO:0035640)3.79451250
32neuronal action potential propagation (GO:0019227)3.75134415
33neuromuscular process controlling balance (GO:0050885)3.74292595
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.72869254
35regulation of neuronal synaptic plasticity (GO:0048168)3.72793973
36adenine nucleotide transport (GO:0051503)3.68759566
37prepulse inhibition (GO:0060134)3.68733845
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.67788699
39gamma-aminobutyric acid transport (GO:0015812)3.67260940
40synaptic transmission, glutamatergic (GO:0035249)3.63289259
41neuron cell-cell adhesion (GO:0007158)3.59007099
42protein retention in ER lumen (GO:0006621)3.58870684
43glutamate receptor signaling pathway (GO:0007215)3.57339073
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55477327
45adenosine receptor signaling pathway (GO:0001973)3.55033063
46establishment of nucleus localization (GO:0040023)3.52006141
47positive regulation of membrane potential (GO:0045838)3.50599655
48regulation of translational fidelity (GO:0006450)3.48996997
49neuron-neuron synaptic transmission (GO:0007270)3.47797131
50regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.43555496
51sodium ion export (GO:0071436)3.41812837
52regulation of synaptic vesicle transport (GO:1902803)3.38937493
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37486188
54regulation of postsynaptic membrane potential (GO:0060078)3.37010735
55auditory behavior (GO:0031223)3.36716753
56long-term memory (GO:0007616)3.34944407
57neurotransmitter-gated ion channel clustering (GO:0072578)3.33614955
58cellular potassium ion homeostasis (GO:0030007)3.33524241
59regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.32956748
60regulation of dendritic spine morphogenesis (GO:0061001)3.32719585
61cell migration in hindbrain (GO:0021535)3.29914778
62positive regulation of neurotransmitter transport (GO:0051590)3.28878670
63activation of protein kinase A activity (GO:0034199)3.25677838
64adherens junction assembly (GO:0034333)3.24247204
65cell-substrate adherens junction assembly (GO:0007045)3.20744781
66focal adhesion assembly (GO:0048041)3.20744781
67proline metabolic process (GO:0006560)3.20343243
68membrane depolarization during action potential (GO:0086010)3.19809946
69dendrite morphogenesis (GO:0048813)3.19737339
70regulation of ARF GTPase activity (GO:0032312)3.19522934
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.14092939
72positive regulation of protein kinase C signaling (GO:0090037)3.12168547
73neurotransmitter transport (GO:0006836)3.11404589
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07979941
75behavioral response to cocaine (GO:0048148)3.06903138
76synaptonemal complex assembly (GO:0007130)3.05007335
77membrane hyperpolarization (GO:0060081)3.04950056
78peptidyl-glutamic acid carboxylation (GO:0017187)3.04245089
79protein carboxylation (GO:0018214)3.04245089
80transmission of nerve impulse (GO:0019226)3.02339784
81negative regulation of cell aging (GO:0090344)3.01693249
82DNA replication checkpoint (GO:0000076)3.01354324
83membrane depolarization (GO:0051899)3.01081330
84regulation of neurotransmitter levels (GO:0001505)2.96637623
85regulation of mammary gland epithelial cell proliferation (GO:0033599)2.95862580
86regulation of NFAT protein import into nucleus (GO:0051532)2.95825829
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.95634576
88axonal fasciculation (GO:0007413)2.95426241
89positive regulation of dendritic spine development (GO:0060999)2.95200961
90neuron recognition (GO:0008038)2.94957604
91behavioral fear response (GO:0001662)2.94357468
92behavioral defense response (GO:0002209)2.94357468
93regulation of synaptic plasticity (GO:0048167)2.94284316
94regulation of skeletal muscle contraction (GO:0014819)2.91797029
95neuromuscular process (GO:0050905)2.91029002
96dopamine receptor signaling pathway (GO:0007212)2.90701610
97DNA synthesis involved in DNA repair (GO:0000731)2.90398779
98regulation of voltage-gated calcium channel activity (GO:1901385)2.90299621
99response to histamine (GO:0034776)2.89586781
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89536250
101neuronal ion channel clustering (GO:0045161)2.88974961
102regulation of neurotransmitter secretion (GO:0046928)2.88519442
103response to auditory stimulus (GO:0010996)2.87943162
104postsynaptic membrane organization (GO:0001941)2.87489971
105vesicle transport along microtubule (GO:0047496)2.86836756
106cerebellar granule cell differentiation (GO:0021707)2.86477185
107regulation of dendritic spine development (GO:0060998)2.86456552
108social behavior (GO:0035176)2.85985188
109intraspecies interaction between organisms (GO:0051703)2.85985188
110cerebellar Purkinje cell layer development (GO:0021680)2.85895978
111mating behavior (GO:0007617)2.85377512
112proline transport (GO:0015824)2.84868203
113bone trabecula formation (GO:0060346)2.84693809
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.84085439
115negative regulation of cell size (GO:0045792)2.83891596
116sensory perception of taste (GO:0050909)2.83440883
117G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83234604
118synaptic vesicle endocytosis (GO:0048488)2.82882227
119regulation of synapse maturation (GO:0090128)2.81136880
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.79763405
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78857913
122heterochromatin organization (GO:0070828)2.78815234
123fear response (GO:0042596)2.78298710
124purine nucleotide transport (GO:0015865)2.78130326
125cell communication by electrical coupling (GO:0010644)2.77941777
126positive regulation of neurotransmitter secretion (GO:0001956)2.77906939
127regulation of clathrin-mediated endocytosis (GO:2000369)2.77843403
128negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.76981749
129synaptic transmission, dopaminergic (GO:0001963)2.76899623
130mechanosensory behavior (GO:0007638)2.76122650
131positive regulation of fibroblast migration (GO:0010763)2.74340933
132visual learning (GO:0008542)2.73966989
133neuromuscular process controlling posture (GO:0050884)2.73771367
134negative regulation of microtubule polymerization (GO:0031115)2.73313272
135DNA duplex unwinding (GO:0032508)2.70762040
136synaptonemal complex organization (GO:0070193)2.66663554
137histone H4 deacetylation (GO:0070933)2.65182213
138UV protection (GO:0009650)2.65001219
139purine ribonucleotide transport (GO:0015868)2.62816572
140DNA damage induced protein phosphorylation (GO:0006975)2.61728641
141histone H3-K9 demethylation (GO:0033169)2.56888980
142stress granule assembly (GO:0034063)2.56436666
143activation of Rac GTPase activity (GO:0032863)2.55849313
144endocytic recycling (GO:0032456)2.55760445
145convergent extension (GO:0060026)2.54487108
146nuclear pore complex assembly (GO:0051292)2.53660085
147mitotic chromosome condensation (GO:0007076)2.53608017
148protein insertion into membrane (GO:0051205)2.52386449
149lens fiber cell differentiation (GO:0070306)2.52221648
150histone deubiquitination (GO:0016578)2.51792444
151DNA geometric change (GO:0032392)2.50306886
152cochlea morphogenesis (GO:0090103)2.50285105
153regulation of histone H3-K27 methylation (GO:0061085)2.49748498
154regulation of nucleobase-containing compound transport (GO:0032239)2.48353965
155regulation of RNA export from nucleus (GO:0046831)2.46092758
156lung epithelium development (GO:0060428)2.45739456
157Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.45614079
158cell-cell junction maintenance (GO:0045217)2.45503609
159negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42887201
160endothelial cell chemotaxis (GO:0035767)2.42733158
161histone phosphorylation (GO:0016572)2.42073882
162atrioventricular valve morphogenesis (GO:0003181)2.42057768
163cell-substrate junction assembly (GO:0007044)2.42016394
164histone H3 deacetylation (GO:0070932)2.41723227
165retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.36391026
166mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.36132461
167negative regulation of catenin import into nucleus (GO:0035414)2.35751197
168rRNA methylation (GO:0031167)2.35588447
169protein hydroxylation (GO:0018126)2.35249223
170regulation of hydrogen peroxide metabolic process (GO:0010310)2.35165561
171histone H3-K36 demethylation (GO:0070544)2.34032817
172regulation of ARF protein signal transduction (GO:0032012)2.33950323
173misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.33800764
174phosphate ion transmembrane transport (GO:0035435)2.32121178
175basement membrane organization (GO:0071711)2.30877286
176snRNA metabolic process (GO:0016073)2.30220494
177positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29971206
178regulation of establishment of planar polarity (GO:0090175)2.26852344
179respiratory tube development (GO:0030323)2.26642076
180type B pancreatic cell proliferation (GO:0044342)2.26609816
181embryonic body morphogenesis (GO:0010172)2.26436460
182chromosome organization involved in meiosis (GO:0070192)2.25769692
183cranial nerve morphogenesis (GO:0021602)2.24754285
184gonadal mesoderm development (GO:0007506)2.21853513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.49960933
2* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.22502696
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.14118669
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.83066030
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78915025
6VDR_21846776_ChIP-Seq_THP-1_Human2.77865110
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76516711
8DROSHA_22980978_ChIP-Seq_HELA_Human2.74338698
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.71722529
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65720047
11E2F7_22180533_ChIP-Seq_HELA_Human2.61115829
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59259602
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59259602
14REST_21632747_ChIP-Seq_MESCs_Mouse2.57516341
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56458379
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.51196941
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45585775
18P68_20966046_ChIP-Seq_HELA_Human2.36047052
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33412548
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27906277
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.27491657
22* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.26473406
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24984928
24RACK7_27058665_Chip-Seq_MCF-7_Human2.22960023
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22769652
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22217086
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20281336
28GBX2_23144817_ChIP-Seq_PC3_Human2.19672575
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19194263
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17523959
31* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16995745
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.16333841
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.13257922
34REST_18959480_ChIP-ChIP_MESCs_Mouse2.12518208
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08323159
36ELK3_25401928_ChIP-Seq_HUVEC_Human2.05930746
37MYC_22102868_ChIP-Seq_BL_Human2.05230679
38ERG_21242973_ChIP-ChIP_JURKAT_Human2.03109816
39XRN2_22483619_ChIP-Seq_HELA_Human1.97289507
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.97058633
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91536969
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.89031560
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.86966194
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.79602475
45KDM2B_26808549_Chip-Seq_K562_Human1.75347607
46MAF_26560356_Chip-Seq_TH2_Human1.70380994
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70021692
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68058513
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67834495
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.67521800
51MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.67489654
52TCF7_22412390_ChIP-Seq_EML_Mouse1.66827321
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.66199264
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.65668717
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65484751
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61775511
57ZNF274_21170338_ChIP-Seq_K562_Hela1.60263395
58TP53_22127205_ChIP-Seq_IMR90_Human1.59423734
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57064870
60RARA_24833708_ChIP-Seq_LIVER_Mouse1.54746487
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54659527
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.51182487
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.50245788
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48232161
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.45880134
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44347434
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44026953
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43908460
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.43492278
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.42932401
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42917379
72RARB_24833708_ChIP-Seq_LIVER_Mouse1.42529799
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41803116
74ATF3_27146783_Chip-Seq_COLON_Human1.40685773
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40442983
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40414691
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40085384
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39529241
79PHF8_20622854_ChIP-Seq_HELA_Human1.38288461
80BCOR_27268052_Chip-Seq_Bcells_Human1.38064418
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36982412
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36535270
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.36160871
84BCL6_27268052_Chip-Seq_Bcells_Human1.35961629
85* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34170529
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33510077
87E2F1_20622854_ChIP-Seq_HELA_Human1.32966040
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31831729
89SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.29575655
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28980364
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28465781
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28283942
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28124389
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27414103
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26419455
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25893938
97AR_21572438_ChIP-Seq_LNCaP_Human1.23456007
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23259690
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.22880702
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22239614
101* AR_19668381_ChIP-Seq_PC3_Human1.21954600
102KDM2B_26808549_Chip-Seq_DND41_Human1.21839221
103CTCF_21964334_Chip-Seq_Bcells_Human1.21199151
104RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20588186
105NCOR1_26117541_ChIP-Seq_K562_Human1.20429748
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19942696
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19918569
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17085155
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16593321
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16205820
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.14895180
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14467378
113GATA1_26923725_Chip-Seq_HPCs_Mouse1.13960890
114MAF_26560356_Chip-Seq_TH1_Human1.13908001
115ZNF263_19887448_ChIP-Seq_K562_Human1.12419525
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11559591
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.10597887
118CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08518046
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.07395480
120THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07119615
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05899211
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05525275
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05343235
124ETS1_21867929_ChIP-Seq_TH2_Mouse1.04839193
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04487808
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04355457
127YY1_22570637_ChIP-Seq_MALME-3M_Human1.03252577
128SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02674215
129SMAD4_21799915_ChIP-Seq_A2780_Human1.02150090
130FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01585305
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01456058
132CTCF_27219007_Chip-Seq_Bcells_Human1.01394349
133ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00310773
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00177281
135* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99079667
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99070021
137SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99041710
138TP53_23651856_ChIP-Seq_MEFs_Mouse0.98705085
139RUNX1_27514584_Chip-Seq_MCF-7_Human0.98528272
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.98398311
141PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98058411
142* LXR_22292898_ChIP-Seq_THP-1_Human0.97862757
143ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97087788
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96769124
145TET1_21490601_ChIP-Seq_MESCs_Mouse0.95985713
146KLF4_19829295_ChIP-Seq_ESCs_Human0.95893878
147SMC4_20622854_ChIP-Seq_HELA_Human0.95126058
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94745125
149CREB1_26743006_Chip-Seq_LNCaP_Human0.94310276
150STAT3_23295773_ChIP-Seq_U87_Human0.93251644
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92816905
152* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91999880
153CBX2_27304074_Chip-Seq_ESCs_Mouse0.91385668
154TCF4_23295773_ChIP-Seq_U87_Human0.90517514
155KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90402061
156* OCT4_19829295_ChIP-Seq_ESCs_Human0.90200273
157SMAD3_21741376_ChIP-Seq_EPCs_Human0.89597449
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89280429
159ISL1_27105846_Chip-Seq_CPCs_Mouse0.88494105
160SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87962494
161TP53_16413492_ChIP-PET_HCT116_Human0.87698449
162TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86250421
163VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86203249
164TP53_20018659_ChIP-ChIP_R1E_Mouse0.85839514
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82430890
166AHR_22903824_ChIP-Seq_MCF-7_Human0.82296722
167ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81854547
168DPY_21335234_ChIP-Seq_ESCs_Mouse0.80414222
169P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79927192
170WDR5_24793694_ChIP-Seq_LNCAP_Human0.79317708
171RNF2_27304074_Chip-Seq_NSC_Mouse0.78730942
172ARNT_22903824_ChIP-Seq_MCF-7_Human0.78549632
173SOX9_26525672_Chip-Seq_HEART_Mouse0.78020829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.01986807
2MP0003635_abnormal_synaptic_transmissio3.86689614
3MP0002822_catalepsy3.54340130
4MP0003880_abnormal_central_pattern3.46489102
5MP0005171_absent_coat_pigmentation3.29443116
6MP0009046_muscle_twitch3.22306554
7MP0009745_abnormal_behavioral_response3.00174592
8MP0002063_abnormal_learning/memory/cond2.99488293
9MP0001986_abnormal_taste_sensitivity2.96042411
10MP0004270_analgesia2.94532233
11MP0005423_abnormal_somatic_nervous2.94447127
12MP0005409_darkened_coat_color2.90477064
13MP0002064_seizures2.71725621
14MP0005174_abnormal_tail_pigmentation2.51562589
15MP0000569_abnormal_digit_pigmentation2.44533627
16MP0002572_abnormal_emotion/affect_behav2.43475720
17MP0010030_abnormal_orbit_morphology2.43191188
18MP0001968_abnormal_touch/_nociception2.33865556
19MP0003787_abnormal_imprinting2.25629676
20MP0001661_extended_life_span2.21026785
21MP0001486_abnormal_startle_reflex2.15190665
22MP0003136_yellow_coat_color2.10667990
23MP0002272_abnormal_nervous_system2.07907391
24MP0008438_abnormal_cutaneous_collagen2.06534929
25MP0003111_abnormal_nucleus_morphology1.98719500
26MP0002734_abnormal_mechanical_nocicepti1.96538925
27MP0003283_abnormal_digestive_organ1.91096084
28MP0000003_abnormal_adipose_tissue1.88243881
29MP0008569_lethality_at_weaning1.86762666
30MP0009384_cardiac_valve_regurgitation1.84840280
31MP0004811_abnormal_neuron_physiology1.83884926
32MP0002184_abnormal_innervation1.75028964
33MP0003122_maternal_imprinting1.71010024
34MP0001440_abnormal_grooming_behavior1.69979452
35MP0005623_abnormal_meninges_morphology1.69571962
36MP0002067_abnormal_sensory_capabilities1.68830307
37MP0004858_abnormal_nervous_system1.65109346
38MP0002733_abnormal_thermal_nociception1.62962328
39MP0001501_abnormal_sleep_pattern1.62886169
40MP0005257_abnormal_intraocular_pressure1.62532256
41MP0002909_abnormal_adrenal_gland1.61706322
42MP0000778_abnormal_nervous_system1.61521059
43MP0001958_emphysema1.56576833
44MP0002557_abnormal_social/conspecific_i1.54912748
45MP0001346_abnormal_lacrimal_gland1.54878572
46MP0003879_abnormal_hair_cell1.53618883
47MP0002736_abnormal_nociception_after1.53430921
48MP0000955_abnormal_spinal_cord1.50019992
49MP0009780_abnormal_chondrocyte_physiolo1.48361182
50MP0004924_abnormal_behavior1.47435769
51MP0005386_behavior/neurological_phenoty1.47435769
52MP0008877_abnormal_DNA_methylation1.46440032
53MP0001970_abnormal_pain_threshold1.44787209
54MP0005083_abnormal_biliary_tract1.43384687
55MP0004272_abnormal_basement_membrane1.41297790
56MP0005410_abnormal_fertilization1.41191551
57MP0001849_ear_inflammation1.40829324
58MP0003453_abnormal_keratinocyte_physiol1.39954948
59MP0002882_abnormal_neuron_morphology1.37565014
60MP0000678_abnormal_parathyroid_gland1.34389725
61MP0002249_abnormal_larynx_morphology1.33542762
62MP0000751_myopathy1.32922012
63MP0000750_abnormal_muscle_regeneration1.32468895
64MP0002152_abnormal_brain_morphology1.32444192
65MP0005330_cardiomyopathy1.30334117
66MP0003279_aneurysm1.29395752
67MP0003329_amyloid_beta_deposits1.28367215
68MP0003121_genomic_imprinting1.28330242
69MP0002089_abnormal_postnatal_growth/wei1.28165227
70MP0002066_abnormal_motor_capabilities/c1.27985545
71MP0002735_abnormal_chemical_nociception1.27053497
72MP0003123_paternal_imprinting1.25695685
73MP0002653_abnormal_ependyma_morphology1.25149197
74MP0003566_abnormal_cell_adhesion1.22434895
75MP0008961_abnormal_basal_metabolism1.22005539
76MP0003077_abnormal_cell_cycle1.21285718
77MP0004233_abnormal_muscle_weight1.20098426
78MP0003091_abnormal_cell_migration1.15603240
79MP0010094_abnormal_chromosome_stability1.12639326
80MP0000747_muscle_weakness1.11027220
81MP0004885_abnormal_endolymph1.08275274
82MP0000759_abnormal_skeletal_muscle1.07863594
83MP0004957_abnormal_blastocyst_morpholog1.07150763
84MP0003693_abnormal_embryo_hatching1.07039932
85MP0003861_abnormal_nervous_system1.05522834
86MP0004087_abnormal_muscle_fiber1.05347049
87MP0000537_abnormal_urethra_morphology1.05019087
88MP0002254_reproductive_system_inflammat1.03439522
89MP0004145_abnormal_muscle_electrophysio1.02515438
90MP0002160_abnormal_reproductive_system1.01493233
91MP0000733_abnormal_muscle_development1.00517188
92MP0005076_abnormal_cell_differentiation0.97773700
93MP0005058_abnormal_lysosome_morphology0.95362832
94MP0005375_adipose_tissue_phenotype0.93962930
95MP0001299_abnormal_eye_distance/0.93603289
96MP0003633_abnormal_nervous_system0.92264288
97MP0000015_abnormal_ear_pigmentation0.92235717
98MP0005380_embryogenesis_phenotype0.91652092
99MP0001672_abnormal_embryogenesis/_devel0.91652092
100MP0004185_abnormal_adipocyte_glucose0.90207638
101MP0003115_abnormal_respiratory_system0.88915127
102MP0005501_abnormal_skin_physiology0.88515694
103MP0003698_abnormal_male_reproductive0.88287099
104MP0002080_prenatal_lethality0.87997852
105MP0003631_nervous_system_phenotype0.87944031
106MP0002210_abnormal_sex_determination0.87842931
107MP0001730_embryonic_growth_arrest0.87755545
108MP0005621_abnormal_cell_physiology0.87152296
109MP0003119_abnormal_digestive_system0.86935123
110MP0001984_abnormal_olfaction0.86325408
111MP0001177_atelectasis0.86163072
112MP0008260_abnormal_autophagy0.85761953
113MP0003984_embryonic_growth_retardation0.85506400
114MP0000534_abnormal_ureter_morphology0.84739368
115MP0003172_abnormal_lysosome_physiology0.84275677
116MP0003632_abnormal_nervous_system0.83252996
117MP0004197_abnormal_fetal_growth/weight/0.82969219
118MP0002877_abnormal_melanocyte_morpholog0.82580225
119MP0003705_abnormal_hypodermis_morpholog0.81736482
120MP0001529_abnormal_vocalization0.80138135
121MP0003385_abnormal_body_wall0.80024920
122MP0001697_abnormal_embryo_size0.79887209
123MP0002060_abnormal_skin_morphology0.79372485
124MP0004142_abnormal_muscle_tone0.79274369
125MP0008872_abnormal_physiological_respon0.78724355
126MP0002925_abnormal_cardiovascular_devel0.78569674
127MP0002069_abnormal_eating/drinking_beha0.78497211
128MP0002114_abnormal_axial_skeleton0.78490745
129MP0000350_abnormal_cell_proliferation0.78385668
130MP0002088_abnormal_embryonic_growth/wei0.77996097
131MP0000358_abnormal_cell_content/0.77496262
132MP0000538_abnormal_urinary_bladder0.77267373
133MP0005551_abnormal_eye_electrophysiolog0.77163461
134MP0002085_abnormal_embryonic_tissue0.76978275
135MP0002932_abnormal_joint_morphology0.76238218
136MP0005187_abnormal_penis_morphology0.76155270
137MP0000428_abnormal_craniofacial_morphol0.75563734
138MP0002084_abnormal_developmental_patter0.75262281
139MP0006276_abnormal_autonomic_nervous0.75228341
140MP0000013_abnormal_adipose_tissue0.75195206
141MP0005394_taste/olfaction_phenotype0.74768925
142MP0005499_abnormal_olfactory_system0.74768925
143MP0002234_abnormal_pharynx_morphology0.74558345
144MP0005503_abnormal_tendon_morphology0.73598602
145MP0005451_abnormal_body_composition0.73593003
146MP0008874_decreased_physiological_sensi0.73203211
147MP0004742_abnormal_vestibular_system0.73182229
148MP0006072_abnormal_retinal_apoptosis0.73072185
149MP0002086_abnormal_extraembryonic_tissu0.72328868
150MP0001943_abnormal_respiration0.72266127
151MP0001348_abnormal_lacrimal_gland0.72250591
152MP0010234_abnormal_vibrissa_follicle0.71948183
153MP0000767_abnormal_smooth_muscle0.71130057
154MP0009672_abnormal_birth_weight0.70989362
155MP0002081_perinatal_lethality0.70803745
156MP0010630_abnormal_cardiac_muscle0.70275583
157MP0002752_abnormal_somatic_nervous0.70213232
158MP0000631_abnormal_neuroendocrine_gland0.70082104
159MP0008007_abnormal_cellular_replicative0.69844445
160MP0010769_abnormal_survival0.68883143
161MP0003942_abnormal_urinary_system0.68604721
162MP0004085_abnormal_heartbeat0.68331526
163MP0001188_hyperpigmentation0.66910892
164MP0005646_abnormal_pituitary_gland0.66376191
165MP0002229_neurodegeneration0.66365418
166MP0008770_decreased_survivor_rate0.66024785
167MP0010768_mortality/aging0.65747190
168MP0010770_preweaning_lethality0.65364170
169MP0002082_postnatal_lethality0.65364170
170MP0003634_abnormal_glial_cell0.63910662
171MP0005167_abnormal_blood-brain_barrier0.61516504
172MP0001502_abnormal_circadian_rhythm0.58876447

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)4.91909590
2Myokymia (HP:0002411)4.80412807
3Focal motor seizures (HP:0011153)4.78466555
4Ulnar bowing (HP:0003031)4.50033785
5Focal seizures (HP:0007359)4.35701009
6Turricephaly (HP:0000262)4.24864524
7Thin bony cortex (HP:0002753)4.00681343
8Visual hallucinations (HP:0002367)3.75823031
9Progressive cerebellar ataxia (HP:0002073)3.63407877
10Action tremor (HP:0002345)3.53169150
11Rib fusion (HP:0000902)3.37939160
12Abnormality of the lower motor neuron (HP:0002366)3.27954224
13Akinesia (HP:0002304)3.23684037
14Poikiloderma (HP:0001029)3.19990712
15Epileptic encephalopathy (HP:0200134)3.18690175
16Protrusio acetabuli (HP:0003179)3.15997750
17Coronal craniosynostosis (HP:0004440)3.13102772
18Intestinal fistula (HP:0100819)3.09096892
19Gaze-evoked nystagmus (HP:0000640)3.06078389
20Pointed chin (HP:0000307)3.03322799
21Impaired vibration sensation in the lower limbs (HP:0002166)3.01983472
22Atonic seizures (HP:0010819)3.01272351
23Facial hemangioma (HP:0000329)3.00802847
24Rectal fistula (HP:0100590)2.97549408
25Rectovaginal fistula (HP:0000143)2.97549408
26Poor eye contact (HP:0000817)2.96369700
27Dysdiadochokinesis (HP:0002075)2.94994157
28Dysmetric saccades (HP:0000641)2.93918988
29Genetic anticipation (HP:0003743)2.93899858
30Broad-based gait (HP:0002136)2.90182333
31Abnormality of the intrinsic pathway (HP:0010989)2.88328491
32Vaginal fistula (HP:0004320)2.87606880
33Thin ribs (HP:0000883)2.86402217
34Annular pancreas (HP:0001734)2.81695009
35Impaired smooth pursuit (HP:0007772)2.81033617
36Premature rupture of membranes (HP:0001788)2.80949758
37Abnormality of ocular smooth pursuit (HP:0000617)2.77589165
38Impaired social interactions (HP:0000735)2.73734888
39Abnormal social behavior (HP:0012433)2.73734888
40Neoplasm of the heart (HP:0100544)2.70768468
41Squamous cell carcinoma (HP:0002860)2.68752304
42Depression (HP:0000716)2.67123381
43Hemiplegia (HP:0002301)2.67111262
44Urinary bladder sphincter dysfunction (HP:0002839)2.66989743
45Absence seizures (HP:0002121)2.62174806
46Febrile seizures (HP:0002373)2.62171100
47Genu recurvatum (HP:0002816)2.52659307
48Hyperacusis (HP:0010780)2.51599007
49Lower limb amyotrophy (HP:0007210)2.50607478
50Resting tremor (HP:0002322)2.50173167
51Bowing of the arm (HP:0006488)2.50131119
52Bowed forearm bones (HP:0003956)2.50131119
53Hemiparesis (HP:0001269)2.50110620
54Cervical subluxation (HP:0003308)2.48666773
55Insomnia (HP:0100785)2.40365334
56Urinary urgency (HP:0000012)2.39714644
57Hemorrhage of the eye (HP:0011885)2.38350790
58Atrioventricular block (HP:0001678)2.36611176
59Truncal ataxia (HP:0002078)2.36035075
60Dyschromatopsia (HP:0007641)2.35605069
61Biconcave vertebral bodies (HP:0004586)2.33376212
62Capillary hemangiomas (HP:0005306)2.33330564
63Ankle clonus (HP:0011448)2.32027051
64Generalized tonic-clonic seizures (HP:0002069)2.29387105
65Dysmetria (HP:0001310)2.24839466
66Scanning speech (HP:0002168)2.24161231
67Dialeptic seizures (HP:0011146)2.22755898
68Amyotrophic lateral sclerosis (HP:0007354)2.22325071
69Distal upper limb amyotrophy (HP:0007149)2.21930228
70Upper limb amyotrophy (HP:0009129)2.21930228
71Myopathic facies (HP:0002058)2.21696575
72Dislocated radial head (HP:0003083)2.19904374
73Supranuclear gaze palsy (HP:0000605)2.19690041
74Delayed epiphyseal ossification (HP:0002663)2.16247198
75Insidious onset (HP:0003587)2.13870956
76Termporal pattern (HP:0011008)2.13870956
77Mutism (HP:0002300)2.12895112
78Shallow orbits (HP:0000586)2.11477689
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.10518496
80Heterotopia (HP:0002282)2.10506728
81Abnormality of the astrocytes (HP:0100707)2.10341347
82Astrocytoma (HP:0009592)2.10341347
83Broad metatarsal (HP:0001783)2.09733078
84Papilledema (HP:0001085)2.09672610
85Anteriorly placed anus (HP:0001545)2.09612831
86Impaired vibratory sensation (HP:0002495)2.09399890
87Bladder diverticulum (HP:0000015)2.08337759
88Elfin facies (HP:0004428)2.07773425
89Fetal akinesia sequence (HP:0001989)2.07026471
90Joint stiffness (HP:0001387)2.05762660
91Patellar aplasia (HP:0006443)2.05315586
92Abnormality of the radial head (HP:0003995)2.04100571
93Dynein arm defect of respiratory motile cilia (HP:0012255)2.02595773
94Absent/shortened dynein arms (HP:0200106)2.02595773
95Macroorchidism (HP:0000053)2.02562646
96Renal duplication (HP:0000075)2.02461289
97Postural instability (HP:0002172)2.02430841
98Popliteal pterygium (HP:0009756)2.01718035
99Spastic gait (HP:0002064)2.01544485
100Male infertility (HP:0003251)2.01207403
101Megalencephaly (HP:0001355)2.00129141
102Pterygium (HP:0001059)1.99573926
103Stereotypic behavior (HP:0000733)1.98125944
104Trigonocephaly (HP:0000243)1.96960148
105Obsessive-compulsive behavior (HP:0000722)1.96894331
106Short chin (HP:0000331)1.96404821
107Distal lower limb amyotrophy (HP:0008944)1.93548635
108Inappropriate behavior (HP:0000719)1.93299615
109Ankyloglossia (HP:0010296)1.93269602
110Abnormal eating behavior (HP:0100738)1.91997655
111Cerebral aneurysm (HP:0004944)1.91733050
112Progressive external ophthalmoplegia (HP:0000590)1.91392291
113Neuronal loss in central nervous system (HP:0002529)1.91321666
114Aplasia of the musculature (HP:0100854)1.90987918
115Renovascular hypertension (HP:0100817)1.89596715
116Broad distal phalanx of finger (HP:0009836)1.89414166
117Disproportionate tall stature (HP:0001519)1.89016728
118Status epilepticus (HP:0002133)1.89007187
119Mitral regurgitation (HP:0001653)1.88339912
120Aplasia/Hypoplasia of the patella (HP:0006498)1.88278669
121Long palpebral fissure (HP:0000637)1.88189996
122Anxiety (HP:0000739)1.88031248
123Diplopia (HP:0000651)1.87957207
124Abnormality of binocular vision (HP:0011514)1.87957207
125Overriding aorta (HP:0002623)1.87116953
126Broad face (HP:0000283)1.86001347
127Bowel diverticulosis (HP:0005222)1.84881792
128Amblyopia (HP:0000646)1.84117868
129Increased number of teeth (HP:0011069)1.83988863
130Birth length less than 3rd percentile (HP:0003561)1.83610337
131Torticollis (HP:0000473)1.83580399
132Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83493526
133Short 4th metacarpal (HP:0010044)1.83493526
134Mildly elevated creatine phosphokinase (HP:0008180)1.82134489
135Narrow nasal bridge (HP:0000446)1.82058388
136Mask-like facies (HP:0000298)1.81703374
137Aqueductal stenosis (HP:0002410)1.81349839
138Hypoventilation (HP:0002791)1.80347891
139Excessive salivation (HP:0003781)1.80335007
140Drooling (HP:0002307)1.80335007
141Intention tremor (HP:0002080)1.79907004
142Facial diplegia (HP:0001349)1.79547547
143Abnormal atrioventricular conduction (HP:0005150)1.78173796
144Fragile skin (HP:0001030)1.76201831
145Choanal stenosis (HP:0000452)1.76159417
146Glioma (HP:0009733)1.75755554
147Myotonia (HP:0002486)1.75668138
148Horizontal nystagmus (HP:0000666)1.75630481
149Abnormality of oral frenula (HP:0000190)1.74098441
150Bradykinesia (HP:0002067)1.73825704
151Ependymoma (HP:0002888)1.73811850
152Absent radius (HP:0003974)1.73760808
153Spinal rigidity (HP:0003306)1.73702607
154Mesangial abnormality (HP:0001966)1.73533796
155Sacral dimple (HP:0000960)1.73047549
156Joint hemorrhage (HP:0005261)1.72525673
157Short humerus (HP:0005792)1.72440863
158Absent frontal sinuses (HP:0002688)1.71919273
159Postural tremor (HP:0002174)1.71765130
160Obstructive sleep apnea (HP:0002870)1.71311958
161Abnormality of dentin (HP:0010299)1.70482374
162Hand muscle atrophy (HP:0009130)1.70128624
163Rectal prolapse (HP:0002035)1.68572956
164Increased nuchal translucency (HP:0010880)1.68414676
165Atrophic scars (HP:0001075)1.67312241
166Zonular cataract (HP:0010920)1.66733258
167Arterial tortuosity (HP:0005116)1.66508117
168Absent speech (HP:0001344)1.66369288
169Slender long bone (HP:0003100)1.65812890
170Difficulty climbing stairs (HP:0003551)1.65719341
171Abnormality of the corticospinal tract (HP:0002492)1.64933751
172Lower limb muscle weakness (HP:0007340)1.64592187
173Prolonged partial thromboplastin time (HP:0003645)1.63344429
174Ventricular fibrillation (HP:0001663)1.62679068
175Generalized hypotonia (HP:0001290)1.62576475
176Increased connective tissue (HP:0009025)1.62501263
177Heart block (HP:0012722)1.62443777
178Basal cell carcinoma (HP:0002671)1.60482611
179Diminished movement (HP:0002374)1.59768773
180Spina bifida occulta (HP:0003298)1.59684086
181Mitral valve prolapse (HP:0001634)1.59171087
182Wormian bones (HP:0002645)1.58654677
183Aplasia involving forearm bones (HP:0009822)1.55694745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.59388163
2EPHA43.54957225
3NTRK33.51514939
4MAP3K42.98867634
5MET2.88689674
6MAPK152.74805326
7CAMKK12.61810879
8PRKD32.54471488
9CAMKK22.44320717
10DAPK22.41176922
11MARK12.33960296
12SIK12.30194189
13CAMK1G2.25160884
14TAOK22.24567423
15PAK62.23113333
16SMG12.20486839
17MST1R2.07935993
18MINK12.05202245
19PNCK2.04927993
20SIK22.01753173
21NTRK21.96111991
22ARAF1.82095972
23KSR21.81666474
24MAP2K71.76069827
25STK381.73568142
26TAOK11.71759039
27TYRO31.64547266
28CAMK1D1.60827417
29MAP2K41.57971911
30KSR11.55845552
31ALK1.55194008
32RIPK11.52774528
33ICK1.49397474
34ERBB41.43189357
35MAP2K61.42520452
36WNK41.41508306
37NTRK11.36202139
38LATS21.31431214
39RIPK41.30264399
40CDK51.30255086
41MAP2K31.25175122
42IRAK31.20212524
43DAPK11.19012233
44CDK151.18033875
45TTN1.17467419
46PTK2B1.14676787
47CDK181.13468187
48TRIB31.12786279
49ERN11.11211945
50UHMK11.08859076
51CDK11A1.05865152
52EPHA21.05265312
53WNK11.03388259
54PLK21.01973700
55CDK141.00507827
56RAF10.99724799
57STK110.99641508
58FGFR40.99369377
59EEF2K0.98359239
60PRKCG0.96184921
61PRPF4B0.93784737
62RET0.91916331
63MARK20.89118711
64PRKCH0.87183435
65CAMK10.85823499
66MAPK110.82002420
67BRSK10.81350272
68FES0.80445094
69CDK120.79388914
70PDGFRA0.79260384
71BRAF0.79009710
72BMX0.76121677
73PRKD20.74691606
74MAPK130.74204031
75CAMK40.73304411
76TTK0.72659655
77MAP3K80.72539115
78CDC42BPA0.72295382
79PDGFRB0.71803247
80NEK10.71465962
81CDC70.69433268
82PKN20.68848208
83BRD40.67626282
84PDK40.66691198
85PDK30.66691198
86PAK40.66610522
87ROCK10.66491396
88PIM20.66337920
89CDK70.66238931
90SCYL20.66075834
91DDR20.65943672
92MAP3K60.65283330
93MAPK120.65127263
94MOS0.64640553
95TLK10.63450304
96MELK0.63011654
97SGK10.62182858
98NEK20.61907296
99PAK20.61468320
100CDK190.57298952
101PTK20.57243699
102IRAK20.56788613
103AURKA0.56328671
104RPS6KA30.52549858
105SGK30.52268480
106MAP3K130.51938316
107LMTK20.50973855
108CSNK1G20.50689246
109CHEK20.50320961
110RPS6KA20.49610928
111CDK40.48651361
112GRK50.47773171
113MAPK100.47556293
114CDK10.47368122
115PRKCI0.46757891
116PAK30.46275885
117PAK10.45970243
118CAMK2A0.45782775
119MAP3K20.45081610
120TNIK0.44051359
121ERBB20.43674366
122CDK20.43572952
123TESK20.43491481
124TESK10.43433503
125CSNK1E0.43154368
126PTK60.42968825
127PDK10.42648679
128ATR0.42617814
129CHEK10.42389429
130FGFR10.42289349
131BLK0.42093107
132PRKDC0.41582877
133AKT20.41393549
134PHKG20.41262404
135PHKG10.41262404
136RPS6KL10.41074471
137RPS6KC10.41074471
138MAPK80.39595981
139PRKAA10.39358104
140DAPK30.38838264
141MTOR0.38313805
142PRKCZ0.38042227
143MAP3K70.37517191
144FYN0.37198641
145CDK60.36825044
146GSK3B0.36772501
147MAP3K100.36328158
148CSNK1D0.36210004
149PDPK10.34980035

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.04376013
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.85481352
3Sulfur relay system_Homo sapiens_hsa041222.83500951
4Synaptic vesicle cycle_Homo sapiens_hsa047212.71359914
5Long-term potentiation_Homo sapiens_hsa047202.50125827
6Olfactory transduction_Homo sapiens_hsa047402.49560734
7Circadian entrainment_Homo sapiens_hsa047132.38883697
8Glutamatergic synapse_Homo sapiens_hsa047242.28481717
9Amphetamine addiction_Homo sapiens_hsa050312.25091990
10GABAergic synapse_Homo sapiens_hsa047272.19451308
11Morphine addiction_Homo sapiens_hsa050322.19001057
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12834418
13Dopaminergic synapse_Homo sapiens_hsa047282.07083041
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03308296
15Fructose and mannose metabolism_Homo sapiens_hsa000511.98859417
16Salivary secretion_Homo sapiens_hsa049701.91278388
17Cholinergic synapse_Homo sapiens_hsa047251.81088451
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.78475643
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74554727
20Cocaine addiction_Homo sapiens_hsa050301.72763224
21Long-term depression_Homo sapiens_hsa047301.71362648
22Oxytocin signaling pathway_Homo sapiens_hsa049211.69548307
23Gastric acid secretion_Homo sapiens_hsa049711.68951883
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67686721
25Insulin secretion_Homo sapiens_hsa049111.60891150
26Renin secretion_Homo sapiens_hsa049241.58395959
27Gap junction_Homo sapiens_hsa045401.54453190
28GnRH signaling pathway_Homo sapiens_hsa049121.50049018
29Oocyte meiosis_Homo sapiens_hsa041141.48114002
30Taste transduction_Homo sapiens_hsa047421.43477686
31Other glycan degradation_Homo sapiens_hsa005111.43087612
32Glioma_Homo sapiens_hsa052141.42567560
33Lysine degradation_Homo sapiens_hsa003101.38432733
34Calcium signaling pathway_Homo sapiens_hsa040201.37081059
35Estrogen signaling pathway_Homo sapiens_hsa049151.34258180
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33954282
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32914845
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30192960
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29982369
40Type II diabetes mellitus_Homo sapiens_hsa049301.29759460
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21659789
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20960807
43Serotonergic synapse_Homo sapiens_hsa047261.19842547
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18623478
45cAMP signaling pathway_Homo sapiens_hsa040241.18213569
46Phototransduction_Homo sapiens_hsa047441.17698261
47Dorso-ventral axis formation_Homo sapiens_hsa043201.13968999
48Axon guidance_Homo sapiens_hsa043601.13928060
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13134918
50Melanogenesis_Homo sapiens_hsa049161.12381975
51ErbB signaling pathway_Homo sapiens_hsa040121.12380918
52Biosynthesis of amino acids_Homo sapiens_hsa012301.12140695
53Cell cycle_Homo sapiens_hsa041101.11156902
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04591869
55Notch signaling pathway_Homo sapiens_hsa043301.02799143
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.02431065
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02347608
58VEGF signaling pathway_Homo sapiens_hsa043701.02340639
59ECM-receptor interaction_Homo sapiens_hsa045121.01738777
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01176671
61mTOR signaling pathway_Homo sapiens_hsa041501.00919836
62N-Glycan biosynthesis_Homo sapiens_hsa005101.00103114
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99024933
64MicroRNAs in cancer_Homo sapiens_hsa052060.97995686
65Fanconi anemia pathway_Homo sapiens_hsa034600.97009534
66Base excision repair_Homo sapiens_hsa034100.96246397
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.94752964
68Dilated cardiomyopathy_Homo sapiens_hsa054140.94009091
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91474646
70MAPK signaling pathway_Homo sapiens_hsa040100.89511654
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.89336069
72DNA replication_Homo sapiens_hsa030300.84276475
73Small cell lung cancer_Homo sapiens_hsa052220.83838053
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.82928216
75Circadian rhythm_Homo sapiens_hsa047100.82780414
76Non-small cell lung cancer_Homo sapiens_hsa052230.82682328
77Hedgehog signaling pathway_Homo sapiens_hsa043400.78531160
78Alcoholism_Homo sapiens_hsa050340.78362611
79Rap1 signaling pathway_Homo sapiens_hsa040150.77748094
80Thyroid hormone synthesis_Homo sapiens_hsa049180.77634319
81Choline metabolism in cancer_Homo sapiens_hsa052310.76999472
82Cardiac muscle contraction_Homo sapiens_hsa042600.75694801
83Thyroid cancer_Homo sapiens_hsa052160.75070278
84Wnt signaling pathway_Homo sapiens_hsa043100.74781696
85Sphingolipid metabolism_Homo sapiens_hsa006000.73740745
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73190675
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72883084
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72339506
89Melanoma_Homo sapiens_hsa052180.71753653
90Adherens junction_Homo sapiens_hsa045200.71615691
91Glucagon signaling pathway_Homo sapiens_hsa049220.70928216
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70710959
93Endometrial cancer_Homo sapiens_hsa052130.70422146
94AMPK signaling pathway_Homo sapiens_hsa041520.69072180
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68569145
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67393159
97Pancreatic cancer_Homo sapiens_hsa052120.66007671
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.62702151
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62604925
100Pancreatic secretion_Homo sapiens_hsa049720.62207015
101Proteoglycans in cancer_Homo sapiens_hsa052050.62133420
102Hippo signaling pathway_Homo sapiens_hsa043900.61933726
103mRNA surveillance pathway_Homo sapiens_hsa030150.61258668
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60997770
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60413989
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59931967
107Acute myeloid leukemia_Homo sapiens_hsa052210.59096215
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58301118
109Colorectal cancer_Homo sapiens_hsa052100.57951114
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57348810
111Homologous recombination_Homo sapiens_hsa034400.57067233
112Basal cell carcinoma_Homo sapiens_hsa052170.56502083
113Insulin signaling pathway_Homo sapiens_hsa049100.56086268
114Inositol phosphate metabolism_Homo sapiens_hsa005620.56073821
115Chronic myeloid leukemia_Homo sapiens_hsa052200.56046360
116Endocytosis_Homo sapiens_hsa041440.56035867
117Ras signaling pathway_Homo sapiens_hsa040140.55582251
118Renal cell carcinoma_Homo sapiens_hsa052110.54876887
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53082754
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52834197
121Collecting duct acid secretion_Homo sapiens_hsa049660.52406805
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51958909
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51295636
124Prostate cancer_Homo sapiens_hsa052150.51226574
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50501699
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49609496
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.49571600
128Tight junction_Homo sapiens_hsa045300.47312276
129Focal adhesion_Homo sapiens_hsa045100.46331750
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45528174
131Bladder cancer_Homo sapiens_hsa052190.44968309
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43953004
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43743043
134Chemokine signaling pathway_Homo sapiens_hsa040620.43599610
135Nitrogen metabolism_Homo sapiens_hsa009100.43065128
136Platelet activation_Homo sapiens_hsa046110.41428403
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39858634

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