SLC9A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42500942
2synaptic vesicle maturation (GO:0016188)5.39368598
3locomotory exploration behavior (GO:0035641)5.33658714
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08469110
5synaptic vesicle exocytosis (GO:0016079)4.97786999
6vocalization behavior (GO:0071625)4.96274772
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.87040043
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.67300567
9glutamate secretion (GO:0014047)4.59422730
10regulation of synaptic vesicle exocytosis (GO:2000300)4.58513431
11neuron cell-cell adhesion (GO:0007158)4.53261261
12layer formation in cerebral cortex (GO:0021819)4.51199721
13protein localization to synapse (GO:0035418)4.47509748
14regulation of glutamate receptor signaling pathway (GO:1900449)4.44964140
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.44960671
16exploration behavior (GO:0035640)4.38316041
17L-amino acid import (GO:0043092)4.33912520
18neuronal action potential propagation (GO:0019227)4.31039575
19cerebellar granule cell differentiation (GO:0021707)4.27226603
20neurotransmitter secretion (GO:0007269)4.19782010
21regulation of synaptic vesicle transport (GO:1902803)4.06407271
22glutamate receptor signaling pathway (GO:0007215)4.01403359
23establishment of mitochondrion localization (GO:0051654)4.00890553
24amino acid import (GO:0043090)3.99559751
25regulation of synapse structural plasticity (GO:0051823)3.97989842
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97314863
27proline transport (GO:0015824)3.96077846
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.96015808
29cellular potassium ion homeostasis (GO:0030007)3.94164672
30regulation of neuronal synaptic plasticity (GO:0048168)3.89191771
31gamma-aminobutyric acid transport (GO:0015812)3.86727848
32dendritic spine morphogenesis (GO:0060997)3.86494712
33pyrimidine nucleobase catabolic process (GO:0006208)3.77015833
34presynaptic membrane assembly (GO:0097105)3.76332460
35neuron recognition (GO:0008038)3.75495912
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75086119
37synaptic transmission, glutamatergic (GO:0035249)3.65914980
38sodium ion export (GO:0071436)3.65478861
39neuron-neuron synaptic transmission (GO:0007270)3.61751607
40presynaptic membrane organization (GO:0097090)3.57415832
41long-term memory (GO:0007616)3.56865124
42neurotransmitter-gated ion channel clustering (GO:0072578)3.50675205
43neurotransmitter transport (GO:0006836)3.48671433
44negative regulation of dendrite morphogenesis (GO:0050774)3.48526449
45activation of protein kinase A activity (GO:0034199)3.48400239
46regulation of voltage-gated calcium channel activity (GO:1901385)3.48350349
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43720800
48cellular sodium ion homeostasis (GO:0006883)3.42876204
49axonal fasciculation (GO:0007413)3.42221177
50transmission of nerve impulse (GO:0019226)3.39754924
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38027825
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.36373934
53dendrite morphogenesis (GO:0048813)3.35933509
54potassium ion homeostasis (GO:0055075)3.32549582
55regulation of dendritic spine morphogenesis (GO:0061001)3.32290986
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.31092076
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30665703
58mitochondrion transport along microtubule (GO:0047497)3.28987244
59establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.28987244
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28759539
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.28069511
62mating behavior (GO:0007617)3.27937062
63neuromuscular process controlling balance (GO:0050885)3.26930859
64regulation of postsynaptic membrane potential (GO:0060078)3.24217338
65positive regulation of membrane potential (GO:0045838)3.23737865
66positive regulation of synapse maturation (GO:0090129)3.23183505
67regulation of neurotransmitter levels (GO:0001505)3.22296760
68regulation of ARF protein signal transduction (GO:0032012)3.21655757
69prepulse inhibition (GO:0060134)3.20412937
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20183133
71glycine transport (GO:0015816)3.17692023
72nucleobase catabolic process (GO:0046113)3.17238174
73neuromuscular process controlling posture (GO:0050884)3.16943393
74regulation of synapse maturation (GO:0090128)3.16862397
75acidic amino acid transport (GO:0015800)3.16595824
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15002486
77vesicle transport along microtubule (GO:0047496)3.14895230
78cerebellar Purkinje cell differentiation (GO:0021702)3.14114217
79regulation of synaptic plasticity (GO:0048167)3.13464240
80cell communication by electrical coupling (GO:0010644)3.12251123
81regulation of vesicle fusion (GO:0031338)3.11435154
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.11267733
83startle response (GO:0001964)3.10524958
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10110677
85cell communication involved in cardiac conduction (GO:0086065)3.09138180
86long-term synaptic potentiation (GO:0060291)3.08195750
87synaptic vesicle endocytosis (GO:0048488)3.03844790
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03570481
89membrane depolarization during action potential (GO:0086010)3.03294238
90positive regulation of synapse assembly (GO:0051965)3.01967643
91synapse assembly (GO:0007416)3.00775471
92synaptic vesicle transport (GO:0048489)3.00543679
93establishment of synaptic vesicle localization (GO:0097480)3.00543679
94cell migration in hindbrain (GO:0021535)2.99865934
95regulation of neurotransmitter secretion (GO:0046928)2.99687051
96neurotransmitter uptake (GO:0001504)2.98436770
97membrane depolarization (GO:0051899)2.94989700
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94392137
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93817166
100organelle transport along microtubule (GO:0072384)2.92692701
101central nervous system projection neuron axonogenesis (GO:0021952)2.91278240
102positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90943645
103neuromuscular synaptic transmission (GO:0007274)2.89993692
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88786072
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87071056
106learning (GO:0007612)2.85309567
107social behavior (GO:0035176)2.85108656
108intraspecies interaction between organisms (GO:0051703)2.85108656
109regulation of dendritic spine development (GO:0060998)2.83885177
110membrane hyperpolarization (GO:0060081)2.83502788
111innervation (GO:0060384)2.82908982
112postsynaptic membrane organization (GO:0001941)2.81591609
113response to auditory stimulus (GO:0010996)2.80988988
114positive regulation of dendritic spine development (GO:0060999)2.80740330
115response to histamine (GO:0034776)2.80257794
116positive regulation of potassium ion transmembrane transport (GO:1901381)2.79949707
117regulation of neurotransmitter transport (GO:0051588)2.79734450
118* synapse organization (GO:0050808)2.79631641
119neuronal ion channel clustering (GO:0045161)2.79502168
120behavioral fear response (GO:0001662)2.79484254
121behavioral defense response (GO:0002209)2.79484254
122potassium ion import (GO:0010107)2.79452409
123regulation of clathrin-mediated endocytosis (GO:2000369)2.77781225
124neuromuscular process (GO:0050905)2.76432262
125synaptic transmission (GO:0007268)2.75905025
126auditory behavior (GO:0031223)2.75349259
127adult walking behavior (GO:0007628)2.73729431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59140317
2GBX2_23144817_ChIP-Seq_PC3_Human3.10468850
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08581437
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06992800
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01657062
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73322075
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73322075
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59996141
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58066880
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54106663
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51149509
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51143715
13REST_21632747_ChIP-Seq_MESCs_Mouse2.50128061
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48441549
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.44234730
16DROSHA_22980978_ChIP-Seq_HELA_Human2.32385883
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.32026947
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.26151645
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.18379367
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17744267
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.10568855
22AR_21572438_ChIP-Seq_LNCaP_Human2.08195085
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.02796605
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90928671
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87363185
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82686145
27TAF15_26573619_Chip-Seq_HEK293_Human1.78569912
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75200303
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74258129
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73742673
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64514451
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64123140
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63679744
34SMAD4_21799915_ChIP-Seq_A2780_Human1.60973668
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.58956336
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58737377
37ZNF274_21170338_ChIP-Seq_K562_Hela1.49610377
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45076886
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44518247
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43133850
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42930242
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42440332
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36926200
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36058818
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.32981936
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32329496
47P300_19829295_ChIP-Seq_ESCs_Human1.31408328
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.29219009
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28038074
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27496007
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.27274138
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27193325
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.25226669
54AR_25329375_ChIP-Seq_VCAP_Human1.23894899
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23399616
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.23272366
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23186714
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.19615833
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.19501694
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17766137
61STAT3_23295773_ChIP-Seq_U87_Human1.17584049
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17430710
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17361480
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17058922
65AR_19668381_ChIP-Seq_PC3_Human1.16378040
66IGF1R_20145208_ChIP-Seq_DFB_Human1.16369853
67LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16092247
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13365855
69AHR_22903824_ChIP-Seq_MCF-7_Human1.12545619
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.12416071
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12252052
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11276813
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10149108
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.10042363
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07683573
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07592917
77TET1_21490601_ChIP-Seq_MESCs_Mouse1.06990837
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.06092063
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05898237
80KDM2B_26808549_Chip-Seq_K562_Human1.05767629
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05611281
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02995784
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01981114
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01523168
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01322073
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01200907
87TCF4_23295773_ChIP-Seq_U87_Human1.00314751
88YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99256246
89KDM2B_26808549_Chip-Seq_REH_Human0.98388421
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98216771
91SOX9_26525672_Chip-Seq_HEART_Mouse0.97279496
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97199234
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96531373
94JUN_21703547_ChIP-Seq_K562_Human0.96296517
95RNF2_27304074_Chip-Seq_NSC_Mouse0.96292070
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96193277
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95867247
98* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95768459
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.95543984
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95386897
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.94999833
102TP53_16413492_ChIP-PET_HCT116_Human0.94981585
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94891962
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94891962
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94783257
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.94666585
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93864499
108* RUNX2_22187159_ChIP-Seq_PCA_Human0.93749633
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92049353
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90768989
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90153007
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90084627
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89969206
114FLI1_21867929_ChIP-Seq_TH2_Mouse0.88979940
115TP53_18474530_ChIP-ChIP_U2OS_Human0.88142654
116BCAT_22108803_ChIP-Seq_LS180_Human0.87295288
117ER_23166858_ChIP-Seq_MCF-7_Human0.87157014
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86595289
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86118016
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85703680
121RXR_22108803_ChIP-Seq_LS180_Human0.85604331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.01460375
2MP0003880_abnormal_central_pattern4.64207279
3MP0003635_abnormal_synaptic_transmissio4.02768662
4MP0004270_analgesia3.75617841
5* MP0009745_abnormal_behavioral_response3.22936704
6MP0002063_abnormal_learning/memory/cond3.20303554
7MP0001968_abnormal_touch/_nociception3.09520597
8* MP0002064_seizures3.06372013
9MP0009046_muscle_twitch3.03266810
10MP0005423_abnormal_somatic_nervous2.85343272
11MP0002734_abnormal_mechanical_nocicepti2.71041783
12MP0002572_abnormal_emotion/affect_behav2.67081737
13MP0002272_abnormal_nervous_system2.56961544
14MP0002735_abnormal_chemical_nociception2.50726278
15MP0001486_abnormal_startle_reflex2.43597061
16MP0001501_abnormal_sleep_pattern2.32221694
17MP0002736_abnormal_nociception_after2.31816218
18MP0002733_abnormal_thermal_nociception2.24519209
19MP0002822_catalepsy2.20623509
20MP0003329_amyloid_beta_deposits2.18911732
21MP0001440_abnormal_grooming_behavior2.16729547
22MP0001970_abnormal_pain_threshold2.08231392
23MP0006276_abnormal_autonomic_nervous2.02859217
24MP0002067_abnormal_sensory_capabilities1.99331632
25MP0004858_abnormal_nervous_system1.94589970
26MP0009780_abnormal_chondrocyte_physiolo1.92723215
27MP0000778_abnormal_nervous_system1.91318133
28MP0002184_abnormal_innervation1.89974804
29MP0002909_abnormal_adrenal_gland1.82887436
30MP0008569_lethality_at_weaning1.80546977
31MP0005386_behavior/neurological_phenoty1.75913992
32MP0004924_abnormal_behavior1.75913992
33MP0004811_abnormal_neuron_physiology1.74491642
34MP0002557_abnormal_social/conspecific_i1.68664179
35MP0000955_abnormal_spinal_cord1.58508394
36MP0004885_abnormal_endolymph1.50358369
37* MP0002066_abnormal_motor_capabilities/c1.42680138
38MP0002882_abnormal_neuron_morphology1.41483008
39MP0003633_abnormal_nervous_system1.38334824
40MP0001529_abnormal_vocalization1.31890430
41MP0004145_abnormal_muscle_electrophysio1.29963842
42MP0000751_myopathy1.29256794
43MP0005645_abnormal_hypothalamus_physiol1.28808591
44MP0003122_maternal_imprinting1.27640694
45MP0004142_abnormal_muscle_tone1.26451711
46MP0001984_abnormal_olfaction1.25120878
47MP0005646_abnormal_pituitary_gland1.25045537
48MP0003879_abnormal_hair_cell1.23337460
49MP0008877_abnormal_DNA_methylation1.18042520
50MP0003631_nervous_system_phenotype1.17974521
51MP0001905_abnormal_dopamine_level1.17558095
52MP0000920_abnormal_myelination1.15895069
53MP0000013_abnormal_adipose_tissue1.14554357
54MP0001502_abnormal_circadian_rhythm1.12451254
55MP0000604_amyloidosis1.12355989
56MP0003690_abnormal_glial_cell1.11232279
57MP0002152_abnormal_brain_morphology1.05597061
58MP0003634_abnormal_glial_cell1.05444545
59MP0003787_abnormal_imprinting1.05098466
60MP0002837_dystrophic_cardiac_calcinosis1.04647066
61MP0004147_increased_porphyrin_level1.03643068
62MP0004742_abnormal_vestibular_system1.03102034
63MP0002229_neurodegeneration1.03047260
64MP0000569_abnormal_digit_pigmentation1.01543178
65MP0005535_abnormal_body_temperature0.96693911
66MP0004130_abnormal_muscle_cell0.94767133
67MP0001177_atelectasis0.94216547
68MP0002069_abnormal_eating/drinking_beha0.93017534
69MP0002638_abnormal_pupillary_reflex0.88973410
70MP0003632_abnormal_nervous_system0.88508909
71MP0005551_abnormal_eye_electrophysiolog0.88439398
72MP0004085_abnormal_heartbeat0.86787792
73MP0010234_abnormal_vibrissa_follicle0.85230331
74MP0008874_decreased_physiological_sensi0.85086240
75MP0002090_abnormal_vision0.84222686
76MP0008961_abnormal_basal_metabolism0.83753857
77MP0004215_abnormal_myocardial_fiber0.83522677
78MP0010386_abnormal_urinary_bladder0.82849594
79MP0001188_hyperpigmentation0.82025156
80MP0005409_darkened_coat_color0.81299623
81MP0008872_abnormal_physiological_respon0.80161741
82MP0004233_abnormal_muscle_weight0.78366305
83MP0005623_abnormal_meninges_morphology0.78263227
84MP0002102_abnormal_ear_morphology0.77330482
85MP0004484_altered_response_of0.75683190
86MP0003075_altered_response_to0.75658856
87MP0001299_abnormal_eye_distance/0.75091019
88MP0003283_abnormal_digestive_organ0.75046898
89MP0003121_genomic_imprinting0.74823947
90MP0002752_abnormal_somatic_nervous0.74350789
91MP0001963_abnormal_hearing_physiology0.71967775
92MP0003861_abnormal_nervous_system0.71762476
93MP0003123_paternal_imprinting0.70231266
94MP0005167_abnormal_blood-brain_barrier0.68294245
95MP0003137_abnormal_impulse_conducting0.68228082
96MP0000747_muscle_weakness0.65100012
97MP0005394_taste/olfaction_phenotype0.61581809
98MP0005499_abnormal_olfactory_system0.61581809
99MP0004043_abnormal_pH_regulation0.59473923
100MP0010769_abnormal_survival0.59216122
101MP0000631_abnormal_neuroendocrine_gland0.58477913
102MP0001664_abnormal_digestion0.57945143
103MP0005187_abnormal_penis_morphology0.57219883
104MP0002082_postnatal_lethality0.56689324
105MP0010770_preweaning_lethality0.56689324
106MP0001943_abnormal_respiration0.56635093
107MP0001485_abnormal_pinna_reflex0.56182358
108MP0003938_abnormal_ear_development0.56117939
109MP0000026_abnormal_inner_ear0.56116760
110MP0002876_abnormal_thyroid_physiology0.55718126
111MP0010768_mortality/aging0.55471995
112MP0003172_abnormal_lysosome_physiology0.54606928
113MP0000579_abnormal_nail_morphology0.51759153
114MP0005620_abnormal_muscle_contractility0.51732969
115MP0004036_abnormal_muscle_relaxation0.51658367
116MP0004510_myositis0.50594440
117MP0002081_perinatal_lethality0.49445999
118MP0003956_abnormal_body_size0.49415347
119MP0001346_abnormal_lacrimal_gland0.48971482

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.66163562
2Myokymia (HP:0002411)6.19340414
3Focal seizures (HP:0007359)5.45845810
4Visual hallucinations (HP:0002367)5.09595007
5Atonic seizures (HP:0010819)4.44111317
6Action tremor (HP:0002345)4.43208260
7Supranuclear gaze palsy (HP:0000605)4.23022050
8Absence seizures (HP:0002121)4.08879806
9Progressive cerebellar ataxia (HP:0002073)4.06779284
10Epileptic encephalopathy (HP:0200134)3.98492166
11Febrile seizures (HP:0002373)3.83602567
12Dialeptic seizures (HP:0011146)3.75906488
13Ankle clonus (HP:0011448)3.58330431
14Neurofibrillary tangles (HP:0002185)3.54447347
15* Generalized tonic-clonic seizures (HP:0002069)3.47302749
16Cerebral inclusion bodies (HP:0100314)3.40749704
17Broad-based gait (HP:0002136)3.31190392
18Termporal pattern (HP:0011008)3.25032281
19Insidious onset (HP:0003587)3.25032281
20Poor eye contact (HP:0000817)3.19368513
21Depression (HP:0000716)3.14483635
22Abnormal eating behavior (HP:0100738)3.06549223
23Papilledema (HP:0001085)3.05875531
24Dysdiadochokinesis (HP:0002075)3.05139325
25Impaired social interactions (HP:0000735)3.02789257
26Abnormal social behavior (HP:0012433)3.02789257
27Dysmetria (HP:0001310)3.00917241
28Urinary urgency (HP:0000012)2.97651472
29Urinary bladder sphincter dysfunction (HP:0002839)2.97367490
30Anxiety (HP:0000739)2.94175001
31Impaired vibration sensation in the lower limbs (HP:0002166)2.93932651
32Postural instability (HP:0002172)2.90799031
33Abnormality of the corticospinal tract (HP:0002492)2.89401278
34Amblyopia (HP:0000646)2.82958222
35Hyperventilation (HP:0002883)2.81754217
36Diminished motivation (HP:0000745)2.77570178
37Intention tremor (HP:0002080)2.77293227
38Gaze-evoked nystagmus (HP:0000640)2.73157316
39* Truncal ataxia (HP:0002078)2.68720450
40Pheochromocytoma (HP:0002666)2.68021176
41Spastic gait (HP:0002064)2.63957178
42Scanning speech (HP:0002168)2.58362213
43Torticollis (HP:0000473)2.58044362
44Limb dystonia (HP:0002451)2.56571349
45Tetraplegia (HP:0002445)2.55725784
46Hemiparesis (HP:0001269)2.55415953
47Diplopia (HP:0000651)2.51060353
48Abnormality of binocular vision (HP:0011514)2.51060353
49Polyphagia (HP:0002591)2.47205306
50* Drooling (HP:0002307)2.39988909
51* Excessive salivation (HP:0003781)2.39988909
52Genetic anticipation (HP:0003743)2.39300594
53* Mutism (HP:0002300)2.38292348
54Megalencephaly (HP:0001355)2.37600121
55Bradykinesia (HP:0002067)2.35946988
56Split foot (HP:0001839)2.35424604
57Lower limb muscle weakness (HP:0007340)2.32329304
58Paraplegia (HP:0010550)2.31116413
59Focal dystonia (HP:0004373)2.30086190
60Spastic paraplegia (HP:0001258)2.29311334
61Neuroendocrine neoplasm (HP:0100634)2.27703281
62Spastic tetraparesis (HP:0001285)2.26191389
63Agitation (HP:0000713)2.23227190
64Delusions (HP:0000746)2.21056128
65Abnormality of the lower motor neuron (HP:0002366)2.20878064
66Cortical dysplasia (HP:0002539)2.20048616
67Ventricular fibrillation (HP:0001663)2.19801117
68Hemiplegia (HP:0002301)2.17659363
69Rapidly progressive (HP:0003678)2.16531170
70Impaired smooth pursuit (HP:0007772)2.16459448
71Epileptiform EEG discharges (HP:0011182)2.14049406
72Postural tremor (HP:0002174)2.13460804
73Craniofacial dystonia (HP:0012179)2.13175587
74Amyotrophic lateral sclerosis (HP:0007354)2.12882798
75Absent speech (HP:0001344)2.11524831
76Stereotypic behavior (HP:0000733)2.11444416
77Status epilepticus (HP:0002133)2.10406021
78Peripheral hypomyelination (HP:0007182)2.10374693
79EEG with generalized epileptiform discharges (HP:0011198)2.09000462
80Spastic tetraplegia (HP:0002510)2.06266641
81Fetal akinesia sequence (HP:0001989)2.04890061
82Generalized myoclonic seizures (HP:0002123)2.04752240
83* Progressive inability to walk (HP:0002505)2.04310791
84Hypoplasia of the corpus callosum (HP:0002079)2.04190204
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03640821
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02644046
87Degeneration of the lateral corticospinal tracts (HP:0002314)2.02644046
88Agnosia (HP:0010524)2.01891732
89Inappropriate behavior (HP:0000719)1.99723099
90Akinesia (HP:0002304)1.99162371
91Hypsarrhythmia (HP:0002521)1.98231756
92Dysmetric saccades (HP:0000641)1.96487051
93Gait ataxia (HP:0002066)1.96167386
94Clonus (HP:0002169)1.95940403
95Psychosis (HP:0000709)1.94604265
96Abnormality of ocular smooth pursuit (HP:0000617)1.94321756
97Lower limb asymmetry (HP:0100559)1.93026178
98Sleep apnea (HP:0010535)1.92995707
99Aqueductal stenosis (HP:0002410)1.91710915
100Rigidity (HP:0002063)1.90930547
101Annular pancreas (HP:0001734)1.89605653
102Hammertoe (HP:0001765)1.89580832
103Apathy (HP:0000741)1.89054136
104Neoplasm of the peripheral nervous system (HP:0100007)1.87980614
105* Neuronal loss in central nervous system (HP:0002529)1.87907343
106Resting tremor (HP:0002322)1.87810158
107Obstructive sleep apnea (HP:0002870)1.87528948
108Cerebral hypomyelination (HP:0006808)1.87131022
109Failure to thrive in infancy (HP:0001531)1.86953206
110Impaired vibratory sensation (HP:0002495)1.84394595
111* Abnormality of salivation (HP:0100755)1.84055927
112Hypoventilation (HP:0002791)1.83306093
113Hyperthyroidism (HP:0000836)1.80377295
114Morphological abnormality of the pyramidal tract (HP:0002062)1.79379154
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78407382
116Abnormality of saccadic eye movements (HP:0000570)1.77181406
117Lower limb amyotrophy (HP:0007210)1.76594199
118Blue irides (HP:0000635)1.76493038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.09753122
2MAP3K93.90520901
3MARK13.69394369
4EPHA43.53934760
5MAP3K42.90832973
6MINK12.75191262
7KSR22.44073330
8PAK62.26966828
9MAP2K72.19936241
10DAPK22.13311466
11NTRK12.08820142
12NTRK22.07795246
13MAP2K42.06100858
14RIPK41.94161916
15MAP3K121.86737392
16PRKD31.72037766
17KSR11.63571610
18CAMKK11.56601664
19CDK51.55313015
20PNCK1.55156967
21PHKG21.45653386
22PHKG11.45653386
23GRK51.44900656
24ARAF1.39774193
25MAP3K21.35002032
26MAPK131.33038869
27PLK21.30363334
28LATS21.22165347
29CASK1.20969986
30RET1.17274893
31TYRO31.15999143
32FES1.14887321
33SIK21.13774250
34UHMK11.12020301
35STK381.11338732
36CAMKK21.07990290
37PRKCG1.07572176
38DAPK11.05850240
39MAP3K131.04975907
40PAK31.03952345
41CSNK1A1L1.02457468
42TNIK1.02150348
43CSNK1G30.99224844
44NEK60.96525577
45CAMK2A0.96008273
46CDK190.94963372
47CDK140.93824417
48OXSR10.93377308
49PRPF4B0.92358712
50STK110.89915645
51LMTK20.87969664
52PRKCH0.87376367
53CDK150.87322951
54CDK180.87131745
55SGK2230.85968839
56SGK4940.85968839
57CAMK1G0.84943145
58CSNK1G20.82312442
59CAMK2B0.80544750
60FGFR20.80093284
61TRIM280.78899721
62RAF10.77861604
63WNK10.77359035
64CDK11A0.74010559
65CAMK40.71641660
66CAMK10.71405693
67STK390.71208780
68PINK10.70961240
69PTK2B0.70203558
70FER0.69378841
71PDPK10.68348036
72MAPK120.68176302
73MARK20.66890495
74DYRK1A0.65702560
75CSNK1G10.65481407
76SCYL20.64595380
77SGK10.64319881
78ALK0.63757993
79PDK10.63746819
80MAP3K10.62304560
81TAOK10.60741593
82FGR0.60619687
83DYRK20.60204300
84EPHA30.59727487
85MAP2K10.59492953
86BMPR20.58256696
87CAMK2D0.56543281
88WNK30.56421552
89FYN0.55645712
90ERBB30.55382276
91PRKCZ0.54174657
92PRKCE0.52592718
93LIMK10.50758418
94RIPK10.50003005
95BCR0.49690255
96CAMK2G0.48689213
97NME10.48494135
98MAP3K60.47812034
99SGK20.46914157
100SGK30.46907548
101ROCK20.46520991
102RPS6KA30.46176137
103CCNB10.46163772
104DMPK0.45383330
105RPS6KB10.44619825
106PKN10.44172681
107MAPK100.43616794
108WNK40.43595367
109TNK20.43540265
110CSNK1D0.41887811
111BRAF0.38997422
112RPS6KA20.36575734
113CDC42BPA0.35440995
114MOS0.34003745
115MAP4K20.33452487
116PRKAA10.31533518
117BRSK10.30921568
118PRKG10.28580210
119SIK30.26879055

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46238367
2Synaptic vesicle cycle_Homo sapiens_hsa047213.02446114
3GABAergic synapse_Homo sapiens_hsa047272.61332650
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47943715
5Long-term potentiation_Homo sapiens_hsa047202.46764143
6Circadian entrainment_Homo sapiens_hsa047132.40651238
7Glutamatergic synapse_Homo sapiens_hsa047242.37965468
8Olfactory transduction_Homo sapiens_hsa047402.30596774
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27619894
10Morphine addiction_Homo sapiens_hsa050322.27131017
11Amphetamine addiction_Homo sapiens_hsa050312.15869478
12Dopaminergic synapse_Homo sapiens_hsa047282.05566321
13Salivary secretion_Homo sapiens_hsa049702.04867551
14Gastric acid secretion_Homo sapiens_hsa049711.81586542
15Insulin secretion_Homo sapiens_hsa049111.77262781
16Cholinergic synapse_Homo sapiens_hsa047251.76349982
17Long-term depression_Homo sapiens_hsa047301.73104139
18Renin secretion_Homo sapiens_hsa049241.71508937
19Taste transduction_Homo sapiens_hsa047421.67402923
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66458340
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60028462
22Oxytocin signaling pathway_Homo sapiens_hsa049211.58579538
23Serotonergic synapse_Homo sapiens_hsa047261.56775335
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55469986
25Cocaine addiction_Homo sapiens_hsa050301.51684875
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46405008
27Collecting duct acid secretion_Homo sapiens_hsa049661.45185162
28Calcium signaling pathway_Homo sapiens_hsa040201.41763560
29GnRH signaling pathway_Homo sapiens_hsa049121.35142754
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34803079
31Gap junction_Homo sapiens_hsa045401.32569360
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25262100
33Axon guidance_Homo sapiens_hsa043601.20827058
34cAMP signaling pathway_Homo sapiens_hsa040241.18841276
35Type II diabetes mellitus_Homo sapiens_hsa049301.17387548
36Estrogen signaling pathway_Homo sapiens_hsa049151.12834633
37Glioma_Homo sapiens_hsa052141.08365638
38Nitrogen metabolism_Homo sapiens_hsa009101.05684955
39Vitamin B6 metabolism_Homo sapiens_hsa007501.05460869
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03520683
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03384272
42* Cardiac muscle contraction_Homo sapiens_hsa042601.01018026
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99936413
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97390060
45ErbB signaling pathway_Homo sapiens_hsa040120.96897800
46Melanogenesis_Homo sapiens_hsa049160.96272912
47Vibrio cholerae infection_Homo sapiens_hsa051100.93463701
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90654612
49Dorso-ventral axis formation_Homo sapiens_hsa043200.90421967
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.88415855
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.86884418
52Pancreatic secretion_Homo sapiens_hsa049720.80789824
53Dilated cardiomyopathy_Homo sapiens_hsa054140.77635830
54Thyroid hormone synthesis_Homo sapiens_hsa049180.77608702
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74188139
56Choline metabolism in cancer_Homo sapiens_hsa052310.73311571
57Oocyte meiosis_Homo sapiens_hsa041140.72554977
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72213662
59VEGF signaling pathway_Homo sapiens_hsa043700.71134431
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69299569
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68724575
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66755962
63MAPK signaling pathway_Homo sapiens_hsa040100.66388206
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.64534587
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.63971489
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63339120
67Phototransduction_Homo sapiens_hsa047440.60793594
68Renal cell carcinoma_Homo sapiens_hsa052110.58924352
69Bile secretion_Homo sapiens_hsa049760.57731021
70Ras signaling pathway_Homo sapiens_hsa040140.56505470
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56347286
72mTOR signaling pathway_Homo sapiens_hsa041500.56010023
73Prion diseases_Homo sapiens_hsa050200.55449754
74Endocytosis_Homo sapiens_hsa041440.55098140
75Rap1 signaling pathway_Homo sapiens_hsa040150.55092074
76Glucagon signaling pathway_Homo sapiens_hsa049220.53679572
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52270464
78Endometrial cancer_Homo sapiens_hsa052130.51196493
79Alzheimers disease_Homo sapiens_hsa050100.50875655
80Butanoate metabolism_Homo sapiens_hsa006500.50767364
81AMPK signaling pathway_Homo sapiens_hsa041520.50246999
82Insulin signaling pathway_Homo sapiens_hsa049100.49806211
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46496075
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44360980
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44343169
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44325764
87Non-small cell lung cancer_Homo sapiens_hsa052230.43952510
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43117963
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43068002
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42694137
91Inositol phosphate metabolism_Homo sapiens_hsa005620.41951905
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41349979
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40857139
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40209631
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40028740
96Type I diabetes mellitus_Homo sapiens_hsa049400.39814784
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38805526
98Alcoholism_Homo sapiens_hsa050340.37779101
99Hippo signaling pathway_Homo sapiens_hsa043900.37503897
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35414423
101Prolactin signaling pathway_Homo sapiens_hsa049170.33454347
102Steroid biosynthesis_Homo sapiens_hsa001000.32916652
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32240586
104Phagosome_Homo sapiens_hsa041450.32029874
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31811145
106Wnt signaling pathway_Homo sapiens_hsa043100.30991858
107Fatty acid biosynthesis_Homo sapiens_hsa000610.29662334
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29577386
109Ovarian steroidogenesis_Homo sapiens_hsa049130.29444052
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29210623
111Colorectal cancer_Homo sapiens_hsa052100.29117315
112Circadian rhythm_Homo sapiens_hsa047100.29092505
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.28562406

Most similar genes based on co-expression Upload to Enrichr

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