SLC9A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)4.85880129
2kynurenine metabolic process (GO:0070189)4.45652513
3regulation of hippo signaling (GO:0035330)4.36179765
4positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.29393898
5cellular response to ethanol (GO:0071361)4.20915799
6phospholipid translocation (GO:0045332)4.13743379
7lipid translocation (GO:0034204)4.13743379
8tryptophan catabolic process (GO:0006569)4.13319525
9indole-containing compound catabolic process (GO:0042436)4.13319525
10indolalkylamine catabolic process (GO:0046218)4.13319525
11mitochondrial calcium ion transport (GO:0006851)3.81910178
12negative regulation of cytosolic calcium ion concentration (GO:0051481)3.80545536
13magnesium ion transport (GO:0015693)3.75182089
14tryptophan metabolic process (GO:0006568)3.62003858
15protein K11-linked deubiquitination (GO:0035871)3.61501319
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49115195
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.45903362
18replicative senescence (GO:0090399)3.42600936
19positive regulation of gamma-delta T cell activation (GO:0046645)3.37870577
20L-fucose catabolic process (GO:0042355)3.28338814
21fucose catabolic process (GO:0019317)3.28338814
22L-fucose metabolic process (GO:0042354)3.28338814
23interkinetic nuclear migration (GO:0022027)3.24758403
24insulin secretion (GO:0030073)3.24274690
25cellular response to exogenous dsRNA (GO:0071360)3.23708166
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18573248
27regulation of synaptic vesicle exocytosis (GO:2000300)3.18169233
28indolalkylamine metabolic process (GO:0006586)3.12309778
29behavioral response to nicotine (GO:0035095)3.12054562
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.11405279
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09809236
32detection of calcium ion (GO:0005513)3.06806854
33sphingoid metabolic process (GO:0046519)3.06425436
34locomotory exploration behavior (GO:0035641)3.06412759
35regulation of ARF protein signal transduction (GO:0032012)3.05381130
36import into cell (GO:0098657)3.03688117
37response to pheromone (GO:0019236)3.02817416
38regulation of B cell receptor signaling pathway (GO:0050855)3.00492928
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00213940
40startle response (GO:0001964)2.95687475
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94927632
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91843129
43regulation of alkaline phosphatase activity (GO:0010692)2.91779302
44vitamin transmembrane transport (GO:0035461)2.91202203
45positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.90464393
46Golgi transport vesicle coating (GO:0048200)2.90209898
47COPI coating of Golgi vesicle (GO:0048205)2.90209898
48iron ion import (GO:0097286)2.89405452
49negative regulation of mast cell activation (GO:0033004)2.88635270
50regulation of synaptic vesicle transport (GO:1902803)2.85748905
51regulation of glutamate receptor signaling pathway (GO:1900449)2.85422626
52regulation of protein polyubiquitination (GO:1902914)2.84772578
53snRNA transcription (GO:0009301)2.78425556
54synaptic vesicle docking involved in exocytosis (GO:0016081)2.77396745
55indole-containing compound metabolic process (GO:0042430)2.73852503
56positive regulation of developmental pigmentation (GO:0048087)2.71049472
57histone H3-K36 demethylation (GO:0070544)2.69930000
58endosome to melanosome transport (GO:0035646)2.69272411
59endosome to pigment granule transport (GO:0043485)2.69272411
60regulation of establishment of cell polarity (GO:2000114)2.68087712
61positive regulation by symbiont of host defense response (GO:0052509)2.62016477
62modulation by symbiont of host defense response (GO:0052031)2.62016477
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62016477
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62016477
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.62016477
66modulation by symbiont of host immune response (GO:0052553)2.62016477
67Golgi to endosome transport (GO:0006895)2.61683861
68opioid receptor signaling pathway (GO:0038003)2.61442283
69vocalization behavior (GO:0071625)2.61328692
70mitotic cell cycle arrest (GO:0071850)2.60759878
71serotonin metabolic process (GO:0042428)2.60320807
72sphingosine metabolic process (GO:0006670)2.59097190
73neuron cell-cell adhesion (GO:0007158)2.57855616
74mitochondrial calcium ion homeostasis (GO:0051560)2.56802689
75neural tube formation (GO:0001841)2.56654296
76positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.56512186
77gamma-aminobutyric acid transport (GO:0015812)2.56153092
78B cell receptor signaling pathway (GO:0050853)2.54807652
79synaptic vesicle exocytosis (GO:0016079)2.54672375
80presynaptic membrane assembly (GO:0097105)2.53515044
81diol metabolic process (GO:0034311)2.52327630
82histone H3-K4 trimethylation (GO:0080182)2.51573311
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51289376
84histone H3-K9 methylation (GO:0051567)2.50819961
85ionotropic glutamate receptor signaling pathway (GO:0035235)2.50057938
86organ growth (GO:0035265)2.49937967
87peptidyl-lysine methylation (GO:0018022)2.49848416
88regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.49108659
89protein import into peroxisome matrix (GO:0016558)2.48649294
90regulation of MHC class I biosynthetic process (GO:0045343)2.47748011
91response to auditory stimulus (GO:0010996)2.47271128
92multicellular organism reproduction (GO:0032504)2.46597394
93macroautophagy (GO:0016236)2.45971928
94dicarboxylic acid biosynthetic process (GO:0043650)2.45966312
95cerebellar Purkinje cell differentiation (GO:0021702)2.45316553
96macrophage activation involved in immune response (GO:0002281)2.44368773
97negative regulation of calcium ion transport into cytosol (GO:0010523)2.43966185
98inner ear receptor cell development (GO:0060119)2.42887006
99positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.42111465
100oxidative demethylation (GO:0070989)2.41702620
101T cell lineage commitment (GO:0002360)2.40380158
102synaptic vesicle maturation (GO:0016188)2.40015116
103regulation of pigment cell differentiation (GO:0050932)2.38915556
104pyrimidine-containing compound transmembrane transport (GO:0072531)2.38659711
105synaptic transmission, glutamatergic (GO:0035249)2.38435736
106retrograde transport, vesicle recycling within Golgi (GO:0000301)2.38269401
107protein targeting to Golgi (GO:0000042)2.37565099
108regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.36880167
109positive regulation of protein homooligomerization (GO:0032464)2.36863132
110relaxation of cardiac muscle (GO:0055119)2.36850655
111phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.35817074
112response to host immune response (GO:0052572)2.35419509
113response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.35419509
114synaptic vesicle endocytosis (GO:0048488)2.34577685
115neuronal action potential (GO:0019228)2.34079369
116CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.33399744
117protein targeting to vacuole (GO:0006623)2.33049812
118protein targeting to lysosome (GO:0006622)2.33049812
119establishment of protein localization to vacuole (GO:0072666)2.33049812
120behavioral response to ethanol (GO:0048149)2.32414406
121innervation (GO:0060384)2.31952845
122positive regulation of CREB transcription factor activity (GO:0032793)2.31770844
123calcium ion import (GO:0070509)2.31760748
124chemosensory behavior (GO:0007635)2.31069158
125primary amino compound metabolic process (GO:1901160)2.30594940
126establishment of protein localization to Golgi (GO:0072600)2.30532849
127gene silencing by RNA (GO:0031047)2.30419634
128protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.30012247
129B cell proliferation (GO:0042100)2.28407935
130prenylation (GO:0097354)2.27734554
131protein prenylation (GO:0018342)2.27734554
132membrane depolarization during action potential (GO:0086010)2.27733704
133B cell homeostasis (GO:0001782)2.27660299
134ER overload response (GO:0006983)2.26993874
135positive regulation of synaptic transmission, GABAergic (GO:0032230)2.26960587
136postsynaptic membrane organization (GO:0001941)2.26831284
137regulation of dendritic cell antigen processing and presentation (GO:0002604)2.25791838
138proline transport (GO:0015824)2.24484705
139urinary tract smooth muscle contraction (GO:0014848)2.24201491
140negative regulation of osteoblast proliferation (GO:0033689)2.23801360
141negative regulation of bone resorption (GO:0045779)2.22534625
142glutamate receptor signaling pathway (GO:0007215)2.22272511
143type B pancreatic cell development (GO:0003323)2.21407049
144gamma-aminobutyric acid signaling pathway (GO:0007214)2.20941483
145cellular ketone body metabolic process (GO:0046950)2.20697852
146detection of light stimulus involved in sensory perception (GO:0050962)2.20642247
147peptide secretion (GO:0002790)2.17915376
148cAMP-mediated signaling (GO:0019933)2.17615598
149negative regulation of cell killing (GO:0031342)2.17347589
150negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.17347589
151regulation of NFAT protein import into nucleus (GO:0051532)2.17179996
152negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.16263038
153regulation of exocytosis (GO:0017157)2.15211277
154glutamate secretion (GO:0014047)2.15152780
155intra-Golgi vesicle-mediated transport (GO:0006891)2.14872567
156retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.14860755
157protein localization to synapse (GO:0035418)2.14738792
158peptide hormone secretion (GO:0030072)2.14355147
159exploration behavior (GO:0035640)2.13227075
160negative regulation of glycogen biosynthetic process (GO:0045719)2.12775758
161regulation of neurotransmitter secretion (GO:0046928)2.12656726
162regulation of interferon-beta biosynthetic process (GO:0045357)2.12523747
163positive regulation of exocytosis (GO:0045921)2.12292595
164phosphatidylinositol phosphorylation (GO:0046854)2.11922775
165neurotransmitter secretion (GO:0007269)2.11891848
166glycosphingolipid biosynthetic process (GO:0006688)2.11270097
167cellular response to ATP (GO:0071318)2.11194551
168regulation of gamma-delta T cell activation (GO:0046643)2.11171731
169vesicle transport along microtubule (GO:0047496)2.10588316
170positive T cell selection (GO:0043368)2.10017972
171regulation of synaptic transmission, glutamatergic (GO:0051966)2.09040539
172neuron-neuron synaptic transmission (GO:0007270)2.08682205
173prostate gland growth (GO:0060736)2.08619702
174regulation of germinal center formation (GO:0002634)2.08561601
175response to host (GO:0075136)2.08014876
176response to host defenses (GO:0052200)2.08014876
177response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.08014876
178negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.07841564
179positive regulation of regulated secretory pathway (GO:1903307)2.06720687
180presynaptic membrane organization (GO:0097090)2.06663313
181positive regulation of membrane potential (GO:0045838)2.06448596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.79639549
2EZH2_22144423_ChIP-Seq_EOC_Human3.53696368
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.78520348
4ZNF274_21170338_ChIP-Seq_K562_Hela2.60638433
5IGF1R_20145208_ChIP-Seq_DFB_Human2.49014248
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.28236018
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20662964
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20499466
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16796180
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.13208373
11* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01894727
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99493166
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99183573
14TP53_16413492_ChIP-PET_HCT116_Human1.94879326
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94071213
16SMAD4_21799915_ChIP-Seq_A2780_Human1.82575040
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80078824
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76985556
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.71838584
20DROSHA_22980978_ChIP-Seq_HELA_Human1.68807593
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67609187
22* STAT3_23295773_ChIP-Seq_U87_Human1.65317217
23* REST_21632747_ChIP-Seq_MESCs_Mouse1.64878113
24EWS_26573619_Chip-Seq_HEK293_Human1.63491975
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63338400
26P300_19829295_ChIP-Seq_ESCs_Human1.62190437
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.59673251
28* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59045446
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58577174
30FUS_26573619_Chip-Seq_HEK293_Human1.57310985
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.55949013
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55620008
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.53496434
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52926135
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52825118
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52626865
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49187460
38CTNNB1_20460455_ChIP-Seq_HCT116_Human1.47503595
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47146618
40TCF4_23295773_ChIP-Seq_U87_Human1.44081200
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.41901266
42AR_25329375_ChIP-Seq_VCAP_Human1.41121147
43* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40240000
44GATA1_22025678_ChIP-Seq_K562_Human1.40162800
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.38278566
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37878363
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37866482
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37698333
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36741417
50BRD4_25478319_ChIP-Seq_HGPS_Human1.36007529
51* ARNT_22903824_ChIP-Seq_MCF-7_Human1.35517028
52P53_22387025_ChIP-Seq_ESCs_Mouse1.34907661
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34835800
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34835800
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.34657823
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33934337
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.30841244
58* AHR_22903824_ChIP-Seq_MCF-7_Human1.30584343
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30255375
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30215423
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.29483035
62AR_21572438_ChIP-Seq_LNCaP_Human1.28921860
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28675778
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28132349
65RUNX_20019798_ChIP-Seq_JUKART_Human1.28032024
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.27350611
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.27095350
68VDR_22108803_ChIP-Seq_LS180_Human1.26680664
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25689507
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24670266
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.24255228
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.23625175
73* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23595799
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.23326352
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22601728
76TAF15_26573619_Chip-Seq_HEK293_Human1.22491830
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.22286399
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22277881
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20988292
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.20595611
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.20184587
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.19948428
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19706607
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19508307
85RUNX2_22187159_ChIP-Seq_PCA_Human1.19491821
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19087067
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.18754972
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18301866
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17645756
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.17356227
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17215767
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15559315
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15285799
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.14980215
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14402513
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.14357636
97CBP_20019798_ChIP-Seq_JUKART_Human1.13738720
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13738720
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13630244
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12845700
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12563671
102* CJUN_26792858_Chip-Seq_BT549_Human1.12001916
103AR_19668381_ChIP-Seq_PC3_Human1.11570721
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11415392
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11415392
106RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11200667
107EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11200667
108ER_23166858_ChIP-Seq_MCF-7_Human1.10103540
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09770361
110PU1_27457419_Chip-Seq_LIVER_Mouse1.09753075
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09138407
112P300_18555785_Chip-Seq_ESCs_Mouse1.08560372
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08323786
114EED_16625203_ChIP-ChIP_MESCs_Mouse1.08093157
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07904771
116BCAT_22108803_ChIP-Seq_LS180_Human1.07838331
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06815018
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06743932
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05450196
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04978970
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04608065
122SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04401600
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03678910
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02805389
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02669030
126CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02516459
127RARB_27405468_Chip-Seq_BRAIN_Mouse1.02281250
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.02124475
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.01208889
130CDX2_22108803_ChIP-Seq_LS180_Human0.99518214
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.98960314
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98878277
133TP53_18474530_ChIP-ChIP_U2OS_Human0.98597043
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.97712287
135JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96998094
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.95510766
137* TP63_23658742_ChIP-Seq_EP156T_Human0.95169770
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94407722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.89700433
2MP0003183_abnormal_peptide_metabolism3.21820950
3MP0005645_abnormal_hypothalamus_physiol3.20179207
4MP0005646_abnormal_pituitary_gland3.04367268
5MP0003787_abnormal_imprinting2.93360713
6MP0002909_abnormal_adrenal_gland2.65658718
7MP0001835_abnormal_antigen_presentation2.50871313
8MP0004859_abnormal_synaptic_plasticity2.49470064
9MP0000427_abnormal_hair_cycle2.41723911
10MP0005310_abnormal_salivary_gland2.39039288
11MP0008057_abnormal_DNA_replication2.33004635
12MP0003172_abnormal_lysosome_physiology2.31827449
13MP0001986_abnormal_taste_sensitivity2.29707503
14MP0010386_abnormal_urinary_bladder2.28462500
15MP0009780_abnormal_chondrocyte_physiolo2.20776324
16MP0000383_abnormal_hair_follicle2.18598740
17MP0002693_abnormal_pancreas_physiology2.17554185
18MP0001188_hyperpigmentation2.02567711
19MP0003635_abnormal_synaptic_transmissio1.96618727
20MP0005379_endocrine/exocrine_gland_phen1.95560695
21MP0001790_abnormal_immune_system1.87659174
22MP0005387_immune_system_phenotype1.87659174
23MP0002735_abnormal_chemical_nociception1.85044099
24MP0002877_abnormal_melanocyte_morpholog1.80583459
25MP0001502_abnormal_circadian_rhythm1.77110574
26MP0009046_muscle_twitch1.76114249
27MP0002876_abnormal_thyroid_physiology1.75663399
28MP0001968_abnormal_touch/_nociception1.74283717
29MP0010678_abnormal_skin_adnexa1.69719461
30MP0010352_gastrointestinal_tract_polyps1.68713966
31MP0000015_abnormal_ear_pigmentation1.68508418
32MP0002063_abnormal_learning/memory/cond1.65834011
33MP0002572_abnormal_emotion/affect_behav1.65377385
34MP0001348_abnormal_lacrimal_gland1.60538525
35MP0001800_abnormal_humoral_immune1.59799081
36MP0003252_abnormal_bile_duct1.58933854
37MP0003045_fibrosis1.58693711
38MP0004130_abnormal_muscle_cell1.57643806
39MP0004510_myositis1.55840719
40MP0009745_abnormal_behavioral_response1.54484188
41MP0002734_abnormal_mechanical_nocicepti1.54401423
42MP0002736_abnormal_nociception_after1.49747285
43MP0004270_analgesia1.47436270
44MP0001984_abnormal_olfaction1.46150609
45MP0001486_abnormal_startle_reflex1.45754076
46MP0005671_abnormal_response_to1.45442109
47MP0004084_abnormal_cardiac_muscle1.41894882
48MP0008875_abnormal_xenobiotic_pharmacok1.40454534
49MP0006072_abnormal_retinal_apoptosis1.40223760
50MP0001501_abnormal_sleep_pattern1.39663621
51MP0005423_abnormal_somatic_nervous1.38459745
52MP0002064_seizures1.38156883
53MP0003950_abnormal_plasma_membrane1.35733928
54MP0003880_abnormal_central_pattern1.35359812
55MP0003122_maternal_imprinting1.35307195
56MP0008872_abnormal_physiological_respon1.32131409
57MP0002452_abnormal_antigen_presenting1.31660735
58MP0005551_abnormal_eye_electrophysiolog1.29285375
59MP0001944_abnormal_pancreas_morphology1.28412691
60MP0005000_abnormal_immune_tolerance1.27231457
61MP0002067_abnormal_sensory_capabilities1.26623323
62MP0002557_abnormal_social/conspecific_i1.25577830
63MP0004742_abnormal_vestibular_system1.20770723
64MP0003300_gastrointestinal_ulcer1.20553059
65MP0002723_abnormal_immune_serum1.20214730
66MP0002272_abnormal_nervous_system1.18952359
67MP0002254_reproductive_system_inflammat1.18107233
68MP0008569_lethality_at_weaning1.17688856
69MP0002184_abnormal_innervation1.16977021
70MP0003646_muscle_fatigue1.16767811
71MP0002168_other_aberrant_phenotype1.15829984
72MP0003091_abnormal_cell_migration1.12672438
73MP0005174_abnormal_tail_pigmentation1.11788709
74MP0004808_abnormal_hematopoietic_stem1.11309705
75MP0002396_abnormal_hematopoietic_system1.10797603
76MP0003879_abnormal_hair_cell1.10380069
77MP0001819_abnormal_immune_cell1.10170976
78MP0002420_abnormal_adaptive_immunity1.10165398
79MP0008961_abnormal_basal_metabolism1.10028038
80MP0005253_abnormal_eye_physiology1.09600919
81MP0003283_abnormal_digestive_organ1.08867158
82MP0002148_abnormal_hypersensitivity_rea1.07787824
83MP0002928_abnormal_bile_duct1.07179199
84MP0002638_abnormal_pupillary_reflex1.06413266
85MP0005623_abnormal_meninges_morphology1.05767527
86MP0002138_abnormal_hepatobiliary_system1.04712701
87MP0004036_abnormal_muscle_relaxation1.04671793
88MP0001970_abnormal_pain_threshold1.04186099
89MP0002733_abnormal_thermal_nociception1.02464131
90MP0004043_abnormal_pH_regulation1.02266131
91MP0002102_abnormal_ear_morphology1.00450554
92MP0003121_genomic_imprinting1.00172026
93MP0000470_abnormal_stomach_morphology1.00078626
94MP0006276_abnormal_autonomic_nervous0.95184715
95MP0004885_abnormal_endolymph0.95018438
96MP0003631_nervous_system_phenotype0.94883465
97MP0002163_abnormal_gland_morphology0.94300388
98MP0000631_abnormal_neuroendocrine_gland0.92810738
99MP0002160_abnormal_reproductive_system0.92482367
100MP0002419_abnormal_innate_immunity0.92114912
101MP0000685_abnormal_immune_system0.91784605
102MP0002234_abnormal_pharynx_morphology0.91223846
103MP0002009_preneoplasia0.91187561
104MP0000678_abnormal_parathyroid_gland0.90712802
105MP0000538_abnormal_urinary_bladder0.90527196
106MP0000604_amyloidosis0.90271633
107MP0005386_behavior/neurological_phenoty0.88752908
108MP0004924_abnormal_behavior0.88752908
109MP0004811_abnormal_neuron_physiology0.87793402
110MP0008877_abnormal_DNA_methylation0.87166435
111MP0003632_abnormal_nervous_system0.86109057
112MP0006292_abnormal_olfactory_placode0.85789827
113MP0005058_abnormal_lysosome_morphology0.84478280
114MP0002177_abnormal_outer_ear0.83947432
115MP0004134_abnormal_chest_morphology0.83707852
116MP0004233_abnormal_muscle_weight0.83244776
117MP0004145_abnormal_muscle_electrophysio0.82544895
118MP0003763_abnormal_thymus_physiology0.81563220
119MP0002075_abnormal_coat/hair_pigmentati0.81415533
120MP0002398_abnormal_bone_marrow0.80805670
121MP0002006_tumorigenesis0.80390637
122MP0002837_dystrophic_cardiac_calcinosis0.79106540
123MP0005595_abnormal_vascular_smooth0.78296549
124MP0000716_abnormal_immune_system0.78261978
125MP0001299_abnormal_eye_distance/0.77368366
126MP0002166_altered_tumor_susceptibility0.77243527
127MP0004142_abnormal_muscle_tone0.76668274
128MP0002229_neurodegeneration0.75259405
129MP0001873_stomach_inflammation0.75224268
130MP0002332_abnormal_exercise_endurance0.74947158
131MP0002078_abnormal_glucose_homeostasis0.74558933
132MP0005257_abnormal_intraocular_pressure0.74244142
133MP0000013_abnormal_adipose_tissue0.73900751
134MP0000613_abnormal_salivary_gland0.73683173
135MP0008874_decreased_physiological_sensi0.73162673
136MP0001661_extended_life_span0.73134967
137MP0006082_CNS_inflammation0.72985550
138MP0003633_abnormal_nervous_system0.72557574
139MP0000955_abnormal_spinal_cord0.69884490
140MP0001440_abnormal_grooming_behavior0.69569847
141MP0000371_diluted_coat_color0.68687092
142MP0002882_abnormal_neuron_morphology0.67070446
143MP0003866_abnormal_defecation0.66575485

Predicted human phenotypes

RankGene SetZ-score
1Inability to walk (HP:0002540)4.29196242
2Febrile seizures (HP:0002373)4.17391282
3Hyperventilation (HP:0002883)3.90484222
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.75253764
5Pheochromocytoma (HP:0002666)3.67422570
6Focal motor seizures (HP:0011153)3.53262307
7Genetic anticipation (HP:0003743)3.26680049
8Clumsiness (HP:0002312)3.17765760
9Neuroendocrine neoplasm (HP:0100634)3.15518050
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.03961238
11Abnormality of alanine metabolism (HP:0010916)3.03961238
12Hyperalaninemia (HP:0003348)3.03961238
13Pancreatic cysts (HP:0001737)2.98103563
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.90211453
15Short chin (HP:0000331)2.85229264
16Agammaglobulinemia (HP:0004432)2.83497814
17Insulin-resistant diabetes mellitus (HP:0000831)2.80300896
18Symptomatic seizures (HP:0011145)2.75533753
19Congenital stationary night blindness (HP:0007642)2.75503931
20Type II lissencephaly (HP:0007260)2.72776399
21Dysmetric saccades (HP:0000641)2.67838574
22Epileptic encephalopathy (HP:0200134)2.66319472
23Mutism (HP:0002300)2.64323104
24Abnormal hair whorl (HP:0010721)2.61447016
25Fair hair (HP:0002286)2.60259038
26Progressive inability to walk (HP:0002505)2.59938111
27Abnormality of polysaccharide metabolism (HP:0011012)2.58230195
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.58230195
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.58230195
30Focal seizures (HP:0007359)2.55077055
31Hypoglycemic seizures (HP:0002173)2.53600496
32Abnormality of calcium-phosphate metabolism (HP:0100530)2.49152402
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.46396062
34Neoplasm of the peripheral nervous system (HP:0100007)2.44837084
35Papilledema (HP:0001085)2.43352378
36Recurrent cutaneous fungal infections (HP:0011370)2.42177010
37Chronic mucocutaneous candidiasis (HP:0002728)2.42177010
38Urinary bladder sphincter dysfunction (HP:0002839)2.42136338
39Keratoconus (HP:0000563)2.41385605
40Increased corneal curvature (HP:0100692)2.41385605
41Atonic seizures (HP:0010819)2.38793347
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.38777672
43Decreased circulating renin level (HP:0003351)2.36492842
44Urinary glycosaminoglycan excretion (HP:0003541)2.34840380
45Mucopolysacchariduria (HP:0008155)2.34840380
46Attenuation of retinal blood vessels (HP:0007843)2.34205621
47Visual hallucinations (HP:0002367)2.33306570
48Recurrent abscess formation (HP:0002722)2.33147643
49Protruding tongue (HP:0010808)2.32490053
50Morphological abnormality of the pyramidal tract (HP:0002062)2.32134663
51Absence seizures (HP:0002121)2.30089974
52Prostate neoplasm (HP:0100787)2.29579159
53Acute lymphatic leukemia (HP:0006721)2.27168448
54Abnormality of the fingertips (HP:0001211)2.26933138
55Concave nail (HP:0001598)2.26387144
56Dialeptic seizures (HP:0011146)2.21189300
57Cerebellar dysplasia (HP:0007033)2.20897378
58Colitis (HP:0002583)2.20779164
59Gastrointestinal stroma tumor (HP:0100723)2.20135757
60Generalized hypopigmentation of hair (HP:0011358)2.19894583
61Recurrent bacterial skin infections (HP:0005406)2.19706495
62Progressive cerebellar ataxia (HP:0002073)2.18953311
63Global brain atrophy (HP:0002283)2.16926015
64Osteomalacia (HP:0002749)2.16488769
65Conical tooth (HP:0000698)2.15152879
66Capillary hemangiomas (HP:0005306)2.14214612
67Dysostosis multiplex (HP:0000943)2.14206690
68Fibular aplasia (HP:0002990)2.08441075
69Papillary thyroid carcinoma (HP:0002895)2.08079555
70Retrobulbar optic neuritis (HP:0100654)2.07551403
71Optic neuritis (HP:0100653)2.07551403
72Hyperinsulinemic hypoglycemia (HP:0000825)2.06828728
73Hypothermia (HP:0002045)2.06497867
74Diplopia (HP:0000651)2.05313703
75Abnormality of binocular vision (HP:0011514)2.05313703
76Macroglossia (HP:0000158)2.04765466
77Broad-based gait (HP:0002136)2.02777761
78Recurrent fungal infections (HP:0002841)2.00294883
79Hyperglycemia (HP:0003074)1.98335468
80Menstrual irregularities (HP:0000858)1.97278624
81Inflammation of the large intestine (HP:0002037)1.96887713
82Partial agenesis of the corpus callosum (HP:0001338)1.94813547
83Bony spicule pigmentary retinopathy (HP:0007737)1.94699139
84Hypoplasia of the odontoid process (HP:0003311)1.94034320
85Agitation (HP:0000713)1.93573726
86Hyperphosphatemia (HP:0002905)1.93546725
87Action tremor (HP:0002345)1.92930855
88Tubular atrophy (HP:0000092)1.92422009
89Chronic diarrhea (HP:0002028)1.91772411
90Truncal ataxia (HP:0002078)1.86693458
91Failure to thrive in infancy (HP:0001531)1.86167847
92Facial diplegia (HP:0001349)1.86148120
93Drooling (HP:0002307)1.84810040
94Excessive salivation (HP:0003781)1.84810040
95Hamartoma of the eye (HP:0010568)1.84510229
96Epileptiform EEG discharges (HP:0011182)1.83981158
97Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.82878288
98Short 1st metacarpal (HP:0010034)1.82878288
99Meningitis (HP:0001287)1.81612598
100Submucous cleft hard palate (HP:0000176)1.81512373
101Generalized tonic-clonic seizures (HP:0002069)1.81298875
102Chronic hepatic failure (HP:0100626)1.81211467
103Abnormal rod and cone electroretinograms (HP:0008323)1.80764204
104Increased cerebral lipofuscin (HP:0011813)1.80650488
105Recurrent viral infections (HP:0004429)1.79927468
106Impaired smooth pursuit (HP:0007772)1.79313356
107Absent speech (HP:0001344)1.77911618
108Syringomyelia (HP:0003396)1.77710120
109Spinal cord lesions (HP:0100561)1.77710120
110Neoplasm of the adrenal cortex (HP:0100641)1.77706750
111EEG with generalized epileptiform discharges (HP:0011198)1.76923490
112Meningioma (HP:0002858)1.76715646
113Prominent nose (HP:0000448)1.75497748
114Retinal atrophy (HP:0001105)1.75231552
115Tinnitus (HP:0000360)1.74637820
116Lip pit (HP:0100267)1.74629354
117Lymphopenia (HP:0001888)1.74259467
118Spastic paraplegia (HP:0001258)1.73929095
119Abnormality of liposaccharide metabolism (HP:0010968)1.73742844
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.73742844
121Abnormality of glycolipid metabolism (HP:0010969)1.73742844
122Vasculitis (HP:0002633)1.73631016
123Mediastinal lymphadenopathy (HP:0100721)1.73459057
124Eczematoid dermatitis (HP:0000976)1.73386238
125Ureteral obstruction (HP:0006000)1.72532284
126Pulmonary infiltrates (HP:0002113)1.72291717
127Megalocornea (HP:0000485)1.71811259
128Abnormality of B cell number (HP:0010975)1.71445969
129Fatigue (HP:0012378)1.71172195
130Villous atrophy (HP:0011473)1.71047504
131Abnormality of small intestinal villus morphology (HP:0011472)1.71047504
132Gastrointestinal inflammation (HP:0004386)1.70680989
133Paraplegia (HP:0010550)1.70433399
134Flat cornea (HP:0007720)1.70274713
135Broad ribs (HP:0000885)1.69645987
136Macroorchidism (HP:0000053)1.69545361
137Hypoplasia of the fovea (HP:0007750)1.69030489
138Aplasia/Hypoplasia of the fovea (HP:0008060)1.69030489
139Confusion (HP:0001289)1.68947745
140Dysdiadochokinesis (HP:0002075)1.68518047
141Widely spaced teeth (HP:0000687)1.67642515
142Central scotoma (HP:0000603)1.67601872
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67595578
144Hip dysplasia (HP:0001385)1.67443221
145Curly hair (HP:0002212)1.66436045
146IgA deficiency (HP:0002720)1.65741098
147Gaze-evoked nystagmus (HP:0000640)1.65501280
148Abnormality of the renal cortex (HP:0011035)1.65481839
149Congenital sensorineural hearing impairment (HP:0008527)1.65203273
150Poor eye contact (HP:0000817)1.64547485
151B lymphocytopenia (HP:0010976)1.64311330
152Asymmetry of the thorax (HP:0001555)1.64189389
153Pendular nystagmus (HP:0012043)1.63905443
154Decreased central vision (HP:0007663)1.63787677
155Abnormality of the nasal septum (HP:0000419)1.63678442
156Impaired vibratory sensation (HP:0002495)1.63214750
157J-shaped sella turcica (HP:0002680)1.63113674
158Gait imbalance (HP:0002141)1.62846024
159Deformed sella turcica (HP:0002681)1.62660624
160Disproportionate short-trunk short stature (HP:0003521)1.62563783
161Abnormality of salivation (HP:0100755)1.62427662
162Cubitus valgus (HP:0002967)1.61983664
163Ketoacidosis (HP:0001993)1.61268543
164Nephronophthisis (HP:0000090)1.60522919
165Nephrogenic diabetes insipidus (HP:0009806)1.60041990
166Ureteral stenosis (HP:0000071)1.60025293
167Inappropriate behavior (HP:0000719)1.59809112
168Abnormality of ocular smooth pursuit (HP:0000617)1.59420788
169Hypsarrhythmia (HP:0002521)1.58877361
170Restrictive lung disease (HP:0002091)1.58398963
171Medial flaring of the eyebrow (HP:0010747)1.58209992
172Abnormality of macular pigmentation (HP:0008002)1.58136988
173Follicular hyperkeratosis (HP:0007502)1.58061504
174Chorioretinal atrophy (HP:0000533)1.57839804
175Dyschromatopsia (HP:0007641)1.57398291
176Abnormality of cells of the lymphoid lineage (HP:0012140)1.56921866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.28076769
2EIF2AK33.56217970
3NTRK33.31986898
4PINK13.23635320
5CASK3.18972275
6TAOK32.64416199
7MAP4K22.60678010
8BLK2.40448885
9NEK92.36996017
10FRK2.34514267
11MAP3K142.30319904
12SGK22.18302350
13MAP2K72.11385357
14RIPK42.06365971
15BMPR22.05599453
16AKT31.97635226
17SIK31.96445119
18JAK11.85339970
19IRAK31.84410355
20SGK31.74899178
21TAF11.73638265
22PHKG21.69782341
23PHKG11.69782341
24MAPK151.65939723
25MAP3K131.64077353
26MAP3K41.63726517
27TRPM71.63101754
28EEF2K1.59303249
29STK31.56750105
30PASK1.54939121
31MAPK131.51193099
32IRAK41.45570739
33HIPK21.44104024
34MARK11.38008194
35NTRK21.36342856
36GRK71.32827792
37STK38L1.27683539
38MAP4K11.24484318
39PRPF4B1.18106096
40SYK1.16368774
41SGK4941.14859589
42SGK2231.14859589
43DAPK21.13783432
44CDK121.11475766
45NEK61.08543739
46CAMK1G1.07735479
47CDC42BPA1.07279737
48SCYL21.04591932
49LATS11.04448516
50PRKCH1.04304888
51FGFR31.03576490
52ERBB31.03507436
53TNK21.00720705
54MAPKAPK31.00273840
55PDGFRB0.99984131
56SIK20.99542233
57TXK0.97589868
58MAP3K90.95555727
59MELK0.95247368
60JAK30.94285871
61TNIK0.93698496
62CAMKK20.93450796
63TYK20.93391642
64NUAK10.92817230
65CAMK1D0.91241892
66WNK40.89872011
67CHUK0.89632866
68PAK60.88892034
69ZAK0.86760404
70IKBKB0.86086380
71STK240.83029760
72CSF1R0.81919240
73ITK0.81884092
74MAP3K20.80871605
75CDK30.80651720
76CAMKK10.77962832
77STK390.77806788
78MAPKAPK50.77260544
79SGK10.75650912
80GRK10.75611679
81IKBKE0.75537286
82ADRBK10.75162564
83TEC0.74834884
84ADRBK20.74122264
85BRD40.71756644
86MAPK110.71679396
87MAPK70.70617666
88IRAK10.68154626
89STK110.66108420
90RPS6KB10.65879374
91WNK10.65590917
92EIF2AK20.65270238
93PLK20.63969252
94EPHA30.63832602
95TAOK20.63591032
96FLT30.63047128
97CAMK10.62959352
98YES10.62635560
99PAK30.61807169
100TRIB30.60500758
101PRKCE0.60064795
102PRKCI0.59834137
103CSNK1A1L0.59458211
104CDK50.59163915
105RPS6KA20.59046536
106ACVR1B0.57854336
107TLK10.57180611
108CHEK20.56891476
109MINK10.56567993
110PRKCZ0.54520051
111PRKAA10.53676996
112PIK3CA0.53410991
113FES0.53269922
114HCK0.53039375
115CSNK1D0.52705671
116BTK0.51974717
117MAP3K50.51807043
118BMPR1B0.50506930
119LYN0.50269732
120PRKCQ0.49937319
121JAK20.49665581
122PTK2B0.48915873
123PDGFRA0.46920905
124GRK50.46647367
125PDPK10.46065512
126MAP2K10.45720451
127PRKD20.45553839
128OXSR10.45205726
129MAPK120.44847591
130KIT0.44643324
131RPS6KA60.44577205
132STK380.44330618
133DAPK10.44209221
134TGFBR20.43821135
135PKN10.42484172
136PRKCG0.42163156
137MAPK100.40795049
138ABL10.40355818
139IRAK20.38664376
140PIK3CG0.37631221
141PRKD30.37557175
142CCNB10.36664093
143PDK10.36232536
144TGFBR10.36060377
145CAMK2A0.34897982
146PRKCB0.34692736
147CAMK40.34113970

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002322.66597581
2Insulin secretion_Homo sapiens_hsa049112.22623066
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.13529143
4Nicotine addiction_Homo sapiens_hsa050332.02294418
5Type II diabetes mellitus_Homo sapiens_hsa049302.00780186
6Olfactory transduction_Homo sapiens_hsa047401.92594162
7Asthma_Homo sapiens_hsa053101.85631167
8Synaptic vesicle cycle_Homo sapiens_hsa047211.85369719
9Selenocompound metabolism_Homo sapiens_hsa004501.75470267
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69315278
11Morphine addiction_Homo sapiens_hsa050321.68204990
12Type I diabetes mellitus_Homo sapiens_hsa049401.64441663
13Circadian entrainment_Homo sapiens_hsa047131.63923942
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52951421
15Allograft rejection_Homo sapiens_hsa053301.47128926
16Amphetamine addiction_Homo sapiens_hsa050311.42459431
17Long-term potentiation_Homo sapiens_hsa047201.41350125
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38837818
19Taste transduction_Homo sapiens_hsa047421.38472419
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37764563
21Glutamatergic synapse_Homo sapiens_hsa047241.37060291
22GABAergic synapse_Homo sapiens_hsa047271.36869215
23Phototransduction_Homo sapiens_hsa047441.36084112
24B cell receptor signaling pathway_Homo sapiens_hsa046621.34761160
25Cholinergic synapse_Homo sapiens_hsa047251.30963520
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25007089
27Autoimmune thyroid disease_Homo sapiens_hsa053201.24668184
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23968098
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.22441383
30Serotonergic synapse_Homo sapiens_hsa047261.20701857
31Cocaine addiction_Homo sapiens_hsa050301.19783980
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.18649426
33Dopaminergic synapse_Homo sapiens_hsa047281.16965266
34Salivary secretion_Homo sapiens_hsa049701.12784540
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12216366
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08803983
37Primary immunodeficiency_Homo sapiens_hsa053401.08236044
38Osteoclast differentiation_Homo sapiens_hsa043801.06271407
39Renin secretion_Homo sapiens_hsa049241.05620945
40Circadian rhythm_Homo sapiens_hsa047101.04161084
41Calcium signaling pathway_Homo sapiens_hsa040201.03617570
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01002857
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99954518
44Chemokine signaling pathway_Homo sapiens_hsa040620.99615752
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99562657
46Vibrio cholerae infection_Homo sapiens_hsa051100.99145355
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96925517
48Inositol phosphate metabolism_Homo sapiens_hsa005620.96469301
49Lysine degradation_Homo sapiens_hsa003100.94408198
50Oxytocin signaling pathway_Homo sapiens_hsa049210.94213805
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94106729
52Platelet activation_Homo sapiens_hsa046110.93304344
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92442026
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92347372
55Renal cell carcinoma_Homo sapiens_hsa052110.92160865
56Melanoma_Homo sapiens_hsa052180.90972454
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90851044
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90715294
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.90550921
60Prolactin signaling pathway_Homo sapiens_hsa049170.90313418
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87507703
62cAMP signaling pathway_Homo sapiens_hsa040240.87033193
63Lysosome_Homo sapiens_hsa041420.87030460
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86484218
65GnRH signaling pathway_Homo sapiens_hsa049120.85707920
66Tuberculosis_Homo sapiens_hsa051520.85352301
67Graft-versus-host disease_Homo sapiens_hsa053320.84218402
68Leishmaniasis_Homo sapiens_hsa051400.83819617
69TNF signaling pathway_Homo sapiens_hsa046680.83404366
70Collecting duct acid secretion_Homo sapiens_hsa049660.83189865
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83068760
72Long-term depression_Homo sapiens_hsa047300.82625831
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.81369251
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.81177368
75ErbB signaling pathway_Homo sapiens_hsa040120.80711907
76MAPK signaling pathway_Homo sapiens_hsa040100.80354041
77Nitrogen metabolism_Homo sapiens_hsa009100.79266261
78Hematopoietic cell lineage_Homo sapiens_hsa046400.78081783
79Ether lipid metabolism_Homo sapiens_hsa005650.77314440
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77045027
81Pancreatic secretion_Homo sapiens_hsa049720.76915015
82ABC transporters_Homo sapiens_hsa020100.76737534
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76618137
84Glioma_Homo sapiens_hsa052140.76284835
85Rheumatoid arthritis_Homo sapiens_hsa053230.76128992
86T cell receptor signaling pathway_Homo sapiens_hsa046600.75894097
87Protein export_Homo sapiens_hsa030600.75071781
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74717465
89Other glycan degradation_Homo sapiens_hsa005110.74423257
90Systemic lupus erythematosus_Homo sapiens_hsa053220.72699792
91N-Glycan biosynthesis_Homo sapiens_hsa005100.72605414
92Gastric acid secretion_Homo sapiens_hsa049710.72529263
93Endometrial cancer_Homo sapiens_hsa052130.71910137
94Toxoplasmosis_Homo sapiens_hsa051450.71839426
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71798549
96Influenza A_Homo sapiens_hsa051640.70429817
97Measles_Homo sapiens_hsa051620.70164138
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70159157
99Estrogen signaling pathway_Homo sapiens_hsa049150.70154812
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69337773
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68777574
102Basal transcription factors_Homo sapiens_hsa030220.66488147
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.64475823
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.64080887
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62421696
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62368764
107Pancreatic cancer_Homo sapiens_hsa052120.61962648
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61941250
109Sphingolipid metabolism_Homo sapiens_hsa006000.61420385
110mTOR signaling pathway_Homo sapiens_hsa041500.59953426
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59031743
112African trypanosomiasis_Homo sapiens_hsa051430.57041519
113Choline metabolism in cancer_Homo sapiens_hsa052310.56999469
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56907668
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55727872
116FoxO signaling pathway_Homo sapiens_hsa040680.55207389
117Thyroid hormone synthesis_Homo sapiens_hsa049180.54936665
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.54817130
119VEGF signaling pathway_Homo sapiens_hsa043700.54511958
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.54173743
121Dorso-ventral axis formation_Homo sapiens_hsa043200.53692774
122TGF-beta signaling pathway_Homo sapiens_hsa043500.52164161
123Glucagon signaling pathway_Homo sapiens_hsa049220.52014994
124Tryptophan metabolism_Homo sapiens_hsa003800.51984413
125Chronic myeloid leukemia_Homo sapiens_hsa052200.50849538

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