ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingosine metabolic process (GO:0006670)	5.79299287
2	diol metabolic process (GO:0034311)	5.62629762
3	sphingoid metabolic process (GO:0046519)	5.09404461
4	behavioral response to nicotine (GO:0035095)	4.84843426
5	indolalkylamine metabolic process (GO:0006586)	3.91840711
6	DNA methylation involved in gamete generation (GO:0043046)	3.84120644
7	indole-containing compound catabolic process (GO:0042436)	3.80918182
8	indolalkylamine catabolic process (GO:0046218)	3.80918182
9	tryptophan catabolic process (GO:0006569)	3.80918182
10	regulation of meiosis I (GO:0060631)	3.73221357
11	piRNA metabolic process (GO:0034587)	3.69123872
12	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	3.66819953
13	serotonin metabolic process (GO:0042428)	3.41486623
14	DNA deamination (GO:0045006)	3.33717043
15	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.33419982
16	tryptophan metabolic process (GO:0006568)	3.27461164
17	protein-chromophore linkage (GO:0018298)	3.25188934
18	primary amino compound metabolic process (GO:1901160)	3.23753379
19	L-fucose metabolic process (GO:0042354)	3.22220391
20	L-fucose catabolic process (GO:0042355)	3.22220391
21	fucose catabolic process (GO:0019317)	3.22220391
22	kynurenine metabolic process (GO:0070189)	3.18255540
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.17803579
24	rhodopsin mediated signaling pathway (GO:0016056)	3.15940475
25	indole-containing compound metabolic process (GO:0042430)	3.12203241
26	serotonin receptor signaling pathway (GO:0007210)	3.09058486
27	platelet dense granule organization (GO:0060155)	3.02958629
28	somite rostral/caudal axis specification (GO:0032525)	3.01805448
29	negative regulation of mast cell activation (GO:0033004)	3.01456701
30	adaptation of signaling pathway (GO:0023058)	3.00614007
31	negative regulation of interleukin-1 beta production (GO:0032691)	3.00431262
32	tachykinin receptor signaling pathway (GO:0007217)	2.99944492
33	positive regulation of meiosis (GO:0045836)	2.99740996
34	sulfate transmembrane transport (GO:1902358)	2.92780055
35	negative regulation of interleukin-1 production (GO:0032692)	2.91948727
36	sulfation (GO:0051923)	2.89176547
37	cellular response to ATP (GO:0071318)	2.84604811
38	detection of light stimulus involved in visual perception (GO:0050908)	2.83675545
39	detection of light stimulus involved in sensory perception (GO:0050962)	2.83675545
40	regulation of pigment cell differentiation (GO:0050932)	2.78731137
41	amine catabolic process (GO:0009310)	2.77840861
42	cellular biogenic amine catabolic process (GO:0042402)	2.77840861
43	positive regulation of prostaglandin secretion (GO:0032308)	2.77074395
44	regulation of heat generation (GO:0031650)	2.72939023
45	positive regulation of meiotic cell cycle (GO:0051446)	2.72414884
46	negative regulation of telomere maintenance (GO:0032205)	2.72372386
47	superoxide anion generation (GO:0042554)	2.71011116
48	aromatic amino acid family catabolic process (GO:0009074)	2.70639854
49	RNA destabilization (GO:0050779)	2.67968711
50	regulation of protein glycosylation (GO:0060049)	2.67344237
51	axoneme assembly (GO:0035082)	2.65649827
52	organelle disassembly (GO:1903008)	2.65020058
53	centriole replication (GO:0007099)	2.62814276
54	preassembly of GPI anchor in ER membrane (GO:0016254)	2.59721050
55	proline transport (GO:0015824)	2.59134706
56	response to pheromone (GO:0019236)	2.58453317
57	positive regulation of developmental pigmentation (GO:0048087)	2.57811689
58	regulation of hexokinase activity (GO:1903299)	2.56516752
59	regulation of glucokinase activity (GO:0033131)	2.56516752
60	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.56252691
61	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.53927044
62	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.53927044
63	NADH dehydrogenase complex assembly (GO:0010257)	2.53927044
64	ribonucleoprotein complex disassembly (GO:0032988)	2.51627323
65	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.50918555
66	sulfate transport (GO:0008272)	2.50105774
67	positive regulation of T-helper 1 type immune response (GO:0002827)	2.49985976
68	heme transport (GO:0015886)	2.48777025
69	positive regulation of defense response to virus by host (GO:0002230)	2.48712023
70	synaptic transmission, cholinergic (GO:0007271)	2.48649912
71	protein complex biogenesis (GO:0070271)	2.47697494
72	regulation of action potential (GO:0098900)	2.47021550
73	neural tube formation (GO:0001841)	2.46893280
74	mannosylation (GO:0097502)	2.46390484
75	somite development (GO:0061053)	2.45193734
76	positive regulation of heat generation (GO:0031652)	2.44495988
77	regulation of sarcomere organization (GO:0060297)	2.41806212
78	positive regulation of mast cell activation (GO:0033005)	2.40075525
79	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.39153855
80	sequestering of actin monomers (GO:0042989)	2.36505021
81	neuronal action potential (GO:0019228)	2.35589960
82	regulation of memory T cell differentiation (GO:0043380)	2.34314854
83	positive regulation of fatty acid transport (GO:2000193)	2.31932598
84	alanine transport (GO:0032328)	2.31228150
85	aromatic amino acid family metabolic process (GO:0009072)	2.27911047
86	hydrogen peroxide biosynthetic process (GO:0050665)	2.27311472
87	kidney morphogenesis (GO:0060993)	2.26857896
88	toxin metabolic process (GO:0009404)	2.26827830
89	epithelial cilium movement (GO:0003351)	2.26665867
90	microglial cell activation (GO:0001774)	2.25422034
91	glycerol metabolic process (GO:0006071)	2.25353401
92	pyrimidine nucleobase catabolic process (GO:0006208)	2.25269010
93	behavioral response to ethanol (GO:0048149)	2.24150417
94	gamma-aminobutyric acid transport (GO:0015812)	2.23317189
95	benzene-containing compound metabolic process (GO:0042537)	2.22401357
96	mitochondrial respiratory chain complex assembly (GO:0033108)	2.22090531
97	NAD biosynthetic process (GO:0009435)	2.20075003
98	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.16309634
99	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.15679712
100	endocrine pancreas development (GO:0031018)	2.15176046

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.24497512
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.95106982
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.76871400
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.69045000
5	VDR_22108803_ChIP-Seq_LS180_Human	2.65158054
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52135249
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50275089
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.48959720
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.22439780
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15238545
11	P300_19829295_ChIP-Seq_ESCs_Human	2.10678759
12	AR_21572438_ChIP-Seq_LNCaP_Human	2.04276228
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.95109036
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94945592
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.89067021
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.83538100
17	TAF15_26573619_Chip-Seq_HEK293_Human	1.76888041
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.75348800
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75058442
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70165558
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.68119418
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68119418
23	FUS_26573619_Chip-Seq_HEK293_Human	1.66917523
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64813075
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64093118
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57914307
27	EWS_26573619_Chip-Seq_HEK293_Human	1.54698696
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51010679
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48792960
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47932537
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47593108
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47363507
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47182109
34	AR_25329375_ChIP-Seq_VCAP_Human	1.46759930
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.46085738
36	NANOG_19829295_ChIP-Seq_ESCs_Human	1.46085738
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43444828
38	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.43173371
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42516404
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41471760
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.40696421
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37505225
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.37505225
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35768874
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35593847
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35192019
47	STAT3_23295773_ChIP-Seq_U87_Human	1.34890536
48	TCF4_23295773_ChIP-Seq_U87_Human	1.32428261
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32206062
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32018993
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.28680134
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28559219
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27808522
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27006516
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.24919832
56	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24915555
57	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.24540207
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.24101036
59	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.24071017
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.23382665
61	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.22716273
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21805270
63	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21386569
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20506618
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20506618
66	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.20253964
67	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.19856624
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19122964
69	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.17467408
70	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16655512
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.16622507
72	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.15670640
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15051852
74	NCOR_22424771_ChIP-Seq_293T_Human	1.14579124
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.14444427
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13393074
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13036904
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.12752330
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11466295
80	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10802405
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10366044
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10037467
83	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09245509
84	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.08160523
85	AR_20517297_ChIP-Seq_VCAP_Human	1.07738513
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.06826411
87	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.06637756
88	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06069207
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05640677
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05065421
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03365319
92	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03307072
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02763377
94	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.02395883
95	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02055939
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01939478
97	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.01879883
98	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.00525248
99	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.99171827
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97539974

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	5.77733708
2	MP0003136_yellow_coat_color	5.56304808
3	MP0000569_abnormal_digit_pigmentation	4.39192605
4	MP0002653_abnormal_ependyma_morphology	4.01732377
5	MP0005171_absent_coat_pigmentation	3.65614092
6	MP0003195_calcinosis	2.66901701
7	MP0003011_delayed_dark_adaptation	2.47731590
8	MP0002277_abnormal_respiratory_mucosa	2.16490945
9	MP0003045_fibrosis	2.11299035
10	MP0003646_muscle_fatigue	2.10851843
11	MP0003890_abnormal_embryonic-extraembry	1.95177038
12	MP0002938_white_spotting	1.94027415
13	MP0003724_increased_susceptibility_to	1.91132782
14	MP0005174_abnormal_tail_pigmentation	1.87088403
15	MP0001968_abnormal_touch/_nociception	1.83061092
16	MP0002928_abnormal_bile_duct	1.80741700
17	MP0005551_abnormal_eye_electrophysiolog	1.71767328
18	MP0001501_abnormal_sleep_pattern	1.70582995
19	MP0002102_abnormal_ear_morphology	1.68985069
20	MP0002138_abnormal_hepatobiliary_system	1.61621140
21	MP0009745_abnormal_behavioral_response	1.58120669
22	MP0004885_abnormal_endolymph	1.57741766
23	MP0005084_abnormal_gallbladder_morpholo	1.53704378
24	MP0005075_abnormal_melanosome_morpholog	1.53482065
25	MP0002736_abnormal_nociception_after	1.52433280
26	MP0005085_abnormal_gallbladder_physiolo	1.44655507
27	MP0001486_abnormal_startle_reflex	1.42070737
28	MP0008875_abnormal_xenobiotic_pharmacok	1.41529100
29	MP0008877_abnormal_DNA_methylation	1.40247533
30	MP0005646_abnormal_pituitary_gland	1.39990180
31	MP0006292_abnormal_olfactory_placode	1.39088018
32	MP0008872_abnormal_physiological_respon	1.38383615
33	MP0004142_abnormal_muscle_tone	1.36882061
34	MP0004742_abnormal_vestibular_system	1.32758421
35	MP0003879_abnormal_hair_cell	1.30048417
36	MP0002272_abnormal_nervous_system	1.28256949
37	MP0005253_abnormal_eye_physiology	1.27695633
38	MP0002735_abnormal_chemical_nociception	1.26518038
39	MP0004381_abnormal_hair_follicle	1.25868117
40	MP0006072_abnormal_retinal_apoptosis	1.25327447
41	MP0004147_increased_porphyrin_level	1.24270711
42	MP0002148_abnormal_hypersensitivity_rea	1.22321415
43	MP0009764_decreased_sensitivity_to	1.19736186
44	MP0005167_abnormal_blood-brain_barrier	1.19360544
45	MP0002095_abnormal_skin_pigmentation	1.19161691
46	MP0001986_abnormal_taste_sensitivity	1.19081099
47	MP0000427_abnormal_hair_cycle	1.18324190
48	MP0001485_abnormal_pinna_reflex	1.17823444
49	MP0002733_abnormal_thermal_nociception	1.12985417
50	MP0009046_muscle_twitch	1.11020824
51	MP0001970_abnormal_pain_threshold	1.09364719
52	MP0005671_abnormal_response_to	1.09171370
53	MP0005365_abnormal_bile_salt	1.08967634
54	MP0002064_seizures	1.07822242
55	MP0003880_abnormal_central_pattern	1.06883478
56	MP0004133_heterotaxia	1.06253084
57	MP0002572_abnormal_emotion/affect_behav	1.05983052
58	MP0001835_abnormal_antigen_presentation	1.05790534
59	MP0009785_altered_susceptibility_to	1.04506417
60	MP0002638_abnormal_pupillary_reflex	1.03031634
61	MP0001984_abnormal_olfaction	1.01613902
62	MP0001800_abnormal_humoral_immune	0.99381724
63	MP0001324_abnormal_eye_pigmentation	0.99000758
64	MP0003252_abnormal_bile_duct	0.98276089
65	MP0005377_hearing/vestibular/ear_phenot	0.96913509
66	MP0003878_abnormal_ear_physiology	0.96913509
67	MP0004043_abnormal_pH_regulation	0.95826656
68	MP0003436_decreased_susceptibility_to	0.95218890
69	MP0000372_irregular_coat_pigmentation	0.93679388
70	MP0005387_immune_system_phenotype	0.92551575
71	MP0001790_abnormal_immune_system	0.92551575
72	MP0003787_abnormal_imprinting	0.91061318
73	MP0000230_abnormal_systemic_arterial	0.90083170
74	MP0003950_abnormal_plasma_membrane	0.89316106
75	MP0000685_abnormal_immune_system	0.88233210
76	MP0002067_abnormal_sensory_capabilities	0.85182752
77	MP0002419_abnormal_innate_immunity	0.81470146
78	MP0002723_abnormal_immune_serum	0.81146656
79	MP0003137_abnormal_impulse_conducting	0.80782540
80	MP0001529_abnormal_vocalization	0.78597822
81	MP0005389_reproductive_system_phenotype	0.78313174
82	MP0002452_abnormal_antigen_presenting	0.76939216
83	MP0006276_abnormal_autonomic_nervous	0.76709437
84	MP0002876_abnormal_thyroid_physiology	0.75549936
85	MP0005000_abnormal_immune_tolerance	0.73541103
86	MP0000631_abnormal_neuroendocrine_gland	0.73297961
87	MP0002168_other_aberrant_phenotype	0.72988759
88	MP0000026_abnormal_inner_ear	0.72578841
89	MP0000383_abnormal_hair_follicle	0.72209248
90	MP0001905_abnormal_dopamine_level	0.71342110
91	MP0001533_abnormal_skeleton_physiology	0.70135908
92	MP0004924_abnormal_behavior	0.68700200
93	MP0005386_behavior/neurological_phenoty	0.68700200
94	MP0003635_abnormal_synaptic_transmissio	0.68329118
95	MP0003283_abnormal_digestive_organ	0.66981258
96	MP0005195_abnormal_posterior_eye	0.64566891
97	MP0005645_abnormal_hypothalamus_physiol	0.64190667
98	MP0004130_abnormal_muscle_cell	0.64144531
99	MP0001963_abnormal_hearing_physiology	0.64060268
100	MP0002693_abnormal_pancreas_physiology	0.62945392

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	5.57003705
2	Pancreatic cysts (HP:0001737)	4.53970828
3	Congenital stationary night blindness (HP:0007642)	3.90405705
4	Pancreatic fibrosis (HP:0100732)	3.84682209
5	Abnormality of the renal cortex (HP:0011035)	3.78945981
6	True hermaphroditism (HP:0010459)	3.76430021
7	Amelogenesis imperfecta (HP:0000705)	3.72171032
8	Type II lissencephaly (HP:0007260)	3.63920309
9	Stomach cancer (HP:0012126)	3.53541069
10	Stomatitis (HP:0010280)	3.42184573
11	Parakeratosis (HP:0001036)	3.35278386
12	Nephronophthisis (HP:0000090)	3.19936131
13	Abnormality of the renal medulla (HP:0100957)	3.19639211
14	Abnormality of midbrain morphology (HP:0002418)	3.13986398
15	Molar tooth sign on MRI (HP:0002419)	3.13986398
16	Congenital, generalized hypertrichosis (HP:0004540)	3.01325060
17	Dialeptic seizures (HP:0011146)	2.96397966
18	Focal seizures (HP:0007359)	2.81060235
19	Elevated erythrocyte sedimentation rate (HP:0003565)	2.74423235
20	Pendular nystagmus (HP:0012043)	2.63007400
21	Cerebellar dysplasia (HP:0007033)	2.62611782
22	Abnormal drinking behavior (HP:0030082)	2.61410487
23	Polydipsia (HP:0001959)	2.61410487
24	Colon cancer (HP:0003003)	2.58687319
25	Abolished electroretinogram (ERG) (HP:0000550)	2.57340201
26	Inability to walk (HP:0002540)	2.56576949
27	Decreased central vision (HP:0007663)	2.54501810
28	Increased corneal curvature (HP:0100692)	2.53005776
29	Keratoconus (HP:0000563)	2.53005776
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.51132377
31	Attenuation of retinal blood vessels (HP:0007843)	2.50483226
32	Cystic liver disease (HP:0006706)	2.48785553
33	Large for gestational age (HP:0001520)	2.48085771
34	Renal cortical cysts (HP:0000803)	2.47272799
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.37610998
36	Hyperventilation (HP:0002883)	2.35014793
37	Congenital hepatic fibrosis (HP:0002612)	2.33781997
38	Gaze-evoked nystagmus (HP:0000640)	2.33486786
39	Chronic hepatic failure (HP:0100626)	2.31351389
40	Absent/shortened dynein arms (HP:0200106)	2.30910406
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30910406
42	Progressive inability to walk (HP:0002505)	2.30586854
43	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.29792746
44	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.28377049
45	Hematochezia (HP:0002573)	2.26736580
46	Medial flaring of the eyebrow (HP:0010747)	2.25247003
47	Polyuria (HP:0000103)	2.23862991
48	Tubulointerstitial fibrosis (HP:0005576)	2.18336855
49	Acute necrotizing encephalopathy (HP:0006965)	2.13388581
50	Hypothermia (HP:0002045)	2.12357195
51	Sclerocornea (HP:0000647)	2.11871214
52	Tubular atrophy (HP:0000092)	2.11858423
53	Progressive macrocephaly (HP:0004481)	2.04811584
54	Hemiparesis (HP:0001269)	2.02856301
55	Agitation (HP:0000713)	2.00931878
56	Type 2 muscle fiber atrophy (HP:0003554)	1.99333604
57	Bile duct proliferation (HP:0001408)	1.98405983
58	Abnormal biliary tract physiology (HP:0012439)	1.98405983
59	Mitochondrial inheritance (HP:0001427)	1.97996475
60	Abnormality of the pons (HP:0007361)	1.95126262
61	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.94958842
62	Calf muscle hypertrophy (HP:0008981)	1.93636485
63	Anencephaly (HP:0002323)	1.93367285
64	3-Methylglutaconic aciduria (HP:0003535)	1.92819424
65	Abnormal ciliary motility (HP:0012262)	1.92790325
66	Bilateral microphthalmos (HP:0007633)	1.90386283
67	Decreased circulating renin level (HP:0003351)	1.89996062
68	Optic neuritis (HP:0100653)	1.89203142
69	Retrobulbar optic neuritis (HP:0100654)	1.89203142
70	Constricted visual fields (HP:0001133)	1.84664597
71	Myositis (HP:0100614)	1.83132107
72	Abnormal respiratory motile cilium morphology (HP:0005938)	1.82106222
73	Abnormal respiratory epithelium morphology (HP:0012253)	1.82106222
74	Aplastic anemia (HP:0001915)	1.78517957
75	Tubulointerstitial abnormality (HP:0001969)	1.78126084
76	Increased CSF lactate (HP:0002490)	1.77141190
77	Male pseudohermaphroditism (HP:0000037)	1.76435192
78	Abnormality of macular pigmentation (HP:0008002)	1.75849854
79	Lissencephaly (HP:0001339)	1.74047961
80	Hypoplasia of the pons (HP:0012110)	1.73314517
81	Furrowed tongue (HP:0000221)	1.73188443
82	Prolonged QT interval (HP:0001657)	1.71405919
83	Fair hair (HP:0002286)	1.70463933
84	Optic nerve hypoplasia (HP:0000609)	1.70381268
85	Severe muscular hypotonia (HP:0006829)	1.70085160
86	Absence seizures (HP:0002121)	1.70038932
87	Abnormal urine output (HP:0012590)	1.69731955
88	Acute encephalopathy (HP:0006846)	1.68289628
89	Optic disc pallor (HP:0000543)	1.68204673
90	Gastrointestinal atresia (HP:0002589)	1.67613331
91	Ulnar claw (HP:0001178)	1.67062440
92	Muscle hypertrophy of the lower extremities (HP:0008968)	1.66101215
93	Type I transferrin isoform profile (HP:0003642)	1.65948079
94	Abnormal albumin level (HP:0012116)	1.65735867
95	Hypoalbuminemia (HP:0003073)	1.65735867
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.64331373
97	Bony spicule pigmentary retinopathy (HP:0007737)	1.63829397
98	Clumsiness (HP:0002312)	1.63414952
99	Hemiplegia (HP:0002301)	1.62758589
100	Orchitis (HP:0100796)	1.62224008

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.52919548
2	LATS1	4.37038973
3	STK38L	3.81538110
4	TAOK3	3.16415495
5	BMPR1B	2.94190044
6	ZAK	2.84467904
7	PINK1	2.73423807
8	ADRBK2	2.55416807
9	NLK	2.17448979
10	WNK3	2.13808919
11	PNCK	2.04751284
12	INSRR	1.96600089
13	MAP2K2	1.90074211
14	LATS2	1.84943748
15	TXK	1.82003461
16	MAP4K2	1.78587159
17	GRK1	1.64968738
18	DAPK2	1.54590248
19	ACVR1B	1.54577830
20	MAPK13	1.46043892
21	NUAK1	1.43784178
22	CAMKK2	1.41943758
23	MAPK15	1.38489156
24	STK3	1.33622222
25	WNK4	1.32396291
26	STK38	1.12866407
27	ADRBK1	1.09523352
28	TGFBR1	1.09466015
29	KIT	1.06943586
30	BRSK2	1.03001593
31	IKBKB	1.01177691
32	CASK	0.94645688
33	MAPKAPK5	0.94380584
34	TNIK	0.93682461
35	PIK3CG	0.90006643
36	MELK	0.89462070
37	OXSR1	0.89370588
38	IRAK4	0.85747251
39	TNK2	0.84343688
40	STK11	0.83910920
41	TIE1	0.82572122
42	GRK7	0.82191933
43	TEC	0.81229363
44	WEE1	0.79632203
45	GRK6	0.79089378
46	IKBKE	0.79026135
47	MKNK2	0.77998582
48	TLK1	0.76946041
49	SYK	0.75003707
50	FGFR2	0.74641016
51	TAF1	0.70489952
52	EIF2AK3	0.69629198
53	FES	0.68792428
54	GRK5	0.68486320
55	MUSK	0.67773409
56	PRKCG	0.66786427
57	MAPK7	0.64795597
58	ITK	0.64454456
59	PRKCE	0.63275249
60	PTK2B	0.62226375
61	VRK1	0.61159557
62	NEK9	0.60881223
63	PLK2	0.58523951
64	NME1	0.56191078
65	PRKAA2	0.55603568
66	MAP4K1	0.54534657
67	MAPKAPK3	0.54494652
68	CHUK	0.52857753
69	MAP3K4	0.50805410
70	DYRK2	0.50311627
71	RIPK4	0.50229671
72	CDK3	0.49087166
73	MATK	0.48665191
74	PRKD3	0.48055092
75	EPHB2	0.47979314
76	LYN	0.47297115
77	IRAK1	0.47208235
78	PASK	0.45526974
79	PAK3	0.44216839
80	TAOK1	0.43462500
81	PIM1	0.43421606
82	VRK2	0.42844353
83	CCNB1	0.42396330
84	CAMK1	0.40926758
85	MARK1	0.40239433
86	NTRK3	0.40021176
87	PRKCQ	0.38608916
88	PRKACA	0.37415968
89	NTRK2	0.37006218
90	STK16	0.36312198
91	PHKG1	0.34674449
92	PHKG2	0.34674449
93	FGR	0.34660908
94	MAP3K14	0.33034753
95	MAP3K7	0.31715438
96	CSF1R	0.31553143
97	JAK3	0.31207504
98	CDK8	0.30377560
99	LCK	0.30217937
100	BMPR2	0.29577325

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.76221656
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.87924073
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.76921618
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.67587459
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.53719508
6	Nicotine addiction_Homo sapiens_hsa05033	2.30413538
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.09735487
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.06266664
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.97872383
10	Oxidative phosphorylation_Homo sapiens_hsa00190	1.96413823
11	Caffeine metabolism_Homo sapiens_hsa00232	1.96121412
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83285818
13	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.82129663
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72131187
15	Morphine addiction_Homo sapiens_hsa05032	1.65028894
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.64311199
17	Taste transduction_Homo sapiens_hsa04742	1.64173434
18	Asthma_Homo sapiens_hsa05310	1.61750673
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.59056064
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.58184978
21	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.51411787
22	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.49889695
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.49019165
24	Butanoate metabolism_Homo sapiens_hsa00650	1.42556693
25	Graft-versus-host disease_Homo sapiens_hsa05332	1.34460217
26	Type I diabetes mellitus_Homo sapiens_hsa04940	1.34375917
27	Parkinsons disease_Homo sapiens_hsa05012	1.33848635
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.29859339
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.24973209
30	Olfactory transduction_Homo sapiens_hsa04740	1.24958649
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24602610
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.16944370
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15512795
34	Sphingolipid metabolism_Homo sapiens_hsa00600	1.13919083
35	Serotonergic synapse_Homo sapiens_hsa04726	1.12104072
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.11916506
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.11669421
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10400150
39	Histidine metabolism_Homo sapiens_hsa00340	1.09690971
40	Protein export_Homo sapiens_hsa03060	1.08352946
41	Allograft rejection_Homo sapiens_hsa05330	1.06664950
42	ABC transporters_Homo sapiens_hsa02010	1.01120809
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.01063225
44	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.00765401
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.99771158
46	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99382120
47	GABAergic synapse_Homo sapiens_hsa04727	0.98083930
48	Homologous recombination_Homo sapiens_hsa03440	0.97136340
49	Leishmaniasis_Homo sapiens_hsa05140	0.94808100
50	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.94248456
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94064626
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.91581781
53	Alzheimers disease_Homo sapiens_hsa05010	0.91267737
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91177595
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.88542914
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.87668030
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.87307119
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87098482
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87000066
60	African trypanosomiasis_Homo sapiens_hsa05143	0.83921483
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83189514
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82682699
63	Circadian entrainment_Homo sapiens_hsa04713	0.80210878
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.79268555
65	Insulin secretion_Homo sapiens_hsa04911	0.77748373
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77739251
67	Peroxisome_Homo sapiens_hsa04146	0.77605606
68	Tuberculosis_Homo sapiens_hsa05152	0.76768820
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76533679
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.74841084
71	Salivary secretion_Homo sapiens_hsa04970	0.70435416
72	Basal transcription factors_Homo sapiens_hsa03022	0.70323117
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.70098801
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67131626
75	Legionellosis_Homo sapiens_hsa05134	0.66536418
76	Regulation of autophagy_Homo sapiens_hsa04140	0.65916518
77	Huntingtons disease_Homo sapiens_hsa05016	0.64198350
78	Ribosome_Homo sapiens_hsa03010	0.64039385
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.61790696
80	Retinol metabolism_Homo sapiens_hsa00830	0.61331057
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59723228
82	Antigen processing and presentation_Homo sapiens_hsa04612	0.57822536
83	RNA polymerase_Homo sapiens_hsa03020	0.57362344
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.54709835
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53365237
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50523452
87	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50063482
88	Primary immunodeficiency_Homo sapiens_hsa05340	0.48522325
89	Osteoclast differentiation_Homo sapiens_hsa04380	0.44913140
90	One carbon pool by folate_Homo sapiens_hsa00670	0.44195709
91	Malaria_Homo sapiens_hsa05144	0.43357730
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.40857764
93	Mineral absorption_Homo sapiens_hsa04978	0.40423260
94	Pertussis_Homo sapiens_hsa05133	0.36095106
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.35371726
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32906426
97	RNA degradation_Homo sapiens_hsa03018	0.31074398
98	Propanoate metabolism_Homo sapiens_hsa00640	0.30799116
99	Cocaine addiction_Homo sapiens_hsa05030	0.28990187
100	Cholinergic synapse_Homo sapiens_hsa04725	0.27928130

SLC9A7P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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