SLC9A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine catabolic process (GO:0006554)7.22808609
2lysine metabolic process (GO:0006553)7.22808609
3tryptophan catabolic process (GO:0006569)6.24076929
4indole-containing compound catabolic process (GO:0042436)6.24076929
5indolalkylamine catabolic process (GO:0046218)6.24076929
6kynurenine metabolic process (GO:0070189)6.02471249
7aromatic amino acid family catabolic process (GO:0009074)5.95230520
8cysteine metabolic process (GO:0006534)5.93130852
9drug transmembrane transport (GO:0006855)5.89772487
10tryptophan metabolic process (GO:0006568)5.78601823
11urate metabolic process (GO:0046415)5.74952438
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.62792114
13L-phenylalanine catabolic process (GO:0006559)5.62792114
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.53469448
15negative regulation of cell killing (GO:0031342)5.53469448
16L-phenylalanine metabolic process (GO:0006558)5.49844020
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.49844020
182-oxoglutarate metabolic process (GO:0006103)5.24354089
19drug transport (GO:0015893)5.22373023
20valine metabolic process (GO:0006573)5.17329259
21homocysteine metabolic process (GO:0050667)5.05878564
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94077899
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.93142324
24positive regulation by symbiont of host defense response (GO:0052509)4.91117554
25modulation by symbiont of host defense response (GO:0052031)4.91117554
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.91117554
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.91117554
28positive regulation by organism of defense response of other organism involved in symbiotic interact4.91117554
29modulation by symbiont of host immune response (GO:0052553)4.91117554
30organic cation transport (GO:0015695)4.90726264
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.87718957
32glyoxylate metabolic process (GO:0046487)4.83286135
33amino-acid betaine metabolic process (GO:0006577)4.69477797
34aspartate family amino acid catabolic process (GO:0009068)4.64426040
35antigen processing and presentation of endogenous antigen (GO:0019883)4.58699436
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.57444930
37response to peptidoglycan (GO:0032494)4.54419017
38serine family amino acid catabolic process (GO:0009071)4.48862647
39macrophage activation involved in immune response (GO:0002281)4.33349890
40detection of other organism (GO:0098543)4.32723422
41sulfur amino acid catabolic process (GO:0000098)4.29614285
42cellular modified amino acid catabolic process (GO:0042219)4.29352902
43indolalkylamine metabolic process (GO:0006586)4.23413465
44phosphate ion transport (GO:0006817)4.22105806
45quaternary ammonium group transport (GO:0015697)4.21351500
46glutamate metabolic process (GO:0006536)4.21215325
47aromatic amino acid family metabolic process (GO:0009072)4.14916052
48detection of bacterium (GO:0016045)4.11907093
49tricarboxylic acid metabolic process (GO:0072350)4.10882431
50short-chain fatty acid metabolic process (GO:0046459)4.07709324
51regulation of gamma-delta T cell activation (GO:0046643)4.05468080
52cellular biogenic amine catabolic process (GO:0042402)4.03418048
53amine catabolic process (GO:0009310)4.03418048
54carnitine transport (GO:0015879)4.02989404
55amino-acid betaine transport (GO:0015838)4.02989404
56leukocyte aggregation (GO:0070486)4.01113890
57carnitine metabolic process (GO:0009437)3.99338699
58negative regulation of interleukin-12 production (GO:0032695)3.94838944
59branched-chain amino acid metabolic process (GO:0009081)3.94166662
60detection of molecule of bacterial origin (GO:0032490)3.93751219
61neutrophil activation involved in immune response (GO:0002283)3.93174131
62phosphate ion transmembrane transport (GO:0035435)3.92996175
63dicarboxylic acid biosynthetic process (GO:0043650)3.87663521
64regulation of B cell receptor signaling pathway (GO:0050855)3.86538105
65acetyl-CoA metabolic process (GO:0006084)3.86332149
66alpha-amino acid catabolic process (GO:1901606)3.84976700
67fatty acid beta-oxidation (GO:0006635)3.84314369
68regulation of cholesterol homeostasis (GO:2000188)3.84080497
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83319825
70response to muramyl dipeptide (GO:0032495)3.83088888
71detection of external biotic stimulus (GO:0098581)3.80511541
72alpha-linolenic acid metabolic process (GO:0036109)3.79005126
73germinal center formation (GO:0002467)3.76860575
74regulation of interferon-beta biosynthetic process (GO:0045357)3.76655099
75response to mercury ion (GO:0046689)3.75276313
76fatty acid oxidation (GO:0019395)3.75137559
77lipid oxidation (GO:0034440)3.69695736
78urea cycle (GO:0000050)3.69360688
79urea metabolic process (GO:0019627)3.69360688
80cellular amino acid catabolic process (GO:0009063)3.69112290
81bile acid biosynthetic process (GO:0006699)3.68354232
82cellular extravasation (GO:0045123)3.67679140
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.64558936
84serine family amino acid metabolic process (GO:0009069)3.63312724
85negative regulation of lymphocyte mediated immunity (GO:0002707)3.63064009
86benzene-containing compound metabolic process (GO:0042537)3.60632682
87response to interleukin-15 (GO:0070672)3.58135759
88negative regulation of cholesterol transport (GO:0032375)3.58101860
89negative regulation of sterol transport (GO:0032372)3.58101860
90negative regulation of erythrocyte differentiation (GO:0045647)3.57828473
91drug catabolic process (GO:0042737)3.57630507
92tolerance induction (GO:0002507)3.57441695
93fructose metabolic process (GO:0006000)3.56906337
94phospholipid homeostasis (GO:0055091)3.56114792
95cellular ketone body metabolic process (GO:0046950)3.55023912
96regulation of gamma-delta T cell differentiation (GO:0045586)3.54298504
97toxin transport (GO:1901998)3.50548961
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46695210
99response to host immune response (GO:0052572)3.46695210
100biotin metabolic process (GO:0006768)3.46045916
101response to type I interferon (GO:0034340)3.45533617
102type I interferon signaling pathway (GO:0060337)3.45095385
103cellular response to type I interferon (GO:0071357)3.45095385
104response to host defenses (GO:0052200)3.40020115
105response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40020115
106response to host (GO:0075136)3.40020115
107nitrogen cycle metabolic process (GO:0071941)3.38465829
108detection of biotic stimulus (GO:0009595)3.34596893
109bile acid metabolic process (GO:0008206)3.32409955
110neutrophil activation (GO:0042119)3.30075666
111branched-chain amino acid catabolic process (GO:0009083)3.28691342
112organic acid catabolic process (GO:0016054)3.28660621
113carboxylic acid catabolic process (GO:0046395)3.28660621
114oxaloacetate metabolic process (GO:0006107)3.28600265
115negative regulation of leukocyte mediated immunity (GO:0002704)3.28258623
116fatty acid catabolic process (GO:0009062)3.26383539
117lipopolysaccharide-mediated signaling pathway (GO:0031663)3.23011778
118NIK/NF-kappaB signaling (GO:0038061)3.21501087
119monocarboxylic acid catabolic process (GO:0072329)3.17761527
120negative regulation of T cell mediated immunity (GO:0002710)3.17253381
121carnitine transmembrane transport (GO:1902603)3.16604936
122negative thymic T cell selection (GO:0045060)3.16376202
123macrophage activation (GO:0042116)3.16010141
124triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.13726988
125regulation of T-helper 2 cell differentiation (GO:0045628)3.12714213
126peptidyl-glutamic acid carboxylation (GO:0017187)3.11977665
127protein carboxylation (GO:0018214)3.11977665
128granulocyte activation (GO:0036230)3.11499092
129excretion (GO:0007588)3.11125392
130response to phenylpropanoid (GO:0080184)3.08927975
131regulation of tolerance induction (GO:0002643)3.08922841
132indole-containing compound metabolic process (GO:0042430)3.08504951
133B cell receptor signaling pathway (GO:0050853)3.07816518
134cellular response to interleukin-15 (GO:0071350)3.06338780
135carnitine shuttle (GO:0006853)3.04939296
136immunoglobulin mediated immune response (GO:0016064)3.04529545
137tyrosine metabolic process (GO:0006570)3.01758327
138regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01381867
139negative T cell selection (GO:0043383)3.00571149
140respiratory burst (GO:0045730)3.00541628
141fatty acid transmembrane transport (GO:1902001)2.99570110
142myeloid cell activation involved in immune response (GO:0002275)2.99343333
143ketone body metabolic process (GO:1902224)2.98367362
144dicarboxylic acid metabolic process (GO:0043648)2.97474563
145production of molecular mediator involved in inflammatory response (GO:0002532)2.97116241
146regulation of mast cell degranulation (GO:0043304)2.96932767
147serine family amino acid biosynthetic process (GO:0009070)2.96768819
148regulation of T cell tolerance induction (GO:0002664)2.96520247
149negative regulation of toll-like receptor signaling pathway (GO:0034122)2.96285259
150renal absorption (GO:0070293)2.95242950
151exogenous drug catabolic process (GO:0042738)2.95077001
152defense response to protozoan (GO:0042832)2.94061881
153negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93714793
154neutrophil mediated immunity (GO:0002446)2.93577514
155positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93534109
156proline metabolic process (GO:0006560)2.92480945
157aminoglycoside antibiotic metabolic process (GO:0030647)2.91985795
158microglial cell activation (GO:0001774)2.91875604
159macroautophagy (GO:0016236)2.91871610
160negative regulation of innate immune response (GO:0045824)2.91508601
161positive thymic T cell selection (GO:0045059)2.90545807
162regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90239446
163regulation of leukocyte degranulation (GO:0043300)2.87811188
164positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87509266
165positive regulation of tolerance induction (GO:0002645)2.87420822
166regulation of triglyceride catabolic process (GO:0010896)2.86012312
167negative regulation of interleukin-6 production (GO:0032715)2.85711785
168coenzyme catabolic process (GO:0009109)2.83395312
169regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83223687
170complement activation, alternative pathway (GO:0006957)2.82690296
171regulation of necroptotic process (GO:0060544)2.82152885
172high-density lipoprotein particle remodeling (GO:0034375)2.81622295
173negative regulation of type 2 immune response (GO:0002829)2.80869395
174positive regulation of gamma-delta T cell activation (GO:0046645)2.80170782
175negative regulation of cytokine production involved in immune response (GO:0002719)2.79805184
176positive regulation of cellular amide metabolic process (GO:0034250)2.79356058
177basic amino acid transport (GO:0015802)2.78550370
178interferon-gamma-mediated signaling pathway (GO:0060333)2.78474533
179thymic T cell selection (GO:0045061)2.77023367
180response to growth hormone (GO:0060416)2.75045795
181leukocyte migration involved in inflammatory response (GO:0002523)2.74835364
182T cell selection (GO:0045058)2.73723741
183triglyceride homeostasis (GO:0070328)2.72600113
184acylglycerol homeostasis (GO:0055090)2.72600113
185nonribosomal peptide biosynthetic process (GO:0019184)2.72084917
186positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71383663
187T cell migration (GO:0072678)2.70930367
188negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.69918381
189positive regulation of interferon-alpha production (GO:0032727)2.69424001
190response to protozoan (GO:0001562)2.68520217
191negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68317743
192negative regulation of T-helper cell differentiation (GO:0045623)2.68317743
193antigen processing and presentation via MHC class Ib (GO:0002475)2.65844528
194regulation of mast cell activation involved in immune response (GO:0033006)2.65020510
195regulation of interleukin-12 biosynthetic process (GO:0045075)2.64693792
196myeloid dendritic cell differentiation (GO:0043011)2.64137088
197regulation of toll-like receptor signaling pathway (GO:0034121)2.63161796
198positive regulation of type 2 immune response (GO:0002830)2.61846026
199dendritic cell chemotaxis (GO:0002407)2.59178192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.96896296
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.48728758
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.97114059
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.44255697
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.47422110
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.29209926
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.20019047
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.14422457
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07806907
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.03947536
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.64593413
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.51905082
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33924714
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.24304279
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17528883
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12587025
17MYC_22102868_ChIP-Seq_BL_Human2.01270402
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00676606
19SPI1_23547873_ChIP-Seq_NB4_Human1.90601963
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84983702
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83224942
22GATA1_22025678_ChIP-Seq_K562_Human1.81760515
23* FOXA2_19822575_ChIP-Seq_HepG2_Human1.70738158
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.62492757
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62349122
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61314559
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60298272
28TCF7_22412390_ChIP-Seq_EML_Mouse1.59215476
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51454997
30LXR_22292898_ChIP-Seq_THP-1_Human1.48729225
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.47917733
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46197293
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.46027607
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45588502
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.43890244
36SCL_19346495_ChIP-Seq_HPC-7_Human1.42275829
37VDR_24787735_ChIP-Seq_THP-1_Human1.41952362
38MAF_26560356_Chip-Seq_TH1_Human1.40584537
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40526623
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40320773
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40150045
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.40082628
43VDR_21846776_ChIP-Seq_THP-1_Human1.38511239
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37505296
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37469063
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37144350
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.34988481
48* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34175252
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33853264
50* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32372902
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32149728
52MYB_26560356_Chip-Seq_TH1_Human1.31082239
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30260877
54* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30189366
55* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28836999
56* RUNX_20019798_ChIP-Seq_JUKART_Human1.27898885
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25838400
58UTX_26944678_Chip-Seq_JUKART_Human1.25182665
59* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24433627
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23812251
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23226581
62KDM2B_26808549_Chip-Seq_K562_Human1.22415588
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21502700
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.21368311
65GATA1_19941826_ChIP-Seq_K562_Human1.19179282
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18179890
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17858702
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.16769692
69GATA6_25053715_ChIP-Seq_YYC3_Human1.13094428
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12990037
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12777231
72KDM2B_26808549_Chip-Seq_DND41_Human1.11335724
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10451923
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10418167
75TBX20_22328084_ChIP-Seq_HEART_Mouse1.10405964
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.10405964
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10368593
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10323330
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10174249
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08511758
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08229659
82* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06921658
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06373510
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06359988
85SPI1_23127762_ChIP-Seq_K562_Human1.05915720
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04881839
87* GATA2_19941826_ChIP-Seq_K562_Human1.03457327
88GATA4_25053715_ChIP-Seq_YYC3_Human1.02044211
89RACK7_27058665_Chip-Seq_MCF-7_Human1.01701462
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01237764
91RUNX1_22412390_ChIP-Seq_EML_Mouse1.01097166
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00848190
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98570265
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97680889
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97549077
96BCL6_27268052_Chip-Seq_Bcells_Human0.97028634
97MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96891532
98* MYB_26560356_Chip-Seq_TH2_Human0.96237865
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95740331
100RUNX1_27514584_Chip-Seq_MCF-7_Human0.94415900
101SA1_27219007_Chip-Seq_ERYTHROID_Human0.94064049
102* VDR_24763502_ChIP-Seq_THP-1_Human0.93564766
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93168630
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93134934
105* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93015348
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91683377
107* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91197234
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88629277
109FOXO3_23340844_ChIP-Seq_DLD1_Human0.87359059
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.87344349
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86618419
112CLOCK_20551151_ChIP-Seq_293T_Human0.86178647
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85720313
114* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.84409679
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84380775
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84113629
117PU_27001747_Chip-Seq_BMDM_Mouse0.83554559
118* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82720322
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82639177
120GATA3_27048872_Chip-Seq_THYMUS_Human0.82527038
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.81755683
122P68_20966046_ChIP-Seq_HELA_Human0.81504526
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81471264
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80210434
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.80043433
126* NCOR1_26117541_ChIP-Seq_K562_Human0.79994687
127SMC4_20622854_ChIP-Seq_HELA_Human0.79796556
128MAF_26560356_Chip-Seq_TH2_Human0.79207937
129BCOR_27268052_Chip-Seq_Bcells_Human0.76934902
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76543522
131GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76533802
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76245711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.04221870
2MP0002139_abnormal_hepatobiliary_system5.75626848
3MP0005365_abnormal_bile_salt4.39419922
4MP0003303_peritoneal_inflammation3.89889315
5MP0005085_abnormal_gallbladder_physiolo3.72410596
6MP0003195_calcinosis3.37275549
7MP0005332_abnormal_amino_acid3.35036898
8MP0003252_abnormal_bile_duct3.32835946
9MP0008875_abnormal_xenobiotic_pharmacok3.26966547
10MP0004043_abnormal_pH_regulation3.02941605
11MP0002138_abnormal_hepatobiliary_system2.89470293
12MP0004019_abnormal_vitamin_homeostasis2.72917452
13MP0009785_altered_susceptibility_to2.59158473
14MP0009643_abnormal_urine_homeostasis2.51829384
15MP0005671_abnormal_response_to2.42013482
16MP0003191_abnormal_cellular_cholesterol2.40539783
17MP0008961_abnormal_basal_metabolism2.32740056
18MP0010329_abnormal_lipoprotein_level2.26875485
19MP0003300_gastrointestinal_ulcer2.22103235
20MP0002420_abnormal_adaptive_immunity2.21542676
21MP0001819_abnormal_immune_cell2.19763812
22MP0008260_abnormal_autophagy2.14907756
23MP0002148_abnormal_hypersensitivity_rea2.12947199
24MP0001533_abnormal_skeleton_physiology2.07717637
25MP0001666_abnormal_nutrient_absorption2.04697990
26MP0002405_respiratory_system_inflammati2.01156036
27MP0003806_abnormal_nucleotide_metabolis1.90544871
28MP0005670_abnormal_white_adipose1.87339807
29MP0001756_abnormal_urination1.85159050
30MP0005058_abnormal_lysosome_morphology1.83102270
31MP0000609_abnormal_liver_physiology1.80198827
32MP0009840_abnormal_foam_cell1.76134766
33MP0001765_abnormal_ion_homeostasis1.74212942
34MP0004510_myositis1.72718136
35MP0002398_abnormal_bone_marrow1.70813089
36MP0002136_abnormal_kidney_physiology1.68733342
37MP0000716_abnormal_immune_system1.68481884
38MP0002118_abnormal_lipid_homeostasis1.60850284
39MP0005319_abnormal_enzyme/_coenzyme1.59672346
40MP0003172_abnormal_lysosome_physiology1.59418073
41MP0005636_abnormal_mineral_homeostasis1.55890315
42MP0005083_abnormal_biliary_tract1.54163690
43MP0009333_abnormal_splenocyte_physiolog1.52850158
44MP0003878_abnormal_ear_physiology1.52609359
45MP0005377_hearing/vestibular/ear_phenot1.52609359
46MP0002928_abnormal_bile_duct1.50893608
47MP0000858_altered_metastatic_potential1.50234937
48MP0000465_gastrointestinal_hemorrhage1.49036110
49MP0003828_pulmonary_edema1.48820442
50MP0005584_abnormal_enzyme/coenzyme_acti1.46259748
51MP0002132_abnormal_respiratory_system1.45267256
52MP0000569_abnormal_digit_pigmentation1.45143658
53MP0003868_abnormal_feces_composition1.43291499
54MP0002722_abnormal_immune_system1.43004975
55MP0002998_abnormal_bone_remodeling1.40911562
56MP0001764_abnormal_homeostasis1.38965482
57MP0002429_abnormal_blood_cell1.32956741
58MP0004381_abnormal_hair_follicle1.32889345
59MP0000703_abnormal_thymus_morphology1.31979296
60MP0005310_abnormal_salivary_gland1.31950806
61MP0003075_altered_response_to1.28478296
62MP0004264_abnormal_extraembryonic_tissu1.26748944
63MP0001851_eye_inflammation1.26521151
64MP0005076_abnormal_cell_differentiation1.23950498
65MP0001545_abnormal_hematopoietic_system1.22418370
66MP0005397_hematopoietic_system_phenotyp1.22418370
67MP0004130_abnormal_muscle_cell1.14102763
68MP0003436_decreased_susceptibility_to1.13933958
69MP0004883_abnormal_blood_vessel1.09828259
70MP0001790_abnormal_immune_system1.08046580
71MP0005387_immune_system_phenotype1.08046580
72MP0001853_heart_inflammation1.08040203
73MP0009764_decreased_sensitivity_to1.07577678
74MP0008469_abnormal_protein_level1.05737474
75MP0003453_abnormal_keratinocyte_physiol1.05194115
76MP0003091_abnormal_cell_migration1.04769586
77MP0005166_decreased_susceptibility_to1.04095672
78MP0003690_abnormal_glial_cell1.03069919
79MP0005164_abnormal_response_to1.03034995
80MP0008004_abnormal_stomach_pH1.02333248
81MP0000598_abnormal_liver_morphology1.01892590
82MP0005220_abnormal_exocrine_pancreas0.97098408
83MP0002078_abnormal_glucose_homeostasis0.96678364
84MP0002933_joint_inflammation0.96343331
85MP0002168_other_aberrant_phenotype0.96027922
86MP0003448_altered_tumor_morphology0.95019628
87MP0000685_abnormal_immune_system0.94636464
88MP0002277_abnormal_respiratory_mucosa0.94373250
89MP0003283_abnormal_digestive_organ0.94349752
90MP0005666_abnormal_adipose_tissue0.93627318
91MP0005464_abnormal_platelet_physiology0.93006995
92MP0001835_abnormal_antigen_presentation0.92748604
93MP0009642_abnormal_blood_homeostasis0.92417811
94MP0003183_abnormal_peptide_metabolism0.91269454
95MP0003646_muscle_fatigue0.90382100
96MP0003724_increased_susceptibility_to0.89307698
97MP0002332_abnormal_exercise_endurance0.88928767
98MP0005535_abnormal_body_temperature0.87527147
99MP0004808_abnormal_hematopoietic_stem0.87507727
100MP0001845_abnormal_inflammatory_respons0.87289925
101MP0005390_skeleton_phenotype0.87231173
102MP0000371_diluted_coat_color0.87199495
103MP0001800_abnormal_humoral_immune0.85703890
104MP0002166_altered_tumor_susceptibility0.84055479
105MP0001663_abnormal_digestive_system0.83584760
106MP0002396_abnormal_hematopoietic_system0.82922497
107MP0002876_abnormal_thyroid_physiology0.80735778
108MP0003045_fibrosis0.79005527
109MP0000538_abnormal_urinary_bladder0.79001996
110MP0003656_abnormal_erythrocyte_physiolo0.78279408
111MP0002135_abnormal_kidney_morphology0.76155672
112MP0000249_abnormal_blood_vessel0.76134169
113MP0003566_abnormal_cell_adhesion0.75088839
114MP0003763_abnormal_thymus_physiology0.75025389
115MP0009763_increased_sensitivity_to0.75005234
116MP0006082_CNS_inflammation0.74715193
117MP0006036_abnormal_mitochondrial_physio0.73804326
118MP0009278_abnormal_bone_marrow0.73804241
119MP0010155_abnormal_intestine_physiology0.73164358
120MP0003705_abnormal_hypodermis_morpholog0.73103648
121MP0000343_altered_response_to0.72800715
122MP0003795_abnormal_bone_structure0.72082326
123MP0001661_extended_life_span0.71344211
124MP0002009_preneoplasia0.70575747
125MP0002254_reproductive_system_inflammat0.69679966
126MP0009765_abnormal_xenobiotic_induced0.69558916
127MP0003186_abnormal_redox_activity0.69460568
128MP0005334_abnormal_fat_pad0.68787248
129MP0003329_amyloid_beta_deposits0.68252582
130MP0008874_decreased_physiological_sensi0.66953627
131MP0002723_abnormal_immune_serum0.65883695
132MP0000689_abnormal_spleen_morphology0.65805614
133MP0003866_abnormal_defecation0.65197461
134MP0004947_skin_inflammation0.64149162
135MP0002971_abnormal_brown_adipose0.63975833
136MP0005025_abnormal_response_to0.63926651
137MP0000490_abnormal_crypts_of0.63373355
138MP0001849_ear_inflammation0.63302774
139MP0002419_abnormal_innate_immunity0.62711584
140MP0002269_muscular_atrophy0.62670915
141MP0005375_adipose_tissue_phenotype0.62196953
142MP0005647_abnormal_sex_gland0.62150265
143MP0002006_tumorigenesis0.62099856
144MP0001873_stomach_inflammation0.62053999
145MP0000604_amyloidosis0.61564430
146MP0005023_abnormal_wound_healing0.61092288
147MP0005000_abnormal_immune_tolerance0.60838643
148MP0002877_abnormal_melanocyte_morpholog0.60056830
149MP0001944_abnormal_pancreas_morphology0.59887742
150MP0003221_abnormal_cardiomyocyte_apopto0.59462652
151MP0009780_abnormal_chondrocyte_physiolo0.58621219
152MP0002452_abnormal_antigen_presenting0.57424756
153MP0000230_abnormal_systemic_arterial0.57049968
154MP0005451_abnormal_body_composition0.56718830
155MP0001958_emphysema0.56507376
156MP0003953_abnormal_hormone_level0.56155541
157MP0003959_abnormal_lean_body0.54386418

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.03848928
2Gout (HP:0001997)5.41297710
3Hyperglycinuria (HP:0003108)5.03664939
4Myositis (HP:0100614)4.88945114
5Recurrent abscess formation (HP:0002722)4.73070611
6Orchitis (HP:0100796)4.70827973
7Recurrent bacterial skin infections (HP:0005406)4.69503632
8Abnormality of macrophages (HP:0004311)4.58586614
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.57321518
10Increased circulating renin level (HP:0000848)4.46033986
11Ketoacidosis (HP:0001993)4.43235535
12Retrobulbar optic neuritis (HP:0100654)4.40741966
13Optic neuritis (HP:0100653)4.40741966
14Hyperactive renin-angiotensin system (HP:0000841)4.36876974
15Ketosis (HP:0001946)4.29867408
16Metabolic alkalosis (HP:0200114)4.27626429
17Increased purine levels (HP:0004368)4.24896937
18Hyperuricemia (HP:0002149)4.24896937
19Abnormality of purine metabolism (HP:0004352)4.23094043
20Hypomagnesemia (HP:0002917)4.19850093
21Recurrent gram-negative bacterial infections (HP:0005420)4.16608155
22Abnormality of serine family amino acid metabolism (HP:0010894)4.09709630
23Abnormality of glycine metabolism (HP:0010895)4.09709630
24Abnormal urine output (HP:0012590)4.09041958
25Polyuria (HP:0000103)4.07207323
26Hypokalemic alkalosis (HP:0001949)4.06151079
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.93669331
28Stomatitis (HP:0010280)3.82218907
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.81434432
30Abnormality of chloride homeostasis (HP:0011422)3.77355277
31Proximal tubulopathy (HP:0000114)3.65305646
32Abnormality of renal excretion (HP:0011036)3.59311671
33Elevated erythrocyte sedimentation rate (HP:0003565)3.58911497
34Mediastinal lymphadenopathy (HP:0100721)3.57516447
35Recurrent fungal infections (HP:0002841)3.54738483
36Abnormality of nucleobase metabolism (HP:0010932)3.53121283
37Abnormal drinking behavior (HP:0030082)3.49392030
38Polydipsia (HP:0001959)3.49392030
39Tetany (HP:0001281)3.46819639
40Abnormality of aspartate family amino acid metabolism (HP:0010899)3.46724543
41Abnormality of magnesium homeostasis (HP:0004921)3.44757435
42Gastrointestinal infarctions (HP:0005244)3.44540182
43Abnormality of fatty-acid metabolism (HP:0004359)3.38095853
44Intrahepatic cholestasis (HP:0001406)3.33967405
45Alkalosis (HP:0001948)3.32071436
46Gingivitis (HP:0000230)3.23824993
47Increased IgE level (HP:0003212)3.22346680
48Hyperammonemia (HP:0001987)3.20070555
49Meningitis (HP:0001287)3.19846312
50Hyperglycinemia (HP:0002154)3.19785563
51Xanthomatosis (HP:0000991)3.18613700
52Abnormal delayed hypersensitivity skin test (HP:0002963)3.16481793
53Chronic obstructive pulmonary disease (HP:0006510)3.15659514
54Obstructive lung disease (HP:0006536)3.15659514
55Keratoconjunctivitis sicca (HP:0001097)3.14442019
56Recurrent skin infections (HP:0001581)3.14316504
57Abnormality of monocarboxylic acid metabolism (HP:0010996)3.12976904
58Hypoglycemic coma (HP:0001325)3.12702477
59Vasculitis (HP:0002633)3.06211000
60Spontaneous hematomas (HP:0007420)2.96445300
61Recurrent cutaneous fungal infections (HP:0011370)2.88619592
62Chronic mucocutaneous candidiasis (HP:0002728)2.88619592
63Abnormality of renin-angiotensin system (HP:0000847)2.86855288
64Joint hemorrhage (HP:0005261)2.83202174
65Cellulitis (HP:0100658)2.81810842
66Keratoconjunctivitis (HP:0001096)2.81223089
67Deep venous thrombosis (HP:0002625)2.80571447
68Encephalitis (HP:0002383)2.80457646
69Generalized aminoaciduria (HP:0002909)2.75402585
70Pulmonary infiltrates (HP:0002113)2.70663061
71T lymphocytopenia (HP:0005403)2.70608624
72Hyperaldosteronism (HP:0000859)2.69722938
73Recurrent viral infections (HP:0004429)2.66272942
74Urticaria (HP:0001025)2.64465240
75Abnormality of the fingertips (HP:0001211)2.64307506
76Renal salt wasting (HP:0000127)2.63263630
77Metabolic acidosis (HP:0001942)2.58569366
78Pustule (HP:0200039)2.58188094
79Arterial thrombosis (HP:0004420)2.57797787
80Prolonged bleeding time (HP:0003010)2.57147210
81Renal tubular acidosis (HP:0001947)2.55354419
82Delayed CNS myelination (HP:0002188)2.52013544
83Chest pain (HP:0100749)2.51731610
84Abnormality of T cell number (HP:0011839)2.51707296
85Hypercalciuria (HP:0002150)2.51328067
86Myocardial infarction (HP:0001658)2.50850183
87Gingival bleeding (HP:0000225)2.50405197
88Hemoptysis (HP:0002105)2.49651930
89Increased IgM level (HP:0003496)2.49304207
90Gastrointestinal inflammation (HP:0004386)2.48540691
91Inflammation of the large intestine (HP:0002037)2.46122775
92Nasal polyposis (HP:0100582)2.41598228
93Amyloidosis (HP:0011034)2.40195084
94Abnormality of proline metabolism (HP:0010907)2.39547442
95Hydroxyprolinuria (HP:0003080)2.39547442
96Increased cerebral lipofuscin (HP:0011813)2.37054564
97Autoimmune thrombocytopenia (HP:0001973)2.36669444
98Epistaxis (HP:0000421)2.33512172
99Nephrocalcinosis (HP:0000121)2.32438504
100Loss of speech (HP:0002371)2.30350404
101Peritonitis (HP:0002586)2.28885230
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28748586
103Dicarboxylic aciduria (HP:0003215)2.28748586
104Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28557925
105Prolonged partial thromboplastin time (HP:0003645)2.28244020
106Abnormality of glycolipid metabolism (HP:0010969)2.27873961
107Abnormality of liposaccharide metabolism (HP:0010968)2.27873961
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.27873961
109Nephrolithiasis (HP:0000787)2.27064348
110Enlarged kidneys (HP:0000105)2.26907994
111Hyperlipoproteinemia (HP:0010980)2.26556107
112Abnormality of the common coagulation pathway (HP:0010990)2.25405762
113Pulmonary embolism (HP:0002204)2.25248217
114Hypokalemia (HP:0002900)2.24529024
115Leukocytosis (HP:0001974)2.23209254
116Vascular calcification (HP:0004934)2.22636520
117Complement deficiency (HP:0004431)2.22527175
118Interstitial pulmonary disease (HP:0006530)2.20270409
119Slow saccadic eye movements (HP:0000514)2.19466968
120Granulocytopenia (HP:0001913)2.19040740
121Hypochromic anemia (HP:0001931)2.18772459
122Recurrent bronchitis (HP:0002837)2.17972750
123Obstructive sleep apnea (HP:0002870)2.17837205
124Anorexia (HP:0002039)2.17513823
125Abnormality of the nasal mucosa (HP:0000433)2.17279563
126Episodic fever (HP:0001954)2.13366868
127Abnormality of T cells (HP:0002843)2.13195362
128Abnormality of pyrimidine metabolism (HP:0004353)2.13175763
129Hemorrhage of the eye (HP:0011885)2.12630033
130Osteomyelitis (HP:0002754)2.10702247
131Hypergammaglobulinemia (HP:0010702)2.09958284
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09940788
133Gastrointestinal stroma tumor (HP:0100723)2.09736671
134Gangrene (HP:0100758)2.09588519
135Increased serum ferritin (HP:0003281)2.09073629
136Hypoglycemic seizures (HP:0002173)2.08489744
137Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07272596
138Abnormality of polysaccharide metabolism (HP:0011012)2.07272596
139Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07272596
140Abnormality of potassium homeostasis (HP:0011042)2.05196744
141Hypochromic microcytic anemia (HP:0004840)2.05103844
142Late onset (HP:0003584)2.04455830
143Purpura (HP:0000979)2.02909969
144Fat malabsorption (HP:0002630)2.02575399
145Hypophosphatemia (HP:0002148)2.02020663
146Hypoalphalipoproteinemia (HP:0003233)2.01762385
147Urinary glycosaminoglycan excretion (HP:0003541)2.00567878
148Mucopolysacchariduria (HP:0008155)2.00567878
149Mitral stenosis (HP:0001718)1.99691465
150Vomiting (HP:0002013)1.99543278
151Panhypogammaglobulinemia (HP:0003139)1.99190780
152Hyperinsulinemic hypoglycemia (HP:0000825)1.98611847
153Increased neuronal autofluorescent lipopigment (HP:0002074)1.97569221
154Abnormality of the intrinsic pathway (HP:0010989)1.96820063
155Abnormality of the endocardium (HP:0004306)1.96148326
156Fatigue (HP:0012378)1.94877395
157Epidermoid cyst (HP:0200040)1.94463889
158Recurrent sinusitis (HP:0011108)1.93610666
159Acne (HP:0001061)1.92860269
160Abnormal enzyme/coenzyme activity (HP:0012379)1.91656145
161Systemic lupus erythematosus (HP:0002725)1.91545054
162Segmental peripheral demyelination/remyelination (HP:0003481)1.90991135
163Abnormality of the peritoneum (HP:0002585)1.89522273
164Restrictive lung disease (HP:0002091)1.89427221
165Lymphopenia (HP:0001888)1.89315202
166Vacuolated lymphocytes (HP:0001922)1.89302349
167Confusion (HP:0001289)1.88809507
168Abnormality of methionine metabolism (HP:0010901)1.88107693
169Abnormality of the pleura (HP:0002103)1.87662031
170Cardiovascular calcification (HP:0011915)1.86985370
171Joint swelling (HP:0001386)1.85982119
172Hepatocellular carcinoma (HP:0001402)1.85317706
173Hyperbilirubinemia (HP:0002904)1.84885473
174Sepsis (HP:0100806)1.84289688
175Premature loss of primary teeth (HP:0006323)1.84202098
176Abnormality of serum amino acid levels (HP:0003112)1.83457254
177Autoimmune hemolytic anemia (HP:0001890)1.82204775
178Glomerulopathy (HP:0100820)1.82098128
179Sensorimotor neuropathy (HP:0007141)1.81817368
180Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80435967
181Facial shape deformation (HP:0011334)1.80191655
182Potter facies (HP:0002009)1.80191655
183Chronic otitis media (HP:0000389)1.80019631
184Glycosuria (HP:0003076)1.79652137
185Abnormality of urine glucose concentration (HP:0011016)1.79652137
186Malnutrition (HP:0004395)1.79449679
187Abnormality of T cell physiology (HP:0011840)1.79322512
188Abnormality of alkaline phosphatase activity (HP:0004379)1.78652414
189Dysostosis multiplex (HP:0000943)1.78091302
190Colitis (HP:0002583)1.77829289
191Esophageal varix (HP:0002040)1.77371889
192Neonatal onset (HP:0003623)1.77332773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.75190601
2ERN14.01217094
3RIPK43.51910371
4MAP4K13.08865030
5PRPF4B2.92982824
6BCKDK2.80572670
7WNK42.49330361
8FGFR42.37922874
9SIK12.26242125
10OXSR12.18276161
11INSRR2.09793118
12TAOK32.04340282
13MAP3K141.93119454
14TRIB31.87906159
15CDK121.78890227
16IRAK31.72595210
17TYK21.71736608
18TNK21.68702223
19JAK11.65289179
20MAP3K131.64282068
21SIK31.63783603
22SGK31.62281142
23MAP3K101.60907635
24MAP3K71.57997650
25FES1.48926537
26TXK1.47542361
27ZAP701.45122582
28SGK21.41131621
29MAP3K11.39425722
30CAMK1D1.35046567
31FGR1.33862470
32PKN21.32335029
33SMG11.30750293
34CAMK1G1.28686744
35KSR21.28122119
36PTK61.27917670
37RIPK11.26589172
38JAK31.23981672
39ICK1.20879157
40JAK21.12360343
41MAP2K31.09225490
42BRD41.07498933
43SGK4941.06861483
44SGK2231.06861483
45IRAK11.05722816
46IKBKE1.05616428
47MATK1.04975134
48SIK21.04546362
49WNK11.03116486
50IRAK21.03014237
51TTN1.01906308
52TBK11.01428608
53TGFBR21.00983737
54NEK11.00642482
55PRKAA10.97996917
56PRKCH0.96501735
57EPHB10.94862397
58EPHA30.93201719
59GRK60.93189593
60CSK0.93156231
61TAOK10.92871178
62PDK40.92661766
63PDK30.92661766
64LYN0.92637438
65MTOR0.92348071
66MAPK110.87548199
67ITK0.87487986
68PRKAA20.87372951
69NEK90.85088394
70MAP3K20.84763240
71MAP3K60.83956855
72STK380.82799520
73FLT30.82207128
74KIT0.78272705
75FGFR30.77719920
76CHUK0.77329168
77YES10.76570599
78TESK20.75760143
79PIK3CG0.74855304
80BTK0.73836286
81EEF2K0.72508321
82CAMKK10.67988175
83CSF1R0.67576785
84BLK0.67266400
85HCK0.62382668
86BMPR20.60816224
87PINK10.59855750
88MAPK150.58291883
89TEC0.57843633
90DYRK1B0.57732729
91SYK0.56861160
92STK100.56664218
93LATS10.56177217
94RET0.55789122
95GSK3A0.55776572
96SGK10.54675683
97PTK20.54477298
98PDK10.54293866
99MAP3K30.52437916
100LCK0.51708718
101CDK60.51392172
102IRAK40.50900520
103IKBKB0.49122589
104CAMK40.48868336
105HIPK20.48843171
106MARK30.48216323
107CDC42BPA0.48038097
108MAPK70.47705752
109FYN0.46033878
110NLK0.45703439
111LRRK20.45698627
112MAPK120.45649693
113PRKD20.45413351
114MAP3K110.45148593
115RPS6KC10.45087287
116RPS6KL10.45087287
117PIM10.44116038
118MAP2K60.44032787
119MARK20.42031672
120PDK20.40957218
121MAP2K20.38916787
122PTK2B0.38891204
123PDGFRB0.38805927
124PDGFRA0.38162892
125CDK40.37573407
126MAPKAPK20.37193497
127PDPK10.37162599
128NEK20.35156708
129MAP3K50.34589969
130MELK0.33703659
131RPS6KA20.33222014
132RPS6KA60.33200909
133TAOK20.33090359
134BMX0.32792103

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.86632169
2Tryptophan metabolism_Homo sapiens_hsa003802.85637447
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84779245
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82759263
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76693585
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.75566545
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.73769625
8Fatty acid degradation_Homo sapiens_hsa000712.70973530
9Nitrogen metabolism_Homo sapiens_hsa009102.53898118
10Propanoate metabolism_Homo sapiens_hsa006402.47858443
11Leishmaniasis_Homo sapiens_hsa051402.47739765
12Butanoate metabolism_Homo sapiens_hsa006502.47710975
13Arginine biosynthesis_Homo sapiens_hsa002202.46618030
14Lysine degradation_Homo sapiens_hsa003102.24870032
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.24004380
16Peroxisome_Homo sapiens_hsa041462.16526230
17Selenocompound metabolism_Homo sapiens_hsa004502.05735384
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03425626
19Fatty acid metabolism_Homo sapiens_hsa012121.99491797
20Bile secretion_Homo sapiens_hsa049761.91751193
21PPAR signaling pathway_Homo sapiens_hsa033201.90618480
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.87439205
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83319387
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82926438
25beta-Alanine metabolism_Homo sapiens_hsa004101.80568655
26Tuberculosis_Homo sapiens_hsa051521.79479747
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78394176
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77732108
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70595254
30Graft-versus-host disease_Homo sapiens_hsa053321.67456350
31TNF signaling pathway_Homo sapiens_hsa046681.67433423
32Vitamin digestion and absorption_Homo sapiens_hsa049771.66609499
33Malaria_Homo sapiens_hsa051441.65630679
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62958264
35Allograft rejection_Homo sapiens_hsa053301.62660046
36ABC transporters_Homo sapiens_hsa020101.62475048
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60692028
38Influenza A_Homo sapiens_hsa051641.60159556
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.53758790
40Toxoplasmosis_Homo sapiens_hsa051451.53346522
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48346690
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45240901
43Complement and coagulation cascades_Homo sapiens_hsa046101.44477598
44Autoimmune thyroid disease_Homo sapiens_hsa053201.42912479
45Chemokine signaling pathway_Homo sapiens_hsa040621.42612959
46Non-small cell lung cancer_Homo sapiens_hsa052231.42304884
47Pyruvate metabolism_Homo sapiens_hsa006201.37615940
48Hepatitis B_Homo sapiens_hsa051611.34148205
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.33678795
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33611509
51Carbon metabolism_Homo sapiens_hsa012001.33323016
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29203745
53Hematopoietic cell lineage_Homo sapiens_hsa046401.28401515
54Herpes simplex infection_Homo sapiens_hsa051681.27106467
55Pancreatic cancer_Homo sapiens_hsa052121.26833155
56Legionellosis_Homo sapiens_hsa051341.22954576
57Sulfur metabolism_Homo sapiens_hsa009201.22372899
58VEGF signaling pathway_Homo sapiens_hsa043701.22085031
59Biosynthesis of amino acids_Homo sapiens_hsa012301.22062322
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.20967838
61Staphylococcus aureus infection_Homo sapiens_hsa051501.18783086
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18258908
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17800007
64Pertussis_Homo sapiens_hsa051331.15853901
65Starch and sucrose metabolism_Homo sapiens_hsa005001.14458318
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09467538
67African trypanosomiasis_Homo sapiens_hsa051431.08612173
68Viral myocarditis_Homo sapiens_hsa054161.07371988
69Neurotrophin signaling pathway_Homo sapiens_hsa047221.06382119
70Prolactin signaling pathway_Homo sapiens_hsa049171.05969197
71Notch signaling pathway_Homo sapiens_hsa043301.05070854
72Antigen processing and presentation_Homo sapiens_hsa046121.04786255
73Glycerolipid metabolism_Homo sapiens_hsa005611.04434428
74Renal cell carcinoma_Homo sapiens_hsa052111.02024397
75Sulfur relay system_Homo sapiens_hsa041221.01917059
76Type I diabetes mellitus_Homo sapiens_hsa049401.01865539
77Cysteine and methionine metabolism_Homo sapiens_hsa002701.01317603
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00685585
79Apoptosis_Homo sapiens_hsa042101.00081224
80Caffeine metabolism_Homo sapiens_hsa002320.97749066
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93743088
82Histidine metabolism_Homo sapiens_hsa003400.91608400
83Salmonella infection_Homo sapiens_hsa051320.91418796
84Insulin resistance_Homo sapiens_hsa049310.91258558
85Shigellosis_Homo sapiens_hsa051310.91256169
86Phenylalanine metabolism_Homo sapiens_hsa003600.90478197
87Endometrial cancer_Homo sapiens_hsa052130.89604945
88Chemical carcinogenesis_Homo sapiens_hsa052040.89388863
89Phagosome_Homo sapiens_hsa041450.88154745
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88102481
91Platelet activation_Homo sapiens_hsa046110.88001851
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.87480171
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84448892
94Amoebiasis_Homo sapiens_hsa051460.83152836
95Arginine and proline metabolism_Homo sapiens_hsa003300.80516807
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.80007338
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79733889
98Folate biosynthesis_Homo sapiens_hsa007900.78882599
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.77487142
100Fructose and mannose metabolism_Homo sapiens_hsa000510.77342514
101FoxO signaling pathway_Homo sapiens_hsa040680.76952492
102Choline metabolism in cancer_Homo sapiens_hsa052310.76557791
103mTOR signaling pathway_Homo sapiens_hsa041500.76340707
104Rheumatoid arthritis_Homo sapiens_hsa053230.76204311
105GnRH signaling pathway_Homo sapiens_hsa049120.74507933
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74232660
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74022168
108Endocytosis_Homo sapiens_hsa041440.72754292
109Other glycan degradation_Homo sapiens_hsa005110.72273753
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.71105004
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.68180490
112One carbon pool by folate_Homo sapiens_hsa006700.67925306
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67552084
114Prostate cancer_Homo sapiens_hsa052150.66877251
115ErbB signaling pathway_Homo sapiens_hsa040120.66396061
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66083875
117Viral carcinogenesis_Homo sapiens_hsa052030.65415123
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65230842
119Primary immunodeficiency_Homo sapiens_hsa053400.64861955
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.64671161
121Epstein-Barr virus infection_Homo sapiens_hsa051690.64401935
122Bladder cancer_Homo sapiens_hsa052190.64359534
123Asthma_Homo sapiens_hsa053100.63503943
124Dorso-ventral axis formation_Homo sapiens_hsa043200.62792079
125HTLV-I infection_Homo sapiens_hsa051660.62182458
126HIF-1 signaling pathway_Homo sapiens_hsa040660.61843117
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59854964
128Colorectal cancer_Homo sapiens_hsa052100.59492930
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58674751
130Lysosome_Homo sapiens_hsa041420.56321383
131Retinol metabolism_Homo sapiens_hsa008300.56139651
132Pentose phosphate pathway_Homo sapiens_hsa000300.55438556
133Tyrosine metabolism_Homo sapiens_hsa003500.55334207
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.54385352
135MAPK signaling pathway_Homo sapiens_hsa040100.52547755
136Fat digestion and absorption_Homo sapiens_hsa049750.52345928
137Glioma_Homo sapiens_hsa052140.52319028
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52003830
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50943051
140Glutathione metabolism_Homo sapiens_hsa004800.50668647
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50122483
142Type II diabetes mellitus_Homo sapiens_hsa049300.50090886
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48749623
144Small cell lung cancer_Homo sapiens_hsa052220.48178319
145Prion diseases_Homo sapiens_hsa050200.47890085
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47450227
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45225978
148Protein digestion and absorption_Homo sapiens_hsa049740.44897796
149Estrogen signaling pathway_Homo sapiens_hsa049150.43242391
150Fatty acid biosynthesis_Homo sapiens_hsa000610.43176352
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42437701
152B cell receptor signaling pathway_Homo sapiens_hsa046620.40571560
153Fatty acid elongation_Homo sapiens_hsa000620.36943898
154Glucagon signaling pathway_Homo sapiens_hsa049220.36595779
155Hepatitis C_Homo sapiens_hsa051600.35723403
156Vitamin B6 metabolism_Homo sapiens_hsa007500.35464733
157Intestinal immune network for IgA production_Homo sapiens_hsa046720.34894617
158AMPK signaling pathway_Homo sapiens_hsa041520.34097638
159Galactose metabolism_Homo sapiens_hsa000520.29804415
160Acute myeloid leukemia_Homo sapiens_hsa052210.28030198
161Insulin signaling pathway_Homo sapiens_hsa049100.26279482
162Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23949114
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23608268
164RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23449546
165Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22919155
166Osteoclast differentiation_Homo sapiens_hsa043800.21409352
167Mineral absorption_Homo sapiens_hsa049780.20221054
168Measles_Homo sapiens_hsa051620.19980066
169T cell receptor signaling pathway_Homo sapiens_hsa046600.19461180
170Inositol phosphate metabolism_Homo sapiens_hsa005620.18985805
171Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18560373
172Metabolic pathways_Homo sapiens_hsa011000.17863005
173Renin-angiotensin system_Homo sapiens_hsa046140.14983743
174Chronic myeloid leukemia_Homo sapiens_hsa052200.14574349
175Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14152260

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