SLC9A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sodium/proton exchanger that is a member of the solute carrier 9 protein family. The encoded protein localizes the to the late recycling endosomes and may play an important role in maintaining cation homeostasis. Mutations in this gene are associated with autism susceptibility 16 and attention-deficit/hyperactivity disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.01657635
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.01657635
3positive regulation by symbiont of host defense response (GO:0052509)4.66664308
4modulation by symbiont of host defense response (GO:0052031)4.66664308
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.66664308
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.66664308
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.66664308
8modulation by symbiont of host immune response (GO:0052553)4.66664308
9regulation of B cell receptor signaling pathway (GO:0050855)4.47625189
10microglial cell activation (GO:0001774)4.45754295
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.37986111
12regulation of interferon-beta biosynthetic process (GO:0045357)4.33472118
13positive regulation of gamma-delta T cell activation (GO:0046645)4.18769555
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.04045528
15negative regulation of interleukin-12 production (GO:0032695)3.79663975
16positive regulation of mast cell activation (GO:0033005)3.78114592
17macrophage activation involved in immune response (GO:0002281)3.76759190
18positive thymic T cell selection (GO:0045059)3.69941704
19neutrophil activation involved in immune response (GO:0002283)3.68137569
20positive regulation of cellular amide metabolic process (GO:0034250)3.63862322
21purinergic nucleotide receptor signaling pathway (GO:0035590)3.62089240
22positive regulation of macrophage differentiation (GO:0045651)3.55412701
23positive T cell selection (GO:0043368)3.51948064
24regulation of T cell tolerance induction (GO:0002664)3.51578211
25regulation of mast cell degranulation (GO:0043304)3.44176419
26mast cell activation (GO:0045576)3.40709533
27regulation of mast cell activation (GO:0033003)3.39784325
28detection of other organism (GO:0098543)3.36748116
29negative T cell selection (GO:0043383)3.36000274
30positive regulation of mast cell degranulation (GO:0043306)3.33693662
31positive regulation of mast cell activation involved in immune response (GO:0033008)3.33693662
32adenosine receptor signaling pathway (GO:0001973)3.31815466
33regulation of mast cell activation involved in immune response (GO:0033006)3.25780448
34antigen processing and presentation of endogenous antigen (GO:0019883)3.24795744
35negative regulation of bone resorption (GO:0045779)3.24193418
36regulation of isotype switching to IgG isotypes (GO:0048302)3.21851467
37regulation of platelet activation (GO:0010543)3.21008630
38immunoglobulin mediated immune response (GO:0016064)3.20248291
39negative regulation of interleukin-17 production (GO:0032700)3.20140769
40detection of molecule of bacterial origin (GO:0032490)3.19467904
41negative regulation of granulocyte differentiation (GO:0030853)3.18426266
42regulation of platelet aggregation (GO:0090330)3.18055373
43myeloid cell activation involved in immune response (GO:0002275)3.17858473
44B cell mediated immunity (GO:0019724)3.17844773
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16530419
46cellular response to thyroid hormone stimulus (GO:0097067)3.12260207
47response to host immune response (GO:0052572)3.12242519
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12242519
49detection of bacterium (GO:0016045)3.11943394
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.11697313
51macrophage activation (GO:0042116)3.10190864
52negative thymic T cell selection (GO:0045060)3.10076463
53positive regulation of B cell differentiation (GO:0045579)3.09593123
54detection of external biotic stimulus (GO:0098581)3.07540696
55neurofilament cytoskeleton organization (GO:0060052)3.04105232
56pinocytosis (GO:0006907)3.02400290
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02344871
58regulation of B cell differentiation (GO:0045577)3.01925958
59positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.00351225
60positive regulation of smooth muscle cell migration (GO:0014911)2.98985568
61positive regulation of antigen processing and presentation (GO:0002579)2.97346287
62regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93054109
63response to acidic pH (GO:0010447)2.91203394
64germinal center formation (GO:0002467)2.91057783
65T cell migration (GO:0072678)2.90904625
66response to host (GO:0075136)2.90506021
67response to host defenses (GO:0052200)2.90506021
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90506021
69detection of temperature stimulus involved in sensory perception (GO:0050961)2.90314312
70detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.90314312
71regulation of hypersensitivity (GO:0002883)2.88607330
72interferon-gamma production (GO:0032609)2.86879208
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86419401
74leukocyte aggregation (GO:0070486)2.85740541
75positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.84535675
76purinergic receptor signaling pathway (GO:0035587)2.83033931
77regulation of T-helper 2 cell differentiation (GO:0045628)2.81173455
78regulation of leukocyte degranulation (GO:0043300)2.80924659
79positive regulation of interferon-alpha production (GO:0032727)2.80666087
80negative regulation of mast cell activation (GO:0033004)2.79760618
81cellular extravasation (GO:0045123)2.79315762
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78899310
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.78276932
84activated T cell proliferation (GO:0050798)2.77292390
85regulation of gamma-delta T cell differentiation (GO:0045586)2.76189300
86B cell receptor signaling pathway (GO:0050853)2.76134446
87detection of temperature stimulus (GO:0016048)2.74782451
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73671394
89phagocytosis, engulfment (GO:0006911)2.72123540
90regulation of regulatory T cell differentiation (GO:0045589)2.71717373
91detection of biotic stimulus (GO:0009595)2.71657298
92positive regulation of immunoglobulin mediated immune response (GO:0002891)2.71506989
93positive regulation of B cell mediated immunity (GO:0002714)2.71506989
94G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.71315226
95regulation of mononuclear cell migration (GO:0071675)2.69941073
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.68578447
97regulation of interferon-alpha production (GO:0032647)2.68207414
98regulation of macrophage chemotaxis (GO:0010758)2.67883864
99peripheral nervous system neuron development (GO:0048935)2.67286777
100amyloid precursor protein catabolic process (GO:0042987)2.67045405
101negative regulation of bone remodeling (GO:0046851)2.66865549
102regulation of gamma-delta T cell activation (GO:0046643)2.66856573
103response to peptidoglycan (GO:0032494)2.66754132
104positive regulation of type 2 immune response (GO:0002830)2.64408143
105T-helper 1 type immune response (GO:0042088)2.64288275
106tolerance induction (GO:0002507)2.63917669
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63491242
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62968100
109regulation of interleukin-17 production (GO:0032660)2.62533398
110negative regulation of T cell mediated immunity (GO:0002710)2.62373868
111T cell costimulation (GO:0031295)2.62075055
112type I interferon signaling pathway (GO:0060337)2.61926455
113cellular response to type I interferon (GO:0071357)2.61926455
114response to type I interferon (GO:0034340)2.61921338
115regulation of T-helper 1 cell differentiation (GO:0045625)2.61665139
116neutrophil activation (GO:0042119)2.61128595
117thrombin receptor signaling pathway (GO:0070493)2.59747415
118positive regulation of monocyte chemotaxis (GO:0090026)2.59108834
119negative regulation of cytokine production involved in immune response (GO:0002719)2.59051353
120leukocyte degranulation (GO:0043299)2.58987035
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.58462979
122dendritic cell chemotaxis (GO:0002407)2.58419033
123respiratory burst (GO:0045730)2.57817582
124lymphocyte costimulation (GO:0031294)2.57803184
125peptide catabolic process (GO:0043171)2.57739892
126positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.57045962
127positive regulation of leukocyte degranulation (GO:0043302)2.55725783
128interferon-gamma-mediated signaling pathway (GO:0060333)2.55697975
129regulation of tolerance induction (GO:0002643)2.55290351
130myeloid leukocyte activation (GO:0002274)2.54316457
131positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.51808762
132positive regulation of alpha-beta T cell proliferation (GO:0046641)2.50771482
133mast cell activation involved in immune response (GO:0002279)2.49873065
134mast cell degranulation (GO:0043303)2.49873065
135negative regulation of B cell proliferation (GO:0030889)2.48196911
136negative regulation of tissue remodeling (GO:0034104)2.46475530
137regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.46328677
138regulation of alpha-beta T cell proliferation (GO:0046640)2.45794805
139granulocyte activation (GO:0036230)2.44772251
140regulation of amyloid precursor protein catabolic process (GO:1902991)2.44306474
141regulation of antigen processing and presentation (GO:0002577)2.44169036
142regulation of beta-amyloid formation (GO:1902003)2.42988179
143thymic T cell selection (GO:0045061)2.42741831
144T cell selection (GO:0045058)2.42032181
145regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.42018513
146negative regulation of interleukin-6 production (GO:0032715)2.41531508
147regulation of neutrophil migration (GO:1902622)2.39996344
148regulation of neutrophil chemotaxis (GO:0090022)2.39996344
149negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.39008434
150monocyte chemotaxis (GO:0002548)2.38701478
151positive regulation of isotype switching (GO:0045830)2.38080598
152lipoxygenase pathway (GO:0019372)2.36229731
153response to lipoprotein particle (GO:0055094)2.35743169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.06544669
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.59977558
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.21684185
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.68039404
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.48748138
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.41642739
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33390308
8RUNX_20019798_ChIP-Seq_JUKART_Human2.86421954
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.69147454
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60278373
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55421741
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.47398380
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47267158
14GBX2_23144817_ChIP-Seq_PC3_Human2.17706459
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15361494
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91221931
17SPI1_23127762_ChIP-Seq_K562_Human1.89145435
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80656943
19GATA1_22025678_ChIP-Seq_K562_Human1.78570681
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.77777660
21VDR_24787735_ChIP-Seq_THP-1_Human1.75746704
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74395758
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71920075
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65788744
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64344197
26SCL_19346495_ChIP-Seq_HPC-7_Human1.62036493
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.59370409
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54035447
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.53152204
30GATA1_19941826_ChIP-Seq_K562_Human1.52909182
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49635057
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48792400
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45753537
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42428414
35NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.42021819
36VDR_24763502_ChIP-Seq_THP-1_Human1.39360729
37TAF15_26573619_Chip-Seq_HEK293_Human1.36890986
38MYB_26560356_Chip-Seq_TH2_Human1.36353136
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35134321
40SPI1_23547873_ChIP-Seq_NB4_Human1.34591610
41PU_27001747_Chip-Seq_BMDM_Mouse1.33630525
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32887452
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.29258134
44* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25870732
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24804278
46AHR_22903824_ChIP-Seq_MCF-7_Human1.23292263
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22454357
48AR_21572438_ChIP-Seq_LNCaP_Human1.22293065
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21026965
50* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19852336
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17052343
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15409142
53EGR1_19032775_ChIP-ChIP_M12_Human1.14997230
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11140256
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09984833
56* DROSHA_22980978_ChIP-Seq_HELA_Human1.08967329
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08638418
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05119576
59UTX_26944678_Chip-Seq_JUKART_Human1.05103472
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04934830
61MAF_26560356_Chip-Seq_TH1_Human1.03033264
62* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01939440
63MYB_26560356_Chip-Seq_TH1_Human1.01811926
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00503948
65* GATA3_27048872_Chip-Seq_THYMUS_Human0.99812966
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99392584
67ARNT_22903824_ChIP-Seq_MCF-7_Human0.97263403
68GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96877829
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96873823
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95606215
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95025117
72ESR2_21235772_ChIP-Seq_MCF-7_Human0.94181551
73GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92247083
74SMRT_27268052_Chip-Seq_Bcells_Human0.91383407
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90315477
76* GATA3_26560356_Chip-Seq_TH2_Human0.89774682
77* P300_19829295_ChIP-Seq_ESCs_Human0.88952398
78GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88487873
79GATA2_19941826_ChIP-Seq_K562_Human0.87982074
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87753131
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87023913
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.86284705
83* PRDM14_20953172_ChIP-Seq_ESCs_Human0.86196983
84STAT1_20625510_ChIP-Seq_HELA_Human0.86123392
85CMYC_18555785_Chip-Seq_ESCs_Mouse0.85182732
86EGR1_19374776_ChIP-ChIP_THP-1_Human0.84289648
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84092594
88AR_25329375_ChIP-Seq_VCAP_Human0.84012381
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83746841
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83746841
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83681025
92PU1_27457419_Chip-Seq_LIVER_Mouse0.83268176
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82980924
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82795556
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82627207
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82203752
97CJUN_26792858_Chip-Seq_BT549_Human0.81858138
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81692068
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81250163
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81237134
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81130950
102SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81119317
103NANOG_18555785_Chip-Seq_ESCs_Mouse0.81055765
104ESR1_20079471_ChIP-ChIP_T-47D_Human0.80210281
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79668292
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79416602
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.79143798
108TP53_16413492_ChIP-PET_HCT116_Human0.79121112
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79046608
110MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78762152
111KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.78595183
112* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78564045
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78454933
114E2F1_18555785_Chip-Seq_ESCs_Mouse0.77499615
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75892594
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75579856
117TP53_18474530_ChIP-ChIP_U2OS_Human0.75246401
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75010243
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73662661
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73652800
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72276801
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.69280582
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.66770835
124TCF7_22412390_ChIP-Seq_EML_Mouse0.65565959
125VDR_21846776_ChIP-Seq_THP-1_Human0.65531492
126LXR_22158963_ChIP-Seq_LIVER_Mouse0.64173339
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63515626
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62312020
129* BCAT_22108803_ChIP-Seq_LS180_Human0.62071871
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.61948519
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.61828190
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.61279149
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.60162653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.40994762
2MP0005058_abnormal_lysosome_morphology4.03747012
3MP0005671_abnormal_response_to3.09326405
4MP0006082_CNS_inflammation3.07689549
5MP0002419_abnormal_innate_immunity2.59112869
6MP0002735_abnormal_chemical_nociception2.54508340
7MP0005000_abnormal_immune_tolerance2.53363923
8MP0003172_abnormal_lysosome_physiology2.51758821
9MP0002148_abnormal_hypersensitivity_rea2.47326021
10MP0008004_abnormal_stomach_pH2.46915891
11MP0000015_abnormal_ear_pigmentation2.34423937
12MP0000569_abnormal_digit_pigmentation2.32154022
13MP0009840_abnormal_foam_cell2.29338739
14MP0001986_abnormal_taste_sensitivity2.27787373
15MP0000920_abnormal_myelination2.24849707
16MP0001800_abnormal_humoral_immune2.22070134
17MP0003690_abnormal_glial_cell2.21642548
18MP0005387_immune_system_phenotype2.18768441
19MP0001790_abnormal_immune_system2.18768441
20MP0002723_abnormal_immune_serum2.14013660
21MP0002452_abnormal_antigen_presenting2.11003627
22MP0003183_abnormal_peptide_metabolism2.10401156
23MP0005025_abnormal_response_to2.08908602
24MP0003763_abnormal_thymus_physiology2.05411367
25MP0009785_altered_susceptibility_to2.03613519
26MP0000685_abnormal_immune_system2.01092615
27MP0005464_abnormal_platelet_physiology1.98192510
28MP0002405_respiratory_system_inflammati1.97910197
29MP0003191_abnormal_cellular_cholesterol1.94017076
30MP0002420_abnormal_adaptive_immunity1.93921847
31MP0004510_myositis1.93090397
32MP0001819_abnormal_immune_cell1.92102862
33MP0003724_increased_susceptibility_to1.92005037
34MP0000604_amyloidosis1.88803190
35MP0005409_darkened_coat_color1.83831542
36MP0003436_decreased_susceptibility_to1.79385917
37MP0005174_abnormal_tail_pigmentation1.77750340
38MP0002736_abnormal_nociception_after1.76204730
39MP0005167_abnormal_blood-brain_barrier1.72294904
40MP0001968_abnormal_touch/_nociception1.71869475
41MP0002166_altered_tumor_susceptibility1.71513256
42MP0003300_gastrointestinal_ulcer1.71287665
43MP0005310_abnormal_salivary_gland1.65322370
44MP0003828_pulmonary_edema1.58460186
45MP0003075_altered_response_to1.50960647
46MP0004947_skin_inflammation1.48861986
47MP0000465_gastrointestinal_hemorrhage1.47539900
48MP0006054_spinal_hemorrhage1.45818760
49MP0009333_abnormal_splenocyte_physiolog1.44728480
50MP0001851_eye_inflammation1.42270738
51MP0000716_abnormal_immune_system1.41259261
52MP0002998_abnormal_bone_remodeling1.36337494
53MP0001533_abnormal_skeleton_physiology1.35780216
54MP0001873_stomach_inflammation1.31209482
55MP0009278_abnormal_bone_marrow1.29580412
56MP0002398_abnormal_bone_marrow1.29555598
57MP0001845_abnormal_inflammatory_respons1.28134119
58MP0000689_abnormal_spleen_morphology1.21877407
59MP0001545_abnormal_hematopoietic_system1.21094299
60MP0005397_hematopoietic_system_phenotyp1.21094299
61MP0004147_increased_porphyrin_level1.20669381
62MP0001970_abnormal_pain_threshold1.18940805
63MP0002006_tumorigenesis1.18767339
64MP0004270_analgesia1.18563663
65MP0003634_abnormal_glial_cell1.16546065
66MP0005166_decreased_susceptibility_to1.15718691
67MP0002733_abnormal_thermal_nociception1.15444118
68MP0009763_increased_sensitivity_to1.14432690
69MP0003045_fibrosis1.13593474
70MP0009764_decreased_sensitivity_to1.12997828
71MP0001984_abnormal_olfaction1.12026321
72MP0002009_preneoplasia1.10434609
73MP0010155_abnormal_intestine_physiology1.09376648
74MP0000249_abnormal_blood_vessel1.08476934
75MP0008469_abnormal_protein_level1.05115787
76MP0002933_joint_inflammation1.04055977
77MP0003329_amyloid_beta_deposits1.03456779
78MP0003633_abnormal_nervous_system1.03188750
79MP0005164_abnormal_response_to1.02788995
80MP0003279_aneurysm1.02538983
81MP0002429_abnormal_blood_cell1.02387544
82MP0002722_abnormal_immune_system1.00691965
83MP0004381_abnormal_hair_follicle1.00327435
84MP0001853_heart_inflammation0.97143868
85MP0004858_abnormal_nervous_system0.94608498
86MP0002734_abnormal_mechanical_nocicepti0.94270696
87MP0008260_abnormal_autophagy0.94028307
88MP0002095_abnormal_skin_pigmentation0.93238765
89MP0000372_irregular_coat_pigmentation0.91753833
90MP0005275_abnormal_skin_tensile0.91715526
91MP0006276_abnormal_autonomic_nervous0.90285115
92MP0005165_increased_susceptibility_to0.90121059
93MP0003448_altered_tumor_morphology0.89410119
94MP0000703_abnormal_thymus_morphology0.86052396
95MP0008874_decreased_physiological_sensi0.85603217
96MP0002396_abnormal_hematopoietic_system0.85453413
97MP0005390_skeleton_phenotype0.84795916
98MP0005595_abnormal_vascular_smooth0.82454628
99MP0004883_abnormal_blood_vessel0.82414964
100MP0003303_peritoneal_inflammation0.81818860
101MP0001542_abnormal_bone_strength0.81376696
102MP0000858_altered_metastatic_potential0.81112862
103MP0004130_abnormal_muscle_cell0.77998963
104MP0000343_altered_response_to0.77853643
105MP0005075_abnormal_melanosome_morpholog0.77731107
106MP0003091_abnormal_cell_migration0.77206570
107MP0000230_abnormal_systemic_arterial0.75870650
108MP0002229_neurodegeneration0.75734264
109MP0003806_abnormal_nucleotide_metabolis0.73982029
110MP0001663_abnormal_digestive_system0.73487123
111MP0002090_abnormal_vision0.73476242
112MP0002332_abnormal_exercise_endurance0.73230018
113MP0002272_abnormal_nervous_system0.72924361
114MP0003631_nervous_system_phenotype0.70932408
115MP0009765_abnormal_xenobiotic_induced0.69050120
116MP0005646_abnormal_pituitary_gland0.68269639
117MP0004742_abnormal_vestibular_system0.67973598
118MP0003866_abnormal_defecation0.67737547
119MP0005023_abnormal_wound_healing0.67129683
120MP0002067_abnormal_sensory_capabilities0.62779206
121MP0002139_abnormal_hepatobiliary_system0.62606793
122MP0008438_abnormal_cutaneous_collagen0.61356515
123MP0005647_abnormal_sex_gland0.61019456
124MP0003795_abnormal_bone_structure0.60418715
125MP0003453_abnormal_keratinocyte_physiol0.59561988
126MP0001905_abnormal_dopamine_level0.59508261
127MP0003656_abnormal_erythrocyte_physiolo0.59363063
128MP0008569_lethality_at_weaning0.58922450
129MP0002132_abnormal_respiratory_system0.58157880
130MP0004484_altered_response_of0.55637348
131MP0003638_abnormal_response/metabolism_0.54971599
132MP0005535_abnormal_body_temperature0.54591086
133MP0005365_abnormal_bile_salt0.52006896

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.59713957
2Recurrent abscess formation (HP:0002722)5.12777117
3Glomerulonephritis (HP:0000099)4.88297183
4Eczematoid dermatitis (HP:0000976)4.83374086
5Prolonged bleeding time (HP:0003010)4.72493285
6Dysostosis multiplex (HP:0000943)4.68801729
7Petechiae (HP:0000967)4.55595627
8Purpura (HP:0000979)4.54389760
9Recurrent bacterial skin infections (HP:0005406)4.43634857
10Ulnar claw (HP:0001178)4.43041614
11Increased cerebral lipofuscin (HP:0011813)4.17407413
12Increased neuronal autofluorescent lipopigment (HP:0002074)4.15842102
13Epistaxis (HP:0000421)4.01659333
14Neurofibrillary tangles (HP:0002185)4.00744116
15Elevated erythrocyte sedimentation rate (HP:0003565)3.92455554
16Vacuolated lymphocytes (HP:0001922)3.85059458
17Segmental peripheral demyelination/remyelination (HP:0003481)3.83273476
18Gingival bleeding (HP:0000225)3.71145999
19Stomatitis (HP:0010280)3.70788042
20Abnormality of the vasculature of the conjunctiva (HP:0008054)3.68683137
21Abnormality of liposaccharide metabolism (HP:0010968)3.63087706
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.63087706
23Abnormality of glycolipid metabolism (HP:0010969)3.63087706
24Complement deficiency (HP:0004431)3.52381433
25Axonal loss (HP:0003447)3.51312762
26Abnormal platelet volume (HP:0011876)3.48706387
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.38804177
28Thyroiditis (HP:0100646)3.31490731
29Increased mean platelet volume (HP:0011877)3.30779312
30Conjunctival telangiectasia (HP:0000524)3.26077506
31Myositis (HP:0100614)3.25601446
32Prostate neoplasm (HP:0100787)3.23396247
33Menorrhagia (HP:0000132)3.13745122
34Hypoplasia of the thymus (HP:0000778)3.12296035
35T lymphocytopenia (HP:0005403)3.12015400
36Supranuclear gaze palsy (HP:0000605)3.08813754
37Recurrent gram-negative bacterial infections (HP:0005420)2.97332998
38Severe combined immunodeficiency (HP:0004430)2.93137988
39Abnormality of T cell number (HP:0011839)2.90556067
40Abnormality of complement system (HP:0005339)2.85501737
41Recurrent skin infections (HP:0001581)2.83383287
42Autoimmune thrombocytopenia (HP:0001973)2.82967234
43Optic neuritis (HP:0100653)2.80350827
44Retrobulbar optic neuritis (HP:0100654)2.80350827
45Eosinophilia (HP:0001880)2.77781092
46Disinhibition (HP:0000734)2.77376435
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74933028
48Abnormality of polysaccharide metabolism (HP:0011012)2.74933028
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74933028
50Mucopolysacchariduria (HP:0008155)2.71953036
51Urinary glycosaminoglycan excretion (HP:0003541)2.71953036
52Agnosia (HP:0010524)2.70545381
53Panhypogammaglobulinemia (HP:0003139)2.70349986
54Recurrent fungal infections (HP:0002841)2.69617909
55Abnormality of B cell number (HP:0010975)2.64144375
56B lymphocytopenia (HP:0010976)2.64144375
57Basal ganglia calcification (HP:0002135)2.62611775
58Cerebral inclusion bodies (HP:0100314)2.62188693
59Hepatosplenomegaly (HP:0001433)2.61069761
60Encephalitis (HP:0002383)2.58798221
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56478611
62Abnormal platelet function (HP:0011869)2.53985038
63Impaired platelet aggregation (HP:0003540)2.53985038
64Submucous cleft hard palate (HP:0000176)2.52224886
65Onion bulb formation (HP:0003383)2.51494493
66Hemoptysis (HP:0002105)2.51297107
67Abnormality of macrophages (HP:0004311)2.51141177
68Recurrent viral infections (HP:0004429)2.49024417
69Orchitis (HP:0100796)2.48739448
70Thick nail (HP:0001805)2.47413581
71Autoimmune hemolytic anemia (HP:0001890)2.47376093
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.45912423
73Nephritis (HP:0000123)2.44592036
74Mediastinal lymphadenopathy (HP:0100721)2.44360314
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.42836484
76Osteolytic defects of the hand bones (HP:0009699)2.42836484
77Increased IgM level (HP:0003496)2.42210001
78Abnormality of eosinophils (HP:0001879)2.37428525
79Leukocytosis (HP:0001974)2.36711238
80Peripheral demyelination (HP:0011096)2.36338423
81Keratoconjunctivitis sicca (HP:0001097)2.32276350
82Gingivitis (HP:0000230)2.30142328
83Abnormality of T cells (HP:0002843)2.30003735
84Loss of speech (HP:0002371)2.29883189
85Action tremor (HP:0002345)2.27747607
86Abnormality of binocular vision (HP:0011514)2.27116412
87Diplopia (HP:0000651)2.27116412
88Chest pain (HP:0100749)2.26813896
89Pulmonary embolism (HP:0002204)2.24877422
90Pustule (HP:0200039)2.23292094
91Urticaria (HP:0001025)2.22319831
92Combined immunodeficiency (HP:0005387)2.20781656
93Colitis (HP:0002583)2.20271004
94Vasculitis (HP:0002633)2.20074076
95Abnormality of the prostate (HP:0008775)2.17792806
96Chronic obstructive pulmonary disease (HP:0006510)2.17392288
97Obstructive lung disease (HP:0006536)2.17392288
98Joint swelling (HP:0001386)2.17162452
99Stomach cancer (HP:0012126)2.16458818
100Gastrointestinal inflammation (HP:0004386)2.16073565
101IgM deficiency (HP:0002850)2.10337569
102Hypothermia (HP:0002045)2.10130384
103Disproportionate tall stature (HP:0001519)2.09787018
104Mutism (HP:0002300)2.09142284
105Neuronal loss in central nervous system (HP:0002529)2.08898800
106Arterial thrombosis (HP:0004420)2.08408872
107Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.08206673
108Keratoconjunctivitis (HP:0001096)2.07861040
109Hematochezia (HP:0002573)2.06532787
110Polyneuropathy (HP:0001271)2.06378474
111Arterial tortuosity (HP:0005116)2.03010794
112Vertigo (HP:0002321)2.02251475
113Hypoproteinemia (HP:0003075)2.01943650
114Pulmonary infiltrates (HP:0002113)2.00756820
115Abnormality of iron homeostasis (HP:0011031)1.99437724
116J-shaped sella turcica (HP:0002680)1.98530218
117Chronic diarrhea (HP:0002028)1.96993152
118Peripheral hypomyelination (HP:0007182)1.96791469
119Apathy (HP:0000741)1.95504422
120Polycythemia (HP:0001901)1.95193330
121Slow saccadic eye movements (HP:0000514)1.95120336
122Increased serum ferritin (HP:0003281)1.94641427
123Mucosal telangiectasiae (HP:0100579)1.94320992
124Spontaneous hematomas (HP:0007420)1.94313610
125Granulocytopenia (HP:0001913)1.94055619
126Hyperlipoproteinemia (HP:0010980)1.93269828
127Gastrointestinal infarctions (HP:0005244)1.91510268
128Gangrene (HP:0100758)1.90357023
129Arthralgia (HP:0002829)1.90192477
130Abnormal hair whorl (HP:0010721)1.90029871
131Osteomyelitis (HP:0002754)1.88929294
132Meningitis (HP:0001287)1.88700550
133Periodontitis (HP:0000704)1.86361746
134Pathologic fracture (HP:0002756)1.86342602
135Chronic mucocutaneous candidiasis (HP:0002728)1.84398775
136Recurrent cutaneous fungal infections (HP:0011370)1.84398775
137Progressive neurologic deterioration (HP:0002344)1.84201884
138Amyloidosis (HP:0011034)1.83048078
139Inflammation of the large intestine (HP:0002037)1.78706744
140Thoracic kyphosis (HP:0002942)1.78520694
141Episodic fever (HP:0001954)1.78253085
142Diminished motivation (HP:0000745)1.77277107
143Abnormality of the lumbar spine (HP:0100712)1.77173187
144Foot dorsiflexor weakness (HP:0009027)1.76663836
145Steppage gait (HP:0003376)1.75724909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.04492686
2TXK3.19138360
3GRK72.90420637
4BLK2.40348616
5RIPK42.32167658
6MAP3K142.27739377
7TYK22.22699576
8ITK2.21759642
9CSF1R2.15464120
10EPHB12.13670302
11MAP4K12.11156902
12IRAK42.00614208
13MAPKAPK51.85894111
14MAP3K131.83660883
15TBK11.74530261
16BMPR1B1.69892884
17JAK11.69802235
18IKBKE1.68650693
19ZAP701.67826177
20KIT1.63118738
21BMPR21.59272498
22MAP2K31.58474291
23NTRK11.57692630
24TRPM71.54803748
25GRK61.51247881
26LCK1.48310597
27CLK11.47846885
28ACVR1B1.47011807
29STK101.42921337
30IRAK31.37963933
31PRPF4B1.36900135
32FES1.31016297
33MAPK151.28229297
34MARK31.28225346
35HCK1.27934834
36STK391.26971829
37SYK1.24317788
38GRK51.24153384
39PIK3CG1.23884060
40TEC1.21302030
41IKBKB1.20105919
42MYLK1.18944670
43TAOK31.18222017
44ADRBK21.16361663
45BTK1.13607827
46MAP3K121.13142832
47WNK11.12798505
48CSK1.12082993
49YES11.11456175
50FGR1.10498483
51MAP3K21.09911130
52CAMKK21.09051736
53ERN11.05337209
54JAK31.04841561
55MOS1.04299294
56MAP3K31.02880941
57DDR20.98780974
58MAP3K10.94697398
59LYN0.94086639
60NEK90.92490884
61FGFR30.91428949
62TNK20.89060740
63JAK20.88898159
64MATK0.87364069
65PKN10.84692582
66BMX0.83887742
67SIK30.79529139
68MAP4K20.78091179
69TAOK20.77841735
70MAP3K110.77516302
71HIPK20.77295622
72PRKCQ0.76794401
73RET0.76442326
74FGFR40.76410320
75SIK20.75744168
76MINK10.74926387
77CAMK1G0.73300748
78CDK90.72162869
79PIM10.72005702
80PDPK10.71373104
81CAMK1D0.70553885
82CDC42BPA0.69580586
83RIPK10.67150002
84MAPKAPK20.66952023
85MAP3K50.66102468
86FGFR20.65406078
87MAPKAPK30.65258836
88SGK4940.65109372
89SGK2230.65109372
90SGK30.65077835
91MAP3K100.64447823
92PDGFRB0.63627168
93FYN0.63392506
94SGK20.62875697
95ARAF0.62046349
96PIM20.61409861
97MAPK70.60059701
98PDK20.60011224
99CDK30.59563841
100MARK20.58622106
101PDK10.57845035
102EPHA30.56976206
103LMTK20.56885172
104NLK0.56712971
105IGF1R0.53268840
106MAP2K20.53072974
107MAP2K70.53066009
108PTK2B0.52914069
109INSR0.51984100
110IRAK20.51307480
111EGFR0.51095436
112ABL10.50750021
113PRKCD0.49951169
114PHKG10.49778080
115PHKG20.49778080
116MST40.49362272
117TGFBR10.49059560
118KDR0.48857594
119CDK50.48727668
120ADRBK10.48079512
121CAMKK10.46516021
122PRKD10.46347876
123MAPK120.44588887
124CHUK0.42588352
125OXSR10.42497730
126SCYL20.42206759
127PRKCH0.41776663
128KSR20.41627212
129IRAK10.41070220
130CASK0.41062249
131MAP3K60.37403477
132MAPK40.36941471
133DAPK20.36463653
134TESK20.35514730
135CDK60.32244178
136DYRK1B0.28502305
137MAPK110.27601430

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.04892414
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.60510939
3Lysosome_Homo sapiens_hsa041422.49692682
4Primary immunodeficiency_Homo sapiens_hsa053402.23736775
5Other glycan degradation_Homo sapiens_hsa005112.22863163
6Osteoclast differentiation_Homo sapiens_hsa043802.22436474
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21653389
8Leishmaniasis_Homo sapiens_hsa051402.08788309
9Graft-versus-host disease_Homo sapiens_hsa053322.03732686
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02598064
11Pertussis_Homo sapiens_hsa051331.95076047
12B cell receptor signaling pathway_Homo sapiens_hsa046621.87633408
13T cell receptor signaling pathway_Homo sapiens_hsa046601.83638515
14Allograft rejection_Homo sapiens_hsa053301.75410570
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75389792
16Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.74672484
17Malaria_Homo sapiens_hsa051441.64835565
18Rheumatoid arthritis_Homo sapiens_hsa053231.62934055
19Measles_Homo sapiens_hsa051621.61134606
20Tuberculosis_Homo sapiens_hsa051521.60199803
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.58387388
22Salmonella infection_Homo sapiens_hsa051321.53366295
23Antigen processing and presentation_Homo sapiens_hsa046121.49092149
24Hematopoietic cell lineage_Homo sapiens_hsa046401.47643769
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46968051
26Phagosome_Homo sapiens_hsa041451.46814756
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44760646
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42251394
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.39458243
30Chemokine signaling pathway_Homo sapiens_hsa040621.34078135
31Prion diseases_Homo sapiens_hsa050201.29268178
32Ether lipid metabolism_Homo sapiens_hsa005651.29147373
33Toxoplasmosis_Homo sapiens_hsa051451.13871345
34Autoimmune thyroid disease_Homo sapiens_hsa053201.12853243
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10571597
36African trypanosomiasis_Homo sapiens_hsa051431.10141177
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08075515
38Endocytosis_Homo sapiens_hsa041441.07539869
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04446113
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99330547
41Sphingolipid metabolism_Homo sapiens_hsa006000.95615279
42Olfactory transduction_Homo sapiens_hsa047400.95332154
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94376067
44Herpes simplex infection_Homo sapiens_hsa051680.93015363
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.88814238
46Steroid biosynthesis_Homo sapiens_hsa001000.83591739
47Influenza A_Homo sapiens_hsa051640.82197772
48Legionellosis_Homo sapiens_hsa051340.82181499
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79861943
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79804573
51Asthma_Homo sapiens_hsa053100.79693439
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78387338
53ABC transporters_Homo sapiens_hsa020100.77661557
54Apoptosis_Homo sapiens_hsa042100.76951482
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.76739971
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76314120
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.74747713
58Shigellosis_Homo sapiens_hsa051310.74745305
59Viral myocarditis_Homo sapiens_hsa054160.74309779
60Pancreatic cancer_Homo sapiens_hsa052120.73674102
61Hepatitis B_Homo sapiens_hsa051610.71454936
62Complement and coagulation cascades_Homo sapiens_hsa046100.69424332
63Systemic lupus erythematosus_Homo sapiens_hsa053220.69283359
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68892847
65Collecting duct acid secretion_Homo sapiens_hsa049660.66742423
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66370380
67TNF signaling pathway_Homo sapiens_hsa046680.66321745
68Non-homologous end-joining_Homo sapiens_hsa034500.65319238
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65003075
70Platelet activation_Homo sapiens_hsa046110.64186327
71Acute myeloid leukemia_Homo sapiens_hsa052210.63967217
72Renin secretion_Homo sapiens_hsa049240.63145496
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59419283
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59314217
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.58536254
76Arachidonic acid metabolism_Homo sapiens_hsa005900.58358827
77Synaptic vesicle cycle_Homo sapiens_hsa047210.56756355
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55881284
79Hepatitis C_Homo sapiens_hsa051600.55412981
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.52712945
81VEGF signaling pathway_Homo sapiens_hsa043700.51802365
82Dorso-ventral axis formation_Homo sapiens_hsa043200.51416428
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51163175
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50444106
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.50377663
86Chronic myeloid leukemia_Homo sapiens_hsa052200.49616589
87Amoebiasis_Homo sapiens_hsa051460.49191243
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48256848
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47777034
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47710541
91Type I diabetes mellitus_Homo sapiens_hsa049400.46194608
92Salivary secretion_Homo sapiens_hsa049700.45456909
93Cholinergic synapse_Homo sapiens_hsa047250.45413750
94Glycerolipid metabolism_Homo sapiens_hsa005610.45119673
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44579922
96MAPK signaling pathway_Homo sapiens_hsa040100.44040879
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43590478
98Ras signaling pathway_Homo sapiens_hsa040140.43173990
99Mineral absorption_Homo sapiens_hsa049780.43112230
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41287908
101Prolactin signaling pathway_Homo sapiens_hsa049170.41284857
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41027117
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39251041
104Choline metabolism in cancer_Homo sapiens_hsa052310.37794491
105Renin-angiotensin system_Homo sapiens_hsa046140.37382379
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.36371644
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36180749
108GnRH signaling pathway_Homo sapiens_hsa049120.35805943
109HTLV-I infection_Homo sapiens_hsa051660.32192833
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.30681763
111Rap1 signaling pathway_Homo sapiens_hsa040150.29664667
112PPAR signaling pathway_Homo sapiens_hsa033200.29475245
113Non-small cell lung cancer_Homo sapiens_hsa052230.28921599
114Regulation of autophagy_Homo sapiens_hsa041400.27587717
115Epstein-Barr virus infection_Homo sapiens_hsa051690.27360583
116Pancreatic secretion_Homo sapiens_hsa049720.25145038
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23513424
118Oxytocin signaling pathway_Homo sapiens_hsa049210.22858756

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