SLC9B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.89761250
2piRNA metabolic process (GO:0034587)8.41457192
3fusion of sperm to egg plasma membrane (GO:0007342)7.48826656
4multicellular organism reproduction (GO:0032504)7.08628824
5axonemal dynein complex assembly (GO:0070286)7.00733215
6sperm-egg recognition (GO:0035036)6.91495186
7sperm motility (GO:0030317)6.84684987
8male meiosis (GO:0007140)6.78380943
9binding of sperm to zona pellucida (GO:0007339)6.49348549
10acrosome assembly (GO:0001675)6.23052674
11motile cilium assembly (GO:0044458)6.13550211
12cell-cell recognition (GO:0009988)6.12277640
13synaptonemal complex assembly (GO:0007130)6.00114869
14DNA methylation involved in gamete generation (GO:0043046)6.00070013
15epithelial cilium movement (GO:0003351)5.96820701
16synaptonemal complex organization (GO:0070193)5.92669739
17behavioral response to nicotine (GO:0035095)5.87168779
18cell wall macromolecule metabolic process (GO:0044036)5.82859200
19cell wall macromolecule catabolic process (GO:0016998)5.82859200
20spermatid development (GO:0007286)5.71066557
21acrosome reaction (GO:0007340)5.63382944
22plasma membrane fusion (GO:0045026)5.56207602
23reproduction (GO:0000003)5.55178032
24L-fucose catabolic process (GO:0042355)5.31049569
25fucose catabolic process (GO:0019317)5.31049569
26L-fucose metabolic process (GO:0042354)5.31049569
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.29462365
28cilium movement (GO:0003341)5.22373261
29microtubule depolymerization (GO:0007019)5.13736281
30chromosome organization involved in meiosis (GO:0070192)4.83797939
31male meiosis I (GO:0007141)4.83391941
32regulation of cilium movement (GO:0003352)4.79429669
33meiotic cell cycle (GO:0051321)4.72328120
34single fertilization (GO:0007338)4.70708880
35meiotic nuclear division (GO:0007126)4.56660054
36fertilization (GO:0009566)4.26562532
37meiosis I (GO:0007127)4.12488873
38spermatogenesis (GO:0007283)4.09605176
39male gamete generation (GO:0048232)4.09337009
40platelet dense granule organization (GO:0060155)4.05893038
41protein K6-linked ubiquitination (GO:0085020)4.00906357
42regulation of centriole replication (GO:0046599)3.96922538
43nuclear pore complex assembly (GO:0051292)3.94565062
44gamete generation (GO:0007276)3.87156915
45regulation of meiosis I (GO:0060631)3.83460588
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.83102573
47meiotic cell cycle process (GO:1903046)3.76426646
48nuclear pore organization (GO:0006999)3.76102781
49DNA deamination (GO:0045006)3.71537681
50monoubiquitinated protein deubiquitination (GO:0035520)3.69089843
51mitotic metaphase plate congression (GO:0007080)3.67927850
52centriole assembly (GO:0098534)3.66507569
53histone exchange (GO:0043486)3.65590736
54germ cell development (GO:0007281)3.64684138
55sperm capacitation (GO:0048240)3.63213956
56meiotic chromosome segregation (GO:0045132)3.62193200
57water-soluble vitamin biosynthetic process (GO:0042364)3.61749842
58cellular ketone body metabolic process (GO:0046950)3.55415851
59gene silencing by RNA (GO:0031047)3.52323003
60centriole replication (GO:0007099)3.50612480
61regulation of spindle checkpoint (GO:0090231)3.47924373
62cellular process involved in reproduction in multicellular organism (GO:0022412)3.46792149
63protein polyglutamylation (GO:0018095)3.45832430
64response to pheromone (GO:0019236)3.43528458
65sister chromatid cohesion (GO:0007062)3.38381195
66pore complex assembly (GO:0046931)3.35235751
67indole-containing compound catabolic process (GO:0042436)3.35209958
68indolalkylamine catabolic process (GO:0046218)3.35209958
69tryptophan catabolic process (GO:0006569)3.35209958
70protein localization to chromosome, centromeric region (GO:0071459)3.34803427
71kinetochore organization (GO:0051383)3.33741770
72reciprocal DNA recombination (GO:0035825)3.31180732
73reciprocal meiotic recombination (GO:0007131)3.31180732
74chromatin remodeling at centromere (GO:0031055)3.30176665
75indolalkylamine metabolic process (GO:0006586)3.26483062
76DNA replication-dependent nucleosome assembly (GO:0006335)3.25750944
77DNA replication-dependent nucleosome organization (GO:0034723)3.25750944
78mitotic sister chromatid cohesion (GO:0007064)3.25145721
79synapsis (GO:0007129)3.25063913
80detection of light stimulus involved in sensory perception (GO:0050962)3.25020796
81detection of light stimulus involved in visual perception (GO:0050908)3.25020796
82ketone body metabolic process (GO:1902224)3.22674767
83axoneme assembly (GO:0035082)3.22157420
84kinetochore assembly (GO:0051382)3.20889955
85microtubule severing (GO:0051013)3.20737554
86rRNA catabolic process (GO:0016075)3.18724412
87DNA packaging (GO:0006323)3.17364446
88DNA methylation (GO:0006306)3.17181568
89DNA alkylation (GO:0006305)3.17181568
90metaphase plate congression (GO:0051310)3.14346421
91cornea development in camera-type eye (GO:0061303)3.13791213
92kynurenine metabolic process (GO:0070189)3.13405612
93seminiferous tubule development (GO:0072520)3.11990077
94negative regulation of telomere maintenance (GO:0032205)3.11658812
95protein complex biogenesis (GO:0070271)3.11635125
96protein-cofactor linkage (GO:0018065)3.11372680
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11094432
98mitochondrial respiratory chain complex I assembly (GO:0032981)3.11094432
99NADH dehydrogenase complex assembly (GO:0010257)3.11094432
100regulation of hexokinase activity (GO:1903299)3.10112426
101regulation of glucokinase activity (GO:0033131)3.10112426
102tryptophan metabolic process (GO:0006568)3.07265885
103CENP-A containing nucleosome assembly (GO:0034080)3.06663308
104mitotic sister chromatid segregation (GO:0000070)3.06127941
105establishment of chromosome localization (GO:0051303)3.04208568
106negative regulation of meiosis (GO:0045835)3.01735158
107intra-S DNA damage checkpoint (GO:0031573)3.01164633
108protein prenylation (GO:0018342)3.00709960
109prenylation (GO:0097354)3.00709960
110chromosome condensation (GO:0030261)3.00599173
111regulation of centrosome cycle (GO:0046605)3.00223753
112single strand break repair (GO:0000012)2.99114074
113photoreceptor cell maintenance (GO:0045494)2.98178683
114synaptic transmission, cholinergic (GO:0007271)2.98008342
115multicellular organismal reproductive process (GO:0048609)2.97020124
116protein K11-linked deubiquitination (GO:0035871)2.96925196
117maturation of 5.8S rRNA (GO:0000460)2.96324850
118auditory receptor cell stereocilium organization (GO:0060088)2.95660687
119nonmotile primary cilium assembly (GO:0035058)2.94747815
120attachment of spindle microtubules to kinetochore (GO:0008608)2.94361957
121ventricular system development (GO:0021591)2.94138801
122replicative senescence (GO:0090399)2.93321646
123respiratory chain complex IV assembly (GO:0008535)2.92349216
124neuronal action potential (GO:0019228)2.92332011
125kidney morphogenesis (GO:0060993)2.91380444
126inner ear receptor stereocilium organization (GO:0060122)2.87738913
127preassembly of GPI anchor in ER membrane (GO:0016254)2.86200634
128DNA replication-independent nucleosome assembly (GO:0006336)2.86096533
129DNA replication-independent nucleosome organization (GO:0034724)2.86096533
130positive regulation of oligodendrocyte differentiation (GO:0048714)2.83628553
131positive regulation of mitotic sister chromatid separation (GO:1901970)2.82849360
132positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82849360
133positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82849360
134microtubule polymerization or depolymerization (GO:0031109)2.81747900
135mismatch repair (GO:0006298)2.81287392
136S-adenosylmethionine metabolic process (GO:0046500)2.81019849
137regulation of nuclear cell cycle DNA replication (GO:0033262)2.78338281
138negative regulation of transcription regulatory region DNA binding (GO:2000678)2.78203723
139intraciliary transport (GO:0042073)2.77766488
140mitochondrial respiratory chain complex assembly (GO:0033108)2.77254719
141nephron tubule morphogenesis (GO:0072078)2.77153750
142nephron epithelium morphogenesis (GO:0072088)2.77153750
143chromosome organization (GO:0051276)2.76488523
144cilium morphogenesis (GO:0060271)2.75919050
145regulation of chromosome segregation (GO:0051983)2.75673577
146regulation of histone H3-K9 methylation (GO:0051570)2.75472368
147primary amino compound metabolic process (GO:1901160)2.74738838
148cellular response to ATP (GO:0071318)2.74274466
149indole-containing compound metabolic process (GO:0042430)2.73613536
150adaptation of signaling pathway (GO:0023058)2.73408512
151behavioral response to ethanol (GO:0048149)2.73159026
152regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.73020361
153regulation of mitotic spindle checkpoint (GO:1903504)2.73020361
154reflex (GO:0060004)2.70842008
155phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70424580
156sulfation (GO:0051923)2.69114289
157mitotic nuclear envelope disassembly (GO:0007077)2.68847878
158DNA replication checkpoint (GO:0000076)2.68845566
159glycerophospholipid catabolic process (GO:0046475)2.65173007
160negative regulation of mast cell activation (GO:0033004)2.64194309
161mannosylation (GO:0097502)2.62622746
162positive regulation of meiosis (GO:0045836)2.60250828
163serotonin metabolic process (GO:0042428)2.57006513
164fucosylation (GO:0036065)2.55731465
165cilium organization (GO:0044782)2.53922608
166cytochrome complex assembly (GO:0017004)2.52610383
167photoreceptor cell development (GO:0042461)2.52516633
168GPI anchor metabolic process (GO:0006505)2.52246425
169positive regulation of fatty acid transport (GO:2000193)2.50943236
170recombinational repair (GO:0000725)2.50760019
171negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50389428
172double-strand break repair via homologous recombination (GO:0000724)2.49208344
173positive regulation of meiotic cell cycle (GO:0051446)2.48938826
174adenosine metabolic process (GO:0046085)2.48185639
175signal peptide processing (GO:0006465)2.47910558
176retinal cone cell development (GO:0046549)2.46638657
177RNA destabilization (GO:0050779)2.44391744
178positive regulation of prostaglandin secretion (GO:0032308)2.43950994
179neural tube formation (GO:0001841)2.43910286
180regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.42742038
181cilium assembly (GO:0042384)2.42008823
182regulation of action potential (GO:0098900)2.40458578
183dopamine transport (GO:0015872)2.39582766
184RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.37356798
185G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37336403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.25882296
2E2F7_22180533_ChIP-Seq_HELA_Human5.57730103
3ZNF274_21170338_ChIP-Seq_K562_Hela3.80544708
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.79690753
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.09028880
6GBX2_23144817_ChIP-Seq_PC3_Human2.88674853
7IGF1R_20145208_ChIP-Seq_DFB_Human2.81306370
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78303967
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74531041
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.72028134
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71007442
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.68776719
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50076170
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46035753
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.45560690
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.42203481
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30967804
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21517481
19EWS_26573619_Chip-Seq_HEK293_Human2.18849190
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.14700101
21P300_19829295_ChIP-Seq_ESCs_Human2.08636418
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94591593
23ER_23166858_ChIP-Seq_MCF-7_Human1.88888467
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82311750
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.77108209
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.76769730
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71862200
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71716043
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70346334
30TAF15_26573619_Chip-Seq_HEK293_Human1.69432641
31CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.68067147
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67481517
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64986644
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64617473
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63782156
36TP53_22573176_ChIP-Seq_HFKS_Human1.61215177
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59087763
38BCAT_22108803_ChIP-Seq_LS180_Human1.56608996
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55061833
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51153846
41STAT3_23295773_ChIP-Seq_U87_Human1.48069201
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47782327
43CBP_20019798_ChIP-Seq_JUKART_Human1.47782327
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47614818
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.47165939
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.45922309
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.45902533
48AR_25329375_ChIP-Seq_VCAP_Human1.44580072
49SMAD4_21799915_ChIP-Seq_A2780_Human1.44229747
50MYC_18940864_ChIP-ChIP_HL60_Human1.43012642
51EZH2_22144423_ChIP-Seq_EOC_Human1.42839426
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42776357
53SOX2_19829295_ChIP-Seq_ESCs_Human1.40558720
54NANOG_19829295_ChIP-Seq_ESCs_Human1.40558720
55TCF4_23295773_ChIP-Seq_U87_Human1.40289954
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39428481
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38421635
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35018325
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.35018325
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34902095
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33237547
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32151660
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.32029447
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31967986
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31945996
66VDR_22108803_ChIP-Seq_LS180_Human1.29873249
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29654150
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.29493940
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29154857
70TCF4_22108803_ChIP-Seq_LS180_Human1.28618675
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28189035
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27006631
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27006631
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.26804890
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24953826
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24621040
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24506864
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23703911
79STAT1_17558387_ChIP-Seq_HELA_Human1.23577653
80ELK1_19687146_ChIP-ChIP_HELA_Human1.23495795
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23264429
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23206805
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22742109
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.21408641
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.21361897
86RUNX2_22187159_ChIP-Seq_PCA_Human1.20743471
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20506464
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.20365487
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20046380
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19961319
91VDR_23849224_ChIP-Seq_CD4+_Human1.19918904
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19341390
93AR_20517297_ChIP-Seq_VCAP_Human1.18006437
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.15927554
95NCOR_22424771_ChIP-Seq_293T_Human1.15686300
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.15536687
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.15369543
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.15202577
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.14907412
100MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14021988
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.14004374
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.13338104
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12463323
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10987743
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10507860
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08915462
107CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08152661
108AR_21909140_ChIP-Seq_LNCAP_Human1.07929747
109HTT_18923047_ChIP-ChIP_STHdh_Human1.07623828
110SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07554080
111HOXB7_26014856_ChIP-Seq_BT474_Human1.07231178
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07023589
113AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06560919
114ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06250180
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.06018704
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05968491
117REST_21632747_ChIP-Seq_MESCs_Mouse1.05433318
118FOXP3_21729870_ChIP-Seq_TREG_Human1.05172691
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05028556
120KLF4_18555785_Chip-Seq_ESCs_Mouse1.04765866
121ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04271445
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04179244
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.04096727
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03697961
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.03356085
126EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01760036
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01273413
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01119592
129ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00755353
130FOXH1_21741376_ChIP-Seq_EPCs_Human1.00659645
131GATA3_21867929_ChIP-Seq_CD8_Mouse0.99815648
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99707295
133P300_18555785_Chip-Seq_ESCs_Mouse0.99123357
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.98974889
135ZFX_18555785_Chip-Seq_ESCs_Mouse0.98182142
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98127163
137SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.96990685
138P53_22387025_ChIP-Seq_ESCs_Mouse0.96808886
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96666257
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96595774
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96595318
142SRF_21415370_ChIP-Seq_HL-1_Mouse0.96405842
143ETS1_20019798_ChIP-Seq_JURKAT_Human0.96214518
144NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95814078
145RNF2_27304074_Chip-Seq_NSC_Mouse0.95269771
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95221867
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95215431
148ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95118932
149GATA3_21867929_ChIP-Seq_TH1_Mouse0.95111569
150CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95052171
151TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94604599
152NMYC_18555785_Chip-Seq_ESCs_Mouse0.94596765
153E2F1_18555785_Chip-Seq_ESCs_Mouse0.94541809
154RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94020313
155FUS_26573619_Chip-Seq_HEK293_Human0.93819891
156IRF8_21731497_ChIP-ChIP_J774_Mouse0.92560918
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92197773
158GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90414987
159STAT3_18555785_ChIP-Seq_MESCs_Mouse0.90109807
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89239528
161CMYC_18555785_Chip-Seq_ESCs_Mouse0.88768897
162NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88082565
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88039655
164IRF1_19129219_ChIP-ChIP_H3396_Human0.87266497
165SOX2_18555785_Chip-Seq_ESCs_Mouse0.86507664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.01013071
2MP0008877_abnormal_DNA_methylation4.96394087
3MP0001929_abnormal_gametogenesis4.01507782
4MP0010094_abnormal_chromosome_stability3.95122631
5MP0008057_abnormal_DNA_replication3.90014415
6MP0003698_abnormal_male_reproductive3.78623322
7MP0003693_abnormal_embryo_hatching3.70462542
8MP0008058_abnormal_DNA_repair3.49780520
9MP0003111_abnormal_nucleus_morphology3.45851592
10MP0002210_abnormal_sex_determination3.33183305
11MP0003195_calcinosis3.02533797
12MP0000372_irregular_coat_pigmentation2.90849914
13MP0002653_abnormal_ependyma_morphology2.89894644
14MP0001145_abnormal_male_reproductive2.66947093
15MP0000569_abnormal_digit_pigmentation2.66339421
16MP0003077_abnormal_cell_cycle2.66311214
17MP0005551_abnormal_eye_electrophysiolog2.64368706
18MP0006072_abnormal_retinal_apoptosis2.57372521
19MP0008007_abnormal_cellular_replicative2.47504616
20MP0000653_abnormal_sex_gland2.45565662
21MP0006292_abnormal_olfactory_placode2.45465597
22MP0002837_dystrophic_cardiac_calcinosis2.38640438
23MP0004957_abnormal_blastocyst_morpholog2.23644524
24MP0002161_abnormal_fertility/fecundity2.21862785
25MP0003718_maternal_effect2.12374016
26MP0003786_premature_aging2.03442734
27MP0005253_abnormal_eye_physiology2.02871872
28MP0004885_abnormal_endolymph1.99788570
29MP0002160_abnormal_reproductive_system1.99480100
30MP0002938_white_spotting1.94217038
31MP0002102_abnormal_ear_morphology1.92459638
32MP0001968_abnormal_touch/_nociception1.90395756
33MP0004043_abnormal_pH_regulation1.88130691
34MP0005084_abnormal_gallbladder_morpholo1.87222131
35MP0003136_yellow_coat_color1.84728746
36MP0009046_muscle_twitch1.78678042
37MP0004147_increased_porphyrin_level1.77958139
38MP0005645_abnormal_hypothalamus_physiol1.72737738
39MP0008932_abnormal_embryonic_tissue1.71688958
40MP0008875_abnormal_xenobiotic_pharmacok1.68273288
41MP0008872_abnormal_physiological_respon1.67959512
42MP0009745_abnormal_behavioral_response1.65900608
43MP0003880_abnormal_central_pattern1.62165896
44MP0000427_abnormal_hair_cycle1.58732842
45MP0002736_abnormal_nociception_after1.58290886
46MP0004142_abnormal_muscle_tone1.57375403
47MP0001501_abnormal_sleep_pattern1.56040413
48MP0008995_early_reproductive_senescence1.51447764
49MP0002272_abnormal_nervous_system1.50492857
50MP0001485_abnormal_pinna_reflex1.50171912
51MP0001119_abnormal_female_reproductive1.46205729
52MP0003787_abnormal_imprinting1.44822252
53MP0002095_abnormal_skin_pigmentation1.43801458
54MP0006276_abnormal_autonomic_nervous1.43200448
55MP0005670_abnormal_white_adipose1.42253161
56MP0000631_abnormal_neuroendocrine_gland1.42100266
57MP0010386_abnormal_urinary_bladder1.41911607
58MP0001486_abnormal_startle_reflex1.41367690
59MP0002876_abnormal_thyroid_physiology1.40442739
60MP0005389_reproductive_system_phenotype1.40076698
61MP0003941_abnormal_skin_development1.38966521
62MP0002928_abnormal_bile_duct1.35649379
63MP0003011_delayed_dark_adaptation1.34399139
64MP0002254_reproductive_system_inflammat1.33931411
65MP0010307_abnormal_tumor_latency1.31004803
66MP0001529_abnormal_vocalization1.25329716
67MP0003646_muscle_fatigue1.20390646
68MP0005171_absent_coat_pigmentation1.17722730
69MP0005423_abnormal_somatic_nervous1.15665848
70MP0000566_synostosis1.15161750
71MP0003283_abnormal_digestive_organ1.14047123
72MP0002557_abnormal_social/conspecific_i1.14023142
73MP0002735_abnormal_chemical_nociception1.12150884
74MP0001986_abnormal_taste_sensitivity1.10558399
75MP0003890_abnormal_embryonic-extraembry1.08659990
76MP0002572_abnormal_emotion/affect_behav1.07614868
77MP0005451_abnormal_body_composition1.07005242
78MP0002132_abnormal_respiratory_system1.06840836
79MP0001324_abnormal_eye_pigmentation1.05878247
80MP0001970_abnormal_pain_threshold1.05752381
81MP0000350_abnormal_cell_proliferation1.05076825
82MP0002064_seizures1.04805575
83MP0004742_abnormal_vestibular_system1.03349904
84MP0000313_abnormal_cell_death1.03251657
85MP0000015_abnormal_ear_pigmentation1.01695323
86MP0005365_abnormal_bile_salt1.00942441
87MP0005647_abnormal_sex_gland1.00738011
88MP0002733_abnormal_thermal_nociception1.00420831
89MP0001730_embryonic_growth_arrest1.00148969
90MP0005195_abnormal_posterior_eye0.98645948
91MP0001293_anophthalmia0.98310230
92MP0002234_abnormal_pharynx_morphology0.97957071
93MP0001672_abnormal_embryogenesis/_devel0.97078300
94MP0005380_embryogenesis_phenotype0.97078300
95MP0003699_abnormal_female_reproductive0.96967837
96MP0001905_abnormal_dopamine_level0.96291825
97MP0002693_abnormal_pancreas_physiology0.95867939
98MP0003806_abnormal_nucleotide_metabolis0.95142195
99MP0001764_abnormal_homeostasis0.93596889
100MP0009697_abnormal_copulation0.93517514
101MP0008775_abnormal_heart_ventricle0.92491505
102MP0000383_abnormal_hair_follicle0.92184856
103MP0004133_heterotaxia0.91970252
104MP0003121_genomic_imprinting0.91942806
105MP0002277_abnormal_respiratory_mucosa0.91688204
106MP0005671_abnormal_response_to0.91343049
107MP0004924_abnormal_behavior0.90581870
108MP0005386_behavior/neurological_phenoty0.90581870
109MP0002090_abnormal_vision0.90388220
110MP0002067_abnormal_sensory_capabilities0.89949781
111MP0005332_abnormal_amino_acid0.89200292
112MP0002229_neurodegeneration0.87511344
113MP0001188_hyperpigmentation0.85500864
114MP0002085_abnormal_embryonic_tissue0.85261961
115MP0003137_abnormal_impulse_conducting0.82731986
116MP0001697_abnormal_embryo_size0.82714977
117MP0005623_abnormal_meninges_morphology0.82437927
118MP0001756_abnormal_urination0.82366086
119MP0005075_abnormal_melanosome_morpholog0.82082077
120MP0002163_abnormal_gland_morphology0.80761397
121MP0003123_paternal_imprinting0.80649751
122MP0000026_abnormal_inner_ear0.80407407
123MP0002084_abnormal_developmental_patter0.80101145
124MP0002752_abnormal_somatic_nervous0.79499691
125MP0001963_abnormal_hearing_physiology0.78265684
126MP0000490_abnormal_crypts_of0.77686548
127MP0000230_abnormal_systemic_arterial0.77575154
128MP0004215_abnormal_myocardial_fiber0.75853528
129MP0001835_abnormal_antigen_presentation0.75831271
130MP0010329_abnormal_lipoprotein_level0.75450941
131MP0002751_abnormal_autonomic_nervous0.75325671
132MP0005395_other_phenotype0.74988831
133MP0005379_endocrine/exocrine_gland_phen0.74178800
134MP0005646_abnormal_pituitary_gland0.73921332
135MP0002019_abnormal_tumor_incidence0.72391446
136MP0005397_hematopoietic_system_phenotyp0.72138506
137MP0001545_abnormal_hematopoietic_system0.72138506
138MP0003984_embryonic_growth_retardation0.69060789
139MP0001919_abnormal_reproductive_system0.67994077
140MP0002088_abnormal_embryonic_growth/wei0.65373770
141MP0003763_abnormal_thymus_physiology0.64573016
142MP0003315_abnormal_perineum_morphology0.62700485
143MP0008789_abnormal_olfactory_epithelium0.62574739
144MP0001984_abnormal_olfaction0.60476631
145MP0008260_abnormal_autophagy0.60470649
146MP0002086_abnormal_extraembryonic_tissu0.59616006
147MP0005257_abnormal_intraocular_pressure0.58481959
148MP0002396_abnormal_hematopoietic_system0.57867023
149MP0002080_prenatal_lethality0.57778034
150MP0005174_abnormal_tail_pigmentation0.57266490
151MP0004808_abnormal_hematopoietic_stem0.56741286
152MP0003937_abnormal_limbs/digits/tail_de0.56562113
153MP0004782_abnormal_surfactant_physiolog0.56041687
154MP0003936_abnormal_reproductive_system0.54124870
155MP0000432_abnormal_head_morphology0.52076662
156MP0005394_taste/olfaction_phenotype0.51715650
157MP0005499_abnormal_olfactory_system0.51715650
158MP0002282_abnormal_trachea_morphology0.51302840
159MP0003186_abnormal_redox_activity0.50793712
160MP0002638_abnormal_pupillary_reflex0.50157467
161MP0005310_abnormal_salivary_gland0.49776921
162MP0002405_respiratory_system_inflammati0.48253998
163MP0003878_abnormal_ear_physiology0.47972202
164MP0005377_hearing/vestibular/ear_phenot0.47972202
165MP0001853_heart_inflammation0.47841978
166MP0001286_abnormal_eye_development0.47841591
167MP0001186_pigmentation_phenotype0.47159597
168MP0005391_vision/eye_phenotype0.46581969
169MP0002249_abnormal_larynx_morphology0.44050861
170MP0002148_abnormal_hypersensitivity_rea0.43595703
171MP0000703_abnormal_thymus_morphology0.43224707

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.82456259
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.44569323
3Absent/shortened dynein arms (HP:0200106)8.44569323
4Abnormal respiratory motile cilium physiology (HP:0012261)6.71309129
5Abnormal respiratory epithelium morphology (HP:0012253)6.27023580
6Abnormal respiratory motile cilium morphology (HP:0005938)6.27023580
7Abnormal ciliary motility (HP:0012262)5.55514786
8Rhinitis (HP:0012384)5.45654288
9Chromosomal breakage induced by crosslinking agents (HP:0003221)5.14781510
10Chronic bronchitis (HP:0004469)4.93785632
11Chromsome breakage (HP:0040012)4.89024721
12Infertility (HP:0000789)4.15110798
13Congenital stationary night blindness (HP:0007642)3.80146262
14Nephronophthisis (HP:0000090)3.71684889
15Impulsivity (HP:0100710)3.52444714
16Attenuation of retinal blood vessels (HP:0007843)3.45038241
17Nasal polyposis (HP:0100582)3.43133984
18Bronchiectasis (HP:0002110)3.36187335
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.27245070
20Meckel diverticulum (HP:0002245)3.18855279
21Supernumerary spleens (HP:0009799)3.16698297
22Abnormal spermatogenesis (HP:0008669)3.16475545
23Abnormality of the preputium (HP:0100587)3.16159405
24Abnormality of chromosome stability (HP:0003220)3.16142994
25Abnormality of the ileum (HP:0001549)3.07282445
26Type II lissencephaly (HP:0007260)2.98851141
27Abnormality of the renal medulla (HP:0100957)2.97008353
28Ectopic kidney (HP:0000086)2.95037629
29Abolished electroretinogram (ERG) (HP:0000550)2.91934663
30Chronic hepatic failure (HP:0100626)2.86841094
31Polydipsia (HP:0001959)2.85149043
32Abnormal drinking behavior (HP:0030082)2.85149043
33Male infertility (HP:0003251)2.80232033
34Bronchitis (HP:0012387)2.80033758
35Birth length less than 3rd percentile (HP:0003561)2.78695066
36Pendular nystagmus (HP:0012043)2.71427759
37Tubulointerstitial nephritis (HP:0001970)2.66410692
38Nephroblastoma (Wilms tumor) (HP:0002667)2.65775039
39Clubbing of toes (HP:0100760)2.61672965
40Azoospermia (HP:0000027)2.61194101
41Abnormal rod and cone electroretinograms (HP:0008323)2.59060623
42Methylmalonic acidemia (HP:0002912)2.58186255
43Decreased central vision (HP:0007663)2.56738514
44Duplicated collecting system (HP:0000081)2.53142622
45Abnormality of midbrain morphology (HP:0002418)2.51193184
46Molar tooth sign on MRI (HP:0002419)2.51193184
47Abnormality of the nasal mucosa (HP:0000433)2.50132158
48Gonadotropin excess (HP:0000837)2.49582861
49Embryonal renal neoplasm (HP:0011794)2.49480399
50Acute necrotizing encephalopathy (HP:0006965)2.49160034
51Abnormality of alanine metabolism (HP:0010916)2.48463860
52Hyperalaninemia (HP:0003348)2.48463860
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48463860
54Small intestinal stenosis (HP:0012848)2.48109060
55Duodenal stenosis (HP:0100867)2.48109060
56Acute encephalopathy (HP:0006846)2.46361413
57Congenital, generalized hypertrichosis (HP:0004540)2.43254555
58Sloping forehead (HP:0000340)2.43131182
59Hypoplasia of the capital femoral epiphysis (HP:0003090)2.41637999
60Postaxial foot polydactyly (HP:0001830)2.37481804
61Large for gestational age (HP:0001520)2.36732223
62Keratoconus (HP:0000563)2.36302669
63Increased corneal curvature (HP:0100692)2.36302669
64Concave nail (HP:0001598)2.36299683
65Pancreatic fibrosis (HP:0100732)2.35902182
66Polyuria (HP:0000103)2.34138252
67Recurrent sinusitis (HP:0011108)2.32740511
68Mitochondrial inheritance (HP:0001427)2.32170522
69Inability to walk (HP:0002540)2.30974792
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29969078
71Increased CSF lactate (HP:0002490)2.29157764
72Hypothermia (HP:0002045)2.28645936
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.24312330
74Hypoplasia of the fovea (HP:0007750)2.24312330
75Abnormality of the renal collecting system (HP:0004742)2.23982489
7611 pairs of ribs (HP:0000878)2.21852125
77Progressive macrocephaly (HP:0004481)2.20924790
78Abnormality of the carotid arteries (HP:0005344)2.19044925
79Abnormality of the anterior horn cell (HP:0006802)2.18945893
80Degeneration of anterior horn cells (HP:0002398)2.18945893
81Facial cleft (HP:0002006)2.18648308
82Optic disc pallor (HP:0000543)2.16546352
833-Methylglutaconic aciduria (HP:0003535)2.16476551
84Sclerocornea (HP:0000647)2.15404751
85Cerebellar dysplasia (HP:0007033)2.14770705
86Medial flaring of the eyebrow (HP:0010747)2.14752423
87Renal cortical cysts (HP:0000803)2.14027139
88Hypomagnesemia (HP:0002917)2.13350785
89Recurrent otitis media (HP:0000403)2.13096624
90Bony spicule pigmentary retinopathy (HP:0007737)2.13026325
91True hermaphroditism (HP:0010459)2.12719247
92Hyperglycinemia (HP:0002154)2.12108731
93Progressive inability to walk (HP:0002505)2.09939853
94Gait imbalance (HP:0002141)2.08785872
95Abnormal mitochondria in muscle tissue (HP:0008316)2.07740702
96Methylmalonic aciduria (HP:0012120)2.07665544
97Congenital primary aphakia (HP:0007707)2.06961840
98Albinism (HP:0001022)2.04320167
99Bone marrow hypocellularity (HP:0005528)2.03800819
100Furrowed tongue (HP:0000221)2.03241031
101Abnormal number of erythroid precursors (HP:0012131)2.01897729
102Hyperventilation (HP:0002883)2.01698751
103Abnormality of DNA repair (HP:0003254)2.01548759
104Nephrogenic diabetes insipidus (HP:0009806)2.00209371
105Absent thumb (HP:0009777)1.98668529
106Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98644119
107Pancreatic cysts (HP:0001737)1.98488239
108Median cleft lip (HP:0000161)1.97937870
109Congenital hepatic fibrosis (HP:0002612)1.97909658
110Myelodysplasia (HP:0002863)1.97333478
111Congenital sensorineural hearing impairment (HP:0008527)1.97218648
112Stomatitis (HP:0010280)1.96550173
113Lissencephaly (HP:0001339)1.95736255
114Abnormality of the pons (HP:0007361)1.95690782
115Prostate neoplasm (HP:0100787)1.92827580
116Abnormality of the fovea (HP:0000493)1.91374856
117Abnormality of the duodenum (HP:0002246)1.90320258
118Selective tooth agenesis (HP:0001592)1.90110188
119Breast hypoplasia (HP:0003187)1.90088824
120Fibular hypoplasia (HP:0003038)1.89315774
121Hypoplasia of the pons (HP:0012110)1.88813482
122Absent epiphyses (HP:0010577)1.88647484
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88647484
124Hepatocellular necrosis (HP:0001404)1.88357360
125Chorioretinal atrophy (HP:0000533)1.88046787
126Hepatic necrosis (HP:0002605)1.87215409
127Gaze-evoked nystagmus (HP:0000640)1.86874718
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.86458310
129Abnormal urine output (HP:0012590)1.85986644
130Absent radius (HP:0003974)1.85170728
131Hyperglycinuria (HP:0003108)1.84875975
132Abnormal protein N-linked glycosylation (HP:0012347)1.82984291
133Abnormal protein glycosylation (HP:0012346)1.82984291
134Abnormal glycosylation (HP:0012345)1.82984291
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82984291
136Intestinal atresia (HP:0011100)1.82598749
137Anencephaly (HP:0002323)1.82583960
138Renal dysplasia (HP:0000110)1.81235240
139Type I transferrin isoform profile (HP:0003642)1.79569822
140Severe muscular hypotonia (HP:0006829)1.79022209
141Hemiparesis (HP:0001269)1.78415625
142Short thumb (HP:0009778)1.78312902
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78170121
144Tubular atrophy (HP:0000092)1.77761389
145Tachypnea (HP:0002789)1.77355320
146Tubulointerstitial fibrosis (HP:0005576)1.75115622
147Lipid accumulation in hepatocytes (HP:0006561)1.74560840
148Patellar aplasia (HP:0006443)1.74405710
149Thyroiditis (HP:0100646)1.74299996
150Optic neuritis (HP:0100653)1.74076943
151Retrobulbar optic neuritis (HP:0100654)1.74076943
152Abnormality of vitamin B metabolism (HP:0004340)1.73482506
153Absent forearm bone (HP:0003953)1.72746673
154Aplasia involving forearm bones (HP:0009822)1.72746673
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.71373133
156Optic nerve hypoplasia (HP:0000609)1.71215269
157Preaxial hand polydactyly (HP:0001177)1.71011398
158Decreased circulating renin level (HP:0003351)1.70759196
159Abnormality of the renal cortex (HP:0011035)1.70579854
160Increased hepatocellular lipid droplets (HP:0006565)1.70320842
161Triphalangeal thumb (HP:0001199)1.69003312
162Type 2 muscle fiber atrophy (HP:0003554)1.68490513
163Tubulointerstitial abnormality (HP:0001969)1.65178234
164Occipital encephalocele (HP:0002085)1.64452181
165Abdominal situs inversus (HP:0003363)1.64174696
166Abnormality of abdominal situs (HP:0011620)1.64174696
167Bile duct proliferation (HP:0001408)1.63388411
168Abnormal biliary tract physiology (HP:0012439)1.63388411
169Abnormality of the labia minora (HP:0012880)1.61667330
170Impaired proprioception (HP:0010831)1.60566729
171Cystic liver disease (HP:0006706)1.60384407
172Astigmatism (HP:0000483)1.59678126
173Abnormality of permanent molar morphology (HP:0011071)1.59259117
174Abnormality of the dental root (HP:0006486)1.59259117
175Taurodontia (HP:0000679)1.59259117
176Medulloblastoma (HP:0002885)1.59226959
177Abnormal lung lobation (HP:0002101)1.58015842
178Aplasia/Hypoplasia of the patella (HP:0006498)1.56549207
179Male pseudohermaphroditism (HP:0000037)1.56447298
180Papillary thyroid carcinoma (HP:0002895)1.55671668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.55487516
2PDK45.54530416
3PDK35.54530416
4PDK23.69696295
5MAP4K23.26876261
6PLK43.19511646
7WNK33.07801474
8TTK2.77075750
9NEK22.76223112
10CDC72.69662108
11INSRR2.67357335
12WEE12.62289378
13NUAK12.59433726
14TESK12.56366155
15STK38L2.28859841
16PRKD32.11954554
17ZAK2.04446693
18BUB11.96232839
19SRPK11.93903292
20EIF2AK11.89659817
21PNCK1.80863880
22CHEK21.76443661
23PLK11.69495435
24ATR1.66375927
25CCNB11.58083369
26OXSR11.52319097
27MAPK131.49109266
28DAPK21.44877003
29STK391.44091971
30STK161.43879458
31PLK21.42688648
32EPHA21.42675501
33PASK1.39042754
34AKT31.38127935
35BRAF1.38109891
36BMPR1B1.34525267
37STK31.32524295
38BRSK21.32061138
39PAK31.26565481
40DYRK31.26083664
41CDK121.24177040
42CHEK11.22737384
43CAMKK21.20018265
44PINK11.17926529
45ICK1.17667529
46ACVR1B1.17093060
47MKNK21.16044847
48TNIK1.15205166
49CASK1.11744786
50ADRBK11.11364017
51MAP3K41.08664609
52BMPR21.08659482
53MAP3K141.08452658
54TXK1.08343922
55PLK31.07339728
56VRK21.06884522
57CDK71.06418242
58ATM1.03922793
59MST41.03126160
60TRIM281.02228683
61VRK11.01405904
62MARK11.01329202
63EIF2AK20.99985870
64PRKCE0.98717542
65STK380.97392616
66AURKB0.97112377
67YES10.94945849
68MAP3K60.93365197
69GRK10.92230065
70NTRK30.90910613
71PRKCG0.88222608
72BCKDK0.88102927
73PRKCQ0.78292722
74EPHA40.77654919
75TGFBR10.77184927
76CDK30.74826495
77PIM10.74776430
78MKNK10.73723737
79NEK60.71839372
80IRAK30.71255490
81MUSK0.70383871
82CHUK0.67838652
83ERBB40.67738636
84PHKG20.67530275
85PHKG10.67530275
86PIK3CA0.67119054
87AURKA0.65553987
88CSNK1G20.64010748
89TIE10.63443354
90BRSK10.63426909
91PTK2B0.63386504
92LATS10.62995370
93EIF2AK30.59957916
94MAP2K70.57535621
95CDK20.57424176
96STK40.57001201
97TLK10.55209229
98BRD40.54148627
99ERBB30.54075451
100FLT30.53686441
101MAPKAPK30.53548806
102FER0.53168048
103FGFR20.53112474
104CDK80.52050128
105IKBKB0.51271586
106CDK10.51131484
107MAP2K60.49755598
108KIT0.47338378
109BCR0.47217275
110GRK70.46814011
111MAP3K120.46558665
112CSNK1G10.46480829
113IRAK20.46162018
114CSNK2A10.45981735
115ITK0.45071771
116TAOK30.44097755
117PRKG10.43820111
118CSNK1G30.43618030
119CAMK2A0.43355369
120CDK40.43355146
121MAPKAPK50.43304792
122MAP3K50.42900582
123SGK20.42727966
124MAPK150.40711201
125NLK0.40389872
126CSNK1A1L0.40296323
127TAOK20.40257015
128STK110.39635132
129CAMK10.39617110
130PRKACA0.39531935
131TEC0.39395948
132ADRBK20.39181995
133RPS6KB10.38929320
134PRKCI0.38649171
135PKN10.38440213
136MAP2K20.37038230
137DYRK20.36877212
138EPHA30.36033126
139MAP2K10.35332931
140DYRK1A0.35135760
141RPS6KA40.35126418
142PBK0.34646576
143IRAK10.34118208
144RPS6KB20.33937418
145WNK40.33239431
146MAP3K80.32822932
147MELK0.32016506
148IRAK40.31771229
149NEK10.28964266
150CSNK2A20.28656357
151PAK10.27654926
152RPS6KA50.25827347
153LATS20.25322818
154CLK10.24847261
155STK240.23722099
156GSK3B0.22823455
157STK100.22407718
158CSNK1D0.22165744

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.35553668
2Basal transcription factors_Homo sapiens_hsa030223.82873987
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45238995
4Homologous recombination_Homo sapiens_hsa034403.42899927
5DNA replication_Homo sapiens_hsa030303.24097629
6Mismatch repair_Homo sapiens_hsa034303.16010557
7RNA transport_Homo sapiens_hsa030132.94877838
8Vitamin B6 metabolism_Homo sapiens_hsa007502.82240124
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73029350
10Cell cycle_Homo sapiens_hsa041102.63817612
11Base excision repair_Homo sapiens_hsa034102.60473579
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.58231343
13RNA polymerase_Homo sapiens_hsa030202.58070059
14Butanoate metabolism_Homo sapiens_hsa006502.55093088
15Oxidative phosphorylation_Homo sapiens_hsa001902.45768947
16RNA degradation_Homo sapiens_hsa030182.38185159
17Nitrogen metabolism_Homo sapiens_hsa009102.36133673
18Nucleotide excision repair_Homo sapiens_hsa034202.34726662
19Non-homologous end-joining_Homo sapiens_hsa034502.32511675
20Spliceosome_Homo sapiens_hsa030402.26372120
21Pyrimidine metabolism_Homo sapiens_hsa002402.26210642
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22715117
23Protein export_Homo sapiens_hsa030602.17756074
24mRNA surveillance pathway_Homo sapiens_hsa030152.10987780
25Proteasome_Homo sapiens_hsa030502.01502951
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.00008871
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92076101
28p53 signaling pathway_Homo sapiens_hsa041151.86939063
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84353370
30One carbon pool by folate_Homo sapiens_hsa006701.82243102
31Parkinsons disease_Homo sapiens_hsa050121.77858981
32Linoleic acid metabolism_Homo sapiens_hsa005911.75013466
33Purine metabolism_Homo sapiens_hsa002301.73182322
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71249482
35Nicotine addiction_Homo sapiens_hsa050331.68494413
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66190112
37Propanoate metabolism_Homo sapiens_hsa006401.64891794
38Peroxisome_Homo sapiens_hsa041461.60022247
39Tryptophan metabolism_Homo sapiens_hsa003801.54220592
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53198100
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.50924219
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45435124
43Caffeine metabolism_Homo sapiens_hsa002321.40020337
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35151901
45Olfactory transduction_Homo sapiens_hsa047401.31085282
46Herpes simplex infection_Homo sapiens_hsa051681.27404627
47Oocyte meiosis_Homo sapiens_hsa041141.24921125
48Arachidonic acid metabolism_Homo sapiens_hsa005901.23466754
49Cardiac muscle contraction_Homo sapiens_hsa042601.18678186
50Selenocompound metabolism_Homo sapiens_hsa004501.18145720
51Chemical carcinogenesis_Homo sapiens_hsa052041.14053190
52Taste transduction_Homo sapiens_hsa047421.13359107
53Alzheimers disease_Homo sapiens_hsa050101.11772271
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07322514
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06585698
56Epstein-Barr virus infection_Homo sapiens_hsa051691.06470338
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02885462
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02680513
59Ether lipid metabolism_Homo sapiens_hsa005650.99903622
60ABC transporters_Homo sapiens_hsa020100.97582198
61Morphine addiction_Homo sapiens_hsa050320.94738610
62Insulin secretion_Homo sapiens_hsa049110.92591016
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.90905754
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86907653
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86794270
66Pentose phosphate pathway_Homo sapiens_hsa000300.86397984
67Antigen processing and presentation_Homo sapiens_hsa046120.86310019
68Retinol metabolism_Homo sapiens_hsa008300.85887795
69Fatty acid elongation_Homo sapiens_hsa000620.84839651
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.83825102
71Systemic lupus erythematosus_Homo sapiens_hsa053220.82534419
72Serotonergic synapse_Homo sapiens_hsa047260.81156305
73Legionellosis_Homo sapiens_hsa051340.80980026
74Huntingtons disease_Homo sapiens_hsa050160.80311872
75Allograft rejection_Homo sapiens_hsa053300.79704168
76Measles_Homo sapiens_hsa051620.77460489
77Circadian entrainment_Homo sapiens_hsa047130.76309557
78Graft-versus-host disease_Homo sapiens_hsa053320.76241370
79Sulfur metabolism_Homo sapiens_hsa009200.75660790
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74748954
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.74304999
82Influenza A_Homo sapiens_hsa051640.73238596
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72078147
84Autoimmune thyroid disease_Homo sapiens_hsa053200.71853027
85Glutamatergic synapse_Homo sapiens_hsa047240.71255574
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71094205
87Collecting duct acid secretion_Homo sapiens_hsa049660.70559274
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68382591
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.68372246
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64593270
91Fatty acid degradation_Homo sapiens_hsa000710.64390206
92Sulfur relay system_Homo sapiens_hsa041220.64362544
93GABAergic synapse_Homo sapiens_hsa047270.64051373
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.62860133
95Viral carcinogenesis_Homo sapiens_hsa052030.62059927
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60120518
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59939658
98Salivary secretion_Homo sapiens_hsa049700.59799560
99beta-Alanine metabolism_Homo sapiens_hsa004100.59535483
100Other glycan degradation_Homo sapiens_hsa005110.59283326
101Dorso-ventral axis formation_Homo sapiens_hsa043200.59026900
102Fatty acid biosynthesis_Homo sapiens_hsa000610.57703304
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55607029
104Fat digestion and absorption_Homo sapiens_hsa049750.54187530
105Fatty acid metabolism_Homo sapiens_hsa012120.54043100
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52577448
107Asthma_Homo sapiens_hsa053100.52397383
108Calcium signaling pathway_Homo sapiens_hsa040200.51960371
109Fructose and mannose metabolism_Homo sapiens_hsa000510.51504531
110HTLV-I infection_Homo sapiens_hsa051660.50259601
111Glycerolipid metabolism_Homo sapiens_hsa005610.50226018
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48793322
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.47699980
114Glutathione metabolism_Homo sapiens_hsa004800.44478340
115Pyruvate metabolism_Homo sapiens_hsa006200.43783591
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42858951
117Regulation of autophagy_Homo sapiens_hsa041400.41105981
118Glucagon signaling pathway_Homo sapiens_hsa049220.39565286
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39077768
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37993828
121Histidine metabolism_Homo sapiens_hsa003400.37909888
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37647180
123Sphingolipid metabolism_Homo sapiens_hsa006000.36531035
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36131508
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.35944932
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35901258
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35535284
128Long-term depression_Homo sapiens_hsa047300.35449657
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34832360
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32455277
131Primary immunodeficiency_Homo sapiens_hsa053400.31912687
132Type I diabetes mellitus_Homo sapiens_hsa049400.29521773
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.28488731
134TGF-beta signaling pathway_Homo sapiens_hsa043500.28245080
135Small cell lung cancer_Homo sapiens_hsa052220.28224115
136Hematopoietic cell lineage_Homo sapiens_hsa046400.27440145
137Ovarian steroidogenesis_Homo sapiens_hsa049130.26343625
138Mineral absorption_Homo sapiens_hsa049780.26264009
139Apoptosis_Homo sapiens_hsa042100.26094399
140Hedgehog signaling pathway_Homo sapiens_hsa043400.25930298
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24870600
142Metabolic pathways_Homo sapiens_hsa011000.23500623
143Wnt signaling pathway_Homo sapiens_hsa043100.23462182
144Phototransduction_Homo sapiens_hsa047440.22139285
145MicroRNAs in cancer_Homo sapiens_hsa052060.21154284
146Basal cell carcinoma_Homo sapiens_hsa052170.20976142
147Inositol phosphate metabolism_Homo sapiens_hsa005620.20420863
148Circadian rhythm_Homo sapiens_hsa047100.20031477
149TNF signaling pathway_Homo sapiens_hsa046680.19630988
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18876681
151Ribosome_Homo sapiens_hsa030100.18376687
152Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17661908
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17550266
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17344191
155Hippo signaling pathway_Homo sapiens_hsa043900.16859236
156Notch signaling pathway_Homo sapiens_hsa043300.14938209
157Rheumatoid arthritis_Homo sapiens_hsa053230.14032520
158Vitamin digestion and absorption_Homo sapiens_hsa049770.12690636

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »