SLC9B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)8.02739828
2response to pheromone (GO:0019236)7.00405577
3detection of molecule of bacterial origin (GO:0032490)5.95243023
4negative regulation of fibrinolysis (GO:0051918)5.37596402
5regulation of fibrinolysis (GO:0051917)5.17043312
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.87576332
7auditory receptor cell stereocilium organization (GO:0060088)4.69564742
8sulfate transmembrane transport (GO:1902358)4.66224074
9synaptic vesicle maturation (GO:0016188)4.63157644
10glutamate secretion (GO:0014047)4.56851855
11cellular anion homeostasis (GO:0030002)4.55717992
12energy homeostasis (GO:0097009)4.44231572
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.41512724
14positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.26738102
15L-phenylalanine catabolic process (GO:0006559)4.23116845
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.23116845
17G-protein coupled receptor internalization (GO:0002031)4.22088304
18regulation of protein activation cascade (GO:2000257)4.07501366
19sulfate transport (GO:0008272)4.03372895
20detection of external biotic stimulus (GO:0098581)3.99318187
21positive regulation of heat generation (GO:0031652)3.95227378
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90545000
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.89783798
24L-phenylalanine metabolic process (GO:0006558)3.89783798
25exogenous drug catabolic process (GO:0042738)3.87987482
26positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.84316373
27regulation of complement activation (GO:0030449)3.82304507
28neurotransmitter secretion (GO:0007269)3.81708870
29regulation of fever generation (GO:0031620)3.78988946
30intestinal cholesterol absorption (GO:0030299)3.76885402
31inner ear receptor stereocilium organization (GO:0060122)3.70477868
32drug catabolic process (GO:0042737)3.66730800
33protein carboxylation (GO:0018214)3.64160562
34peptidyl-glutamic acid carboxylation (GO:0017187)3.64160562
35regulation of plasminogen activation (GO:0010755)3.62904845
36phosphate ion homeostasis (GO:0055062)3.61079663
37trivalent inorganic anion homeostasis (GO:0072506)3.61079663
38complement activation, alternative pathway (GO:0006957)3.58312483
39synaptic vesicle exocytosis (GO:0016079)3.55295286
40detection of biotic stimulus (GO:0009595)3.54848892
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.53174611
42positive regulation of uterine smooth muscle contraction (GO:0070474)3.53137542
43positive regulation of transforming growth factor beta production (GO:0071636)3.50439370
44fibrinolysis (GO:0042730)3.34259030
45neurotransmitter-gated ion channel clustering (GO:0072578)3.32332219
46dicarboxylic acid biosynthetic process (GO:0043650)3.30784717
47regulation of synaptic vesicle exocytosis (GO:2000300)3.30520209
48positive regulation of prostaglandin secretion (GO:0032308)3.30327726
49blood coagulation, intrinsic pathway (GO:0007597)3.29964857
50mesenchymal cell differentiation involved in kidney development (GO:0072161)3.29271161
51mesenchymal cell differentiation involved in renal system development (GO:2001012)3.29271161
52post-embryonic morphogenesis (GO:0009886)3.28871315
53lateral ventricle development (GO:0021670)3.27535377
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.23782598
55prostate gland growth (GO:0060736)3.22721234
56negative regulation of macroautophagy (GO:0016242)3.22025281
57omega-hydroxylase P450 pathway (GO:0097267)3.20947468
58glutamate metabolic process (GO:0006536)3.18663242
59ionotropic glutamate receptor signaling pathway (GO:0035235)3.18268236
60urea metabolic process (GO:0019627)3.17949292
61negative regulation of cholesterol transport (GO:0032375)3.17530482
62negative regulation of sterol transport (GO:0032372)3.17530482
63positive regulation of icosanoid secretion (GO:0032305)3.17463928
64response to parathyroid hormone (GO:0071107)3.16311077
65cellular potassium ion homeostasis (GO:0030007)3.15308417
66regulation of non-canonical Wnt signaling pathway (GO:2000050)3.14539192
67aromatic amino acid family catabolic process (GO:0009074)3.11628344
68positive regulation of cellular amide metabolic process (GO:0034250)3.09577452
69negative regulation of mast cell activation (GO:0033004)3.07958113
70C4-dicarboxylate transport (GO:0015740)3.05869116
71positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05475482
72gamma-aminobutyric acid transport (GO:0015812)3.05255607
73regulation of vesicle fusion (GO:0031338)3.04257545
74nitrogen cycle metabolic process (GO:0071941)3.04096431
75regulation of heat generation (GO:0031650)3.03940160
76neuron remodeling (GO:0016322)3.02130977
77cholesterol efflux (GO:0033344)2.99687235
78glyoxylate metabolic process (GO:0046487)2.98748780
79drinking behavior (GO:0042756)2.96908393
80neuronal action potential propagation (GO:0019227)2.96259802
81regulation of interleukin-6 biosynthetic process (GO:0045408)2.94902216
82regulation of cholesterol esterification (GO:0010872)2.94060850
83regulation of neuronal synaptic plasticity (GO:0048168)2.92729045
84histone H3-K9 modification (GO:0061647)2.92171672
85regulation of activation of Janus kinase activity (GO:0010533)2.91772170
86acute-phase response (GO:0006953)2.90614496
87synaptic transmission, glutamatergic (GO:0035249)2.89565196
88low-density lipoprotein particle remodeling (GO:0034374)2.89406665
89opioid receptor signaling pathway (GO:0038003)2.89222163
90epoxygenase P450 pathway (GO:0019373)2.89066688
91regulation of synaptic vesicle transport (GO:1902803)2.89043245
92negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87371862
93positive regulation of hemostasis (GO:1900048)2.86869569
94positive regulation of blood coagulation (GO:0030194)2.86869569
95positive regulation of dendritic spine development (GO:0060999)2.85654734
96negative regulation of protein activation cascade (GO:2000258)2.85404334
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84576232
98bile acid biosynthetic process (GO:0006699)2.83841611
99negative regulation of T cell mediated immunity (GO:0002710)2.83166422
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82815877
101regulation of mitotic spindle checkpoint (GO:1903504)2.82815877
102negative regulation of translation, ncRNA-mediated (GO:0040033)2.82409172
103regulation of translation, ncRNA-mediated (GO:0045974)2.82409172
104negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82409172
105developmental pigmentation (GO:0048066)2.81399349
106oxidative demethylation (GO:0070989)2.81057867
107embryonic camera-type eye morphogenesis (GO:0048596)2.80732096
108positive regulation of CREB transcription factor activity (GO:0032793)2.80156140
109regulation of pigment cell differentiation (GO:0050932)2.78762293
110negative regulation of meiosis (GO:0045835)2.78401382
111regulation of prostaglandin secretion (GO:0032306)2.78384538
112superoxide anion generation (GO:0042554)2.77925826
113regulation of circadian sleep/wake cycle (GO:0042749)2.77842252
114regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.77842252
115positive regulation of coagulation (GO:0050820)2.77419725
116positive regulation of vascular permeability (GO:0043117)2.75112867
117positive regulation of T cell cytokine production (GO:0002726)2.74387234
118modulation by virus of host process (GO:0019054)2.74110063
119plasma lipoprotein particle remodeling (GO:0034369)2.73130058
120protein-lipid complex remodeling (GO:0034368)2.73130058
121macromolecular complex remodeling (GO:0034367)2.73130058
122histone H3-K4 trimethylation (GO:0080182)2.73086664
123mesenchymal cell differentiation (GO:0048762)2.73024680
124phenylpropanoid metabolic process (GO:0009698)2.71892013
125histone H3-K36 demethylation (GO:0070544)2.71745522
126neurotransmitter transport (GO:0006836)2.71150266
127interferon-gamma production (GO:0032609)2.70616723
128regulation of icosanoid secretion (GO:0032303)2.68556179
129succinate metabolic process (GO:0006105)2.66677947
130negative regulation of blood coagulation (GO:0030195)2.65182368
131negative regulation of hemostasis (GO:1900047)2.65182368
132glycoside metabolic process (GO:0016137)2.65028644
133cellular response to ethanol (GO:0071361)2.64932451
134regulation of glutamate receptor signaling pathway (GO:1900449)2.64673448
135monocyte chemotaxis (GO:0002548)2.64458437
136positive regulation of interleukin-1 beta secretion (GO:0050718)2.63334383
137urea cycle (GO:0000050)2.62991448
138regulation of uterine smooth muscle contraction (GO:0070472)2.62933968
139regulation of somitogenesis (GO:0014807)2.61151352
140macrophage activation (GO:0042116)2.60795965
141positive regulation of neurotransmitter secretion (GO:0001956)2.60580061
142S-adenosylmethionine metabolic process (GO:0046500)2.59364619
143cell proliferation involved in metanephros development (GO:0072203)2.58712895
144glutamate receptor signaling pathway (GO:0007215)2.57145132
145regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.56352001
146neuron-neuron synaptic transmission (GO:0007270)2.56059045
147positive regulation of interleukin-1 secretion (GO:0050716)2.55796141
148very-low-density lipoprotein particle assembly (GO:0034379)2.55741564
149negative regulation of interleukin-12 production (GO:0032695)2.55455009
150regulation of neurotransmitter levels (GO:0001505)2.54967073
151regulation of germinal center formation (GO:0002634)2.54895450
152ganglion development (GO:0061548)2.54781544
153steroid catabolic process (GO:0006706)2.53290293
154positive regulation of protein sumoylation (GO:0033235)2.53188296
155positive regulation of synapse maturation (GO:0090129)2.52589806
156cell differentiation involved in metanephros development (GO:0072202)2.52410500
157proline transport (GO:0015824)2.52400445
158estrogen biosynthetic process (GO:0006703)2.51740187
159negative regulation of wound healing (GO:0061045)2.51521254
160regulation of long-term neuronal synaptic plasticity (GO:0048169)2.51342093
161positive regulation of fatty acid transport (GO:2000193)2.49045893
162bile acid metabolic process (GO:0008206)2.48795987
163sodium ion export (GO:0071436)2.48502542
164cellular extravasation (GO:0045123)2.45874489
165cellular response to zinc ion (GO:0071294)2.45093801
166regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.44662893
167regulation of DNA endoreduplication (GO:0032875)2.44104717
168regulation of keratinocyte proliferation (GO:0010837)2.43056959
169B cell homeostasis (GO:0001782)2.42752543
170regulation of humoral immune response (GO:0002920)2.42689301
171cell proliferation involved in kidney development (GO:0072111)2.41544578
172positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.40733605
173bone remodeling (GO:0046849)2.40671085
174regulation of B cell receptor signaling pathway (GO:0050855)2.40155056
175negative regulation of coagulation (GO:0050819)2.40145190
176positive regulation by symbiont of host defense response (GO:0052509)2.39783676
177modulation by symbiont of host defense response (GO:0052031)2.39783676
178modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39783676
179modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39783676
180positive regulation by organism of defense response of other organism involved in symbiotic interact2.39783676
181modulation by symbiont of host immune response (GO:0052553)2.39783676
182extracellular regulation of signal transduction (GO:1900115)2.39032561
183extracellular negative regulation of signal transduction (GO:1900116)2.39032561
184negative regulation of response to nutrient levels (GO:0032108)2.38167607
185negative regulation of response to extracellular stimulus (GO:0032105)2.38167607
186negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37828289
187fat-soluble vitamin catabolic process (GO:0042363)2.36425576
188vitamin catabolic process (GO:0009111)2.36425576
189maintenance of gastrointestinal epithelium (GO:0030277)2.36363806
190response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.34203871
191response to host immune response (GO:0052572)2.34203871
192mesonephros development (GO:0001823)2.33729348
193cerebral cortex radially oriented cell migration (GO:0021799)2.32620446
194daunorubicin metabolic process (GO:0044597)12.7524545
195polyketide metabolic process (GO:0030638)12.7524545
196doxorubicin metabolic process (GO:0044598)12.7524545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.93838532
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.67182980
3EZH2_22144423_ChIP-Seq_EOC_Human3.27012906
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.25867289
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.17677887
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.86847606
7REST_18959480_ChIP-ChIP_MESCs_Mouse2.52947072
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52788414
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.52275980
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48483455
11REST_21632747_ChIP-Seq_MESCs_Mouse2.44401357
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.30370252
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.26530919
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.24125173
15IGF1R_20145208_ChIP-Seq_DFB_Human2.14185977
16NFE2_27457419_Chip-Seq_LIVER_Mouse2.13177622
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.99093584
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97890089
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93071358
20P300_19829295_ChIP-Seq_ESCs_Human1.91208086
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89464162
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.89456660
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.89361282
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85521432
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.85349669
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85069169
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83817636
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83212406
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.82726944
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81888446
31E2F1_18555785_Chip-Seq_ESCs_Mouse1.80962633
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.79652003
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78562828
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78376007
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.77978534
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77073966
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74741159
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.73927160
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72405984
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72301634
41SUZ12_18555785_Chip-Seq_ESCs_Mouse1.71209881
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69950717
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.68482335
44P53_22387025_ChIP-Seq_ESCs_Mouse1.66313963
45TAF15_26573619_Chip-Seq_HEK293_Human1.65086261
46STAT3_18555785_Chip-Seq_ESCs_Mouse1.64862306
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64714941
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.60385750
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58690822
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.58481294
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54883503
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.54289250
53NMYC_18555785_Chip-Seq_ESCs_Mouse1.53016664
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52075000
55EWS_26573619_Chip-Seq_HEK293_Human1.51729096
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51654188
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51360232
58HTT_18923047_ChIP-ChIP_STHdh_Human1.49565960
59SMAD4_21799915_ChIP-Seq_A2780_Human1.48249380
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.46561422
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.45366920
62SOX2_18555785_Chip-Seq_ESCs_Mouse1.45336308
63EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.44764035
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44579964
65RNF2_27304074_Chip-Seq_NSC_Mouse1.44408914
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.44248859
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43626037
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43336653
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43336653
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42829815
71RUNX1_27457419_Chip-Seq_LIVER_Mouse1.42700616
72P300_18555785_Chip-Seq_ESCs_Mouse1.42392270
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41858316
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41781101
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41697646
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.39917302
77PU1_27457419_Chip-Seq_LIVER_Mouse1.39342234
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.39329871
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37640371
80ZFX_18555785_Chip-Seq_ESCs_Mouse1.37225271
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37139356
82ER_23166858_ChIP-Seq_MCF-7_Human1.37076189
83VDR_22108803_ChIP-Seq_LS180_Human1.36656631
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36301583
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36301583
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35406887
87ESRRB_18555785_Chip-Seq_ESCs_Mouse1.35371538
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33289195
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32572361
90STAT3_23295773_ChIP-Seq_U87_Human1.31855579
91RXR_22108803_ChIP-Seq_LS180_Human1.31028731
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30896766
93FUS_26573619_Chip-Seq_HEK293_Human1.30818362
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30472767
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28283059
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.28247448
97CTCF_18555785_Chip-Seq_ESCs_Mouse1.27564121
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.26771632
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25676020
100GATA1_22025678_ChIP-Seq_K562_Human1.25479101
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24800344
102TCF4_23295773_ChIP-Seq_U87_Human1.24471365
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24459457
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23501028
105DROSHA_22980978_ChIP-Seq_HELA_Human1.23287442
106AR_25329375_ChIP-Seq_VCAP_Human1.20222591
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19181335
108POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17122291
109LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16848668
110RUNX2_22187159_ChIP-Seq_PCA_Human1.16783606
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16020000
112SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15220917
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14975127
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.14713772
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14166996
116HNF4A_19822575_ChIP-Seq_HepG2_Human1.12548277
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.11941976
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11605552
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11118694
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10996433
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10237360
122TP53_18474530_ChIP-ChIP_U2OS_Human1.09049059
123KDM2B_26808549_Chip-Seq_REH_Human1.06799344
124CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06564691
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06461741
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06382027
127DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04441609
128CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04190913
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04070595
130CBP_20019798_ChIP-Seq_JUKART_Human1.04070595
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02703270
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.02612289
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02594100
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00463424
135NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00463424
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.99730602
137REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97679869
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97390138
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97293778
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95968461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.21603072
2MP0000566_synostosis4.67677766
3MP0004859_abnormal_synaptic_plasticity4.18280312
4MP0005645_abnormal_hypothalamus_physiol3.83234810
5MP0005257_abnormal_intraocular_pressure3.64341452
6MP0002277_abnormal_respiratory_mucosa3.63173414
7MP0008004_abnormal_stomach_pH3.53401265
8MP0006292_abnormal_olfactory_placode3.50954160
9MP0003878_abnormal_ear_physiology3.50358929
10MP0005377_hearing/vestibular/ear_phenot3.50358929
11MP0003195_calcinosis3.32758790
12MP0005365_abnormal_bile_salt3.12145687
13MP0000569_abnormal_digit_pigmentation3.07106871
14MP0009697_abnormal_copulation3.03470764
15MP0001986_abnormal_taste_sensitivity2.99866789
16MP0003880_abnormal_central_pattern2.96954001
17MP0002138_abnormal_hepatobiliary_system2.86052043
18MP0001188_hyperpigmentation2.46268861
19MP0003635_abnormal_synaptic_transmissio2.45826921
20MP0005646_abnormal_pituitary_gland2.44936233
21MP0002163_abnormal_gland_morphology2.33048799
22MP0003252_abnormal_bile_duct2.32154949
23MP0002064_seizures2.28923417
24MP0003941_abnormal_skin_development2.23703948
25MP0009745_abnormal_behavioral_response2.23236459
26MP0002938_white_spotting2.19253506
27MP0005171_absent_coat_pigmentation2.11727525
28MP0008875_abnormal_xenobiotic_pharmacok2.09454715
29MP0004270_analgesia2.09025916
30MP0000678_abnormal_parathyroid_gland2.08128716
31MP0002063_abnormal_learning/memory/cond2.07381530
32MP0002396_abnormal_hematopoietic_system2.06661866
33MP0001348_abnormal_lacrimal_gland2.00583766
34MP0000604_amyloidosis2.00123789
35MP0002272_abnormal_nervous_system1.92799136
36MP0001346_abnormal_lacrimal_gland1.84122473
37MP0002638_abnormal_pupillary_reflex1.83769695
38MP0005085_abnormal_gallbladder_physiolo1.79246723
39MP0005379_endocrine/exocrine_gland_phen1.78350875
40MP0003329_amyloid_beta_deposits1.78222348
41MP0010386_abnormal_urinary_bladder1.77445436
42MP0004742_abnormal_vestibular_system1.64622223
43MP0009840_abnormal_foam_cell1.64565696
44MP0003633_abnormal_nervous_system1.63542565
45MP0003787_abnormal_imprinting1.58022150
46MP0000015_abnormal_ear_pigmentation1.57719804
47MP0003879_abnormal_hair_cell1.57275528
48MP0001666_abnormal_nutrient_absorption1.56159734
49MP0002102_abnormal_ear_morphology1.56103252
50MP0003303_peritoneal_inflammation1.54371475
51MP0006276_abnormal_autonomic_nervous1.54027641
52MP0005423_abnormal_somatic_nervous1.51878109
53MP0001486_abnormal_startle_reflex1.49285803
54MP0005310_abnormal_salivary_gland1.47886551
55MP0005409_darkened_coat_color1.46516960
56MP0003868_abnormal_feces_composition1.45025256
57MP0003656_abnormal_erythrocyte_physiolo1.44920100
58MP0003283_abnormal_digestive_organ1.40834380
59MP0010329_abnormal_lipoprotein_level1.39025798
60MP0002735_abnormal_chemical_nociception1.38324188
61MP0000013_abnormal_adipose_tissue1.30053512
62MP0003690_abnormal_glial_cell1.29470432
63MP0001542_abnormal_bone_strength1.28578365
64MP0005174_abnormal_tail_pigmentation1.28258377
65MP0000920_abnormal_myelination1.26932016
66MP0002998_abnormal_bone_remodeling1.26255110
67MP0002132_abnormal_respiratory_system1.25198234
68MP0000681_abnormal_thyroid_gland1.23350734
69MP0008569_lethality_at_weaning1.22824991
70MP0003075_altered_response_to1.22669054
71MP0003045_fibrosis1.20985129
72MP0003631_nervous_system_phenotype1.18867229
73MP0005671_abnormal_response_to1.18403693
74MP0008874_decreased_physiological_sensi1.15807605
75MP0004811_abnormal_neuron_physiology1.15521101
76MP0005386_behavior/neurological_phenoty1.15096640
77MP0004924_abnormal_behavior1.15096640
78MP0002734_abnormal_mechanical_nocicepti1.13877475
79MP0010368_abnormal_lymphatic_system1.13682870
80MP0004142_abnormal_muscle_tone1.09251449
81MP0001835_abnormal_antigen_presentation1.06764767
82MP0002067_abnormal_sensory_capabilities1.04021624
83MP0003122_maternal_imprinting1.03283929
84MP0002095_abnormal_skin_pigmentation1.03178858
85MP0001485_abnormal_pinna_reflex1.02279988
86MP0003136_yellow_coat_color1.02138626
87MP0002148_abnormal_hypersensitivity_rea1.01599762
88MP0005503_abnormal_tendon_morphology1.01174409
89MP0005387_immune_system_phenotype1.01041299
90MP0001790_abnormal_immune_system1.01041299
91MP0001501_abnormal_sleep_pattern1.00139386
92MP0002876_abnormal_thyroid_physiology1.00106904
93MP0005332_abnormal_amino_acid1.00010184
94MP0000372_irregular_coat_pigmentation0.99929520
95MP0005535_abnormal_body_temperature0.99136818
96MP0000049_abnormal_middle_ear0.97680478
97MP0000609_abnormal_liver_physiology0.97212009
98MP0002557_abnormal_social/conspecific_i0.95396996
99MP0002249_abnormal_larynx_morphology0.94879198
100MP0002733_abnormal_thermal_nociception0.93891013
101MP0002075_abnormal_coat/hair_pigmentati0.93561960
102MP0001970_abnormal_pain_threshold0.93049362
103MP0003300_gastrointestinal_ulcer0.92581628
104MP0005075_abnormal_melanosome_morpholog0.92275020
105MP0005167_abnormal_blood-brain_barrier0.91949788
106MP0001186_pigmentation_phenotype0.89217076
107MP0002066_abnormal_motor_capabilities/c0.88239441
108MP0002118_abnormal_lipid_homeostasis0.88188164
109MP0005084_abnormal_gallbladder_morpholo0.87874215
110MP0002896_abnormal_bone_mineralization0.87158759
111MP0001915_intracranial_hemorrhage0.84399262
112MP0002177_abnormal_outer_ear0.83185252
113MP0009250_abnormal_appendicular_skeleto0.82893198
114MP0001963_abnormal_hearing_physiology0.81443892
115MP0001293_anophthalmia0.80617839
116MP0002109_abnormal_limb_morphology0.80418913
117MP0002419_abnormal_innate_immunity0.80261217
118MP0001764_abnormal_homeostasis0.80251957
119MP0002837_dystrophic_cardiac_calcinosis0.79202632
120MP0000778_abnormal_nervous_system0.78700199
121MP0001984_abnormal_olfaction0.78580609
122MP0001529_abnormal_vocalization0.77701598
123MP0006035_abnormal_mitochondrial_morpho0.77031973
124MP0008438_abnormal_cutaneous_collagen0.76884411
125MP0004381_abnormal_hair_follicle0.76656460
126MP0003634_abnormal_glial_cell0.75914246
127MP0002909_abnormal_adrenal_gland0.74567751
128MP0001324_abnormal_eye_pigmentation0.74006000
129MP0002113_abnormal_skeleton_development0.73868739
130MP0002572_abnormal_emotion/affect_behav0.73407053
131MP0003436_decreased_susceptibility_to0.73356421
132MP0003121_genomic_imprinting0.72780356
133MP0002229_neurodegeneration0.72205597
134MP0001299_abnormal_eye_distance/0.71819834
135MP0001440_abnormal_grooming_behavior0.70792774
136MP0002693_abnormal_pancreas_physiology0.69923161
137MP0006036_abnormal_mitochondrial_physio0.69241050
138MP0001800_abnormal_humoral_immune0.68668095
139MP0008469_abnormal_protein_level0.68534033
140MP0009764_decreased_sensitivity_to0.68058939
141MP0003806_abnormal_nucleotide_metabolis0.67293403
142MP0002928_abnormal_bile_duct0.67127316
143MP0005451_abnormal_body_composition0.67025046
144MP0000631_abnormal_neuroendocrine_gland0.66942483
145MP0003795_abnormal_bone_structure0.66842282
146MP0000026_abnormal_inner_ear0.66757356
147MP0002736_abnormal_nociception_after0.66733502
148MP0001533_abnormal_skeleton_physiology0.66495871
149MP0003959_abnormal_lean_body0.65993703
150MP0002452_abnormal_antigen_presenting0.65871665
151MP0001502_abnormal_circadian_rhythm0.65671531
152MP0000613_abnormal_salivary_gland0.63866901
153MP0000470_abnormal_stomach_morphology0.63852720
154MP0001968_abnormal_touch/_nociception0.63516577
155MP0002723_abnormal_immune_serum0.63207915
156MP0003172_abnormal_lysosome_physiology0.60847692
157MP0002233_abnormal_nose_morphology0.60762597
158MP0005390_skeleton_phenotype0.60470026
159MP0002116_abnormal_craniofacial_bone0.60317859
160MP0002098_abnormal_vibrissa_morphology0.59651708
161MP0009046_muscle_twitch0.59188814
162MP0004782_abnormal_surfactant_physiolog0.58819747
163MP0001119_abnormal_female_reproductive0.58279365
164MP0002184_abnormal_innervation0.57585058
165MP0004134_abnormal_chest_morphology0.57395913
166MP0001819_abnormal_immune_cell0.56582914
167MP0005000_abnormal_immune_tolerance0.56033680
168MP0005367_renal/urinary_system_phenotyp0.55671832
169MP0000516_abnormal_urinary_system0.55671832
170MP0003385_abnormal_body_wall0.55571155

Predicted human phenotypes

RankGene SetZ-score
1Papilledema (HP:0001085)6.14440985
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.72865419
3Deep venous thrombosis (HP:0002625)5.43323114
4Unilateral renal agenesis (HP:0000122)5.05373494
5Parakeratosis (HP:0001036)4.95692762
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.69469915
7Cheilitis (HP:0100825)4.28368950
8Prolonged partial thromboplastin time (HP:0003645)4.20339877
9Absent eyebrow (HP:0002223)4.15429236
10Prostate neoplasm (HP:0100787)4.09285528
11Chromosomal breakage induced by crosslinking agents (HP:0003221)4.04673936
12Alopecia of scalp (HP:0002293)3.92718254
13Hypophosphatemic rickets (HP:0004912)3.82745208
14Follicular hyperkeratosis (HP:0007502)3.80985191
15Complement deficiency (HP:0004431)3.72474693
16Hypobetalipoproteinemia (HP:0003563)3.71914268
17Abnormality of dental color (HP:0011073)3.69733332
18Chromsome breakage (HP:0040012)3.62441199
19Epileptic encephalopathy (HP:0200134)3.55445902
20Metaphyseal dysplasia (HP:0100255)3.48856288
21Atonic seizures (HP:0010819)3.34891133
22Patchy hypopigmentation of hair (HP:0011365)3.33030501
23Absent/shortened dynein arms (HP:0200106)3.30803140
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.30803140
25Absence seizures (HP:0002121)3.19122099
26White forelock (HP:0002211)3.11072577
27Focal seizures (HP:0007359)3.08508334
28Hyperphosphatemia (HP:0002905)3.08357107
29Absent eyelashes (HP:0000561)3.05861552
30Osteomalacia (HP:0002749)3.05198334
31Bilateral sensorineural hearing impairment (HP:0008619)3.05159070
32Congenital sensorineural hearing impairment (HP:0008527)3.02308688
33Abnormality of incisor morphology (HP:0011063)3.00340437
34Myokymia (HP:0002411)2.98265898
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.96902318
36Scanning speech (HP:0002168)2.96343307
37Supranuclear gaze palsy (HP:0000605)2.95128156
38Febrile seizures (HP:0002373)2.93668604
39Recurrent corneal erosions (HP:0000495)2.82137276
40Chronic hepatic failure (HP:0100626)2.78390855
41Torticollis (HP:0000473)2.74678805
42Ectropion (HP:0000656)2.65570078
43Focal dystonia (HP:0004373)2.64892451
44Hyperlipoproteinemia (HP:0010980)2.64739407
45Insidious onset (HP:0003587)2.63491670
46Termporal pattern (HP:0011008)2.63491670
47Craniofacial dystonia (HP:0012179)2.63352214
48Septo-optic dysplasia (HP:0100842)2.63234586
49Aplasia cutis congenita (HP:0001057)2.62158084
50Spontaneous abortion (HP:0005268)2.60609539
51Abnormality of complement system (HP:0005339)2.60503504
52Alveolar cell carcinoma (HP:0006519)2.59663148
53Joint hemorrhage (HP:0005261)2.57881805
54Action tremor (HP:0002345)2.57261302
55Dialeptic seizures (HP:0011146)2.57210804
56Ectopic kidney (HP:0000086)2.55974475
57Rickets (HP:0002748)2.51511235
58Abnormality of the renal collecting system (HP:0004742)2.51024426
59Abnormality of the corticospinal tract (HP:0002492)2.44975630
60Metaphyseal irregularity (HP:0003025)2.44242570
61Generalized tonic-clonic seizures (HP:0002069)2.44036779
62Duplicated collecting system (HP:0000081)2.41616951
63Mutism (HP:0002300)2.41446789
64Recurrent pneumonia (HP:0006532)2.39895260
65Neoplasm of the tracheobronchial system (HP:0100552)2.37089633
66Renal dysplasia (HP:0000110)2.36262689
67Impaired vibration sensation in the lower limbs (HP:0002166)2.33282476
68Abnormal ciliary motility (HP:0012262)2.32974097
69Abnormality of the common coagulation pathway (HP:0010990)2.30961515
70Abnormality of the intrinsic pathway (HP:0010989)2.30919507
71Tetany (HP:0001281)2.27731321
72Abnormality of the prostate (HP:0008775)2.27544607
73Increased density of long bones (HP:0006392)2.27350719
74Steatorrhea (HP:0002570)2.26755517
75Spastic gait (HP:0002064)2.25927355
76Neurofibrillary tangles (HP:0002185)2.24898246
77Status epilepticus (HP:0002133)2.23841824
78Chronic diarrhea (HP:0002028)2.23572171
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22263930
80Degeneration of the lateral corticospinal tracts (HP:0002314)2.22263930
81Large eyes (HP:0001090)2.21982995
82Retrobulbar optic neuritis (HP:0100654)2.21071414
83Optic neuritis (HP:0100653)2.21071414
84Tetraparesis (HP:0002273)2.18380124
85Neoplasm of the lung (HP:0100526)2.16855173
86Epidermoid cyst (HP:0200040)2.15827880
87Recurrent cutaneous fungal infections (HP:0011370)2.14639889
88Chronic mucocutaneous candidiasis (HP:0002728)2.14639889
89Agammaglobulinemia (HP:0004432)2.13570465
90Decreased central vision (HP:0007663)2.12823996
91Chronic otitis media (HP:0000389)2.12667905
92Abnormality of the parietal bone (HP:0002696)2.12391052
93Arthropathy (HP:0003040)2.12262025
94Mild short stature (HP:0003502)2.11902912
95Abnormality of binocular vision (HP:0011514)2.11671714
96Diplopia (HP:0000651)2.11671714
97Small epiphyses (HP:0010585)2.10657621
98Microvesicular hepatic steatosis (HP:0001414)2.10271386
99Abnormality of the vertebral endplates (HP:0005106)2.08395874
100Midline defect of the nose (HP:0004122)2.08343059
101Keratitis (HP:0000491)2.07511587
102True hermaphroditism (HP:0010459)2.07468960
103Fat malabsorption (HP:0002630)2.07339312
104Postural tremor (HP:0002174)2.05956516
105Broad ribs (HP:0000885)2.05857437
106Urinary urgency (HP:0000012)2.04999468
107Epileptiform EEG discharges (HP:0011182)2.02989197
108Pancreatic fibrosis (HP:0100732)2.02011217
109Xanthomatosis (HP:0000991)2.01022790
110Hyperactive renin-angiotensin system (HP:0000841)2.00956568
111Abnormality of the intervertebral disk (HP:0005108)2.00801571
112Conical tooth (HP:0000698)2.00706889
113Overgrowth (HP:0001548)2.00031770
114Urinary bladder sphincter dysfunction (HP:0002839)1.99377241
115Abnormality of proline metabolism (HP:0010907)1.98386896
116Hydroxyprolinuria (HP:0003080)1.98386896
117Impaired vibratory sensation (HP:0002495)1.98061309
118Clubbing of toes (HP:0100760)1.97936092
119Hip dysplasia (HP:0001385)1.97117454
120Abnormal respiratory motile cilium morphology (HP:0005938)1.96368378
121Abnormal respiratory epithelium morphology (HP:0012253)1.96368378
122Abnormality of calcium-phosphate metabolism (HP:0100530)1.95307301
123Conjugated hyperbilirubinemia (HP:0002908)1.95207734
124Bone pain (HP:0002653)1.95014600
125Enlarged epiphyses (HP:0010580)1.93638944
126Systemic lupus erythematosus (HP:0002725)1.92903490
127Abnormality of the right ventricle (HP:0001707)1.92354933
128EEG with generalized epileptiform discharges (HP:0011198)1.92244022
129Hypothermia (HP:0002045)1.91641253
130Glomerulonephritis (HP:0000099)1.89830244
131Depression (HP:0000716)1.89653504
132Abnormality of the nasal septum (HP:0000419)1.89594323
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.85744601
134Lip pit (HP:0100267)1.85507121
135Amelogenesis imperfecta (HP:0000705)1.85481969
136Hypergonadotropic hypogonadism (HP:0000815)1.85414013
137Absent hair (HP:0002298)1.85379881
138Popliteal pterygium (HP:0009756)1.84569784
139Joint swelling (HP:0001386)1.84231867
140Oligodontia (HP:0000677)1.82794541
141Submucous cleft hard palate (HP:0000176)1.82016404
142Cutaneous finger syndactyly (HP:0010554)1.81847036
143Abnormality of DNA repair (HP:0003254)1.80195851
144Oligohydramnios (HP:0001562)1.79893554
145Paraplegia (HP:0010550)1.77939864
146Small hand (HP:0200055)1.76696618
147Neoplasm of the respiratory system (HP:0100606)1.75236027
148Autoamputation (HP:0001218)1.74945101
149Bile duct proliferation (HP:0001408)1.74599220
150Abnormal biliary tract physiology (HP:0012439)1.74599220
151Hypsarrhythmia (HP:0002521)1.74349511
152Renal cortical cysts (HP:0000803)1.74309133
153Abnormality of the preputium (HP:0100587)1.73089634
154Elevated alkaline phosphatase (HP:0003155)1.72237664
155Insomnia (HP:0100785)1.72224412
156Blepharitis (HP:0000498)1.72150409
157Erythroderma (HP:0001019)1.71610777
158Recurrent abscess formation (HP:0002722)1.71531309
159Abolished electroretinogram (ERG) (HP:0000550)1.71309851
160Orchitis (HP:0100796)1.71130713
161Spondylolisthesis (HP:0003302)1.70689346
162Hypolipoproteinemia (HP:0010981)1.70588747
163Generalized aminoaciduria (HP:0002909)1.69645872
164Anxiety (HP:0000739)1.69067927
165Morphological abnormality of the pyramidal tract (HP:0002062)1.67622097
166Truncal ataxia (HP:0002078)1.67429869
167Increased number of teeth (HP:0011069)1.67316560
168Hemiparesis (HP:0001269)1.67211464
169Impaired smooth pursuit (HP:0007772)1.66515300
170Orthostatic hypotension (HP:0001278)1.65798108
171Visual hallucinations (HP:0002367)1.65729575
172Recurrent lower respiratory tract infections (HP:0002783)1.65616568
173Abnormality of the incisor (HP:0000676)1.65566445
174Gingival bleeding (HP:0000225)1.65188886
175Craniofacial hyperostosis (HP:0004493)1.64881399
176Peripheral hypomyelination (HP:0007182)1.64611454
177Irregular vertebral endplates (HP:0003301)1.64194361
178Abnormal eating behavior (HP:0100738)1.64021633
179Abnormality of ocular smooth pursuit (HP:0000617)1.63574843
180Limb dystonia (HP:0002451)1.63469996
181Fair hair (HP:0002286)1.63274212
182Lower limb muscle weakness (HP:0007340)1.63106625
183Hypoplastic iliac wings (HP:0002866)1.62951642
184Pulmonary embolism (HP:0002204)1.62799392
185Convex nasal ridge (HP:0000444)1.61203035
186Hyperaldosteronism (HP:0000859)1.60629439
187Mitral stenosis (HP:0001718)1.60399226
188Focal motor seizures (HP:0011153)1.59716877
189Widely spaced teeth (HP:0000687)1.59002358
190Metabolic alkalosis (HP:0200114)1.58758005
191Renal agenesis (HP:0000104)1.58604751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK37.33709108
2SIK24.22267072
3SIK13.42616978
4EPHA43.15681723
5CDK83.03440617
6PAK62.93596593
7TXK2.77979763
8MARK12.73119972
9MAP3K92.67261080
10NEK92.58892997
11INSRR2.57436709
12DAPK22.53627202
13MARK32.51228196
14MAP3K42.49908295
15CAMKK22.11161025
16PINK12.09463991
17ZAK2.06874439
18TNIK2.02348879
19EIF2AK12.00495722
20NTRK21.97666141
21CASK1.94859276
22NTRK11.93987973
23LATS11.86371133
24MAP3K141.85973224
25KSR21.84038973
26MAP3K111.80809910
27ADRBK21.76754235
28CAMKK11.73668358
29SCYL21.62871244
30GRK71.61437853
31DAPK11.58441148
32EIF2AK21.52593814
33RAF11.50475439
34STK38L1.48546150
35TAOK11.36920453
36CDK31.35585506
37CDK121.34988237
38UHMK11.28433585
39ARAF1.27670935
40NUAK11.27472060
41MAPK131.26224719
42TNK21.26107583
43MAP2K71.25897889
44SGK21.25723378
45TGFBR21.25170608
46MAP2K41.23339586
47NTRK31.22759297
48PRPF4B1.20989244
49IRAK31.20438207
50IRAK41.19320544
51SRPK11.19319831
52TEC1.18806387
53EIF2AK31.16333351
54ALK1.16217424
55MINK11.16136247
56MAP3K51.13984985
57YES11.09643003
58PRKCG1.09294717
59MKNK21.06504664
60CDK51.05786887
61PIM21.05568564
62ERN11.02105826
63CAMK1D1.01322471
64MAP3K11.00112046
65BMPR1B0.99401580
66FGFR30.98902366
67PRKCH0.97332489
68MARK20.97229004
69RIPK40.93809371
70PDK10.93039245
71CSNK1G20.92178473
72MAP3K130.91735600
73RIPK10.90805314
74CAMK1G0.90477435
75BMPR20.89442743
76STK30.89328757
77PIK3CA0.82597176
78CSNK1A1L0.82172439
79AKT30.81590637
80JAK30.80985718
81EPHA20.80506747
82DDR20.79707393
83CAMK10.79398227
84LATS20.78763737
85MOS0.78217690
86IKBKB0.77752258
87KIT0.76852479
88CSNK1G30.75530613
89PIK3CG0.73182528
90WNK10.72413765
91PDGFRA0.69266108
92FGFR40.68938654
93CAMK40.68460004
94KSR10.68138162
95PBK0.67687226
96SGK30.67467446
97VRK10.67452318
98CAMK2A0.67255392
99CDK70.67157689
100FES0.63863532
101FRK0.63676988
102BRD40.63639336
103TAOK30.63375357
104MAP2K60.63348701
105CHUK0.63227088
106NLK0.62685303
107JAK10.61130493
108PDPK10.60235136
109ATR0.60173747
110NEK60.59125168
111IRAK20.59115253
112MAP3K60.57984298
113TBK10.57753829
114CHEK20.57090124
115IRAK10.56363748
116BLK0.56354909
117MAPK100.56073319
118MAPK120.56056555
119LYN0.55642444
120SGK2230.55483584
121SGK4940.55483584
122PRKAA20.55028018
123PLK40.54667272
124MAP3K120.54305771
125ITK0.54020764
126CDK140.53724203
127MAPK70.52785127
128MAPK110.52652370
129PLK20.52423779
130RPS6KB10.49133393
131PAK30.48908799
132IKBKE0.48532497
133CDK150.48338643
134CAMK2B0.47118241
135TYRO30.47103412
136JAK20.47078894
137CSNK1G10.46681950
138MKNK10.46541227
139ABL20.46035015
140EPHA30.45715399
141RPS6KA30.45405799
142CDK11A0.44714211
143MATK0.44572290
144PRKACG0.44395506
145STK160.43986155
146SGK10.42560227
147PRKCE0.42559500
148CCNB10.41804999
149TAOK20.41232930
150CDK180.41202403
151PRKG10.40883102
152PRKCB0.39588263
153MUSK0.39225467
154CSNK1E0.39124380
155MAPK150.38355108
156STK380.38017344
157BCR0.37849952
158TIE10.37396157
159SYK0.36942089
160HCK0.35900139
161GRK10.33107376
162AKT10.29832371
163RPS6KA50.29166770
164ATM0.28738485
165PRKCQ0.27334567
166CSNK1D0.26289199
167BTK0.25798046
168PKN10.25482359
169PRKAA10.25029060

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.95329626
2Complement and coagulation cascades_Homo sapiens_hsa046103.86604093
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.26705498
4Synaptic vesicle cycle_Homo sapiens_hsa047212.66982726
5Caffeine metabolism_Homo sapiens_hsa002322.61261661
6Butanoate metabolism_Homo sapiens_hsa006502.47720208
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.18139168
8Nicotine addiction_Homo sapiens_hsa050332.12373925
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04423267
10Arginine biosynthesis_Homo sapiens_hsa002202.02235420
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94317415
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.94211797
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88186715
14GABAergic synapse_Homo sapiens_hsa047271.86794344
15Prion diseases_Homo sapiens_hsa050201.82029670
16Hematopoietic cell lineage_Homo sapiens_hsa046401.76002754
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.75006201
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73245943
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71541131
20Vitamin B6 metabolism_Homo sapiens_hsa007501.67603942
21Primary immunodeficiency_Homo sapiens_hsa053401.67523747
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.65382609
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64096598
24Taste transduction_Homo sapiens_hsa047421.62373283
25Measles_Homo sapiens_hsa051621.59302400
26Long-term potentiation_Homo sapiens_hsa047201.58416151
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54700737
28Fanconi anemia pathway_Homo sapiens_hsa034601.53435273
29Phenylalanine metabolism_Homo sapiens_hsa003601.50794853
30Basal transcription factors_Homo sapiens_hsa030221.49765930
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49354100
32Amphetamine addiction_Homo sapiens_hsa050311.49198510
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48759975
34Mineral absorption_Homo sapiens_hsa049781.46702070
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42950414
36Bile secretion_Homo sapiens_hsa049761.41627075
37Rheumatoid arthritis_Homo sapiens_hsa053231.41318934
38Homologous recombination_Homo sapiens_hsa034401.40978078
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38436574
40Osteoclast differentiation_Homo sapiens_hsa043801.37513246
41Autoimmune thyroid disease_Homo sapiens_hsa053201.35685498
42Retinol metabolism_Homo sapiens_hsa008301.34294281
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33243673
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30279966
45Peroxisome_Homo sapiens_hsa041461.27183755
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27147443
47Melanoma_Homo sapiens_hsa052181.24457137
48Morphine addiction_Homo sapiens_hsa050321.23686985
49Leishmaniasis_Homo sapiens_hsa051401.22669593
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22201801
51Graft-versus-host disease_Homo sapiens_hsa053321.21716220
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.21039535
53Type II diabetes mellitus_Homo sapiens_hsa049301.20628641
54Fatty acid degradation_Homo sapiens_hsa000711.19389817
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19041018
56Chemical carcinogenesis_Homo sapiens_hsa052041.17833986
57Serotonergic synapse_Homo sapiens_hsa047261.14690159
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13418846
59TNF signaling pathway_Homo sapiens_hsa046681.12847373
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12677724
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09909466
62Calcium signaling pathway_Homo sapiens_hsa040201.09036177
63Sphingolipid metabolism_Homo sapiens_hsa006001.07805194
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07705466
65NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07660716
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07470421
67African trypanosomiasis_Homo sapiens_hsa051431.06729358
68Glycosaminoglycan degradation_Homo sapiens_hsa005311.06282825
69Herpes simplex infection_Homo sapiens_hsa051681.06145790
70Allograft rejection_Homo sapiens_hsa053301.05783560
71One carbon pool by folate_Homo sapiens_hsa006701.04534686
72Jak-STAT signaling pathway_Homo sapiens_hsa046301.03502178
73Drug metabolism - other enzymes_Homo sapiens_hsa009831.03407789
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98993733
75Tryptophan metabolism_Homo sapiens_hsa003800.97986594
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97303010
77Influenza A_Homo sapiens_hsa051640.96344707
78Phototransduction_Homo sapiens_hsa047440.96269153
79Olfactory transduction_Homo sapiens_hsa047400.95462938
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95343540
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92641269
82Ovarian steroidogenesis_Homo sapiens_hsa049130.92100470
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91740801
84Dopaminergic synapse_Homo sapiens_hsa047280.90454555
85T cell receptor signaling pathway_Homo sapiens_hsa046600.89001466
86Prolactin signaling pathway_Homo sapiens_hsa049170.88632687
87Tuberculosis_Homo sapiens_hsa051520.87598853
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87573076
89Collecting duct acid secretion_Homo sapiens_hsa049660.87100356
90Long-term depression_Homo sapiens_hsa047300.86673797
91Fatty acid metabolism_Homo sapiens_hsa012120.84122107
92Staphylococcus aureus infection_Homo sapiens_hsa051500.82300608
93Cholinergic synapse_Homo sapiens_hsa047250.81837244
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80881946
95Axon guidance_Homo sapiens_hsa043600.80600094
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79875543
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78983700
98Insulin secretion_Homo sapiens_hsa049110.78175869
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76815535
100Circadian entrainment_Homo sapiens_hsa047130.73310451
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.73245786
102Vibrio cholerae infection_Homo sapiens_hsa051100.73178195
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71843356
104Ras signaling pathway_Homo sapiens_hsa040140.71428119
105Chemokine signaling pathway_Homo sapiens_hsa040620.71222647
106Pancreatic secretion_Homo sapiens_hsa049720.70814930
107Glutamatergic synapse_Homo sapiens_hsa047240.69767157
108Hepatitis B_Homo sapiens_hsa051610.69567103
109Wnt signaling pathway_Homo sapiens_hsa043100.68671334
110cAMP signaling pathway_Homo sapiens_hsa040240.67960424
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67935154
112Pancreatic cancer_Homo sapiens_hsa052120.66868707
113Phagosome_Homo sapiens_hsa041450.66773299
114Notch signaling pathway_Homo sapiens_hsa043300.65444120
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.64147911
116Malaria_Homo sapiens_hsa051440.64050389
117Other glycan degradation_Homo sapiens_hsa005110.62778958
118Circadian rhythm_Homo sapiens_hsa047100.62442833
119Pertussis_Homo sapiens_hsa051330.61781033
120Propanoate metabolism_Homo sapiens_hsa006400.60173469
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60040274
122Prostate cancer_Homo sapiens_hsa052150.59560122
123Steroid biosynthesis_Homo sapiens_hsa001000.59553606
124Renin secretion_Homo sapiens_hsa049240.57748861
125beta-Alanine metabolism_Homo sapiens_hsa004100.57329964
126Type I diabetes mellitus_Homo sapiens_hsa049400.56734512
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56116898
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56024772
129Toxoplasmosis_Homo sapiens_hsa051450.55100079
130ErbB signaling pathway_Homo sapiens_hsa040120.52679726
131Protein export_Homo sapiens_hsa030600.52495313
132Asthma_Homo sapiens_hsa053100.52259238
133HTLV-I infection_Homo sapiens_hsa051660.51771647
134MAPK signaling pathway_Homo sapiens_hsa040100.51684007
135Tyrosine metabolism_Homo sapiens_hsa003500.51683957
136Cocaine addiction_Homo sapiens_hsa050300.49990989
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49508360
138B cell receptor signaling pathway_Homo sapiens_hsa046620.49319974
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48729594
140Rap1 signaling pathway_Homo sapiens_hsa040150.48686808
141Oxytocin signaling pathway_Homo sapiens_hsa049210.48420951
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48265230
143Inositol phosphate metabolism_Homo sapiens_hsa005620.48090433
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47723955
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47401532
146Histidine metabolism_Homo sapiens_hsa003400.46576690
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46271639
148Thyroid hormone synthesis_Homo sapiens_hsa049180.45777772
149Choline metabolism in cancer_Homo sapiens_hsa052310.45358305
150Biosynthesis of amino acids_Homo sapiens_hsa012300.44964579
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44916700
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44867596
153Hepatitis C_Homo sapiens_hsa051600.44721291
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44648876
155FoxO signaling pathway_Homo sapiens_hsa040680.43641800
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43554124
157PPAR signaling pathway_Homo sapiens_hsa033200.42883000
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42540991
159VEGF signaling pathway_Homo sapiens_hsa043700.42440357
160Starch and sucrose metabolism_Homo sapiens_hsa005000.39842635
161Glioma_Homo sapiens_hsa052140.39411101
162Carbon metabolism_Homo sapiens_hsa012000.38418002
163Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36595810
164Arginine and proline metabolism_Homo sapiens_hsa003300.33937968
165Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33292494
166mTOR signaling pathway_Homo sapiens_hsa041500.30391005
167Sphingolipid signaling pathway_Homo sapiens_hsa040710.30116644
168ABC transporters_Homo sapiens_hsa020100.30017795
169GnRH signaling pathway_Homo sapiens_hsa049120.29097398
170Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26973290

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